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9.05.1949
+1 613 804 1885
illimaraltosaar@gmail.com
Illimar ALTOSAAR is Professor of Biochemistry, Microbiology & Immunology at University of Ottawa. He has worked alongside notable scientists such as Sir Ralph Riley (Rockefeller Foundation Rice Biotech Network), Sir Hans Kornberg (Biochemistry Dept., Cambridge), Professor Brian Hartley, F.R.S and Sir Ernst Chain, Nobel Laureate for penicillin fermentation (Imperial College). Together with his family heritage in plant pathology (Erwinia, Fusarium), engineering (textiles, pulp & paper sectors), and his diverse experiences in pharmaceutical and agri-food industries, Prof. Altosaar is deploying gene technology in critical areas such as Milk and Mammary Immunology, Host-Pathogen Interactions, Starch-Protein Interactions, Protein Farming, Molecular Breeding, phytoremediation and greenhouse gas mitigation. He is currently appointed as Visiting Scientist at The Scripps Research Institute’s Department of Chemical Physiology (2013-2014), and has worked at University of New South Wales in Sydney, Australia (2006-07) on engineering anti-bacterial biofilm genes into crop plants, immune milk proteins at Nestlé (2000), cereal storage proteins at Tartu University (1993-95), cereal genetics at Jõgeva Plant Science Institute (1987-present), Estonian University of Life Sciences-EMÜ (2016-present), wheat proteins at INRA France (92-3), bread-making quality at Plant Breeding Institute of University of Cambridge (84-85) and a NATO Fellow in Biochemistry at Imperial College (75-77). ‘Molecular mechanisms’ has been the ethos of Dr. Altosaar’s research efforts since he first began working in cereal genetics in 1966 at the Quebec Provincial Seed Farm, Macdonald College-McGill University (Montreal). A protein chemist by training, he has studied gene regulation in small grains and oilseeds. He has been instrumental in supplying useful gene cassettes to crop breeding programs throughout the world. Plant codon optimized Bacillus thuringiensis sequences for cry 1Ab, cry1Ac, cry1C (40% G:C), cry1C(70% G:C) and cry2Aa2 have been deployed in over 35 various crop species in more than 75 countries. Author of over 178 articles (ISI), some of which have been highly cited (265 times ISI Web of Knowledge, 207 Scopus, >348 Scholar.Google), six patent applications, and one issued US patent. Professor Altosaar has earned a bachelor’s degree in cell biology from McGill University and a doctorate in plant protein biochemistry from University of British Columbia.

Career

Institutions and positions
01.01.2019–...   
Estonian University of Life Sciences, Visiting Professor (0,20)
01.07.2013–...   
The Scripps Research Institute, shotgun proteomics (1,00)
01.07.2005–...   
Estonian Crop Research Institute, Plant Pathology and Plant Biotechnology Department (1,00)
01.06.1978–...   
University of Ottawa, Professor of Food Biochemistry and plant biotechnology (1,00)
01.07.2013–30.06.2014   
University of California San Diego, Visiting Scholar, Center for Marine Biotechnology and Biomedicine (1,00)
01.07.2006–30.06.2007   
The University of New South Wales, Centre for Marine Biofouling and Bio-Innovation (1,00)
01.07.1999–30.06.2000   
Plant Research Center NESTLE Tours France, Plant production of human proteins (1,00)
 
 
Education
01.09.1970–31.12.1974   
Ph.D
 
 
R&D related managerial and administrative work
1966−...   
biochemistry microbiology and immunology research and education
 
 
Creative work
Illimar ALTOSAAR was Professor of Biochemistry, Microbiology & Immunology at University of Ottawa. He has worked alongside notable scientists such as Sir Ralph Riley, Sir Hans Kornberg (Biochemistry Dept., Cambridge), Professor Brian Hartley, F.R.S and Sir Ernst Chain, Nobel Laureate for penicillin fermentation (Imperial College, London, England). Together with his diverse experiences in pharmaceutical and agri-food industries, Prof. Altosaar is practicing systems biology in critical areas such as Milk and Mammary Immunology, and Host-Pathogen Interactions. Currently appointed as Visiting Scientist at The Scripps Research Institute’s Department of Chemical Physiology (2014-15), he has worked at University of New South Wales (2006-07), Nestlé (1999-2000), Tartu University (1993-95), INRA France (92-3), University of Cambridge (84-85) and Imperial College (75-77). ‘Molecular mechanisms’ is the ethos of Dr. Altosaar’s research efforts. Author of over 189 articles (ISI), some of which have been highly cited (294 times ISI, 397 Scholar.Google, h-index 37), seven patent applications, and one issued US patent. Professor Altosaar has earned a bachelor’s degree in cell biology from McGill University and a doctorate in protein biochemistry from University of British Columbia, Vancouver. .
 
 
Additional information
Current Research Grants and Contracts

2020-2025 (pending) Quantitative Proteomics of Amyloplast Starch Granule development in Cereal Endosperm, NSERC Discovery Grant, $131,700 per year, Submitted 110.31.2019.

2020 Expression of Synthetic Silk Protein in Plants for Scalable Production of Fibre Biomaterials, Ontario Genomics Industry Challenge 2020 Program, $50,000 (with two industry partners).

2020-2022 Canadian Institutes of Health Research (CIHR) Rapid Research Response to the 2019 Novel Coronavirus COVID-19 Outbreak: Development of Targeted Diagnostics, Therapeutics and Comparative Pathogenicity Assessment, Total awarded CAD$999,999 (234,000 to IA),
Principal Applicant: Langlois, Marc-Andre.

2019-2022 CIHR Project Grant, Effect of human milk exosomal microRNAs on intestinal cells, 46% of Total $661,726 awarded, PI J-F Beaulieu UdeSherbrooke, Co-applicants I. Altosaar, E. Ferretti.

2018 OAFT Travel Award, University of Ghent spinout AgroSavfe B.V. on Cereal powder production in rice flour of camelid VHH antibodies as antifungal crop sprays, 29 Nov 2018 - 31 January 2019, grant RR2B RB-278 $6000.

2018 OAFT Travel Award, Micron-Hosokawa, Summit, NJ on Design Classification for protein-shifting of rice flour, starch granules, protein bodies, 24-25 Oct, grant RR2B RB-223F $4490.

2018-2021 LIQD-CORNEAl glue-filler as alternative to transplantation in high risk patients: Protein farming of Collagen and antimicrobial KR12 peptide fusions, € 164,076 ($244,971) or 18% Total project €919,449 ($1,371,000) 4-partner consortium Lead PI Dr M Griffith, UdeMontreal, collaborator Dr E. Loit, Estonian University of Life Sciences, 9th Joint Transnational Call for Proposals (JTC) for "European Innovative Research & Technological Development Projects in Nanomedicine" (ERA-NET EuroNanoMed III framework) awarded 19 Oct 2018 for 36 months.

2018-2020 Greenhouse Gas (GHG) Reduction by atmospheric phytoremediation using bacterial Nitrous Oxide Reductase, LOI ID: 140, Technology Validation Stream of the Low Carbon Innovation Fund (LCIF), Ministries of Economic Development, Employment and Growth & Research, Innovation and Science, Ontario $800,000 Invited 12.14.2017; awarded 2.28.2018.
“Optimizing expression of Pseudomonas nautica genes for nitrous oxide reductase in maize to mitigate the most radiative greenhouse gas, nitrous oxide.”

;
Previous Projects, Grants and Contracts

2017-2018 Development of tethering methods for affinity capture chromatography of recombinant proteins: High-level expression of a recombinant active microbial transglutaminase in transgenic rice. PI: I. Altosaar. National Research Council Industrial Research Assistance Program-TIP grant 888671, CND$39,500.
2017.5-2017.12 NSERC Engage "Dairy cow management may benefit from plant nucleic acids - testing microRNAs from milk and meadowgrass wildflower, Heal-All or Selfheal - Prunella vulgaris" $23,000
2017.09-2018.03 Udder Comfort Inc/NSERC Engage "Plant nucleic acids RNAseq - miRNA from Heal-All, Prunella" Partner Supplement $12,550
2015-2017 Rasi Seed Inc., Attur, India Gene optimization of nosZ from Marinobacter hydrocarbonoclasticus for high level expression of nitrous oxide reductase in Oryza sativa, $35,000.00.
2013-2014 Growing Forward 2: Oilseeds East: Market-Driven Research for Soybean and Canola Supply Chain Profitability - Rapid Marker Assisted Back Crossing (MABC) and Speed Breeding. Sevita International Corporation $10,000.
2013-2014 University of Ottawa Sabbatical grant-in-lieu-of salary award, Proteomics of starch granule associated proteins in relation to Bio-energy optimization (Solaromics), 6.30.2013-6.30.2014. Research Bursary 1032786 $40,000.
2012-2016 NSERC IPS2, Expression of recombinant proteins in Algae (Chlamydomonas reinhardtii) using a puroindoline fusion system, for doctoral student support to T Greenham, $25,000 per year for 3 years, $6K/yr from Solarvest Bioenergy (PEI) Inc. NSERC Industrial Innovation Scholarships Program
2012-2017 Growth and Development of The Wheat Starch Granule Associated Proteome During Growth and Development of The Seed, NSERC Discovery Grant 385806-2012/2017, $34,000 per year, $170,000 total, 165769851.
2011-2012 Agri-ome: Proteomics for Global Food Security Monitoring, Proof of Principle award, ORCP-OCE PoP – Ottawa Tech Transfer Network, $10,000.
2011-2012 Agri-omics peptide fingerprinting method using starch granule proteome, Intellectual Ventures Inc (Seattle), $15,000.
2011-2012 Second generation bone morphogenetic protein-2 (BMP2) for dental surgical applications. PI (with HGMP Corp) Accelerate Student 6-month Internship award, MITACS – NCE (UBC), $16,550.
2011-2011 Anhydrous affinity capture purification of recombinant proteins for the production of recombinant CD14 in rice. Co-PI (with D.R. Mack, PI) Accelerate Student 6-month Internship award, MITACS – NCE (York Univ regional office), $16,750.
2010-2013 Eastern Canada Oilseed Development Alliance (ECODA) and “The Developing Innovative Agri-Products Initiative of the Growing Canadian Agri Innovations Program – DIAP”, Agriculture and Agri-Food Canada, partnered with Hendrick Seeds Inc., $20,000.
2010-2011 Development of analytical methods for innovating novel antimicrobial activities and novel formulations for mastitis treatment. PI: I. Altosaar. National Research Council Industrial Research Assistance Program, CND$78,494.40.
2010-2011 Development of tethering methods for affinity capture chromatography of recombinant proteins. PI: I. Altosaar. National Research Council Industrial Research Assistance Program-YES grant PO738929, CND$30,000.
2010-2011 “High throughput screening of cDNA library of Eye Lacrimal Gland for Antimicrobial protein genes using HiTS vital staining method". PI: I Altosaar; Collaborator Dr. Graeme Wistow, NIH Bldg 6/109. National Eye Institute - NIH grant, USD$6,000.00.
2010-2011 Identification and characterization of antimicrobial proteins from the starch granule surface proteome. NSERC Discovery grant, $30,000.
2009-2010 Innovating novel antimicrobial formulations of natural health products for dairy herd health. PI: I. Altosaar. National Research Council Industrial Research Assistance Program grant PO712498, CND$49,979.80.
2005-2011 Identification of regulatory genes in plant nitrogen cycles to reduce N2O production. PI: I Altosaar, Co-applicant: H Kronzucker, U of Toronto. NSERC Green Crop Network, $375,000 over 5 years. This entire GCN Network is funded for $8 Million for 32 PI’s across Canada, ends August 31, 2011.
2007-2011 Fate and function of breast milk and recombinant human CD14 at mammary and newborn gastrointestinal mucosal epithelia. Canadian Institutes of Health Research, Institute of Nutrition Metabolism and Diabetes – CIHR $70,648 p.a. (awarded 26.01.07; applied for 15.09.06) PI Altosaar I (UO); Co-applicants Blais DR (NRC), Mack DR (CHEO). Grant 82816.
2010-2013 Development of Transgenic Maize for Insect Resistance (Böceklere Dayanıklı Transgenik Mısır Bitkilerinin Geliştirilmesi). Supported by TUBITAK, Project No: TOVAK-109O664, Budget: USD$135,000 US; PI: S. Gulbitti-Onarici, Co-PI: I. Altosaar, S. Ozcan.
2009-2014 FPS Domain under OC 2009-1 “Biosafety of forest transgenic trees: improving the scientific basis for safe tree development and implementation of EU policy directives” (OC 2009-1-4625); C. Vettori, PI with Co-applicant IA and 18 others.
2009-2010 NSERC Equipment Special Award, “A liquid scintillation counter for biomedical research” $44,556.00; with two other co-applicants J Baenziger, E Brown.
2006-2008 Pseudomonas aeruginosa and nitrous oxide reductase for bioremediation. Co-PIs Prof A Sayari (Chem), I Altosaar (BMI) Natural Resources Canada $140 000.
2006-2008 Enriching foods with more sequestered iodine: engineering human Sodium-iodine symporter gene into amylase-rich crop plants in Africa. Agence universitaire de la francophonie, AUF $5,669.04 to host Prof. Ibrahim Taga, Biochemistry Dept., University of Douala, Cameroon.
2006-2008 Synthesis of insect resistance genes for crop improvement. The Rockefeller Foundation, Food Security Program Grant 2006 FS 028. US$100,000 over 2 years (ends June 30, 2008).
2004-2007 “Cytogenetic and gene organization studies on potential diabetogenic globulin genes in wheat” Monsanto Canada Inc., $34 210 p.a.
2003-2006 Gallus gallus Genomics: Cracking the chicken genome for anti-Salmonella genes (Enhancing food safety of the table egg: understanding and augmenting antibacterial activity in the eggshell and egg white). Hincke MT (PI, UoO), Altosaar I, McKee MD (McGill), Mine Y (Guelph), Nys Y (SRA Nouzilly FR). NSERC Collaborative Research Opportunities (CRO) grant, $445 000.
2005-2010 Starch granule membrane lipid transfer protein as piggyback carrier of molecular pharming production of recombinant proteins. PI: I Altosaar, Co-applicant: M. Tanchak, Univ Cape Breton, Sydney. NSERC Discovery grant, $28,000 p.a. over 5 years.
2002-2005 Rockefeller Foundation Food Security Program grant "Enhancing Yields in African Crops" - US$300 000.
2003-2004 ACCC PTP Fellowship grant “Comparative Bioethics in Estonia, pre- and post-EU Membership” $10,000.
2001-02 Rockefeller Foundation Food Security Program, Enhancing Yields in Crops" - US$70 000.
2000-2003 Rockefeller Foundation International Program in Rice Genetic Engineering RF 97001 #556 for Breeding, Safety Evaluation and Insect Resistance Management Sustainable Use of Bt Rice, US$80,000 p.a. with Qingyao Shu, Yingwu Xia (PI), Zhejiang Agricultural University, & Mingwei Gao, Institute of Nuclear Agricultural Science, ZAU, Hangzhou, China.
2002-2005 NSERC Research Grant #18022 "Molecular characterization of tryptophanin genes from cereals: a potential source of plant-derived antimicrobial peptides" $96 000. *with Tanchak, M.A., Cape Breton University, Sydney, Nova Scotia.
1991-2000 Rockefeller Foundation Rice Biotechnology Program grant "Genetic modification of starch and starch related enzymes in genetically engineered rice" - US$550 000.
1998-2000 Rockefeller Foundation Support Grant "Insect control technology in transgenic food crops: Postdoc Fellowship awardee Dr. N. Muthukrishnan" $34000.
1998-2001 Monsanto USA "Field trial evaluation in China of CryIA(b) and (c) gene stability in transgenic cereals, Oryza sativa." - US$144,000.
1998-2001 Innovation Foundation of Estonia -Collaborative Grant "Map-based cloning of dwarfing genes in rye" - $250,000. *with Truve, E., Tallinn Technical University.
1999-2002 National Biotechnology Strategy, HC LCDC (with Dr. A. Andonov (PI), R Peeling, L Robert) "Development of plant-based edible vaccines: Genetically altered plant foods to produce and deliver edible vaccines, Hepatitis & Chlamydia" - $140 000.
1996-99 Genentech, Inc. grant "Expression of recombinant human proteins in corn endosperm cells" -US$70 000.
1995-98 Hospital for Sick Children Foundation Grant #XG 95-002 "Development of subunit vaccines against cytomegalovirus: Production in transgenic plants" -$121 018 (with E Tackaberry).
1995-98 Bayer Inc./Red Cross contract #9511 "Evaluation of seed specific plant genetic expression systems for production of blood proteins" -$38 000 (with P Ganz).
1991-98 Ont. Min. Education. URIF contract "Biotechnology approaches (DNA probes- Anti-sense RNA therapeutics) for solving the pre-harvest sprouting problem in cereals" - $750 000.
1997-98 Health Canada, Virology Laboratories, LCDC collaborative contract "Transgenic grain as oral vaccine for Hepatitis A" - $14 000 (with A Andonov, M Callaghan).
;
Estonian scientist active in Estonian SSR 1985 - 1991, and active in Estonian scientific research 1991 - present.;

Qualifications

 
 
Honours & awards
2005, Illimar Altosaar, Head, Pathology and Biotechnology Laboratory, Jõgeva Plant Breeding Institute, Estonia (held concurrently) 2005 – present.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry; CERCS CLASSIFICATION: P310 Proteins, enzymology ; SPECIFICATION: Protein bio-pharming
 
 
Additional information
Founder and CEO of startup Proteins Easy Corp.

Supervision of postdoctoral researchers

  • 05.06.2018−...    Jordan Jonquil Demone  "Soil microbe gene expression of nitrous oxide reductase, nosZ, in Pseudomonas nautica" (University of Ottawa)

Publications

Category
Year
Publication
 
1.1.
2018
1.1.
2018
5.1.
2018
1.1.
2017
5.1.
2017
1.1.
2016
1.1.
2014
1.1.
2014
1.1.
2014
1.1.
2013
1.1.
2013
1.1.
2013
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.1.
2012
1.2.
2012
6.7.
2012
6.7.
2012
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2010
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2009
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2008
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2007
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
1.1.
2006
5.1.
2006
1.1.
2005
1.1.
2005
1.1.
2005
5.1.
2005
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2003
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2002
1.1.
2001
1.1.
2001
5.1.
2001
1.1.
2000
1.1.
2000
1.1.
2000
1.1.
2000
3.1.
2000
1.1.
1999
1.1.
1998
1.1.
1998
3.1.
1997
1.1.
1996
1.1.
1995
1.1.
1994
1.1.
1993
1.1.
1992
1.1.
1992
3.1.
1992
1.1.
1991
1.1.
1991
1.1.
1991
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1989
1.1.
1989
1.1.
1988
1.1.
1988
1.1.
1988
1.1.
1988
1.1.
1988
1.1.
1987
1.1.
1987
1.1.
1987
5.1.
1987
5.1.
1987
5.1.
1987
1.1.
1986
5.1.
1986
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1985
1.1.
1984
1.1.
1984
1.1.
1984
1.1.
1984
1.1.
1984
1.1.
1984
1.1.
1984
1.1.
1984
1.1.
1984
5.1.
1984
1.1.
1983
1.1.
1983
1.1.
1983
1.1.
1983
1.1.
1983
1.1.
1983
1.1.
1983
1.1.
1983
1.1.
1983
5.1.
1983
5.1.
1983
1.1.
1982
1.1.
1982
1.1.
1982
1.1.
1982
5.1.
1982
5.1.
1982
6.7.
1980
2.04.2020
9.05.1949
+1 613 804 1885
illimaraltosaar@gmail.com
biokeemik, ülikooli õpejõud, taimeteadlane, sordiaretaja, biotehnoloog, ärimees, botaanik, valkude keemik,

Teenistuskäik

Töökohad ja ametid
01.01.2019–...   
Eesti Maaülikool, Külalisprofessor (0,20)
01.07.2013–...   
The Scripps Research Institute, Valkude proteomika, mass spektromeetria, Department of Chemical Physiology (1,00)
01.07.2005–...   
Eesti Taimekasvatuse Instituut, Taime patoloogia ja biotehnoloogia osakonna külalisdotsent (1,00)
01.06.1978–...   
University of Ottawa, biokeemik (1,00)
01.07.2013–30.06.2014   
University of California San Diego, Kylalis 6pej6ud, okeani biotehnoloogia biomeditsiin (1,00)
01.07.2006–30.06.2007   
The University of New South Wales, mikrobioloogia (1,00)
01.07.1999–30.06.2000   
Plant Research Center NESTLE, Taime biokeemik ja valkude ekspresioon (1,00)
 
 
Haridustee
01.09.1970–31.12.1974   
Doktorantuur
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
1966−...   
biokeemia uurimistöö
 
 
Loometöö
uurija teadlane bioloog leijutaja genetiline insineer, valkude tootja ja valkude eraldaja.
 
 
Lisainfo
Current Research Grants and Contracts

2020-2025 (pending) Quantitative Proteomics of Amyloplast Starch Granule development in Cereal Endosperm, NSERC Discovery Grant, $131,700 per year, Submitted 110.31.2019.

2020 Expression of Synthetic Silk Protein in Plants for Scalable Production of Fibre Biomaterials, Ontario Genomics Industry Challenge 2020 Program, $50,000 (with two industry partners).

2020-2022 Canadian Institutes of Health Research (CIHR) Rapid Research Response to the 2019 Novel Coronavirus COVID-19 Outbreak: Development of Targeted Diagnostics, Therapeutics and Comparative Pathogenicity Assessment, Total awarded CAD$999,999 (234,000 to IA),
Principal Applicant: Langlois, Marc-Andre.

2019-2022 CIHR Project Grant, Effect of human milk exosomal microRNAs on intestinal cells, 46% of Total $661,726 awarded, PI J-F Beaulieu UdeSherbrooke, Co-applicants I. Altosaar, E. Ferretti.

2018 OAFT Travel Award, University of Ghent spinout AgroSavfe B.V. on Cereal powder production in rice flour of camelid VHH antibodies as antifungal crop sprays, 29 Nov 2018 - 31 January 2019, grant RR2B RB-278 $6000.

2018 OAFT Travel Award, Micron-Hosokawa, Summit, NJ on Design Classification for protein-shifting of rice flour, starch granules, protein bodies, 24-25 Oct, grant RR2B RB-223F $4490.

2018-2021 LIQD-CORNEAl glue-filler as alternative to transplantation in high risk patients: Protein farming of Collagen and antimicrobial KR12 peptide fusions, € 164,076 ($244,971) or 18% Total project €919,449 ($1,371,000) 4-partner consortium Lead PI Dr M Griffith, UdeMontreal, collaborator Dr E. Loit, Estonian University of Life Sciences, 9th Joint Transnational Call for Proposals (JTC) for "European Innovative Research & Technological Development Projects in Nanomedicine" (ERA-NET EuroNanoMed III framework) awarded 19 Oct 2018 for 36 months.

2018-2020 Greenhouse Gas (GHG) Reduction by atmospheric phytoremediation using bacterial Nitrous Oxide Reductase, LOI ID: 140, Technology Validation Stream of the Low Carbon Innovation Fund (LCIF), Ministries of Economic Development, Employment and Growth & Research, Innovation and Science, Ontario $800,000 Invited 12.14.2017; awarded 2.28.2018.
“Optimizing expression of Pseudomonas nautica genes for nitrous oxide reductase in maize to mitigate the most radiative greenhouse gas, nitrous oxide.”

;
Previous Projects, Grants and Contracts

2017-2018 Development of tethering methods for affinity capture chromatography of recombinant proteins: High-level expression of a recombinant active microbial transglutaminase in transgenic rice. PI: I. Altosaar. National Research Council Industrial Research Assistance Program-TIP grant 888671, CND$39,500.
2017.5-2017.12 NSERC Engage "Dairy cow management may benefit from plant nucleic acids - testing microRNAs from milk and meadowgrass wildflower, Heal-All or Selfheal - Prunella vulgaris" $23,000
2017.09-2018.03 Udder Comfort Inc/NSERC Engage "Plant nucleic acids RNAseq - miRNA from Heal-All, Prunella" Partner Supplement $12,550
2015-2017 Rasi Seed Inc., Attur, India Gene optimization of nosZ from Marinobacter hydrocarbonoclasticus for high level expression of nitrous oxide reductase in Oryza sativa, $35,000.00.
2013-2014 Growing Forward 2: Oilseeds East: Market-Driven Research for Soybean and Canola Supply Chain Profitability - Rapid Marker Assisted Back Crossing (MABC) and Speed Breeding. Sevita International Corporation $10,000.
2013-2014 University of Ottawa Sabbatical grant-in-lieu-of salary award, Proteomics of starch granule associated proteins in relation to Bio-energy optimization (Solaromics), 6.30.2013-6.30.2014. Research Bursary 1032786 $40,000.
2012-2016 NSERC IPS2, Expression of recombinant proteins in Algae (Chlamydomonas reinhardtii) using a puroindoline fusion system, for doctoral student support to T Greenham, $25,000 per year for 3 years, $6K/yr from Solarvest Bioenergy (PEI) Inc. NSERC Industrial Innovation Scholarships Program
2012-2017 Growth and Development of The Wheat Starch Granule Associated Proteome During Growth and Development of The Seed, NSERC Discovery Grant 385806-2012/2017, $34,000 per year, $170,000 total, 165769851.
2011-2012 Agri-ome: Proteomics for Global Food Security Monitoring, Proof of Principle award, ORCP-OCE PoP – Ottawa Tech Transfer Network, $10,000.
2011-2012 Agri-omics peptide fingerprinting method using starch granule proteome, Intellectual Ventures Inc (Seattle), $15,000.
2011-2012 Second generation bone morphogenetic protein-2 (BMP2) for dental surgical applications. PI (with HGMP Corp) Accelerate Student 6-month Internship award, MITACS – NCE (UBC), $16,550.
2011-2011 Anhydrous affinity capture purification of recombinant proteins for the production of recombinant CD14 in rice. Co-PI (with D.R. Mack, PI) Accelerate Student 6-month Internship award, MITACS – NCE (York Univ regional office), $16,750.
2010-2013 Eastern Canada Oilseed Development Alliance (ECODA) and “The Developing Innovative Agri-Products Initiative of the Growing Canadian Agri Innovations Program – DIAP”, Agriculture and Agri-Food Canada, partnered with Hendrick Seeds Inc., $20,000.
2010-2011 Development of analytical methods for innovating novel antimicrobial activities and novel formulations for mastitis treatment. PI: I. Altosaar. National Research Council Industrial Research Assistance Program, CND$78,494.40.
2010-2011 Development of tethering methods for affinity capture chromatography of recombinant proteins. PI: I. Altosaar. National Research Council Industrial Research Assistance Program-YES grant PO738929, CND$30,000.
2010-2011 “High throughput screening of cDNA library of Eye Lacrimal Gland for Antimicrobial protein genes using HiTS vital staining method". PI: I Altosaar; Collaborator Dr. Graeme Wistow, NIH Bldg 6/109. National Eye Institute - NIH grant, USD$6,000.00.
2010-2011 Identification and characterization of antimicrobial proteins from the starch granule surface proteome. NSERC Discovery grant, $30,000.
2009-2010 Innovating novel antimicrobial formulations of natural health products for dairy herd health. PI: I. Altosaar. National Research Council Industrial Research Assistance Program grant PO712498, CND$49,979.80.
2005-2011 Identification of regulatory genes in plant nitrogen cycles to reduce N2O production. PI: I Altosaar, Co-applicant: H Kronzucker, U of Toronto. NSERC Green Crop Network, $375,000 over 5 years. This entire GCN Network is funded for $8 Million for 32 PI’s across Canada, ends August 31, 2011.
2007-2011 Fate and function of breast milk and recombinant human CD14 at mammary and newborn gastrointestinal mucosal epithelia. Canadian Institutes of Health Research, Institute of Nutrition Metabolism and Diabetes – CIHR $70,648 p.a. (awarded 26.01.07; applied for 15.09.06) PI Altosaar I (UO); Co-applicants Blais DR (NRC), Mack DR (CHEO). Grant 82816.
2010-2013 Development of Transgenic Maize for Insect Resistance (Böceklere Dayanıklı Transgenik Mısır Bitkilerinin Geliştirilmesi). Supported by TUBITAK, Project No: TOVAK-109O664, Budget: USD$135,000 US; PI: S. Gulbitti-Onarici, Co-PI: I. Altosaar, S. Ozcan.
2009-2014 FPS Domain under OC 2009-1 “Biosafety of forest transgenic trees: improving the scientific basis for safe tree development and implementation of EU policy directives” (OC 2009-1-4625); C. Vettori, PI with Co-applicant IA and 18 others.
2009-2010 NSERC Equipment Special Award, “A liquid scintillation counter for biomedical research” $44,556.00; with two other co-applicants J Baenziger, E Brown.
