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Alar Karis

https://www.etis.ee/CV/Alar_Karis/eng
26.03.1958
+3727363000
alar.karis@erm.ee
http://

Career

Institutions and positions
09.04.2018–...   
Estonian National Museum, Director (1,00)
01.01.2016–15.04.2018   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Professor in Developmental Biology (1,00)
2013–2018   
National Audit Office of Estonia, Auditor General (1,00)
01.02.2010–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Professor in Developmental Biology (1,00)
01.01.2008–31.01.2010   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Professor extraordinarius of Developmental Biologyof (0,10)
01.07.2007–30.06.2012   
University of Tartu, Rector (1,00)
01.02.2007–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Ecology and Earth Sciences, Professor extraordinariusof Developmental Biologyof (0,10)
01.01.2005–31.01.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Zoology and Hydrobiology, Professor extraordinarius (0,10)
01.01.2005–15.04.2018   
University of Tartu, University of Tartu, professor (1,00)
2003–2007   
Estonian University of Life Sciences, Rector's Office, Rector's Office, Other staff (1,00)
1999–2004   
University of Tartu, Faculty of Science and Technology (old), Institute of Ecology and Earth Sciences, Tartu University, Chair of Zoology, Professor (1,00)
01.01.1998–31.12.1999   
1998-1999 University of Tartu, Centre of Strategic Competence,Senior Research Fellow
01.01.1996–31.12.1998   
1996-1998 University of Tartu, Institute of Molecular and Cell Biology, Senior Research Fellow
01.01.1993–31.12.1998   
1993-1998 Erasmus University Rotterdam (Holland), Medical Faculty, Research Fellow
01.01.1992–31.12.1993   
1992-1993 National Institute for Medical Research, London, post-doc
01.01.1991–31.12.1991   
1991 University of Hamburg, Medical Faculty, Visiting Scientist
01.01.1990–31.12.1992   
1990-1992 Estonian Biocentre, Senior Research Fellow
01.01.1987–31.12.1990   
1987-1990 Estonian Biocentre, Research Fellow
01.01.1981–31.12.1987   
1981-1987 Estonian Institute of Veterinary Medicine and Animal Science, Research
 
 
Education
1976–1981   
Estonian Agricultural Academy,1981, DVM
1965–1976   
Tartu 2. Keskkool ( Miina Härma Gümnaasium)
 
 
R&D related managerial and administrative work
2020−...   
Eesti Maaülikooli nõukogu esimees
2018−...   
Muuseuminõukogu liige
2018−...   
Arhiivinõukogu liige
Advisory Board of the Business and Living Enviroment Division of the Enterprise Estonia Foundation, Member
Council of the Estonian Biocentre, Member
Council of the Institute of Molecular and Cell Biology, Member
Geeni- ja Keskkonnatehnoloogia Tippkeskuse nõukogu liige
Ethics Committee of the Estonian Genome Project, Member
Advisory Board of the Proceedings of Estonian Academy of Sciences, Member
EC FP6 Program, Expert
Council of the Archimedes Foundation, Member
Monitoring Commitee of the Estonian National Development Plan, Member
2007−2012   
Vabariigi Presidendi Mõttekoja liige
2007−2010   
Eestimaa Looduse Fondi nõukogu liige
2003−2006   
President of the Republic's Academic Council, Member

Qualifications

Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences
 
 
Additional information
cand.vet.med. (parasitology)
Institute of Experimental Veterinary Medicine of the National Academy of Belarus,1987

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2015
Saare, Merly; Lulla, Sirje; Tõnissoo, Tambet; Meier, Riho; Kask, Keiu; Ruisu, Katrin; Karis, Alar; Salumets, Andres; Pooga, Margus (2015). Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PLoS ONE, 10 (6), e0129131. DOI: 10.1371/journal.pone.0129131.
1.1.
2015
Kask, Keiu; Ruisu, Katrin; Tikker, Laura; Karis, Kirstin; Saare, Merly; Meier, Riho; Karis, Alar; Tõnissoo, Tambet; Pooga, Margus (2015). Deletion of RIC8A in neural precursor cells leads to altered neurogenesis and neonatal lethality of mouse. Developmental Neurobiology, 75 (9), 984−1002. DOI: 10.1002/dneu.22264.
1.1.
2013
Ruisu, K.; Kask, K.; Meier, R.; Saare, M.; Raid, R.; Veraksitš, A.; Karis, A.; Tõnissoo, T.; Pooga, M. (2013). Ablation of RIC8 function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death. PLoS ONE, 8 (8), e74031. DOI: 10.1371/journal.pone.0074031.
6.7.
2012
Kaasik, Aidula-Taie; Keis, Aime; Metspalu, Andres; Allik, Annely; Mölder, Ene; Leego, Erkki; Alavere, Helene; Lilienthal, Kadri Fischer, Krista; Leitsalu-Moynihan, Liis; Milani, Lili; Tammesoo, Mari-Liis; Väli-Täht, Maris; Leego, Merike; Hass, Merli; Tamm, Riin; Nikopensius, Tiit; Esko, Tõnu; Haller, Toomas (2012). Estonian Genome Center : 2001-2011. Tartu: University of Tartu.
1.1.
2010
Tõnissoo, T.; Lulla, S.; Meier, R.; Saare, M.; Ruisu, K.; Pooga, M.; Karis, A. (2010). Nucleotide exchange factor RIC-8 is indispensable in mammalian early development. Developmental Dynamics, 239 (12), 3404−3415. DOI: 10.1002/dvdy.22480.
1.1.
2009
Raid, R.; Krinka, D.; Bakhoff, L.; Abdelwahid, E.; Jokinen, E.; Kärner, M.; Malva, M.; Meier, R.; Pelliniemi, L.J.; Ploom, M.; Sizarov, A.; Pooga, M.; Karis, A. (2009). Lack of Gata3 results in conotruncal heart anomalies in mouse. Mechanisms of Development, 126, 80−89. DOI: 10.1016/j.mod.2008.10.001.
1.1.
2008
Plaas, M.; Karis, A.; Innos, J.; Rebane, E.; Baekelandt, V.; Vaarmann, A.; Luuk, H.; Vasar, E.; Koks, S. (2008). Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. Journal of Physiology and Pharmacology, 59 (2), 205−216.
1.1.
2006
Lilleväli, K.; Haugas, M.; Matilainen, T.; Pussinen, C.; Karis, A.; Salminen, M. (2006). Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mechanisms of Development, 123 (6), 415−429.
1.1.
2006
Areda, T.; Raud, S.; Philips, M.-A.; Innos, J.; Matsui, T.; Kõks, S.; Vasar, E.; Karis, A.; Asser, T. (2006). Cat odour exposure decreases exploratory activity and alters neuropeptide gene expression in CCK2 receptor deficient mice, but not in their wild-type littermates. Behavioural Brain Research, 169 (2), 212−219.
1.1.
2006
Tonissoo, T.; Koks, S.; Meier, R.; Raud, S.; Plaas, M.; Vasar, E.; Karis, A. (2006). Heterozygous mice with Ric-8 mutation exhibit impaired spatial memory and decreased anxiety. Behavioural Brain Research, 167 (1), 42−48.
1.1.
2005
Areda, T.; Koks, S.; Philips, MA.; Vasar, E.; Karis, A.; Asser, T. (2005). Alterations in opioid system of the rat brain after cat odor exposure. Neuroscience Letters, 377 (2), 136−139.
1.1.
2005
Airik, R.; Karner, M.; Karis, A.; Karner, J. (2005). Gene expression analysis of Gata3(-/-) mice by using cDNA microarray technology. Life Sciences, 76 (22), 2559−2568.
1.1.
2004
van der Wees, J.; van Looij, MAJ.; de Ruiter, MM.; Elias, H.; van der Burg, H.; Liem, SS.; Kurek, D.; Engel, JD.; Karis, A.; van Zanten, BGA.; De Zeeuw, CI.; Grosveld, FG.; van Doorninck, JH. (2004). Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder. Neurobiology of Disease, 16 (1), 169−178.
1.1.
2004
Lillevali, K.; Matilainen, T.; Karis, A.; Salminen, M. (2004). Partially overlapping expression of Gata2 and Gata3 during inner ear development. Developmental Dynamics, 231 (4), 775−781.
5.2.
2004
