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Aigar Ottas

https://www.etis.ee/CV/Aigar_Ottas/est
4.07.1985
737 4414
+372 737 4414
aigar.ottas@ut.ee
Lõpetanud molekulaar- ja rakubioloogia magistriõppe 2012. aastal, lõputöö teema käsitles rakku sisenevaid peptiide. Doktorantuuris keskendunud nahahaiguste metaboloomikale.

Teenistuskäik

Töökohad ja ametid
01.01.2020–31.12.2022   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, üldise biokeemia teadur (1,00)
01.01.2020–31.12.2022   
Istituto Italiano di Tecnologia, Teadur (1,00)
01.03.2018–...   
SA Tartu Ülikooli Kliinikum, Biopankade ja andmekogude kvaliteedijuht (0,50)
01.02.2018–31.08.2018   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, bio- ja siirdemeditsiini nooremteadur (0,50)
01.01.2018–31.08.2018   
Tartu Ülikool, Arstiteaduskond, Nooremteadur (0,50)
01.01.2017–31.12.2019   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, mass-spektromeetria labori spetsialist (0,50)
01.01.2016–31.12.2016   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, mass-spektromeetria labori spetsialist (0,50)
01.04.2015–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, mass-spektromeetria labori spetsialist (0,90)
21.05.2013–31.03.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, mass-spektromeetria labori spetsialist (1,00)
01.06.2012–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biokeemia instituut, Meditsiinilise biokeemia õppetool, Spetsialist (0,50)
01.06.2012–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Biokeemia instituut, mass-spektromeetria labori spetsialist (1,00)
01.06.2012–31.12.2019   
Tartu Ülikool, Meditsiiniteaduste valdkond, Tehniline töötaja (1,00)
2007–2007   
Tartu Ülikool, Tartu Ülikooli loodusmuuseum ja botaanikaaed, Tartu Ülikooli Muuseumid, giid (1,00)
 
 
Haridustee
2012–18.06.2019   
Tartu Ülikool, Meditsiiniteaduste valdkond, doktoriõpe (arstiteadus)
2010–2012   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, magistriõpe, eriala: molekulaar- ja rakubioloogia
2007–2010   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, bakalaureuseõpe, eriala: bioloogia
2004–2007   
Tartu Ülikool, Arstiteaduskond, arstiõpe (lõpetamata)
2001–2007   
Tartu Hugo Treffneri Gümnaasium
1992–2001   
Tartu Kommertsgümnaasium
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2014−2016   
Tartu Ülikooli Bio- ja siirdemeditsiini instituudi nõukogu liige

Kvalifikatsioon

Teaduskraadid
Aigar Ottas, doktorikraad, 2019, (juh) Ursel Soomets; Külli Kingo, The metabolomic profiling of psoriasis, atopic dermatitis and atherosclerosis (Psoriaasi, atoopilise dermatiidi ja ateroskleroosi metaboloomne profileerimine), Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut.
Aigar Ottas, magistrikraad, 2012, (juh) Margus Pooga; Mats Hansen; Kalle Kilk, Mitokondrisse sisenevate antioksüdantsete peptiidide disain, süntees ja rakusisene lokalisatsioon, Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut.
 
 

Jooksvad projektid

Lõppenud projektid

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2021
Ilves, Liis; Ottas, Aigar; Kaldvee, Bret; Abram, Kristi; Soomets, Ursel; Zilmer, Mihkel; Reemann, Paula; Jaks, Viljar; Kingo, Külli (2021). The metabolomic analysis of skin biopsies from atopic dermatitis patients reveals hallmarks of inflammation, disrupted barrier function and oxidative stress. Acta Dermato Venereologica, 101 (2). DOI: /doi.org/10.2340/00015555-3766.
1.1.
2018
Paapstel, Kaido; Kals, Jaak; Eha, Jaan; Tootsi, Kaspar; Ottas, Aigar; Piir, Anneli; Jakobson, Meelis; Lieberg, Jüri; Zilmer, Mihkel (2018). Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis. Nutrition Metabolism and Cardiovascular Diseases, 28 (1), 44−52. DOI: 10.1016/j.numecd.2017.07.011.
1.1.
2018
Narvik, Jane; Vanaveski, Taavi; Innos, Jürgen; Philips, Mari-Anne; Ottas, Aigar; Haring, Liina; Zilmer, Mihkel; Vasar, Eero (2018). Metabolic profile associated with distinct behavioral coping strategies of 129Sv and Bl6 mice in repeated motility test. Scientific Reports, 8 (1, 3405), 1−11. DOI: 10.1038/s41598-018-21752-9.
1.1.
2018
Kilk, Kalle; Aug, Argo; Ottas, Aigar; Soomets, Ursel; Altraja, Siiri; Altraja, Alan (2018). Phenotyping of Chronic Obstructive Pulmonary Disease Based on the Integration of Metabolomes and Clinical Characteristics. International Journal of Molecular Sciences, 19 (3), ARTN 666. DOI: 10.3390/ijms19030666.
1.1.
2017
Ottas, Aigar; Fishman, Dmytro; Okas, Tiia-Linda; Kingo, Külli; Soomets, Ursel; (2017).

