See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Lauri Vares

https://www.etis.ee/CV/Lauri_Vares/est
27.03.1973
737 4808
lauri.vares@ut.ee

Teenistuskäik

Töökohad ja ametid
19.02.2016–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, orgaanilise keemia vanemteadur (1,00)
01.01.2014–31.12.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (1,00)
01.05.2013–31.12.2013   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (1,00)
01.10.2011–30.04.2013   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (1,00)
01.04.2011–30.09.2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (0,90)
01.01.2011–31.03.2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (0,20)
15.11.2010–31.12.2010   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (0,20)
01.01.2008–14.11.2010   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (1,00)
01.01.2006–31.12.2007   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, orgaanilise keemia vanemteadur (1,00)
01.01.2005–31.12.2005   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, erakorraline vanemteadur (1,00)
 
 
Haridustee
1998–1998   
Notre Dame Ülikool, USA
1996–1998   
Taani Tehnikaülikool
1996–1996   
Kuninglik Tehnoloogiainstituut (Rootsi), litsensiaadi kraad
1991–1996   
Tallinna Tehnikaülikool, lõpetanud keemiainsenerina.
1980–1991   
Tallinna Reaalkool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2010−...   
Ravimiameti ekspert
2007−2012   
Tehnoloogiainstituudi nõukogu ja valitsuse liige
2006−2012   
Tehnoloogiainstituudi keemia arenduskeskuse juht
 
 
Lisainfo
Jaan. 2002 kuni dets. 2004 AstraZeneca R&D, keemia osakond, Södertälje, Rootsi. Vanemteadur;
Järeldoktor USA-s Notre Dame Ülikoolis, 2000-2001, juhendaja prof. Bradley D. Smith;

Kvalifikatsioon

Teaduskraadid
Lauri Vares, doktorikraad, 2000, (juh) Tobias Rein, Stereoselective Synthesis of Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Asymmetric Horner-Wadsworth-Emmons and Ring Closure Reactions (Tetrahüdrofuraanide ja tetrahüdropüraanide stereoselektiivne süntees kasutades asümmeetrilist Horner-Wadsworth-Emmons ja tsükliseerimise reaktsioone), Tartu Ülikool.
 
 
Teaduspreemiad ja tunnustused
1996, Lauri Vares, Minu Tallinna Tehnikaülikoolis sooritatud diplomitöö võitis esimese preemia üliõpilaste teadustööde kunkursil Eestis 1996-ndal aastal.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 4. Loodusteadused ja tehnika; 4.11. Keemia ja keemiatehnika; CERCS KLASSIFIKAATOR: P390 Orgaaniline keemia ; TÄPSUSTUS: Roheline keemia
ETIS KLASSIFIKAATOR: 4. Loodusteadused ja tehnika; 4.11. Keemia ja keemiatehnika; CERCS KLASSIFIKAATOR: P390 Orgaaniline keemia ; TÄPSUSTUS: Uued meetodid asümmeetriliseks sünteesiks
 
 
Lisainfo
Tehnoloogia väljatöötamine uut tüüpi teise põlvkonna biokütuse saamiseks. Energiatehnoloogia grant 2011-2015
Uudsed biotoormel põhinevad pakendid, 2017-2019
Tartu Ülikooli baasfinantseerimise grant 2005-2007 "Bioaktiivsete atsetogeniini analoogide süntees ning nende bioloogiliste ja füüsikaliste omaduste uurimine"
ETF grant 2000-2001 "Uued meetodid tetrahüdropuraanide ja tetrahüdrofuraanide asümeetriliseks sünteesiks ning nende meetodite rakendamine atsetogeniinide sünteesis"
Stipendium Salén’i fondilt (Rootsis) aastal 1998
Põhjamaade Ministrite Nõukogu stipendium (Taanis) aastal 1998
Stipendium Rootsi Instituudilt aastal 1997
Axel ja Margret Johnson’i fondi stipendium (Rootsis) aastal 1996
Bioaktiivsete ainete Tehnoloogia Tehnoloogiainstituudis: õppe- ja teadustöö kvaliteedi tõstmine Tartu Ülikooli Tehnoloogiainstituudis (BaTT). Euroopa Sotsiaalfindi grant 2007-2008

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Moreno, Adrian; Bensabeh, Nabil; Parve, Jaan; Ronda, Juan Carlos; Cadiz, Virginia; Galia, Marina; Vares, Lauri; Lligadas, Gerard; Percec, Virgil (2019). SET-LRP of Bio- and Petroleum-Sourced Methacrylates in Aqueous Alcoholic Mixtures. Biomacromolecules, 20, 1816−1827.10.1021/acs.biomac.9b00257.
1.1.
2018
Bredihhin, Aleksei; Salmer, Siim; Vares, Lauri (2018). A route for conversion of furfural to ethylcyclopentane. ACS Omega, 3 (8), 10211−10215.10.1021/acsomega.8b00588.
1.1.
2018
Matt, L.; Parve, J.; Parve, O.; Pehk, T.; Pham, T. H.; Liblikas, I.; Vares, L.; Jannasch, P. (2018).

Enzymatic Synthesis and Polymerization of Isosorbide-Based Monomethacrylates for High-Tg Plastics

. ACS Sustainable Chemistry & Engineering, 6 (12), 17382−17390.10.1021/acssuschemeng.8b05074.
5.2.
2018
Matt, L.; Parve, O.; Parve, J.; Pehk, T.; Vares, L.; Jannasch, P. (2018). Biocatalytic synthesis and polymerization of isosorbide-based monomethacrylates. 3rd Green & Sustainable Chemistry; Berlin, Germany; 13.-16. May 2018. Elsevier,.
3.1.
2017
Bredihhin, A.; Vares, L. (2017). Conversion of Biomass to Biofuels. In: Zerong Wang (_EditorsAbbr). Encyclopedia of Physical Organic Chemistry, 6 Volume Set (3653−3697). John Wiley & Sons Ltd.10.1002/9781118468586.
5.2.
2017
Matt, L.; Villo, P.; Toom, L.; Liblikas, I.; Pehk, T.; Vares, L. (2017). Hydroformylation of biomass-based olefinic derivatives of Isosorbide. Renewable plant resources: chemistry, technology, medicine; Saint Petersburg, Russia; 18-22. September 2017. Saint Petersburg: VVM Publishing, 60.
1.1.
2016
Bredihhin, Aleksei; Luiga, Sirvo; Vares, Lauri. (2016). Application of 5-ethoxymethylfurfural (EMF) for the production of cyclopentenones. Synthesis, 48 (23), 4181−4188.10.1055/s-0035-1562790.
1.1.
2016
Villo, P.; Matt, L.; Toom, L.; Liblikas, I.; Pehk, T.; Vares, L. (2016). Hydroformylation of Olefinic Derivatives of Isosorbide and Isomannide. Journal of Organic Chemistry, 81 (17), 7510−7517.10.1021/acs.joc.6b01179.
3.1.
2016
Parve, Jaan; Vares, Lauri; Reile, Indrek; Pehk, Tõnis; Villo, Ly; Parve, Omar (2016). Catalyzed Resolution and Simultaneous Selective Crystallization. In: Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén (Ed.). Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (931−934). London: Royal Soc Chemistry.
1.1.
2015
Parve, J.; Reile, I.; Aid, T.; Kudrjašova, M.; Müürisepp, A.-M.; Vallikivi, I.; Villo, L.; Aav, R.; Pehk, T.; Vares, L.; Parve, O. (2015). Lipase-catalyzed stereoresolution of long-chain 1,2-alkanediols: a screening of preferable reaction conditions. Journal of Molecular Catalysis B: Enzymatic, 116, 60−69.10.1016/j.molcatb.2015.03.006.
3.1.
2015
Bredihhin, A.; Vares, L. (2015). Liquid Biofuels Usable in Motorized Transport. In: J.N. Govil (_EditorsAbbr). Energy Science and Technology, 12 Volume Set. Vol. 7: Bioenergy (310−331). Studium Press LLC.
1.1.
2014
Veidenberg, I.; Toom, L.; Villo, P.; Vares, L. (2014). An efficient and highly stereoselective approach to trans-2,5-disubstituted-tetrahydrofuran and trans-2,6-disubstituted-tetrahydropyran derivatives. Tetrahedron Letters, 55 (25), 3569−3571.10.1016/j.tetlet.2014.04.109.
1.1.
2014
Viil, I.; Bredihhin, A.; Mäeorg, U.; Vares, L. (2014). Preparation of potential biofuel 5-ethoxymethylfurfural and other 5-alkoxymethylfurfurals in the presence of oil shale ash. RSC Advances, 4 (11), 5689−5693.10.1039/C3RA46570E.
1.1.
2013
Parve, O.; Reile, I.; Parve, J.; Kasvandik, S.; Kudrjashova, M.; Tamp, S.; Metsala, A.; Villo, L.; Pehk, T.; Jarvet, J.; Vares, L. (2013). An NMR and MD Modeling Insight into Nucleation of 1,2-Alkanediols; Selective Crystallization of Lipase-Catalytically Resolved Enantiomers from the Reaction Mixtures. Journal of Organic Chemistry, 78 (24), 12795−12801.10.1021/jo402189e.
1.1.
2013
Villo, Piret; Toom, Lauri; Eriste, Elo; Vares, Lauri (2013). Synthesis of Linear Aza and Thio Analogues of Acetogenins and Evaluation of Their Cytotoxicity. European Journal of Organic Chemistry, 2013 (30), 6886−6899.10.1002/ejoc.201300767.
1.1.
2013
Karlström, Sofia; Nordvall, Gunnar; Sohn, Daniel; Hettman, Andreas; Turek, Dominika; Åhlin, Kristofer; Kers, Annika; Claesson, Martina; Slivo, Can; Lo-Alfredsson, Yvonne; Petersson, Carl; Bessidskaia, Galina; Svensson, Per H.; Rein, Tobias; Jerning, Eva; Malmberg, Åsa; Ahlgen, Charlotte; Ray, Colin; Vares, Lauri; Ivanov, Vladimir ... Johansson, Rolf (2013). Substituted 7‑Amino-5-thio-thiazolo[4,5‑d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1). Journal of Medicinal Chemistry, 56 (8), 3177−3190.10.1021/jm3012273.
1.1.
2013
Doyle, E.; Parve, J.; Kudryashova, M.; Tamp, S.; Müürisepp, A.-M.; Villo, L.; Vares, L.; Pehk, T.; Parve, O. (2013). Synthesis and Quantitative Analysis of Diastereomeric Linked Ester Conjugates with Remote Stereocenters Using High Field NMR and Chiral HPLC. Chirality, 25 (11), 793−798.10.1002/chir.22217.
1.1.
2013
Bredihhin, A.; Mäeorg, U.; Vares, L. (2013). Evaluation of carbohydrates and lignocellulosic biomass from different wood species as raw material for the synthesis of 5-bromomethyfurfural. Carbohydrate Research, 375, 63−67.10.1016/j.carres.2013.04.002.
1.1.
2013
Bredihhina, J.; Villo, P.; Andersons, K.; Toom, L.; Vares, L. (2013). Hydrolytic and Aminolytic Kinetic Resolution of Terminal Bis-Epoxides. Journal of Organic Chemistry, 78 (6), 2379−2385.10.1021/jo3024335.
5.2.
2013
Villo, Piret; Toom, Lauri; Vares, Lauri (2013). Synthesis of Aza- and Thio-Analogues of Acetogenins. Abstracts: Komppa Symposium, Aalto University, Espoo, Finland, 24.-26.06.2013.
1.1.
2012
Remmel, I.; Vares, Lauri; Toom, Lauri; Matto, Vallo; Raal, Ain (2012). Phenolic compounds in five Epilobium species collected from Estonia. Natural Product Communications, 7 (10), 1323−1324.
5.2.
2012
Veskilt, E.; Tamp, S.; Parve, J.; Vares, L.; Pehk, T.; Villo, L.; Parve, O. (2012). O-Alkylation of hydroxycarboxylic acids with (-)-menthyl bromoacetate affords bridged diastereomeric esters. Balticum Organicum Syntheticum, Tallinn 2012.
5.2.
2012
Villo, Piret; Bredihhina, Jevgenia; Andersons, Karlis; Vares, Lauri. (2012). Hydrolytic Kinetic Resolution of Terminal Diepoxides in the Synthesis of Bioactive Compounds. Organikerdagarna XXIII (Organic Chemistry Days XXIII), Göteborg, Sweden, June 12-15. x, x.
5.2.
2012
Bredihhina, Jevgenia; Andersons, Karlis; Villo, Piret; Vares, Lauri. (2012). Kinetic Resolution of Terminal Bis-Epoxides. Balticum Organicum Syntheticum (BOS), International Conference on Organic Synthesis, Tallinn, July 1-4. x, x.
5.2.
2012
Visnapuu, M.; Vares, L.; Borg-Karslon, A-K.; Liblikas, I. (2012). Stereoselective synthesis of lilac alcohols. International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012.: International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012. Vilnius, Lithuania: Vilnius University Publishing House, 188−188.
5.2.
2012
Andersone, A.; Vares, L.; Borg-Karlson, A-K.; Liblikas, I. (2012). Stereoselective synthesis of lilac alcohols and aldehyes. International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012.: International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012. Vilnius, Lithuania: Vilnius University Publishing House, 187−187.
5.1.
2010
Raal, A.; Remmel, I.; Vares, L.; Toom, L.; Jürgenson, S. (2010). Content of total polyphenols, tannins and flavonoids in Epilobium species growing in Estonia. Planta Medica, 76: 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural product Research, Berlin, 29.08.-02.09.10. Georg Thieme Verlag KG, 1224−1224. (12).
5.2.
2009
Villo, P.; Toom, L.; Liblikas, I.; Vares, L. (2009). Synthesis of N-Analogues of Acetogenins. In: (589).16-th European Symposium on Organic Chemistry; Prague, Czech Republic; 12th - 16th July, 2009. Prague.
1.1.
2008
Toom, L.; Villo, P.; Liblikas, I.; Vares, L. (2008). Synthesis of Amphiphilic Amino Alcohols. Synthetic Communications, 38 (23), 4295−4313.10.1080/00397910802326554.
1.1.
2008
Tamp, S.; Danilas, K.; Kreen, M.; Vares, L.; Kiirend, E.; Vija, S.; Pehk, T.; Parve, O.; Metsala, A. (2008). A Total Conformational Analysis of Diastereomeric Esters and Calculation of their Conformational shielding Models. Journal of Molecular Structure: THEOCHEM, 851, 84−91.
5.1.
2007
Toom, M.; Vares, L.; Kirsipuu, K.; Must, R.; Tenno, S.; Raal, A. (2007). Content of the carotenoids in the Pot marigold’s sorts cultivated in Estonia. European Journal of Pharmaceutical Sciences, 32(1) Suppl 1: 2nd BBBB Conference on Pharmaceutical Sciences; Tallinn-Tartu, Estonia; 13-15 September 2007. S25.
1.1.
2003
Vares, L.; Koulov, A.V.; Smith, B.D. (2003). Synthesis and Supramolecular Properties of Conformationally Restricted Phospholipids. Journal of Organic Chemistry, 68 (26), 10073−10078.
1.1.
2002
Koulov, Atanas; Vares, Lauri; Jain, Mahim; Smith, Bradley (2002). Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues. Biochimica et Biophysica Acta, 1564, 459−465.
1.1.
2002
Vares, L.; Kann, N.; Rein, T. (2002). A Versatile Stereocontrolled Approach to Chiral Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Sequential Asymmetric Horner-Wadsworth-Emmons and Ring Closure Reactions. Journal of Organic Chemistry, 67 (21), 7226−7237.
1.1.
2002
Vares, L.; Koulov, A.V.; Smith, B.D. (2002). Highly impermeable vesicles composed of conformationally restricted phosphatidylethanolamine. Chemical Communications, 14, 1482−1483.
5.1.
2002
Koulov, AV.; Vares, L.; Smith, BD. (2002). Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues. Biophysical Journal, 82 (1, 2), 2646.
1.1.
2000
Vares, L.; Rein, T (2000). A versatile stereocontrolled approach to chiral tetrahydrofuran and tetrahydropyran derivatives via sequential asymmetric Horner-Wadsworth-Emmons and palladium-catalyzed ring closure reactions. Organic Letters, 2 (17), 2611−2614.
5.1.
2000
Rein, T.; Vares, L.; Kawasaki, I.; Luhdorf, A.; Nielsen, K. (2000). Stereocontrolled synthesis of chiral oxa- and azacycles via asymmetric horner-wadsworth-emmons reactions. Abstracts of Papers of the American Chemical Society, 219 (2), 95−96.
5.2.
2000
Vares, L.; Rein, T. (2000). Towards the Total Syntheis of Mucocin. 17:e Organikedagarna; June 5-8, 2000; Stockholm, Sweden. Stockholm, A13.
1.1.
1999
Rein, T.; Vares, L.; Kawasaki, I.; Pedersen, TM.; Norrby, PO.; Brandt, P.; Tanner, D. (1999). Asymmetric Horner Wadsworth Emmons Reactions with Meso Dialdehydes: Scope, Mechanism, and Synthetic Applications. Phosphorus Sulfur and Silicon and the Related Elements, 146, 169−172.
5.2.
1999
Vares, L.; Rein, T. (1999). Synthetic Approaches to Chiral Tetrahydropyran Derivatives by Use of Asymmetric Horner-Wadsworth-Emmons Reaction. The 25th Estonian Chemistry Days; Tallinn, Estonia; November 22-25, 1999. Tallinn, 190.
1.1.
1998
Parve, Omar; Aidnik, Madis; Lille, Ülo; Martin, Ivar; Vallikivi, Imre; Vares, Lauri; Pehk, Tõnis (1998). The tetrahydropyranyl-protected mandelic acid: a novel versatile chiral derivatising agent. Tetrahedron-Asymmetry, 9 (5), 885−896.
1.1.
1998
Tullis, J. S.; Vares, L.; Kann, N.; Norrby, P.-O.; Rein, T. (1998). Reagent Control of Geometric Selectivity and Enantiotopic Group Preference in Asymmetric Horner-Wadsworth-Emmons Reactions with meso-Dialdehydes. Journal of Organic Chemistry, 63 (23), 8284−8294.
5.2.
1997
Vares, L.; Rein, T. (1997). Synthetic Approaches to Chiral Tetrahydropyran Derivatives by Use of Asymmetric Wittig-Type Reactions. 16:e Organikedagarna, June 9-12 1997, Uppsala, Sweden. 77.
5.2.
1996
Martin, I.; Parve, O.; Vares, L. (1996). Semiempirical transition state modeling of asymmetric alkylation reaction. In: Japan-Northern Baltic Symposium on Synthetic Chemistry, Helsinki (Finland), June 25-26, 1996 : abstracts (PL17).. Helsinki.
1.1.
1995
Martin, I.; Anvelt, J.; Vares, L.; Kühn, I.; Claesson, A. (1995). An Alternative Synthesis of the NMDA Antagonist CGS 19755 via Free Radical Carbamoylation of Ethyl Isonicotinate. Acta Chemica Scandinavica, 49 (3), 230−232.

Tööstusomand

21.01.2020

Lauri Vares

https://www.etis.ee/CV/Lauri_Vares/eng
27.03.1973
737 4808
lauri.vares@ut.ee

Career

Institutions and positions
19.02.2016–...   
University of Tartu, Faculty of Science and Technology, Institute of Technology, Senior Research Fellow in Organic Chemistry (1,00)
01.01.2014–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow in Organic Chemistry (1,00)
01.05.2013–31.12.2013   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow in Organic Chemistry (1,00)
01.10.2011–30.04.2013   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow in Organic Chemistry (1,00)
01.04.2011–30.09.2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow in Organic Chemistry (0,90)
01.01.2011–31.03.2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow in Organic Chemistry (0,20)
15.11.2010–31.12.2010   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow (0,20)
01.01.2008–14.11.2010   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow (1,00)
01.01.2006–31.12.2007   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow (1,00)
01.01.2005–31.12.2005   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Senior Research Fellow extraordinarius (1,00)
 
 
Education
1998–1998   
University of Notre Dame, USA
1996–1998   
Technical University of Denmark
1996–1996   
The Royal Institute of Technology (Sweden), licentiate degree
1991–1996   
Tallinn Technical University, graduated as chemistry engineer.
1980–1991   
Tallinna Reaalkool
 
 
R&D related managerial and administrative work
2010−...   
Scientific expert of the State Agency of Medicines
2007−2012   
Committee member of Institute of Technology
2006−2012   
Head of Chemistry Development Center at the Institute of Technology
 
 
Additional information
Jan. 2002 until dec. 2004 AstraZeneca, R&D Södertälje, Sweden. Senior Research Scientist;
Postdoc at the University of Notre Dame, USA, 2000-2001, supervior prof. Bradley D. Smith;

Qualifications

Academic degrees
Lauri Vares, Doctor's Degree, 2000, (sup) Tobias Rein, Stereoselective Synthesis of Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Asymmetric Horner-Wadsworth-Emmons and Ring Closure Reactions, University of Tartu.
 
 
Honours & awards
1996, Lauri Vares, My Diploma work “The Application of Tetrahydropyranyloxy group in Stereoselective Alkylation Reactions” won the first prize in Competition of Students Scientific work in Estonia in 1996.
 
 
Fields of research
ETIS CLASSIFICATION: 4. Natural Sciences and Engineering; 4.11. Chemistry and Chemical Technology; CERCS CLASSIFICATION: P390 Organic chemistry ; SPECIFICATION: Developing green chemistry solutions for sustainable society
ETIS CLASSIFICATION: 4. Natural Sciences and Engineering; 4.11. Chemistry and Chemical Technology; CERCS CLASSIFICATION: P390 Organic chemistry ; SPECIFICATION: Novel methods for asymmetric synthesis
 
 
Additional information
Development of technology for a new type of second generation biofuel. Energy technology grant 2011-2015
Novel biobased plastics for sustainable packaging industry, 2017-2019
Grant from Tartu University 2005-2007 "Synthesis of bioactive acetogenin analogs: physical and biological properties"
Estonian Science Foundation grant in 2000-2001 "New methods for the asymmetric synthesis of tetrahydropyrans and tetrahydrofurans and applications in the total synthesis of acetogenins.
Stipend from the Salén’i foundation (Sweden) in 1998
Stipend from the Nordic Council of Ministers (Denmark) in 1998
Stipend from the Swedish Institute in 1997
Stipend from the Axelanda Margret Johnson Foundation (Sweden) in 1996
Technology of Bioactive Compounds: improving the quality of research and teaching at the at Institute of Technology, University of Tartu. Grant from EU Social fund in 2007-2008

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Moreno, Adrian; Bensabeh, Nabil; Parve, Jaan; Ronda, Juan Carlos; Cadiz, Virginia; Galia, Marina; Vares, Lauri; Lligadas, Gerard; Percec, Virgil (2019). SET-LRP of Bio- and Petroleum-Sourced Methacrylates in Aqueous Alcoholic Mixtures. Biomacromolecules, 20, 1816−1827.10.1021/acs.biomac.9b00257.
1.1.
2018
Bredihhin, Aleksei; Salmer, Siim; Vares, Lauri (2018). A route for conversion of furfural to ethylcyclopentane. ACS Omega, 3 (8), 10211−10215.10.1021/acsomega.8b00588.
1.1.
2018
Matt, L.; Parve, J.; Parve, O.; Pehk, T.; Pham, T. H.; Liblikas, I.; Vares, L.; Jannasch, P. (2018).

Enzymatic Synthesis and Polymerization of Isosorbide-Based Monomethacrylates for High-Tg Plastics