2006-2008 Pseudomonas aeruginosa and nitrous oxide reductase for bioremediation. Co-PIs Prof A Sayari (Chem), I Altosaar (BMI) Natural Resources Canada $140 000.
2006-2008 Enriching foods with more sequestered iodine: engineering human Sodium-iodine symporter gene into amylase-rich crop plants in Africa. Agence universitaire de la francophonie, AUF $5,669.04 to host Prof. Ibrahim Taga, Biochemistry Dept., University of Douala, Cameroon.
2006-2008 Synthesis of insect resistance genes for crop improvement. The Rockefeller Foundation, Food Security Program Grant 2006 FS 028. US$100,000 over 2 years (ends June 30, 2008).
2004-2007 “Cytogenetic and gene organization studies on potential diabetogenic globulin genes in wheat” Monsanto Canada Inc., $34 210 p.a.
2003-2006 Gallus gallus Genomics: Cracking the chicken genome for anti-Salmonella genes (Enhancing food safety of the table egg: understanding and augmenting antibacterial activity in the eggshell and egg white). Hincke MT (PI, UoO), Altosaar I, McKee MD (McGill), Mine Y (Guelph), Nys Y (SRA Nouzilly FR). NSERC Collaborative Research Opportunities (CRO) grant, $445 000.
2005-2010 Starch granule membrane lipid transfer protein as piggyback carrier of molecular pharming production of recombinant proteins. PI: I Altosaar, Co-applicant: M. Tanchak, Univ Cape Breton, Sydney. NSERC Discovery grant, $28,000 p.a. over 5 years.
2002-2005 Rockefeller Foundation Food Security Program grant "Enhancing Yields in African Crops" - US$300 000.
2003-2004 ACCC PTP Fellowship grant “Comparative Bioethics in Estonia, pre- and post-EU Membership” $10,000.
2001-02 Rockefeller Foundation Food Security Program, Enhancing Yields in Crops" - US$70 000.
2000-2003 Rockefeller Foundation International Program in Rice Genetic Engineering RF 97001 #556 for Breeding, Safety Evaluation and Insect Resistance Management Sustainable Use of Bt Rice, US$80,000 p.a. with Qingyao Shu, Yingwu Xia (PI), Zhejiang Agricultural University, & Mingwei Gao, Institute of Nuclear Agricultural Science, ZAU, Hangzhou, China.
2002-2005 NSERC Research Grant #18022 "Molecular characterization of tryptophanin genes from cereals: a potential source of plant-derived antimicrobial peptides" $96 000. *with Tanchak, M.A., Cape Breton University, Sydney, Nova Scotia.
1991-2000 Rockefeller Foundation Rice Biotechnology Program grant "Genetic modification of starch and starch related enzymes in genetically engineered rice" - US$550 000.
1998-2000 Rockefeller Foundation Support Grant "Insect control technology in transgenic food crops: Postdoc Fellowship awardee Dr. N. Muthukrishnan" $34000.
1998-2001 Monsanto USA "Field trial evaluation in China of CryIA(b) and (c) gene stability in transgenic cereals, Oryza sativa." - US$144,000.
1998-2001 Innovation Foundation of Estonia -Collaborative Grant "Map-based cloning of dwarfing genes in rye" - $250,000. *with Truve, E., Tallinn Technical University.
1999-2002 National Biotechnology Strategy, HC LCDC (with Dr. A. Andonov (PI), R Peeling, L Robert) "Development of plant-based edible vaccines: Genetically altered plant foods to produce and deliver edible vaccines, Hepatitis & Chlamydia" - $140 000.
1996-99 Genentech, Inc. grant "Expression of recombinant human proteins in corn endosperm cells" -US$70 000.
1995-98 Hospital for Sick Children Foundation Grant #XG 95-002 "Development of subunit vaccines against cytomegalovirus: Production in transgenic plants" -$121 018 (with E Tackaberry).
1995-98 Bayer Inc./Red Cross contract #9511 "Evaluation of seed specific plant genetic expression systems for production of blood proteins" -$38 000 (with P Ganz).
1991-98 Ont. Min. Education. URIF contract "Biotechnology approaches (DNA probes- Anti-sense RNA therapeutics) for solving the pre-harvest sprouting problem in cereals" - $750 000.
1997-98 Health Canada, Virology Laboratories, LCDC collaborative contract "Transgenic grain as oral vaccine for Hepatitis A" - $14 000 (with A Andonov, M Callaghan).
;
Eesti teadlane Kanadas, kes töötas Eestis 1985-1991, ning alates aastast 1991 teeb koostööd erinevate Eesti teadlastega.;

Kvalifikatsioon

 
 
Teaduspreemiad ja tunnustused
2005, Illimar Altosaar, Taime pataloogia juhataja Jõgeva taime kasvatuse instituut, Tartu Ülikooli biokeemia õpetool 1993-1998
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; CERCS KLASSIFIKAATOR: P310 Proteiinid, ensümoloogia; TÄPSUSTUS: valkude produktsioon
 
 
Lisainfo
leijutaja ja firma juht Proteins Easy Corp.

Juhendatud järeldoktorid

  • 05.06.2018−... Jordan Jonquil Demone "Soil microbe gene expression of nitrous oxide reductase, nosZ, in Pseudomonas nautica" Ottawa Ülikool

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2.04.2020

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ProgramTypeNumberNameProject startProject endPrincipal investigatorInstitutionFinancing
1.1.5.3.4.1.3.2.V180232PKTT (MOBERA16)A liquid corneal glue-filler as an alternative to transplantation in high-risk patients 01.05.201931.12.2021Illimar AltosaarEstonian University of Life Sciences, Institute of Agricultural and Environmental Sciences, Chair of Crop Science and Plant Biology150 000,00 EUR