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Olen nõus

Erkki Juronen

https://www.etis.ee/CV/Erkki_Juronen/est
24.02.1959
737 4217
erkki.juronen@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2014–...   
Icosagen Cell Factory OÜ, Vanemteadur (1,00)
01.01.2015–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, immunogeneetika ja immunokeemia vanemteadur (0,25)
01.04.2014–31.12.2014   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, immunogeneetika ja immunokeemia vanemteadur (0,75)
26.08.2013–31.03.2014   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, immunogeneetika ja immunokeemia vanemteadur (1,00)
21.05.2013–25.08.2013   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, immunogeneetika ja -keemia vanemteadur (1,00)
26.08.2008–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, immunogeneetika ja -keemia vanemteadur (1,00)
27.08.2003–25.08.2008   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, immunogeneetika ja -keemia vanemteadur (1,00)
1993–2013   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, Vanemteadur (1,00)
01.01.1988–31.12.1993   
Tartu Ülikool, Arstiteaduskond, Üld-ja molekulaarpatoloogia instituut; immuunanalüüsi labori juhataja
01.01.1986–31.12.1988   
Tartu Ülikool, aspirantuur molekulaarbioloogia erialal
01.01.1982–31.12.1986   
Tartu Ülikool, Arstiteaduskond, Üld-ja molekulaarpatoloogia instituut; nooremteadur
 
 
Haridustee
1977–1982   
Tartu Ülikooli bioloogia osakond, ihtüoloogia-hüdrobioloogia eriala
 
 
Lisainfo
Saadud uurimistoetused:
1) ETF grant 1358 “Glutatioon S-transferaas Teeta polümorfismi uurimine” (1995-1996);
2) ETF grant 3020 “Polümorfsete detoksifikatsioonoensüümide roll silmahaiguste tekkel eestlastel” (1997-1998);
3) ETF grant 4349 “Polümorfsed glutatioon S-transferaasid GSTM3, GSTP1 ja GSTZ1 eestlastel ning nende võimalik seos haigustundlikkusega” (2000-2003).
4) ETF grant 8981 "Membraaniga seotud mutsiinid kui kasvajate immuunoteraapia ja diagnostika sihtmolekulid." (2012-2015)
Tööstusomand: Teadus-arendustöö leping 11160-290910 TÜ ja Millipore Inc vahel laminiini ahelate vastaste antikehade turustamiseks
Sihtfinantseeritava teema SF0180096s08 "Inimese fetaalsete neuraalsete ja embrüonaalsete tüvirakkude differentseerumine neuraalses suunas ja uute immuunmarkerite loomine" juht (2008-2013)

Kvalifikatsioon

Teaduskraadid
Erkki Juronen, doktorikraad, 1988, (juh) Aavo-Valdur Mikelsaar, Моноклоналъные антитела к миоглобину человека (Inimese müoglobiini vastased monokloonsed antikehad), Tartu Ülikool, Arstiteaduskond.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.1. Biomeditsiin; TÄPSUSTUS: Monokloonsed antikehad geneetilistes ja tüviraku-uuringutes

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2014
Pook, M.; Tamming, L.; Padari, K.; Tiido, T.; Maimets, T.; Patarroyo, M.; Juronen, E.; Jaks, V.; Ingerpuu, S. (2014). Platelets store laminins 411/421 and 511/521 in compartments distinct from α- or dense granules and secrete these proteins via microvesicles. Journal of Thrombosis and Haemostasis, 12 (4), 519−527.10.1111/jth.12513.
5.2.
2014
Mikelsaar, A-V.; Vorobjova, A.; Saag, M.; Mikelsaar, Ruth; Juronen, E. (2014). Expression of mucins and glutathione-S-transferases in dental stem cells isolated from human third molar. Cytochemical study. Abstract of the 12th Annual Meeting of ISSCR (International Society for Stem Cell Research), Vancouver(Canada), 2014. F-L-4021.
1.1.
2013
Celojevic, D.; Nilsson, S.; Behndig, A.; Tasa, G.; Juronen, E., Karlsson, J.O.; Zetterberg, H.; Petersen, A.; Zetterberg, M. (2013). Superoxide Dismutase Gene Polymorphisms in Patients with Age-related Cataract. Ophthalmic Genetics, 34 (3), 140−145.10.3109/13816810.2012.746377.
1.1.
2013
Kärner, J.; Meager, A.; Laan, M.; Maslovskaja, J.; Pihlap, M.; Remm, A.; Juronen, E.; Wolff, A. S. B.; Husebye, E. S.; Podkrajšek, K. T.; Bratanic, N.; Battelino, T.; Willcox, N.; Peterson, P.; Kisand, K. (2013). Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice. Clinical and Experimental Immunology, 171 (3), 263−272.10.1111/cei.12024.
1.1.
2013
Wondimu, Z; Omrani, S; Ishikawa, T; Javed, F; Oikawa, Y; Virtanen, I; Juronen, E; Ingerpuu, S; Patarroyo, M (2013). A Novel Monoclonal Antibody to Human Laminin a5 Chain Strongly Inhibits Integrin-Mediated Cell Adhesion and Migration on Laminins 511 and 521. PLoS ONE, 8 (1), 1−11.10.1371/journal.pone.0053648.
5.2.
2013
Ustinova, Julia; Belitskin, Denis; Juronen, Erkki; Zusinaite, Eva; Utt, Meeme; Uibo, Raivo (2013). Characterization of monoclonal ZnT8-specific antibody. 15th International Congress of Immunology (ICI); Milan, Italy; 22 Aug - 27 Aug, 2013. DOI: 10.3389/conf.fimmu.2013.02.00326.
5.2.
2013
Mikelsaar, A.-V.; Masso, R.; Masso, M.; Sünter, A.; Mikelsaar, R.; Juronen, E. (2013). Titiin mittelihasrakkudes. Evolutsiooniline analüüs. Eesti Arst, 92. 37−37. (Lisa 2).
1.1.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, R.; Toomik, P.; Kõiveer, A.; Mikelsaar, I.; Juronen, E. (2012). Epitope of titin a-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells. Cell Division, 7, Art No 21.10.1186/1747-1028-7-21.
3.2.
2012
Mikelsaar Aavo-Valdur, Sünter Alar, Toomik Peeter, Karpson Kalmer, Juronen Erkki (2012). Development of new monoclonal antibodies for immunocytochemical characterization of neural stem and differentiated cells. In: Tao Sun (Ed.). Neural Stem Cells (93−118).. University Campus, STeP Ri Slavka Krautzeka 83/A 51000 Rijeka, Croatia: INTECH Open Access Publisher.
5.2.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, Ruth; Toomik, P.; Mikelsaar, I.; Juronen, E. (2012). Evolutionary aspects of centriole associated proteins. Europ J Human Genetics: European Human Genetics Conference 2012 in conj. with the European Meeting on Psychosocial Aspects of Genetics, Nürnberg. 251.
1.1.
2011
Rudolph, T.; Sjölander, A.; Palmér, M.S.; Minthon, L.; Wallin, A.; Andreasen, N.; Tasa, G.; Juronen, E.; Blennow, K.; Zetterberg, H.; Zetterberg, M. (2011). Ubiquitin Carboxyl-Terminal Esterase L1 (UCHL1) S18Y Polymorphism In Patients With Cataracts. Ophthalmic Genetics, 32 (2), 75−79.
3.1.
2011
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter; Mikelsaar, Ruth; Juronen, Erkki (2011). New data on the centrosome proteins. Chromosome Research. The Biology of Chromatin and Chromosomes, 19: 8th European Cytogenetics Conference, Altândega Congress & Exhibition Centre, Portugal, 2-5. july 2011. Springer, S199. (Supplement 1).
1.1.
2010
Mikelsaar, A-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Kalev, I.; Kõiveer, A.; Piirsoo, A.; Karpson, K.; Juronen, E. (2010). Titin A-band-specific Monoclonal Antibody Tit1 5H1.1. Cellular Titin As a Centriolar Protein in Non-muscle Cells. Hybridoma, 29 (5), 391−401.
1.1.
2010
Faustova, Ilona; Kuznetsov, Aleksei; Juronen, Erkki; Loog, Mart; Järv, Jaak (2010). Phosphorylation is switch of L-type pyruvate kinase allostery. Central European Journal of Biology, 5, 135−142.10.2478/s11535-010-0004-6.
5.2.
2010
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Juronen, E. (2010). Titin or a titin-like protein as a human centriolar protein? European Journal of Human Genetics, Supplement 1: European Human Genetics Conference 2010 in conjuction with European Meeting on Psychosocial Aspects of Genetics. Swedish Exhibition & Converence Centre: Nature Publishing Group, 109. (18).
1.1.
2009
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K.; Juronen, E. (2009). New Anti-Ku80 Monoclonal Antibody F10H2.B3 As a Useful Marker for Dividing Cells in Culture. Hybridoma, 107−111. DOI: 10.1089/hyb.2008.0077.
5.1.
2009
Mikelsaar, A.-V. ; Sünter, A.; Toomik, P.; Karpson, K. ; Mikelsaar, R.; Juronen, E.. (2009). The subcellular localisation of Ku80 during mitotic cycle - an immunocytochemical analysis using anti Ku80 Mab F10H2.B3. Chromosome Research, 17: 7th European Cytogenetics Conference, Stockholm, 4-7 July 2009. Ed. Herbert Macgregor. Dordrecht, The Netherlands/Norwel,MA,USA: Springer Heidelberg, S172−S172.
5.2.
2009
Orlova , Svetlana; Kõiveer, Anu; Juronen, Erkki; Piirsoo, Andres (2009). NEURAL DIFFERENTIATION OF HUMAN ES CELLS H9.2 AND I4 DERIVED EMBRYOID BODIES INDUCED BY RETINOIC ACID ON BD MATRIGEL. In: Abstracts of ISSCR 7th Annual Meeting (108).International Society for Stem Cell Research: ISSCR 7th Annual meeting; Barcelona, Spain; July 8-11, 2009. Barcelona , Spain 2009.
1.1.
2008
Nikonov, A.; Juronen, E.; Ustav, M. (2008). Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase. Journal of Biological Chemistry, 283 (35), 24089−24102. DOI: 10.1074/jbc.M803422200.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1783 (1), 74−83. DOI: 10.1016/j.bbamcr.2007.09.003.
1.1.
2007
Andersson, M.E.; Zetterberg, M.; Tasa, G.; Seibt-Palmér, M.; Juronen, E.; Teesalu, P.; Blennow, K.; Zetterberg, H. (2007). Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. Molecular Vision, 13, 993−996.
1.1.
2007
Zetterberg, M.; Tasa, G.; Palmér, M.S.; Juronen, E.; Toover, E.; Blennow, K.; Zetterberg, H. (2007). Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. Ophthalmic Genetics, 28 (2), 47−50.
1.1.
2007
Zetterberg, M.; Tasa, G.; Palmér, M.S.; Juronen, E.; Teesalu, P.; Blennow, K.; Zetterberg, H. (2007). Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma. American Journal of Ophthalmology, 143 (6), 1059−1060.
1.1.
2005
Zetterberg, M.; Tasa, G.; Prince, JA.; Palmer, M.; Juronen, E.; Veromann, S.; Teesalu, P.; Karlsson, JO.; Blennow, K.; Zetterberg, H. (2005). Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract. American Journal of Ophthalmology, 140 (5), 932−934.
1.1.
2004
Veromann, S.; Sunter, A.; Juronen, E.; Tasa, G.; Panov, A. (2004). Eye lens crystallins: A component of intraocular pseudoexfoliative material. Ophthalmic Research, 36 (1), 51−54.
1.1.
2004
Zetterberg, M.; Zetterberg, H.; Palmer, M.; Rymo, L.; Blennow, K.; Tasa, G.; Juronen, E.; Veromann, S.; Teesalu, P.; Zetterberg, M.; Karlsson, JO.; Hoglund, K. (2004). Apolipoprotein E polymorphism in patients with cataract. British Journal of Ophthalmology, 88 (5), 716−718.
1.1.
2004
Wondimu, Z.; Geberhiwot, T.; Ingerpuu, S.; Juronen, E.; Xie, X.; Lindbom, L.; Doi, M.; Kortesmaa, J.; Thyboll, J.; Tryggvason, K.; Fadeel, B.; Patarroyo, M. (2004). An endothelial laminin isoform, laminin 8 (alpha 4 beta 1 gamma 1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis. Blood, 104 (6), 1859−1866.
1.1.
2003
Yan, FX.; Langub, MC.; Ihnen, MA.; Hornung, C.; Juronen, E.; Rayens, MK.; Cai, WM.; Wedlund, PJ.; Fanti, P. (2003). CYP2D6, GST-M1 and GST-T1 enzymes: expression in parathyroid gland and association with the parathyroid hormone concentration during early renal replacement therapy. British Journal of Clinical Pharmacology, 56 (1), 68−77.
1.1.
2003
Veromann, S.; Sunter, A.; Tasa, G.; Juronen, E.; Panov, A.; Pastak, M.; Kaljurand, K. (2003). Dietary sugar and salt represent real risk factors for cataract development. Ophthalmologica, 217 (4), 302−307.
1.1.
2002
Alexandrie, AK.; Rannug, A.; Juronen, E.; Tasa, G.; Warholm, M. (2002). Detection and characterization of a novel functional polymorphism in the GSTT1 gene. Pharmacogenetics, 12 (8), 613−619.
5.2.
2002
Veromann, S.; Sünter, A.; Juronen, E.; Tasa, G.; Panov, A.; Pastak, M.; Kaljurand, K. (2002). Kuidas tekitada katarakti ehk miks peaks vältima suhkrurikast ja soolast toitu? Eesti Arst, 81 (8), 473−477.
1.1.
2001
Tasa, G.; Kals, J.; Muru, K.; Juronen, E.; Piirsoo, A.; Veromann, S.; Janes, S.; Mikelsaar, AV.; Lang, A. (2001). A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. Investigative Ophtalmology & Visual Science, 42 (12), 2762−2764.
1.1.
2000
Juronen, E.; Tasa, T.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. Investigative Ophtalmology & Visual Science, 41 (8), 2262−2267.
1.1.
2000
Juronen, E.; Tasa, G.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. Experimental Eye Research, 71 (5), 447−452.
1.3.
2000
Veromann, S.; Tasa, G.; Viikmaa, M.; Juronen, E.; Tiidla, A.; Paju, K.; Jüri, P.; Pulges, R.; Panov, A.; Koka, K.; Soovere, L. (2000). Vanaduskatarakti riskifaktori - perekondliku eelsoodumuse etioloogiline analüüs. Originaalandmetega ülevaade. Eesti Arst, 79 (5), 272−279.
5.1.
2000
Must, A.; Tasa, G.; Kreegipuu, K.; Muru, K.; Juronen, E.; Allik, J.; Lang, A. (2000). Association of personality patterns with genetic markers of the serotonergic system. American Journal of Medical Genetics, 96 (4), 510−510.
1.1.
1999
Kurg, R.; Parik, J.; Juronen, E.; Sedman, T.; Abroi, A.; Liiv, I.; Langel, U.; Ustav, M. (1999). Effect of bovine papillomavirus E2 protein-specific monoclonal antibodies on papillomavirus DNA replication. Journal of Virology, 73 (6), 4670−4677.
1.1.
1997
Veitch, JM.; Murray, GI.; Juronen, E.; Kilty, CG.; Doyle, S.; Hawksworth, GM.; Rodilla, V. (1997). Theta-class glutathione S-transferases in human kidney and renal tumours. Biochemical Society Transactions, 25 (4), S605−S605.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochemistry and Molecular Biology International, 39 (1), 21−29.
1.1.
1996
Tasa, G.; Juronen, E.; Viikmaa, M.; Tiidla, A.; Parlist, P.; Uuskula, M.; Kalev, I.; Mikelsaar, AV. (1996). Distribution of glutathione S-transferase T1 phenotypes in the Estonian population. Gene Geography, 10 (3), 181−189.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Production and characterization of monoclonal antibodies against class theta glutathione S-transferase T1-1. Hybridoma, 15 (1), 77−82.
1.1.
1995
Tasa, G.; Juronen, E.; Uuskula, M.; Viikmaa, M.; Mikelsaar, AV. (1995). Phenotyping of glutathione-s-transferase m1 in the Estonian population by elisa using gstm1a and gstm1b specific monoclonal-antibodies. Clinica Chimica Acta, 239 (2), 191−196.
1.1.
1994
Juronen, E.; Tasa, G.; Uuskula, M.; Parik, J.; Mikelsaar, AV. (1994). Allele-specific monoclonal-antibodies against glutathione-s-transferase mu1-1. Hybridoma, 13 (6), 477−484.
1.1.
1994
Veromann, S.; Sikut, R.; Juronen, E. (1994). No immunoglobulins in cataractous lenses. Ophthalmic Research, 26 (5), 261−263.
1.1.
1991
Juronen, E.; Parik, J.; Toomik, P. (1991). Fplc purification of mouse monoclonal-antibodies from ascitic fluid using blue deae and thiophilic sorbents. Journal of Immunological Methods, 136 (1), 103−109.
1.1.
1989
Toropova, BG.; Glebov, AV.; Okulov, VB.; Yuronen, EI.; Mikelsaar, AVN. (1989). Factors influencing the human blood-serum myoglobin levels measured by enzyme-immunoassay. Laboratornoe Delo, 12, 54−55.
1.1.
1989
Lepner, UR.; Yuronen, EI.; Tamm, VY. (1989). Myoglobin levels in patients with obliterating diseases of the lower-extremities. Kardiologiia, 29 (4), 83−86.
1.1.
1988
Juronen, EI.; Viikmaa, MH.; Mikelsaar, AVN. (1988). Rapid, simple and sensitive antigen capture elisa for the quantitation of myoglobin using monoclonal-antibodies. Journal of Immunological Methods, 111 (1), 109−115.
1.1.
1988
Yuronen, EI.; Viykman, MG.; Mikelsaar, AVN. (1988). Use of monoclonal-antibodies for quantitative estimation of myoglobin by means of solid-phase immunoenzyme sandwich assay. Voprosy Meditsinskoi Khimii, 34 (4), 132−136.
5.1.
1984
Piirsoo, AO.; Yuronen, EI.; Parik, YY.; Khaldre, SY.; Mikelsaar, AN.; Viikmaa, MG.; Krinka, A. (1984). Hybridomes producing monoclonal-antibodies for myoglobins and isoenzymes of human bb-creatinephosphokinase. Tsitologiya, 26 (9), 1077−1077.

Tööstusomand

10.03.2020

Erkki Juronen

https://www.etis.ee/CV/Erkki_Juronen/eng
24.02.1959
737 4217
erkki.juronen@ut.ee

Career

Institutions and positions
01.01.2014–...   
cosagen Cell Factory OÜ, senior researcher (1,00)
01.01.2015–31.12.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Research Fellow in Immunogenetics and Immunochemistry (0,25)
01.04.2014–31.12.2014   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Research Fellow in Immunogenetics and Immunochemistry (0,75)
26.08.2013–31.03.2014   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Research Fellow in Immunogenetics and Immunochemistry (1,00)
21.05.2013–25.08.2013   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Senior Research Fellow in Immunogenetics and Immunochemistry (1,00)
26.08.2008–20.05.2013   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Senior Research Fellow in Immunogenetics and Immunochemistry (1,00)
27.08.2003–25.08.2008   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Senior Research Fellow (1,00)
1993–2013   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Senior Researcher (1,00)
01.01.1988–31.12.1993   
University of Tartu, Faculty of Medicine, Department of General and Molecular Pathology; head of Laboratory of Immunoanalysis
01.01.1986–31.12.1988   
University of Tartu, postgraduate student in molecular biology
01.01.1982–31.12.1986   
University of Tartu, Faculty of Medicine, Department of General and Molecular Pathology; junior scientist
 
 
Education
1977–1982   
University of Tartu, Department of Biology, ichtyologist-hydrobiologist
 
 
Additional information
Estonian Science Foundation grants:
1) Grant 1358: Examination of glutathione S-transferase Theta polymorphism (1995-1996);
2) Grant 3020: The role of polymorphic detoxifying enzymes in formation of eye diseases in Estonians (1997-1998);
3) Grant 4349: Polymorphic glutathione S-transferases GSTM3, GSTP1 and GSTZ1 in Estonians and possible connections with susceptibility to diseases (2000-2003).
4) Grant 8981: Membrane-bound mucins as target molecules for cancer immunotherapy and diagnostics (2012-2015).
Agreement no. 11160-290910 between University of Tartu and Millipore Inc about production and distribution of monoclonal antibodies to laminin chains.
Principal investigator of the project SF0180096s08 "Differentiation of human fetal neural and embryonic stem cells to neural cell lineages and development of new immunomarkers" (2008-2013)

Qualifications

Academic degrees
Erkki Juronen, Doctor's Degree, 1988, (sup) Aavo-Valdur Mikelsaar, Моноклоналъные антитела к миоглобину человека (Monoclonal antibodies against human myoglobin), University of Tartu, Faculty of Medicine.
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.1. Biomedicine; SPECIFICATION: Monoclonal antibodies in genetic and stem cell research
 
 

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2014
Pook, M.; Tamming, L.; Padari, K.; Tiido, T.; Maimets, T.; Patarroyo, M.; Juronen, E.; Jaks, V.; Ingerpuu, S. (2014). Platelets store laminins 411/421 and 511/521 in compartments distinct from α- or dense granules and secrete these proteins via microvesicles. Journal of Thrombosis and Haemostasis, 12 (4), 519−527.10.1111/jth.12513.
5.2.
2014
Mikelsaar, A-V.; Vorobjova, A.; Saag, M.; Mikelsaar, Ruth; Juronen, E. (2014). Expression of mucins and glutathione-S-transferases in dental stem cells isolated from human third molar. Cytochemical study. Abstract of the 12th Annual Meeting of ISSCR (International Society for Stem Cell Research), Vancouver(Canada), 2014. F-L-4021.
1.1.
2013
Celojevic, D.; Nilsson, S.; Behndig, A.; Tasa, G.; Juronen, E., Karlsson, J.O.; Zetterberg, H.; Petersen, A.; Zetterberg, M. (2013). Superoxide Dismutase Gene Polymorphisms in Patients with Age-related Cataract. Ophthalmic Genetics, 34 (3), 140−145.10.3109/13816810.2012.746377.
1.1.
2013
Kärner, J.; Meager, A.; Laan, M.; Maslovskaja, J.; Pihlap, M.; Remm, A.; Juronen, E.; Wolff, A. S. B.; Husebye, E. S.; Podkrajšek, K. T.; Bratanic, N.; Battelino, T.; Willcox, N.; Peterson, P.; Kisand, K. (2013). Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice. Clinical and Experimental Immunology, 171 (3), 263−272.10.1111/cei.12024.
1.1.
2013
Wondimu, Z; Omrani, S; Ishikawa, T; Javed, F; Oikawa, Y; Virtanen, I; Juronen, E; Ingerpuu, S; Patarroyo, M (2013). A Novel Monoclonal Antibody to Human Laminin a5 Chain Strongly Inhibits Integrin-Mediated Cell Adhesion and Migration on Laminins 511 and 521. PLoS ONE, 8 (1), 1−11.10.1371/journal.pone.0053648.
5.2.
2013
Ustinova, Julia; Belitskin, Denis; Juronen, Erkki; Zusinaite, Eva; Utt, Meeme; Uibo, Raivo (2013). Characterization of monoclonal ZnT8-specific antibody. 15th International Congress of Immunology (ICI); Milan, Italy; 22 Aug - 27 Aug, 2013. DOI: 10.3389/conf.fimmu.2013.02.00326.
5.2.
2013
Mikelsaar, A.-V.; Masso, R.; Masso, M.; Sünter, A.; Mikelsaar, R.; Juronen, E. (2013). Titiin mittelihasrakkudes. Evolutsiooniline analüüs. Eesti Arst, 92. 37−37. (Lisa 2).
1.1.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, R.; Toomik, P.; Kõiveer, A.; Mikelsaar, I.; Juronen, E. (2012). Epitope of titin a-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells. Cell Division, 7, Art No 21.10.1186/1747-1028-7-21.
3.2.
2012
Mikelsaar Aavo-Valdur, Sünter Alar, Toomik Peeter, Karpson Kalmer, Juronen Erkki (2012). Development of new monoclonal antibodies for immunocytochemical characterization of neural stem and differentiated cells. In: Tao Sun (Ed.). Neural Stem Cells (93−118).. University Campus, STeP Ri Slavka Krautzeka 83/A 51000 Rijeka, Croatia: INTECH Open Access Publisher.
5.2.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, Ruth; Toomik, P.; Mikelsaar, I.; Juronen, E. (2012). Evolutionary aspects of centriole associated proteins. Europ J Human Genetics: European Human Genetics Conference 2012 in conj. with the European Meeting on Psychosocial Aspects of Genetics, Nürnberg. 251.
1.1.
2011
Rudolph, T.; Sjölander, A.; Palmér, M.S.; Minthon, L.; Wallin, A.; Andreasen, N.; Tasa, G.; Juronen, E.; Blennow, K.; Zetterberg, H.; Zetterberg, M. (2011). Ubiquitin Carboxyl-Terminal Esterase L1 (UCHL1) S18Y Polymorphism In Patients With Cataracts. Ophthalmic Genetics, 32 (2), 75−79.
3.1.
2011
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter; Mikelsaar, Ruth; Juronen, Erkki (2011). New data on the centrosome proteins. Chromosome Research. The Biology of Chromatin and Chromosomes, 19: 8th European Cytogenetics Conference, Altândega Congress & Exhibition Centre, Portugal, 2-5. july 2011. Springer, S199. (Supplement 1).
1.1.
2010
Mikelsaar, A-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Kalev, I.; Kõiveer, A.; Piirsoo, A.; Karpson, K.; Juronen, E. (2010). Titin A-band-specific Monoclonal Antibody Tit1 5H1.1. Cellular Titin As a Centriolar Protein in Non-muscle Cells. Hybridoma, 29 (5), 391−401.
1.1.
2010
Faustova, Ilona; Kuznetsov, Aleksei; Juronen, Erkki; Loog, Mart; Järv, Jaak (2010). Phosphorylation is switch of L-type pyruvate kinase allostery. Central European Journal of Biology, 5, 135−142.10.2478/s11535-010-0004-6.
5.2.
2010
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Juronen, E. (2010). Titin or a titin-like protein as a human centriolar protein? European Journal of Human Genetics, Supplement 1: European Human Genetics Conference 2010 in conjuction with European Meeting on Psychosocial Aspects of Genetics. Swedish Exhibition & Converence Centre: Nature Publishing Group, 109. (18).
1.1.
2009
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K.; Juronen, E. (2009). New Anti-Ku80 Monoclonal Antibody F10H2.B3 As a Useful Marker for Dividing Cells in Culture. Hybridoma, 107−111. DOI: 10.1089/hyb.2008.0077.
5.1.
2009
Mikelsaar, A.-V. ; Sünter, A.; Toomik, P.; Karpson, K. ; Mikelsaar, R.; Juronen, E.. (2009). The subcellular localisation of Ku80 during mitotic cycle - an immunocytochemical analysis using anti Ku80 Mab F10H2.B3. Chromosome Research, 17: 7th European Cytogenetics Conference, Stockholm, 4-7 July 2009. Ed. Herbert Macgregor. Dordrecht, The Netherlands/Norwel,MA,USA: Springer Heidelberg, S172−S172.
5.2.
2009
Orlova , Svetlana; Kõiveer, Anu; Juronen, Erkki; Piirsoo, Andres (2009). NEURAL DIFFERENTIATION OF HUMAN ES CELLS H9.2 AND I4 DERIVED EMBRYOID BODIES INDUCED BY RETINOIC ACID ON BD MATRIGEL. In: Abstracts of ISSCR 7th Annual Meeting (108).International Society for Stem Cell Research: ISSCR 7th Annual meeting; Barcelona, Spain; July 8-11, 2009. Barcelona , Spain 2009.
1.1.
2008
Nikonov, A.; Juronen, E.; Ustav, M. (2008). Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase. Journal of Biological Chemistry, 283 (35), 24089−24102. DOI: 10.1074/jbc.M803422200.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1783 (1), 74−83. DOI: 10.1016/j.bbamcr.2007.09.003.
1.1.
2007
Andersson, M.E.; Zetterberg, M.; Tasa, G.; Seibt-Palmér, M.; Juronen, E.; Teesalu, P.; Blennow, K.; Zetterberg, H. (2007). Variability in the kinesin light chain 1 gene may influence risk of age-related cataract. Molecular Vision, 13, 993−996.
1.1.
2007
Zetterberg, M.; Tasa, G.; Palmér, M.S.; Juronen, E.; Toover, E.; Blennow, K.; Zetterberg, H. (2007). Methylenetetrahydrofolate reductase genetic polymorphisms in patients with primary open-angle glaucoma. Ophthalmic Genetics, 28 (2), 47−50.
1.1.
2007
Zetterberg, M.; Tasa, G.; Palmér, M.S.; Juronen, E.; Teesalu, P.; Blennow, K.; Zetterberg, H. (2007). Apolipoprotein E polymorphisms in patients with primary open-angle glaucoma. American Journal of Ophthalmology, 143 (6), 1059−1060.
1.1.
2005
Zetterberg, M.; Tasa, G.; Prince, JA.; Palmer, M.; Juronen, E.; Veromann, S.; Teesalu, P.; Karlsson, JO.; Blennow, K.; Zetterberg, H. (2005). Methylenetetrahydrofolate reductase genetic polymorphisms in patients with cataract. American Journal of Ophthalmology, 140 (5), 932−934.
1.1.
2004
Veromann, S.; Sunter, A.; Juronen, E.; Tasa, G.; Panov, A. (2004). Eye lens crystallins: A component of intraocular pseudoexfoliative material. Ophthalmic Research, 36 (1), 51−54.
1.1.
2004
Zetterberg, M.; Zetterberg, H.; Palmer, M.; Rymo, L.; Blennow, K.; Tasa, G.; Juronen, E.; Veromann, S.; Teesalu, P.; Zetterberg, M.; Karlsson, JO.; Hoglund, K. (2004). Apolipoprotein E polymorphism in patients with cataract. British Journal of Ophthalmology, 88 (5), 716−718.
1.1.
2004
Wondimu, Z.; Geberhiwot, T.; Ingerpuu, S.; Juronen, E.; Xie, X.; Lindbom, L.; Doi, M.; Kortesmaa, J.; Thyboll, J.; Tryggvason, K.; Fadeel, B.; Patarroyo, M. (2004). An endothelial laminin isoform, laminin 8 (alpha 4 beta 1 gamma 1), is secreted by blood neutrophils, promotes neutrophil migration and extravasation, and protects neutrophils from apoptosis. Blood, 104 (6), 1859−1866.
1.1.
2003
Yan, FX.; Langub, MC.; Ihnen, MA.; Hornung, C.; Juronen, E.; Rayens, MK.; Cai, WM.; Wedlund, PJ.; Fanti, P. (2003). CYP2D6, GST-M1 and GST-T1 enzymes: expression in parathyroid gland and association with the parathyroid hormone concentration during early renal replacement therapy. British Journal of Clinical Pharmacology, 56 (1), 68−77.
1.1.
2003
Veromann, S.; Sunter, A.; Tasa, G.; Juronen, E.; Panov, A.; Pastak, M.; Kaljurand, K. (2003). Dietary sugar and salt represent real risk factors for cataract development. Ophthalmologica, 217 (4), 302−307.
1.1.
2002
Alexandrie, AK.; Rannug, A.; Juronen, E.; Tasa, G.; Warholm, M. (2002). Detection and characterization of a novel functional polymorphism in the GSTT1 gene. Pharmacogenetics, 12 (8), 613−619.
5.2.
2002
Veromann, S.; Sünter, A.; Juronen, E.; Tasa, G.; Panov, A.; Pastak, M.; Kaljurand, K. (2002). Kuidas tekitada katarakti ehk miks peaks vältima suhkrurikast ja soolast toitu? Eesti Arst, 81 (8), 473−477.
1.1.
2001
Tasa, G.; Kals, J.; Muru, K.; Juronen, E.; Piirsoo, A.; Veromann, S.; Janes, S.; Mikelsaar, AV.; Lang, A. (2001). A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. Investigative Ophtalmology & Visual Science, 42 (12), 2762−2764.
1.1.
2000
Juronen, E.; Tasa, T.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. Investigative Ophtalmology & Visual Science, 41 (8), 2262−2267.
1.1.
2000
Juronen, E.; Tasa, G.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. Experimental Eye Research, 71 (5), 447−452.
1.3.
2000
Veromann, S.; Tasa, G.; Viikmaa, M.; Juronen, E.; Tiidla, A.; Paju, K.; Jüri, P.; Pulges, R.; Panov, A.; Koka, K.; Soovere, L. (2000). Vanaduskatarakti riskifaktori - perekondliku eelsoodumuse etioloogiline analüüs. Originaalandmetega ülevaade. Eesti Arst, 79 (5), 272−279.
5.1.
2000
Must, A.; Tasa, G.; Kreegipuu, K.; Muru, K.; Juronen, E.; Allik, J.; Lang, A. (2000). Association of personality patterns with genetic markers of the serotonergic system. American Journal of Medical Genetics, 96 (4), 510−510.
1.1.
1999
Kurg, R.; Parik, J.; Juronen, E.; Sedman, T.; Abroi, A.; Liiv, I.; Langel, U.; Ustav, M. (1999). Effect of bovine papillomavirus E2 protein-specific monoclonal antibodies on papillomavirus DNA replication. Journal of Virology, 73 (6), 4670−4677.
1.1.
1997
Veitch, JM.; Murray, GI.; Juronen, E.; Kilty, CG.; Doyle, S.; Hawksworth, GM.; Rodilla, V. (1997). Theta-class glutathione S-transferases in human kidney and renal tumours. Biochemical Society Transactions, 25 (4), S605−S605.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochemistry and Molecular Biology International, 39 (1), 21−29.
1.1.
1996
Tasa, G.; Juronen, E.; Viikmaa, M.; Tiidla, A.; Parlist, P.; Uuskula, M.; Kalev, I.; Mikelsaar, AV. (1996). Distribution of glutathione S-transferase T1 phenotypes in the Estonian population. Gene Geography, 10 (3), 181−189.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Production and characterization of monoclonal antibodies against class theta glutathione S-transferase T1-1. Hybridoma, 15 (1), 77−82.
1.1.
1995
Tasa, G.; Juronen, E.; Uuskula, M.; Viikmaa, M.; Mikelsaar, AV. (1995). Phenotyping of glutathione-s-transferase m1 in the Estonian population by elisa using gstm1a and gstm1b specific monoclonal-antibodies. Clinica Chimica Acta, 239 (2), 191−196.
1.1.
1994
Juronen, E.; Tasa, G.; Uuskula, M.; Parik, J.; Mikelsaar, AV. (1994). Allele-specific monoclonal-antibodies against glutathione-s-transferase mu1-1. Hybridoma, 13 (6), 477−484.
1.1.
1994
Veromann, S.; Sikut, R.; Juronen, E. (1994). No immunoglobulins in cataractous lenses. Ophthalmic Research, 26 (5), 261−263.
1.1.
1991
Juronen, E.; Parik, J.; Toomik, P. (1991). Fplc purification of mouse monoclonal-antibodies from ascitic fluid using blue deae and thiophilic sorbents. Journal of Immunological Methods, 136 (1), 103−109.
1.1.
1989
Toropova, BG.; Glebov, AV.; Okulov, VB.; Yuronen, EI.; Mikelsaar, AVN. (1989). Factors influencing the human blood-serum myoglobin levels measured by enzyme-immunoassay. Laboratornoe Delo, 12, 54−55.
1.1.
1989
Lepner, UR.; Yuronen, EI.; Tamm, VY. (1989). Myoglobin levels in patients with obliterating diseases of the lower-extremities. Kardiologiia, 29 (4), 83−86.
1.1.
1988
Juronen, EI.; Viikmaa, MH.; Mikelsaar, AVN. (1988). Rapid, simple and sensitive antigen capture elisa for the quantitation of myoglobin using monoclonal-antibodies. Journal of Immunological Methods, 111 (1), 109−115.
1.1.
1988
Yuronen, EI.; Viykman, MG.; Mikelsaar, AVN. (1988). Use of monoclonal-antibodies for quantitative estimation of myoglobin by means of solid-phase immunoenzyme sandwich assay. Voprosy Meditsinskoi Khimii, 34 (4), 132−136.
5.1.
1984
Piirsoo, AO.; Yuronen, EI.; Parik, YY.; Khaldre, SY.; Mikelsaar, AN.; Viikmaa, MG.; Krinka, A. (1984). Hybridomes producing monoclonal-antibodies for myoglobins and isoenzymes of human bb-creatinephosphokinase. Tsitologiya, 26 (9), 1077−1077.

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0182560s03Geneetilised ja rakulised haiguste põhjused, rakkude diferentseerumine ja tüvirakud teraapias01.01.200331.12.2007Aavo-Valdur MikelsaarTartu Ülikool, Arstiteaduskond477 675,66 EUR
SFSF0180096s08Inimese fetaalsete neuraalsete ja embrüonaalsete tüvirakkude differentseerumine neuraalses suunas ja uute immuunmarkerite loomine01.01.200831.12.2013Erkki JuronenTartu Ülikool, Arstiteaduskond483 282,82 EUR
ETFETF6589Inimgenoomi DNA järjestuste koopiaarvu varieeruvus ja genoomsed haigused01.01.200631.12.2009Gunnar TasaTartu Ülikool, Arstiteaduskond46 307,83 EUR
MUUSARMP13001T (3.2.0701.12-0049)Interleukiinid psoriaasi diagnostikas01.09.201231.08.2015Pärt PetersonTartu Ülikool289 975,00 EUR
SFSF0180012s11Kõhr- ja luukoe formeerumise ja degeneratsiooni mehhanismid erinevate patoloogiate korral01.01.201131.12.2016Andres ArendTartu Ülikool, Arstiteaduskond402 000,00 EUR
ETFETF8981Membraaniga seotud mutsiinid kui kasvajate immuunoteraapia ja diagnostika sihtmolekulid.01.01.201231.12.2015Erkki JuronenTartu Ülikool, Arstiteaduskond96 000,00 EUR
MUULARMP12232Projekti BOSS (BOVINE SPERM SEXING) raames polü- ja monoklonaalsete antikehade loomine pulli X- ja/või Y-kromosoomi kandvate spermide vastu01.10.201231.12.2014Aavo-Valdur MikelsaarTartu Ülikool; Tartu Ülikool, Arstiteaduskond93 360,00 EUR
ETFETF9103Tsüsteinüülleukotrieenide hingamisteede remodelleerumist soodustava toime retseptorvahendatus inimese hingamisteede epiteelrakkudes 01.01.201231.12.2015Siiri AltrajaTartu Ülikool, Arstiteaduskond86 400,00 EUR
APSF0180096s08APVäikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180096s08 raames01.01.201031.12.2011Erkki JuronenTartu Ülikool, Arstiteaduskond24 286,43 EUR