This website uses cookies to store user session information. By using our website you consent to our terms of use. Read more
I agree

Andres Metspalu

https://www.etis.ee/CV/Andres_Metspalu/eng
11.03.1951
737 5066
506 3088 (5066)
andres.metspalu@ut.ee

Career

Institutions and positions
01.01.2021–...   
University of Tartu, Faculty of Science and Technology, Institute of Genomics, Professor of Genomics and Biobanking (0,90)
01.01.2018–...   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Professor of Biotechnology (0,10)
08.12.2010–...   
Estonian Academy of Sciences, Academician (1,00)
01.09.1992–...   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Professor of Biotechnology (0,10)
01.06.2018–31.12.2020   
University of Tartu, Institute of Genomics, Research Professor of Genomics and Biobanking (0,90)
01.01.2018–31.05.2018   
University of Tartu, Institute of Genomics, Director (0,90)
01.01.2016–25.01.2017   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Head of Chair
01.01.2016–31.12.2017   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Professor of Biotechnology (0,10)
01.01.2013–31.12.2017   
University of Tartu, Estonian Genome Center , Director (0,90)
01.09.2012–30.09.2012   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Professor
01.01.2010–31.12.2012   
University of Tartu, Estonian Genome Center , Director (0,90)
01.02.2009–31.12.2009   
University of Tartu, Estonian Genome Center , Director (0,80)
2009–31.12.2016   
Competence Centre on Health Technologies, Board member (0,10)
01.01.2008–31.01.2009   
University of Tartu, Estonian Genome Center , Director (0,90)
01.01.2008–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Head of Chair (0,10)
01.01.2008–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Professor of Biotechnology (0,10)
01.01.2008–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Academician (0,10)
01.04.2007–31.12.2007   
University of Tartu, Estonian Genome Center , Acting Director (0,10)
01.09.2006–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Head
01.01.2004–31.12.2007   
Estonian Genome Project, Member of the Board
01.09.2003–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Professor (1,00)
01.01.2002–31.12.2004   
EGeen International Inc., Foster City, CA, USA, Founder and Chief Scientific Office
01.01.1999–31.12.2000   
WHO International Agency for Research of Cancer (IARC), Lyon, France, The Visiting Scientist Award for 12 months
01.01.1999–01.01.2019   
Asper Biotech, Asper Biotech Ltd., Tartu, Estonia. Founder and Chairman of the Supervisory Board (1,00)
01.01.1996–31.12.2007   
Second appointment as Head of Molecular Diagnostics Centre at TartuUniversity Clinics
01.01.1993–31.12.1993   
Three months research grant from EEC at University of Hamburg, H. Pette Institute for Experimental Immunology.
01.01.1993–31.12.1994   
Sabbatical leave, visiting professor at Baylor College of Medicine, Dept. of Molecular and Human Genetics with Prof. C.T. Caskey.
01.01.1992–11.05.2014   
Estonian Biocentre, Head of Gene Technology Laboratory, Estonian Biocentre (0,25)
01.01.1992–11.05.2014   
Estonian Biocentre, Senior Researcher (0,25)
01.01.1991–31.12.1992   
Visiting scientist at Hamburg University, Dept. of Molecular Biology, Germany. Two months fellowship from DAAD.
01.01.1991–31.12.1991   
Visiting scientist at University of Tampere, Finland
01.01.1988–31.12.1988   
Max-Planck Institute of Molecular Genetics, West-Berlin, Germany. One month fellowship from European Molecular Biology Organization (EMBO)
01.01.1986–31.12.1992   
Research Director of the Estonian Biocentre
01.01.1985–31.12.1985   
European Molecular Biology Laboratory (EMBL), Heidelberg, Germany. Two month fellowship from European Society of Biochemistry (FEBS)
01.01.1985–31.12.1992   
Head of Laboratory of Gene Expression, Tartu University
01.01.1982–31.12.1984   
Senior scientist at the Laboratory of Molecular Biology, Tartu University
01.01.1981–31.12.1982   
IREX fellow at Columbia University, New York, USA
01.01.1976–31.12.1980   
Junior scientist at Laboratory of Molecular Biology, Tartu University
 
 
Education
1979–1979   
Ph.D. in Molecular Biology, Structure and function of the Eukaryotic ribosome, Institute of Molecular Genetics, Ukrainian Acad. Of Sciences, Kiev
01.09.1969–31.08.1976   
M.D - Tartu University, physician
 
 
R&D related managerial and administrative work
2021−...   
Expert Panel Member to evaluate the Section of Genetics in International Agency for Research on Cancer (IARC) in Lyon, France
2021−...   
Observational Study Monotoring Board (OSMB), NIA, NIH, USA, member
2019−...   
EU Cancer Mission Board
2019−...   
EIT Health Scandinavia Borad member
2019−...   
Independent Advisory Committee (IAC) for the International Cancer Genome Consortium (ICGC)
2019−...   
Towards access to at least 1 million sequenced genomes in the EU by 2022: 1M+ Genome, WP10 leader, WP12 co-leader, member of the Coordination Group
2018−...   
Nordic Society of Human Genetics and Precision Medicine Board member
2018−...   
European infrastructure for translational medicine (EATRIS) steering commitee member
2018−...   
BBMRI-ERIC Steering committee member, Estonian Biobank Node Director
2018−...   
Member of the International steering committee the Life Science Center of the Vilnius University
2017−...   
„France Médecine Génomique 2025“ member of the International Expert Panel
2016−...   
Eesti Teaduse Tippkeskuste Nõukogu esimees
2016−...   
Center of Excellence for Genomics and Translational Medicine PI
2010−...   
Member of Presidency of ScanBalt Academy
2010−...   
Estonian Academy of Sciences, member
2007−...   
EC European Stradegy Forum on Research Infrastructures Biomedical and Medical Sciences Thematic Working Group Member
2007−...   
Centre of Excellence in Genomics Board member
2006−...   
Member of ScanBalt Academy
2006−...   
“Central European Science Journal” co-editor
2004−...   
Journal “Clinical Genetics” editorial board member
2003−...   
Biotechnology Centre of Excellence, Vilnius, Lithuania, Member of the International Board
1999−...   
Member of Estonian Society of Human Genetics (EstSHG)
1995−...   
Member of American Society of Human Genetics (ASHG)
1995−...   
Member of The Human Genome Organization (HUGO)
1994−...   
Member of European Society of Human Genetics, from 2000 as a board member, from 2005 member of Executive Board member
2021−2023   
Tartu Ülikooli Loodus- ja Täppisteaduste valdkonna Genoomika Instituudi nõukogu liige
2018−2020   
ESOF 2020 Steering Commitee member
2018−2020   
The Longevity Consortium, NIA of NIH, USA, member of the SAB
2018−2018   
Review of the Qatar Genome Project (QGP) Member of the Panel, Chair was Prof. Victor Dzau, president of the Medical Academy of USA
2017−2021   
Estonian Precision Medicine Steering Committee member
2016−2018   
Euroscience Open Forum ESOF 2018 Programme Committee Chair
2015−2019   
Member of the Medical Sciences Scientific Committee of Science Europe
2015−2019   
Public Population Project in Genomics and Society (P3G) Board Member
2012−2016   
University Board member
2009−2011   
Member of Tartu University Council
2009−2015   
Competence Centre on Health Technologies; Board member
2008−2013   
European Research Council (ERC) Executive Agency LS2 Panel Expert
2007−2013   
President of Estonian Society of Human Genetics
2007−2011   
Estonian Veterinary and Food Board GMO and Innovated Food Committee Member
2006−2010   
European Science Foundation Functional Genomics Program: Member of steering committee
2005−2008   
President of European Society of Human Genetics
2005−2006   
International Scientific Review Board EC FP6 SSA and CA projects, Brussels
2003−2017   
Journal “Heredity Cancer in Clinical Practice” editorial board member
2003−2006   
Member of Estonian Council of Scientific Competence (advisory body for ministry of education and research for science policy and funding)
2003−2006   
International Congress of Genetics (Brisbane, Australia) member of the SPC.
2002−2004   
International Scientific Review Board The Wellcome Trust, UK
2001−2005   
European Science Foundation Functional Genomics Program: Member of steering committee
2001−2003   
International Scientific Review Board French Ministry of Research, France
2000−2016   
Chair SPC of GeneForum (International Genomic Congress)
2000−2000   
International Scientific Review Board Helmholtz Society, Germany
1999−1999   
HUGO WORKSHOP “DNA arrays – methods and applications” Tartu, Estonia, May 23-26, 1999 Organizing Committee Member
1998−2015   
Faculty Member of European School of Medical Genetics
1997−2000   
Member of Estonian Council of Scientific Competence (advisory body for ministry of education and research for science policy and funding)
1996−2001   
Member of Tartu University Council
1988−1990   
Member of the Expert Council of Soviet Union Human Genome program
 
 
Additional information

Qualifications

Academic degrees
Andres Metspalu, Doctor's Degree, 1979, (sup) Artur Lind, Interaction of 5S RNA, 5,8S RNA and tRNA with rat liver ribosomal proteins, Kiiev, Ukraina Teaduste Akadeemia Molekulaargeneetika Instituut.
 
 
Honours & awards
2020, Andres Metspalu, Prize of the Republic of Estonia for outstanding establishment and leadership of the Estonian Biobank and initiation of the Estonian genome project
2020, Andres Metspalu, University of Tartu badge "100 semesters at the University of Tartu"
2020, Andres Metspalu, Tartumaa Kuldse Tammeoksa Kavaler
2019, Andres Metspalu, Received “Estonian European of the Year” Award.
2017, Andres Metspalu, The Baltic Assembly Prize for Literature, the Arts and Science
2016, Andres Metspalu, Tartu University “Large Medal”
2016, Andres Metspalu, Baltman AS badge "Born fearless"
2015, Andres Metspalu, Honorary citizen of city of Tartu, Estonia
2010, Andres Metspalu, Doctor Honoris Causa of Vilnius University
2010, Andres Metspalu, Tartu Teerajaja Alley "Teerajaja"
2010, Andres Metspalu, University of Tartu Raefond Award
2006, Andres Metspalu, Tartu University “Small Medal”
2006, Andres Metspalu, Honorary membership of the Lithuanian Society of Laboratory Medicine
2003, Andres Metspalu, National Science Prize in Medicine
2003, Andres Metspalu, L'Ordre des Palmes Académiques, Chevalier
2002, Andres Metspalu, Prix de la Garantie Medicale et Chirurgicale, France
2001, Andres Metspalu, 3rd Class Order of the Estonian Red Cross
1999, Andres Metspalu, Elected as a “Man of the Year” by journal “Loop” in Estonia
1999, Andres Metspalu, International Agency for Research on Cancer in Lyon, „The Senior Visiting Scientist Award“
1980, Andres Metspalu, Soviet Estonian Prize for Sciences
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS CLASSIFICATION: B110 Bioinformatics, medical informatics, biomathematics, biometrics ; SPECIFICATION: Health, Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS CLASSIFICATION: T490 Biotechnology ; SPECIFICATION: Biotechnology
 
 
Additional information

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2022
Aasmets, Oliver; Krigul, Kertu Liis; Lüll, Kreete; Metspalu, Andres; Org, Elin (2022). Gut metagenome associations with extensive digital health data in a volunteer-based Estonian microbiome cohort. Nature Communications, 13 (1), 1−11. DOI: 10.1038/s41467-022-28464-9.
1.1.
2022
Auwerx, C.; Lepamets, M.; Sadler, M.C.; Patxot, M.; Stojanov, M.; Baud, D.; Mägi, R.; Esko, T.; Metspalu, A.; Milani, L.; Nelis, M.; Porcu, E.; Reymond, A.; Kutalik, Z. (2022). The individual and global impact of copy-number variants on complex human traits. The American Journal of Human Genetics, 109 (4), 647−668. DOI: 10.1016/j.ajhg.2022.02.010.
1.1.
2021
Wang, Heming; Noordam, Raymond; Cade, Brian E.; Schwander, Karen; Winkler, Thomas W.; Lee, Jiwon; Sung, Yun Ju; Bentley, Amy R.; Manning, Alisa K.; Aschard, Hugues; Kilpelainen, Tuomas O.; Ilkov, Marjan; Brown, Michael R.; Horimoto, Andrea R.; Richard, Melissa; Bartz, Traci M.; Vojinovic, Dina; Lim, Elise; Nierenberg, Jovia L.; Liu, Yongmei ... van Heemst, Diana (2021). Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. Molecular Psychiatry. DOI: 10.1038/s41380-021-01087-0.
1.1.
2021
Fridman, Hila; Yntema, Helger G.; Magi, Reedik; Andreson, Reidar; Metspalu, Andres; Mezzavila, Massimo; Tyler-Smith, Chris; Xue, Yali; Carmi, Shai; Levy-Lahad, Ephrat; Gilissen, Christian; Brunner, Han G. (2021). The landscape of autosomal-recessive pathogenic variants in European populations reveals phenotype-specific effects. The American Journal of Human Genetics, 108 (4), 608−619. DOI: 10.1016/j.ajhg.2021.03.004.
1.1.
2021
Prins, Bram Peter; Leitsalu, Liis; Pärna, Katri; Fischer, Krista; Metspalu, Andres; Haller, Toomas; Snieder, Harold (2021). Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example. Journal of Personalized Medicine, 11 (5). DOI: 10.3390/jpm11050358.
1.1.
2021
Chen, Ji; Spracklen, Cassandra N; Marenne, Gaëlle; Varshney, Arushi; Corbin, Laura J; Luan, Jian'an; Willems, Sara M; Wu, Ying; Zhang, Xiaoshuai; Horikoshi, Momoko; Boutin, Thibaud S; Mägi, Reedik; Waage, Johannes; Li-Gao, Ruifang; Chan, Kei Hang Katie; Yao, Jie; Anasanti, Mila D; Chu, Audrey Y; Claringbould, Annique; Heikkinen, Jani ... , (2021). The trans-ancestral genomic architecture of glycemic traits. Nature Genetics. DOI: 10.1038/s41588-021-00852-9.
1.1.
2021
Zeng, Lingyao; Moser, Sylvain; Mirza-Schreiber, Nazanin; Lamina, Claudia; Coassin, Stefan; Nelson, Christopher P; Annilo, Tarmo; Franzén, Oscar; Kleber, Marcus E; Mack, Salome; Andlauer, Till F M; Jiang, Beibei; Stiller, Barbara; Li, Ling; Willenborg, Christina; Munz, Matthias; Kessler, Thorsten; Kastrati, Adnan; Laugwitz, Karl-Ludwig; Erdmann, Jeanette ... Schunkert, Heribert (2021). Cis-epistasis at the LPA locus and risk of cardiovascular diseases. Cardiovascular Research, 00, 1−15. DOI: 10.1093/cvr/cvab136.
1.1.
2021
Hemani, Gibran; Powell, Joseph E.; Wang, Huanwei; Shakhbazov, Konstantin; Westra, Harm-Jan; Esko, Tonu; Henders, Anjali K.; McRae, Allan F.; Martin, Nicholas G.; Metspalu, Andres; Franke, Lude; Montgomery, Grant W.; Goddard, Michael E.; Gibson, Greg; Yang, Jian; Visscher, Peter M. (2021). Phantom epistasis between unlinked loci. Nature, 596 (7871), E1−U5. DOI: 10.1038/s41586-021-03765-z.
1.1.
2021
Hemani, Gibran; Shakhbazov, Konstantin; Westra, Harm-Jan; Esko, Tonu; Henders, Anjali K.; McRae, Allan F.; Yang, Jian; Gibson, Greg; Martin, Nicholas G.; Metspalu, Andres; Franke, Lude; Montgomery, Grant W.; Visscher, Peter M.; Powell, Joseph E. (2021). Detection and replication of epistasis influencing transcription in humans (Retraction of 10.1038/NATURE13005, 2021). Nature, 596 (7871), 306−306. DOI: 10.1038/s41586-021-03766-y.
1.1.
2021
Ruth, Katherine S.; Day, Felix R.; Hussain, Jazib; Martinez-Marchal, Ana; Aiken, Catherine E.; Azad, Ajuna; Thompson, Deborah J.; Knoblochova, Lucie; Abe, Hironori; Tarry-Adkins, Jane L.; Gonzalez, Javier Martin; Fontanillas, Pierre; Claringbould, Annique; Bakker, Olivier B.; Sulem, Patrick; Walters, Robin G.; Terao, Chikash; Turon, Sandra; Horikoshi, Momoko; Lin, Kuang ... Perry, John R. B. (2021). Genetic insights into biological mechanisms governing human ovarian ageing. Nature, 596 (7872). DOI: 10.1038/s41586-021-03779-7.
1.1.
2021
Laisk, Triin; Lepamets, Maarja; Koel, Mariann; Abner, Erik; Metspalu, Andres; Maegi, Reedik (2021). Genome-wide association study identifies five risk loci for pernicious anemia. Nature Communications, 12 (1), ARTN 3761. DOI: 10.1038/s41467-021-24051-6.
1.1.
2021
Taba, Nele; Valge, Hanna-Kristel; Metspalu, Andres; Esko, Tonu; Wilson, James F.; Fischer, Krista; Pirastu, Nicola (2021). Mendelian Randomization Identifies the Potential Causal Impact of Dietary Patterns on Circulating Blood Metabolites. Frontiers in Genetics, 12, ARTN 738265. DOI: 10.3389/fgene.2021.738265.
1.1.
2021
Zhou, Bin; Carrillo-Larco, Rodrigo M.; Danaei, Goodarz; Riley, Leanne M.; Paciorek, Christopher J.; Stevens, Gretchen A.; Gregg, Edward W.; Bennett, James E.; Solomon, Bethlehem; Singleton, Rosie K.; Sophiea, Marisa K.; Iurilli, Maria L. C.; Lhoste, Victor P. F.; Cowan, Melanie J.; Savin, Stefan; Woodward, Mark; Balanova, Yulia; Cifkova, Renata; Damasceno, Albertino; Elliott, Paul ... Zuniga Cisneros, Julio (2021). Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants. The Lancet, 398 (10304), 957−980. DOI: 10.1016/S0140-6736(21)01330-1.
1.1.
2021
Luo, Yang; Kanai, Masahiro; Choi, Wanson; Li, Xinyi; Sakaue, Saori; Yamamoto, Kenichi; Ogawa, Kotaro; Gutierrez-Arcelus, Maria; Gregersen, Peter K.; Stuart, Philip E.; Elder, James T.; Forer, Lukas; Schoenherr, Sebastian; Fuchsberger, Christian; Smith, Albert V.; Fellay, Jacques; Carrington, Mary; Haas, David W.; Guo, Xiuqing; Palmer, Nicholette D. ... Raychaudhuri, Soumya (2021). A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response. Nature Genetics, 53 (10), 1504−1516. DOI: 10.1038/s41588-021-00935-7.
1.1.
2021
Nikopensius, Tiit; Niibo, Priit; Haller, Toomas; Jagomagi, Triin; Voog-Oras, Ulle; Tonisson, Neeme; Metspalu, Andres; Saag, Mare; Pruunsild, Chris (2021). Association analysis of juvenile idiopathic arthritis genetic susceptibility factors in Estonian patients. Clinical Rheumatology. DOI: 10.1007/s10067-021-05756-x.
1.1.
2021
Iurilli, Maria L. C.; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino; Chirita-Emandi, Adela; Hayes, Alison J.; Ikeda, Nayu ... Filippi, Sarah (2021). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC). eLife, 10 (e60060), ARTN e60060. DOI: 10.7554/eLife.60060.
1.1.
2021
Andlauer, Till F. M.; Guzman-Parra, Jose; Streit, Fabian; Strohmaier, Jana; González, Maria José; Gil Flores, Susana; Cabaleiro Fabeiro, Francisco J.; del Río Noriega, Francisco; Perez, Fermin Perez; Haro González, Jesus; Orozco Diaz, Guillermo; de Diego-Otero, Yolanda; Moreno-Küstner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C. ... Rietschel, Marcella (2021). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, online. DOI: 10.1038/s41380-019-0558-2.
1.1.
2021
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei ... Fornage, Myriam (2021). Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry, 26, 2111−2125. DOI: 10.1038/s41380-020-0719-3.
1.1.
2021
Leitsalu, Liis; Palover, Marili; Sikka, Timo Tõnis; Reigo, Anu; Kals, Mart; Pärn, Kalle; Nikopensius, Tiit; Esko, Tõnu; Metspalu, Andres; Padrik, Peeter; Tõnisson, Neeme (2021). Genotype-first approach to the detection of hereditary breast and ovarian cancer risk, and effects of risk disclosure to biobank participants. European Journal of Human Genetics, 29, 471−481. DOI: 10.1038/s41431-020-00760-2.
1.1.
2021
Min, Josine L.; Hemani, Gibran; Hannon, Eilis; Dekkers, Koen F.; Castillo-Fernandez, Juan; Luijk, Rene; Carnero-Montoro, Elena; Lawson, Daniel J.; Burrows, Kimberley; Suderman, Matthew; Bretherick, Andrew D.; Richardson, Tom G.; Klughammer, Johanna; Iotchkova, Valentina; Sharp, Gemma; Al Khleifat, Ahmad; Shatunov, Aleksey; Iacoangeli, Alfredo; McArdle, Wendy L.; Ho, Karen M. ... Relton, Caroline L. (2021). Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation. Nature Genetics, 53 (9), 1311−1321. DOI: 10.1038/s41588-021-00923-x.
1.1.
2021
Munn-Chernoff, Melissa A.; Johnson, Emma C.; Chou, Yi-Ling; Coleman, Jonathan R. I.; Thornton, Laura M.; Walters, Raymond K.; Yilmaz, Zeynep; Baker, Jessica H.; Hubel, Christopher; Gordon, Scott; Medland, Sarah E.; Watson, Hunna J.; Gaspar, Helena A.; Bryois, Julien; Hinney, Anke; Leppa, Virpi M.; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodriguez, Paola ... Agrawal, Arpana (2021). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, 26 (1), ARTN e12880. DOI: 10.1111/adb.12880.
1.1.
2021
Lagou, Vasiliki; Maegi, Reedik; Hottenga, Jouke- Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gadin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amelie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron ... Prokopenko, Inga (2021). Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability. Nature Communications, 12 (1), ARTN 24. DOI: 10.1038/s41467-020-19366-9.
1.1.
2021
Cuellar-Partida, Gabriel; Tung, Joyce Y.; Eriksson, Nicholas; Albrecht, Eva; Aliev, Fazil; Andreassen, Ole A.; Barroso, Ines; Beckmann, Jacques S.; Boks, Marco P.; Boomsma, Dorret I.; Boyd, Heather A.; Breteler, Monique M. B.; Campbell, Harry; Chasman, Daniel I.; Cherkas, Lynn F.; Davies, Gail; de Geus, Eco J. C.; Deary, Ian J.; Deloukas, Panos; Dick, Danielle M. ... Medland, Sarah E. (2021). Genome-wide association study identifies 48 common genetic variants associated with handedness. Nature Human Behaviour, 5 (1), 59−70. DOI: 10.1038/s41562-020-00956-y.
1.1.
2021
Fridman, H.; Yntema, H.G.; Mägi, R.; Andreson, R.; Metspalu, A.; Mezzavila, M.; Tyler-Smith, C.; Xue, Y.; Carmi, S.; Levy-Lahad, E.; Gilissen, C.; Brunner, H.G. (2021). The landscape of autosomal-recessive pathogenic variants in European populations reveals phenotype-specific effects. American Journal of Human Genetics, 108 (4), 608−619. DOI: 10.1016/j.ajhg.2021.03.004.
1.1.
2021
Forstner, Andreas J.; Awasthi, Swapnil; Wolf, Christiane; Maron, Eduard; Erhardt, Angelika; Czamara, Darina; Eriksson, Elias; Lavebratt, Catharina; Allgulander, Christer; Friedrich, Nina; Becker, Jessica; Hecker, Julian; Rambau, Stefanie; Conrad, Rupert; Geiser, Franziska; McMahon, Francis J.; Moebus, Susanne; Hess, Timo; Buerfent, Benedikt C.; Hoffmann, Per ... Schumacher, Johannes (2021). Genome-wide association study of panic disorder reveals genetic overlap with neuroticism and depression. Molecular Psychiatry, 26 (8), 4179−4190. DOI: 10.1038/s41380-019-0590-2.
1.1.
2021
Guida, Florence; Tan, Vanessa Y.; Corbin, Laura J.; Smith-Byrne, Karl; Alcala, Karine; Langenberg, Claudia; Stewart, Isobel D.; Butterworth, Adam S.; Surendran, Praveen; Achaintre, David; Adamski, Jerzy; Amiano Exezarreta, Pilar; Bergmann, Manuela M.; Bull, Caroline J.; Dahm, Christina C.; Gicquiau, Audrey; Giles, Graham G.; Gunter, Marc J.; Haller, Toomas; Langhammer, Arnulf ... Johansson, Mattias (2021). The blood metabolome of incident kidney cancer: A case-control study nested within the MetKid consortium. PLoS Medicine, 18 (9), ARTN e1003786. DOI: 10.1371/journal.pmed.1003786.
1.1.
2021
Porcu, Eleonora; Sadler, Marie C.; Lepik, Kaido; Auwerx, Chiara; Wood, Andrew R.; Weihs, Antoine; Ribeiro, Diogo M.; Bandinelli, Stefania; Tanaka, Toshiko; Nauck, Matthias; Völker, Uwe; Delaneau, Olivier; Metspalu, Andres; Teumer, Alexander; Frayling, Timothy; Santoni, Federico A.; Reymond, Alexandre; Kutalik, Zoltán (2021). Differentially expressed genes reflect disease-induced rather than disease-causing changes in the transcriptome. Nature Communications, 12 (1), ARTN 5647. DOI: 10.1038/s41467-021-25805-y.
5.1.
2021
Porcu, Eleonora; Sadler, Marie C.; Lepik, Kaido; Auwerx, Chiara; Wood, Andrew R.; Weihs, Antoine; Ribeiro, Diogo M.; Bandinelli, Stefania; Tanaka, Toshiko; Nauck, Matthias; Volker, Uwe; Delaneau, Olivier; Metspalu, Andres; Teumer, Alexander; Frayling, Timothy; Santoni, Federico A.; Reymond, Alexandre; Kutalik, Zoltan (2021). Differentially Expressed Genes Reflect Disease-induced Rather than Disease-Causing Changes in the Transcriptome. Human Heredity, 85 (2), 89−89.
6.8.
2021
Lagou, Vasiliki; Magi, Reedik; Hottenga, Jouke-Jan; Grallert, Harald; Perry, John R. B.; Bouatia-Naji, Nabila; Marullo, Letizia; Rybin, Denis; Jansen, Rick; Min, Josine L.; Dimas, Antigone S.; Ulrich, Anna; Zudina, Liudmila; Gadin, Jesper R.; Jiang, Longda; Faggian, Alessia; Bonnefond, Amelie; Fadista, Joao; Stathopoulou, Maria G.; Isaacs, Aaron ... Prokopenko, Inga (2021). Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability (vol 12, 24, 2021). Nature Communications, 12 (1), ARTN 995. DOI: 10.1038/s41467-021-21276-3.
6.8.
2021
Ghini, Veronica; Abuja, Peter M.; Polasek, Ozren; Kozera, Lukasz; Laiho, Paeivi; Anton, Gabriele; Zins, Marie; Klovins, Janis; Metspalu, Andres; Wichmann, H-Erich; Gieger, Christian; Luchinat, Claudio; Zatloukal, Kurt; Turano, Paola (2021). Metabolomic Fingerprints in Large Population Cohorts: Impact of Preanalytical Heterogeneity. Clinical Chemistry, 67 (8), 1153−1155. DOI: 10.1093/clinchem/hvab092.
6.8.
2021
Luo, Yang; Kanai, Masahiro; Choi, Wanson; Li, Xinyi; Sakaue, Saori; Yamamoto, Kenichi; Ogawa, Kotaro; Gutierrez-Arcelus, Maria; Gregersen, Peter K.; Stuart, Philip E.; Elder, James T.; Forer, Lukas; Schonherr, Sebastian; Fuchsberger, Christian; Smith, Albert V.; Fellay, Jacques; Carrington, Mary; Haas, David W.; Guo, Xiuqing; Palmer, Nicholette D. ... Raychaudhuri, Soumya (2021). A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response (vol 53, pg 1504, 2021). Nature Genetics. DOI: 10.1038/s41588-021-00979-9.
6.8.
2021
Whiffin, Nicola; Armean, Irina M.; Kleinman, Aaron; Marshall, Jamie L.; Minikel, Eric V.; Goodrich, Julia K.; Quaife, Nicholas M.; Cole, Joanne B.; Wang, Qingbo; Karczewski, Konrad J.; Cummings, Beryl B.; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco A. S.; Merchant, Kalpana M.; Armean, Irina M.; Armean, Irina M. ... MacArthur, Daniel G. (2021). The effect of LRRK2 loss-of-function variants in humans (vol 26, pg 869, 2020). Nature Medicine. DOI: 10.1038/s41591-020-01185-6.
1.1.
2020
Munn-Chernoff, Melissa A; Johnson, Emma C; Chou, Yi-Ling; Coleman, Jonathan R I; Thornton, Laura M; Walters, Raymond K; Yilmaz, Zeynep; Baker, Jessica H; Hübel, Christopher; Gordon, Scott; Medland, Sarah E; Watson, Hunna J; Gaspar, Héléna A; Bryois, Julien; Hinney, Anke; Leppä, Virpi M; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola ... Agrawal, Arpana (2020). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, e12880−e12880. DOI: 10.1111/adb.12880.
1.1.
2020
Coleman, Jonathan R. I.; Peyrot, Wouter J.; Purves, Kirstin L.; Davis, Katrina A. S.; Rayner, Christopher; Choi, Shing Wan; Hubel, Christopher; Gaspar, Helena A.; Kan, Carol; Van der Auwera, Sandra; Adams, Mark James; Lyall, Donald M.; Choi, Karmel W.; Dunn, Erin C.; Vassos, Evangelos; Danese, Andrea; Maughan, Barbara; Grabe, Hans J.; Lewis, Cathryn M.; O'Reilly, Paul F. ... Sullivan, Patrick F. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry, 25 (7), 1430−1446. DOI: 10.1038/s41380-019-0546-6.
1.1.
2020
Glanville, Kylie P.; Coleman, Jonathan R., I; Hanscombe, Ken B.; Euesden, Jack; Choi, Shing Wan; Purves, Kirstin L.; Breen, Gerome; Air, Tracy M.; Andlauer, Till F. M.; Baune, Bernhard T.; Binder, Elisabeth B.; Blackwood, Douglas H. R.; Boomsma, Dorret, I; Buttenschon, Henriette N.; Colodro-Conde, Lucia; Dannlowski, Udo; Direk, Nese; Dunn, Erin C.; Forstner, Andreas J.; de Geus, Eco J. C. ... Borglum, Anders D. (2020). Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Biological Psychiatry, 87 (5), 419−430. DOI: 10.1016/j.biopsych.2019.06.031.
1.1.
2020
Fan Q; Pozarickij A; Tan NYQ; et al. (2020). Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error. Communications Biology, 1 (3), 133. DOI: 10.1038/s42003-020-0802-y.
1.1.
2020
Horgan, Denis; Metspalu, Andres; Ouillade, Marie-Christine; Athanasiou, Dimitrios; Pasi, John; Adjali, Oumeya; Harrison, Patrick; Hermans, Cedric; Codacci-Pisanelli, Giovanni; Koeva, Jasmina; Szucs, Thomas; Cursaru, Viorica; Belina, Ivica; Bernini, Chiara; Zhuang, Suijie; McMahon, Stephen; Toncheva, Draga; Thum, Thomas (2020). Propelling Healthcare with Advanced Therapy Medicinal Products: A Policy Discussion. Biomedicine Hub, 5 (3), 130−152. DOI: 10.1159/000511678.
1.1.
2020
Nuotio, Marja-Liisa; Pervjakova, Natalia; Joensuu, Anni; Karhunen, Ville; Hiekkalinna, Tero; Milani, Lili; Kettunen, Johannes; Järvelin, Marjo-Riitta; Jousilahti, Pekka; Metspalu, Andres; Salomaa, Veikko; Kristiansson, Kati; Perola, Markus (2020). An epigenome-wide association study of metabolic syndrome and its components. Scientific Reports, 10 (1), 20567. DOI: 10.1038/s41598-020-77506-z.
1.1.
2020
Pashayan, Nora; Antoniou, Antonis C.; Ivanus, Urska; Esserman, Laura J.; Easton, Douglas F.; French, David; Sroczynski, Gaby; Hall, Per; Cuzick, Jack; Evans, D. Gareth; Simard, Jacques; Garcia-Closas, Montserrat; Schmutzler, Rita; Wegwarth, Odette; Pharoah, Paul; Moorthie, Sowmiya; De Montgolfier, Sandrine; Baron, Camille; Herceg, Zdenko; Turnbull, Clare ... Widschwendter, Martin (2020). Personalized early detection and prevention of breast cancer: ENVISION consensus statement. Nature Reviews Clinical Oncology, 17 (11), 687−705. DOI: 10.1038/s41571-020-0388-9.
1.1.
2020
1.1.
2020
Rodriguez-Martinez, Andrea; Zhou, Bin; Sophiea, Marisa K; Bentham, James; Paciorek, Christopher J; Iurilli, Maria LC; Carrillo-Larco, Rodrigo M; Bennett, James E; Di Cesare, Mariachiara; Taddei, Cristina; Bixby, Honor; Stevens, Gretchen A; Riley, Leanne M; Cowan, Melanie J; Savin, Stefan; Danaei, Goodarz; Chirita-Emandi, Adela; Kengne, Andre P; Khang, Young-Ho; Laxmaiah, Avula ... Ezzati, Majid (2020). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. The Lancet, 396 (10261), 1511−1524. DOI: 10.1016/S0140-6736(20)31859-6.
1.1.
2020
Marees, Andries T.; Gamazon, Eric R.; Gerring, Zachary; Vorspan, Florence; Fingal, Josh; van den Brink, Wim; Smit, Dirk J. A.; Verweij, Karin J. H.; Kranzler, Henry R.; Sherva, Richard; Farrer, Lindsay; Stringer, Sven; Minica, Camelia C.; Mbarek, Hamdi; Bernard, Manon; Derringer, Jaime; van Eijk, Kristel R.; Isen, Joshua D.; Loukola, Anu; Maciejewski, Dominique F. ... Derks, Eske M. (2020). Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci. Drug and Alcohol Dependence, 206, ARTN 107703. DOI: 10.1016/j.drugalcdep.2019.107703.
1.1.
2020
Krebs, Kristi; Bovijn, Jonas; Zheng, Neil; Lepamets, Maarja; Censin, Jenny C; Jürgenson, Tuuli; Särg, Dage; Abner, Erik; Laisk, Triin; Luo, Yang; Skotte, Line; Geller, Frank; Feenstra, Bjarke; Wang, Wei; Auton, Adam; ,; Raychaudhuri, Soumya; Esko, Tõnu; Metspalu, Andres; Laur, Sven ... Fadista, João (2020). Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy. The American Journal of Human Genetics, 107 (4), 612−621. DOI: 10.1016/j.ajhg.2020.08.008.
1.1.
2020
Orthofer, Michael; Valsesia, Armand; Maegi, Reedik; Wang, Qiao-Ping; Kaczanowska, Joanna; Kozieradzki, Ivona; Leopoldi, Alexandra; Cikes, Domagoj; Zopf, Lydia M.; Tretiakov, Evgenii O.; Demetz, Egon; Hilbe, Richard; Boehm, Anna; Ticevic, Melita; Noukas, Margit; Jais, Alexander; Spirk, Katrin; Clark, Teleri; Amann, Sabine; Lepamets, Maarja ... Penninger, Josef M. (2020). Identification of ALK in Thinness. Cell, 181 (6), 1246−1285. DOI: 10.1016/j.cell.2020.04.034.
1.1.
2020
Li C, Stoma S, Lotta LA, Warner S, Albrecht E, et al. (2020). Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. The American Journal of Human Genetics, 106 (3), 389−404. DOI: 10.1016/j.ajhg.2020.02.006.
1.1.
2020
Saar, Aet; Läll, Kristi; Alver, Maris; Marandi, Toomas; Ainla, Tiia; Eha, Jaan; Metspalu, Andres; Fischer, Krista (2020). Estimating the performance of three cardiovascular disease risk scores: the Estonian Biobank cohort study. Journal of Epidemiology & Community Health, 73 (3). DOI: 10.1136/jech-2017-209965.
1.1.
2020
Pankratov, V.; Montinaro, F.; Kushniarevich, A.; Hudjashov, G.; Jay, F.; Saag, L.; Flores, R.; Marnetto, D.; Seppel, M.; Kals, M.; Võsa, U.; Taccioli, C.; Möls, M.; Milani, L.; Aasa, A.; Lawson, D.J.; Esko, T.; Mägi, R.; Pagani, L.; Metspalu, A. ... Metspalu, M. (2020). Differences in local population history at the finest level: the case of the Estonian population. European Journal of Human Genetics, 28 (11), 1580−1591. DOI: 10.1038/s41431-020-0699-4.
1.1.
2020
Erzurumluoglu, A. Mesut; Liu, Mengzhen; Jackson, Victoria E.; Barnes, Daniel R.; Datta, Gargi; Melbourne, Carl A.; Young, Robin; Batini, Chiara; Surendran, Praveen; Jiang, Tao; Adnan, Sheikh Daud; Afaq, Saima; Agrawal, Arpana; Altmaier, Elisabeth; Antoniou, Antonis C.; Asselbergs, Folkert W.; Baumbach, Clemens; Bierut, Laura; Bertelsen, Sarah; Boehnke, Michael ... Howson, Joanna M. M. (2020). Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Molecular Psychiatry, 25 (10), 2392−2409. DOI: 10.1038/s41380-018-0313-0.
1.1.
2020
Orthofer, Michael; Valsesia, Armand; Maegi, Reedik; Wang, Qiao-Ping; Kaczanowska, Joanna; Kozieradzki, Ivona; Leopoldi, Alexandra; Cikes, Domagoj; Zopf, Lydia M.; Tretiakov, Evgenii O.; Demetz, Egon; Hilbe, Richard; Boehm, Anna; Ticevic, Melita; Noukas, Margit; Jais, Alexander; Spirk, Katrin; Clark, Teleri; Amann, Sabine; Lepamets, Maarja ... Penninger, Josef M. (2020). Identification of ALK in Thinness. Cell, 181 (6), 1246−+. DOI: 10.1016/j.cell.2020.04.034.
1.1.
2020
Glanville, Kylie P.; Coleman, Jonathan R., I; Hanscombe, Ken B.; Euesden, Jack; Choi, Shing Wan; Purves, Kirstin L.; Breen, Gerome; Air, Tracy M.; Andlauer, Till F. M.; Baune, Bernhard T.; Binder, Elisabeth B.; Blackwood, Douglas H. R.; Boomsma, Dorret, I; Buttenschon, Henriette N.; Colodro-Conde, Lucia; Dannlowski, Udo; Direk, Nese; Dunn, Erin C.; Forstner, Andreas J.; de Geus, Eco J. C. ... Borglum, Anders D. (2020). Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Biological Psychiatry, 87 (5), 419−430. DOI: 10.1016/j.biopsych.2019.06.031.
1.1.
2020
Marees, Andries T.; Gamazon, Eric R.; Gerring, Zachary; Vorspan, Florence; Fingal, Josh; van den Brink, Wim; Smit, Dirk J. A.; Verweij, Karin J. H.; Kranzler, Henry R.; Sherva, Richard; Farrer, Lindsay; Stringer, Sven; Minica, Camelia C.; Mbarek, Hamdi; Bernard, Manon; Derringer, Jaime; van Eijk, Kristel R.; Isen, Joshua D.; Loukola, Anu; Maciejewski, Dominique F. ... Derks, Eske M. (2020). Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci. Drug and Alcohol Dependence, 206, ARTN 107703. DOI: 10.1016/j.drugalcdep.2019.107703.
1.1.
2020
Tillmann, Taavi; Läll, Kristi; Dukes, Oliver; Veronesi, Giovanni; Pikhart, Hynek; Peasey, Anne; Kubinova, Ruzena; Kozela, Magdalena; Pajak, Andrzej; Nikitin, Yuri; Malyutina, Sofia; Metspalu, Andres; Esko, Tõnu; Fischer, Krista; Kivimäki, Mika; Bobak, Martin (2020). Development and validation of two SCORE-based cardiovascular risk prediction models for Eastern Europe: a multicohort study. European Heart Journal, 41 (35), 3325−3333. DOI: 10.1093/eurheartj/ehaa571.
1.1.
2020
Li, Chen; Stoma, Svetlana; Lotta, Luca A.; Warner, Sophie; Albrecht, Eva; Allione, Alessandra; Arp, Pascal P.; Broer, Linda; Buxton, Jessica L.; Alves, Alexessander Da Silva Couto; Deelen, Joris; Fedko, Iryna O.; Gordon, Scott D.; Jiang, Tao; Karlsson, Robert; Kerrison, Nicola; Loe, Taylor K.; Mangino, Massimo; Milaneschi, Yuri; Miraglio, Benjamin ... Codd, Veryan (2020). Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. The American Journal of Human Genetics, 106 (3), 389−404. DOI: 10.1016/j.ajhg.2020.02.006.
1.1.
2020
Hsu, Yu-Han H.; Astley, Christina M.; Cole, Joanne B.; Vedantam, Sailaja; Mercader, Josep M.; Metspalu, Andres; Fischer, Krista; Fortney, Kristen; Morgen, Eric K.; Gonzalez, Clicerio; Gonzalez, Maria E.; Esko, Tonu; Hirschhorn, Joel N. (2020). Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome. International Journal of Obesity, 44 (7), 1596−1606. DOI: 10.1038/s41366-020-0603-x.
1.1.
2020
Laisk, Triin; Soares, Ana Luiza G; Ferreira, Teresa; Painter, Jodie N; Censin, Jenny C; Laber, Samantha; Bacelis, Jonas; Chen, Chia-Yen; Lepamets, Maarja; Lin, Kuang; Liu, Siyang; Millwood, Iona Y; Ramu, Avinash; Southcombe, Jennifer; Andersen, Marianne S; Yang, Ling; Becker, Christian M; Børglum, Anders D; Gordon, Scott D; Bybjerg-Grauholm, Jonas ... Lindgren, Cecilia M (2020). The genetic architecture of sporadic and multiple consecutive miscarriage. Nature Communications, 11 (1), 5980. DOI: 10.1038/s41467-020-19742-5.
1.1.
2020
Pankratov, Vasili; Montinaro, Francesco; Kushniarevich, Alena; Hudjashov, Georgi; Jay, Flora; Saag, Lauri; Flores, Rodrigo; Marnetto, Davide; Seppel, Marten; Kals, Mart; Vosa, Urmo; Taccioli, Cristian; Mols, Mart; Milani, Lili; Aasa, Anto; Lawson, Daniel John; Esko, Tonu; Magi, Reedik; Pagani, Luca; Metspalu, Andres ... Metspalu, Mait (2020). Differences in local population history at the finest level: the case of the Estonian population. European Journal of Human Genetics, 28 (28, 11), 1580−1591. DOI: 10.1038/s41431-020-0699-4.
5.1.
2020
Allik, A.; Metspalu, A.; Leitsalu, L.; Milani, L. (2020). Experiences with public engagement: Estonian Biobank's example. European Journal of Human Genetics, 28 (SUPPL 1, 1), 8−8.
5.1.
2020
Taba, N.; Fischer, K.; Esko, T.; Metspalu, A.; Pirastu, N. (2020). Causal Relationships between Dietary Items and Blood Metabolites Using Mendelian Randomization. Human Heredity, 84 (4-5), 225−226.
5.1.
2020
Fridman, H.; Yntema, H. G.; Magi, R.; Andreson, R.; Metspalu, A.; Carmi, S.; Levy-Lahad, E.; Gilissen, C.; Brunner, H. G. (2020). The landscape of autosomal-recessive pathogenic variants in the European population. European Journal of Human Genetics, 28 (SUPPL 1, 1), 704−704.
5.1.
2020
Ose, Jennifer; Ulrich, Cornelia M.; Playdon, Mary; Boucher, Ken; Elisassen, A. Heather; Shu, Xia-Ou; Zheng, Wei; Metspalu, Andres; Esku, Tonu; Lasky-Su, Jessica; Moore, Steve; Gunter, Marc (2020). Associations of prediagnostic metabolomic profiles with colorectal cancer risk-a collaborative reanalysis within the COnsortium of METabolomic Studies (COMETS). Cancer Epidemiology Biomarkers & Prevention, 29 (9, S), 34−35.
5.1.
2020
Palover, M.; Leitsalu, L.; Sikka, T.; Reigo, A.; Nikopensius, T.; Esko, T.; Metspalu, A.; Padrik, P.; Tonisson, N. (2020). Biobank-based genotype-first model for return of actionable findings: follow-up and extended impact by cascade screening of BRCA1/2 carriers. European Journal of Human Genetics, 28 (SUPPL 1, 1), 693−694.
6.8.
2020
Zekavat, Seyedeh M.; Ruotsalainen, Sanni; Handsaker, Robert E.; Alver, Maris; Bloom, Jonathan; Poterba, Timothy; Seed, Cotton; Ernst, Jason; Chaffin, Mark; Engreitz, Jesse; Peloso, Gina M.; Manichaikul, Ani; Yang, Chaojie; Ryan, Kathleen A.; Fu, Mao; Johnson, W. Craig; Tsai, Michael; Budoff, Matthew; Vasan, Ramachandran S.; Cupples, L. Adrienne ... Natarajan, Pradeep (2020). Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (vol 9, 2606, 2018). Nature Communications, 11 (1), ARTN 1715. DOI: 10.1038/s41467-020-15236-6.
6.8.
2020
Pashayan, Nora; Antoniou, Antonis C.; Ivanus, Urska; Esserman, Laura J.; Easton, Douglas F.; French, David; Sroczynski, Gaby; Hall, Per; Cuzick, Jack; Evans, D. Gareth; Simard, Jacques; Garcia-Closas, Montserrat; Schmutzler, Rita; Wegwarth, Odette; Pharoah, Paul; Moorthie, Sowmiya; De Montgolfier, Sandrine; Baron, Camille; Herceg, Zdenko; Turnbull, Clare ... Widschwendter, Martin (2020). Personalized early detection and prevention of breast cancer: ENVISION consensus statement (vol 77, pg 635, 2020). Nature Reviews Clinical Oncology, 17 (11), 716−716. DOI: 10.1038/s41571-020-0412-0.
1.1.
2019
Läll, Kristi; Lepamets, Maarja; Palover, Marili; Esko, Tõnu; Metspalu, Andres; Tõnisson, Neeme; Padrik, Peeter; Mägi, Reedik; Fischer, Krista (2019). Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification. BMC Cancer, 19 (1), ARTN 557. DOI: 10.1186/s12885-019-5783-1.
1.1.
2019
van der Lee, Sven J.; Teunissen, Charlotte E.; Pool, Rene; Shipley, Martin J.; Teumer, Alexander; Chouraki, Vincent; van Lent, Debora Melo; Tynkkynen, Juho; Fischer, Krista; Hernesniemi, Jussi; Haller, Toomas; Singh-Manoux, Archana; Verhoeven, Aswin; Willemsen, Gonneke; de Leeuw, Francisca A.; Wagner, Holger; van Dongen, Jenny; Hertel, Johannes; Budde, Kathrin; van Dijk, Ko Willems ... van Duijn, Cornelia M. (2019). Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies (vol 14, pg 707, 2018). In: (319−319). NEW YORK: ELSEVIER SCIENCE INC. (15). DOI: 10.1016/j.jalz.2019.01.002.
1.1.
2019
Bixby, Honor; Bentham, James; Zhou, Bin; Di Cesare, Mariachiara; Paciorek, Christopher J.; Bennett, James E.; Taddei, Cristina; Stevens, Gretchen A.; Rodriguez-Martinez, Andrea; Carrillo-Larco, Rodrigo M.; Khang, Young-Ho; Soric, Maroje; Gregg, Edward W.; Miranda, J. Jaime; Bhutta, Zulfiqar A.; Savin, Stefan; Sophiea, Marisa K.; Iurilli, Maria L. C.; Solomon, Bethlehem D.; Cowan, Melanie J. ... Ezzati, Majid (2019). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature, 569 (7755), 260−281. DOI: 10.1038/s41586-019-1171-x.
1.1.
2019
Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B.; Feitosa, Mary F.; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y.; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O.; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar ... Pattaro, Cristian (2019). A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51 (6), 957−976. DOI: 10.1038/s41588-019-0407-x.
1.1.
2019
Sidorenko, Julia; Kassam, Irfahan; Kemper, Kathryn E.; Zeng, Jian; Lloyd-Jones, Luke R.; Montgomery, Grant W.; Gibson, Greg; Metspalu, Andres; Esko, Tonu; Yang, Jian; McRae, Allan F.; Visscher, Peter M. (2019). The effect of X-linked dosage compensation on complex trait variation. Nature Communications, 10, ARTN 3009. DOI: 10.1038/s41467-019-10598-y.
1.1.
2019
Brazel, David M.; Jiang, Yu; Hughey, Jordan M.; Turcot, Valerie; Zhan, Xiaowei; Gong, Jian; Batini, Chiara; Weissenkampen, J. Dylan; Liu, MengZhen; Barnes, Daniel R.; Bertelsen, Sarah; Chou, Yi-Ling; Erzurumluoglu, A. Mesut; Faul, Jessica D.; Haessler, Jeff; Hammerschlag, Anke R.; Hsu, Chris; Kapoor, Manav; Lai, Dongbing; Le, Nhung ... Tobin, Martin D. (2019). Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use. Biological Psychiatry, 85 (11), 946−955. DOI: 10.1016/j.biopsych.2018.11.024.
1.1.
2019
Njolstad, Pal Rasmus; Andreassen, Ole Andreas; Brunak, Soren; Borglum, Anders D.; Dillner, Joakim; Esko, Tonu; Franks, Paul W.; Freimer, Nelson; Groop, Leif; Heimer, Hakon; Hougaard, David M.; Hovig, Eivind; Hveem, Kristian; Jalanko, Anu; Kaprio, Jaakko; Knudsen, Gun Peggy; Melbye, Mads; Metspalu, Andres; Mortensen, Preben Bo; Palmgren, Juni ... Stefansson, Kari (2019). Roadmap for a precision-medicine initiative in the Nordic region. Nature Genetics, 51 (6), 924−930. DOI: 10.1038/s41588-019-0391-1.
1.1.
2019
Zeng, Biao; Lloyd-Jones, Luke R.; Montgomery, Grant W.; Metspalu, Andres; Esko, Tonu; Franke, Lude; Vosa, Urmo; Claringbould, Annique; Brigham, Kenneth L.; Quyyumi, Arshed A.; Idaghdour, Youssef; Yang, Jian; Visscher, Peter M.; Powell, Joseph E.; Gibson, Greg (2019). Comprehensive Multiple eQTL Detection and Its Application to GWAS Interpretation. Genetics, 212 (3), 905−918. DOI: 10.1534/genetics.119.302091.
1.1.
2019
Czamara, Darina; Eraslan, Goekcen; Page, Christian M.; Lahti, Jari; Lahti-Pulkkinen, Marius; Hamalainen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Nystad, Wenche; Haberg, Siri E.; London, Stephanie J.; O'Donnell, Kieran J.; Garg, Elika; Meaney, Michael J.; Entringer, Sonja; Wadhwa, Pathik D.; Buss, Claudia; Jones, Meaghan J. ... Sullivan, Patrick F. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications, 10 (1), 2548. DOI: 10.1038/s41467-019-10461-0.
1.1.
2019
Patel, Riyaz S.; Schmidt, Amand F.; Tragante, Vinicius; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Dube, Marie-Pierre; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behlouli, Hassan; Boeckx, Bram; Braund, Peter S. ... Asselbergs, Folkert W. (2019). Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data. Circulation Genomic and Precision Medicine, 12 (4), 161−172. DOI: 10.1161/CIRCGEN.119.002471.
1.1.
2019
Deng, Wei Q.; Mao, Shihong; Kalnapenkis, Anette; Esko, Tonu; Magi, Reedik; Pare, Guillaume; Sun, Lei (2019). Analytical strategies to include the X-chromosome in variance heterogeneity analyses: Evidence for trait-specific polygenic variance structure. Genetic Epidemiology, 43 (7), 815−830. DOI: 10.1002/gepi.22247.
1.1.
2019
Patel, Riyaz S.; Tragante, Vinicius; Schmidt, Amand F.; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behloui, Hassan; Boeckx, Bram; Braund, Peter S.; Breitling, Lutz P. ... Asselbergs, Folkert W. (2019). Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium. Circulation Genomic and Precision Medicine, 12 (4), ARTN e002470. DOI: 10.1161/CIRCGEN.119.002470.
1.1.
2019
Tedja, Milly S.; Haarman, Annechien E. G.; Meester-Smoor, Magda A.; Kaprio, Jaakko; Mackey, David A.; Guggenheim, Jeremy A.; Hammond, Christopher J.; Verhoeven, Virginie J. M.; Klaver, Caroline C. W.; Bailey-Wilson, Joan E.; Baird, Paul Nigel; Veluchamy, Amutha Barathi; Biino, Ginevra; Burdon, Kathryn P.; Campbell, Harry; Chen, Li Jia; Cheng, Ching-Yu; Chew, Emily Y.; Craig, Jamie E.; Cumberland, Phillippa M. ... Zhou, Xiangtian (2019). IMI - Myopia Genetics Report. Investigative Ophthalmology & Visual Science, 60 (3), M89−M105. DOI: 10.1167/iovs.18-25965.
1.1.
2019
Musliner, Katherine L.; Mortensen, Preben B.; McGrath, John J.; Suppli, Nis P.; Hougaard, David M.; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Andreassen, Ole; Pedersen, Carsten B.; Pedersen, Marianne G.; Mors, Ole; Nordentoft, Merete; Borglum, Anders D.; Werge, Thomas; Agerbo, Esben; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan ... Sklar, Pamela (2019). Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population. JAMA Psychiatry, 76 (5), 516−525. DOI: 10.1001/jamapsychiatry.2018.4166.
1.1.
2019
Clark, David W.; Okada, Yukinori; Moore, Kristjan H. S.; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L. K.; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M. ... Wilson, James F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, ARTN 4957. DOI: 10.1038/s41467-019-12283-6.
1.1.
2019
Polimanti, Renato; Peterson, Roseann E.; Ong, Jue-Sheng; MacGregor, Stuart; Edwards, Alexis C.; Clarke, Toni-Kim; Frank, Josef; Gerring, Zachary; Gillespie, Nathan A.; Lind, Penelope A.; Maes, Hermine H.; Martin, Nicholas G.; Mbarek, Hamdi; Medland, Sarah E.; Streit, Fabian; Agrawal, Arpana; Edenberg, Howard J.; Kendler, Kenneth S.; Lewis, Cathryn M.; Sullivan, Patrick F. ... Neale, Benjamin M. (2019). Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. Psychological Medicine, 49 (7), 1218−1226. DOI: 10.1017/S0033291719000667.
1.1.
2019
Barbu, Miruna C.; Zeng, Yanni; Shen, Xueyi; Cox, Simon R.; Clarke, Toni-Kim; Gibson, Jude; Adams, Mark J.; Johnstone, Mandy; Haley, Chris S.; Lawrie, Stephen M.; Deary, Ian J.; McIntosh, Andrew M.; Whalley, Heather C.; Agee, Michelle; Alipanahi, Babak; Auton, Adam; Bell, RobertK; Bryc, Katarzyna; Elson, Sarah L.; Fontanillas, Pierre ... Sullivan, Patrick F. (2019). Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Biological Psychiatry Cognitive Neuroscience and Neuroimaging, 4 (1), 91−100. DOI: 10.1016/j.bpsc.2018.07.006.
1.1.
2019
Foo, Jerome C.; Streit, Fabian; Frank, Josef; Witt, Stephanie H.; Treutlein, Jens; Baune, Bernhard T.; Moebus, Susanne; Joeckel, Karl-Heinz; Forstner, Andreas J.; Noethen, Markus M.; Rietschel, Marcella; Sartorius, Alexander; Kranaster, Laura; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 180 (1), 35−45. DOI: 10.1002/ajmg.b.32700.
1.1.
2019
Linner, Richard Karlsson; Biroli, Pietro; Kong, Edward; Meddens, Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Mael; Tino, Stephen P.; Abdellaoui, Abdel; Hammerschlag, Anke R.; Nivard, Michel G.; Okbay, Aysu; Rietveld, Cornelius A.; Timshel, Pascal N.; Trzaskowski, Maciej; de Vlaming, Ronald; Zund, Christian L.; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H. ... Beauchamp, Jonathan P. (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 (2), 245−261. DOI: 10.1038/s41588-018-0309-3.
1.1.
2019
Deelen, Joris; Kettunen, Johannes; Fischer, Krista; van der Spek, Ashley; Trompet, Stella; Kastenmueller, Gabi; Boyd, Andy; Zierer, Jonas; van den Akker, Erik B.; Ala-Korpela, Mika; Amin, Najaf; Demirkan, Ayse; Ghanbari, Mohsen; van Heemst, Diana; Ikram, M. Arfan; van Klinken, Jan Bert; Mooijaart, Simon P.; Peters, Annette; Salomaa, Veikko; Sattar, Naveed ... Slagboom, P. Eline (2019). A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals. Nature Communications, 10, ARTN 3346. DOI: 10.1038/s41467-019-11311-9.
1.1.
2019
Choi, Karmel W.; Chen, Chia-Yen; Stein, Murray B.; Klimentidis, Yann C.; Wang, Min-Jung; Koenen, Karestan C.; Smoller, Jordan W.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, TracyM.; Andlauer, Till F. M.; Bacanu, Silviu-Alin; Baekvad-Hansen, Marie; Beekman, Aartjan T. F. ... Sullivan, Patrick F. (2019). Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults A 2-Sample Mendelian Randomization Study. JAMA Psychiatry, 76 (4), 399−408. DOI: 10.1001/jamapsychiatry.2018.4175.
1.1.
2019
Huckins, Laura M.; Dobbyn, Amanda; Ruderfer, Douglas M.; Hoffman, Gabriel; Wang, Weiqing; Pardinas, Antonio F.; Rajagopal, Veera M.; Als, Thomas D.; Nguyen, Hoang T.; Girdhar, Kiran; Boocock, James; Roussos, Panos; Fromer, Menachem; Kramer, Robin; Domenici, Enrico; Gamazon, Eric R.; Purcell, Shaun; Demontis, Ditte; Borglum, Anders D.; Walters, James T. R. ... Sullivan, Patrick F. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51 (4), 659−677. DOI: 10.1038/s41588-019-0364-4.
1.1.
2019
Hsu, Yu-Han H; Churchhouse, Claire; Pers, Tune H; Mercader, Josep M; Metspalu, Andres; Fischer, Krista; Fortney, Kristen; Morgen, Eric K; Gonzalez, Clicerio; Gonzalez, Maria E; Esko, Tonu; Hirschhorn, Joel N (2019). PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data. PLoS Computational Biology, 15 (1), e1006734−e1006734. DOI: 10.1371/journal.pcbi.1006734.
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648. DOI: 10.1038/s41588-019-0378-y.
1.1.
2019
Adlam, David; Olson, Timothy M.; Combaret, Nicolas; Kovacic, Jason C.; Iismaa, Siiri E.; Al-Hussaini, Abtehale; O'Byrne, Megan M.; Bouajila, Sara; Georges, Adrien; Mishra, Ketan; Braund, Peter S.; d'Escamard, Valentina; Huang, Siying; Margaritis, Marios; Nelson, Christopher P.; de Andrade, Mariza; Kadian-Dodov, Daniella; Welch, Catherine A.; Mazurkiewicz, Stephani; Jeunemaitre, Xavier ... Bouatia-Naji, Nabila (2019). Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. Journal of the American College of Cardiology, 73 (1), 58−66. DOI: 10.1016/j.jacc.2018.09.085.
1.1.
2019
Grove, Jakob; Ripke, Stephan; Als, Thomas D.; Mattheisen, Manuel; Walters, Raymond K.; Won, Hyejung; Pallesen, Jonatan; Agerbo, Esben; Andreassen, Ole A.; Anney, Richard; Awashti, Swapnil; Belliveau, Rich; Bettella, Francesco; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Christensen, Jane H.; Churchhouse, Claire ... Wilson, Catherine H. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431−447. DOI: 10.1038/s41588-019-0344-8.
1.1.
2019
Virtanen, V.B.; Salo, P.P.; Cao, J.; Löf-Granström, A.; Milani, L.; Metspalu, A.; Rintala, R.J.; Saarenpää-Heikkilä, O.; Paunio, T.; Wester, T.; Nordenskjöld, A.; Perola, M.; Pakarinen, M.P. (2019). Noncoding RET variants explain the strong association with Hirschsprung disease in patients without rare coding sequence variant. European Journal of Medical Genetics, 62 (4), 229−234. DOI: 10.1016/j.ejmg.2018.07.019.
1.1.
2019
Yao, Shuyang; Kuja-Halkola, Ralf; Martin, Joanna; Lu, Yi; Lichtenstein, Paul; Norring, Claes; Birgegard, Andreas; Yilmaz, Zeynep; Hubel, Christopher; Watson, Hunna; Baker, Jessica; Almqvist, Catarina; Thornton, Laura M.; Magnusson, Patrik K.; Bulik, Cynthia M.; Larsson, Henrik; Adan, Roger; Ando, Tetsuya; Bergen, Andrew; Berrettini, Wade ... Bulik, Cynthia (2019). Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry, 86 (8), 577−586. DOI: 10.1016/j.biopsych.2019.04.036.
1.1.
2019
Lloyd-Jones, Luke R.; Zeng, Jian; Sidorenko, Julia; Yengo, Loic; Moser, Gerhard; Kemper, Kathryn E.; Wang, Huanwei; Zheng, Zhili; Magi, Reedik; Esko, Tonu; Metspalu, Andres; Wray, Naomi R.; Goddard, Michael E.; Yang, Jian; Visscher, Peter M. (2019). Improved polygenic prediction by Bayesian multiple regression on summary statistics. Nature Communications, 10, ARTN 5086. DOI: 10.1038/s41467-019-12653-0.
1.1.
2019
Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W.; Chasman, Daniel, I; Bentley, Amy R.; Kraja, Aldi T.; Ntalla, Ioanna; Warren, Helen R.; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K.; Brown, Michael R.; Aschard, Hugues; Feitosa, Mary F.; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan ... Morrison, Alanna C. (2019). A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Human Molecular Genetics, 28 (15), 2615−2633. DOI: 10.1093/hmg/ddz070.
1.1.
2019
Haller, Toomas; Tasa, Tõnis; Metspalu, Andres (2019). Manhattan Harvester and Cropper: a system for GWAS peak detection. BMC Bioinformatics, 20, 22−22. DOI: 10.1186/s12859-019-2600-4.
1.1.
2019
Noordam, Raymond; Bos, Maxime M.; Wang, Heming; Winkler, Thomas W.; Bentley, Amy R.; Kilpelainen, Tuomas O.; de Vries, Paul S.; Sung, Yun Ju; Schwander, Karen; Cade, Brian E.; Manning, Alisa; Aschard, Hugues; Brown, Michael R.; Chen, Han; Franceschini, Nora; Musani, Solomon K.; Richard, Melissa; Vojinovic, Dina; Aslibekyan, Stella; Bartz, Traci M. ... Redline, Susan (2019). Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nature Communications, 10, ARTN 5121. DOI: 10.1038/s41467-019-12958-0.
1.1.
2019
Thio, Chris H L; Reznichenko, Anna; van der Most, Peter J; Kamali, Zoha; Vaez, Ahmad; Smit, Johannes H; Penninx, Brenda W J H; Haller, Toomas; Mihailov, Evelin; Metspalu, Andres; Damman, Jeffrey; de Borst, Martin H; van der Harst, Pim; Verweij, Niek; Navis, Gerjan J; Gansevoort, Ron T; Nolte, Ilja M; Snieder, Harold; , (2019). Genome-Wide Association Scan of Serum Urea in European Populations Identifies Two Novel Loci. American Journal of Nephrology, 49 (3), 193−202. DOI: 10.1159/000496930.
1.1.
2019
Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Donnelly, Peter; Bates, Lesley; Barroso, Ines; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Deloukas, Panos; Duncanson, Audrey ... Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics Part B Neuropsychiatric Genetics, 180 (3), 223−231. DOI: 10.1002/ajmg.b.32716.
1.1.
2019
Timmers, Paul Rhj; Mounier, Ninon; Lall, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew D; Clark, David W; ,; Agbessi, M; Ahsan, H; Alves, I; Andiappan, A; Awadalla, P; Battle, A; Bonder, M J; Boomsma, D; Christiansen, M; Claringbould, A; Deelen, P ... Joshi, Peter K (2019). Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife, 8, e39856. DOI: 10.7554/eLife.39856.
1.1.
2019
Fest, Jesse; Vijfhuizen, Lisanne S.; Goeman, Jelle J.; Veth, Olga; Joensuu, Anni; Perola, Markus; Mannisto, Satu; Ness-Jensen, Eivind; Hveem, Kristian; Haller, Toomas; Tonisson, Neeme; Mikkel, Kairit; Metspalu, Andres; van Duijn, Cornelia M.; Ikram, Arfan; Stricker, Bruno H.; Ruiter, Rikje; van Eijck, Casper H. J.; van Ommen, Gert-Jan B.; 't Hoen, Peter A. C. (2019). Search for Early Pancreatic Cancer Blood Biomarkers in Five European Prospective Population Biobanks Using Metabolomics. Endocrinology, 160 (7), 1731−1742. DOI: 10.1210/en.2019-00165.
1.1.
2019
Kilpelainen, Tuomas O.; Bentley, Amy R.; Noordam, Raymond; Sung, Yun Ju; Schwander, Karen; Winkler, Thomas W.; Jakupovic, Hermina; Chasman, Daniel I.; Manning, Alisa; Ntalla, Ioanna; Aschard, Hugues; Brown, Michael R.; de las Fuentes, Lisa; Franceschini, Nora; Guo, Xiuqing; Vojinovic, Dina; Aslibekyan, Stella; Feitosa, Mary F.; Kho, Minjung; Musani, Solomon K. ... Loos, Ruth J. F. (2019). Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, 10, ARTN 376. DOI: 10.1038/s41467-018-08008-w.
1.1.
2019
van der Spek, Ashley; Broer, Linda; Draisma, Harmen H. M.; Pool, Rene; Albrecht, Eva; Beekman, Marian; Mangino, Massimo; Raag, Mait; Nyholt, Dale R.; Dharuri, Harish K.; Codd, Veryan; Amin, Najaf; de Geus, Eco J. C.; Deelen, Joris; Demirkan, Ayse; Yet, Idil; Fischer, Krista; Haller, Toomas; Henders, Anjali K.; Isaacs, Aaron ... Gieger, Christian (2019). Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium. Scientific Reports, 9 (1), 1162323. DOI: 10.1038/s41598-019-47282-6.
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in Medicine, 21 (5), 1−8. DOI: 10.1038/s41436-018-0311-2.
1.1.
2019
Tin, Adrienne; Marten, Jonathan; Kuhns, Victoria L. Halperin; Li, Yong; Wuttke, Matthias; Kirsten, Holger; Sieber, Karsten B.; Qiu, Chengxiang; Gorski, Mathias; Yu, Zhi; Giri, Ayush; Sveinbjornsson, Gardar; Li, Man; Chu, Audrey Y.; Hoppmann, Anselm; O'Connor, Luke J.; Prins, Bram; Nutile, Teresa; Noce, Damia; Akiyama, Masato ... Koettgen, Anna (2019). Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics, 51 (10), 1459−1478. DOI: 10.1038/s41588-019-0504-x.
1.1.
2019
Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; ,; ,; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D ... Vrieze, Scott (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51 (2), 237−248. DOI: 10.1038/s41588-018-0307-5.
1.1.
2019
Watson, Hunna J.; Yilmaz, Zeynep; Thorntont, Laura M.; Hubel, Christopher; Coleman, Jonathan R., I; Gaspar, Helena A.; Bryois, Julien; Hinney, Anke; Leppa, Virpi M.; Mattheisen, Manuel; Medland, Sarah E.; Ripke, Stephan; Yao, Shuyang; Giusti-Rodriguez, Paola; Hanscombe, Ken B.; Purves, Kirstin L.; Adan, Roger A. H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A. ... Bulik, Cynthia M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51 (8), 1207−+. DOI: 10.1038/s41588-019-0439-2.
1.1.
2019
Tasa, T,; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 442−454. DOI: 10.1038/s41431-018-0300-6.
1.1.
2019
Stahl, Eli A; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, Maciej; Byrne, Enda M; Pers, Tune H; Holmans, Peter A; Richards, Alexander L; Abbott, Liam; Agerbo, Esben ... , (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51 (5), 793−803. DOI: 10.1038/s41588-019-0397-8.
1.1.
2019
de Vries, Paul S.; Brown, Michael R.; Bentley, Amy R.; Sung, Yun J.; Winkler, Thomas W.; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T.; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E.; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Richard, Melissa A.; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C. (2019). Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology, 188 (6), 1033−1054. DOI: 10.1093/aje/kwz005.
1.1.
2019
Arnau-Soler, Aleix; Macdonald-Dunlop, Erin; Adams, Mark J.; Clarke, Toni-Kim; MacIntyre, Donald J.; Milburn, Keith; Navrady, Lauren; Hayward, Caroline; McIntosh, Andrew M.; Thomson, Pippa A.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Agerbo, Esben; Air, Tracy M.; Andlauer, Till F. M.; Bacanu, Silviu-Alin ... Sullivan, Patrick F. (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9, ARTN 14. DOI: 10.1038/s41398-018-0360-y.
1.3.
2019
Pappa, Liina; Asser, Andres; Lõokene, Cristina; Pedak, Kirsti; Poola, Merle; Nikopensius, Tiit; Metspalu, Andres; Paal, Ann (2019). Seljaajusong ja hüdrotsefaalia: üldine ülevaade ning 30 aastat registriandmete kogumist Eestis. Eesti Arst, 98 (11), 636−644.
5.1.
2019
Tõnisson, Neeme; Roht; Laura; Palover, Marili; Leitsalu, Liis; Läll, Kristi; Fischer; Kruuv-Käo, Krista; Eelma, Evelyn; Lehtsaar, Jaak; Jürgens, Hannes; Kütner, Riina; Valvere, Vahur; Nikopensius, Tiit; Reigo, Anu: Tammesoo, Mari-Liis; Esko, Tõnu; Metspalu, Andres; Padrik, Peeter (2019). Genotype first female breast cancer risk-based screening and management, initial lessons from a national pilot project. European Journal of Human Genetics, 10: European Human Genetics Conference, 15–18 juuni, 2019. Nature Research. (SUPPLEMENT).
6.7.
2019
Kals, Mart; Nikopensius, Tiit; Läll, Kristi; Pärn, Kalle; Tõnis Sikka, Timo; Suvisaari, Jaana; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Metspalu, Andres; Esko, Tõnu; Palta, Priit; Mägi, Reedik; (2019). Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses. bioRxiv, 579201. DOI: 10.1101/579201.
1.1.
2018
Tanskanen, Tomas; van den Berg, Linda; Välimäki, Niko; Aavikko, Mervi; Ness-Jensen, Eivind; Hveem, Kristian; Wettergren, Yvonne; Bexe Lindskog, Elinor; Tõnisson, Neeme; Metspalu, Andres; Silander, Kaisa; Orlando, Giulia; Law, Philip J; Tuupanen, Sari; Gylfe, Alexandra E; Hänninen, Ulrika A; Cajuso, Tatiana; Kondelin, Johanna; Sarin, Antti-Pekka; Pukkala, Eero ... Aaltonen, Lauri A (2018). Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci. International Journal of Cancer, 142 (3), 540−546. DOI: 10.1002/ijc.31076.
1.1.
2018
Zhou, Bin; Bentham, James; Di Cesare, Mariachiara; Bixby, Honor; Danaei, Goodarz; Hajifathalian, Kaveh; Taddei, Cristina; Carrillo-Larco, Rodrigo M.; Djalalinia, Shirin; Khatibzadeh, Shahab; Lugero, Charles; Peykari, Niloofar; Zhang, Wan Zhu; Bennett, James; Bilano, Ver; Stevens, Gretchen A.; Cowan, Melanie J.; Riley, Leanne M.; Chen, Zhengming; Hambleton, Ian R. ... Cisneros, Julio Zuniga (2018). Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. International Journal of Epidemiology, 47 (3), 872−893. DOI: 10.1093/ije/dyy016.
1.1.
2018
Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M.; Andlauer, Till M. F.; Bacanu, Silviu-Alin; Baekvad-Hansen, Marie; Beekman, Aartjan F. T.; Bigdeli, Tim B.; Binder, Elisabeth B.; Blackwood, Douglas R. H.; Bryois, Julien; Buttenschon, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668−684. DOI: 10.1038/s41588-018-0090-3.
1.1.
2018
Barrios, Clara; Zierer, Jonas; Würtz, Peter; Haller, Toomas; Metspalu, Andres; Gieger, Christian; Thorand, Barbara; Meisinger, Christa; Waldenberger, Melanie; Raitakari, Olli; Lehtimäki, Terho; Otero, Sol; Rodriguez, Eva; Pedro-Botet, Juan; Kähönen, Mika; Ala-Korpela, Mika; Kastenmüller, Gabi; Spector, Tim D.; Pascual, Julio; Menni, Cristina (2018). Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations. Scientific Reports, 8, ARTN 15249. DOI: 10.1038/s41598-018-33507-7.
1.1.
2018
Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166. DOI: 10.1371/journal.pone.0198166.
1.1.
2018
de Jong, Simone; Abdalla Diniz, Mateus Jose; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Curtis, Charlesg; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O'Reilly, Paul F.; Belangero, Sintia, I; Bressan, Rodrigo A.; Breen, Gerome; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M. ... Shi, Jianxin (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology, 1, ARTN 163. DOI: 10.1038/s42003-018-0155-y.
1.1.
2018
Tynkkynen J., Chouraki V., van der Lee S.J, Hernesniemi J., Yang, Q., Li, S., Beiser, A., Larson, M.G., Sääksjärvi, K., Shipley, M.,J., Singh-Manoux, A., Gerszten, R.E., Wang T.J., Havulinna A.S., Würtz P., Fischer K., Demirkan A., Ikram M.A., Amin N., Lehtimäki T, Kähönen M., Perola M., Metspalu A., Kangas A., Soininen P., Ala-Korpela M., Vasan R.S., Kivimäki M., van Duijn C.M, Seshadri S., Salomaa V. (2018). Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimer's & Dementia, 723−733. DOI: 10.1016/j.jalz.2018.01.003.
1.1.
2018
Martin, Alicia R; Karczewski, Konrad J; Kerminen, Sini; Kurki, Mitja I; Sarin, Antti-Pekka; Artomov, Mykyta; Eriksson, Johan G; Esko, Tõnu; Genovese, Giulio; Havulinna, Aki S; Kaprio, Jaakko; Konradi, Alexandra; Korányi, László; Kostareva, Anna; Männikkö, Minna; Metspalu, Andres; Perola, Markus; Prasad, Rashmi B; Raitakari, Olli; Rotar, Oxana ... Daly, Mark J (2018). Haplotype Sharing Provides Insights into Fine-Scale Population History and Disease in Finland. The American Journal of Human Genetics, 102 (5), 760−775. DOI: 10.1016/j.ajhg.2018.03.003.
1.1.
2018
Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429. DOI: 10.1038/s41588-018-0205-x.
1.1.
2018
van der Lee, Sven J.; Teunissen, Charlotte E.; Pool, Rene; Shipley, Martin J.; Teumer, Alexander; Chouraki, Vincent; van Lent, Debora Melo; Tynkkynen, Juho; Fischer, Krista; Hernesniemi, Jussi; Haller, Toomas; Singh-Manoux, Archana; Verhoeven, Aswin; Willemsen, Gonneke; de Leeuw, Francisca A.; Wagner, Holger; van Dongen, Jenny; Hertel, Johannes; Budde, Kathrin; van Dijk, Ko Willems ... van Duijn, Cornelia M. (2018). Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimer's & Dementia, 14 (6), 707−722. DOI: 10.1016/j.jalz.2017.11.012.
1.1.
2018
Tedja, Milly S; Wojciechowski, Robert; Hysi, Pirro G; Eriksson, Nicholas; Furlotte, Nicholas A; Verhoeven, Virginie J M; Iglesias, Adriana I; Meester-Smoor, Magda A; Tompson, Stuart W; Fan, Qiao; Khawaja, Anthony P; Cheng, Ching-Yu; Höhn, René; Yamashiro, Kenji; Wenocur, Adam; Grazal, Clare; Haller, Toomas; Metspalu, Andres; Wedenoja, Juho; Jonas, Jost B ... Klaver, Caroline C W (2018). Genome-wide association meta-analysis highlights light-induced signaling as a driver for refractive error. Nature Genetics, 50 (6), 834−848. DOI: 10.1038/s41588-018-0127-7.
1.1.
2018
Lu, Y.; Pouget, J. G.; Andreassen, O. A.; Djurovic, S.; Esko, T.; Hultman, C. M.; Metspalu, A.; Milani, L.; Werge, T.; Sullivan, P. F. (2018). Genetic risk scores and family history as predictors of schizophrenia in Nordic registers. Psychological Medicine, 48 (7), 1201−1208. DOI: 10.1017/S0033291717002665.
1.1.
2018
Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571. DOI: 10.1038/s41588-018-0084-1.
1.1.
2018
Zekavat, Seyedeh M; Ruotsalainen, Sanni; Handsaker, Robert E; Alver, Maris; Bloom, Jonathan; Poterba, Timothy; Seed, Cotton; Ernst, Jason; Chaffin, Mark; Engreitz, Jesse; Peloso, Gina M; Manichaikul, Ani; Yang, Chaojie; Ryan, Kathleen A; Fu, Mao; Johnson, W Craig; Tsai, Michael; Budoff, Matthew; Vasan, Ramachandran S; Cupples, L Adrienne ... , (2018). Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nature Communications, 9 (1), 2606−2606. DOI: 10.1038/s41467-018-04668-w.
1.1.
2018
Yang, Yuanhao; Zhao, Huiying; Boomsma, Dorret I.; Ligthart, Lannie; Belin, Andrea C.; Smith, George Davey; Esko, Tonu; Freilinger, Tobias M.; Hansen, Thomas Folkmann; Ikram, M. Arfan; Kallela, Mikko; Kubisch, Christian; Paraskevi, Christofidou; Strachan, David P.; Wessman, Maija; Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S.; Palta, Priit; Esko, Tonu ... (2018). Molecular genetic overlap between migraine and major depressive disorder. European Journal of Human Genetics, 26, 1202−1216. DOI: 10.1038/s41431-018-0150-2.
1.1.
2018
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina; Falcone, Guido J.; Gormley, Padhraig; Malik, Rainer; Patsopoulos, Nikolaos A.; Ripke, Stephan; Wei, Zhi; Yu, Dongmei; Lee, Phil H.; Turley, Patrick; Grenier-Boley, Benjamin; Chouraki, Vincent; Kamatani, Yoichiro; Berr, Claudine ... (2018). Analysis of shared heritability in common disorders of the brain. Science, 360 (6395). DOI: 10.1126/science.aap8757.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. The American Journal of Human Genetics, 102 (3), 375−400. DOI: 10.1016/j.ajhg.2018.01.015.
1.1.
2018
Pervjakova, N.; Kukushkina, V.; Haller, T.; Kasela, S.; Joensuu, A.; Kristiansson, K.; Annilo, T.; Perola, M.; Salomaa, V.; Jousilahti, P.; Metspalu, A.; Magi, R. (2018). Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene. Biomarkers in Medicine, 12 (5), 439−446. DOI: 10.2217/bmm-2018-0020.
1.1.
2018
Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alexander W.; Ori, Anil P. S.; Loohuis, Loes M. Olde; Domenici, Enrico; Di Florio, Arianna; Papiol, Sergi; Kalman, Janos L.; Trubetskoy, Vassily; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Albani, Diego ... Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. Cell, 173 (7), ARTN 1715.e16−1732. DOI: 10.1016/j.cell.2018.05.046.
1.1.
2018
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121. DOI: 10.1038/s41588-018-0147-3.
1.1.
2018
Zeng, Jian; de Vlaming, Ronald; Wu, Yang; Robinson, Matthew R; Lloyd-Jones, Luke R; Yengo, Loic; Yap, Chloe X; Xue, Angli; Sidorenko, Julia; McRae, Allan F; Powell, Joseph E; Montgomery, Grant W; Metspalu, Andres; Esko, Tonu; Gibson, Greg; Wray, Naomi R; Visscher, Peter M; Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Nature Genetics, 50 (5), 746−753. DOI: 10.1038/s41588-018-0101-4.
1.1.
2018
Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516. DOI: 10.1038/s41588-018-0241-6.
1.1.
2018
Rimfeld, Kaili; Krapohl, Eva; Trzaskowski, Maciej; Coleman, Jonathan R I; Selzam, Saskia; Dale, Philip S; Esko, Tonu; Metspalu, Andres; Plomin, Robert (2018). Genetic influence on social outcomes during and after the Soviet era in Estonia. Nature Human Behaviour, 2 (4), 269−275. DOI: 10.1038/s41562-018-0332-5.
1.1.
2018
Tambets, Kristiina; Yunusbayev, Bayazit; Hudjashov, Georgi; Ilumäe, Anne-Mai; Rootsi, Siiri; Honkola, Terhi; Vesakoski, Outi; Atkinson, Quentin; Skoglund, Pontus; Kushniarevich, Alena; Litvinov, Sergey; Reidla, Maere; Metspalu, Ene; Saag, Lehti; Rantanen, Timo; Karmin, Monika; Parik, Jüri; Zhadanov, Sergey I; Gubina, Marina; Damba, Larisa D ... Metspalu, Mait (2018). Genes reveal traces of common recent demographic history for most of the Uralic-speaking populations. Genome Biology, 19 (1), 139−139. DOI: 10.1186/s13059-018-1522-1.
5.1.
2018
Zeng, Jian; de Vlaming, Ronald; Wu, Yang; Robinson, Matthew R.; Lloyd-Jones, Luke R.; Yengo, Loic; Yap, Chloe X.; Xue, Angli; Sidorenko, Julia; Mcrae, Allan F.; Powell, Joseph E.; Montgomery, Grant W.; Metspalu, Andres; Esko, Tonu; Gibson, Greg; Wray, Naomi R.; Visscher, Peter M.; Yang, Jian (2018). Signatures of negative selection in the genetic architecture of human complex traits. Behavior Genetics, 48 (6), 525−525.
5.1.
2018
Warren, H. R.; Evangelou, E.; Mosen, D.; Mifsud, B.; Pazoki, R.; Gao, H.; Ntritsos, G.; Dimou, N.; Evangelou, M.; Hellwege, J.; Giri, A.; Esko, T.; Metspalu, A.; Tzoulaki, I.; Barnes, M. R.; Wain, L. V.; Elliott, P.; Caulfield, M. J. (2018). GENETIC ANALYSIS OF OVER ONE MILLION PEOPLE IDENTIFIES 535 NOVEL LOCI ASSOCIATED WITH BLOOD PRESSURE AND RISK OF CARDIOVASCULAR DISEASE. Journal of Hypertension, 36, E229−E229.
6.8.
2018
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael ... Caulfield, Mark J (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (12), 1755−1755. DOI: 10.1038/s41588-018-0297-3.
6.8.
2018
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez ... McCarthy, Mark I (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5, 180002−180002. DOI: 10.1038/sdata.2018.2.
1.1.
2017
Ezzati, M; Bentham, J; Di Cesare, M; Bilano, V; Bixby, H; Zhou, B; Stevens, G.A; Riley, L.M Taddei, C; Hajifathalian, K ... NCD-RisC Group (NCD-RisC incl. Veidebaum, T) (2017). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. The Lancet, 390 (10113), 2627−2642. DOI: 10.1016/S0140-6736(17)32129-3.
1.1.
2017
Duncan, Laramie; Yilmaz, Zeynep; Gaspar, Helena; Walters, Raymond; Goldstein, Jackie; Anttila, Verneri; Bulik-Sullivan, Brendan; Ripke, Stephan; Thornton, Laura; Daly, Mark; Sullivan, Patrick F.; Zeggini, Eleftheria; Breen, Gerome; Bulik, Cynthia M.; Adan, Roger; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole; Aschauer, Harald; Baker, Jessica ... Bulik, Cynthia M. (2017). Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. American Journal of Psychiatry, 174 (9), 850−858. DOI: 10.1176/appi.ajp.2017.16121402.
1.1.
2017
Lukowski, Samuel W.; Lloyd-Jones, Luke R.; Holloway, Alexander; Kirsten, Holger; Hemani, Gibran; Yang, Jian; Small, Kerrin; Zhao, Jing; Metspalu, Andres; Dermitzakis, Emmanouil T.; Gibson, Greg; Spector, Timothy D.; Thiery, Joachim; Scholz, Markus; Montgomery, Grant W.; Esko, Tonu; Visscher, Peter M.; Powell, Joseph E. (2017). Genetic correlations reveal the shared genetic architecture of transcription in human peripheral blood. Nature Communications, 8, ARTN 483. DOI: 10.1038/s41467-017-00473-z.
1.1.
2017
Gorski, Mathias; Van der Most, Peter J.; Teumer, Alexander; Chu, Audrey Y.; Li, Man; Mijatovic, Vladan; Nolte, Ilja M.; Cocca, Massimiliano; Taliun, Daniel; Gomez, Felicia; Li, Yong; Tayo, Bamidele; Tin, Adrienne; Feitosa, Mary F.; Aspelund, Thor; Attia, John; Biffar, Reiner; Bochud, Murielle; Boerwinkle, Eric; Borecki, Ingrid ... Fuchsberger, Christian (2017). 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Scientific Reports, 7, ARTN 45040. DOI: 10.1038/srep45040.
1.1.
2017
Tropf, Felix C.; Lee, S. Hong; Verweij, Renske M.; Stulp, Gert; van der Most, Peter J.; de Vlaming, Ronald; Bakshi, Andrew; Briley, Daniel A.; Rahal, Charles; Hellpap, Robert; Iliadou, Anastasia N.; Esko, Tonu; Metspalu, Andres; Medland, Sarah E.; Martin, Nicholas G.; Barban, Nicola; Snieder, Harold; Robinson, Matthew R.; Mills, Melinda C. (2017). Hidden heritability due to heterogeneity across seven populations. Nature Human Behaviour, 1 (10), 757−765. DOI: 10.1038/s41562-017-0195-1.
1.1.
2017
Lloyd-Jones, Luke R.; Holloway, Alexander; McRae, Allan; Yang, Jian; Small, Kerrin; Zhao, Jing; Zeng, Biao; Bakshi, Andrew; Metspalu, Andres; Dermitzakis, Manolis; Gibson, Greg; Spector, Tim; Montgomery, Grant; Esko, Tonu; Visscher, Peter M.; Powell, Joseph E. (2017). The Genetic Architecture of Gene Expression in Peripheral Blood. The American Journal of Human Genetics, 100 (2), 228−237. DOI: 10.1016/j.ajhg.2016.12.008.
1.1.
2017
Marshall, Christian R.; Marshall, Christian R.; Howrigan, Daniel P.; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S.; Antaki, Danny; Shetty, Aniket; Holmans, Peter A.; Pinto, Dalila; Gujral, Madhusudan; Brandler, William M.; Malhotra, Dheeraj; Wang, Zhouzhi; Fajarado, Karin V. Fuentes; Maile, Michelle S.; Ripke, Stephan; Agartz, Ingrid; Albus, Margot ... Sebat, Jonathan (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics, 1, 27−35. DOI: 10.1038/ng.3725.
1.1.
2017
Haller, Toomas; Leitsalu, Liis; Fischer, Krista; Nuotio, Marja-Liisa; Esko, Tonu; Boomsma, Dorothea Irene; Kyvik, Kirsten Ohm; Spector, Tim D.; Perola, Markus; Metspalu, Andres (2017). MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies. PLoS ONE, 12 (1), ARTN e0170325. DOI: 10.1371/journal.pone.0170325.
1.1.
2017
Marouli, Eirini; Graff, Mariaelisa; Medina-Gomez, Carolina; Lo, Ken Sin; Wood, Andrew R.; Kjaer, Troels R.; Fine, Rebecca S.; Lu, Yingchang; Schurmann, Claudia; Highland, Heather M.; Rueger, Sina; Thorleifsson, Gudmar; Justice, Anne E.; Lamparter, David; Stirrups, Kathleen E.; Turcot, Valerie; Young, Kristin L.; Winkler, Thomas W.; Esko, Tonu; Karaderi, Tugce ... Lettre, Guillaume (2017). Rare and low-frequency coding variants alter human adult height. Nature, 7640, 186−190. DOI: 10.1038/nature21039.
1.1.
2017
Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845. DOI: 10.1038/ng.3841.
1.1.
2017
Kasela, Silva; Kisand, Kai; Tserel, Liina; Kaleviste, Epp; Remm, Anu; Fischer, Krista; Esko, Tõnu; Westra, Harm-Jan; Fairfax, Benjamin P; Makino, Seiko; Knight, Julian C; Franke, Lude; Metspalu, Andres; Peterson, Pärt; Milani, Lili (2017). Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells. PLoS Genetics, 13 (3, 3), ARTN e1006643. DOI: 10.1371/journal.pgen.1006643.
1.1.
2017
Li, Man; Li, Yong; Weeks, Olivia; Mijatovic, Vladan; Teumer, Alexander; Huffman, Jennifer E.; Tromp, Gerard; Fuchsberger, Christian; Gorski, Mathias; Lyytikainen, Leo-Pekka; Nutile, Teresa; Sedaghat, Sanaz; Sorice, Rossella; Tin, Adrienne; Yang, Qiong; Ahluwalia, Tarunveer S.; Arking, Dan E.; Bihlmeyer, Nathan A.; Boeger, Carsten A.; Carroll, Robert J. ... Chu, Audrey Y. (2017). SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. Journal of the American Society of Nephrology, 3, 981−994. DOI: 10.1681/ASN.2016020131.
1.1.
2017
Mihailov, E.; Nikopensius, T.; Reigo, A.; Nikkolo, C.; Kals, M.; Aruaas, K.; Milani, L.; Seepter, H.; Metspalu, A. (2017). Whole-exome sequencing identifies a potential TTN mutation in a multiplex family with inguinal hernia. Hernia, 21 (1), 95−100. DOI: 10.1007/s10029-016-1491-9.
1.1.
2017
Pappa, Liina; Kals, Mart; Kivistik, Paula Ann; Metspalu, Andres; Paal, Ann; Nikopensius, Tiit (2017). Exome analysis in an Estonian multiplex family with neural tube defects—a case report. Child's Nervous System, 33 (9), 1575−1581. DOI: 10.1007/s00381-017-3491-1.
1.1.
2017
Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia; Gaulton, Kyle J.; Kaakinen, Marika; Pervjakova, Natalia; Pers, Tune H.; Johnson, Andrew D.; Eicher, John D.; Jackson, Anne U.; Ferreira, Teresa; Lee, Yeji; Ma, Clement; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Van Zuydam, Natalie R.; Mahajan, Anubha; Chen, Han ... Prokopenko, Inga (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes, 66 (11), 2888−2902. DOI: 10.2337/db16-1253.
1.1.
2017
Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, Tasa T, Metspalu A, Milani L, Peterson P. (2017). DNA breaks and chromatin structural changes enhance the transcription of Autoimmune Regulator target genes. Journal of Biological Chemistry, 292 (16), 6542−6554. DOI: 10.1074/jbc.M116.764704.
1.1.
2017
Zeng, Biao; Lloyd-Jones, Luke R.; Holloway, Alexander; Marigorta, Urko M.; Metspalu, Andres; Montgomery, Grant W.; Esko, Tonu; Brigham, Kenneth L.; Quyyumi, Arshed A.; Idaghdour, Youssef; Yang, Jian; Visscher, Peter M.; Powell, Joseph E.; Gibson, Greg (2017). Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression. G3 Genes|Genome|Genetics, 7 (8), 2532−2544. DOI: 10.1534/g3.117.043752.
1.1.
2017
Webb, Thomas R.; Erdmann, Jeanette; Stirrups, Kathleen E.; Stitziel, Nathan O.; Masca, Nicholas G. D.; Jansen, Henning; Kanoni, Stavroula; Nelson, Christopher P.; Ferrario, Paola G.; Koenig, Inke R.; Eicher, John D.; Johnson, Andrew D.; Hamby, Stephen E.; Betsholtz, Christer; Ruusalepp, Arno; Franzen, Oscar; Schadt, Eric E.; Bjoerkegren, Johan L. M.; Weeke, Peter E.; Auer, Paul L. ... Kathiresan, Sekar (2017). Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology, 7, 823−836. DOI: 10.1016/j.jacc.2016.11.056.
1.1.
2017
Linner, R. Karlsson; Marioni, R. E.; Rietveld, C. A.; Simpkin, A. J.; Davies, N. M.; Watanabe, K.; Armstrong, N. J.; Auro, K.; Baumbach, C.; Bonder, M. J.; Buchwald, J.; Fiorito, G.; Ismail, K.; Iurato, S.; Joensuu, A.; Karell, P.; Kasela, S.; Lahti, J.; Mcrae, A. F.; Mandaviya, P. R. ... Benjamin, D. J. (2017). An epigenome-wide association study meta-analysis of educational attainment. Molecular Psychiatry, 22 (12), 1680−1690. DOI: 10.1038/mp.2017.210.
1.1.
2017
Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung ... Lindgren, Cecilia M. (2017). A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 66 (7), 2019−2032. DOI: 10.2337/db16-1329.
1.1.
2017
Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D. ... Kilpelainen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults. PLoS Genetics, 13 (4), ARTN e1006528. DOI: 10.1371/journal.pgen.1006528.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences, 114 (3), E327−E336. DOI: 10.1073/pnas.1619052114.
1.1.
2017
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stančáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179. DOI: 10.1038/sdata.2017.179.
1.1.
2017
Schormair, Barbara; Zhao, Chen; Bell, Steven; Tilch, Erik; Salminen, Aaro V; Pütz, Benno; Dauvilliers, Yves; Stefani, Ambra; Högl, Birgit; Poewe, Werner; Kemlink, David; Sonka, Karel; Bachmann, Cornelius G; Paulus, Walter; Trenkwalder, Claudia; Oertel, Wolfgang H; Hornyak, Magdolna; Teder-Laving, Maris; Metspalu, Andres; Hadjigeorgiou, Georgios M ... Wilson, Catherine H (2017). Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. The Lancet Neurology, 16 (11), 898−907. DOI: 10.1016/S1474-4422(17)30327-7.
1.1.
2017
Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186. DOI: 10.1038/ng.3912.
1.1.
2017
Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark D.W., Nutile T., Barnes C.L.K., Timmers P.R.H.J., Shen X., Gandin I., McDaid A.F., Hansen T.F., Gordon S.D., Giulianini F., Boutin T.S., Abdellaoui A., Zhao W., Medina-Gomez C., Bartz T.M., Trompet S., Lange L.A., Raffield L., van der Spek A.,/.../,Bertram L., Pendleton N., Kardia S.L.R., Ciullo M., Becker D.M., Wong A., Psaty B.M., van Duijn C.M., Wilson J.G., Jukema J.W., Kiemeney L., Uitterlinden A.G, Franceschini N., North K.E., Weir D.R., Metspalu A., Boomsma D.I., Hayward C., Chasman D., Martin N.G., Sattar N., Campbell H., Esko T., Kutalik Z., Wilson J.F. (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, 910. DOI: 10.1038/s41467-017-00934-5.
1.1.
2017
Mitt, Mario; Kals, Mart; Parn, Kalle; Gabriel, Stacey B; Lander, Eric S; Palotie, Aarno; Ripatti, Samuli; Morris, Andrew P; Metspalu, Andres; Esko, Tonu; Magi, Reedik; Palta, Priit; (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. European Journal of Human Genetics, 25 (7), 869−879. DOI: 10.1038/ejhg.2017.51.
1.1.
2017
Nath, Artika P.; Ritchie, Scott C.; Byars, Sean G.; Fearnley, Liam G.; Havulinna, Aki S.; Joensuu, Anni; Kangas, Antti J.; Soininen, Pasi; Wennerstrom, Annika; Milani, Lili; Metspalu, Andres; Mannisto, Satu; Wurtz, Peter; Kettunen, Johannes; Raitoharju, Emma; Kahonen, Mika; Juonala, Markus; Palotie, Aarno; Ala-Korpela, Mika; Ripatti, Samuli ... Inouye, Michael (2017). An interaction map of circulating metabolites, immune gene networks, and their genetic regulation. Genome Biology, 18, ARTN 146. DOI: 10.1186/s13059-017-1279-y.
1.1.
2017
Wain, Louise V.; Vaez, Ahmad; Jansen, Rick; Joehanes, Roby; van der Most, Peter J.; Erzurumluoglu, A. Mesut; O'Reilly, Paul F.; Cabrera, Claudia P.; Warren, Helen R.; Rose, Lynda M.; Verwoert, Germaine C.; Hottenga, Jouke-Jan; Strawbridge, Rona J.; Esko, Tõnu; Arking, Dan E.; Hwang, Shih-Jen; Guo, Xiuqing; Kutalik, Zoltan; Trompet, Stella; Shrine, Nick ... Xiao, Limin (2017). Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney. Hypertension, 70 (3), e4−e19. DOI: 10.1161/HYPERTENSIONAHA.117.09438.
1.1.
2017
Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish; Emdin, Connor; Alam, Dewan; Alves, Alexessander Couto; Amouyel, Philippe; Di Angelantonio, Emanuele; Arveiler, Dominique; Assimes, Themistocles L.; Auer, Paul L.; Baber, Usman; Ballantyne, Christie M.; Bang, Lia E.; Benn, Marianne; Bis, Joshua C. ... Kathiresan, Sekar (2017). Exome-wide association study of plasma lipids in > 300,000 individuals. Nature Genetics, 49 (12), 1758−1772. DOI: 10.1038/ng.3977.
1.1.
2017
Allebrandt, Karla V.; Teder-Laving, Maris; Cusumano, Paola; Frishman, Goar; Levandovski, Rosa; Ruepp, Andreas; Hidalgo, Maria P. L.; Costa, Rodolfo; Metspalu, Andres; Roenneberg, Till; De Pitta, Cristiano (2017). Identifying pathways modulating sleep duration: from genomics to transcriptomics. Scientific Reports, 7 (4555), 1−11. DOI: 10.1038/s41598-017-04027-7.
1.1.
2017
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201. DOI: 10.1038/mp.2016.71.
1.1.
2017
Huan, Tianxiao; Joehanes, Roby; Schurmann, Claudia; Schramm, Katharina; Pilling, Luke C; Peters, Marjolein J; Mägi, Reedik; DeMeo, Dawn; O'Connor, George T; Ferrucci, Luigi; Teumer, Alexander; Homuth, Georg; Biffar, Reiner; Völker, Uwe; Herder, Christian; Waldenberger, Melanie; Peters, Annette; Zeilinger, Sonja; Metspalu, Andres; Hofman, Albert ... Levy, Daniel (2017). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics, 25 (21), 1−33. DOI: 10.1093/hmg/ddw288.
1.1.
2017
R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical Pharmacology & Therapeutics, 101 (5), 684−695. DOI: 10.1002/cpt.540.
1.1.
2017
Pallister, Tess; Haller, Toomas; Thorand, Barbara; Altmaier, Elisabeth; Cassidy, Aedin; Martin, Tiphaine; Jennings, Amy; Mohney, Robert P; Gieger, Christian; MacGregor, Alexander; Kastenmüller, Gabi; Metspalu, Andres; Spector, Tim D; Menni, Cristina (2017). Metabolites of milk intake: a metabolomic approach in UK twins with findings replicated in two European cohorts. European Journal of Nutrition, 56 (7), 2379−2391. DOI: 10.1007/s00394-016-1278-x.
1.1.
2017
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N. William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez ... McCarthy, Mark I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, ARTN 170179. DOI: 10.1038/sdata.2017.179.
1.1.
2017
Tsoi, Lam C.; Stuart, Philip E.; Tian, Chao; Gudjonsson, Johann E.; Das, Sayantan; Zawistowski, Matthew; Ellinghaus, Eva; Barker, Jonathan N.; Chandran, Vinod; Dand, Nick; Duffin, Kristina Callis; Enerback, Charlotta; Esko, Tonu; Franke, Andre; Gladman, Dafna D.; Hoffmann, Per; Kingo, Kulli; Koks, Sulev; Krueger, Gerald G.; Lim, Henry W. ... Elder, James T. (2017). Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nature Communications, 8, ARTN 15382. DOI: 10.1038/ncomms15382.
1.1.
2017
Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genetics, 13 (6), e1006812. DOI: 10.1371/journal.pgen.1006812.
1.1.
2017
Haller-Kikkatalo, Kadri; Alnek, Kristi; Metspalu, Andres; Mihailov, Evelin; Metsküla, Kaja; Kisand, Kalle; Pisarev, Heti; Salumets, Andres; Uibo, Raivo (2017). Demographic associations for autoantibodies in disease-free individuals of a European population. Scientific Reports, 7, 44846−44846. DOI: 10.1038/srep44846.
1.1.
2017
Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltan; Xue, Luting; Mahajan, Anubha ... Cupples, L. Adrienne (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (14977), ARTN 14977. DOI: 10.1038/ncomms14977.
1.1.
2017
Urgard, Egon; Reigo, Anu; Reinmaa, Eva; Rebane, Ana; Metspalu, Andres (2017). Human basonuclin 2 up-regulates a cascade set of interferon-stimulated genes with anti-cancerous properties in a lung cancer model. Cancer Cell international, 17, 18−18. DOI: 10.1186/s12935-017-0394-x.
1.1.
2017
Direk, Nese; Williams, Stephanie; Smith, Jennifer A.; Ripke, Stephan; Air, Tracy; Amare, Azmeraw T.; Amin, Najaf; Baune, Bernhard T.; Bennett, David A.; Blackwood, Douglas H. R.; Boomsma, Dorret; Breen, Gerome; Buttenschon, Henriette N.; Byrne, Enda M.; Borglum, Anders D.; Castelao, Enrique; Cichon, Sven; Clarke, Toni-Kim; Cornelis, Marilyn C.; Dannlowski, Udo ... Sullivan, Patrick F. (2017). An Analysis of Two Genome-wide Association Meta-analyses Identifies a New Locus for Broad Depression Phenotype. Biological Psychiatry, 82 (5), 322−329. DOI: 10.1016/j.biopsych.2016.11.013.
1.1.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 49 (3), 403−415. DOI: 10.1038/ng.3768.
1.2.
2017
Auffray, C; Sagner, M; Abdelhak, S; Adcock, I; Agusti, A; Amaral, M; Antonarakis, S; Arena, R; Argoul, F; Balling, R; Barabasi, A-L; Beckmann, J; Bjartell, A; Blomberg, N; Bourgeron, T; Boutron, B; Brahmachari, S; Bréchot, C; Brightling, C; Cascante, M ... Nobrega, F. (2017). Viva Europa, a Land of Excellence in Research and Innovation for Health and Wellbeing. Progress in Preventive Medicine, 2 (3), e006. DOI: 10.1097/pp9.0000000000000006.
5.1.
2017
Taba, Nele; Fischer, Krista; Esko, Tonu; Metspalu, Andres; Pirastu, Nicola (2017). Investigating Causal Relationships Between Dietary Items and Blood Metabolites Using 2-Sample Mendelian Randomization. Human Heredity, 83 (5), 244−245.
5.1.
2017
Taba, Nele; Esko, Tonu; Metspalu, Andres; Fischer, Krista (2017). Empirically Derived Dietary Patterns - Characteristics, Phenotypic Background, and Associations with NMR Metabolites and Health Outcomes in the Estonian Biobank Cohort. Human Heredity, 83 (1), 24−24.
5.2.
2017
Tamm, Madli; Oselin, Kersti; Kivistik, Paula Ann; Kals, Mart; Lokk, Kaie; Keerma, Katrin; Saare, Margot; Roosipuu, Retlav; Leismann, Tiina; Roomere, Hanno; Metspalu, Andres; Tõnisson, Neeme (2017). Monitoring cancer related mutations in cell-free DNA of lung cancer patients. European Journal of Human Genetics: European Human Genetics Conference, Copenhagen, Denmark, May 27–30, 2017. Nature Publishing Group.
5.2.
2017
Palover, M; Leitsalu, L; Nikopensius, T; Vaiküll, K; Kals, M; Padrik, P; Esko, T; Metspalu, A; Tõnisson, N. (2017). High-risk genetic variants predisposing for breast, ovarian and prostate cancer among Estonian gene donors. European Journal of Human Genetics: European Human Genetics Conference, Copenhagen, Denmark, May 27–30, 2017. Nature Publishing Group.
6.8.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Elliott, Paul (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (vol 49, pg 403, 2017). Nature Genetics, 49 (10), 1558−1558. DOI: 10.1038/ng1017-1558a.
6.8.
2017
Gorski, Mathias; van der Most, Peter J.; Teumer, Alexander; Chu, Audrey Y.; Li, Man; Mijatovic, Vladan; Nolte, Ilja M.; Cocca, Massimiliano; Taliun, Daniel; Gomez, Felicia; Li, Yong; Tayo, Bamidele; Tin, Adrienne; Feitosa, Mary F.; Aspelund, Thor; Attia, John; Biffar, Reiner; Bochud, Murielle; Boerwinkle, Eric; Borecki, Ingrid ... Fuchsberger, Christian (2017). 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function (vol 7, 45040, 2017). Scientific Reports, 7 (45040), ARTN 46835. DOI: 10.1038/srep46835.
6.8.
2017
Lokk, Kaie; Vooder, Tõnu; Kolde, Raivo; Välk, Kristjan; Võsa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tõnisson, Neeme (2017). Correction: Methylation Markers of Early-Stage Non-Small Cell Lung Cancer. PLoS ONE, 12 (1), e0170833−e0170833. DOI: 10.1371/journal.pone.0170833.
6.8.
2017
Lokk, Kaie; Vooder, Tonu; Kolde, Raivo; Valk, Kristjan; Vosa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tonisson, Neeme (2017). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer (vol 7, e39813, 2012). PLoS ONE, 1, ARTN e0170833. DOI: 10.1371/journal.pone.0170833.
6.8.
2017
Lloyd-Jones, Luke R.; Holloway, Alexander; McRae, Allan; Yang, Jian; Small, Kerrin; Zhao, Jing; Zeng, Biao; Bakshi, Andrew; Metspalu, Andres; Dermitzakis, Manolis; Gibson, Greg; Spector, Tim; Montgomery, Grant; Esko, Tonu; Visscher, Peter M.; Powell, Joseph E. (2017). The Genetic Architecture of Gene Expression in Peripheral Blood (vol 100, pg 228, 2017). The American Journal of Human Genetics, 2, 371−371. DOI: 10.1016/j.ajhg.2017.01.026.
1.1.
2016
Pajusalu, S.; Talvik, I.; Noormets, K.; Talvik, T.; Põder, H.; Joost, K.; Puusepp, S.; Piirsoo, A.; Stenzel, W.; Goebel, HH.; Nikopensius, T.; Annilo, T.; Nõukas, M.; Metspalu, A.; Õunap, K.; Reimand, T. (2016). De novo exonic mutation in MYH7 gene leading to exon skipping in a patient with early onset muscular weakness and fiber-type disproportion. Neuromuscular Disorders, 26 (3), 236−239. DOI: 10.1016/j.nmd.2015.11.011.
1.1.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8), 856−866. DOI: 10.1038/ng.3598.
1.1.
2016
Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement; Fontanillas, Pierre; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M ... McCarthy, Mark I (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41−47. DOI: 10.1038/nature18642.
1.1.
2016
Jones, Samuel E; Tyrrell, Jessica; Wood, Andrew R; Beaumont, Robin N; Ruth, Katherine S; Tuke, Marcus A; Yaghootkar, Hanieh; Hu, Youna; Teder-Laving, Maris; Hayward, Caroline; Roenneberg, Till; Wilson, James F; Del Greco, Fabiola; Hicks, Andrew A; Shin, Chol; Yun, Chang-Ho; Lee, Seung Ku; Metspalu, Andres; Byrne, Enda M; Gehrman, Philip R ... Weedon, Michael N (2016). Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci. PLoS Genetics, 12 (8), e1006125−e1006125. DOI: 10.1371/journal.pgen.1006125.
1.1.
2016
Cáceres, Alejandro; Esko, Tõnu; Pappa, Irene; Gutiérrez, Armand; Lopez-Espinosa, Maria-Jose; Llop, Sabrina; Bustamante, Mariona; Tiemeier, Henning; Metspalu, Andres; Joshi, Peter K; Wilsonx, James F; Reina-Castillón, Judith; Shin, Jean; Pausova, Zdenka; Paus, Tomáš; Sunyer, Jordi; Pérez-Jurado, Luis A; González, Juan R (2016). Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence. PLoS ONE, 11 (6), e0157739−e0157739. DOI: 10.1371/journal.pone.0157739.
1.1.
2016
Luyten, Walter; Antal, Peter; Braeckman, Bart P; Bundy, Jake; Cirulli, Francesca; Fang-Yen, Christopher; Fuellen, Georg; Leroi, Armand; Liu, Qingfei; Martorell, Patricia; Metspalu, Andres; Perola, Markus; Ristow, Michael; Saul, Nadine; Schoofs, Liliane; Siems, Karsten; Temmerman, Liesbet; Smets, Tina; Wolk, Alicja; Rattan, Suresh I S (2016). Ageing with elegans: a research proposal to map healthspan pathways. Biogerontology, 17 (4), 771−782.
1.1.
2016
Tajuddin, Salman M; Schick, Ursula M; Eicher, John D; Chami, Nathalie; Giri, Ayush; Brody, Jennifer A; Hill, W David; Kacprowski, Tim; Li, Jin; Lyytikäinen, Leo-Pekka; Manichaikul, Ani; Mihailov, Evelin; O'Donoghue, Michelle L; Pankratz, Nathan; Pazoki, Raha; Polfus, Linda M; Smith, Albert Vernon; Schurmann, Claudia; Vacchi-Suzzi, Caterina; Waterworth, Dawn M ... Auer, Paul L (2016). Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. The American Journal of Human Genetics, 99 (1), 22−39. DOI: 10.1016/j.ajhg.2016.05.003.
1.1.
2016
Eicher, John D; Chami, Nathalie; Kacprowski, Tim; Nomura, Akihiro; Chen, Ming-Huei; Yanek, Lisa R; Tajuddin, Salman M; Schick, Ursula M; Slater, Andrew J; Pankratz, Nathan; Polfus, Linda; Schurmann, Claudia; Giri, Ayush; Brody, Jennifer A; Lange, Leslie A; Manichaikul, Ani; Hill, W David; Pazoki, Raha; Elliot, Paul; Evangelou, Evangelos ... Johnson, Andrew D (2016). Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. The American Journal of Human Genetics, 99 (1), 40−55. DOI: 10.1016/j.ajhg.2016.05.005.
1.1.
2016
Pagani, Luca; Lawson, Daniel John; Jagoda, Evelyn; Moerseburg, Alexander; Eriksson, Anders; Mitt, Mario; Clemente, Florian; Hudjashov, Georgi; DeGiorgio, Michael; Saag, Lauri; Wall, Jeffrey D.; Cardona, Alexia; Mägi, Reedik; Sayres, Melissa A. Wilson; Kaewert, Sarah; Inchley, Charlotte; Scheib, Christiana L.; Järve, Mari; Karmin, Monika; Jacobs, Guy S. ... Metspalu, Mait (2016). Genomic analyses inform on migration events during the peopling of Eurasia. Nature, 538 (7624), 238−257. DOI: 10.1038/nature19792.
1.1.
2016
van den Berg, Stéphanie M; de Moor, Marleen H M; Verweij, Karin J H; Krueger, Robert F; Luciano, Michelle; Arias Vasquez, Alejandro; Matteson, Lindsay K; Derringer, Jaime; Esko, Tõnu; Amin, Najaf; Gordon, Scott D; Hansell, Narelle K; Hart, Amy B; Seppälä, Ilkka; Huffman, Jennifer E; Konte, Bettina; Lahti, Jari; Lee, Minyoung; Miller, Mike; Nutile, Teresa ... Boomsma, Dorret I (2016). Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behavior Genetics, 46 (2), 170−182. DOI: 10.1007/s10519-015-9735-5.
1.1.
2016
Maillard, A M; Hippolyte, L; Rodriguez-Herreros, B; Chawner, S J R A; Dremmel, D; Agüera, Z; Fagundo, A B; Pain, A; Martin-Brevet, S; Hilbert, A; Kurz, S; Etienne, R; Draganski, B; Jimenez-Murcia, S; Männik, K; Metspalu, A; Reigo, A; Isidor, B; Le Caignec, C; David, A ... Jacquemont, S (2016). 16p11.2 Locus modulates response to satiety before the onset of obesity. International Journal of Obesity, 40 (5), 870−876. DOI: 10.1038/ijo.2015.247.
1.1.