See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus
26.02.1974
+37126529651
karina.spunde@ut.ee
26.02.1974−04.06.2005 Ivanova, Karina

Teenistuskäik

Töökohad ja ametid
01.10.2018–30.11.2019   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, viroloogia teadur (1,00)
2008–2018   
Latvian Biomedical Research and Study Centre, Teadur (1,00)
2006–2007   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Vanemteadur (1,00)
2003–2006   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Teadur (1,00)
2001–2003   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Nooremteadur (1,00)
1998–2001   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Assistent (1,00)
1994–1998   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Latvia, Assistent (1,00)
 
 
Haridustee
1996–1998   
Läti Ülikool, biologia teaduskond
1992–1996   
Läti Ülikool, bioloogia teaduskond
 
 
Lisainfo
Participation in international research projects

Kvalifikatsioon

 
 
Teaduspreemiad ja tunnustused
2002, Karina Spunde, Matsumae International Foundation Fellowship
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.2. Mikrobioloogia; CERCS KLASSIFIKAATOR: B230 Mikrobioloogia, bakterioloogia, viroloogia, mükoloogia
 
 
Lisainfo
lecture course and certificate "Didactics of Higher Education: Contemporary Theories and Practice"
Additional training
Oral presentations at international meetings
Research experience and laboratory skills

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2017
5.2.
2017
5.1.
2016
5.1.
2014
1.1.
2012
5.1.
2012
5.1.
2011
1.3.
2006
1.3.
2004
1.3.
2002
1.2.
2000
29.06.2019
26.02.1974
+37126529651
karina.spunde@ut.ee
26.02.1974−04.06.2005 Ivanova, Karina

Career

Institutions and positions
01.10.2018–30.11.2019   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Research Fellow in Virology (1,00)
2008–2018   
Latvian Biomedical Research and Study Centre, Molecular virology group (1,00)
2006–2007   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Department of Oncovirology (1,00)
2003–2006   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Department of Oncovirology (1,00)
2001–2003   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Department of Oncovirology (1,00)
1998–2001   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Department of Oncovirology (1,00)
1994–1998   
August Kirchenstein Institute of Microbiology and Virology, Riga Stradins University, Latvia, laboratory of experimental models (1,00)
 
 
Education
1996–1998   
University of Latvia, Biology, MSc
1992–1996   
University of Latvia, Biology, BSc
 
 
Additional information
Participation in international research projects
2012-2013.
Bilateral Latvian-French OSMOSE project with University of Bordeaux entitled “ Capsid-genome interactions leading to genome release”.

1998-2000. Join research project of August Kirchenstein Institute of Microbiology and Virology, Department of Oncovirology, Riga, University of Latvia and Moscow Research Institute for Viral Preparations, Laboratory for Viral Infections Gene Therapy, Academy of Medical Sciences, Moscow, Russia, entitled “Design and testing of recombinant gene programming informational immunity against human T-cell leukemia virus”.

Qualifications

 
 
Honours & awards
2002, Karina Spunde, 1 October 2002- 31.March 2003 The Matsumae International Foundation Fellowship for research project “An investigation of anti-HTLV-1 activity of antisense RNAs targeted at HTLV-1 LTR U3 region and tax gene” at Kochi medical school, Kochi, Japan
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.2. Microbiology; CERCS CLASSIFICATION: B230 Microbiology, bacteriology, virology, mycology ; SPECIFICATION: Virology
 
 
Additional information
University of Latvia, Institute of Pedagogy and Psychology, lecture course "Didactics of Higher Education: Contemporary Theories and Practice" from 2002. August 1 through 2002 December 7, 2007 issued certificate no. 0028
Additional training


11-12 April 2013

“2013 Workshop on Confocal microscopy- Advanced techniques for modern biology” Nencki Institute of Experimental Biology, Poland


1-6 July 2002

European Summer School “Pharmacology of New anticancer Drugs” Bordeaux, France


30. June-6 July 1999

NorFA course “Biology of persistent and latent virus infections in animals and man” (the international course for Ph.D students) Jurmala, Latvia.


7-9 September 1995

Balt-Lasa workshop-demonstrations on use of laboratory animal in experiment (handling, anesthesia, blood collection tehniques), Riga, Latvia

Oral presentations at international meetings


2016

European Biotechnology Congress 2016; May 5-7, Riga, Latvia


2015

Global Virus Network, Scandinavia-Baltic-Ukraine region meeting, 2015; June 8-10 Djurönäset,, Sweden



2014

Global Virus Network, Scandinavia-Balti-Ukraine region meeting, 2014; June 11-13, Laulasmaa, Estonia


2000

European association for cancer research XVI Meeting, 2000; 30 May – 3 June, Halkidiki, Kassandra, Greece


1998

International Meeting Blood Borne Virus Infections, 1998; May26-27 Riga, Latvia


1995

Balt-LASA V international conference From Breeding to Experiment, 1995; September 7-9 Riga, Latvia
Research experience


2008-2018

Study of HBV core (HBc) protein in eukariotic cells: alphavirus driven expression of different HBc variants in BHK-21 cells, study of its stability, degradation pathway, HBc modifications, particle formation.