The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease

. Archives of Dermatological Research, 309 (7), 519−528. DOI: 10.1007/s00403-017-1760-1.
1.1.
2017
Ottas, Aigar; Fishman, Dmytro; Okas, Tiia-Linda; Pussa, Tonu; Toomik, Peeter; Martson, Aare; Kingo, Kulli; Soomets, Ursel (2017).

Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation

. PLoS ONE, 12 (11), ARTN e0188580. DOI: 10.1371/journal.pone.0188580.
1.1.
2017
Kriisa, Kärt; Leppik, Liisa; Balõtšev, Roman; Ottas, Aigar; Soomets, Ursel; Koido, Kati; Volke, Vallo; Innos, Jürgen; Haring, Liina; Vasar, Eero; Zilmer, Mihkel (2017). Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. Journal of Proteome Research, 16 (10), 3558−3566. DOI: 10.1021/acs.jproteome.7b00279.
1.1.
2016
Paapstel, Kaido; Kals, Jaak; Eha, Jaan; Tootsi, Kaspar; Ottas, Aigar; Piir, Anneli; Zilmer, Mihkel (2016). Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients. IJC Metabolic & Endocrine, 11, 13−18. DOI: 10.1016/j.ijcme.2016.05.001.
1.1.
2016
Koido, K; Innos, J; Haring, L; Zilmer, M; Ottas, A; Vasar, E. (2016). Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis. Frontiers in Neuroscience, 10:331, 1−7. DOI: 10.3389/fnins.2016.00331.
7.04.2022

Aigar Ottas

https://www.etis.ee/CV/Aigar_Ottas/eng
4.07.1985
737 4414
+372 737 4414
aigar.ottas@ut.ee
Defended my Master's thesis in Molecular and Cell biology in 2012; the topic was on cell-penetrating peptides. My PhD thesis was focused on the metabolomics of skin diseases

Career

Institutions and positions
01.01.2020–31.12.2022   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Research Fellow in General Biochemistry (1,00)
01.01.2020–31.12.2022   
Istituto Italiano di Tecnologia, Researcher (1,00)
01.03.2018–...   
Tartu University Hospital, Biobanking and database quality assurance manager (0,50)
01.02.2018–31.08.2018   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Junior Research Fellow of Biomedicine and Translational Medicine (0,50)
01.01.2018–31.08.2018   
University of Tartu, Faculty of Medicine, Junior Researcher (0,50)
01.01.2017–31.12.2019   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Specialist (0,50)
01.01.2016–31.12.2016   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Specialist (0,50)
01.04.2015–31.12.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Specialist (0,90)
21.05.2013–31.03.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Specialist (1,00)
01.06.2012–31.12.2015   
University of Tartu, Faculty of Medicine, Department of Biochemistry, Chair of Medical Biochemistry, Specialist (0,50)
01.06.2012–20.05.2013   
University of Tartu, Faculty of Medicine, Department of Biochemistry, Specialist (1,00)
01.06.2012–31.12.2019   
University of Tartu, Faculty of Medicine, Specialist (1,00)
2007–2007   
University of Tartu, University of Tartu Natural History Museum and Botanical Garden, Museums of Tartu University, giid (1,00)
 
 
Education
2012–18.06.2019   
University of Tartu, Faculty of Medicine, PhD studies in medicine
2010–2012   
University of Tartu, Faculty of Science and Technology, Master's studies in Molecular and Cell Biology
2007–2010   
University of Tartu, Faculty of Science and Technology, Bachelor's studies in Biology
2004–2007   
University of Tartu, Faculty of Medicine, medicine
2001–2007   
Tartu Hugo Treffneri Gümnaasium
1992–2001   
Tartu Kommertsgümnaasium
 
 
R&D related managerial and administrative work
2014−2016   
Member of the council of the Institute of Biomedicine and Translational Medicine at the University of Tartu

Qualifications

Academic degrees
Aigar Ottas, Doctor's Degree, 2019, (sup) Ursel Soomets; Külli Kingo, The metabolomic profiling of psoriasis, atopic dermatitis and atherosclerosis, University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine.
Aigar Ottas, Master's Degree, 2012, (sup) Margus Pooga; Mats Hansen; Kalle Kilk, Mitokondrisse sisenevate antioksüdantsete peptiidide disain, süntees ja rakusisene lokalisatsioon (Design, synthesis and intracellular localisation of antioxidative mitochondria penetrating peptides), University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu.
 
 

Projects in progress

Completed projects

Publications

Category
Year
Publication
 
1.1.
2021
Ilves, Liis; Ottas, Aigar; Kaldvee, Bret; Abram, Kristi; Soomets, Ursel; Zilmer, Mihkel; Reemann, Paula; Jaks, Viljar; Kingo, Külli (2021). The metabolomic analysis of skin biopsies from atopic dermatitis patients reveals hallmarks of inflammation, disrupted barrier function and oxidative stress. Acta Dermato Venereologica, 101 (2). DOI: /doi.org/10.2340/00015555-3766.
1.1.
2018
Paapstel, Kaido; Kals, Jaak; Eha, Jaan; Tootsi, Kaspar; Ottas, Aigar; Piir, Anneli; Jakobson, Meelis; Lieberg, Jüri; Zilmer, Mihkel (2018). Inverse relations of serum phosphatidylcholines and lysophosphatidylcholines with vascular damage and heart rate in patients with atherosclerosis. Nutrition Metabolism and Cardiovascular Diseases, 28 (1), 44−52. DOI: 10.1016/j.numecd.2017.07.011.
1.1.
2018
Narvik, Jane; Vanaveski, Taavi; Innos, Jürgen; Philips, Mari-Anne; Ottas, Aigar; Haring, Liina; Zilmer, Mihkel; Vasar, Eero (2018). Metabolic profile associated with distinct behavioral coping strategies of 129Sv and Bl6 mice in repeated motility test. Scientific Reports, 8 (1, 3405), 1−11. DOI: 10.1038/s41598-018-21752-9.
1.1.
2018
Kilk, Kalle; Aug, Argo; Ottas, Aigar; Soomets, Ursel; Altraja, Siiri; Altraja, Alan (2018). Phenotyping of Chronic Obstructive Pulmonary Disease Based on the Integration of Metabolomes and Clinical Characteristics. International Journal of Molecular Sciences, 19 (3), ARTN 666. DOI: 10.3390/ijms19030666.
1.1.
2017
Ottas, Aigar; Fishman, Dmytro; Okas, Tiia-Linda; Kingo, Külli; Soomets, Ursel; (2017).

The metabolic analysis of psoriasis identifies the associated metabolites while providing computational models for the monitoring of the disease

. Archives of Dermatological Research, 309 (7), 519−528. DOI: 10.1007/s00403-017-1760-1.
1.1.
2017
Ottas, Aigar; Fishman, Dmytro; Okas, Tiia-Linda; Pussa, Tonu; Toomik, Peeter; Martson, Aare; Kingo, Kulli; Soomets, Ursel (2017).

Blood serum metabolome of atopic dermatitis: Altered energy cycle and the markers of systemic inflammation

. PLoS ONE, 12 (11), ARTN e0188580. DOI: 10.1371/journal.pone.0188580.
1.1.
2017
Kriisa, Kärt; Leppik, Liisa; Balõtšev, Roman; Ottas, Aigar; Soomets, Ursel; Koido, Kati; Volke, Vallo; Innos, Jürgen; Haring, Liina; Vasar, Eero; Zilmer, Mihkel (2017). Profiling of Acylcarnitines in First Episode Psychosis before and after Antipsychotic Treatment. Journal of Proteome Research, 16 (10), 3558−3566. DOI: 10.1021/acs.jproteome.7b00279.
1.1.
2016
Paapstel, Kaido; Kals, Jaak; Eha, Jaan; Tootsi, Kaspar; Ottas, Aigar; Piir, Anneli; Zilmer, Mihkel (2016). Metabolomic profiles of lipid metabolism, arterial stiffness and hemodynamics in male coronary artery disease patients. IJC Metabolic & Endocrine, 11, 13−18. DOI: 10.1016/j.ijcme.2016.05.001.
1.1.
2016
Koido, K; Innos, J; Haring, L; Zilmer, M; Ottas, A; Vasar, E. (2016). Taurine and Epidermal Growth Factor Belong to the Signature of First-Episode Psychosis. Frontiers in Neuroscience, 10:331, 1−7. DOI: 10.3389/fnins.2016.00331.
7.04.2022