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Ljudmilla Tšekulajeva

https://www.etis.ee/CV/Ljudmilla_Tšekulajeva/est
1.10.1962
6204378
53-43-53-91
mila@stv.ee

Teenistuskäik

Töökohad ja ametid
2008–31.12.2009   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Genoomika ja proteoomika õppetool, Teadur (1,00)
1999–2007   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool, Teadur (1,00)
01.01.1994–31.12.1999   
ETA Keemia Instituut, insener
01.01.1986–31.12.1989   
Moskva Onkoloogia Keskus, vaneminsener
01.01.1980–31.12.1985   
Moskva Onkoloogia Keskus, laborant
 
 
Haridustee
2002–2006   
Tallinna Tehnikaülikool, keemia, Filosoofia doktor
2000–2001   
Tallinna Tehnikaülikool, keemia- ja materjaliteadus, Loodusteaduste magister
1982–1989   
Moskva Mendelejevi nimeline keemia-tehnoloogia Instituut, biotehnoloogiainsener
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
Eesti Keemia Seltsi liige

Kvalifikatsioon

Teaduskraadid
Ljudmilla Tšekulajeva, doktorikraad, 2006, (juh) Nigulas Samel; Igor Ševtšuk, Photosensitized inactivation of tumor cells by porphyrins and chlorins (Kasvajarakkude fotosensibiliseeritud hävimine porfüriinide ja kloriinede toimel), Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut.
Ljudmilla Tšekulajeva, magistrikraad, 2001, (juh) Igor Ševtšuk, Kasvajate ravis kasutatavate mõningate porfüriinide fotokeemilised transformatsioonid, Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.1. Biomeditsiin

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2008
Chekulayeva, Lyudmila; Chekulayev, Vladimir; Shevchuk, Igor (2008). Active oxygen intermediates in the degradation of hematoporphyrin derivative in tumor cells subjected to photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology, 93, 94−107.
1.1.
2007
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V.; Oginskaya, E. (2007). Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivative. Neoplasma, 54 (3), 229−234.
1.2.
2007
Chekulayeva, L., Shevchuk, I.; Chekulayev, V.; Oginskaya, E. (2007). On the mechanism of reactive oxygen species generation in tumour cells subjected to the phototoxic action of haematoporphyrin derivative: effect of heating. Proceedings of the Estonian Academy of Sciences. Chemistry, 56 (1), 14−37.
5.2.
2007
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V.; Palumaa, P. (2007). Porphyrins and bilirubin can suppress the aggregation of Alzheimer beta-amyloid peptide. 30th Estonian Chemistry Days Abstracts of Scientific Conference: 30th Estonian Chemistry Days, Tartu 2007. Taru, Estonia: Tartu University, 165−166.
1.1.
2006
Chekulayeva, LV.; Shevchuk, IN.; Chekulayev, VA.; Ilmarinen, K. (2006). Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells. Journal of Environmental Pathology Toxicology and Oncology, 25, 51−77.
2.3.
2006
Chekulayeva, L. (2006). Photosensitized Inactivation of Tumor Cells by Porphyrins and Chlorins. (Doktoritöö, Tallinna Tehnikaülikool). Tallinn: Tallinna Tehnikaülikooli Kirjastus.
1.2.
2005
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V. (2005). On the mechanism of the phototoxic action of haematoporphyrin derivative towards tumour cells. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 54 (2), 83−119.
1.1.
2004
Chekulayeva, LV.; Shevchuk, IN.; Chekulayev, VA (2004). Influence of temperature on the efficiency of photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology, 26 (2), 125−139.
1.2.
2003
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V. (2003). Photodynamic therapy of tumours with chlorin-e6 is pH dependent. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 52 (1), 40−54.
1.2.
2003
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L. (2003). On the mechanism of cellular death under photoexcitation of haematoporphyrin derivative. Proceedings of the Estonian Academy of Sciences. Ecology, 51 (1), 55−72.
1.1.
2002
Shevchuk, IN.; Chekulayeva, LV.; Chekulayev, VA. (2002). Influence of pH and glucose administration on the phototoxicity of chlorin-e6 towards Ehrlich carcinoma cells. Experimental Oncology (Kiev), 24 (2), 135−141.
1.1.
2002
Shevchuk, IN.; Chekulayev, VA.; Chekulayeva, LV (2002). The role of lipid peroxidation and protein degradation in the photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology, 24 (3), 216−224.
1.2.
2002
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Jäälaid, R. (2002). Kinetic studies on the mechanism of hematoporphyrin derivative photobleaching. Proceedings of the Estonian Academy of Sciences. Chemistry, 51 (1), 49−70.
1.2.
2000
Chekulayeva, L.; Shevchuk, I.; Jäälaid, R.; Chekulayev, V. (2000). L-Buthionine-[S,R]-sulfoximine may enhance the rate of haematoporphyrin derivative photosensitized inactivation of tumour cells without lowering of the intracellular content of glutathione. Proceedings of the Estonian Academy of Sciences. Chemistry, 49, 109−120.
1.2.
2000
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Jäälaid, R. (2000). Influence of extracellular magnesium on the antitumour efficiency of photodynamic therapy. Proceedings of the Estonian Academy of Sciences. Chemistry, 49 (4), 216−233.
1.1.
1998
Shevchuk, I.; Chekulayev, V.; Chekulayeva, L (1998). Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole. Journal of Photochemistry and Photobiology B: Biology, 45, 136−143.
1.2.
1998
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L. (1998). Effects of light exposure on the uptake and destruction of hematoporphyrin derivative in Ehrlich carcinoma cell suspension. Proceedings of the Estonian Academy of Sciences. Chemistry, 47, 73−91.
1.1.
1997
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Kahru, A. (1997). Study of the photochemical and phototoxic properties of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazol-3-carboxylic acid]. Journal of Photochemistry and Photobiology B: Biology, 41, 11−21.
1.2.
1997
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L. (1997). Photooxidation of hematoporphyrin derivative - bovine serum albumin complex. Proceedings of the Estonian Academy of Sciences. Chemistry, 46, 168−185.
5.2.
1997
Shevchuk, I.; Chekulayev, V.; Chekulayeva, L.; Kahru, A. (1997). Phototoxicity of lonidamine, and antitumour agent, towards mammary cells. Human and Experimental Toxicology, 16 (10), 623.
1.2.
1996
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Kahru, A. (1996). Increasing the efficiency of photosensitized damage of Erlich ascites carcinoma cells using haematoporphyrin derivative or chlorin-e6 in combination with lonidamine. Proceedings of the Estonian Academy. Aci. Biology, 45, 102−127.
5.01.2021

Ljudmilla Tšekulajeva

https://www.etis.ee/CV/Ljudmilla_Tšekulajeva/eng
1.10.1962
6204378
53-43-53-91
mila@stv.ee

Career

Institutions and positions
2008–31.12.2009   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Genomics and Proteomics, Researcher (1,00)
1999–2007   
Tallinn University of Technology , Faculty of Science, Department of Chemistry, Chair of Bioorganic Chemistry, Researcher (1,00)
01.01.1994–31.12.1999   
Institute of Chemistry of the Estonian Academy of Sciences, Department of Bioorganic Chemistry, research engineer
01.01.1986–31.12.1989   
All-Union Oncological Research Centre, Moscow, senior engineer
01.01.1980–31.12.1985   
Laboratory assistant of the Division of Clinical Immunology, All-Union Oncological Research Centre, Moscow
 
 
Education
2002–2006   
Tallinn University of Technology, chemistry, PhD
2000–2001   
Tallinn Technical University, Master of Science
1982–1989   
Moscow Mendeleyev Chemical Technology Institute - Diploma in Biotechnology

Qualifications

Academic degrees
Ljudmilla Tšekulajeva, Doctor's Degree, 2006, (sup) Nigulas Samel; Igor Ševtšuk, Photosensitized inactivation of tumor cells by porphyrins and chlorins, Tallinn University of Technology Faculty of Science, Department of Chemistry.
Ljudmilla Tšekulajeva, Master's Degree, 2001, (sup) Igor Ševtšuk, Kasvajate ravis kasutatavate mõningate porfüriinide fotokeemilised transformatsioonid, Tallinn University of Technology Faculty of Science, Department of Chemistry.
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.1. Biomedicine

Publications

Category
Year
Publication
 
1.1.
2008
Chekulayeva, Lyudmila; Chekulayev, Vladimir; Shevchuk, Igor (2008). Active oxygen intermediates in the degradation of hematoporphyrin derivative in tumor cells subjected to photodynamic therapy. Journal of Photochemistry and Photobiology B: Biology, 93, 94−107.
1.1.
2007
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V.; Oginskaya, E. (2007). Influence of heating on the activity of xanthine oxidase in tumor cells subjected to the phototoxic action of hematoporphyrin derivative. Neoplasma, 54 (3), 229−234.
1.2.
2007
Chekulayeva, L., Shevchuk, I.; Chekulayev, V.; Oginskaya, E. (2007). On the mechanism of reactive oxygen species generation in tumour cells subjected to the phototoxic action of haematoporphyrin derivative: effect of heating. Proceedings of the Estonian Academy of Sciences. Chemistry, 56 (1), 14−37.
5.2.
2007
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V.; Palumaa, P. (2007). Porphyrins and bilirubin can suppress the aggregation of Alzheimer beta-amyloid peptide. 30th Estonian Chemistry Days Abstracts of Scientific Conference: 30th Estonian Chemistry Days, Tartu 2007. Taru, Estonia: Tartu University, 165−166.
1.1.
2006
Chekulayeva, LV.; Shevchuk, IN.; Chekulayev, VA.; Ilmarinen, K. (2006). Hydrogen peroxide, superoxide, and hydroxyl radicals are involved in the phototoxic action of hematoporphyrin derivative against tumor cells. Journal of Environmental Pathology Toxicology and Oncology, 25, 51−77.
2.3.
2006
Chekulayeva, L. (2006). Photosensitized Inactivation of Tumor Cells by Porphyrins and Chlorins. (Doktoritöö, Tallinna Tehnikaülikool). Tallinn: Tallinna Tehnikaülikooli Kirjastus.
1.2.
2005
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V. (2005). On the mechanism of the phototoxic action of haematoporphyrin derivative towards tumour cells. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 54 (2), 83−119.
1.1.
2004
Chekulayeva, LV.; Shevchuk, IN.; Chekulayev, VA (2004). Influence of temperature on the efficiency of photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology, 26 (2), 125−139.
1.2.
2003
Chekulayeva, L.; Shevchuk, I.; Chekulayev, V. (2003). Photodynamic therapy of tumours with chlorin-e6 is pH dependent. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 52 (1), 40−54.
1.2.
2003
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L. (2003). On the mechanism of cellular death under photoexcitation of haematoporphyrin derivative. Proceedings of the Estonian Academy of Sciences. Ecology, 51 (1), 55−72.
1.1.
2002
Shevchuk, IN.; Chekulayeva, LV.; Chekulayev, VA. (2002). Influence of pH and glucose administration on the phototoxicity of chlorin-e6 towards Ehrlich carcinoma cells. Experimental Oncology (Kiev), 24 (2), 135−141.
1.1.
2002
Shevchuk, IN.; Chekulayev, VA.; Chekulayeva, LV (2002). The role of lipid peroxidation and protein degradation in the photodestruction of Ehrlich ascites carcinoma cells sensitized by hematoporphyrin derivative. Experimental Oncology, 24 (3), 216−224.
1.2.
2002
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Jäälaid, R. (2002). Kinetic studies on the mechanism of hematoporphyrin derivative photobleaching. Proceedings of the Estonian Academy of Sciences. Chemistry, 51 (1), 49−70.
1.2.
2000
Chekulayeva, L.; Shevchuk, I.; Jäälaid, R.; Chekulayev, V. (2000). L-Buthionine-[S,R]-sulfoximine may enhance the rate of haematoporphyrin derivative photosensitized inactivation of tumour cells without lowering of the intracellular content of glutathione. Proceedings of the Estonian Academy of Sciences. Chemistry, 49, 109−120.
1.2.
2000
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Jäälaid, R. (2000). Influence of extracellular magnesium on the antitumour efficiency of photodynamic therapy. Proceedings of the Estonian Academy of Sciences. Chemistry, 49 (4), 216−233.
1.1.
1998
Shevchuk, I.; Chekulayev, V.; Chekulayeva, L (1998). Enhancement of the efficiency of photodynamic therapy of tumours by t-butyl-4-hydroxyanisole. Journal of Photochemistry and Photobiology B: Biology, 45, 136−143.
1.2.
1998
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L. (1998). Effects of light exposure on the uptake and destruction of hematoporphyrin derivative in Ehrlich carcinoma cell suspension. Proceedings of the Estonian Academy of Sciences. Chemistry, 47, 73−91.
1.1.
1997
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Kahru, A. (1997). Study of the photochemical and phototoxic properties of lonidamine [1-(2,4-dichlorobenzyl)-1H-indazol-3-carboxylic acid]. Journal of Photochemistry and Photobiology B: Biology, 41, 11−21.
1.2.
1997
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L. (1997). Photooxidation of hematoporphyrin derivative - bovine serum albumin complex. Proceedings of the Estonian Academy of Sciences. Chemistry, 46, 168−185.
5.2.
1997
Shevchuk, I.; Chekulayev, V.; Chekulayeva, L.; Kahru, A. (1997). Phototoxicity of lonidamine, and antitumour agent, towards mammary cells. Human and Experimental Toxicology, 16 (10), 623.
1.2.
1996
Chekulayev, V.; Shevchuk, I.; Chekulayeva, L.; Kahru, A. (1996). Increasing the efficiency of photosensitized damage of Erlich ascites carcinoma cells using haematoporphyrin derivative or chlorin-e6 in combination with lonidamine. Proceedings of the Estonian Academy. Aci. Biology, 45, 102−127.
5.01.2021

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
MUUB602Kasvajarakkude fotosensibiliseeritud hävimine tetrapürroolsete ühendite toimel01.01.200631.12.2007Igor ŠevtšukTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Bioorgaanilise keemia õppetool73 370,57 EUR
ETFETF5906Mõningate fotoaktiivsete tetrapürroolide ja dendrimeeride kompleksite süntees ja iseloomustamine01.01.200431.12.2007Igor ŠevtšukTallinna Tehnikaülikool, Matemaatika-loodusteaduskond23 352,57 EUR
SFSF0140055s08Struktuurne ja meditsiiniline metalloproteoomika01.01.200831.12.2013Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond937 814,19 EUR
SFSF0142501s03Struktuurne ja meditsiiniline proteoomika01.01.200331.12.2007Peep PalumaaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond206 498,53 EUR
SFSF0351763s01Tetrapürroolsete ühendite fototoksilise toime uurimine imetajate rakkudel01.01.200131.12.2005Igor ŠevtšukTallinna Tehnikaülikool, Matemaatika-loodusteaduskond101 044,30 EUR