Areda, Tarmo; Kõks, Sulev; Vasar, Eero; Karis, Alar; Asser, Toomas (2004). Geeniekspressiooni muutused roti aju koletsüstokiniini ja endopioidide süsteemis pärast ekspositsiooni kassilõhnale. Eesti Arst, 9, 598.
1.1.
2003
Lindeboom, F.; Gillemans, N.; Karis, A.; Jaegle, M.; Meijer, D.; Grosveld, F.; Philipsen, S. (2003). A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Research, 31 (18), 5405−5412.
1.1.
2003
Tonissoo, T.; Meier, R.; Talts, K.; Plaas, M.; Karis, A. (2003). Expression of ric-8 (synembryn) gene in the nervous system of developing and adult mouse. Gene Expression Patterns, 3 (5), 591−594.
6.3.
2003
Saarma, U.; Valdmann, H.; Korsten, M.; Karis, A.; Vulla, E.; Männil, P. (2003). Mida metsaisand sööb ehk lugu karu toitumisest ja selle uurimisest [About the diet of the bear and researching of it]. Eesti Jahimees, 6, 14−17.
5.1.
2002
Talvik, H.; Joachim, A.; Karis, A. (2002). Changes in prepatent periods and species composition of Oesophagostomum spp. isolates over time. Nematology, International Journal of Fundamental and Applied Nematological Research, 4 (2), 313−314.
1.1.
2001
Valdmann, H.; Saarma, U.; Karis, A. (2001). The brown bear population in Estonia: current status and requirements for management. Ursus, 12, 31−36.
1.1.
2001
Karis, A.; Pata, I.; van Doorninck, JH.; Grosveld, F.; de Zeeuw, CI.; de Caprona, D.; Fritzsch, B. (2001). Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. Journal of Comparative Neurology, 429 (4), 615−630.
1.1.
2001
Gollner, H.; Bouwman, P.; Mangold, M.; Karis, A.; Braun, H.; Rohner, I.; Del Rey, A.; Besedovsky, HO.; Meinhardt, A.; van den Broek, M.; Cutforth, T.; Grosveld, F.; Philipsen, S.; Suske, G. (2001). Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Genes to Cells, 6 (8), 689−697.
1.1.
2001
Nawijn, MC.; Ferreira, R.; Dingjan, GM.; Kahre, O.; Drabek, D.; Karis, A.; Grosveld, F.; Hendriks, RW. (2001). Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice. Journal of Immunology, 167 (2), 715−723.
1.1.
2001
Nawijn, MC.; Dingjan, GM.; Ferreira, R.; Lambrecht, BN.; Karis, A.; Grosveld, F.; Savelkoul, H.; Hendriks, RW. (2001). Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo. Journal of Immunology, 167 (2), 724−732.
5.2.
2001
Talvik, H.; Joachim, A.; Karis, A.; Järvis, T. (2001). Determination of porcine Oesophagostomum species from faecal samples by ITS-PCR analysis. Russian Journal of Nematology, 9 (2), 164.
1.1.
2000
Whyatt, D.; Lindeboom, F.; Karis, A.; Ferreira, R.; Milot, E.; Hendriks, R.; Langeveld, A.; Gribnau, J.; Grosveld, F.; Philipse, S. (2000). An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells (vol 406, pg 519, 2000). Nature, 408 (6811), 498−498.
1.1.
2000
Whyatt, D.; Lindeboom, F.; Karis, A.; Ferreira, R.; Milot, E.; Hendriks, R.; de Bruijn, M.; Langeveld, A.; Gribnau, J.; Grosveld, F.; Philipsen, S. (2000). An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells. Nature, 406 (6795), 519−524.
1.1.
2000
Bouwman, P.; Gollner, H.; Elsasser, HP.; Eckhoff, G.; Karis, A.; Grosveld, F.; Philipsen, S.; Suske, G. (2000). Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO Journal, 19 (4), 655−661.
5.1.
2000
Whyatt, D.; Lindeboom, F.; Karis, A.; Ferreira, R.; Milot, E.; Hendricks, R.; de Bruijn, M.; Verkerk, T.; Langeveld, A.; Gribnau, J.; Grosveld, F.; Philipsen, S. (2000). REDS, a signal regulating erythroid differentiation in the erythroblastic island. Blood Cells Molecules and Diseases, 26 (5), 502−503.
5.1.
2000
Lakshmanan, G.; Crawford, SE.; Lim, KC.; Huang, XM.; Gu, Y.; Volpert, O.; Karis, A.; Grosveld, F.; Engel, JD. (2000). Gata3 deficiency leads to increased VEGF and impaired cardiovascular development. Circulation, 102 (18), 99−99.
1.1.
1999
Lakshmanan, G.; Lieuw, KH.; Lim, KC.; Gu, Y.; Grosveld, F.; Engel, JD.; Karis, A. (1999). Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus. Molecular and Cellular Biology, 19 (2), 1558−1568.
1.1.
1999
Hendriks, RW.; Nawijn, MC.; Engel, JD.; van Doorninck, H.; Grosveld, F.; Karis, A. (1999). Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. European Journal of Immunology, 29 (6), 1912−1918.
1.1.
1999
Pata, I.; Studer, M.; van Doorninck, JH.; Briscoe, J.; Kuuse, S.; Engel, JD.; Grosveld, F.; Karis, A. (1999). The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4. Development, 126 (23), 5523−5531.
1.2.
1999
van Doorninck, H.; van der Wees, J.; Karis, A.; Goedknegt, E.; Coesmans, M.; Rutteman, M.; Grosveld, F.; de Zeeuw, C. (1999). GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei. In: Journal of Neuroscience (RC12)..
1.1.
1998
Annilo, T.; Karis, A.; Hoth, S.; Rikk, T.; Kruppa, J.; Metspalu, A. (1998). Nuclear import and nucleolar accumulation of the human ribosomal protein S7 depends on both a minimal nuclear localization sequence and an adjacent basic region. Biochemical and Biophysical Research Communications, 249 (3), 759−766.
1.1.
1998
Hermans, MHA.; Ward, AC.; Antonissen, C.; Karis, A.; Lowenberg, B.; Touw, IP. (1998). Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Blood, 92 (1), 32−39.
5.1.
1998
Hermans, MHA.; Ward, AC.; Antonissen, C.; Karis, A.; Lowenberg, B.; Touw, IP. (1998). Perturbed granulopoiesis in mice with a targeted mutation in the G-CSF-R gene derived from severe chronic neutropenia. British Journal of Haematology, 102 (1), 140−141.
1.1.
1997
Marin, M.; Karis, A.; Visser, P.; Grosveld, F.; Philipsen, S. (1997). Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell, 89 (4), 619−628.
1.2.
1997
Whyatt, D. J.; Karis, A.; Harkes, I.C.; Verkerk, A.; Gillemans, N.; Elefanty, A. G.; Vairo, G.; Ploemacher, R.; Grosveld, F.; Philipsen, S. (1997). The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery. Genes and Function, 1 (1), 11−24.
5.1.
1997
Hermans, MHA.; Antonissen, C.; Karis, A.; Ward, AC.; deJongh, C.; Touw, IP. (1997). Mice with a targeted G-CSF receptor mutation derived from severe congenital neutropenia have reduced absolute neutrophil counts but are not severely neutropenic. Blood, 90 (10), 1822−1822.
1.1.
1996
Mazarakis, N.; Michalovich, D.; Karis, A.; Grosveld, F.; Galjart, N. (1996). Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNS. Genomics, 33 (2), 247−257.
1.1.
1996
Jaegle, M.; Mandemakers, W.; Broos, L.; Zwart, R.; Karis, A.; Visser, P.; Grosveld, F.; Meijer, D. (1996). The POU factor Oct-6 and Schwann cell differentiation. Science, 273 (5274), 507−510.
1.1.
1996
Hendriks, RW.; deBruijn, MFTR.; Maas, A.; Dingjan, GM.; Karis, A.; Grosveld, F. (1996). Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO Journal, 15 (18), 4862−4872.
1.1.
1995
Pandolfi, PP.; Roth, ME.; Karis, A.; Leonard, MW.; Dzierzak, E.; Grosveld, FG.; Engel, JD.; Lindenbaum, MH. (1995). Targeted disruption of the gata3 gene causes severe abnormalities in the nervous-system and in fetal liver hematopoiesis. Nature Genetics, 11 (1), 40−44.
3.4.
1995
Lieuw, K.H.; George, K.M.; Roth, E.M.; Leonard, M.W.; Pandolfi, P.P.; Lindenbaum, M.; Karis, A.; Grosveld, F.; Engel, J.D. (1995). Expression and Regulation of GATA-2 and GATA-3 in Hematopoietic and Other Cell Lineages. Biology of Hematopoiesis and Stem Cell Gene Transfer: Vol. 2 of the proceedings of the 9th Conference on Hemoglobin Switching, Orcas Island, Washington, USA. June 10-14, 1994. Toim. Stamatoyannopoulos, G. Andover: Intercept Press, 15−35.
5.1.
1994
Pandolfi, PP.; Roth, ME.; Leonard, MW.; Karis, A.; Engel, JD.; Grosveld, F.; Lindenbaum, M. (1994). Targeted disruption of the gata3 gene. Blood, 84 (10), A433−A433.
6.6.
1992
Karis, A.; Metspalu, E.; Pooga, M.; Juhkam, A.; Metspalu, A. (1992). Development, immunogenicity and protective capacity of K99/F41 pilus vaccine against colibacteriosis in calves (in russian). Biotechnology(Faisalabad), 8, 71−74.
15.02.2020

Alar Karis

https://www.etis.ee/CV/Alar_Karis/est
26.03.1958
+3727363000
alar.karis@erm.ee

Teenistuskäik

Töökohad ja ametid
09.04.2018–...   
Eesti Rahva Muuseum, direktor (1,00)
01.01.2016–15.04.2018   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut, arengubioloogia professor (1,00)
2013–2018   
Riigikontroll, Riigikontrolör (1,00)
01.02.2010–31.12.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, arengubioloogia professor (1,00)
01.01.2008–31.01.2010   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, arengubioloogia erakorraline professor (0,10)
01.07.2007–30.06.2012   
Tartu Ülikool, rektor (1,00)
01.02.2007–31.12.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Tartu Ülikooli Ökoloogia ja Maateaduste Instituut , arengubioloogia erakorraline professor (0,10)
01.01.2005–31.01.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Zooloogia ja hüdrobioloogia instituut, arengubioloogia erakorraline professor (0,10)
01.01.2005–15.04.2018   
Tartu Ülikool, arengubioloogia professor (1,00)
2003–2007   
Eesti Maaülikool, Rektori vastutusala, Rektoraat, rektor (1,00)
1999–2004   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Ökoloogia- ja Maateaduste Instituut, Zooloogia õppetool, Professor (1,00)
01.01.1998–31.12.1999   
erakorraline vanemteadur, Tartu Ülikool, Tehnoloogiakeskus,
01.01.1996–31.12.1998   
erakorraline vanemteadur, Tartu Ülikool, Molekulaar-ja rakubioloogia instituut,
01.01.1993–31.12.1998   
teadur, Erasmuse Ülikool Rotterdamis, Holland
01.01.1992–31.12.1993   
teadur, Rahvuslik Meditsiini Instituut, London, Suurbritannia
01.01.1991–31.12.1991   
külalisteadur, Hamburgi Ülikool, Saksamaa
01.01.1990–31.12.1992   
vanemteadur, TA Eesti Biokeskus
01.01.1987–31.12.1990   
teadur ,TA Eesti Biokeskus,
01.01.1981–31.12.1987   
teadur, Eesti Loomakasvatuse ja Veterinaaria Instituut
 
 
Haridustee
1976–1981   
Eesti Põllumajanduse Akadeemia (Eesti Maaülikool)
1965–1976   
Tartu 2. Keskkool ( Miina Härma Gümnaasium)
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2020−...   
Eesti Maaülikooli nõukogu esimees
2018−...   
Muuseuminõukogu liige
2018−...   
Arhiivinõukogu liige
EAS ettevõtlus- ja elukeskkonna arendusdivisjoni nõukoja liige
Eesti Biokeskuse nõukogu liige
TÜ Molekulaar-ja rakubioloogia instituudi nõukogu liige
Geeni- ja Keskkonnatehnoloogia Tippkeskuse nõukogu liige
Geenivaramu eetikakomitee liige
TA “Toimetised” nõuandva kogu liige
EL 6 raamprogrammi ekspert
Sihtasutus "Archimedes" nõukogu liige
Riikliku Arengukava seirekomisjoni liige
2007−2012   
Vabariigi Presidendi Mõttekoja liige
2007−2010   
Eestimaa Looduse Fondi nõukogu liige
2003−2006   
Vabariigi Presidendi Akadeemilise Nõukogu liige

Kvalifikatsioon

Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; TÄPSUSTUS: arengubioloogia, molekulaargeneetika, transgeenne tehnoloogia
 
 
Lisainfo
veterinaariakandidaat, 1987

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2015
Saare, Merly; Lulla, Sirje; Tõnissoo, Tambet; Meier, Riho; Kask, Keiu; Ruisu, Katrin; Karis, Alar; Salumets, Andres; Pooga, Margus (2015). Expression Pattern and Localization Dynamics of Guanine Nucleotide Exchange Factor RIC8 during Mouse Oogenesis. PLoS ONE, 10 (6), e0129131. DOI: 10.1371/journal.pone.0129131.
1.1.
2015
Kask, Keiu; Ruisu, Katrin; Tikker, Laura; Karis, Kirstin; Saare, Merly; Meier, Riho; Karis, Alar; Tõnissoo, Tambet; Pooga, Margus (2015). Deletion of RIC8A in neural precursor cells leads to altered neurogenesis and neonatal lethality of mouse. Developmental Neurobiology, 75 (9), 984−1002. DOI: 10.1002/dneu.22264.
1.1.
2013
Ruisu, K.; Kask, K.; Meier, R.; Saare, M.; Raid, R.; Veraksitš, A.; Karis, A.; Tõnissoo, T.; Pooga, M. (2013). Ablation of RIC8 function in mouse neurons leads to a severe neuromuscular phenotype and postnatal death. PLoS ONE, 8 (8), e74031. DOI: 10.1371/journal.pone.0074031.
6.7.
2012
Kaasik, Aidula-Taie; Keis, Aime; Metspalu, Andres; Allik, Annely; Mölder, Ene; Leego, Erkki; Alavere, Helene; Lilienthal, Kadri Fischer, Krista; Leitsalu-Moynihan, Liis; Milani, Lili; Tammesoo, Mari-Liis; Väli-Täht, Maris; Leego, Merike; Hass, Merli; Tamm, Riin; Nikopensius, Tiit; Esko, Tõnu; Haller, Toomas (2012). Estonian Genome Center : 2001-2011. Tartu: University of Tartu.
1.1.
2010
Tõnissoo, T.; Lulla, S.; Meier, R.; Saare, M.; Ruisu, K.; Pooga, M.; Karis, A. (2010). Nucleotide exchange factor RIC-8 is indispensable in mammalian early development. Developmental Dynamics, 239 (12), 3404−3415. DOI: 10.1002/dvdy.22480.
1.1.
2009
Raid, R.; Krinka, D.; Bakhoff, L.; Abdelwahid, E.; Jokinen, E.; Kärner, M.; Malva, M.; Meier, R.; Pelliniemi, L.J.; Ploom, M.; Sizarov, A.; Pooga, M.; Karis, A. (2009). Lack of Gata3 results in conotruncal heart anomalies in mouse. Mechanisms of Development, 126, 80−89. DOI: 10.1016/j.mod.2008.10.001.
1.1.
2008
Plaas, M.; Karis, A.; Innos, J.; Rebane, E.; Baekelandt, V.; Vaarmann, A.; Luuk, H.; Vasar, E.; Koks, S. (2008). Alpha-synuclein A30P point-mutation generates age-dependent nigrostriatal deficiency in mice. Journal of Physiology and Pharmacology, 59 (2), 205−216.
1.1.
2006
Lilleväli, K.; Haugas, M.; Matilainen, T.; Pussinen, C.; Karis, A.; Salminen, M. (2006). Gata3 is required for early morphogenesis and Fgf10 expression during otic development. Mechanisms of Development, 123 (6), 415−429.
1.1.
2006
Areda, T.; Raud, S.; Philips, M.-A.; Innos, J.; Matsui, T.; Kõks, S.; Vasar, E.; Karis, A.; Asser, T. (2006). Cat odour exposure decreases exploratory activity and alters neuropeptide gene expression in CCK2 receptor deficient mice, but not in their wild-type littermates. Behavioural Brain Research, 169 (2), 212−219.
1.1.
2006
Tonissoo, T.; Koks, S.; Meier, R.; Raud, S.; Plaas, M.; Vasar, E.; Karis, A. (2006). Heterozygous mice with Ric-8 mutation exhibit impaired spatial memory and decreased anxiety. Behavioural Brain Research, 167 (1), 42−48.
1.1.
2005
Areda, T.; Koks, S.; Philips, MA.; Vasar, E.; Karis, A.; Asser, T. (2005). Alterations in opioid system of the rat brain after cat odor exposure. Neuroscience Letters, 377 (2), 136−139.
1.1.
2005
Airik, R.; Karner, M.; Karis, A.; Karner, J. (2005). Gene expression analysis of Gata3(-/-) mice by using cDNA microarray technology. Life Sciences, 76 (22), 2559−2568.
1.1.
2004
van der Wees, J.; van Looij, MAJ.; de Ruiter, MM.; Elias, H.; van der Burg, H.; Liem, SS.; Kurek, D.; Engel, JD.; Karis, A.; van Zanten, BGA.; De Zeeuw, CI.; Grosveld, FG.; van Doorninck, JH. (2004). Hearing loss following Gata3 haploinsufficiency is caused by cochlear disorder. Neurobiology of Disease, 16 (1), 169−178.
1.1.
2004
Lillevali, K.; Matilainen, T.; Karis, A.; Salminen, M. (2004). Partially overlapping expression of Gata2 and Gata3 during inner ear development. Developmental Dynamics, 231 (4), 775−781.
5.2.
2004
Areda, Tarmo; Kõks, Sulev; Vasar, Eero; Karis, Alar; Asser, Toomas (2004). Geeniekspressiooni muutused roti aju koletsüstokiniini ja endopioidide süsteemis pärast ekspositsiooni kassilõhnale. Eesti Arst, 9, 598.
1.1.
2003
Lindeboom, F.; Gillemans, N.; Karis, A.; Jaegle, M.; Meijer, D.; Grosveld, F.; Philipsen, S. (2003). A tissue-specific knockout reveals that Gata1 is not essential for Sertoli cell function in the mouse. Nucleic Acids Research, 31 (18), 5405−5412.
1.1.
2003
Tonissoo, T.; Meier, R.; Talts, K.; Plaas, M.; Karis, A. (2003). Expression of ric-8 (synembryn) gene in the nervous system of developing and adult mouse. Gene Expression Patterns, 3 (5), 591−594.
6.3.
2003
Saarma, U.; Valdmann, H.; Korsten, M.; Karis, A.; Vulla, E.; Männil, P. (2003). Mida metsaisand sööb ehk lugu karu toitumisest ja selle uurimisest. Eesti Jahimees, 6, 14−17.
5.1.
2002
Talvik, H.; Joachim, A.; Karis, A. (2002). Changes in prepatent periods and species composition of Oesophagostomum spp. isolates over time. Nematology, International Journal of Fundamental and Applied Nematological Research, 4 (2), 313−314.
1.1.
2001
Valdmann, H.; Saarma, U.; Karis, A. (2001). The brown bear population in Estonia: current status and requirements for management. Ursus, 12, 31−36.
1.1.
2001
Karis, A.; Pata, I.; van Doorninck, JH.; Grosveld, F.; de Zeeuw, CI.; de Caprona, D.; Fritzsch, B. (2001). Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. Journal of Comparative Neurology, 429 (4), 615−630.
1.1.
2001
Gollner, H.; Bouwman, P.; Mangold, M.; Karis, A.; Braun, H.; Rohner, I.; Del Rey, A.; Besedovsky, HO.; Meinhardt, A.; van den Broek, M.; Cutforth, T.; Grosveld, F.; Philipsen, S.; Suske, G. (2001). Complex phenotype of mice homozygous for a null mutation in the Sp4 transcription factor gene. Genes to Cells, 6 (8), 689−697.
1.1.
2001
Nawijn, MC.; Ferreira, R.; Dingjan, GM.; Kahre, O.; Drabek, D.; Karis, A.; Grosveld, F.; Hendriks, RW. (2001). Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice. Journal of Immunology, 167 (2), 715−723.
1.1.
2001
Nawijn, MC.; Dingjan, GM.; Ferreira, R.; Lambrecht, BN.; Karis, A.; Grosveld, F.; Savelkoul, H.; Hendriks, RW. (2001). Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo. Journal of Immunology, 167 (2), 724−732.
5.2.
2001
Talvik, H.; Joachim, A.; Karis, A.; Järvis, T. (2001). Determination of porcine Oesophagostomum species from faecal samples by ITS-PCR analysis. Russian Journal of Nematology, 9 (2), 164.
1.1.
2000
Whyatt, D.; Lindeboom, F.; Karis, A.; Ferreira, R.; Milot, E.; Hendriks, R.; Langeveld, A.; Gribnau, J.; Grosveld, F.; Philipse, S. (2000). An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells (vol 406, pg 519, 2000). Nature, 408 (6811), 498−498.
1.1.
2000
Whyatt, D.; Lindeboom, F.; Karis, A.; Ferreira, R.; Milot, E.; Hendriks, R.; de Bruijn, M.; Langeveld, A.; Gribnau, J.; Grosveld, F.; Philipsen, S. (2000). An intrinsic but cell-nonautonomous defect in GATA-1-overexpressing mouse erythroid cells. Nature, 406 (6795), 519−524.
1.1.
2000
Bouwman, P.; Gollner, H.; Elsasser, HP.; Eckhoff, G.; Karis, A.; Grosveld, F.; Philipsen, S.; Suske, G. (2000). Transcription factor Sp3 is essential for post-natal survival and late tooth development. EMBO Journal, 19 (4), 655−661.
5.1.
2000
Whyatt, D.; Lindeboom, F.; Karis, A.; Ferreira, R.; Milot, E.; Hendricks, R.; de Bruijn, M.; Verkerk, T.; Langeveld, A.; Gribnau, J.; Grosveld, F.; Philipsen, S. (2000). REDS, a signal regulating erythroid differentiation in the erythroblastic island. Blood Cells Molecules and Diseases, 26 (5), 502−503.
5.1.
2000
Lakshmanan, G.; Crawford, SE.; Lim, KC.; Huang, XM.; Gu, Y.; Volpert, O.; Karis, A.; Grosveld, F.; Engel, JD. (2000). Gata3 deficiency leads to increased VEGF and impaired cardiovascular development. Circulation, 102 (18), 99−99.
1.1.
1999
Lakshmanan, G.; Lieuw, KH.; Lim, KC.; Gu, Y.; Grosveld, F.; Engel, JD.; Karis, A. (1999). Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus. Molecular and Cellular Biology, 19 (2), 1558−1568.
1.1.
1999
Hendriks, RW.; Nawijn, MC.; Engel, JD.; van Doorninck, H.; Grosveld, F.; Karis, A. (1999). Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. European Journal of Immunology, 29 (6), 1912−1918.
1.1.
1999
Pata, I.; Studer, M.; van Doorninck, JH.; Briscoe, J.; Kuuse, S.; Engel, JD.; Grosveld, F.; Karis, A. (1999). The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4. Development, 126 (23), 5523−5531.
1.2.
1999
van Doorninck, H.; van der Wees, J.; Karis, A.; Goedknegt, E.; Coesmans, M.; Rutteman, M.; Grosveld, F.; de Zeeuw, C. (1999). GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei. In: Journal of Neuroscience (RC12)..
1.1.
1998
Annilo, T.; Karis, A.; Hoth, S.; Rikk, T.; Kruppa, J.; Metspalu, A. (1998). Nuclear import and nucleolar accumulation of the human ribosomal protein S7 depends on both a minimal nuclear localization sequence and an adjacent basic region. Biochemical and Biophysical Research Communications, 249 (3), 759−766.
1.1.
1998
Hermans, MHA.; Ward, AC.; Antonissen, C.; Karis, A.; Lowenberg, B.; Touw, IP. (1998). Perturbed granulopoiesis in mice with a targeted mutation in the granulocyte colony-stimulating factor receptor gene associated with severe chronic neutropenia. Blood, 92 (1), 32−39.
5.1.
1998
Hermans, MHA.; Ward, AC.; Antonissen, C.; Karis, A.; Lowenberg, B.; Touw, IP. (1998). Perturbed granulopoiesis in mice with a targeted mutation in the G-CSF-R gene derived from severe chronic neutropenia. British Journal of Haematology, 102 (1), 140−141.
1.1.
1997
Marin, M.; Karis, A.; Visser, P.; Grosveld, F.; Philipsen, S. (1997). Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation. Cell, 89 (4), 619−628.
1.2.
1997
Whyatt, D. J.; Karis, A.; Harkes, I.C.; Verkerk, A.; Gillemans, N.; Elefanty, A. G.; Vairo, G.; Ploemacher, R.; Grosveld, F.; Philipsen, S. (1997). The level of the tissue-specific factor GATA-1 affects the cell-cycle machinery. Genes and Function, 1 (1), 11−24.
5.1.
1997
Hermans, MHA.; Antonissen, C.; Karis, A.; Ward, AC.; deJongh, C.; Touw, IP. (1997). Mice with a targeted G-CSF receptor mutation derived from severe congenital neutropenia have reduced absolute neutrophil counts but are not severely neutropenic. Blood, 90 (10), 1822−1822.
1.1.
1996
Mazarakis, N.; Michalovich, D.; Karis, A.; Grosveld, F.; Galjart, N. (1996). Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNS. Genomics, 33 (2), 247−257.
1.1.
1996
Jaegle, M.; Mandemakers, W.; Broos, L.; Zwart, R.; Karis, A.; Visser, P.; Grosveld, F.; Meijer, D. (1996). The POU factor Oct-6 and Schwann cell differentiation. Science, 273 (5274), 507−510.
1.1.
1996
Hendriks, RW.; deBruijn, MFTR.; Maas, A.; Dingjan, GM.; Karis, A.; Grosveld, F. (1996). Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage. EMBO Journal, 15 (18), 4862−4872.
1.1.
1995
Pandolfi, PP.; Roth, ME.; Karis, A.; Leonard, MW.; Dzierzak, E.; Grosveld, FG.; Engel, JD.; Lindenbaum, MH. (1995). Targeted disruption of the gata3 gene causes severe abnormalities in the nervous-system and in fetal liver hematopoiesis. Nature Genetics, 11 (1), 40−44.
3.4.
1995
Lieuw, K.H.; George, K.M.; Roth, E.M.; Leonard, M.W.; Pandolfi, P.P.; Lindenbaum, M.; Karis, A.; Grosveld, F.; Engel, J.D. (1995). Expression and Regulation of GATA-2 and GATA-3 in Hematopoietic and Other Cell Lineages. Biology of Hematopoiesis and Stem Cell Gene Transfer: Vol. 2 of the proceedings of the 9th Conference on Hemoglobin Switching, Orcas Island, Washington, USA. June 10-14, 1994. Toim. Stamatoyannopoulos, G. Andover: Intercept Press, 15−35.
5.1.
1994
Pandolfi, PP.; Roth, ME.; Leonard, MW.; Karis, A.; Engel, JD.; Grosveld, F.; Lindenbaum, M. (1994). Targeted disruption of the gata3 gene. Blood, 84 (10), A433−A433.
6.6.
1992
Karis, A.; Metspalu, E.; Pooga, M.; Juhkam, A.; Metspalu, A. (1992). Development, immunogenicity and protective capacity of K99/F41 pilus vaccine against colibacteriosis in calves (in russian). Biotechnology(Faisalabad), 8, 71−74.
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ProgramTypeNumberNameProject startProject endPrincipal investigatorInstitutionFinancing
SFSF0180019s11Molecular and cellular factors and mechanisms in the development of organisms01.01.201131.12.2016Margus PoogaUniversity of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu827 520,00 EUR
ETFETF6232The function of Ric-8 gene in the mouse nervous system01.01.200531.12.2007Alar KarisUniversity of Tartu, Faculty of Biology and Geography40 001,18 EUR
ETFETF7550The function of Ric-8 gene in the mouse nervous system 01.01.200831.12.2009Alar KarisUniversity of Tartu, Faculty of Biology and Geography; University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu; University of Tartu, Faculty of Science and Technology (old)43 592,85 EUR
ETFETF8427Nucleotide exchange factor (GEF) Ric-8: biological role in the mammalian gastrulation, asymmetric division, neurogenesis and behavioral physiology01.01.201031.12.2013Alar KarisUniversity of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu84 364,44 EUR
SFSF0182691s05Cellular, develomental and evolutionary factors in the development of organisms and in formation of animal biodiversity01.01.200531.12.2010Alar KarisUniversity of Tartu, Faculty of Biology and Geography; University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu; University of Tartu, Faculty of Science and Technology (old)785 824,90 EUR