Maris Alver

https://www.etis.ee/CV/Maris_Alver/est
28.07.1986
737 4002
5138474
maris.alver@ut.ee

Teenistuskäik

Töökohad ja ametid
01.10.2015–...   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, spetsialist (1,00)
01.01.2018–09.07.2019   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, spetsialist (1,00)
01.08.2012–30.09.2015   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, spetsialist (0,50)
2009–2009   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut, laborant (1,00)
2008–2009   
Eesti Biokeskus, Vanemlaborant (0,10)
 
 
Haridustee
2012–...   
Doktoriõpe molekulaarse biomeditsiini eralal, Tartu Ülikool
2010–2012   
Magistriõpe biomeditsiini erialal, cum laude, Tartu Ülikool, cum laude
2005–2009   
Bakalaureuseõpe geenitehnoloogia erialal, Tartu Ülikool
1994–2005   
Tallinna Inglise Kolledž
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2015−...   
Eesti Inimesegeneetika Ühingu liige

Kvalifikatsioon

Teaduskraadid
Maris Alver, doktorikraad, 2019, (juh) Andres Metspalu; Tõnu Esko, Value of genomics for atherosclerotic cardiovascular disease risk prediction (Geeniinfo väärtus südame-veresoonkonnahaiguste riski hindamisel), Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut.
Maris Alver, magistrikraad, 2012, (juh) Riin Tamm; Andres Metspalu, Pikaealisuse ja vananemise geneetiliste markerite otsingul, Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, Biotehnoloogia õppetool.
 
 
Teadustöö põhisuunad
VALDKOND: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS ERIALA: T490 Biotehnoloogia
VALDKOND: 1. Bio- ja keskkonnateadused; 1.3. Geneetika; CERCS ERIALA: B220 Geneetika, tsütogeneetika
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin; CERCS ERIALA: B726 Kliiniline bioloogia
VALDKOND: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS ERIALA: B110 Bioinformaatika, meditsiiniinformaatika, biomatemaatika, biomeetrika

Jooksvad projektid

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Saar, Aet; Läll, Kristi; Alver, Maris; Marandi, Toomas; Ainla, Tiia; Eha, Jaan; Metspalu, Andres; Fischer, Krista (2019). Estimating the performance of three cardiovascular disease risk scores: the Estonian Biobank cohort study. Journal of Epidemiology and Community Health.10.1136/jech-2017-209965 [ilmumas].
1.1.
2019
de Vries, Paul S; Brown, Michael R; Bentley, Amy R; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C (2019). Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology.10.1093/aje/kwz005 [ilmumas].
1.1.
2019
Kilpelainen, Tuomas O.; Bentley, Amy R.; Noordam, Raymond; Sung, Yun Ju; Schwander, Karen; Winkler, Thomas W.; Jakupovic, Hermina; Chasman, Daniel I.; Manning, Alisa; Ntalla, Ioanna; Aschard, Hugues; Brown, Michael R.; de las Fuentes, Lisa; Franceschini, Nora; Guo, Xiuqing; Vojinovic, Dina; Aslibekyan, Stella; Feitosa, Mary F.; Kho, Minjung; Musani, Solomon K. ... Loos, Ruth J. F. (2019). Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, 10, ARTN 376.10.1038/s41467-018-08008-w.
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in medicine, 1−8.10.1038/s41436-018-0311-2 [ilmumas].
1.1.
2019
Adlam, David; Olson, Timothy M.; Combaret, Nicolas; Kovacic, Jason C.; Iismaa, Siiri E.; Al-Hussaini, Abtehale; O'Byrne, Megan M.; Bouajila, Sara; Georges, Adrien; Mishra, Ketan; Braund, Peter S.; d'Escamard, Valentina; Huang, Siying; Margaritis, Marios; Nelson, Christopher P.; de Andrade, Mariza; Kadian-Dodov, Daniella; Welch, Catherine A.; Mazurkiewicz, Stephani; Jeunemaitre, Xavier ... Bouatia-Naji, Nabila (2019). Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. Journal of the American College of Cardiology, 73 (1), 58−66.10.1016/j.jacc.2018.09.085.
1.1.
2019
Patel, Riyaz S.; Tragante, Vinicius; Schmidt, Amand F.; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behloui, Hassan; Boeckx, Bram; Braund, Peter S.; Breitling, Lutz P. ... Asselbergs, Folkert W. (2019). Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium. Circulation. Genomic and Precision Medicine, 12 (4), ARTN e002470.10.1161/CIRCGEN.119.002470.
1.1.
2019
Patel, Riyaz S.; Schmidt, Amand F.; Tragante, Vinicius; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Dube, Marie-Pierre; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behlouli, Hassan; Boeckx, Bram; Braund, Peter S. ... Asselbergs, Folkert W. (2019). Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data. Circulation. Genomic and Precision Medicine, 12 (4), 161−172.10.1161/CIRCGEN.119.002471.
1.1.
2018
Natarajan, Pradeep; Peloso, Gina M; Zekavat, Seyedeh Maryam; Montasser, May; Ganna, Andrea; Chaffin, Mark; Khera, Amit V; Zhou, Wei; Bloom, Jonathan M; Engreitz, Jesse M; Ernst, Jason; O'Connell, Jeffrey R; Ruotsalainen, Sanni E; Alver, Maris; Manichaikul, Ani; Johnson, W Craig; Perry, James A; Poterba, Timothy; Seed, Cotton; Surakka, Ida L ... , (2018). Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nature Communications, 9 (1), 3391−3391.10.1038/s41467-018-05747-8.
1.1.
2018
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
1.1.
2018
Zekavat, Seyedeh M; Ruotsalainen, Sanni; Handsaker, Robert E; Alver, Maris; Bloom, Jonathan; Poterba, Timothy; Seed, Cotton; Ernst, Jason; Chaffin, Mark; Engreitz, Jesse; Peloso, Gina M; Manichaikul, Ani; Yang, Chaojie; Ryan, Kathleen A; Fu, Mao; Johnson, W Craig; Tsai, Michael; Budoff, Matthew; Vasan, Ramachandran S; Cupples, L Adrienne ... , (2018). Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nature Communications, 9 (1), 2606−2606.10.1038/s41467-018-04668-w.
1.1.
2018
Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
1.1.
2017
Webb, Thomas R.; Erdmann, Jeanette; Stirrups, Kathleen E.; Stitziel, Nathan O.; Masca, Nicholas G. D.; Jansen, Henning; Kanoni, Stavroula; Nelson, Christopher P.; Ferrario, Paola G.; Koenig, Inke R.; Eicher, John D.; Johnson, Andrew D.; Hamby, Stephen E.; Betsholtz, Christer; Ruusalepp, Arno; Franzen, Oscar; Schadt, Eric E.; Bjoerkegren, Johan L. M.; Weeke, Peter E.; Auer, Paul L. ... Kathiresan, Sekar (2017). Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology, 7, 823−836.10.1016/j.jacc.2016.11.056.
1.1.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 3, 403−415.10.1038/ng.3768.
1.1.
2016
Stitziel, Nathan O; Stirrups, Kathleen E; Masca, Nicholas G D; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E; Webb, Thomas R; Auer, Paul L; Schick, Ursula M; Lu, Yingchang; Zhang, He; Dube, Marie-Pierre; Goel, Anuj; Farrall, Martin; Peloso, Gina M; Won, Hong-Hee; Do, Ron; van Iperen, Erik ... Schunkert, Heribert. (2016). Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. New England Journal of Medicine, 374 (12), 1134−1144.10.1056/NEJMoa1507652.
1.1.
2016
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium. (2016). Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science, 351 (6278), 1166−1171.10.1126/science.aad3517.
1.1.
2016
Elosua, Roberto; Lluís-Ganella, Carla; Subirana, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin; Sayols-Baixeras, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí, Mariano; Siscovick, David; Melander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat, Jaume (2016). Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater than the Parts? A Genetic Approach. Circulation. Cardiovascular genetics, 9 (3), 279−286.
1.1.
2016
Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC, Kanoni S, Kleber ME, Lau KW, Lu Y, Lyytikäinen LP, Nelson CP, Nikpay M, Qu L, Salfati E, Scholz M, Tukiainen T, Willenborg C, Won HH, Zeng L, Zhang W, Anand SS, Beutner F, Bottinger EP, Clarke R, Dedoussis G, Do R, Esko T, Eskola M, Farrall M, Gauguier D, Giedraitis V, Granger CB, Hall AS, Hamsten A, Hazen SL, Huang J, Kähönen M, Kyriakou T, Laaksonen R, Lind L, Lindgren C, Magnusson PK, Marouli E, Mihailov E, Morris AP, Nikus K, Pedersen N, Rallidis L, Salomaa V, Shah SH, Stewart AF, Thompson JR, Zalloua PA, Chambers JC, Collins R, Ingelsson E, Iribarren C, Karhunen PJ, Kooner JS, Lehtimäki T, Loos RJ, März W, McPherson R, Metspalu A, Reilly MP, Ripatti S, Sanghera DK, Thiery J, Watkins H, Deloukas P, Kathiresan S, Samani NJ, Schunkert H, Erdmann J, König IR. (2016). No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Scientific Reports, 6 (35278 ), 1−9.10.1038/srep35278.
5.1.
2016
Saar, Aet; Läll, Kristi; Alver, Maris; Fischer, Krista; Marandi, Toomas; Ainla, Tiia; Eha, Jaan (2016). Accuracy of PCE, SCORE and QRISK2 scores in predicting cardiovascular disease in Estonia, a high risk European country. European Heart Journal: ESC Congress 2016. Oxford University Press, 1217−1217.10.1093/eurheartj/ehw434.
1.1.
2015
Nikpay, M; Goel, A; Won, HH; Hall, LM; Willenborg, C; Kanoni, S; Saleheen, D; Kyriakou, T; Nelson, CP; Hopewell, JC; Webb, TR; Zeng, L; Dehghan, A; Alver, M; Armasu, SM; Auro, K; Bjonnes, A; Chasman, DI; Chen, S; Ford, I ... Farrall, M. (2015). A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nature Genetics, 47 (10), 1121−1130.10.1038/ng.3396.
1.1.
2015
Saar, Aet; Marandi, Toomas; Alver, Maris; Ainla, Tiia; Fischer, Krista; Eha, Jaan (2015). Südame isheemiatõve riski ennustamine geneetiliste markerite abil. Eesti Arst, 94 (9), 522−529.
1.3.
2015
Meren, Ülle Helena; Metspalu, Andres; Tammaru, Marika; Volmer, Daisy; Hedman, Anu; Alavere, Helene; Leitsalu, Liis; Läll, Kristi; Alver, Maris; Fischer, Krista (2015). Personaalse geneetilise riskiteabe mõju hüpertensiooniravi järgimusele ja tulemuslikkusele Eesti patsientidel: juhuslikustatud uuringu metoodika ülevaade. Eesti Arst, 94, 118−122.
1.1.
2014
Deelen, J; Beekman, M; Uh, HW; Broer, L; Ayers, KL; Tan, Q; Kamatani, Y; Bennet, AM; Tamm, R; Trompet, S; Guðbjartsson, DF; Flachsbart, F; Rose, G; Viktorin, A; Fischer, K; Nygaard, M; Cordell, HJ; Crocco, P; van den Akker, EB; Böhringer, S ... Slagboom, PE. (2014). Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics, 23 (16), 4420−4432.10.1093/hmg/ddu139.
6.7.
2012
Alver, Maris. (2012). Pikaealisuse ja vananemise geneetiliste markerite otsingul. (Tartu Ülikool). University of Tartu.
27.06.2019

Maris Alver

https://www.etis.ee/CV/Maris_Alver/eng
28.07.1986
737 4002
5138474
maris.alver@ut.ee

Career

Institution(s) and position(s)
01.10.2015–...   
University of Tartu, Estonian Genome Center , Specialist (1,00)
01.01.2018–09.07.2019   
University of Tartu, Institute of Genomics, Specialist (1,00)
01.08.2012–30.09.2015   
University of Tartu, Estonian Genome Center , Specialist (0,50)
2009–2009   
University of Tartu, Faculty of Science and Technology, Institute of Technology, lab technician (1,00)
2008–2009   
Estonian Biocentre, Senior Technician (0,10)
 
 
Education
2012–...   
Ph.D, molecular biomedicine, Tartu University
2010–2012   
Master's Degree, biomedicine, cum laude, Tartu University
2005–2009   
Bachelor's Degree, gene technology, Tartu University
1994–2005   
Tallinn English College
 
 
R&D related managerial and administrative work
2015−...   
Member of the Estonian Society of Human Genetics

Qualifications

Academic degrees
Maris Alver, Doctor's Degree, 2019, (sup) Andres Metspalu; Tõnu Esko, Value of genomics for atherosclerotic cardiovascular disease risk prediction, University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology.
Maris Alver, Master's Degree, 2012, (sup) Riin Tamm; Andres Metspalu, Pikaealisuse ja vananemise geneetiliste markerite otsingul (In quest of ageing and longevity associated genetic markers), University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Chair of Biotechnology.
 
 
Field of research
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS SPECIALITY: T490 Biotechnology
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.3. Genetics; CERCS SPECIALITY: B220 Genetics, cytogenetics
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine; CERCS SPECIALITY: B726 Clinical biology
FIELD OF RESEARCH: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS SPECIALITY: B110 Bioinformatics, medical informatics, biomathematics, biometrics
 
 

Projects in progress

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Saar, Aet; