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Olen nõus

Ana Rebane

https://www.etis.ee/CV/Ana_Rebane/est
11.08.1966
737 4419
ana.rebane@ut.ee
Researcher ID: D-4279-2013

Teenistuskäik

Töökohad ja ametid
01.01.2016–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, RNA bioloogia vanemteadur (1,00)
01.04.2015–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, RNA bioloogia vanemteadur (1,00)
01.08.2013–31.03.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, vanemteadur (1,00)
21.05.2013–31.07.2013   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, vanemteadur (0,20)
01.04.2012–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, vanemteadur (0,20)
01.05.2011–31.03.2012   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, vanemteadur (0,20)
01.01.2010–31.12.2013   
Šveitsi allergia ja astma instituut, külalisteadlane
01.04.2009–30.04.2011   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, vanemteadur (1,00)
01.01.2007–31.03.2009   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, erakorraline teadur (1,00)
01.01.2004–31.12.2006   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, erakorraline teadur (1,00)
01.01.2000–31.12.2003   
Yale University, järeldoktor
1999–2000   
Eesti Biokeskus, Erakorraline vanemteadur (1,00)
1989–1995   
Eesti Biokeskus, nooremteadur (1,00)
 
 
Haridustee
1995–1998   
Tartu Ülikool, TÜMRI, doktorant
1984–1989   
Tartu Ülikool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2017−...   
Journal of Allergy and Clinical Immunology, retsensentide nõukogu liige
2014−...   
Euroopa dermatoloogia teadusühingu liige
2012−...   
Euroopa allergia ja kliinilise immunoloogia ühingu liige
2010−...   
Eesti allergia ja immunoloogia ühingu liige
1999−...   
Eesti Inimesegeneetika Ühingu liige
 
 
Teenistuskäigu lisainfo
Retsenseerinud ajakirjadele:
Journal of Allergy and Clinical Immunology, Journal of investigative Dermatology, Allergy, European Journal of Immunology, European Respiratory Journal, Innate Immunity, Expert Review of Clinical Immunology, Respiratory Research, Journal of Immunology, Plos One
;

Kvalifikatsioon

Teaduskraadid
Ana Rebane, doktorikraad, 1999, (juh) Andres Metspalu, Mammalian ribosomal protein S3a genes and intron-encoded small nucleolar RNAs U73 ans U82, Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut.
 
 
Teaduspreemiad ja tunnustused
2015, Ana Rebane, Ida-Euroopa dermatoloogia-alane teaduspreemia Euroopa dermatoloogia teadlaste ühingult.
2010, Ana Rebane, SCIEX stipendim töötamiseks Sveitsi allergia ja astma instituudis 2010
2000, Ana Rebane, NATO-NSF 1 aastane järeldoktori stipendium külalisteadlastele NATO partnermaadest
1997, Ana Rebane, Soome valitsuse EV 75. aastapäeva stipendium (5 kuud) töötamiseks A. I. Virtaneni Instituudis (Kuopio Ülikool, Soome)
1996, Ana Rebane, Põhjamaade Ministrite Nõukogu stipendium (6 kuud) töötamiseks A. I. Virtaneni Instituudis (Kuopio Ülikool, Soome)
 
 
Teadustöö põhisuunad
VALDKOND: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; PÕHISUUND: Molekulaarbioloogia
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin; CERCS ERIALA: B500 Immunoloogia, seroloogia, transplantoloogia

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2018
Komlósi, Zsolt István; Kovács, Nóra; van de Veen, Willem; Kirsch, Anna; Fahrner, Heinz Benedikt; Wawrzyniak, Marcin; Rebane, Ana; Stanic, Barbara; Palomares, Oscar; Rückert, Beate; Menz, Günter; Akdis, Mübeccel; Losonczy, György; Akdis, Cezmi A. (2018). Human CD40L-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells. Journal of Allergy and Clinical Immunology.10.1016/j.jaci.2017.07.046 [ilmumas].
1.1.
2018
Carreras-Badosa, Gemma; Runnel, Toomas; Plaas, Mario; Kärner, Jaanika; Rückert, Beate; Lättekivi, Freddy; Kõks, Sulev; Akdis, Cezmi A; Kingo, Külli; Rebane, Ana (2018). microRNA-146a is linked to the production of IgE in mice but not in Atopic Dermatitis patients. Allergy.10.1111/all.13579 [ilmumas].
5.1.
2018
Kivihall A; Jakiela B; Aab A; Bochkov YA; Gern JE;Johnston S; Sanak M; Soja J; Bochenek G; Rebane A (2018). The expression and function of miR‐146a/b in human bronchial epithelial cells. Allergy, 73, 57−58.10.1111/all.13535.
1.1.
2017
Aab, Alar; Wirz, Oliver; van de Veen, Willem; Söllner, Stefan; Stanic, Barbara; Rückert, Beate; Aniscenko, Julia; Edwards, Michael R; Johnston, Sebastian L; Papadopoulos, Nikolaos G; Rebane, Ana; Akdis, Cezmi A; Akdis, Mübeccel (2017). Human Rhinoviruses Enter and Induce Proliferation of B Lymphocytes. Allergy, 72 (2), 232−243.10.1111/all.12931.
1.1.
2017
Kärner, J; Wawrzyniak, M; Tankov, S; Runnel, T; Aints, A; Kisand, K; Altraja, A; Kingo, K; Akdis, C A; Akdis, M; Rebane, A (2017). Increased microRNA-323-3p in IL-22/IL-17-producing T cells and asthma: a role in the regulation of the TGF-β pathway and IL-22 production. Allergy, 72 (1), 55−65.10.1111/all.12907.
1.1.
2017
Urgard, Egon; Reigo, Anu; Reinmaa, Eva; Rebane, Ana; Metspalu, Andres (2017). Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model. Cancer cell international, 17, 18−18.10.1186/s12935-017-0394-x.
1.1.
2017
Šahmatova, Liisi; Sügis, Elena; Šunina, Marina; Hermann, Helen; Prans, Ele; Pihlap, Maire; Abram, Kristi; Rebane, Ana; Peterson, Hedi; Peterson, Pärt; Kingo, Külli; Kisand, Kai (2017). Signs of innate immune activation and premature immunosenescence in psoriasis patients. Scientific ReportsX, 7 (1), 7553−7553.10.1038/s41598-017-07975-2.
1.1.
2017
Hermann, Helen; Runnel, Toomas; Aab, Alar; Baurecht, Hansjörg; Rodriguez, Elke; Magilnick, Nathaniel; Urgard, Egon; Šahmatova, Liisi; Prans, Ele; Maslovskaja, Julia; Abram, Kristi; Karelson, Maire; Kaldvee, Bret; Reemann, Paula; Haljasorg, Uku; Rückert, Beate; Wawrzyniak, Paulina; Weichenthal, Michael; Mrowietz, Ulrich; Franke, Andre ... (2017). miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis. Journal of Investigative Dermatology.10.1016/j.jid.2017.05.012.
1.1.
2017
Urgard, Egon; Brjalin, Aleksei; Langel, Ulo; Pooga, Margus; Rebane, Ana; Annilo, Tarmo (2017).

Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells

. Nucleic Acid Therapeutics, 27 (5), 295−302.10.1089/nat.2017.0670.
5.1.
2017
Kivihall, A.; Aab, A.; Bochkov, Y.; Hermann, H.; Runnel, T.; Gern, J.; Johnston, S.; Sanak, M.; Jakiela, B.; Rebane, A. (2017). MicroRNA-146a modulates immune responses to human rhinoviruses in primary bronchial epithelial cells. Allergy, 72, 133−133.
5.1.
2017
Hermann, H.; Runnel, T.; Sahmatova, L.; Prants, E.; Abram, K.; Kaldvee, B.; Mrowietz, U.; Weidinger, S.; Kingo, K.; Rebane, A. (2017). SERPINB2 is regulated by the NF-kappa B pathway and miR-146a in human primary keratinocytes and psoriasis. Journal of Investigative Dermatology, 137 (10), S259−S259.
1.1.
2016
Šahmatova, Liisi; Tankov, Stoyan; Prans, Ele; Aab, Alar; Hermann, Helen; Reemann, Paula; Pihlap, Maire; Karelson, Maire; Abram, Kristi; Kisand, Kai; Kingo, Külli; Rebane, Ana (2016). MicroRNA-155 is Dysregulated in the Skin of Patients with Vitiligo and Inhibits Melanogenesis-associated Genes in Melanocytes and Keratinocytes. Acta dermato-venereologica, 96, 6, 742−747.10.2340/00015555-2394.
1.1.
2016
Duan, Su; Wanke, Kerstin; Wawrzyniak, Paulina; Meng, Yifan; Kast, Jeannette I; Rückert, Beate; Rebane, Ana; Xian, Mu; Bindslev-Jensen, Carsten; Broesby, Sigurd; Raab, Ulrike; Werfel, Thomas; Akdis, Mübeccel; Zhang, Luo; Akdis, Cezmi A (2016). Platelet-activating factor decreases skin keratinocyte tight junction barrier integrity. The Journal of allergy and clinical immunology, 138 (6), 1.10.1016/j.jaci.2016.05.037.
1.1.
2016
Akdis, Mübeccel; Aab, Alar; Altunbulakli, Can; Azkur, Kursat; Costa, Rita A; Crameri, Reto; Duan, Su; Eiwegger, Thomas; Eljaszewicz, Andrzej; Ferstl, Ruth; Frei, Remo; Garbani, Mattia; Globinska, Anna; Hess, Lena; Huitema, Carly; Kubo, Terufumi; Komlosi, Zsolt; Konieczna, Patricia; Kovacs, Nora; Kucuksezer, Umut C ... Akdis, Cezmi A (2016). Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. The Journal of allergy and clinical immunology, 138 (4), 984−1010.10.1016/j.jaci.2016.06.033.
1.1.
2016
Urgard, Egon; Lorents, Annely; Klaas, Mariliis; Padari, Kärt; Viil, Janeli; Runnel, Toomas; Langel, Kent; Kingo, Külli; Tkaczyk, Eric; Langel, Ülo; Maimets, Toivo; Jaks, Viljar; Pooga, Margus; Rebane, Ana (2016). Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis. Journal of Controlled Release, 235, 195−2014.10.1016/j.jconrel.2016.06.006.
1.1.
2015
Maslovskaja, Julia; Saare, Mario; Liiv, Ingrid; Rebane, Ana; Peterson, Pärt (2015). Extended HSR/CARD domain mediates AIRE binding to DNA. Biochemical and Biophysical Research Communications, 468 (4), 913−920.10.1016/j.bbrc.2015.11.056.
3.1.
2015
Rebane, Ana (2015). microRNA and Allergy. Advances in experimental medicine and biology, 888, 331−352.10.1007/978-3-319-22671-2_17.
5.1.
2015
Hermann, H.; Runnel, T.; Aab, A.; Rueckert, B.; Sahmatova, L.; Maslovskaja, J.; Karelson, M.; Kingo, K.; Akdis, C.; Rebane, A. (2015). The function of microRNA-146 family in the regulation of proliferation of keratinocytes and psoriasis. NEW YORK: Nature Publishing Group, S8−S8. (135).
1.1.
2014
Rebane, A.; Akdis, C.A. (2014). MicroRNAs in allergy and asthma. Current Allergy and Asthma Reports, 14 (4), 424.10.1007/s11882-014-0424-x.
1.1.
2014
Rebane, A.; Runnel, T.; Aab, A.; Maslovskaja, J.; Rückert, B.; Zimmermann, M.; Plaas, M.; Kärner, J.; Treis, A.; Pihlap, M.; Haljasorg, U.; Hermann, H.; Nagy, N:; Kemeny, L.; Erm, T.; Kingo, K.; Li, M.; Boldin, M.P.; Akdis, C.A. (2014). MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes. Journal of Allergy and Clinical Immunology, 134 (4), 836−U443.10.1016/j.jaci.2014.05.022.
5.1.
2014
Hermann, Helen, Runnel, Toomas, Aab, Alar; Sahmatova, Liisi, Maslovskaja, Julia, Ruckert, Beate, Kingo, Külli, Akdis, Cezmi, Rebane, Ana (2014). P065 The function of miR-146 family in the regulation of proliferation of keratinocytes: implication in psoriasis. EXPERIMENTAL DERMATOLOGY, 23: Inflammatory Skin Disease Summit - The Translational Revolution, Austrian Acad Sci, Vienna, AUSTRIA, NOV 19-21, 2014. Ed. WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA. JOHN WILEY & SONS, INC, 10−10.
5.1.
2014
Sahmatova, L.; Rebane, A.; Kisand, K.; Prans, E.; Hermann, H.; Loite, U.; Kingo, K. (2014). The overexpression of several inflammation-, proliferation- and apoptosis-related microRNAs in the skin from patients with psoriasis. HOBOKEN: Wiley-blackwell, E127−E128. (171).
5.1.
2014
Hermann, H.; Runnel, T.; Aab, A.; Sahmatova, L.; Maslovskaja, J.; Rueckert, B.; Kingo, K.; Akdis, C. A.; Rebane, A. (2014). The function of miR-146 family in the regulation of proliferation of keratinocytes: implication in psoriasis. HOBOKEN: Wiley-blackwell, 10−10. (23).
1.1.
2013
Rebane, Ana; Akdis, A. Cezmi (2013). MicroRNAs: Essential players in the regulation of inflammation. Journal of Allergy and Clinical Immunology, 132 (1), 15−26.10.1016/j.jaci.2013.04.011.
5.1.
2013
Wawrzyniak, M.; Wawrzyniak, P.; Rueckert, B.; Rhyner, C.; Rebane, A.; Akdis, C.; Akdis, M. (2013). Isolation and characterisation of human IL-22-producing T cells. HOBOKEN: Wiley-blackwell, 664−664. (68).
1.1.
2012
Saare, M.; Rebane, A.; Rajashekar, B.; Vilo, J., Peterson, P. (2012). Autoimmune regulator is acetylated by transcription coactivator CBP/p300. Experimental and Cellular Research, 318 (14), 1767−78.
1.1.
2012
Kast, J.I.; Wanke, K.; Soyka, M.B.; Wawrzyniak, P.; Akdis, D.; Kingo, K.; Rebane, A.; Akdis, C.A. (2012). The broad spectrum of interepithelial junctions in skin and lung. Journal of Allergy and Clinical Immunology, 130, 544−547.
1.1.
2012
Rebane, A.; Zimmermann, M.; Aab, A.; Baurecht, H.; Koreck, A.; Karelson, M.; Abram, K.; Metsalu, T.; Pihlap, M.; Meyer, N.; Fölster-Holst, R.; Nagy, N.; Kemeny, L.; Kingo, K.; Vilo, J.; Illig, T.; Akdis, M.; Franke, A.; Novak, N.; Weidinger, S. ... Akdis, CA. (2012). Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology, 129 (5), 1297−306.10.1016/j.jaci.2012.02.020.
5.1.
2012
Rebane, A.; Zimmermann, M.; Aab, A.; Rueckert, B.; Baurecht, H.; Weidinger, S.; Kemeny, L.; Kingo, K.; Novak, N.; Akdis, C. (2012). From miRNA and mRNA expression profiling to function of keratinocytes in atopic dermatitis. HOBOKEN: Wiley-blackwell, 57−57. (67).
1.1.
2011
Tserel, L.; Runnel, T.; Kisand, K.; Pihlap, M.; Bakhoff, L.; Kolde, R.; Peterson, H.; Vilo, J.; Peterson, P.; Rebane, A. (2011). MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4. Journal of Biological Chemistry, 286 (30), 26487−26495.10.1074/jbc.M110.213561.
1.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tõnis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics, 11, 642.10.1186/1471-2164-11-642.
5.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tonis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Gene Expression and Epigenetic Changes in Differentiation of Human Macrophages and Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 526−526.
5.1.
2010
Rebane, Ana; Tserel, Liina; Kisand, Kai; Backhoff, Lairi; Runnel, Toomas; Kolde, Raivo; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Balanced Expression of miRNA-S Secures Differentiation and Maturation of Human Blood Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 512−513.
5.1.
2010
Maslovskaja, Julia; Rebane, Ana; Peterson, Paert (2010). AIRE-Regulated Gene Expression Mainly Occurs on Transcriptional Level and is Promoter-Independent. MALDEN: Wiley-blackwell Publishing, Inc, 488−488. (71).
5.1.
2010
Saare, Mario; Rebane, Ana; Peterson, Paert (2010). Autoimmune Regulator (AIRE) is Acetylated by Transcriptional Co-Activator P300. MALDEN: Wiley-blackwell Publishing, Inc, 492−493. (71).
5.1.
2010
Runnel, Toomas; Tserel, Liina; Kisand, Kai; Peterson, Paert; Rebane, Ana (2010). The Function of miRNA-511. MALDEN: Wiley-blackwell Publishing, Inc, 523−524. (71).
1.1.
2009
Chignola, F.; Gaetani, M.; Rebane, A.; Org, T.; Mollica, L.; Zucchelli, C.; Spitaleri, A.; Mannella, V.; Peterson, P.; Musco, G. (2009). The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Research, 37 (9), 2951−2961.
1.1.
2008
Ferguson, B.J.; Alexander, C.E.; Rossi, S.W.; Liiv, I.; Rebane, A.; Worth, C.L.; Wong, J.; Laan, M.; Peterson, P.; Jenkinson, E.J.; Anderson, G.; Scott, H.S.; Cooke, A.; Rich, T. (2008). AIRE's card revealed; A new structure for central tolerance provokes transcriptional plasticity. Journal of Biological Chemistry, 283 (3), 1723−1731.10.1074/jbc.M707211200.
1.1.
2008
Peterson, P.; Org, T.; Rebane, A. (2008). Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nature Reviews Immunology, 8 (12), 948−957.10.1038/nri2450.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta-Molecular Cell Research, 1783 (1), 74−83.10.1016/j.bbamcr.2007.09.003.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376.10.1038/embor.2008.11.
1.1.
2005
Pitkanen, J.; Rebane, A.; Rowell, J.; Murumagi, A.; Strobel, P.; Moll, K.; Heikkila, J.; Doucas, V.; Marx, A.; Peterson, P. (2005). Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochemical and Biophysical Research Communications, 333 (3), 944−953.
1.1.
2004
Rebane, A.; Aab, A.; Steitz, JA. (2004). Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. RNA-A Publication of the RNA Society, 10 (4), 590−599.
1.1.
2002
Rebane, A.; Roomere, H.; Metspalu, A. (2002). Locations of several novel 2 '-O-methylated nucleotides in human 28S rRNA. BMC Molecular Biology, 3, -.
1.1.
1999
Rebane, A.; Metspalu, A. (1999). U82, a novel snoRNA identified from the fifth intron of human and mouse nucleolin gene. Biochimica et Biophysica Acta-Gene Structure and Expression, 1446 (3), 426−430.
1.1.
1998
Rebane, A.; Tamme, R.; Laan, M.; Pata, I.; Metspalu, A. (1998). A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes. Gene, 210 (2), 255−263.
1.1.
1992
Metspalu, A.; Rebane, A.; Hoth, S.; Pooga, M.; Stahl, J.; Kruppa, J. (1992). Human ribosomal protein-s3a - cloning of the cdna and primary structure of the protein. Gene, 119 (2), 313−316.

Tööstusomand

Ana Rebane

https://www.etis.ee/CV/Ana_Rebane/eng
11.08.1966
737 4419
ana.rebane@ut.ee
Researcher ID: D-4279-2013

Career

Institution and occupation
01.01.2016–...   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Senior Research Fellow in RNA Biology (1,00)
01.04.2015–31.12.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Research Fellow in RNA BiologyRNA BiologyRNA BiologyRNA Biology (1,00)
01.08.2013–31.03.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Research Fellow (1,00)
21.05.2013–31.07.2013   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Research Fellow (0,20)
01.04.2012–20.05.2013   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Senior Research Fellow (0,20)
01.05.2011–31.03.2012   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Senior Research Fellow (0,20)
01.01.2010–31.12.2013   
Swiss Institute of Allergy and Asthma Research (SIAF), visiting scientist
01.04.2009–30.04.2011   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Senior Research Fellow (1,00)
01.01.2007–31.03.2009   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Research Fellow extraordinarius (1,00)
01.01.2004–31.12.2006   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Research Fellow extraordinarius (1,00)
01.01.2000–31.12.2003   
Yale University, postdoctoral associate
1999–2000   
Estonian Biocentre, Extraordinary Senior Researcher (1,00)
1989–1995   
Estonian Biocentre, Other staff (1,00)
 
 
Education
1995–1998   
Tartu University, Department of Biology, PhD student
1984–1989   
Tartu University, Bioorganic chemisry
 
 
R&D related managerial and administrative work
2017−...   
Journal of Allergy and Clinical Immunology, Reviewer Board Member
2014−...   
member of European Society of Dermatological Research
2012−...   
member of European Academy of Allergy and Clinical Immunology
2010−...   
member of Estonian Society of Allergy and Immunology
1999−...   
member of Estonian Society of Human Genetics
 
 
Additional career information
REVIEWER ACTIVITIES
Journal of Allergy and Clinical Immunology, Journal of investigative Dermatology, Allergy, European Journal of Immunology, European Respiratory Journal, Innate Immunity, Expert Review of Clinical Immunology, Respiratory Research, Journal of Immunology, Plos One
;

Qualifications

Academic degrees
Ana Rebane, Doctor's Degree, 1999, (sup) Andres Metspalu, Mammalian ribosomal protein S3a genes and intron-encoded small nucleolar RNAs U73 ans U82, University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology.
 
 
Honours & awards
2015, Ana Rebane, The Eastern European Dermatology Research Award 2014 "Research Fellow" from European Society of Dermatological Research
2010, Ana Rebane, SCIEX stipendium to work at Swiss Institute of Allergy and Asthma Research (SIAF)
2000, Ana Rebane, Fellowship from NATO-NSF
1997, Ana Rebane, Fellowship from Finnish Government
1996, Ana Rebane, Fellowship from Nordic Council of Ministers
 
 
Field of research
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.1. Biochemistry
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine; CERCS SPECIALTY: B500 Immunology, serology, transplantation
 
 

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2018
Komlósi, Zsolt István; Kovács, Nóra; van de Veen, Willem; Kirsch, Anna; Fahrner, Heinz Benedikt; Wawrzyniak, Marcin; Rebane, Ana; Stanic, Barbara; Palomares, Oscar; Rückert, Beate; Menz, Günter; Akdis, Mübeccel; Losonczy, György; Akdis, Cezmi A. (2018). Human CD40L-expressing type 3 innate lymphoid cells induce IL-10-producing immature transitional regulatory B cells. Journal of Allergy and Clinical Immunology.10.1016/j.jaci.2017.07.046 [forthcoming].
1.1.
2018
Carreras-Badosa, Gemma; Runnel, Toomas; Plaas, Mario; Kärner, Jaanika; Rückert, Beate; Lättekivi, Freddy; Kõks, Sulev; Akdis, Cezmi A; Kingo, Külli; Rebane, Ana (2018). microRNA-146a is linked to the production of IgE in mice but not in Atopic Dermatitis patients. Allergy.10.1111/all.13579 [forthcoming].
5.1.
2018
Kivihall A; Jakiela B; Aab A; Bochkov YA; Gern JE;Johnston S; Sanak M; Soja J; Bochenek G; Rebane A (2018). The expression and function of miR‐146a/b in human bronchial epithelial cells. Allergy, 73, 57−58.10.1111/all.13535.
1.1.
2017
Aab, Alar; Wirz, Oliver; van de Veen, Willem; Söllner, Stefan; Stanic, Barbara; Rückert, Beate; Aniscenko, Julia; Edwards, Michael R; Johnston, Sebastian L; Papadopoulos, Nikolaos G; Rebane, Ana; Akdis, Cezmi A; Akdis, Mübeccel (2017). Human Rhinoviruses Enter and Induce Proliferation of B Lymphocytes. Allergy, 72 (2), 232−243.10.1111/all.12931.
1.1.
2017
Kärner, J; Wawrzyniak, M; Tankov, S; Runnel, T; Aints, A; Kisand, K; Altraja, A; Kingo, K; Akdis, C A; Akdis, M; Rebane, A (2017). Increased microRNA-323-3p in IL-22/IL-17-producing T cells and asthma: a role in the regulation of the TGF-β pathway and IL-22 production. Allergy, 72 (1), 55−65.10.1111/all.12907.
1.1.
2017
Urgard, Egon; Reigo, Anu; Reinmaa, Eva; Rebane, Ana; Metspalu, Andres (2017). Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model. Cancer cell international, 17, 18−18.10.1186/s12935-017-0394-x.
1.1.
2017
Šahmatova, Liisi; Sügis, Elena; Šunina, Marina; Hermann, Helen; Prans, Ele; Pihlap, Maire; Abram, Kristi; Rebane, Ana; Peterson, Hedi; Peterson, Pärt; Kingo, Külli; Kisand, Kai (2017). Signs of innate immune activation and premature immunosenescence in psoriasis patients. Scientific ReportsX, 7 (1), 7553−7553.10.1038/s41598-017-07975-2.
1.1.
2017
Hermann, Helen; Runnel, Toomas; Aab, Alar; Baurecht, Hansjörg; Rodriguez, Elke; Magilnick, Nathaniel; Urgard, Egon; Šahmatova, Liisi; Prans, Ele; Maslovskaja, Julia; Abram, Kristi; Karelson, Maire; Kaldvee, Bret; Reemann, Paula; Haljasorg, Uku; Rückert, Beate; Wawrzyniak, Paulina; Weichenthal, Michael; Mrowietz, Ulrich; Franke, Andre ... (2017). miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis. Journal of Investigative Dermatology.10.1016/j.jid.2017.05.012.
1.1.
2017
Urgard, Egon; Brjalin, Aleksei; Langel, Ulo; Pooga, Margus; Rebane, Ana; Annilo, Tarmo (2017).

Comparison of Peptide- and Lipid-Based Delivery of miR-34a-5p Mimic into PPC-1 Cells

. Nucleic Acid Therapeutics, 27 (5), 295−302.10.1089/nat.2017.0670.
5.1.
2017
Kivihall, A.; Aab, A.; Bochkov, Y.; Hermann, H.; Runnel, T.; Gern, J.; Johnston, S.; Sanak, M.; Jakiela, B.; Rebane, A. (2017). MicroRNA-146a modulates immune responses to human rhinoviruses in primary bronchial epithelial cells. Allergy, 72, 133−133.
5.1.
2017
Hermann, H.; Runnel, T.; Sahmatova, L.; Prants, E.; Abram, K.; Kaldvee, B.; Mrowietz, U.; Weidinger, S.; Kingo, K.; Rebane, A. (2017). SERPINB2 is regulated by the NF-kappa B pathway and miR-146a in human primary keratinocytes and psoriasis. Journal of Investigative Dermatology, 137 (10), S259−S259.
1.1.
2016
Šahmatova, Liisi; Tankov, Stoyan; Prans, Ele; Aab, Alar; Hermann, Helen; Reemann, Paula; Pihlap, Maire; Karelson, Maire; Abram, Kristi; Kisand, Kai; Kingo, Külli; Rebane, Ana (2016). MicroRNA-155 is Dysregulated in the Skin of Patients with Vitiligo and Inhibits Melanogenesis-associated Genes in Melanocytes and Keratinocytes. Acta dermato-venereologica, 96, 6, 742−747.10.2340/00015555-2394.
1.1.
2016
Duan, Su; Wanke, Kerstin; Wawrzyniak, Paulina; Meng, Yifan; Kast, Jeannette I; Rückert, Beate; Rebane, Ana; Xian, Mu; Bindslev-Jensen, Carsten; Broesby, Sigurd; Raab, Ulrike; Werfel, Thomas; Akdis, Mübeccel; Zhang, Luo; Akdis, Cezmi A (2016). Platelet-activating factor decreases skin keratinocyte tight junction barrier integrity. The Journal of allergy and clinical immunology, 138 (6), 1.10.1016/j.jaci.2016.05.037.
1.1.
2016
Akdis, Mübeccel; Aab, Alar; Altunbulakli, Can; Azkur, Kursat; Costa, Rita A; Crameri, Reto; Duan, Su; Eiwegger, Thomas; Eljaszewicz, Andrzej; Ferstl, Ruth; Frei, Remo; Garbani, Mattia; Globinska, Anna; Hess, Lena; Huitema, Carly; Kubo, Terufumi; Komlosi, Zsolt; Konieczna, Patricia; Kovacs, Nora; Kucuksezer, Umut C ... Akdis, Cezmi A (2016). Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases. The Journal of allergy and clinical immunology, 138 (4), 984−1010.10.1016/j.jaci.2016.06.033.
1.1.
2016
Urgard, Egon; Lorents, Annely; Klaas, Mariliis; Padari, Kärt; Viil, Janeli; Runnel, Toomas; Langel, Kent; Kingo, Külli; Tkaczyk, Eric; Langel, Ülo; Maimets, Toivo; Jaks, Viljar; Pooga, Margus; Rebane, Ana (2016). Pre-administration of PepFect6-microRNA-146a nanocomplexes inhibits inflammatory responses in keratinocytes and in a mouse model of irritant contact dermatitis. Journal of Controlled Release, 235, 195−2014.10.1016/j.jconrel.2016.06.006.
1.1.
2015
Maslovskaja, Julia; Saare, Mario; Liiv, Ingrid; Rebane, Ana; Peterson, Pärt (2015). Extended HSR/CARD domain mediates AIRE binding to DNA. Biochemical and Biophysical Research Communications, 468 (4), 913−920.10.1016/j.bbrc.2015.11.056.
3.1.
2015
Rebane, Ana (2015). microRNA and Allergy. Advances in experimental medicine and biology, 888, 331−352.10.1007/978-3-319-22671-2_17.
5.1.
2015
Hermann, H.; Runnel, T.; Aab, A.; Rueckert, B.; Sahmatova, L.; Maslovskaja, J.; Karelson, M.; Kingo, K.; Akdis, C.; Rebane, A. (2015). The function of microRNA-146 family in the regulation of proliferation of keratinocytes and psoriasis. NEW YORK: Nature Publishing Group, S8−S8. (135).
1.1.
2014
Rebane, A.; Akdis, C.A. (2014). MicroRNAs in allergy and asthma. Current Allergy and Asthma Reports, 14 (4), 424.10.1007/s11882-014-0424-x.
1.1.
2014
Rebane, A.; Runnel, T.; Aab, A.; Maslovskaja, J.; Rückert, B.; Zimmermann, M.; Plaas, M.; Kärner, J.; Treis, A.; Pihlap, M.; Haljasorg, U.; Hermann, H.; Nagy, N:; Kemeny, L.; Erm, T.; Kingo, K.; Li, M.; Boldin, M.P.; Akdis, C.A. (2014). MicroRNA-146a alleviates chronic skin inflammation in atopic dermatitis through suppression of innate immune responses in keratinocytes. Journal of Allergy and Clinical Immunology, 134 (4), 836−U443.10.1016/j.jaci.2014.05.022.
5.1.
2014
Hermann, Helen, Runnel, Toomas, Aab, Alar; Sahmatova, Liisi, Maslovskaja, Julia, Ruckert, Beate, Kingo, Külli, Akdis, Cezmi, Rebane, Ana (2014). P065 The function of miR-146 family in the regulation of proliferation of keratinocytes: implication in psoriasis. EXPERIMENTAL DERMATOLOGY, 23: Inflammatory Skin Disease Summit - The Translational Revolution, Austrian Acad Sci, Vienna, AUSTRIA, NOV 19-21, 2014. Ed. WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA. JOHN WILEY & SONS, INC, 10−10.
5.1.
2014
Sahmatova, L.; Rebane, A.; Kisand, K.; Prans, E.; Hermann, H.; Loite, U.; Kingo, K. (2014). The overexpression of several inflammation-, proliferation- and apoptosis-related microRNAs in the skin from patients with psoriasis. HOBOKEN: Wiley-blackwell, E127−E128. (171).
5.1.
2014
Hermann, H.; Runnel, T.; Aab, A.; Sahmatova, L.; Maslovskaja, J.; Rueckert, B.; Kingo, K.; Akdis, C. A.; Rebane, A. (2014). The function of miR-146 family in the regulation of proliferation of keratinocytes: implication in psoriasis. HOBOKEN: Wiley-blackwell, 10−10. (23).
1.1.
2013
Rebane, Ana; Akdis, A. Cezmi (2013). MicroRNAs: Essential players in the regulation of inflammation. Journal of Allergy and Clinical Immunology, 132 (1), 15−26.10.1016/j.jaci.2013.04.011.
5.1.
2013
Wawrzyniak, M.; Wawrzyniak, P.; Rueckert, B.; Rhyner, C.; Rebane, A.; Akdis, C.; Akdis, M. (2013). Isolation and characterisation of human IL-22-producing T cells. HOBOKEN: Wiley-blackwell, 664−664. (68).
1.1.
2012
Saare, M.; Rebane, A.; Rajashekar, B.; Vilo, J., Peterson, P. (2012). Autoimmune regulator is acetylated by transcription coactivator CBP/p300. Experimental and Cellular Research, 318 (14), 1767−78.
1.1.
2012
Kast, J.I.; Wanke, K.; Soyka, M.B.; Wawrzyniak, P.; Akdis, D.; Kingo, K.; Rebane, A.; Akdis, C.A. (2012). The broad spectrum of interepithelial junctions in skin and lung. Journal of Allergy and Clinical Immunology, 130, 544−547.
1.1.
2012
Rebane, A.; Zimmermann, M.; Aab, A.; Baurecht, H.; Koreck, A.; Karelson, M.; Abram, K.; Metsalu, T.; Pihlap, M.; Meyer, N.; Fölster-Holst, R.; Nagy, N.; Kemeny, L.; Kingo, K.; Vilo, J.; Illig, T.; Akdis, M.; Franke, A.; Novak, N.; Weidinger, S. ... Akdis, CA. (2012). Mechanisms of IFN-γ-induced apoptosis of human skin keratinocytes in patients with atopic dermatitis. Journal of Allergy and Clinical Immunology, 129 (5), 1297−306.10.1016/j.jaci.2012.02.020.
5.1.
2012
Rebane, A.; Zimmermann, M.; Aab, A.; Rueckert, B.; Baurecht, H.; Weidinger, S.; Kemeny, L.; Kingo, K.; Novak, N.; Akdis, C. (2012). From miRNA and mRNA expression profiling to function of keratinocytes in atopic dermatitis. HOBOKEN: Wiley-blackwell, 57−57. (67).
1.1.
2011
Tserel, L.; Runnel, T.; Kisand, K.; Pihlap, M.; Bakhoff, L.; Kolde, R.; Peterson, H.; Vilo, J.; Peterson, P.; Rebane, A. (2011). MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4. Journal of Biological Chemistry, 286 (30), 26487−26495.10.1074/jbc.M110.213561.
1.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tõnis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics, 11, 642.10.1186/1471-2164-11-642.
5.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tonis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Gene Expression and Epigenetic Changes in Differentiation of Human Macrophages and Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 526−526.
5.1.
2010
Rebane, Ana; Tserel, Liina; Kisand, Kai; Backhoff, Lairi; Runnel, Toomas; Kolde, Raivo; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Balanced Expression of miRNA-S Secures Differentiation and Maturation of Human Blood Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 512−513.
5.1.
2010
Maslovskaja, Julia; Rebane, Ana; Peterson, Paert (2010). AIRE-Regulated Gene Expression Mainly Occurs on Transcriptional Level and is Promoter-Independent. MALDEN: Wiley-blackwell Publishing, Inc, 488−488. (71).
5.1.
2010
Saare, Mario; Rebane, Ana; Peterson, Paert (2010). Autoimmune Regulator (AIRE) is Acetylated by Transcriptional Co-Activator P300. MALDEN: Wiley-blackwell Publishing, Inc, 492−493. (71).
5.1.
2010
Runnel, Toomas; Tserel, Liina; Kisand, Kai; Peterson, Paert; Rebane, Ana (2010). The Function of miRNA-511. MALDEN: Wiley-blackwell Publishing, Inc, 523−524. (71).
1.1.
2009
Chignola, F.; Gaetani, M.; Rebane, A.; Org, T.; Mollica, L.; Zucchelli, C.; Spitaleri, A.; Mannella, V.; Peterson, P.; Musco, G. (2009). The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Research, 37 (9), 2951−2961.
1.1.
2008
Ferguson, B.J.; Alexander, C.E.; Rossi, S.W.; Liiv, I.; Rebane, A.; Worth, C.L.; Wong, J.; Laan, M.; Peterson, P.; Jenkinson, E.J.; Anderson, G.; Scott, H.S.; Cooke, A.; Rich, T. (2008). AIRE's card revealed; A new structure for central tolerance provokes transcriptional plasticity. Journal of Biological Chemistry, 283 (3), 1723−1731.10.1074/jbc.M707211200.
1.1.
2008
Peterson, P.; Org, T.; Rebane, A. (2008). Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nature Reviews Immunology, 8 (12), 948−957.10.1038/nri2450.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta-Molecular Cell Research, 1783 (1), 74−83.10.1016/j.bbamcr.2007.09.003.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376.10.1038/embor.2008.11.
1.1.
2005
Pitkanen, J.; Rebane, A.; Rowell, J.; Murumagi, A.; Strobel, P.; Moll, K.; Heikkila, J.; Doucas, V.; Marx, A.; Peterson, P. (2005). Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochemical and Biophysical Research Communications, 333 (3), 944−953.
1.1.
2004
Rebane, A.; Aab, A.; Steitz, JA. (2004). Transportins 1 and 2 are redundant nuclear import factors for hnRNP A1 and HuR. RNA-A Publication of the RNA Society, 10 (4), 590−599.
1.1.
2002
Rebane, A.; Roomere, H.; Metspalu, A. (2002). Locations of several novel 2 '-O-methylated nucleotides in human 28S rRNA. BMC Molecular Biology, 3, -.
1.1.
1999
Rebane, A.; Metspalu, A. (1999). U82, a novel snoRNA identified from the fifth intron of human and mouse nucleolin gene. Biochimica et Biophysica Acta-Gene Structure and Expression, 1446 (3), 426−430.
1.1.
1998
Rebane, A.; Tamme, R.; Laan, M.; Pata, I.; Metspalu, A. (1998). A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes. Gene, 210 (2), 255−263.
1.1.
1992
Metspalu, A.; Rebane, A.; Hoth, S.; Pooga, M.; Stahl, J.; Kruppa, J. (1992). Human ribosomal protein-s3a - cloning of the cdna and primary structure of the protein. Gene, 119 (2), 313−316.

Industrial property
Detailne otsing
  • Leitud 10 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF6490AIRE transkriptsiooni regulaatorina01.01.200531.12.2008Ana RebaneTartu Ülikool, Arstiteaduskond26 270,25 EUR
MOBJDMOBJD106Dendriitrakkudesse sisenevate peptiidide ja mikroRNA-põhiste nanopartiklite disain ja mõju põletikulistele protsessidele 15.09.201714.09.2019Gemma Carreras-BadosaTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut72 010,00 EUR
ETFETF8169Epigeneetilised regulatsioonid immuuntolerantsuses01.01.201031.12.2012Pärt PetersonTartu Ülikool, Arstiteaduskond57 542,29 EUR
TKSLTMR16142T (TK142)Genoomika ja Siirdemeditsiini Tippkeskus (TK142)01.01.201601.03.2023Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu4 474 349,50 EUR
PUT; PUT_OPPUT214MicroRNAd kui immunsüsteemi regulaatorid astmas ja atoopilises dermatiidis01.08.201331.12.2016Ana RebaneTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut238 620,00 EUR
ETFETF8350MikroRNA-d dendriitrakkudes01.01.201031.12.2013Ana RebaneTartu Ülikool, Arstiteaduskond76 694,29 EUR
PUT; PUT_OPPUT1669mikroRNA-d põletikulistes protsessides 01.01.201731.12.2020Ana RebaneTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut150 000,00 EUR
MUUMMVBS18046miR-146 perekonna mõju teist tüüpi immuunvastuse ja atoopilise dermatiidi tekkele ning ravimarenduslik potentsiaal20.12.201720.12.2020Ana RebaneTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut221 676,00 EUR
MUUSARMP12219T (3.2.0701.12-0052)miRNA-põhise asendusteraapia meetodite arendamine01.09.201231.08.2015Ana RebaneTartu Ülikool252 972,65 EUR
SFSF0180021s07Tolerantsuse mehhanismid tüümuses01.01.200731.12.2012Pärt PetersonTartu Ülikool, Arstiteaduskond527 814,01 EUR