Ann Tiiman

https://www.etis.ee/CV/Ann_Tiiman/est
3.10.1984
6204412
tiimanann@gmail.com
Neiupõlvenimi: Karafin

Teenistuskäik

Töökohad ja ametid
01.02.2010–31.08.2010   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, spetsialist (1,00)
2006–2008   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Genoomika ja proteoomika õppetool, Spetsialist (0,50)
 
 
Haridustee
2009–2012   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, doktorant
2007–2009   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, geenitehnoloogia eriala, magistri kraad
2003–2007   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, geenitehnoloogia eriala, bakalaureuse kraad
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2007−...   
Eesti Biokeemia Seltsi liige

Kvalifikatsioon

Teaduskraadid
Ann Tiiman, doktorikraad, 2012, (juh) Peep Palumaa; Vello Tõugu, Interactions of Alzheimer’s amyloid-beta peptides with Zn(II) and Cu(II) ions (Alzheimeri amüloid-beta peptiidide interaktsioonid Zn(II) ja Cu(II) ioonidega), Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut.
Ann Tiiman, magistrikraad, 2009, (juh) Vello Tõugu; Peep Palumaa, Zn(II) and Cu(II) induced aggregation and fibrillation of Alzheimer’s amyloid-beta peptide (Alzheimeri amüloidse peptiidi fibrillatsioon ja agregatsioon Zn(II) ja Cu(II) toimel), Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut.
 
 
Teaduspreemiad ja tunnustused
2012, Ann Tiiman, Eesti üliõpilaste teadustööde riiklik konkurss, I koht
2011, Ann Tiiman, Tiina Mõisa nimeline stipendium
2010, Ann Tiiman, Eesti Biokeemia Seltsi üliõpilaste teadustööde konkurss, I koht
2010, Ann Tiiman, World Federation of Scientists stipendium
2009, Ann Tiiman, Eesti üliõpilaste teadustööde riiklik konkurss, III koht
2009, Ann Tiiman, Eesti Teaduste Akadeemia üliõpilastööde konkursi II preemia
2008, Ann Tiiman, Eesti Biokeemia Seltsi üliõpilaste teadustööde konkurss, I koht
2007, Ann Tiiman, Eesti üliõpilaste teadustööde riiklik konkurss, III koht
 
 
Teadustöö põhisuunad
VALDKOND: 4. Loodusteadused ja tehnika; 4.16. Biotehnoloogia (loodusteadused ja tehnika)

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2013
Wärmlander, Sebastian; Tiiman, Ann; Abelein, Axel; Luo, Jinghui; Jarvet, Jüri; Söderberg, Kajsa L; Danielsson, Jens; Gräslund, Astrid. (2013). Biophysical Studies of the Amyloid beta-Peptide: Interactions with Metal Ions and Small Molecules. Chembiochem : a European journal of chemical biology, 14 (14), 1692−1704.
1.1.
2013
Tiiman, Ann; Noormägi, Andra; Friedemann, Merlin; Krishtal, Jekaterina; Palumaa, Peep; Tõugu, Vello (2013). Effect of agitation on the peptide fibrillization: Alzheimer’s amyloid- b peptide 1-42 but not amylin and insulin fibrils can grow under quiescent conditions. Journal of Peptide Science, 19, 386−391.
1.1.
2013
Tiiman, Ann; Palumaa, Peep; Tõugu, Vello (2013). The Missing Link in the Amyloid Cascade of Alzheimer's Disease - Metal Ions. Neurochemistry International, 62 (4), 367−378.
5.2.
2012
Tiiman, Ann; Tõugu, Vello; Palumaa, Peep (2012). Interactions of Alzheimer’s Amyloid-beta Peptides with Zn(II) and Cu(II) Ions. In: .3rd Scandinavian Meeting on Amyloid Proteins and Disease, Sigtuna, Sweden, October 25-27 2012.
1.1.
2011
Tõugu, Vello; Tiiman, Ann; Palumaa, Peep (2011). Interactions of Zn(II) and Cu(II) ions with Alzheimer’s amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity. Metallomics, 3, 250−261.10.1039/c0mt00073f.
1.1.
2010
Zovo, Kairit; Helk, Eneken; Karafin, Ann; Tõugu, Vello; Palumaa, Peep (2010). Label-Free High-Throughput Screening Assay for Inhibitors of Alzheimer’s Amyloid-β Peptide Aggregation Based on MALDI MS. Analytical Chemistry, 82 (20), 8558−8565.10.1021/ac101583q.
1.1.
2009
Tõugu, V.; Karafin, A.; Zovo, K.; Chung, R.S.; Howells, C.; West, A.K.; Palumaa, P. (2009). Zn(II) and Cu(II)-induced nonfibrillar aggregates of amyloid-beta peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. Journal of Neurochemistry, 110, 1784−1795.DOI:10.1111/j.1471-4159.2009.06269.x.
3.1.
2009
Karafin, A.; Palumaa, P.; Tõugu, V. (2009). Monitoring of Aβ fibrillization using an improved fluorimetric method. New Trends in Alzheimer and Parkinson Disorders: ADPD 2009: Alzheimer's and Parkinson's Diseases: Advances, Concepts and New Challenges. 9th International Conference AD/PD 2009. Prague, Czech Republic, March 11-15, 2009. Ed. Fisher, A.; Hanin, I. Bologna, Italy: Medimond, 255−259.
5.2.
2009
Palumaa, Peep; Karafin, Ann; Zovo, Kairit; Chung, Roger S.; Howells, Claire; West, Adrian K.; Tõugu, Vello (2009). Effect of Zn(II) and Cu(II) ions on aggregation and fibrillation of amyloid-β(1-42) peptide. Abstract Book: Sinapsa Neuroscience Conference '09, LjUbljana 26th - 29th September 2009. Toim. Kortnik, Blaž; Oskedar, Damian; Vodušek, Vid V. Ljubljana, Slovenia: SiNAPSA, Slovenian Neuroscience Association, 34.
5.2.
2009
Karafin, Ann; Palumaa, Peep; Tõugu, Vello (2009). Monitoring of amyloid-beta fibrillization using an improved fluorimetric method. In: (799−799).Alzheimer's and Parkinson's Diseases Advances, Concepts and New Challenges Congress, Prague, March 2009. Karger.
5.2.
2009
Karafin, A.; Tõugu, V.; Palumaa, P. (2009). Monitoring of amyloid-beta fibrillization using an improved fluorimetric method. Neurodegenerative Diseases, 6: 9th International Conference AD/PD, Prague, March 2009. Ed. Fisher, A.; Hanin, I.; Nitsch, R.M.; Windisch, M. Karger, 799. (Suppl. 1).
1.1.
2008
Tõugu, Vello;Karafin, Ann;Palumaa, Peep (2008). Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-β peptide. Journal of Neurochemistry, 104, 1249−1259.
5.1.
2008
Karafin, A; Palumaa, P; Tougu, V. (2008). Interactions of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-B peptide in vitro. FEBS Journal: 33rd FEBS Meeting, Athens, June 28-July 3, 2008. 222−222. (275).
22.04.2019

Ann Tiiman

https://www.etis.ee/CV/Ann_Tiiman/eng
3.10.1984
6204412
tiimanann@gmail.com
Maiden name: Karafin

Career

Institution(s) and position(s)
01.02.2010–31.08.2010   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Other staff (1,00)
2006–2008   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Genomics and Proteomics, Other staff (0,50)
 
 
Education
2009–2012   
Tallinn University of Technology, Faculty of Science, Department of Gene Technology, PhD student
2007–2009   
Tallinn University of Technology, Faculty of Science, Department of Gene Technology, Master degree
2003–2007   
Tallinn University of Technology, Faculty of Science, Department of Gene Technology, Bachelor degree
 
 
R&D related managerial and administrative work
2007−...   

Qualifications

Academic degrees
Ann Tiiman, Doctor's Degree, 2012, (sup) Peep Palumaa; Vello Tõugu, Interactions of Alzheimer’s amyloid-beta peptides with Zn(II) and Cu(II) ions, Tallinn University of Technology Faculty of Science, Department of Gene Technology.
Ann Tiiman, Master's Degree, 2009, (sup) Vello Tõugu; Peep Palumaa, Zn(II) and Cu(II) induced aggregation and fibrillation of Alzheimer’s amyloid-beta peptide, Tallinn University of Technology Faculty of Science, Department of Gene Technology.
 
 
Honours & awards
2012, Ann Tiiman, Estonian National Competition of Student Research Works, I place
2011, Ann Tiiman, Tiina Mõis scholarship
2010, Ann Tiiman, Estonian Biochemical Society Student Prize, I place
2010, Ann Tiiman, World Federation of Scientists scholarship
2009, Ann Tiiman, Estonian National Competition of Student Research Works, III place
2009, Ann Tiiman, Estonian Academy of Sciences, 2nd award in student reasearch contest
2008, Ann Tiiman, Estonian Biochemical Society Student Prize, I place
2007, Ann Tiiman, Estonian National Competition of Student Research Works, III place
 
 
Field of research
FIELD OF RESEARCH: 4. Natural Sciences and Engineering; 4.16. Biotechnology relating to Natural Sciences and Engineering
 
 

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2013
Wärmlander, Sebastian; Tiiman, Ann; Abelein, Axel; Luo, Jinghui; Jarvet, Jüri; Söderberg, Kajsa L; Danielsson, Jens; Gräslund, Astrid. (2013). Biophysical Studies of the Amyloid beta-Peptide: Interactions with Metal Ions and Small Molecules. Chembiochem : a European journal of chemical biology, 14 (14), 1692−1704.
1.1.
2013
Tiiman, Ann; Noormägi, Andra; Friedemann, Merlin; Krishtal, Jekaterina; Palumaa, Peep; Tõugu, Vello (2013). Effect of agitation on the peptide fibrillization: Alzheimer’s amyloid- b peptide 1-42 but not amylin and insulin fibrils can grow under quiescent conditions. Journal of Peptide Science, 19, 386−391.
1.1.
2013
Tiiman, Ann; Palumaa, Peep; Tõugu, Vello (2013). The Missing Link in the Amyloid Cascade of Alzheimer's Disease - Metal Ions. Neurochemistry International, 62 (4), 367−378.
5.2.
2012
Tiiman, Ann; Tõugu, Vello; Palumaa, Peep (2012). Interactions of Alzheimer’s Amyloid-beta Peptides with Zn(II) and Cu(II) Ions. In: .3rd Scandinavian Meeting on Amyloid Proteins and Disease, Sigtuna, Sweden, October 25-27 2012.
1.1.
2011
Tõugu, Vello; Tiiman, Ann; Palumaa, Peep (2011). Interactions of Zn(II) and Cu(II) ions with Alzheimer’s amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity. Metallomics, 3, 250−261.10.1039/c0mt00073f.
1.1.
2010
Zovo, Kairit; Helk, Eneken; Karafin, Ann; Tõugu, Vello; Palumaa, Peep (2010). Label-Free High-Throughput Screening Assay for Inhibitors of Alzheimer’s Amyloid-β Peptide Aggregation Based on MALDI MS. Analytical Chemistry, 82 (20), 8558−8565.10.1021/ac101583q.
1.1.
2009
Tõugu, V.; Karafin, A.; Zovo, K.; Chung, R.S.; Howells, C.; West, A.K.; Palumaa, P. (2009). Zn(II) and Cu(II)-induced nonfibrillar aggregates of amyloid-beta peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators. Journal of Neurochemistry, 110, 1784−1795.DOI:10.1111/j.1471-4159.2009.06269.x.
3.1.
2009
Karafin, A.; Palumaa, P.; Tõugu, V. (2009). Monitoring of Aβ fibrillization using an improved fluorimetric method. New Trends in Alzheimer and Parkinson Disorders: ADPD 2009: Alzheimer's and Parkinson's Diseases: Advances, Concepts and New Challenges. 9th International Conference AD/PD 2009. Prague, Czech Republic, March 11-15, 2009. Ed. Fisher, A.; Hanin, I. Bologna, Italy: Medimond, 255−259.
5.2.
2009
Palumaa, Peep; Karafin, Ann; Zovo, Kairit; Chung, Roger S.; Howells, Claire; West, Adrian K.; Tõugu, Vello (2009). Effect of Zn(II) and Cu(II) ions on aggregation and fibrillation of amyloid-β(1-42) peptide. Abstract Book: Sinapsa Neuroscience Conference '09, LjUbljana 26th - 29th September 2009. Toim. Kortnik, Blaž; Oskedar, Damian; Vodušek, Vid V. Ljubljana, Slovenia: SiNAPSA, Slovenian Neuroscience Association, 34.
5.2.
2009
Karafin, Ann; Palumaa, Peep; Tõugu, Vello (2009). Monitoring of amyloid-beta fibrillization using an improved fluorimetric method. In: (799−799).Alzheimer's and Parkinson's Diseases Advances, Concepts and New Challenges Congress, Prague, March 2009. Karger.
5.2.
2009
Karafin, A.; Tõugu, V.; Palumaa, P. (2009). Monitoring of amyloid-beta fibrillization using an improved fluorimetric method. Neurodegenerative Diseases, 6: 9th International Conference AD/PD, Prague, March 2009. Ed. Fisher, A.; Hanin, I.; Nitsch, R.M.; Windisch, M. Karger, 799. (Suppl. 1).
1.1.
2008
Tõugu, Vello;Karafin, Ann;Palumaa, Peep (2008). Binding of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-β peptide. Journal of Neurochemistry, 104, 1249−1259.
5.1.
2008
Karafin, A; Palumaa, P; Tougu, V. (2008). Interactions of zinc(II) and copper(II) to the full-length Alzheimer's amyloid-B peptide in vitro. FEBS Journal: 33rd FEBS Meeting, Athens, June 28-July 3, 2008. 222−222. (275).
22.04.2019
Detailne otsing
  • Leitud 6 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF9318Alheimeri amüloid-beeta fibrillide moodustumine, toksilisus ja võrdlus teiste amüloidsete peptiididega01.01.201231.12.2015Vello TõuguTallinna Tehnikaülikool, Matemaatika-loodusteaduskond48 000,00 EUR
ETFETF6840Alzheimeri amüloid beeta peptiidi ekspressioon, interaktsioonid metallidega ja metallide mõju amüloidsete peptiidide agregatsioonile.01.01.200631.12.2009Vello TõuguTallinna Tehnikaülikool, Matemaatika-loodusteaduskond51 934,09 EUR
SFSF0140055s08Struktuurne ja meditsiiniline metalloproteoomika01.01.200831.12.2013Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond937 814,19 EUR
IUTIUT19-8Struktuurne ja meditsiiniline metalloproteoomika01.01.201431.12.2019Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut; Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut1 248 000,00 EUR
ETFETF7191Tsütokroom c vase oksüdaasi vase šaperoonide struktuur ja toimemehhanismid01.01.200731.12.2010Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond54 053,92 EUR
ETFETF8811Uudsed mass-spektroskoopial põhinevad metoodikad vase ja tsingi valkude metallide sidumisomaduste ja redoksregulatsiooni uurimiseks01.01.201131.12.2014Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond77 112,00 EUR