See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Kristi Huik

https://www.etis.ee/CV/Kristi_Huik/est
30.08.1983
kristi.huik@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2021–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, meditsiinilise mikrobioloogia ja viroloogia kaasprofessor (1,00)
2020–...   
USA Tervise Instituudid (NIH), Special volunteer (0,10)
01.09.2020–31.12.2020   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, meditsiinilise mikrobioloogia ja viroloogia dotsent (1,00)
26.02.2018–31.08.2020   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, meditsiinilise viroloogia ja mikrobioloogia teadur (0,25)
14.02.2018–26.08.2020   
USA Tervise Instituudid (NIH), Järeldoktor (1,00)
01.01.2016–25.02.2018   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, meditsiinilise viroloogia ja mikrobioloogia teadur (1,00)
01.09.2015–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Mikrobioloogia instituut, meditsiinilise viroloogia ja mikrobioloogia teadur (1,00)
01.06.2014–31.08.2015   
Tartu Ülikool, Arstiteaduskond, Mikrobioloogia instituut, meditsiinilise viroloogia teadur (1,00)
01.03.2014–31.05.2014   
Tartu Ülikool, Arstiteaduskond, Mikrobioloogia instituut, meditsiinilise mikrobioloogia nooremteadur (1,00)
01.09.2013–28.02.2014   
Tartu Ülikool, Arstiteaduskond, Mikrobioloogia instituut, laborant (1,00)
01.05.2006–31.08.2013   
Tartu Ülikool, Arstiteaduskond, Mikrobioloogia instituut, laborant (0,50)
 
 
Haridustee
2002–2007   
Tartu Ülikool, Arstiteaduskond, Proviisoriõpe
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2010−...   
European Society for translational Antiviral Research (ESAR) nõukogu liige

Kvalifikatsioon

Teaduskraadid
Kristi Huik, doktorikraad, 2014, (juh) Tõnis Karki; Irja Lutsar, The Influence of Host Genetic Factors on the Susceptibility to HIV and HCV Infections Among Intravenous Drug Users (Inimese geneetiliste faktorite mõju HIV-i ja C-hepatiidi viirusesse nakatumisele süstivate narkomaanide hulgas), Tartu Ülikool, Arstiteaduskond.
Kristi Huik, magistrikraad, 2007, (juh) Tõnis Karki, HIV-1 subtüübiline jaotuvus Eestis, Tartu Ülikool, Arstiteaduskond, Farmaatsia instituut.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; TÄPSUSTUS: HI-viiruse tropismi, peremeesorganismi geneetiliste fakotite ja ko-infektsioonide mõju haiguse kulule

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

1.1. Teadusartiklid, mis on kajastatud Web of Science andmebaasides Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index ja/või andmebaasis Scopus (v.a. kogumikud)
 
Kõivumägi, K.; Geller, J.; Toompere, K.; Soeorg, H.; Kallas, E.; Jõegeda, E.-L.; Huik, K.; Lutsar, I. (2022). Norovirus strains among children aged 0-18 years hospitalized with acute gastroenteritis in Estonia 2015-2016. Journal of Medical Virology, 94 (6), 2632−2639. DOI: 10.1002/jmv.27495.
 
Kase, Kerstin; Avi, Radko; Toompere, Karolin; Rajasaar, Heli; Pauskar, Merit; Soodla, Pilleriin; Jogeda, Ene-Ly; Zilmer, Kai; Lutsar, Irja; Huik, Kristi (2021). Dynamics of hepatitis C epidemic among people living with HIV in Estonia based on Estonian HIV cohort study. BMC Infectious Diseases, 21 (1), ARTN 792. DOI: 10.1186/s12879-021-06521-w.
 
Koivumagi, Kadri; Soeorg, Hiie; Toompere, Karolin; Kallas, Eveli; Joegeda, Ene-Ly; Lass, Evely; Huik, Kristi; Lutsar, Irja (2021). Rotavirus Strain Surveillance in Estonia After Introduction of Rotavirus Universal Mass Vaccination. The Pediatric Infectious Disease Journal, 40 (5), 489−494. DOI: 10.1097/INF.0000000000003039.
 
Kõivumägi, Kadri; Toompere, Karolin; Soeorg, Hiie; Kallas, Eveli; Jõgeda, Ene-Ly; Huik, Kristi; Lutsar, Irja (2020). Acute gastroenteritis hospitalizations after implementation of universal mass vaccination against rotavirus. Vaccine, 38 (13), 2879−2886. DOI: 10.1016/j.vaccine.2020.01.098.
 
Sepp, Epp; Andreson, Reidar; Balode, Arta; Bilozor, Anastasia; Brauer, Age; Egorova, Svetlana; Huik, Kristi; Ivanova, Marina; Kaftyreva, Lidia; Kõljalg, Siiri; Koressaar, Triinu; Makarova, Maria; Miciuleviciene, Jolanta; Pai, Kristiine; Remm, Maido; Rööp, Tiiu; Naaber, Paul (2019). Phenotypic and Molecular Epidemiology of ESBL-, AmpC-, and Carbapenemase-Producing Escherichia coli in Northern and Eastern Europe. Frontiers in Microbiology, 10, ARTN 2465. DOI: 10.3389/fmicb.2019.02465.
 
Soodla, Pilleriin; Huik, Kristi; Pauskar, Merit; Cuypers, Lize; Van Laethem, Kristel; Rajasaar, Heli; Kallas, Eveli; Lepa, Helen; Velts-Lindh, Anna; Jogeda, Ene-Ly; Lutsar, Irja; Avi, Radko (2019). Stable level of HIV transmitted drug resistance in Estonia despite significant scale-up of antiretroviral therapy. Infection Genetics and Evolution, 75, ARTN 103901. DOI: 10.1016/j.meegid.2019.05.019.
 
Huik, Kristi; Soodla, Pilleriin; Pauskar, Merit; Owen, S. Michele; Luo, Wei; Murphy, Gary; Jogeda, Ene-Ly; Kallas, Eveli; Rajasaar, Heli; Avi, Radko; Masciotra, Silvina; Lutsar, Irja; Del Amo, Julia; Meyer, Laurence; Bucher, Heiner C.; Chene, Genevieve; Hamouda, Osamah; Pillay, Deenan; Prins, Maria; Rosinska, Magda ... Scott, Martin (2019). The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx. PLoS ONE, 14 (5), ARTN e0217048. DOI: 10.1371/journal.pone.0217048.
 
Soodla, P.; Simmons, R.; Huik, K.; Pauskar, M.; Jõgeda, E.L.; Rajasaar, H.; Kallaste, E.; Maimets, M.; Avi, R.; Murphy, G.; Porter, K.; Lutsar, I.; Del Amo, J.; Meyer, L.; Bucher, H.C.; Chêne, G.; Hamouda, O.; Pillay, D.; Prins, M.; Rosinska, M. ... Rockstroh, J. (2018). HIV incidence in the Estonian population in 2013 determined using the HIV-1 limiting antigen avidity assay. HIV Medicine, 19 (1), 33−41. DOI: 10.1111/hiv.12535.
 
Jõgeda, E-L; Avi, R; Pauskar, M; Kallas, E; Karki, T; Des Jarlais, D; Uusküla, A; Toompere, K; Lutsar, I; Huik, K (2018). Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs. Journal of Medical Virology, 90 (11), 1779−1783. DOI: 10.1002/jmv.25258.
 
Jogeda, Ene-Ly; Huik, Kristi; Pauskar, Merit; Kallas, Eveli; Karki, Tonis; Jarlais, Don Des; Uuskula, Anneli; Lutsar, Irja; Avi, Radko (2017). Prevalence and Genotypes of GBV-C and Its Associations With HIV Infection Among Persons Who Inject Drugs in Eastern Europe. Journal of Medical Virology, 89 (4), 632−638. DOI: 10.1002/jmv.24683.
 
Soeorg, Hiie; Metsvaht, Tuuli; Eelmäe, Imbi; Merila, Mirjam; Treumuth, Sirli; Huik, Kristi; Jürna-Ellam, Marika; Ilmoja, Mari-Liis; Lutsar, Irja (2017). The role of breast milk in the colonization of neonatal gut and skin with coagulase-negative staphylococci. Pediatric Research, 82 (5), 759−767. DOI: 10.1038/pr.2017.150.
 
Soeorg, H.; Huik, K.; Parm, Ü.; Ilmoja, ML.; Metsvaht, T.; Lutsar, I. (2017). Molecular epidemiology of Staphylococcus epidermidis in neonatal intensive care units. APMIS, 125, 63−73. DOI: 10.1111/apm.12637.
 
Huik, Kristi; Avi, Radko; Pauskar, Merit; Kallas, Eveli; Jõgeda, Ene-Ly; Karki, Tõnis; Rüütel, Kristi; Talu, Ave; Abel-Ollo, Katri; Uusküla, Anneli; Carrillo, Andrew; Ahuja, Sunil K; He, Weijing; Lutsar, Irja (2016). A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. PLoS ONE, 11 (6), e0156850−e0156850. DOI: 10.1371/journal.pone.0156850.
 
Avi, Radko; Pauskar, Merit; Karki, Tõnis; Kallas, Eveli; Jõgeda, Ene-Ly; Margus, Tõnu; Huik, Kristi; Lutsar, Irja (2016). Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia. Journal of Medical Virology, 88 (3), 448−454. DOI: 10.1002/jmv.24361.
 
Kallas, Eveli; Huik, Kristi; Türk, Silver; Pauskar, Merit; Jõgeda, Ene-Ly; Šunina, Marina; Karki, Tõnis; Des Jarlais, Don; Uusküla, Anneli; Avi, Radko; Lutsar, Irja (2016). T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use. Viral Immunology, 0−0. DOI: 10.1089/vim.2016.0057.
 
Kallas, Eveli; Huik, Kristi; Türk, Silver; Pauskar, Merit; Jõgeda, Ene-Ly; Šunina, Marina; Karki, Tõnis; Des Jarlais, Don; Uusküla, Anneli; Avi, Radko; Lutsar, Irja (2016). Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs. Medical Microbiology and Immunology, 205 (3), 231−239. DOI: 10.1007/s00430-015-0444-8.
 
Jõgeda, Ene-Ly; Avi, Radko; Pauskar, Merit; Kallas, Eveli; Karki, Tõnis; Des Jarlais, Don; Uusküla, Anneli; Lutsar, Irja; Huik, Kristi (2016). Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe. Infection Genetics and Evolution, 43, 83−85. DOI: 10.1016/j.meegid.2016.05.022.
 
Koljalg, Siiri; Telling, Kaidi; Huik, Kristi; Murruste, Marko; Saarevet, Virve; Pauskar, Merit; Lutsar, Irja (2015). First report of Wohlfahrtiimonas chitiniclastica from soft tissue and bone infection at an unusually high northern latitude. Folia Microbiologica, 60 (2), 155−158. DOI: 10.1007/s12223-014-0355-x.
 
Kallas, E.; Huik, K.; Pauskar, M.; Jõgeda, E.-L.; Karki, T.; Des Jarlais, D.; Uusküla, A.; Avi, R.; Lutsar, I. (2015). Influence of interleukin 10 polymorphisms -592 and -1082 to the HIV, HBV and HCV serostatus among intravenous drug users. Infection Genetics and Evolution, 30, 175−180. DOI: 10.1016/j.meegid.2014.12.023.
 
Soodla, P.; Rajasaar, H.; Avi, R.; Zilmer, K.; Kink, K.; Novikova, L.; Huik, K.; Maimets, M.; Lutsar, I. (2015). Design and structure of the Estonian HIV Cohort Study (E-HIV). Infectious Diseases, 47 (11), 768−675. DOI: 10.3109/23744235.2015.1061203.
 
Lillo, Jana; Pai, Kristiine; Bolde, Arta; Makarova, Mariia; Huik, Kristi; Kõljalg, Siiri; Ivanova, Marina; Kaftyreva, Lidia; Miciuleviciene, Jolanata; Naaber, Paul; Parv, Kristel; Pavelkovich, Anastasia; Rööp, Tiiu; Toompere, Karolin; Suzhaeva, Ludmila; Sepp, Epp (2014). Differences in extended-spectrum beta-lactamase producing Escherichia coli virulence factor genes in the Baltic Sea region. BioMed Research International, 427254, 1−7. DOI: 10.1155/2014/427254.
 
Huik, K.; Avi, R.; Uibopuu, H.; Pauskar, M.; Margus, T.; Karki, T.; Krispin, T.; Kool, P.; Rüütel, K.; Talu, A.; Abel-Ollo, K.; Uusküla, A.; Carrillo, AQ.; He, W.; Ahuja, SK.; Lutsar, I. (2014). Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 66 (3), 239−244. DOI: 10.1097/QAI.0000000000000127.
 
Avi, R; Huik, K; Pauskar, M; Ustina, V; Karki, T; Kallas, E; Jõgeda, EL; Krispin, T; Lutsar, I (2014). Transmitted drug resistance is still low in newly diagnosed human immunodeficiency virus type 1 CRF06_cpx-infected patients in Estonia in 2010. Aids Research and Human Retroviruses, 30 (3), 278−283. DOI: 10.1089/aid.2012.0357.
 
Huik, K; Avi, R; Pauskar, M; Kallas, E; Jõgeda, EL; Karki, T; Marsh, K; Des Jarlais, D; Uusküla, A; Lutsar, I (2013). Association between TLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users. Infection Genetics and Evolution, 20, 78−82. DOI: 10.1016/j.meegid.2013.08.008.
 
Huik, K; Avi, R; Carrillo, A; Harper, N; Pauskar, M; Sadam, M; Karki, T; Krispin, T; He, W; Lutsar, I (2013). CCR5 Haplotypes Influence HCV Serostatus in Caucasian Intravenous Drug Users. PLoS ONE, 8 (7), e70561. DOI: 10.1371/journal.pone.0070561.
 
Soeorg, H.; Huik, K.; Parm, U.; Ilmoja, ML.; Metelskaja, N.; Metsvaht, T.; Lutsar, I. (2013). Genetic Relatedness of Coagulase-Negative Staphylococci from Gastrointestinal Tract and Blood of Preterm Neonates with Late-Onset Sepsis. The Pediatric Infectious Disease Journal, 32 (4), 389−393. DOI: 10.1097/INF.0b013e3182791abd.
 
Soeorg, H.; Tamm, E.; Huik, K.; Pauskar, M.; Mägi, D.; Pruudel, K.; Vainomäe, L.; Moosar, L.; Kirss, K.; Torm, S.; Närska, M.; Pütsepp, A.; Nurm, H.; Pruunsild, K.; Jänes, A.; Zilmer, K.; Lutsar, I. (2012). Group A rotavirus genotypes circulating prior to implementation of a National Immunization Program in Estonia. Human Vaccines, 8 (4), 465−469. DOI: 10.4161/hv.19135.
 
Avi, R; Huik, K; Pauskar, M; Ustina, V; Karki, T; Krispin, T; Ainsalu, K; Paap, P; Schmidt, J; Nikitina, N; Lutsar, I. (2011). Emerging Transmitted Drug Resistance in Treatment Naive Human Immunodeficiency Virus - 1 CRF06_cpx Infected Patients in Estonia. Scandinavian Journal of Infectious Diseases, 43 (2), 122−128.
 
Avi, R.; Huik, K.; Sadam, M.; Karki, T.; Krispin, T.; Ainsalu, K.; Paap, P.; Schmidt, J.; Nikitina, N.; Lutsar, I. (2010). Characterization of Integrase Region Polymorphisms in HIV-1 CRF06_cpx Viruses in Treatment Naïve Patients in Estonia. Aids Research and Human Retroviruses, 26 (10), 1109−1113. DOI: 10.1089/aid.2010.0097.
 
Huik, K.; Sadam, M.; Karki, T.; Avi, R.; Krispin, T.; Paap, P.; Rüütel, K.; Uusküla, A.; Talu, A.; Abel-Ollo, K.; Lutsar, I. (2010). CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users. The Journal of Infectious Diseases, 730−739. DOI: 10.1086/650491.
 
Avi, R; Huik, K; Sadam, M; Karki, T; Krispin, T; Ainsalu, K; Paap, P; Schmidt, J; Nikitina, N; Lutsar, I. (2009). Absence of Genotypic Drug Resistance and Presence of Several Naturally Occurring Polymorphisms of Human Immunodeficiency Virus-1 CRF06_cpx in Treatment-Naive Patients in Estonia. Journal of Medical Virology, 81 (6), 953−958. DOI: 10.1002/jmv.21482.
1.3. Eelretsenseeritud teadusartiklid Eesti ja teiste riikide eelretsenseeritavates teadusajakirjades, millel on kohalik toimetuskolleegium, või eelretsenseeritud teadusartiklid Eesti kultuurile olulistes ajakirjades või teadusartiklid ajakirjades Akadeemia, Looming ja Vikerkaar.
 
Irja Lutsar, Radko Avi, Pilleriin Soodla, Kristi Huik, Karolin Toompere, Margus Jääger, Kersti Kink, Kaisa Kirs, Heli Rajasaar, Svetlana Semjonova, Kai Zilmer (2018). UNAIDSi kriteeriumid HIV-infektsiooni monitoorimiseks: olukord Eestis 2017. aastal E-HIVi põhjal. Eesti Arst, 97 (10), 527−534.
2.4. Kõrgkooliõpikud
 
Merits, Andres; Abroi, Aare; Kurg, Reet; Žusinaite, Eva; Truve, Erkki; Sarmiento, Cecilia; Sõmera, Merike; Saar, Tiiu; Viltrop, Arvo; Lutsar, Irja; Avi, Radko; Karki, Tõnis; Huik, Kristi; Kõljalg, Siiri; Brilene, Tatjana; Roots, Irja;Inno, Heleri (2022). Üldine ja Meditsiiniline viroloogia. Tartu: Tartu Ülikooli kirjastus [ilmumas].
3.5. Artiklid/ettekanded, mis on avaldatud kohalikes konverentsikogumikes
 
Tamman, S; Denks, K; Huik, K; Parm, Ü; Avi, R; Lutsar, I. (2008). Klebsiella pneumoniae genotüpiseerimine multiensüüm-multipleks amplified fragmrnt length polymorphism PCR (AFLP-PCR) meetodil. Eesti Arst.
5.1. Konverentsiteesid, mida kajastab Thomson Reuters Web of Science
 
Denks, K.; Huik, K.; Avi, R.; Sadam, M.; Krispin, T.; Lutsar, I. (2007). GB virus C infection among HIV-positive patients in Estonia. International Journal of Antimicrobial Agents, 29 (3), S155−S155.
 
Avi, R.; Huik, K.; Karki, T.; Sadam, M.; Paap, P.; Smidt, J.; Ainsalu, K.; Krispin, T.; Lutsar, I (2007). The coexistence of secondary PR mutations M36I, K20I and L63H predominates in CRF06_cpx and its next generation recombinant virusese circulating in Estonian treatment naive patients. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 29. , S549−S549.
5.2. Konverentsiteesid, mis ei kuulu valdkonda 5.1
 
Huik, Kristi; Virga, James; Ganesan, Anuradha; McMahon, Deborah; Utay, Netanya; Rehm, Catherine; Bell, Jennifer; Maldarelli, Frank (2020). Changes in Gut Microbiome in HIV-Infected Individuals Undergoing Long Term Antiretroviral Therapy Receiving Rifaximin: Results of the GUTCHEK Study. In: . International Workshop on Microbiome in HIV Pathogenesis, Prevention and Treatment 2020. International Workshop on Microbiome in HIV Pathogenesis, Prevention and Treatment 2020.
 
Kallas, E.; Avi, R.; Huik, K.; Türk, S.; Pauskar, M.; Jõgeda, E.-.L.; Šunina, M.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2015). The distribution of TEMRA cells is influenced by HIV, HBV, HCV infections and intravenous drug use. 25th European Congress of Clinical Microbiology and Infectious Diseases; Copenhagen, Denmark, 25.-28. April 2015.
 
Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. (2015). Molecular epidemiology of Staphylococcus epidermidis colonizing gastrointestinal tract of neonates hospitalized to intensive care unit. The 25th European Congress of Clinical Microbiology and Infectious Diseases, April 25-28, 2015, Copenhagen, Denmark..
 
Naaber, Paul; Balode, Arta; Egorova, Svetlana; Huik, Kristi; Ivanova, Marina; Kaftyreva, Lidia; Kõljalg, Siiri; Kõressaar, Triinu; Lillo, Jana; Löhr, Iren; Miciuleviciene, Jolanta; Pai, Kristiine; Pavelkovich, Anastassia; Remm, Maido; Sepp, Epp (2015). The epidemiology of CTX-M group genes among clinical Escherichia coli strains in Estonia, Latvia, Lithuania, Norway and Russia.
 
Jõgeda, Ene-Ly; Avi, Radko; Pauskar, Merit; Kallas, Eveli; Karki, Tõnis; Jarlais, Don Des; Uusküla, Anneli; Lutsar, Irja; Huik, Kristi; (2015). HTLV-1/2 is rare among Eastern-European intravenous drug users (IDUs). Retrovirology, 12, P79−P79. DOI: doi.org/10.1186/1742-4690-12-S1-P79.
 
Soeorg, H.; Huik, K.; Parm, Ü.; Ilmoja, ML.; Metsvaht, T.; Lutsar, I. (2014). Virulentsus- ja resistentsusgeenide varieeruvus lasteintensiivravi osakondades levivate Staphylococcus epidermidis’te hulgas. Eesti Arst, 24−24. (93; Lisa 1).
 
Pai, K.; Huik, K.; Ivanova, M.; Kõljalg, S.; Pavelkovich, K.; Parv, K.; Rööp, T.; Sepp, E.; Naaber, P. (2014). Detection and molecular characterisation of extended-spectrum beta-lactamase-producing Escherichia coli sequence type ST131 from the Baltic region. European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain, 10-13 May 2014.
 
Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. (2014). Genetic variation of virulence and resistance genes in Staphylococcus epidermidis circulating in neonatal intensive care units. The 24th European Congress of Clinical Microbiology and Infectious Diseases, May 10-13, 2014, Barcelona, Spain..
 
Avi, R.; Huik, K.; Pauskar, M.; Kallas, E.; Jõgeda, E.-L.; Zilmer, K.; Ustina, V.; Novikova, L.; Karki, T.; Kisand, V.; Lutsar, I. (2014). Full-Length Genome Sequences of Estonian HIV-1 CRF06 and Eastern-European Subtype A1 Recombinant Forms. 7th National Congress HIV/AIDS and the 2nd Central European HIV Forum, Sibiu, Romania, 29-31 May 2014.
 
Pauskar, M.; Huik, K.; Avi, R.; Kallas, E.; Jõgeda, E.-L.; Karki, T.; Semjonova, S.; Smidt, J.; Novikova, L.; Ainsalu, K.; Lutsar, I. (2014). Antiretroviral drug resistance and viral tropism in HIV-1 CRF06_cpx infected patients failing antiretroviral (ARV) therapy. 7th National Congress HIV/AIDS and the 2nd Central European HIV Forum, Sibiu, Romania, 29-31 May 2014.
 
Kallas, E.; Huik, K.; Avi, R; Pauskar, M.; Jõgeda, E.-L.; Karki, T.; Marsh, K.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2014). NLRP3 genotype CG increases the risk of HIV-1 in Caucasian intravenous drug users (IDUs). European Human Genetics Conference 2014, Milan, Italy, 31 May-3 June 2014.
 
Jõgeda, E.-L.; Huik, K.; Avi, R; Pauskar, M., Kallas, E.; Karki, T.; Marsh, K.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2014). Associations between MX2 polymorphism and the acquisition of HIV and co-infections in Caucasian intravenous drug users (IDUs). European Human Genetics Conference 2014, Milan, Italy, 31 May-3 June 2014.
 
Kallas, E.; Avi, R.; Huik, K.; Türk, S.; Pauskar, M.; Jõgeda, E.-.L.; Šunina, M.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2014). Injection drug use influences T-cell distribution and CCR5 expression in HIV+ and ESN population. 24th European Congress of Clinical Microbiology and Infectious Diseases; Barcelona; 10-13 May 2014.
 
Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. (2014). Vancomycin-heteroresistance in Staphylococcus epidermidis colonizing neonates in neonatal intensive care units. The 32nd Annual Meeting of the European Society for Paediatric Infectious Diseases, May 6-10, 2014, Dublin, Ireland..
 
Avi, Radko; Huik, Kristi; Pauskar, Merit; Kallas, Eveli; Jõgeda, Ene-Ly; Karki, Tõnis; Šmidt, Jelena; Novikova, Lilia; Semjonova, Svetlana; Lutsar, Irja. (2013). Substitutions in RNaseH and Connection domain of HIV-1 CRF06_cpx viruses in treatment naive and treatment experienced populations. 11th European Meeting on HIV & Hepatitis- Treatment Strategies & Antiviral Drug Resistance; Rome; 20-22 March 2013. , 35−35.
 
Jõgeda, Ene-Ly; Huik, Kristi; Pauskar, Merit; Kallas, Eveli; Krispin, Tõnu; Karki, Tõnis; Marsh, Kristina; Des Jarlais, Don; Uusküla, Anneli; Avi, Radko; Lutsar, Irja. (2013). The prevalence of GBV-C and its associations with HIV infection among Estonian intravenous drug users. Reviews in Antiviral Therapy Infectious Diseases: 11th European Meeting on HIV & Hepatitis- Treatment Strategies & Antiviral Drug Resistance; Rome; 20-22 March 2013. , 46−47.
 
Kallas, Eveli; Huik, Kristi; Av1, Radko; Pauskar, Merit; Jõgeda, Ene-Ly; Karki, Tõnis; Marsh, Kristina; Des Jarlais, Don; Uusküla, Anneli; Lutsar, Irja (2013). The IL-10 promoter genotype AA at -592 is correlated with increased susceptibility to hepatitis B but not HIV infection in Caucasian intravenous drug users. European Human Genetics Conference 2013, Paris, France, 8.06.13-11.06.13.
 
Lillo, J; Balode, A; Egorova, S; Huik, K; Ivanova, M; Kaftyreva, L; Makarova, M; Miciuleviciene, J; Naaber, P; Pai, K; Parv, K; Pavelkovich, A; Rööp, T; Sepp, E. (2013). Differences in virulence factors of Escherichia coli isolated from the Baltic Sea region. 23 nd European Congress ofClinical Microbiology and Infectious Diseases; Berlin; 27-30 April 2013.
 
Naaber, P; Balode, A; Djundika, T; Egorova, S; Huik, K; Kaftyreva, L; Kamõnina, N; Kirs, K; Kõljalg, S; Konovalenko, I; Kurchikova, T; Lillo, J; Lipskaya, L; Lõivukene, L; Makarova, M; Makstutis, G; Miciuleviciene, J; Morozova, O; Pai, K; Parv, K ... Ivanova, M (2013). Epidemiology of extended-spectrum beta-lactamases-producing Escherichia coli and Klebsiella pneumoniae in the Baltic Sea region. 23 nd European Congress ofClinical Microbiology and Infectious Diseases; Berlin; 27-30 April 2013.
 
Pai, K; Balode, B; Egorova, S; Huik, K; Ivanova, M; Kaftyreva, L; Kõljalg, S; Lillo, J; Miciuleviciene, J; Naaber, P; Parv, K; Pavelkovich, A; Rööp, T; Sepp, E. (2013). The molecular epidemiology of extended-spectrum beta-lactamases-producing Escherichia coli and Klebsiella pneumoniae in the Baltic Sea region. 23 nd European Congress ofClinical Microbiology and Infectious Diseases; Berlin; 27-30 April 2013.
 
Avi, R.; Huik, K.; Pauskar, M., Lutsar, I.; Vandamme, A.; Abecasis, A. (2012). The population dynamics of the HIV-1 epidemic in Estonia through virus genetic analysis and national case recording. 17th International BioInformatics Workshop on Virus Evolution and Molecular Epidemiology, 27-31 August 2012 Belgrade Serbia.
 
Uibopuu, H.; Huik, K.; Avi, R.; Pauskar, M.; Kallas, E.; Karki, T.; Krispin, T.; Kool, P.; Schmidt, J.; Rüütel, K.; Talu, A.; Abel-Ollo, K.; Uusküla, A.; Lutsar, I. (2012). Viral tropism of HIV-1 CRF06_cpx and its association with CCR5 haplotypes. 10th European Meeting on HIV & Hepatitis - Treatment Strategies & Antiviral Drug Resistance, 28 - 30 March 2012 Barcelona Spain.
 
Pauskar, M.; Avi, R.; Huik, K.; Ustina, V.; Jõgeda, E.; Kallas, E.; Karki, T.; Krispin, T.; Lutsar, I. (2012). Transmitted drug resistance is 4.5% in newly diagnosed mainly HIV-1 CRF06_cpx infected patients in Estonia in 2010. 10th European Meeting on HIV & Hepatitis - Treatment Strategies & Antiviral Drug Resistance, 28 - 30 March 2012 Barcelona Spain.
 
Avi, R.; Huik, K.; Pauskar, M.; Kallas, E.; Karki, T.; Krispin, T.; Ainsalu, K.; Semjonova, S.; Kool, P.; Novikova, L.; Schmidt, J.; Lutsar, I. (2012). The pattern of drug resistance mutations in HIV-1 CRF06_cpx viruses failing the first-line NNRTI+2NRTI antiretroviral therapy. 10th European Meeting on HIV & Hepatitis - Treatment Strategies & Antiviral Drug Resistance, 28 - 30 March 2012 Barcelona Spain.
 
Kallas, E.; Avi, R.; Huik, K.; Pauskar, M.; Ustina, V.; Karki, T.; Krispin, T.; Ainsalu, K.; Semjonova, S.; Kool, P.; Novikova, L.; Schmidt, J.; Lutsar, I. (2012). HIV Type-1 CRF06_cpx P(T/S)AP Late Domain duplications are outselected among treatment experienced compared to treatment naïve patients. Reviews in Antiviral Therapy & Infectious Diseases. .
 
Soeorg, Hiie; Huik, Kristi; Štšepetova, Jelena; Truusalu, Kai; Pauskar, Merit; Parm, Ülle; Ilmoja, Mari-Liis; Metsvaht, Tuuli; Lutsar, Irja (2012). Genetic relatedness of coagulase-negative staphylococci (CoNS) from gastrointestinal tract (GIT) and blood of neonates with late-onset sepsis (LOS). The 30th Annual Meeting of the European Society for Paediatric Infectious Diseases, May 8-12, 2012, Thessaloniki, Greece..
 
Soeorg H, Huik K, Pauskar M, Tamm E, et al. (2011). Molecular epidemiology of Rotaviruses in Estonia in 2007-2008. The 29th Annual Meeting of the European Society for Paediatric Infectious Diseases, June 7-11, 2011, The Hague, the Nertherlands..
 
Huik, Kristi; Parm, Ülle; Denks, Kärt; Pauskar, Merit; Lutsar, Irja. (2010). magA, k2A, rmpA and kfu genes are not related to onset neonatal sepsis of Klebsiella pneumoniae in neonatal intensive care units in two major hospitals in Estonia. European Congress of Clinical Microbiology and Infectious Diseases, Vienna 2010..
 
Huik, K.; Avi, R.; Sadam, M.; Karki, T.; Denks, K.; Krispin, T.; Ustina, V.; Rüütel, K.; Uusküla, A.; Murphy, G.; Lutsar, I. (2009). Performance of the BED-CEIA in population infected with HIV1 recombinant viruses CRF06cpx and CRF06A. Clinical Microbiology and Infection: 19th European Congress of Clinical Microbiology and Infectious Diseases Helsinki, Finland, 16 - 19 May 2009.
 
Huik, K.; Avi, R.; Sadam, M.; Karki, T.; Albert, J.; Lutsar, I. (2008). Drug Resistance Mutations in HIV-1 CRF06_cpx Viruses Isolated from Treatment Naïve and Experienced Patients. European Journal of Medical Research: 19th European Students’ Conference; Berlin; 28 September - 3 October 2008.
 
Avi, R.; Huik, K.; Karki, T.; Sadam, M.; Krispin, T.; Ainsalu, K.; Paap, P.; Schmidt, J.; Nikitina, N.; Lutsar, I. (2008). Drug Resistance Mutations and Genetic Barrier for Drug Resistance Development in Estonian HIV-1 CRF06_cpx Integrase Sequences. 14th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology; Cape Town, South Africa; 1-5 September 2008.
 
Avi, R.; Huik, K.; Sadam, M.; Karki, T.; Krispin, T.; Paap, P.; Ainsalu, K.; Schmidt, J.; Nikitina, N.; Lutsar, I. (2008). Natural polymorphisms associated with integrase inhibitor drug resistance in Estonian HIV-1 CRF06_cpx strains. 18th European Congress of Clinical Microbiology and Infectious Diseases; Barcelona; 19.04-22.04.2008.
 
Sadam, M.; Karki, T.; Huik, K.; Avi, R.; Rüütel, K.; Uusküla, A.; Lutsar, I (2008). CCL3L1 Variable Gene Copy Number Influence on the Susceptibility to HIV-1/AIDS Among Estonian Intravenous Drug User. The 15th Conference on Retroviruses and Opportunistic Infections (CROI), Boston, 03.02-06.02.2008.
21.03.2022

Kristi Huik

https://www.etis.ee/CV/Kristi_Huik/eng
30.08.1983
kristi.huik@ut.ee

Career

Institutions and positions
2020–...   
Clinical Retrovirology Section, HIV Dynamics and Replication Program, National Cancer Institute, National Institutes of Health, Special volunteer (0,10)
01.09.2020–31.12.2020   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Associate Professor in Medical Microbiology and Virology (1,00)
26.02.2018–31.08.2020   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Research Fellow of Medical Virology and Microbiology (0,25)
14.02.2018–26.08.2020   
Clinical Retrovirology Section, HIV Dynamics and Replication Program, National Cancer Institute, National Institutes of Health, Postdoctoral fellow (1,00)
01.01.2016–25.02.2018   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Research Fellow of Medical Virology and Microbiology (1,00)
01.09.2015–31.12.2015   
University of Tartu, Faculty of Medicine, Department of Microbiology, Research Fellow of Medical Virology and Microbiology (1,00)
01.06.2014–31.08.2015   
University of Tartu, Faculty of Medicine, Department of Microbiology, Research Fellow of Medical Virology (1,00)
01.03.2014–31.05.2014   
University of Tartu, Faculty of Medicine, Department of Microbiology, Junior Research Fellow of Medical Microbiology (1,00)
01.09.2013–28.02.2014   
University of Tartu, Faculty of Medicine, Department of Microbiology, Laboratory Assistant (1,00)
01.05.2006–31.08.2013   
University of Tartu, Faculty of Medicine, Department of Microbiology, Laboratory Assistant (0,50)
 
 
Education
2002–2007   
Tartu University, Faculty of Medicine, Pharmacy
 
 
R&D related managerial and administrative work
2010−...   
Council Member (Estonian representative) of European Society for translational Antiviral Research (ESAR)

Qualifications

Academic degrees
Kristi Huik, Doctor's Degree, 2014, (sup) Tõnis Karki; Irja Lutsar, The Influence of Host Genetic Factors on the Susceptibility to HIV and HCV Infections Among Intravenous Drug Users, University of Tartu, Faculty of Medicine.
Kristi Huik, Master's Degree, 2007, (sup) Tõnis Karki, HIV-1 subtüübiline jaotuvus Eestis (Distribution of HIV-1 in Estonia), University of Tartu, Faculty of Medicine, Department of Pharmacy.
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; SPECIFICATION: Influence of IH-virus tropism, human genetic factors and co-infections on the course of the disease
 
 

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

1.1. Teadusartiklid, mis on kajastatud Web of Science andmebaasides Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index ja/või andmebaasis Scopus (v.a. kogumikud)
 
Kõivumägi, K.; Geller, J.; Toompere, K.; Soeorg, H.; Kallas, E.; Jõegeda, E.-L.; Huik, K.; Lutsar, I. (2022). Norovirus strains among children aged 0-18 years hospitalized with acute gastroenteritis in Estonia 2015-2016. Journal of Medical Virology, 94 (6), 2632−2639. DOI: 10.1002/jmv.27495.
 
Kase, Kerstin; Avi, Radko; Toompere, Karolin; Rajasaar, Heli; Pauskar, Merit; Soodla, Pilleriin; Jogeda, Ene-Ly; Zilmer, Kai; Lutsar, Irja; Huik, Kristi (2021). Dynamics of hepatitis C epidemic among people living with HIV in Estonia based on Estonian HIV cohort study. BMC Infectious Diseases, 21 (1), ARTN 792. DOI: 10.1186/s12879-021-06521-w.
 
Koivumagi, Kadri; Soeorg, Hiie; Toompere, Karolin; Kallas, Eveli; Joegeda, Ene-Ly; Lass, Evely; Huik, Kristi; Lutsar, Irja (2021). Rotavirus Strain Surveillance in Estonia After Introduction of Rotavirus Universal Mass Vaccination. The Pediatric Infectious Disease Journal, 40 (5), 489−494. DOI: 10.1097/INF.0000000000003039.
 
Kõivumägi, Kadri; Toompere, Karolin; Soeorg, Hiie; Kallas, Eveli; Jõgeda, Ene-Ly; Huik, Kristi; Lutsar, Irja (2020). Acute gastroenteritis hospitalizations after implementation of universal mass vaccination against rotavirus. Vaccine, 38 (13), 2879−2886. DOI: 10.1016/j.vaccine.2020.01.098.
 
Sepp, Epp; Andreson, Reidar; Balode, Arta; Bilozor, Anastasia; Brauer, Age; Egorova, Svetlana; Huik, Kristi; Ivanova, Marina; Kaftyreva, Lidia; Kõljalg, Siiri; Koressaar, Triinu; Makarova, Maria; Miciuleviciene, Jolanta; Pai, Kristiine; Remm, Maido; Rööp, Tiiu; Naaber, Paul (2019). Phenotypic and Molecular Epidemiology of ESBL-, AmpC-, and Carbapenemase-Producing Escherichia coli in Northern and Eastern Europe. Frontiers in Microbiology, 10, ARTN 2465. DOI: 10.3389/fmicb.2019.02465.
 
Soodla, Pilleriin; Huik, Kristi; Pauskar, Merit; Cuypers, Lize; Van Laethem, Kristel; Rajasaar, Heli; Kallas, Eveli; Lepa, Helen; Velts-Lindh, Anna; Jogeda, Ene-Ly; Lutsar, Irja; Avi, Radko (2019). Stable level of HIV transmitted drug resistance in Estonia despite significant scale-up of antiretroviral therapy. Infection Genetics and Evolution, 75, ARTN 103901. DOI: 10.1016/j.meegid.2019.05.019.
 
Huik, Kristi; Soodla, Pilleriin; Pauskar, Merit; Owen, S. Michele; Luo, Wei; Murphy, Gary; Jogeda, Ene-Ly; Kallas, Eveli; Rajasaar, Heli; Avi, Radko; Masciotra, Silvina; Lutsar, Irja; Del Amo, Julia; Meyer, Laurence; Bucher, Heiner C.; Chene, Genevieve; Hamouda, Osamah; Pillay, Deenan; Prins, Maria; Rosinska, Magda ... Scott, Martin (2019). The concordance of the limiting antigen and the Bio-Rad avidity assays in persons from Estonia infected mainly with HIV-1 CRF06_cpx. PLoS ONE, 14 (5), ARTN e0217048. DOI: 10.1371/journal.pone.0217048.
 
Soodla, P.; Simmons, R.; Huik, K.; Pauskar, M.; Jõgeda, E.L.; Rajasaar, H.; Kallaste, E.; Maimets, M.; Avi, R.; Murphy, G.; Porter, K.; Lutsar, I.; Del Amo, J.; Meyer, L.; Bucher, H.C.; Chêne, G.; Hamouda, O.; Pillay, D.; Prins, M.; Rosinska, M. ... Rockstroh, J. (2018). HIV incidence in the Estonian population in 2013 determined using the HIV-1 limiting antigen avidity assay. HIV Medicine, 19 (1), 33−41. DOI: 10.1111/hiv.12535.
 
Jõgeda, E-L; Avi, R; Pauskar, M; Kallas, E; Karki, T; Des Jarlais, D; Uusküla, A; Toompere, K; Lutsar, I; Huik, K (2018). Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs. Journal of Medical Virology, 90 (11), 1779−1783. DOI: 10.1002/jmv.25258.
 
Jogeda, Ene-Ly; Huik, Kristi; Pauskar, Merit; Kallas, Eveli; Karki, Tonis; Jarlais, Don Des; Uuskula, Anneli; Lutsar, Irja; Avi, Radko (2017). Prevalence and Genotypes of GBV-C and Its Associations With HIV Infection Among Persons Who Inject Drugs in Eastern Europe. Journal of Medical Virology, 89 (4), 632−638. DOI: 10.1002/jmv.24683.
 
Soeorg, Hiie; Metsvaht, Tuuli; Eelmäe, Imbi; Merila, Mirjam; Treumuth, Sirli; Huik, Kristi; Jürna-Ellam, Marika; Ilmoja, Mari-Liis; Lutsar, Irja (2017). The role of breast milk in the colonization of neonatal gut and skin with coagulase-negative staphylococci. Pediatric Research, 82 (5), 759−767. DOI: 10.1038/pr.2017.150.
 
Soeorg, H.; Huik, K.; Parm, Ü.; Ilmoja, ML.; Metsvaht, T.; Lutsar, I. (2017). Molecular epidemiology of Staphylococcus epidermidis in neonatal intensive care units. APMIS, 125, 63−73. DOI: 10.1111/apm.12637.
 
Huik, Kristi; Avi, Radko; Pauskar, Merit; Kallas, Eveli; Jõgeda, Ene-Ly; Karki, Tõnis; Rüütel, Kristi; Talu, Ave; Abel-Ollo, Katri; Uusküla, Anneli; Carrillo, Andrew; Ahuja, Sunil K; He, Weijing; Lutsar, Irja (2016). A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. PLoS ONE, 11 (6), e0156850−e0156850. DOI: 10.1371/journal.pone.0156850.
 
Avi, Radko; Pauskar, Merit; Karki, Tõnis; Kallas, Eveli; Jõgeda, Ene-Ly; Margus, Tõnu; Huik, Kristi; Lutsar, Irja (2016). Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia. Journal of Medical Virology, 88 (3), 448−454. DOI: 10.1002/jmv.24361.
 
Kallas, Eveli; Huik, Kristi; Türk, Silver; Pauskar, Merit; Jõgeda, Ene-Ly; Šunina, Marina; Karki, Tõnis; Des Jarlais, Don; Uusküla, Anneli; Avi, Radko; Lutsar, Irja (2016). T Cell Distribution in Relation to HIV/HBV/HCV Coinfections and Intravenous Drug Use. Viral Immunology, 0−0. DOI: 10.1089/vim.2016.0057.
 
Kallas, Eveli; Huik, Kristi; Türk, Silver; Pauskar, Merit; Jõgeda, Ene-Ly; Šunina, Marina; Karki, Tõnis; Des Jarlais, Don; Uusküla, Anneli; Avi, Radko; Lutsar, Irja (2016). Differences in T cell distribution and CCR5 expression in HIV-positive and HIV-exposed seronegative persons who inject drugs. Medical Microbiology and Immunology, 205 (3), 231−239. DOI: 10.1007/s00430-015-0444-8.
 
Jõgeda, Ene-Ly; Avi, Radko; Pauskar, Merit; Kallas, Eveli; Karki, Tõnis; Des Jarlais, Don; Uusküla, Anneli; Lutsar, Irja; Huik, Kristi (2016). Human T-lymphotropic virus types 1 and 2 are rare among intravenous drug users in Eastern Europe. Infection Genetics and Evolution, 43, 83−85. DOI: 10.1016/j.meegid.2016.05.022.
 
Koljalg, Siiri; Telling, Kaidi; Huik, Kristi; Murruste, Marko; Saarevet, Virve; Pauskar, Merit; Lutsar, Irja (2015). First report of Wohlfahrtiimonas chitiniclastica from soft tissue and bone infection at an unusually high northern latitude. Folia Microbiologica, 60 (2), 155−158. DOI: 10.1007/s12223-014-0355-x.
 
Kallas, E.; Huik, K.; Pauskar, M.; Jõgeda, E.-L.; Karki, T.; Des Jarlais, D.; Uusküla, A.; Avi, R.; Lutsar, I. (2015). Influence of interleukin 10 polymorphisms -592 and -1082 to the HIV, HBV and HCV serostatus among intravenous drug users. Infection Genetics and Evolution, 30, 175−180. DOI: 10.1016/j.meegid.2014.12.023.
 
Soodla, P.; Rajasaar, H.; Avi, R.; Zilmer, K.; Kink, K.; Novikova, L.; Huik, K.; Maimets, M.; Lutsar, I. (2015). Design and structure of the Estonian HIV Cohort Study (E-HIV). Infectious Diseases, 47 (11), 768−675. DOI: 10.3109/23744235.2015.1061203.
 
Lillo, Jana; Pai, Kristiine; Bolde, Arta; Makarova, Mariia; Huik, Kristi; Kõljalg, Siiri; Ivanova, Marina; Kaftyreva, Lidia; Miciuleviciene, Jolanata; Naaber, Paul; Parv, Kristel; Pavelkovich, Anastasia; Rööp, Tiiu; Toompere, Karolin; Suzhaeva, Ludmila; Sepp, Epp (2014). Differences in extended-spectrum beta-lactamase producing Escherichia coli virulence factor genes in the Baltic Sea region. BioMed Research International, 427254, 1−7. DOI: 10.1155/2014/427254.
 
Huik, K.; Avi, R.; Uibopuu, H.; Pauskar, M.; Margus, T.; Karki, T.; Krispin, T.; Kool, P.; Rüütel, K.; Talu, A.; Abel-Ollo, K.; Uusküla, A.; Carrillo, AQ.; He, W.; Ahuja, SK.; Lutsar, I. (2014). Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 66 (3), 239−244. DOI: 10.1097/QAI.0000000000000127.
 
Avi, R; Huik, K; Pauskar, M; Ustina, V; Karki, T; Kallas, E; Jõgeda, EL; Krispin, T; Lutsar, I (2014). Transmitted drug resistance is still low in newly diagnosed human immunodeficiency virus type 1 CRF06_cpx-infected patients in Estonia in 2010. Aids Research and Human Retroviruses, 30 (3), 278−283. DOI: 10.1089/aid.2012.0357.
 
Huik, K; Avi, R; Pauskar, M; Kallas, E; Jõgeda, EL; Karki, T; Marsh, K; Des Jarlais, D; Uusküla, A; Lutsar, I (2013). Association between TLR3 rs3775291 and resistance to HIV among highly exposed Caucasian intravenous drug users. Infection Genetics and Evolution, 20, 78−82. DOI: 10.1016/j.meegid.2013.08.008.
 
Huik, K; Avi, R; Carrillo, A; Harper, N; Pauskar, M; Sadam, M; Karki, T; Krispin, T; He, W; Lutsar, I (2013). CCR5 Haplotypes Influence HCV Serostatus in Caucasian Intravenous Drug Users. PLoS ONE, 8 (7), e70561. DOI: 10.1371/journal.pone.0070561.
 
Soeorg, H.; Huik, K.; Parm, U.; Ilmoja, ML.; Metelskaja, N.; Metsvaht, T.; Lutsar, I. (2013). Genetic Relatedness of Coagulase-Negative Staphylococci from Gastrointestinal Tract and Blood of Preterm Neonates with Late-Onset Sepsis. The Pediatric Infectious Disease Journal, 32 (4), 389−393. DOI: 10.1097/INF.0b013e3182791abd.
 
Soeorg, H.; Tamm, E.; Huik, K.; Pauskar, M.; Mägi, D.; Pruudel, K.; Vainomäe, L.; Moosar, L.; Kirss, K.; Torm, S.; Närska, M.; Pütsepp, A.; Nurm, H.; Pruunsild, K.; Jänes, A.; Zilmer, K.; Lutsar, I. (2012). Group A rotavirus genotypes circulating prior to implementation of a National Immunization Program in Estonia. Human Vaccines, 8 (4), 465−469. DOI: 10.4161/hv.19135.
 
Avi, R; Huik, K; Pauskar, M; Ustina, V; Karki, T; Krispin, T; Ainsalu, K; Paap, P; Schmidt, J; Nikitina, N; Lutsar, I. (2011). Emerging Transmitted Drug Resistance in Treatment Naive Human Immunodeficiency Virus - 1 CRF06_cpx Infected Patients in Estonia. Scandinavian Journal of Infectious Diseases, 43 (2), 122−128.
 
Avi, R.; Huik, K.; Sadam, M.; Karki, T.; Krispin, T.; Ainsalu, K.; Paap, P.; Schmidt, J.; Nikitina, N.; Lutsar, I. (2010). Characterization of Integrase Region Polymorphisms in HIV-1 CRF06_cpx Viruses in Treatment Naïve Patients in Estonia. Aids Research and Human Retroviruses, 26 (10), 1109−1113. DOI: 10.1089/aid.2010.0097.
 
Huik, K.; Sadam, M.; Karki, T.; Avi, R.; Krispin, T.; Paap, P.; Rüütel, K.; Uusküla, A.; Talu, A.; Abel-Ollo, K.; Lutsar, I. (2010). CCL3L1 copy number is a strong genetic determinant of HIV seropositivity in Caucasian intravenous drug users. The Journal of Infectious Diseases, 730−739. DOI: 10.1086/650491.
 
Avi, R; Huik, K; Sadam, M; Karki, T; Krispin, T; Ainsalu, K; Paap, P; Schmidt, J; Nikitina, N; Lutsar, I. (2009). Absence of Genotypic Drug Resistance and Presence of Several Naturally Occurring Polymorphisms of Human Immunodeficiency Virus-1 CRF06_cpx in Treatment-Naive Patients in Estonia. Journal of Medical Virology, 81 (6), 953−958. DOI: 10.1002/jmv.21482.
1.3. Eelretsenseeritud teadusartiklid Eesti ja teiste riikide eelretsenseeritavates teadusajakirjades, millel on kohalik toimetuskolleegium, või eelretsenseeritud teadusartiklid Eesti kultuurile olulistes ajakirjades või teadusartiklid ajakirjades Akadeemia, Looming ja Vikerkaar.
 
Irja Lutsar, Radko Avi, Pilleriin Soodla, Kristi Huik, Karolin Toompere, Margus Jääger, Kersti Kink, Kaisa Kirs, Heli Rajasaar, Svetlana Semjonova, Kai Zilmer (2018). UNAIDSi kriteeriumid HIV-infektsiooni monitoorimiseks: olukord Eestis 2017. aastal E-HIVi põhjal. Eesti Arst, 97 (10), 527−534.
2.4. Kõrgkooliõpikud
 
Merits, Andres; Abroi, Aare; Kurg, Reet; Žusinaite, Eva; Truve, Erkki; Sarmiento, Cecilia; Sõmera, Merike; Saar, Tiiu; Viltrop, Arvo; Lutsar, Irja; Avi, Radko; Karki, Tõnis; Huik, Kristi; Kõljalg, Siiri; Brilene, Tatjana; Roots, Irja;Inno, Heleri (2022). Üldine ja Meditsiiniline viroloogia. Tartu: Tartu Ülikooli kirjastus [ilmumas].
3.5. Artiklid/ettekanded, mis on avaldatud kohalikes konverentsikogumikes
 
Tamman, S; Denks, K; Huik, K; Parm, Ü; Avi, R; Lutsar, I. (2008). Klebsiella pneumoniae genotüpiseerimine multiensüüm-multipleks amplified fragmrnt length polymorphism PCR (AFLP-PCR) meetodil. Eesti Arst.
5.1. Konverentsiteesid, mida kajastab Thomson Reuters Web of Science
 
Denks, K.; Huik, K.; Avi, R.; Sadam, M.; Krispin, T.; Lutsar, I. (2007). GB virus C infection among HIV-positive patients in Estonia. International Journal of Antimicrobial Agents, 29 (3), S155−S155.
 
Avi, R.; Huik, K.; Karki, T.; Sadam, M.; Paap, P.; Smidt, J.; Ainsalu, K.; Krispin, T.; Lutsar, I (2007). The coexistence of secondary PR mutations M36I, K20I and L63H predominates in CRF06_cpx and its next generation recombinant virusese circulating in Estonian treatment naive patients. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 29. , S549−S549.
5.2. Konverentsiteesid, mis ei kuulu valdkonda 5.1
 
Huik, Kristi; Virga, James; Ganesan, Anuradha; McMahon, Deborah; Utay, Netanya; Rehm, Catherine; Bell, Jennifer; Maldarelli, Frank (2020). Changes in Gut Microbiome in HIV-Infected Individuals Undergoing Long Term Antiretroviral Therapy Receiving Rifaximin: Results of the GUTCHEK Study. In: . International Workshop on Microbiome in HIV Pathogenesis, Prevention and Treatment 2020. International Workshop on Microbiome in HIV Pathogenesis, Prevention and Treatment 2020.
 
Kallas, E.; Avi, R.; Huik, K.; Türk, S.; Pauskar, M.; Jõgeda, E.-.L.; Šunina, M.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2015). The distribution of TEMRA cells is influenced by HIV, HBV, HCV infections and intravenous drug use. 25th European Congress of Clinical Microbiology and Infectious Diseases; Copenhagen, Denmark, 25.-28. April 2015.
 
Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. (2015). Molecular epidemiology of Staphylococcus epidermidis colonizing gastrointestinal tract of neonates hospitalized to intensive care unit. The 25th European Congress of Clinical Microbiology and Infectious Diseases, April 25-28, 2015, Copenhagen, Denmark..
 
Naaber, Paul; Balode, Arta; Egorova, Svetlana; Huik, Kristi; Ivanova, Marina; Kaftyreva, Lidia; Kõljalg, Siiri; Kõressaar, Triinu; Lillo, Jana; Löhr, Iren; Miciuleviciene, Jolanta; Pai, Kristiine; Pavelkovich, Anastassia; Remm, Maido; Sepp, Epp (2015). The epidemiology of CTX-M group genes among clinical Escherichia coli strains in Estonia, Latvia, Lithuania, Norway and Russia.
 
Jõgeda, Ene-Ly; Avi, Radko; Pauskar, Merit; Kallas, Eveli; Karki, Tõnis; Jarlais, Don Des; Uusküla, Anneli; Lutsar, Irja; Huik, Kristi; (2015). HTLV-1/2 is rare among Eastern-European intravenous drug users (IDUs). Retrovirology, 12, P79−P79. DOI: doi.org/10.1186/1742-4690-12-S1-P79.
 
Soeorg, H.; Huik, K.; Parm, Ü.; Ilmoja, ML.; Metsvaht, T.; Lutsar, I. (2014). Virulentsus- ja resistentsusgeenide varieeruvus lasteintensiivravi osakondades levivate Staphylococcus epidermidis’te hulgas. Eesti Arst, 24−24. (93; Lisa 1).
 
Pai, K.; Huik, K.; Ivanova, M.; Kõljalg, S.; Pavelkovich, K.; Parv, K.; Rööp, T.; Sepp, E.; Naaber, P. (2014). Detection and molecular characterisation of extended-spectrum beta-lactamase-producing Escherichia coli sequence type ST131 from the Baltic region. European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, Spain, 10-13 May 2014.
 
Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. (2014). Genetic variation of virulence and resistance genes in Staphylococcus epidermidis circulating in neonatal intensive care units. The 24th European Congress of Clinical Microbiology and Infectious Diseases, May 10-13, 2014, Barcelona, Spain..
 
Avi, R.; Huik, K.; Pauskar, M.; Kallas, E.; Jõgeda, E.-L.; Zilmer, K.; Ustina, V.; Novikova, L.; Karki, T.; Kisand, V.; Lutsar, I. (2014). Full-Length Genome Sequences of Estonian HIV-1 CRF06 and Eastern-European Subtype A1 Recombinant Forms. 7th National Congress HIV/AIDS and the 2nd Central European HIV Forum, Sibiu, Romania, 29-31 May 2014.
 
Pauskar, M.; Huik, K.; Avi, R.; Kallas, E.; Jõgeda, E.-L.; Karki, T.; Semjonova, S.; Smidt, J.; Novikova, L.; Ainsalu, K.; Lutsar, I. (2014). Antiretroviral drug resistance and viral tropism in HIV-1 CRF06_cpx infected patients failing antiretroviral (ARV) therapy. 7th National Congress HIV/AIDS and the 2nd Central European HIV Forum, Sibiu, Romania, 29-31 May 2014.
 
Kallas, E.; Huik, K.; Avi, R; Pauskar, M.; Jõgeda, E.-L.; Karki, T.; Marsh, K.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2014). NLRP3 genotype CG increases the risk of HIV-1 in Caucasian intravenous drug users (IDUs). European Human Genetics Conference 2014, Milan, Italy, 31 May-3 June 2014.
 
Jõgeda, E.-L.; Huik, K.; Avi, R; Pauskar, M., Kallas, E.; Karki, T.; Marsh, K.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2014). Associations between MX2 polymorphism and the acquisition of HIV and co-infections in Caucasian intravenous drug users (IDUs). European Human Genetics Conference 2014, Milan, Italy, 31 May-3 June 2014.
 
Kallas, E.; Avi, R.; Huik, K.; Türk, S.; Pauskar, M.; Jõgeda, E.-.L.; Šunina, M.; Des Jarlais, D.; Uusküla, A.; Lutsar, I. (2014). Injection drug use influences T-cell distribution and CCR5 expression in HIV+ and ESN population. 24th European Congress of Clinical Microbiology and Infectious Diseases; Barcelona; 10-13 May 2014.
 
Soeorg H, Huik K, Parm Ü, Ilmoja ML, Metsvaht T, Lutsar I. (2014). Vancomycin-heteroresistance in Staphylococcus epidermidis colonizing neonates in neonatal intensive care units. The 32nd Annual Meeting of the European Society for Paediatric Infectious Diseases, May 6-10, 2014, Dublin, Ireland..
 
Avi, Radko; Huik, Kristi; Pauskar, Merit; Kallas, Eveli; Jõgeda, Ene-Ly; Karki, Tõnis; Šmidt, Jelena; Novikova, Lilia; Semjonova, Svetlana; Lutsar, Irja. (2013). Substitutions in RNaseH and Connection domain of HIV-1 CRF06_cpx viruses in treatment naive and treatment experienced populations. 11th European Meeting on HIV & Hepatitis- Treatment Strategies & Antiviral Drug Resistance; Rome; 20-22 March 2013. , 35−35.
 
Jõgeda, Ene-Ly; Huik, Kristi; Pauskar, Merit; Kallas, Eveli; Krispin, Tõnu; Karki, Tõnis; Marsh, Kristina; Des Jarlais, Don; Uusküla, Anneli; Avi, Radko; Lutsar, Irja. (2013). The prevalence of GBV-C and its associations with HIV infection among Estonian intravenous drug users. Reviews in Antiviral Therapy Infectious Diseases: 11th European Meeting on HIV & Hepatitis- Treatment Strategies & Antiviral Drug Resistance; Rome; 20-22 March 2013. , 46−47.
 
Kallas, Eveli; Huik, Kristi; Av1, Radko; Pauskar, Merit; Jõgeda, Ene-Ly; Karki, Tõnis; Marsh, Kristina; Des Jarlais, Don; Uusküla, Anneli; Lutsar, Irja (2013). The IL-10 promoter genotype AA at -592 is correlated with increased susceptibility to hepatitis B but not HIV infection in Caucasian intravenous drug users. European Human Genetics Conference 2013, Paris, France, 8.06.13-11.06.13.
 
Lillo, J; Balode, A; Egorova, S; Huik, K; Ivanova, M; Kaftyreva, L; Makarova, M; Miciuleviciene, J; Naaber, P; Pai, K; Parv, K; Pavelkovich, A; Rööp, T; Sepp, E. (2013). Differences in virulence factors of Escherichia coli isolated from the Baltic Sea region. 23 nd European Congress ofClinical Microbiology and Infectious Diseases; Berlin; 27-30 April 2013.
 
Naaber, P; Balode, A; Djundika, T; Egorova, S; Huik, K; Kaftyreva, L; Kamõnina, N; Kirs, K; Kõljalg, S; Konovalenko, I; Kurchikova, T; Lillo, J; Lipskaya, L; Lõivukene, L; Makarova, M; Makstutis, G; Miciuleviciene, J; Morozova, O; Pai, K; Parv, K ... Ivanova, M (2013). Epidemiology of extended-spectrum beta-lactamases-producing Escherichia coli and Klebsiella pneumoniae in the Baltic Sea region. 23 nd European Congress ofClinical Microbiology and Infectious Diseases; Berlin; 27-30 April 2013.
 
Pai, K; Balode, B; Egorova, S; Huik, K; Ivanova, M; Kaftyreva, L; Kõljalg, S; Lillo, J; Miciuleviciene, J; Naaber, P; Parv, K; Pavelkovich, A; Rööp, T; Sepp, E. (2013). The molecular epidemiology of extended-spectrum beta-lactamases-producing Escherichia coli and Klebsiella pneumoniae in the Baltic Sea region. 23 nd European Congress ofClinical Microbiology and Infectious Diseases; Berlin; 27-30 April 2013.
 
Avi, R.; Huik, K.; Pauskar, M., Lutsar, I.; Vandamme, A.; Abecasis, A. (2012). The population dynamics of the HIV-1 epidemic in Estonia through virus genetic analysis and national case recording. 17th International BioInformatics Workshop on Virus Evolution and Molecular Epidemiology, 27-31 August 2012 Belgrade Serbia.
 
Uibopuu, H.; Huik, K.; Avi, R.; Pauskar, M.; Kallas, E.; Karki, T.; Krispin, T.; Kool, P.; Schmidt, J.; Rüütel, K.; Talu, A.; Abel-Ollo, K.; Uusküla, A.; Lutsar, I. (2012). Viral tropism of HIV-1 CRF06_cpx and its association with CCR5 haplotypes. 10th European Meeting on HIV & Hepatitis - Treatment Strategies & Antiviral Drug Resistance, 28 - 30 March 2012 Barcelona Spain.
 
Pauskar, M.; Avi, R.; Huik, K.; Ustina, V.; Jõgeda, E.; Kallas, E.; Karki, T.; Krispin, T.; Lutsar, I. (2012). Transmitted drug resistance is 4.5% in newly diagnosed mainly HIV-1 CRF06_cpx infected patients in Estonia in 2010. 10th European Meeting on HIV & Hepatitis - Treatment Strategies & Antiviral Drug Resistance, 28 - 30 March 2012 Barcelona Spain.
 
Avi, R.; Huik, K.; Pauskar, M.; Kallas, E.; Karki, T.; Krispin, T.; Ainsalu, K.; Semjonova, S.; Kool, P.; Novikova, L.; Schmidt, J.; Lutsar, I. (2012). The pattern of drug resistance mutations in HIV-1 CRF06_cpx viruses failing the first-line NNRTI+2NRTI antiretroviral therapy. 10th European Meeting on HIV & Hepatitis - Treatment Strategies & Antiviral Drug Resistance, 28 - 30 March 2012 Barcelona Spain.
 
Kallas, E.; Avi, R.; Huik, K.; Pauskar, M.; Ustina, V.; Karki, T.; Krispin, T.; Ainsalu, K.; Semjonova, S.; Kool, P.; Novikova, L.; Schmidt, J.; Lutsar, I. (2012). HIV Type-1 CRF06_cpx P(T/S)AP Late Domain duplications are outselected among treatment experienced compared to treatment naïve patients. Reviews in Antiviral Therapy & Infectious Diseases. .
 
Soeorg, Hiie; Huik, Kristi; Štšepetova, Jelena; Truusalu, Kai; Pauskar, Merit; Parm, Ülle; Ilmoja, Mari-Liis; Metsvaht, Tuuli; Lutsar, Irja (2012). Genetic relatedness of coagulase-negative staphylococci (CoNS) from gastrointestinal tract (GIT) and blood of neonates with late-onset sepsis (LOS). The 30th Annual Meeting of the European Society for Paediatric Infectious Diseases, May 8-12, 2012, Thessaloniki, Greece..
 
Soeorg H, Huik K, Pauskar M, Tamm E, et al. (2011). Molecular epidemiology of Rotaviruses in Estonia in 2007-2008. The 29th Annual Meeting of the European Society for Paediatric Infectious Diseases, June 7-11, 2011, The Hague, the Nertherlands..
 
Huik, Kristi; Parm, Ülle; Denks, Kärt; Pauskar, Merit; Lutsar, Irja. (2010). magA, k2A, rmpA and kfu genes are not related to onset neonatal sepsis of Klebsiella pneumoniae in neonatal intensive care units in two major hospitals in Estonia. European Congress of Clinical Microbiology and Infectious Diseases, Vienna 2010..
 
Huik, K.; Avi, R.; Sadam, M.; Karki, T.; Denks, K.; Krispin, T.; Ustina, V.; Rüütel, K.; Uusküla, A.; Murphy, G.; Lutsar, I. (2009). Performance of the BED-CEIA in population infected with HIV1 recombinant viruses CRF06cpx and CRF06A. Clinical Microbiology and Infection: 19th European Congress of Clinical Microbiology and Infectious Diseases Helsinki, Finland, 16 - 19 May 2009.
 
Huik, K.; Avi, R.; Sadam, M.; Karki, T.; Albert, J.; Lutsar, I. (2008). Drug Resistance Mutations in HIV-1 CRF06_cpx Viruses Isolated from Treatment Naïve and Experienced Patients. European Journal of Medical Research: 19th European Students’ Conference; Berlin; 28 September - 3 October 2008.
 
Avi, R.; Huik, K.; Karki, T.; Sadam, M.; Krispin, T.; Ainsalu, K.; Paap, P.; Schmidt, J.; Nikitina, N.; Lutsar, I. (2008). Drug Resistance Mutations and Genetic Barrier for Drug Resistance Development in Estonian HIV-1 CRF06_cpx Integrase Sequences. 14th International Bioinformatics Workshop on Virus Evolution and Molecular Epidemiology; Cape Town, South Africa; 1-5 September 2008.
 
Avi, R.; Huik, K.; Sadam, M.; Karki, T.; Krispin, T.; Paap, P.; Ainsalu, K.; Schmidt, J.; Nikitina, N.; Lutsar, I. (2008). Natural polymorphisms associated with integrase inhibitor drug resistance in Estonian HIV-1 CRF06_cpx strains. 18th European Congress of Clinical Microbiology and Infectious Diseases; Barcelona; 19.04-22.04.2008.
 
Sadam, M.; Karki, T.; Huik, K.; Avi, R.; Rüütel, K.; Uusküla, A.; Lutsar, I (2008). CCL3L1 Variable Gene Copy Number Influence on the Susceptibility to HIV-1/AIDS Among Estonian Intravenous Drug User. The 15th Conference on Retroviruses and Opportunistic Infections (CROI), Boston, 03.02-06.02.2008.
21.03.2022