23.10.1968
+358 400 316504
eric.dufour@tuni.fi
Rühmajuht Tampere (Soome)

Teenistuskäik

Töökohad ja ametid
01.09.2014–30.12.2019   
University of Tampere, Finland, grupijuht (1,00)
01.10.2009–30.10.2014   
University of Tampere, Finland, Soome Teaduste Akadeemia grupijuht (1,00)
 
 
Haridustee
01.09.2013–30.12.2019   
Lektor, magistrikursus “Biomeditsiini ja biotehnoloogia”
10.09.2012–30.06.2013   
Lektor, magistrikursus “Bioinformaatika”
30.09.2007–30.06.2010   
Lektor, magistrikursus “Biomeditsiini ja biotehnoloogia”
01.09.1999–30.06.2000   
Lektor, osalise tööajaga (ATER) Versailles’ Ülikoolis (Prantsusmaa)
01.09.1997–30.06.1999   
Tuutor Versailles' Ülikoolis (Prantsusmaa
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2014−2017   
Professor HT Jacobsi asetäitja Tampere Ülikooli laboris
2009−2019   
Tampere Ülikooli viiruste tuumiklabori direktor
 
 
Loometöö
31 teaduslikku artiklit, kõik eelretsenseeritavates ajakirjades.

>1800 tsiteeringut (ilma endatsiteeringuteta) >1600 artiklis, sealhulgas >500 ülevaate artiklites.

59 tsitaadi / avaldamist keskmine; h-indeks: 19.
.
 
 
Teenistuskäigu lisainfo
2008-2009. Uurimisprojekt: Alternatiivse oksüdaasi retroviraalne transgenees. Pirkanmaa sairaanhoitopiiri (Soome). 9 000 €. Saaja: Dr. Eric Dufour (järeldoktor).;
2009-2014 . Uurimisprojekt: Alternatiivset oksüdaasi ekspresseerivad hiire ja rakukultuuri mudelid: tööriistad mitokondri talitushäirete mõistmiseks ja kompenseerimiseks. Soome Teaduste Akadeemia. 737 361 € . Saaja : Dr. Eric Dufour (grupijuht). ;
2012-2014. Uurimisprojekt: Alternatiivne oksüdaasi ja NADH dehüdrogenaasi retroviraalne ekspressioon: vahend mitokondriaalsete patoloogiate prognoosiks, diagnostikaks ja võimalikuks raviks. Pirkanmaa sairaanhoitopiiri (Soome). 48 000 €. Saaja: Dr. Eric Dufour (grupijuht).;
2013-2016. Uurimisprojekt: Genoomiülene RNAi skriin eesmärgiga tuvastada uusi mitokondriaalsete haigustega seotud geene. United Mitochondrial Disease Foundation (USA). 100 000 $. Saaja: Dr Alberto Sanz (Dr. Eric Dufour on kaasfinantseeritav). ;
2014-2017. Uurimisprojekt: Modifitseerides kompleks I vastuseid OXPHOS häiretele; uus vahend mitokondriaalse haigustega võitlemiseks. Prantsuse Muskulaardüstroofia Assotsoatsioon (AFM). 100 000 €. Saaja: Dr. Eric Dufour (grupijuht). ;
2010-2013. Viiruste tuumiklabori rahastus: Biocenter Finland, 94 500 €. Saaja: Dr. Eric Dufour (tuumiklabori direktor). ;
2014-2015. Viiruste tuumiklabori rahastus: University of Tampere, 24 000 €. Saaja: Dr. Eric Dufour (tuumiklabori direktor). ;

Kvalifikatsioon

 
 
Teaduspreemiad ja tunnustused
2000, Eric Jean-Francois Dufour, Eric Jean-Francois Dufour, INSERMi / Medinskaya Institutet mobiilsus stipendium (Prantsusmaa /Rootsi)
2000, Eric Jean-Francois Dufour, Eric Jean-Francois Dufour, Eric Dufour doktoritöö sai kõrgeima akadeemilise hinnangu: "mention très honorable, avec félicitations du jury".
1999, Eric Jean-Francois Dufour, Eric Jean-Francois Dufour, doktoritöö stipendium Prantsuse Muskulaardüstroofia Assotsiatsioonilt (AFM).
1998, Eric Jean-Francois Dufour, Eric Jean-Francois Dufour, SBV-Novartis auhind parimaid suulise ettekande eest.
1996, Eric Jean-Francois Dufour, Eric Jean-Francois Dufour, doktoritöö stipendium teadusministeeriumilt (Prantsusmaa).
1995, Eric Jean-Francois Dufour, Eric Jean-Francois Dufour, magistritöö stipendium teadusministeeriumilt (Prantsusmaa)
 
 
Teadustöö põhisuunad
VALDKOND: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS ERIALA: P330 Bioenergeetika ; PÕHISUUND: Mitochondrial bioenergetics
VALDKOND: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS ERIALA: B210 Histoloogia, tsütokeemia, histokeemia, koekultuurid; PÕHISUUND: Cell biology of rare diseases
 
 
Lisainfo
Molekulaarbioloogia dotsent alates 2013 aastast Tampere Ülikoolis (Soome).

Publikatsioonid

Klass
Aasta
Publikatsioon
 
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2019
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2019
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2018
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1.1.
1997
18.04.2019
23.10.1968
+358 400 316504
eric.dufour@tuni.fi
Group Leader in Tampere (Finland)

Career

Institution(s) and position(s)
01.09.2014–30.12.2019   
University of Tampere, Finland, group leader (1,00)
01.10.2009–30.10.2014   
University of Tampere, Finland, Academy Research Fellow (1,00)
 
 
Education
01.09.2013–30.12.2019   
Delegate professor (for the Masters of Biomedicine and biotechnology)
10.09.2012–30.06.2013   
Delegate professor (for the Masters of Bioinformatics)
30.09.2007–30.06.2010   
Delegate assistant professor (for the Masters of Biomedicine and biotechnology)
01.09.1999–30.06.2000   
Limited-time teacher (ATER) at Versailles University (France)
01.09.1997–30.06.1999   
Tutor at Versailles University (France)
 
 
R&D related managerial and administrative work
2014−2017   
Deputy director of HT Jacobs laboratory in Tampere
2009−2019   
Director of BioMediTech Tampere Virus Facility
 
 
Creative work
31 publications, all in peer-reviewed journals.

>1800 citations (excluding self-citations) from >1500 documents including 500 review articles.

59 citation /publication in average; h-index: 19. .
 
 
Additional career information
2008-2009. Research Project : Retroviral transgenesis of the alternative oxidase. From Pirkanmaa Hospital District. 9 000€. Beneficiary: Dr. Eric Dufour (PostDoc researcher).;
2009-2014. Research Project: Mouse and cellular models expressing the alternative oxidase: tools to understand and compensate mitochondrial dysfunctions. Funded by the Academy of Sciences of Finland. 737 361€. Beneficiary: Dr. Eric Dufour (PI).;
2012-2014. Research project: Retroviral expression of the alternative oxidase and NADH dehydrogenase a tool to improve prognosis, diagnosis and a potential therapy for mitochondrial pathologies. Funded by Pirkanmaa Hospital District. 48 000€. Beneficiary: Dr. Eric Dufour (PI).;
2013-2016. Research project: Genome-wide RNAi Screening to Identify New Genes Involved in Mitochondrial Diseases. Funded by the United Mitochondrial Disease Foundation. 100 000$. Beneficiary: Dr. Alberto Sanz (Dr. Eric Dufour is co-recipient).;
2014-2017. Research project: Altering complex I response to OXPHOS dysfunctions; a new tool to combat mitochondrial diseases. Funded by the French Muscular Dystrophy Association (AFM). 100 000€. Beneficiary: Dr. Eric Dufour (PI).;
2010-2013. Facility support: Virus Core Facility Funding by Biocenter Finland. 94 500€. Beneficiary: Dr. Eric Dufour (Facility Director).;
2014-2015. Facility support: Viral core facility Funding by the University of Tampere. 24 000€. Beneficiary: Dr. Eric Dufour (Facility director). ;

Qualifications

 
 
Honours & awards
2000, Eric Jean-Francois Dufour, INSERM/Medinskaya-Institutet exchange Fellowship (France/Sweden
2000, Eric Jean-Francois Dufour, Eric Dufour's thesis received the highest academic distinction: "mention très honorable, avec félicitations du jury" ("Very Honorable, with Committee Praise".
1999, Eric Jean-Francois Dufour, PhD Thesis Scholarship from the French Muscular Dystrophy Association (AFM).
1998, Eric Jean-Francois Dufour, SBV-Novartis price for the best oral communication.
1996, Eric Jean-Francois Dufour, PhD Thesis Scholarship from the ministry of research (France).
1995, Eric Jean-Francois Dufour, Masters Scholarship from the ministry of research (France).
 
 
Field of research
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS SPECIALITY: P330 Bioenergetics ; SPECIALITY: Mitochondrial Bioenergetics
FIELD OF RESEARCH: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS SPECIALITY: B210 Histology, cytochemistry, histochemistry, tissue culture ; SPECIALITY: Cell biology of rare diseases
 
 
Additional information
Docent in Molecular genetics (2013), University of Tampere

Publications

Category
Year
Publication
 
1.1.
2019
1.1.
2019
1.1.
2018
1.1.
2018
1.1.
2018
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2017
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2017
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2013
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2000
1.1.
1999
1.1.
1997
18.04.2019
  • Leitud 31 kirjet
PublikatsioonAutoridAastaVäljaande pealkiriKlassifikaatorFailAsutused
Alternative respiratory chain enzymes: Therapeutic potential and possible pitfallsSaari, Sina; Garcia, Geovana S.; Bremer, Katharina; Chioda, Marina M.; Andjelkovic, Ana; Debes, Paul V.; Nikinmaa, Mikko; Szibor, Marten; Dufour, Eric; Rustin, Pierre; Oliveira, Marcos T.; Jacobs, Howard T.2019Biochimica et Biophysica Acta - Molecular Basis of Disease1.1.
RNase H1 promotes replication fork progression through oppositely transcribed regions of Drosophila mitochondrial DNA.Gonzalez de Cozar, JM; Gerards, M; Teeri, E; George, J; Dufour, E; Jacobs, HT; Joers, P.2019Journal of Biological Chemistry1.1.Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut
Expression of the Alternative Oxidase Influences Jun N-Terminal Kinase Signaling and Cell MigrationAndjelkovic, Ana; Mordas, Amelia; Bruinsma, Lyon; Ketola, Annika; Cannino, Giuseppe; Giordano, Luca; Dhandapani, Praveen K.; Szibor, Marten; Dufour, Eric; Jacobs, Howard T.2018Molecular and Cellular Biology1.1.
Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cellsToompuu, Marina; Tuomela, Tea; Laine, Pia; Paulin, Lars; Dufour, Eric; Jacobs, Howard T.2018Nucleic Acids Research1.1.
Priming of innate antimycobacterial immunity by heat-killed Listeria monocytogenes induces sterilizing response in the adult zebrafish tuberculosis modelLuukinen, H.; Hammarén, M. M.; Vanhaaho, L.-M.; Svorjova, A.; Kantanen, L.; Järvinen, S.; Luukinen, B.V.; Dufour, E.; Rämet, M.; Hytönen, V.P.; Parikka, M. 2018Disease Models & Mechanisms1.1.
Broad AOX expression in a genetically tractable mouse model does not disturb normal physiology.Szibor, Marten; Dhandapani, Praveen K; Dufour, Eric; Holmström, Kira M; Zhuang, Yuan; Salwig, Isabelle; Wittig, Ilka; Heidler, Juliana; Gizatullina, Zemfira; Gainutdinov, Timur; ,; Fuchs, Helmut; Gailus-Durner, Valérie; de Angelis, Martin Hrabě; Nandania, Jatin; Velagapudi, Vidya; Wietelmann, Astrid; Rustin, Pierre; Gellerich, Frank N; Jacobs, Howard T ... Braun, Thomas2017Disease models & mechanisms1.1.
Development of an inducible platform for intercellular protein delivery.Siller, Richard; Dufour, Eric; Lycke, Max; Wilmut, Ian; Jung, Yong-Wook; Park, In Hyun; Sullivan, Gareth J2017International Journal of Pharmaceutics1.1.
TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions.Martínez-Reyes, Inmaculada; Diebold, Lauren P; Kong, Hyewon; Schieber, Michael; Huang, He; Hensley, Christopher T; Mehta, Manan M; Wang, Tianyuan; Santos, Janine H; Woychik, Richard; Dufour, Eric; Spelbrink, Johannes N; Weinberg, Samuel E; Zhao, Yingming; DeBerardinis, Ralph J; Chandel, Navdeep S2016Molecular Cell1.1.
DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells.Kontro, Heidi; Cannino, Giuseppe; Rustin, Pierre; Dufour, Eric; Kainulainen, Heikki2015 PLoS ONE1.1.
Diiron centre mutations in Ciona intestinalis alternative oxidase abolish enzymatic activity and prevent rescue of cytochrome oxidase deficiency in flies.Andjelković, Ana; Oliveira, Marcos T; Cannino, Giuseppe; Yalgin, Cagri; Dhandapani, Praveen K; Dufour, Eric; Rustin, Pierre; Szibor, Marten; Jacobs, Howard T2015Scientific Reports1.1.
The hammer of TORC1!Dufour, Eric2015Cell Cycle1.1.
Engineering the alternative oxidase gene to better understand and counteract mitochondrial defects: state of the art and perspectives.El-Khoury, Riyad; Kemppainen, Kia K; Dufour, Eric; Szibor, Marten; Jacobs, Howard T; Rustin, Pierre2014British Journal of Pharmacology1.1.
Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis.Wheaton, William W; Weinberg, Samuel E; Hamanaka, Robert B; Soberanes, Saul; Sullivan, Lucas B; Anso, Elena; Glasauer, Andrea; Dufour, Eric; Mutlu, Gokhan M; Budigner, Gr Scott; Chandel, Navdeep S2014eLife1.1.
Screen for mitochondrial DNA copy number maintenance genes reveals essential role for ATP synthase.Fukuoh, Atsushi; Cannino, Giuseppe; Gerards, Mike; Buckley, Suzanne; Kazancioglu, Selena; Scialo, Filippo; Lihavainen, Eero; Ribeiro, Andre; Dufour, Eric; Jacobs, Howard T2014Molecular systems biology1.1.
Alternative oxidase expression in the mouse enables bypassing cytochrome c oxidase blockade and limits mitochondrial ROS overproduction.El-Khoury, Riyad; Dufour, Eric; Rak, Malgorzata; Ramanantsoa, Nelina; Grandchamp, Nicolas; Csaba, Zsolt; Duvillié, Bertrand; Bénit, Paule; Gallego, Jorge; Gressens, Pierre; Sarkis, Chamsy; Jacobs, Howard T; Rustin, Pierre2013PLOS Genetics1.1.
The proto-oncometabolite fumarate binds glutathione to amplify ROS-dependent signaling.Sullivan, Lucas B; Martinez-Garcia, Eva; Nguyen, Hien; Mullen, Andrew R; Dufour, Eric; Sudarshan, Sunil; Licht, Jonathan D; Deberardinis, Ralph J; Chandel, Navdeep S2013Molecular Cell1.1.
Glucose modulates respiratory complex I activity in response to acute mitochondrial dysfunction.Cannino, Giuseppe; El-Khoury, Riyad; Pirinen, Marja; Hutz, Bettina; Rustin, Pierre; Jacobs, Howard T; Dufour, Eric2012Jornal of Biological Chemistry1.1.
Expression of the alternative oxidase complements cytochrome c oxidase deficiency in human cells.Dassa, Emmanuel P; Dufour, Eric; Gonçalves, Sérgio; Paupe, Vincent; Hakkaart, Gertjan A J; Jacobs, Howard T; Rustin, Pierre2010EMBO Molecular Medicine1.1.
Expression of the yeast NADH dehydrogenase Ndi1 in Drosophila confers increased lifespan independently of dietary restriction.Sanz, Alberto; Soikkeli, Mikko; Portero-Otín, Manuel; Wilson, Angela; Kemppainen, Esko; McIlroy, George; Ellilä, Simo; Kemppainen, Kia K; Tuomela, Tea; Lakanmaa, Matti; Kiviranta, Essi; Stefanatos, Rhoda; Dufour, Eric; Hutz, Bettina; Naudí, Alba; Jové, Mariona; Zeb, Akbar; Vartiainen, Suvi; Matsuno-Yagi, Akemi; Yagi, Takao ... Jacobs, Howard T2010Proceedings of the National Academy of Sciences of the United States of America1.1.
Stabilization of hypoxia-inducible factor-1alpha protein in hypoxia occurs independently of mitochondrial reactive oxygen species production.Chua, Yee Liu; Dufour, Eric; Dassa, Emmanuel P; Rustin, Pierre; Jacobs, Howard T; Taylor, Cormac T; Hagen, Thilo2010Jornal of Biological Chemistry1.1.
The alternative oxidase, a tool for compensating cytochrome c oxidase deficiency in human cells.Dassa, Emmanuel P; Dufour, Eric; Goncalves, Sergio; Jacobs, Howard T; Rustin, Pierre2009Physiologia Plantarum1.1.
Age-associated mosaic respiratory chain deficiency causes trans-neuronal degeneration.Dufour, Eric; Terzioglu, Mügen; Sterky, Fredrik Hansson; Sörensen, Lene; Galter, Dagmar; Olson, Lars; Wilbertz, Johannes; Larsson, Nils-Göran2008Human Molecular Genetics1.1.
Mitochondrial metabolism and aging in the filamentous fungus Podospora anserina.Lorin, Séverine; Dufour, Eric; Sainsard-Chanet, Annie2006Biochimica et Biophysica Acta1.1.
SOD2 overexpression: enhanced mitochondrial tolerance but absence of effect on UCP activity.Silva, José P; Shabalina, Irina G; Dufour, Eric; Petrovic, Natasa; Backlund, Emma C; Hultenby, Kjell; Wibom, Rolf; Nedergaard, Jan; Cannon, Barbara; Larsson, Nils-Göran2005EMBO Journal1.1.
Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.Trifunovic, Aleksandra; Hansson, Anna; Wredenberg, Anna; Rovio, Anja T; Dufour, Eric; Khvorostov, Ivan; Spelbrink, Johannes N; Wibom, Rolf; Jacobs, Howard T; Larsson, Nils-Göran2005Proceedings of the National Academy of Sciences of the United States of America1.1.