2005-2006

Study of Parvovirus B19 and Human herpesvirus 6 incidence in patients with juvenile arthritis, real-time PCR detection of viral load.


1997-2005

Retroviruses of the HTLV-BLV group, HTLV-I infected cell cultures, transfection of mammalian cell cultures. Studies of HTLV-1 integration and expression by immunological and molecular biological methods, specific inhibition of virus replication by antisense RNA. Gene therapy of viral infections.


1995-1996

Different breeding methods of nude mice. Thymus grafting to nude mice. Transplantation of human tumors onto nude mice, research of tumor growth parameters.


Skills

Standard molecular biology techniques for nucleic acid and protein analysis, viral particle purification, MALDI-TOF mass spectrometry analysis of proteins. Cell culturing,cell line engineering and cloning, classic gene engineering techniques, 3D cell culture (soft agar), subcutaneous human biopsy xenograft obtainment in nude mice (melanoma).

Publications

Category
Year
Publication
 
1.1.
2017
5.2.
2017
5.1.
2016
5.1.
2014
1.1.
2012
5.1.
2012
5.1.
2011
1.3.
2006
1.3.
2004
1.3.
2002
1.2.
2000
29.06.2019

Otsi publikatsiooni

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PublikatsioonAutoridAastaVäljaande pealkiriKlassifikaatorFailAsutused
Application of Alphaviral Vectors for Immunomodulation in Cancer Therapy.Zajakina, Anna; Spunde, Karina; Lundstrom, Kenneth2017Current Pharmaceutical Design1.1.
Design and Synthesis of Small-molecule Hepatitis B Virus Capsid Self-assembly Inhibitors. Sīpola A., Dubova U. N.,Vīgante B., Spunde K., Kozlovska T. and Duburs G.20175.2.Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut
Investigation of interaction of preS1-addressed virus like particles with hepatitis B virus receptor NTCP expressed in mammalian cellsSpunde, Karina; Renhofa, Regina; Fjodorovs, Alexeys; Vezane, Alexandra; Kozlovska, Tatyana2016Journal of Biotechnology5.1.
Hepatitis B virus nucleocapsid particles produced in eukaryotic cells: Properties and purificationSpunde, Karina; Eihentale, Alma; Zajakina, Anna; Kozlovska, Tatyana; Pumpens, Paul2014Journal of Biotechnology5.1.
Semliki Forest virus biodistribution in tumor-free and 4T1 mammary tumor-bearing mice: a comparison of transgene delivery by recombinant virus particles and naked RNA replicon.Vasilevska, J; Skrastina, D; Spunde, K; Garoff, H; Kozlovska, T; Zajakina, A2012Cancer Gene Therapy1.1.
Producing of HCV-like particles in alphaviral expression systemsAleksejeva, E.; Sominskaya, I.; Jansons, J.; Spunde, K.; Kozlovska, T.2012Journal of Viral Hepatitis5.1.
Efficient production of hepatitis B core particles in stably transfected BHK-21 cellsSpunde, Karina; Zajakina, Anna; Alekseeva, Ekaterina; Kozlovska, Tatyana2011Current Opinion in Biotechnology5.1.
HHV-6 un parvovīrusa B19 infekciju sastopamība pacientiem ar juvenilo artrītuRumba I, Kozireva S, Ivanova K, Gandzs A. Saulīte I, Bracslavska O.2006Scientific Papers University of Latvia, Medicine1.3.Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut
Construction of the plasmids carrying HTLV-1 sequences suitable for study of their effect on viral replication. Ivanova K., Takemoto S., Taguchi H., Miklaševičs E., Murovska M. 2004Scientific Papers University of Latvia, Medicine1.3.Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut
Antisense approach of inhibiting replication of human T-cell lymphotropic virus type 1 (HTLV-1)Ivanova K, Murovska M.2002Proceedings of the Latvian Academy of Sciences1.3.Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut
Bratslavska O., Ivanova K., Kozireva S., Kalnberza G., Tomsone V., Murovska M. Malignant transformation of human non-lymphoid cell line, infected by HTLV-I. Experimental Oncology, 2000; 22:110-117Bratslavska Olga, Ivanova Karina, Kozireva Svetlana, Kalnberza Gunta, Tomsone Vera, Murovska Modra2000Experimental Oncology1.2.Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut