See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Ello-Rahel Karelson

https://www.etis.ee/CV/Ello-Rahel_Karelson/est
6.08.1946
737 4315
ello.karelson@ut.ee

Teenistuskäik

Töökohad ja ametid
01.02.2004–31.01.2009   
Tartu Ülikool, Arstiteaduskond, Biokeemia instituut, meditsiinilise biokeemia dotsent (1,00)
01.01.1994–31.12.1996   
TÜ Meditsiinilise Biokeemia Õppetooli hoidja
01.01.1979–31.12.1989   
1979-1989 vanemõpetaja, TÜ Biokeemia kateeder
01.01.1978–31.12.1979   
nooremteadur, TÜ Sekretoorsete Protsesside Biokeemia Laboratoorium
01.01.1972–31.12.1977   
vanemlaborant, TÜ Biokeemia kateeder ja Sekretoorsete Protsesside Biokeemia Laboratoorium
 
 
Haridustee
TÜ Arstiteaduskond, 1972.a.
TÜ Aspirantuur (biokeemia) 1977.a.
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
1979 -1996 Eesti biokeemia Seltsi Tartu osakonna sekretär
Rahvusvaliste konverentside orgkomiteede liige
Kahe rahvusvahelise eelretsenseeritava zurnaali referent
Mitmete bakalaureuse ja magistritööde retsensent

Kvalifikatsioon

Teaduskraadid
Ello-Rahel Karelson, doktorikraad, 1999, (juh) Ülo Langel, Modulation of adenylate cyclase activity in the rat hippocampus by neuropeptide galanin and its chimeric analogs, Tartu Ülikool.
Ello-Rahel Karelson, doktorikraad, 1977, (juh) -, The role of brain Na,K-ATPase in the mechanism of central effects of some neurotropic drugs (in Russian), Tartu Ülikool, Arstiteaduskond.
 
 
Teaduspreemiad ja tunnustused
2004, Ello-Rahel Karelson, Rootsi Dementsiafondi "DemensFonden" stipendiaat Stockholmi Ülikoolis ja Karolinska Instituudis
2003, Ello-Rahel Karelson, Rahvusvahelise Wenner-Gren fondi stipendiaat Stockholmi Ülikoolis
2002, Ello-Rahel Karelson, Rootsi Kuningliku Akadeemia Stipendiaat Stockholmi Ülikoolis
2000, Ello-Rahel Karelson, Rootsi Instituudi Stipendiaat Stockholmi Ülikoolis
1998, Ello-Rahel Karelson, Rootsi Instituudi stipendiaat Stockholmi Ülikoolis
1995, Ello-Rahel Karelson, Põhjamaade Minstrite Nõukogu Stipendiaat Turu Akadeemilises Ülikoolis (Soome)
 
 
Teadustöö põhisuunad
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin; PÕHISUUND: 1. Neuropeptiidide sh. amüloid-beeta peptiidide ja neuroprptektorite sh. östrogeenide ja isoflavonoidide molekulaarsed mehhanismid aju G-valk-vahendatud signaalradade tasandil normaalsel vananemisel ja neurodegeratsiooni puhul
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin; PÕHISUUND: 2. Aju ioon-pumbad neuropeptiidide, neurotoksiliste agensite ja neurodegeneratsiooni märklauana
 
 
Lisainfo
meditsiinikandidaat
meditsiinidoktor
Kõrgem Atestatsiooni Komisjon (Moskva), 1978;
TÜ Arstiteaduskonna kraadinõukogu, 1999
Osalemine töögrupi rahvusvahelises koostöös: Karolinska Instituudi Geraatria osak , Dr. N. Bogdanovic (oksüdatiivse stressi, signaaltransduktsiooni ja bioregulaatorite toimemehhanismide uurimine vananevas ja degeneratiivses inimajus postmortem). Osalemine Eesti-siseses koostöös: Tallinna Ülikool, Loodusteaduste osak, prof. T. Land (muteeritud amüloid-beeta peptiidide neurotoksiliste mehhanismide uurimine); Tartu Ülikooli Farmakoloogia instituut ( amüloid-beeta peptiidide neurotoksiliste mehhanismide uurimine) ja Füsioloogia instituut (neurodegeneratsiooni molekulaarsete mehhanismide uurimine erinevatel mudelsüsteemidel).

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2007
Jefremov, V.; Zilmer, M.; Zilmer, K.; Bogdanovic, N.; Karelson, E. (2007). Antioxidative effects of plant polyphenols: from protection of G-protein signaling to prevention of age-related pathologies. Annals of the New York Academy of Sciences, 1095, 449−457.
1.1.
2007
Reis, K.; Zharkovsky, A.; Bogdanovic, N.; Karelson, E.; Land, T. (2007). Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723). Neuroscience, 144 (2), 571−578.
1.1.
2006
Roots, K.; Kairane, C.; Salum, T.; Kõks, S.; Karelson, E.; Vasar, E.; Zilmer, M. (2006). Very low levels of cholecystokinin octapeptide activate Na-pump in the cerebral cortex of CCK2 receptor-deficient mice. International Journal of Developmental Neuroscience, 24 (6), 395−400.
1.1.
2005
Karelson, E.; Fernaeus, S.; Reis, K.; Bogdanovic, N.; Land, T. (2005). Stimulation of G-proteins in human control and Alzheimer's disease brain by FAD mutants of APP(714-723): implication of oxidative mechanisms. Journal of Neuroscience Research, 79 (3), 368−374.
1.1.
2003
Mahlapuu, R.; Viht, K.; Balaspiri, L.; Bogdanovic, N.; Saar, K.; Soomets, U.; Land, T.; Zilmer, M.; Karelson, E.; Langel, U. (2003). Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain. Molecular Brain Research, 117 (1), 73−82.
1.1.
2003
Roots, K.; Kõks, S.; Kairane, C.; Salum, T.; Karelson, E.; Vasar, E.; Zilmer, M. (2003). Na-pump kinetic properties are differently altered in the brain regions of the cholecystokinin(2) receptor-deficient mice. Annals of the New York Academy of Sciences, 986, 644−645.
1.1.
2002
Kairane, C.; Roots, K.; Uusma, T.; Bogdanovic, N.; Karelson, E.; Koks, S.; Zilmer, M. (2002). Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: difference from the age-matched control but similarity to the rat model. FEBS Letters, 531 (2), 241−244.
1.1.
2002
Karelson, E.; Mahlapuu, R.; Zilmer, M.; Soomets, U.; Bogdanovic, N.; Langel, U. (2002). Possible signaling by glutathione and its novel analogue through potent stimulation of frontocortical G proteins in normal aging and in Alzheimer's disease. Annals of the New York Academy of Sciences, 973, 537−540.
1.1.
2001
Karelson, E.; Bogdanovic, N.; Garlind, A.; Winblad, B.; Zilmer, K.; Kullisaar, T.; Vihalemm, T.; Kairane, C.; Zilmer, M. (2001). The cerebrocortical areas in normal brain aging and in Alzheimer's disease: Noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochemical Research, 26 (4), 353−361.
1.1.
2001
Bogdanovic, N.; Zilmer, M.; Zilmer, K.; Rehema, A.; Karelson, E. (2001). The Swedish APP670/671 Alzheimer's disease mutation: The first evidence for strikingly increased oxidative injury in the temporal inferior cortex. Dementia and Geriatric Cognitive Disorders, 12 (6), 364−370.

Ello-Rahel Karelson

https://www.etis.ee/CV/Ello-Rahel_Karelson/eng

Career

Education
Faculty of Medicine, University of Tartu, 1972
University of Tartu, Postgraduate studentship (biochemistry),1977
 
 
R&D related managerial and administrative work
1979 -1996 Secretary of Estonian Biochemical Society (Section of Tartu)
The member of Organizing Committees of International Conferences
Reviewer of two international peer-reviewd journals
Reviewer of many Baccalaureate and Master thesis

Qualifications

Academic degrees
Ello-Rahel Karelson, Doctor's Degree, 1999, (sup) Ülo Langel, Modulation of adenylate cyclase activity in the rat hippocampus by neuropeptide galanin and its chimeric analogs (Modulation of adenylate cyclase activity in the rat hippocampus by neuropeptide galanin and its chimeric analogs), University of Tartu.
Ello-Rahel Karelson, Doctor's Degree, 1977, (sup) -, The role of brain Na,K-ATPase in the mechanism of central effects of some neurotropic drugs (in Russian), University of Tartu, Faculty of Medicine.
 
 
Field of research
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine; SPECIALITY: 1. Molecular mechanisms of neuropeptides, incl. amyloid-beta peptides, and neuroprotectors, incl. estrogens and isoflavonoids, at the level of brain G-protein-mediated signalling pathways in normal aging and in neurodegeneration
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine; SPECIALITY: 2. Brain ion pumps as target for neuropeptides, neurotoxic agents and neurodegeneration
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine; SPECIALITY: 3. Molecular (incl. oxidative) mechanisms of Alzheimer's disease at the level of postmortal human brain
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine
 
 
Additional information
Doctor of Philosphy (Candidate of Medicine)
Doctor of Medicinae
Higher Atestation Commision (Moscow), 1978;
Council of the Faculty of Medicinae,
University of Tartu, 1999
Participation in international collaboration of work-group: Karolinska Institute, Geriatric Dep., Dr. N. Bogdanovic (investigation of mechanisms for oxidative stress, signal transduction and action of bioregulators in the aging and degenerative human brain post mortem). Participation in collaboration inside Estonia: University of Tallinn, Dep. of Natural Sciences, Prof. T.Land (investigation of neurotoxic mechanisms for mutated amyloid-beta peptides), University of Tartu, Dep. Pharmacology( investigation of neurotoxic mechanisms for amyloid-beta peptides) and Dep Physiology (investigation of molecular mechanisms of neurodegeneration in different model systems).

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2007
Jefremov, V.; Zilmer, M.; Zilmer, K.; Bogdanovic, N.; Karelson, E. (2007). Antioxidative effects of plant polyphenols: from protection of G-protein signaling to prevention of age-related pathologies. Annals of the New York Academy of Sciences, 1095, 449−457.
1.1.
2007
Reis, K.; Zharkovsky, A.; Bogdanovic, N.; Karelson, E.; Land, T. (2007). Critical role of methionine-722 in the stimulation of human brain G-proteins and neurotoxicity induced by London familial Alzheimer's disease (FAD) mutated V717G-APP(714-723). Neuroscience, 144 (2), 571−578.
1.1.
2006
Roots, K.; Kairane, C.; Salum, T.; Kõks, S.; Karelson, E.; Vasar, E.; Zilmer, M. (2006). Very low levels of cholecystokinin octapeptide activate Na-pump in the cerebral cortex of CCK2 receptor-deficient mice. International Journal of Developmental Neuroscience, 24 (6), 395−400.
1.1.
2005
Karelson, E.; Fernaeus, S.; Reis, K.; Bogdanovic, N.; Land, T. (2005). Stimulation of G-proteins in human control and Alzheimer's disease brain by FAD mutants of APP(714-723): implication of oxidative mechanisms. Journal of Neuroscience Research, 79 (3), 368−374.
1.1.
2003
Mahlapuu, R.; Viht, K.; Balaspiri, L.; Bogdanovic, N.; Saar, K.; Soomets, U.; Land, T.; Zilmer, M.; Karelson, E.; Langel, U. (2003). Amyloid precursor protein carboxy-terminal fragments modulate G-proteins and adenylate cyclase activity in Alzheimer's disease brain. Molecular Brain Research, 117 (1), 73−82.
1.1.
2003
Roots, K.; Kõks, S.; Kairane, C.; Salum, T.; Karelson, E.; Vasar, E.; Zilmer, M. (2003). Na-pump kinetic properties are differently altered in the brain regions of the cholecystokinin(2) receptor-deficient mice. Annals of the New York Academy of Sciences, 986, 644−645.
1.1.
2002
Kairane, C.; Roots, K.; Uusma, T.; Bogdanovic, N.; Karelson, E.; Koks, S.; Zilmer, M. (2002). Regulation of the frontocortical sodium pump by Na+ in Alzheimer's disease: difference from the age-matched control but similarity to the rat model. FEBS Letters, 531 (2), 241−244.
1.1.
2002
Karelson, E.; Mahlapuu, R.; Zilmer, M.; Soomets, U.; Bogdanovic, N.; Langel, U. (2002). Possible signaling by glutathione and its novel analogue through potent stimulation of frontocortical G proteins in normal aging and in Alzheimer's disease. Annals of the New York Academy of Sciences, 973, 537−540.
1.1.
2001
Karelson, E.; Bogdanovic, N.; Garlind, A.; Winblad, B.; Zilmer, K.; Kullisaar, T.; Vihalemm, T.; Kairane, C.; Zilmer, M. (2001). The cerebrocortical areas in normal brain aging and in Alzheimer's disease: Noticeable differences in the lipid peroxidation level and in antioxidant defense. Neurochemical Research, 26 (4), 353−361.
1.1.
2001
Bogdanovic, N.; Zilmer, M.; Zilmer, K.; Rehema, A.; Karelson, E. (2001). The Swedish APP670/671 Alzheimer's disease mutation: The first evidence for strikingly increased oxidative injury in the temporal inferior cortex. Dementia and Geriatric Cognitive Disorders, 12 (6), 364−370.
Detailne otsing
  • Leitud 5 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF_0182548As03Endoteeli düsfunktsionaalsuse ja neurodegeneratsiooni oksüdatiivse stressi põhine mudel01.01.200331.12.2007Mihkel ZilmerTartu Ülikool, Arstiteaduskond0,00 EUR
SFSF0182548As03Endoteeli düsfunktsionaalsuse ja neurodegeneratsiooni oksüdatiivse stressi põhine mudel01.01.200331.12.2007Mihkel ZilmerTartu Ülikool, Arstiteaduskond433 704,46 EUR
ETFETF6574Mitokondriaal-akonitaasne düsfunktsioon vananevas ja degeneratiivses ajus: mehhanismid ja ravivõimalused01.01.200631.12.2009Ceslava KairaneTartu Ülikool; Tartu Ülikool, Arstiteaduskond34 493,12 EUR
SFSF0180105s08Molekulaarsete-metaboolsete, funktsionaalsete ja struktuursete muutuste integratiivroll haiguste patogeneesis01.01.200831.12.2013Mihkel ZilmerTartu Ülikool, Arstiteaduskond846 468,60 EUR
ETFETF7333Raua ainevahetuse, oksüdatiivsete mehhanismide ja põletikuliste protsesside vaheliste seoste uurimine01.01.200831.12.2011Tiit LandTallinna Ülikool, Matemaatika ja Loodusteaduste Instituut86 296,05 EUR