. ACS Sustainable Chemistry & Engineering, 6 (12), 17382−17390.10.1021/acssuschemeng.8b05074.
5.2.
2018
Matt, L.; Parve, O.; Parve, J.; Pehk, T.; Vares, L.; Jannasch, P. (2018). Biocatalytic synthesis and polymerization of isosorbide-based monomethacrylates. 3rd Green & Sustainable Chemistry; Berlin, Germany; 13.-16. May 2018. Elsevier,.
3.1.
2017
Bredihhin, A.; Vares, L. (2017). Conversion of Biomass to Biofuels. In: Zerong Wang (_EditorsAbbr). Encyclopedia of Physical Organic Chemistry, 6 Volume Set (3653−3697). John Wiley & Sons Ltd.10.1002/9781118468586.
5.2.
2017
Matt, L.; Villo, P.; Toom, L.; Liblikas, I.; Pehk, T.; Vares, L. (2017). Hydroformylation of biomass-based olefinic derivatives of Isosorbide. Renewable plant resources: chemistry, technology, medicine; Saint Petersburg, Russia; 18-22. September 2017. Saint Petersburg: VVM Publishing, 60.
1.1.
2016
Bredihhin, Aleksei; Luiga, Sirvo; Vares, Lauri. (2016). Application of 5-ethoxymethylfurfural (EMF) for the production of cyclopentenones. Synthesis, 48 (23), 4181−4188.10.1055/s-0035-1562790.
1.1.
2016
Villo, P.; Matt, L.; Toom, L.; Liblikas, I.; Pehk, T.; Vares, L. (2016). Hydroformylation of Olefinic Derivatives of Isosorbide and Isomannide. Journal of Organic Chemistry, 81 (17), 7510−7517.10.1021/acs.joc.6b01179.
3.1.
2016
Parve, Jaan; Vares, Lauri; Reile, Indrek; Pehk, Tõnis; Villo, Ly; Parve, Omar (2016). Catalyzed Resolution and Simultaneous Selective Crystallization. In: Carlos A M Afonso, Nuno R Candeias, Dulce Pereira Simão, Alexandre F Trindade, Jaime A S Coelho, Bin Tan, Robert Franzén (Ed.). Comprehensive Organic Chemistry Experiments for the Laboratory Classroom (931−934). London: Royal Soc Chemistry.
1.1.
2015
Parve, J.; Reile, I.; Aid, T.; Kudrjašova, M.; Müürisepp, A.-M.; Vallikivi, I.; Villo, L.; Aav, R.; Pehk, T.; Vares, L.; Parve, O. (2015). Lipase-catalyzed stereoresolution of long-chain 1,2-alkanediols: a screening of preferable reaction conditions. Journal of Molecular Catalysis B: Enzymatic, 116, 60−69.10.1016/j.molcatb.2015.03.006.
3.1.
2015
Bredihhin, A.; Vares, L. (2015). Liquid Biofuels Usable in Motorized Transport. In: J.N. Govil (_EditorsAbbr). Energy Science and Technology, 12 Volume Set. Vol. 7: Bioenergy (310−331). Studium Press LLC.
1.1.
2014
Veidenberg, I.; Toom, L.; Villo, P.; Vares, L. (2014). An efficient and highly stereoselective approach to trans-2,5-disubstituted-tetrahydrofuran and trans-2,6-disubstituted-tetrahydropyran derivatives. Tetrahedron Letters, 55 (25), 3569−3571.10.1016/j.tetlet.2014.04.109.
1.1.
2014
Viil, I.; Bredihhin, A.; Mäeorg, U.; Vares, L. (2014). Preparation of potential biofuel 5-ethoxymethylfurfural and other 5-alkoxymethylfurfurals in the presence of oil shale ash. RSC Advances, 4 (11), 5689−5693.10.1039/C3RA46570E.
1.1.
2013
Parve, O.; Reile, I.; Parve, J.; Kasvandik, S.; Kudrjashova, M.; Tamp, S.; Metsala, A.; Villo, L.; Pehk, T.; Jarvet, J.; Vares, L. (2013). An NMR and MD Modeling Insight into Nucleation of 1,2-Alkanediols; Selective Crystallization of Lipase-Catalytically Resolved Enantiomers from the Reaction Mixtures. Journal of Organic Chemistry, 78 (24), 12795−12801.10.1021/jo402189e.
1.1.
2013
Villo, Piret; Toom, Lauri; Eriste, Elo; Vares, Lauri (2013). Synthesis of Linear Aza and Thio Analogues of Acetogenins and Evaluation of Their Cytotoxicity. European Journal of Organic Chemistry, 2013 (30), 6886−6899.10.1002/ejoc.201300767.
1.1.
2013
Karlström, Sofia; Nordvall, Gunnar; Sohn, Daniel; Hettman, Andreas; Turek, Dominika; Åhlin, Kristofer; Kers, Annika; Claesson, Martina; Slivo, Can; Lo-Alfredsson, Yvonne; Petersson, Carl; Bessidskaia, Galina; Svensson, Per H.; Rein, Tobias; Jerning, Eva; Malmberg, Åsa; Ahlgen, Charlotte; Ray, Colin; Vares, Lauri; Ivanov, Vladimir ... Johansson, Rolf (2013). Substituted 7‑Amino-5-thio-thiazolo[4,5‑d]pyrimidines as Potent and Selective Antagonists of the Fractalkine Receptor (CX3CR1). Journal of Medicinal Chemistry, 56 (8), 3177−3190.10.1021/jm3012273.
1.1.
2013
Doyle, E.; Parve, J.; Kudryashova, M.; Tamp, S.; Müürisepp, A.-M.; Villo, L.; Vares, L.; Pehk, T.; Parve, O. (2013). Synthesis and Quantitative Analysis of Diastereomeric Linked Ester Conjugates with Remote Stereocenters Using High Field NMR and Chiral HPLC. Chirality, 25 (11), 793−798.10.1002/chir.22217.
1.1.
2013
Bredihhin, A.; Mäeorg, U.; Vares, L. (2013). Evaluation of carbohydrates and lignocellulosic biomass from different wood species as raw material for the synthesis of 5-bromomethyfurfural. Carbohydrate Research, 375, 63−67.10.1016/j.carres.2013.04.002.
1.1.
2013
Bredihhina, J.; Villo, P.; Andersons, K.; Toom, L.; Vares, L. (2013). Hydrolytic and Aminolytic Kinetic Resolution of Terminal Bis-Epoxides. Journal of Organic Chemistry, 78 (6), 2379−2385.10.1021/jo3024335.
5.2.
2013
Villo, Piret; Toom, Lauri; Vares, Lauri (2013). Synthesis of Aza- and Thio-Analogues of Acetogenins. Abstracts: Komppa Symposium, Aalto University, Espoo, Finland, 24.-26.06.2013.
1.1.
2012
Remmel, I.; Vares, Lauri; Toom, Lauri; Matto, Vallo; Raal, Ain (2012). Phenolic compounds in five Epilobium species collected from Estonia. Natural Product Communications, 7 (10), 1323−1324.
5.2.
2012
Veskilt, E.; Tamp, S.; Parve, J.; Vares, L.; Pehk, T.; Villo, L.; Parve, O. (2012). O-Alkylation of hydroxycarboxylic acids with (-)-menthyl bromoacetate affords bridged diastereomeric esters. Balticum Organicum Syntheticum, Tallinn 2012.
5.2.
2012
Villo, Piret; Bredihhina, Jevgenia; Andersons, Karlis; Vares, Lauri. (2012). Hydrolytic Kinetic Resolution of Terminal Diepoxides in the Synthesis of Bioactive Compounds. Organikerdagarna XXIII (Organic Chemistry Days XXIII), Göteborg, Sweden, June 12-15. x, x.
5.2.
2012
Bredihhina, Jevgenia; Andersons, Karlis; Villo, Piret; Vares, Lauri. (2012). Kinetic Resolution of Terminal Bis-Epoxides. Balticum Organicum Syntheticum (BOS), International Conference on Organic Synthesis, Tallinn, July 1-4. x, x.
5.2.
2012
Visnapuu, M.; Vares, L.; Borg-Karslon, A-K.; Liblikas, I. (2012). Stereoselective synthesis of lilac alcohols. International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012.: International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012. Vilnius, Lithuania: Vilnius University Publishing House, 188−188.
5.2.
2012
Andersone, A.; Vares, L.; Borg-Karlson, A-K.; Liblikas, I. (2012). Stereoselective synthesis of lilac alcohols and aldehyes. International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012.: International Society of Chemical Ecology, 28th Annual Meeting, Vilnius, Lithuania, July 22-26, 2012. Vilnius, Lithuania: Vilnius University Publishing House, 187−187.
5.1.
2010
Raal, A.; Remmel, I.; Vares, L.; Toom, L.; Jürgenson, S. (2010). Content of total polyphenols, tannins and flavonoids in Epilobium species growing in Estonia. Planta Medica, 76: 58th International Congress and Annual Meeting of the Society for Medicinal Plant and Natural product Research, Berlin, 29.08.-02.09.10. Georg Thieme Verlag KG, 1224−1224. (12).
5.2.
2009
Villo, P.; Toom, L.; Liblikas, I.; Vares, L. (2009). Synthesis of N-Analogues of Acetogenins. In: (589).16-th European Symposium on Organic Chemistry; Prague, Czech Republic; 12th - 16th July, 2009. Prague.
1.1.
2008
Toom, L.; Villo, P.; Liblikas, I.; Vares, L. (2008). Synthesis of Amphiphilic Amino Alcohols. Synthetic Communications, 38 (23), 4295−4313.10.1080/00397910802326554.
1.1.
2008
Tamp, S.; Danilas, K.; Kreen, M.; Vares, L.; Kiirend, E.; Vija, S.; Pehk, T.; Parve, O.; Metsala, A. (2008). A Total Conformational Analysis of Diastereomeric Esters and Calculation of their Conformational shielding Models. Journal of Molecular Structure: THEOCHEM, 851, 84−91.
5.1.
2007
Toom, M.; Vares, L.; Kirsipuu, K.; Must, R.; Tenno, S.; Raal, A. (2007). Content of the carotenoids in the Pot marigold’s sorts cultivated in Estonia. European Journal of Pharmaceutical Sciences, 32(1) Suppl 1: 2nd BBBB Conference on Pharmaceutical Sciences; Tallinn-Tartu, Estonia; 13-15 September 2007. S25.
1.1.
2003
Vares, L.; Koulov, A.V.; Smith, B.D. (2003). Synthesis and Supramolecular Properties of Conformationally Restricted Phospholipids. Journal of Organic Chemistry, 68 (26), 10073−10078.
1.1.
2002
Koulov, Atanas; Vares, Lauri; Jain, Mahim; Smith, Bradley (2002). Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues. Biochimica et Biophysica Acta, 1564, 459−465.
1.1.
2002
Vares, L.; Kann, N.; Rein, T. (2002). A Versatile Stereocontrolled Approach to Chiral Tetrahydrofuran and Tetrahydropyran Derivatives by Use of Sequential Asymmetric Horner-Wadsworth-Emmons and Ring Closure Reactions. Journal of Organic Chemistry, 67 (21), 7226−7237.
1.1.
2002
Vares, L.; Koulov, A.V.; Smith, B.D. (2002). Highly impermeable vesicles composed of conformationally restricted phosphatidylethanolamine. Chemical Communications, 14, 1482−1483.
5.1.
2002
Koulov, AV.; Vares, L.; Smith, BD. (2002). Cationic triple-chain amphiphiles facilitate vesicle fusion compared to double-chain or single-chain analogues. Biophysical Journal, 82 (1, 2), 2646.
1.1.
2000
Vares, L.; Rein, T (2000). A versatile stereocontrolled approach to chiral tetrahydrofuran and tetrahydropyran derivatives via sequential asymmetric Horner-Wadsworth-Emmons and palladium-catalyzed ring closure reactions. Organic Letters, 2 (17), 2611−2614.
5.1.
2000
Rein, T.; Vares, L.; Kawasaki, I.; Luhdorf, A.; Nielsen, K. (2000). Stereocontrolled synthesis of chiral oxa- and azacycles via asymmetric horner-wadsworth-emmons reactions. Abstracts of Papers of the American Chemical Society, 219 (2), 95−96.
5.2.
2000
Vares, L.; Rein, T. (2000). Towards the Total Syntheis of Mucocin. 17:e Organikedagarna; June 5-8, 2000; Stockholm, Sweden. Stockholm, A13.
1.1.
1999
Rein, T.; Vares, L.; Kawasaki, I.; Pedersen, TM.; Norrby, PO.; Brandt, P.; Tanner, D. (1999). Asymmetric Horner Wadsworth Emmons Reactions with Meso Dialdehydes: Scope, Mechanism, and Synthetic Applications. Phosphorus Sulfur and Silicon and the Related Elements, 146, 169−172.
5.2.
1999
Vares, L.; Rein, T. (1999). Synthetic Approaches to Chiral Tetrahydropyran Derivatives by Use of Asymmetric Horner-Wadsworth-Emmons Reaction. The 25th Estonian Chemistry Days; Tallinn, Estonia; November 22-25, 1999. Tallinn, 190.
1.1.
1998
Parve, Omar; Aidnik, Madis; Lille, Ülo; Martin, Ivar; Vallikivi, Imre; Vares, Lauri; Pehk, Tõnis (1998). The tetrahydropyranyl-protected mandelic acid: a novel versatile chiral derivatising agent. Tetrahedron-Asymmetry, 9 (5), 885−896.
1.1.
1998
Tullis, J. S.; Vares, L.; Kann, N.; Norrby, P.-O.; Rein, T. (1998). Reagent Control of Geometric Selectivity and Enantiotopic Group Preference in Asymmetric Horner-Wadsworth-Emmons Reactions with meso-Dialdehydes. Journal of Organic Chemistry, 63 (23), 8284−8294.
5.2.
1997
Vares, L.; Rein, T. (1997). Synthetic Approaches to Chiral Tetrahydropyran Derivatives by Use of Asymmetric Wittig-Type Reactions. 16:e Organikedagarna, June 9-12 1997, Uppsala, Sweden. 77.
5.2.
1996
Martin, I.; Parve, O.; Vares, L. (1996). Semiempirical transition state modeling of asymmetric alkylation reaction. In: Japan-Northern Baltic Symposium on Synthetic Chemistry, Helsinki (Finland), June 25-26, 1996 : abstracts (PL17).. Helsinki.
1.1.
1995
Martin, I.; Anvelt, J.; Vares, L.; Kühn, I.; Claesson, A. (1995). An Alternative Synthesis of the NMDA Antagonist CGS 19755 via Free Radical Carbamoylation of Ethyl Isonicotinate. Acta Chemica Scandinavica, 49 (3), 230−232.

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21.01.2020

Otsi projekti

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF78081,3-Dipolaarsed tsükloliitumis-reaktsioonid kui uus meetod vitsinaalsete aminoalkoholide sünteesiks 01.01.200931.12.2012Peter SomfaiTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond73 473,04 EUR
SFSF0182564s03Antibiootikumide toimemehhanismid01.01.200331.12.2007Tanel TensonTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut317 960,45 EUR
SFSF0180073s08Atsetogeniinide analoogide süntees ja bioloogilised omadused01.01.200831.12.2013Ilme LiblikasTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut559 780,51 EUR
ETFETF6520Atsetogeniinide analoogide süntees ja nende füüsikalis-bioloogiliste omaduste uurimine01.01.200531.12.2008Lauri VaresTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond30 618,80 EUR
MUUNP1TI07043Bioaktiivsete ainete Tehnoloogia Tehnoloogiainstituudis: õppe- ja teadustöö kvaliteedi tõstmine TÜ Tehnoloogiainstituudis01.02.200730.06.2008Lauri VaresTartu Ülikool83 159,02 EUR
2.1.1.LLTTI18118Biolaguneva pakendi valmistamine02.01.201810.02.2019Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut28 500,00 EUR
ETFETF7009Ensüüm-katalüütiliste reaktsioonide kasutamine bioaktiivsete ainete ja nende vaheühendite sünteesil ning modifitseerimisel01.01.200731.12.2010Imre VallikiviTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond42 768,38 EUR
2.2.1.VLTTI19672 Isosorbiid-metakrülaatide süntees01.05.201931.08.2020Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut0,00 EUR
MUUILOTI08203KKeemiatööstuse lähteainete saamine süsivesikutest01.10.200831.01.2009Lauri VaresTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut16 021,26 EUR
MTTMTT2Keemiline ökoloogia01.11.200931.12.2014Anna Karin Maria Borg KarlssonTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut479 337,36 EUR
1.1.5.3.4.LLTTI17511Klaasplasti pinnauuringud18.09.201715.12.2017Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut5 000,00 EUR
MUULLTTI16016Lehtpuidu konverteerimine kõrge väärtusega kemikaalideks01.01.201631.12.2018Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut150 473,00 EUR
1.1.7.2.1SLTTI16038 (11064)Lehtpuidu konverteerimine kõrge väärtusega kemikaalideks01.01.201631.12.2018Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut162 187,00 EUR
RITA1AlamprojektLLTTI18111 (RITA1/01-18-08)Lisandväärtuse tõstmine ja toorme tõhusam kasutamine Eesti biomajanduses ja selle sektorites01.03.201828.02.2021Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut102 351,15 EUR
1.1.5.2.1.30.SLOTI10205TTehnoloogia väljatöötamine uut tüüpi teise põlvkonna biokütuse saamiseks01.01.201131.12.2015Lauri VaresTartu Ülikool602 293,98 EUR
MUULLOTI08183Tuumamagnetresonants spektomeetri kasutamine01.10.200831.12.2012Lauri VaresTartu Ülikool13 421,45 EUR
1.2.2.1.14.1.MLTTI17449IUudsed bio-toormel põhinevad pakendid01.09.201731.08.2018Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut16 150,00 EUR
EMPEMP426Uudsed kõrgtehnoloogilised polümeerid lignotselluloosilisest toormest01.09.201930.08.2022Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut0,00 EUR
1.2.2.1.14.9.MLTTI19381I Uudsed ligniinil baseeruvad plastikud01.06.201930.04.2022Lauri VaresTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut191 814,80 EUR (kogurahastus 458 929,76 EUR)
MOBTTMOBTT21Uudsed plastikud ja kemikaalid lignotselluloosilisest toormest01.07.201730.06.2022Patric JannaschTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut737 651,98 EUR