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Csaba Hetényi

https://www.etis.ee/CV/Csaba_Hetényi/est
19.08.1976
+36302633559
csabahete@yahoo.com

Teenistuskäik

Töökohad ja ametid
01.01.2009–...   
Department of Genetics, Eötvös University, Hungary, Bolyai Fellow
03.07.2006–31.07.2007   
Tartu Ülikool, Füüsika-keemiateaduskond, Keemilise füüsika instituut, erakorraline vanemteadur (1,00)
01.01.2005–31.12.2005   
Department of Cell and Molecular Biology, Uppsala University, Sweden, Eötvös Travel Fellow
01.01.2003–31.12.2006   
Eötvös University, Budapest, Hungary, Bekesy Fellow of the Hungarian Ministry of Education
01.01.2002–31.12.2003   
Tartu Ülikool, Füüsika-keemiateaduskond, Keemilise füüsika instituut, Postdoctoral Fellow
01.01.2000–31.12.2001   
Tripep AB, Karolinska Institute, Huddinge, Sweden, Researcher
01.01.1999–31.12.2002   
University of Szeged, Hungary, PhD student
01.01.1999–31.12.2000   
Department of Biochemistry, Uppsala University, Sweden
 
 
Haridustee
1999–2002   
Pharmacy, PhD, summa cum laude, University of Szeged, Hungary
1994–1999   
Chemist, MSc degree, with honours, University of Szeged, Hungary

Kvalifikatsioon

Teaduspreemiad ja tunnustused
2009, Csaba Hetényi, Eötvös Fellowship
2005, Csaba Hetényi, Eötvös Fellowship
2003, Csaba Hetényi, Bekesy Fellowship
2002, Csaba Hetényi, Postdoctoral Fellowship
1999, Csaba Hetényi, Special Prize of the Hungarian Chemical Society
1999, Csaba Hetényi, TEMPUS Fellowship
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 4. Loodusteadused ja tehnika; 4.11. Keemia ja keemiatehnika
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; TÄPSUSTUS: In silico molecular design and engineering.

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2009
Kipper, K.; Hetényi, C.; Sild, S.; Remme, J.; Liiv, A. (2009). Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity. Journal of Molecular Biology, 385 (2), 405−422. DOI: 10.1016/j.jmb.2008.10.065.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376. DOI: 10.1038/embor.2008.11.
1.1.
2007
Hétenyi, Csaba; Maran, Uko; García-Sosa, Alfonso T.; Karelson, Mati (2007). Structure-based calculation of drug efficiency indices. Bioinformatics, 23 (20), 2678−2685. DOI: 10.1093/bioinformatics/btm431.
1.1.
2007
Malnasi-Csizmadia, A.; Toth, J.; Pearson, D.S.; Hetenyi, C.; Nyitray, L.; Geeves, M.A.; Bagshaw, C.R.; Kovacs, M. (2007). Selective perturbation of the Myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release. Journal of Biological Chemistry, 282 (24), 17658−17664.
1.1.
2007
Balogh, B.; Hetenyi, C.; Keseru, G.; Matyus, P. (2007). Structure-Based Calculation of Binding Affinities of alpha(2A)-Adrenoceptor Agonists. ChemMedChem, 2 (6), 801−805.
1.3.
2007
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U.; Mollica, L.; Musco, G.; Peterson, P. (2007). Autoimmuunsuse regulaator (AIRE) valgu PHD tsink sõrm seondub geeniekspressiooni aktiviseerimiseks mittemetüleeritud histoon H3K4-ga. Eesti Arst, 9, 685.
5.1.
2007
Bespalov, M. M.; Hetenyi, C.:; Turnova, S.; Hienola, A.; Sidorova, Y.; Rauvala, H.; Karelson, M.; Saarma, M. (2007). GDNF receptors as a drug target for neural repair. Cell Transplantation, 16 (3), 313−314.
1.1.
2006
Hodi, Z.; Nemeth, A.L.; Radnai, L.; Hetenyi, C.; Schlett, K.; Bodor, A.; Perczel, A.; Nyitray, L. (2006). Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dynein. Biochemistry, 45 (41), 12582−12595. DOI: 10.1021/bi060991e.
1.1.
2006
Hetényi, C.; van der Spoel, D. (2006). Blind docking of drug-sized compounds to proteins with up to a thousand residues. FEBS Letters, 580 (5), 1447−1450.
1.1.
2006
Hetenyi, C.; Paragi, G.; Maran, U.; Timar, Z.; Karelson, M.; Penke, B. (2006). Combination of a modified scoring function with two-dimensional descriptors for calculation of binding affinities of bulky, flexible ligands to proteins. Journal of the American Chemical Society, 128 (4), 1233−1239.
1.1.
2005
Fodor, K.; Harmat, V.; Hetényi, C.; Kardos, J.; Antal, J.; Perczel, A.; Patthy, A.; Katona, G.; Graf, L. (2005). Extended intermolecular interactions in a serine protease-canonical inhibitor complex account for strong and highly specific inhibition. Journal of Molecular Biology, 350 (1), 156−169.
1.1.
2005
Debreczeni, J.; Farkas, L.; Harmat, V.; Hetényi, C.; Hajdu, I.; Zavodszky, P.; Kohama, K.; Nyitray, L. (2005). Structural evidence for non-canonical binding of Ca2+ to a canonical EF-hand of a conventional myosin. Journal of Biological Chemistry, 280 (5), 41458−41464.
5.1.
2005
Hodi, Z; Nemeth, A; Kovacs, E; Hetenyi, C; Bodor, A; Perczel, A; Nyitray, L. (2005). The dynein light chain binds to a non-coiled-coil tail domain of myosin-Va that includes an alternatively spliced exon coding for three amino acid residues. FEBS JOURNAL, 272 . 335.
5.1.
2005
Graf, L.; Fodor, K.; Szenthe, B.; Perczel, A.; Gaspari, Z.; Harmat, V.; Hetenyi, C.; Antal, J.; Kardos, J.; Katona, G.; Patthy, A. (2005). Protease inhibitors of the grasshopper family: structure, molecular flexibility, specificity and mechanism of action. FEBS JOURNAL, 272. 250−251.
5.1.
2005
Fodor, K.; Harmat, V.; Kardos, J.; Antal, J.; Hetenyi, C.; Perczel, A.; Szenthe, B.; Gaspari, Z.; Katona, G.; Graf, L. (2005). Conformational adaptation of a canonical protease inhibitor upon its binding to the target protease increases specificity. FEBS JOURNAL, 272. 167.
1.1.
2004
Kovács, M.; Toth, J.; Hetényi, C.; Malnasi-Csizmadia, A.; Sellers, J.R. (2004). Mechanism of blebbistatin inhibition of myosin II. Journal of Biological Chemistry, 279 (34), 35557−35563.
1.1.
2004
Datki, Z.; Papp, R.; Zadori, D.; Soos, K.; Fulop, L.; Juhasz, A.; Laskay, G.; Hetényi, C.; Mihalik, E.; Zarandi, M.; Penke, B. (2004). In vitro model of neurotoxicity of A beta 1-42 and neuroprotection by a pentapeptide: irreversible events during the first hour. Neurobiology of Disease, 17 (3), 507−515.
1.1.
2003
Berkesi, O.; Körtvélyesi, T.; Hetényi, C.; Németh, T.; Pálinkó, I. (2003). Hydrogen bonding interactions of benzylidene type Schiff bases studied by vibrational spectroscopic and computational methods. Physical Chemistry Chemical Physics, 5 (10), 2009−2014.
1.1.
2003
Penke, B.; Datki, Z.; Hetényi, C.; Molnar, Z.; Lengyel, I.; Soos, K.; Zarandi, M. (2003). Molecular pathomechanisms of Alzheimer’s disease. Journal of Molecular Structure-Theochem, 666, 507−513.
1.1.
2003
Hetenyi, C.; Maran, U.; Karelson, M. (2003). A comprehensive docking study on the selectivity of binding of aromatic compounds to proteins. Journal of Chemical Information and Computer Sciences, 43 (5), 1576−1583.
1.1.
2002
Hetényi, C.; Körtvélyesi, T.; Penke, B. (2002). Mapping of the possible binding sequences of two beta-sheet breaker peptides on beta amyloid peptide of Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 10 (5), 1587−1593.
1.1.
2002
Hetényi, C.; van der Spoel, D. (2002). Efficient docking of peptides to proteins without prior knowledge of the binding site. Protein Science, 11 (7), 1729−1737.
1.1.
2002
Hetényi, C.; Szabó, Z.; Klement, É.; Datki, Z.; Körtvélyesi, T.; Zarándi, M.; Penke, B. (2002). Pentapeptide amides interfere with the aggregation of beta amyloid peptide of Alzheimer’s disease. Biochemical and Biophysical Research Communications, 292 (4), 931−936.
1.1.
2001
Hetényi, C.; Körtvélyesi, T.; Penke, B. (2001). Computational studies on the binding of beta-sheet breaker (BSB) peptides on amyloid betaA(1-42). Journal of Molecular Structure-Theochem, 542, 25−31.
1.1.
2001
Tong, D.; Hetényi, C.; Bikádi, Z.; Gao, J.-P.; Hjertén, S. (2001). Some studies of the chromatographic properties of gels (’artificial antibodies/receptors’) for selective adsorption of proteins. Chromatographia, 54, 7−14.
5.1.
2001
Kortvelyesi, T.; Camacho, C.J.; Hetenyi, C.; Penke, B.; Vajda, S. (2001). Binding of beta-sheet breaker peptides on amyloid beta A peptide fragments. Abstracts of Papers of the American Chemical Society, 222. U402.
1.1.
2000
Végvári, Á.; Földesi, A.; Hetényi, C.; Kochegarova, O.; Schmid, M.G.; Kudirkaite, V.; Hjertén, S. (2000). A new easy-to-prepare homogeneous continuous electrochromatographic bed for enantiomer recognition. Electrophoresis, 21 (15), 3116−3125.

Tööstusomand

6.02.2020

Csaba Hetényi

https://www.etis.ee/CV/Csaba_Hetényi/eng
19.08.1976
+36302633559
csabahete@yahoo.com

Career

Institutions and positions
01.01.2009–...   
Department of Genetics, Eötvös University, Hungary, Bolyai Fellow
03.07.2006–31.07.2007   
University of Tartu, Faculty of Physics and Chemistry, Institute of Chemical Physics, Senior Research Fellow extraordinarius (1,00)

Qualifications

Honours & awards
2009, Csaba Hetényi, Eötvös Fellowship
2005, Csaba Hetényi, Eötvös Fellowship (Hungarian)
2003, Csaba Hetényi, Bekesy Fellowship (Hungarian)
2002, Csaba Hetényi, Postdoctoral Fellowship of EU project IMAGETOX
1999, Csaba Hetényi, Special Prize of the Hungarian Chemical Society
1999, Csaba Hetényi, TEMPUS Fellowship
 
 
Fields of research
ETIS CLASSIFICATION: 4. Natural Sciences and Engineering; 4.11. Chemistry and Chemical Technology
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences

Publications

Category
Year
Publication
 
1.1.
2009
Kipper, K.; Hetényi, C.; Sild, S.; Remme, J.; Liiv, A. (2009). Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity. Journal of Molecular Biology, 385 (2), 405−422. DOI: 10.1016/j.jmb.2008.10.065.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376. DOI: 10.1038/embor.2008.11.
1.1.
2007
Hétenyi, Csaba; Maran, Uko; García-Sosa, Alfonso T.; Karelson, Mati (2007). Structure-based calculation of drug efficiency indices. Bioinformatics, 23 (20), 2678−2685. DOI: 10.1093/bioinformatics/btm431.
1.1.
2007
Malnasi-Csizmadia, A.; Toth, J.; Pearson, D.S.; Hetenyi, C.; Nyitray, L.; Geeves, M.A.; Bagshaw, C.R.; Kovacs, M. (2007). Selective perturbation of the Myosin recovery stroke by point mutations at the base of the lever arm affects ATP hydrolysis and phosphate release. Journal of Biological Chemistry, 282 (24), 17658−17664.
1.1.
2007
Balogh, B.; Hetenyi, C.; Keseru, G.; Matyus, P. (2007). Structure-Based Calculation of Binding Affinities of alpha(2A)-Adrenoceptor Agonists. ChemMedChem, 2 (6), 801−805.
1.3.
2007
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U.; Mollica, L.; Musco, G.; Peterson, P. (2007). Autoimmuunsuse regulaator (AIRE) valgu PHD tsink sõrm seondub geeniekspressiooni aktiviseerimiseks mittemetüleeritud histoon H3K4-ga. Eesti Arst, 9, 685.
5.1.
2007
Bespalov, M. M.; Hetenyi, C.:; Turnova, S.; Hienola, A.; Sidorova, Y.; Rauvala, H.; Karelson, M.; Saarma, M. (2007). GDNF receptors as a drug target for neural repair. Cell Transplantation, 16 (3), 313−314.
1.1.
2006
Hodi, Z.; Nemeth, A.L.; Radnai, L.; Hetenyi, C.; Schlett, K.; Bodor, A.; Perczel, A.; Nyitray, L. (2006). Alternatively spliced exon B of myosin Va is essential for binding the tail-associated light chain shared by dynein. Biochemistry, 45 (41), 12582−12595. DOI: 10.1021/bi060991e.
1.1.
2006
Hetényi, C.; van der Spoel, D. (2006). Blind docking of drug-sized compounds to proteins with up to a thousand residues. FEBS Letters, 580 (5), 1447−1450.
1.1.
2006
Hetenyi, C.; Paragi, G.; Maran, U.; Timar, Z.; Karelson, M.; Penke, B. (2006). Combination of a modified scoring function with two-dimensional descriptors for calculation of binding affinities of bulky, flexible ligands to proteins. Journal of the American Chemical Society, 128 (4), 1233−1239.
1.1.
2005
Fodor, K.; Harmat, V.; Hetényi, C.; Kardos, J.; Antal, J.; Perczel, A.; Patthy, A.; Katona, G.; Graf, L. (2005). Extended intermolecular interactions in a serine protease-canonical inhibitor complex account for strong and highly specific inhibition. Journal of Molecular Biology, 350 (1), 156−169.
1.1.
2005
Debreczeni, J.; Farkas, L.; Harmat, V.; Hetényi, C.; Hajdu, I.; Zavodszky, P.; Kohama, K.; Nyitray, L. (2005). Structural evidence for non-canonical binding of Ca2+ to a canonical EF-hand of a conventional myosin. Journal of Biological Chemistry, 280 (5), 41458−41464.
5.1.
2005
Hodi, Z; Nemeth, A; Kovacs, E; Hetenyi, C; Bodor, A; Perczel, A; Nyitray, L. (2005). The dynein light chain binds to a non-coiled-coil tail domain of myosin-Va that includes an alternatively spliced exon coding for three amino acid residues. FEBS JOURNAL, 272 . 335.
5.1.
2005
Graf, L.; Fodor, K.; Szenthe, B.; Perczel, A.; Gaspari, Z.; Harmat, V.; Hetenyi, C.; Antal, J.; Kardos, J.; Katona, G.; Patthy, A. (2005). Protease inhibitors of the grasshopper family: structure, molecular flexibility, specificity and mechanism of action. FEBS JOURNAL, 272. 250−251.
5.1.
2005
Fodor, K.; Harmat, V.; Kardos, J.; Antal, J.; Hetenyi, C.; Perczel, A.; Szenthe, B.; Gaspari, Z.; Katona, G.; Graf, L. (2005). Conformational adaptation of a canonical protease inhibitor upon its binding to the target protease increases specificity. FEBS JOURNAL, 272. 167.
1.1.
2004
Kovács, M.; Toth, J.; Hetényi, C.; Malnasi-Csizmadia, A.; Sellers, J.R. (2004). Mechanism of blebbistatin inhibition of myosin II. Journal of Biological Chemistry, 279 (34), 35557−35563.
1.1.
2004
Datki, Z.; Papp, R.; Zadori, D.; Soos, K.; Fulop, L.; Juhasz, A.; Laskay, G.; Hetényi, C.; Mihalik, E.; Zarandi, M.; Penke, B. (2004). In vitro model of neurotoxicity of A beta 1-42 and neuroprotection by a pentapeptide: irreversible events during the first hour. Neurobiology of Disease, 17 (3), 507−515.
1.1.
2003
Berkesi, O.; Körtvélyesi, T.; Hetényi, C.; Németh, T.; Pálinkó, I. (2003). Hydrogen bonding interactions of benzylidene type Schiff bases studied by vibrational spectroscopic and computational methods. Physical Chemistry Chemical Physics, 5 (10), 2009−2014.
1.1.
2003
Penke, B.; Datki, Z.; Hetényi, C.; Molnar, Z.; Lengyel, I.; Soos, K.; Zarandi, M. (2003). Molecular pathomechanisms of Alzheimer’s disease. Journal of Molecular Structure-Theochem, 666, 507−513.
1.1.
2003
Hetenyi, C.; Maran, U.; Karelson, M. (2003). A comprehensive docking study on the selectivity of binding of aromatic compounds to proteins. Journal of Chemical Information and Computer Sciences, 43 (5), 1576−1583.
1.1.
2002
Hetényi, C.; Körtvélyesi, T.; Penke, B. (2002). Mapping of the possible binding sequences of two beta-sheet breaker peptides on beta amyloid peptide of Alzheimer’s disease. Bioorganic & Medicinal Chemistry, 10 (5), 1587−1593.
1.1.
2002
Hetényi, C.; van der Spoel, D. (2002). Efficient docking of peptides to proteins without prior knowledge of the binding site. Protein Science, 11 (7), 1729−1737.
1.1.
2002
Hetényi, C.; Szabó, Z.; Klement, É.; Datki, Z.; Körtvélyesi, T.; Zarándi, M.; Penke, B. (2002). Pentapeptide amides interfere with the aggregation of beta amyloid peptide of Alzheimer’s disease. Biochemical and Biophysical Research Communications, 292 (4), 931−936.
1.1.
2001
Hetényi, C.; Körtvélyesi, T.; Penke, B. (2001). Computational studies on the binding of beta-sheet breaker (BSB) peptides on amyloid betaA(1-42). Journal of Molecular Structure-Theochem, 542, 25−31.
1.1.
2001
Tong, D.; Hetényi, C.; Bikádi, Z.; Gao, J.-P.; Hjertén, S. (2001). Some studies of the chromatographic properties of gels (’artificial antibodies/receptors’) for selective adsorption of proteins. Chromatographia, 54, 7−14.
5.1.
2001
Kortvelyesi, T.; Camacho, C.J.; Hetenyi, C.; Penke, B.; Vajda, S. (2001). Binding of beta-sheet breaker peptides on amyloid beta A peptide fragments. Abstracts of Papers of the American Chemical Society, 222. U402.
1.1.
2000
Végvári, Á.; Földesi, A.; Hetényi, C.; Kochegarova, O.; Schmid, M.G.; Kudirkaite, V.; Hjertén, S. (2000). A new easy-to-prepare homogeneous continuous electrochromatographic bed for enantiomer recognition. Electrophoresis, 21 (15), 3116−3125.

Industrial property

6.02.2020

Otsi projekti

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Asutus on projekti finantseerija   Asutus on projekti teostaja  
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Kõik   Tavaprojektid   Ülemprojektid   Alamprojektid  
Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
Lõppenud
Algus
Hajus
Täpne
Lihtotsing Tühjenda
  • Leitud 3 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0140031Bs09Arvutikeemia rakendusi olulise biomeditsiinilise ja keskonnaturbelise tähtsusega molekulaarsete süsteemide uurimisel01.01.200931.12.2014Uko MaranTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Keemia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond547 360,67 EUR
SFSF0182644Bs04Biotehnoloogiliste ja makromolekulaarsete süsteemide molekulaardisain01.01.200431.12.2008Uko MaranTartu Ülikool, Füüsika-keemiateaduskond291 692,77 EUR
MUUNFKKM06073Rahvusvahelisel tasemel kaasaegne molekulaartehnoloogia kraadiõpe ning teadus- ja arendustegevuse konkurentsivõime suurendamine01.07.200630.06.2008Uko MaranTartu Ülikool109 406,45 EUR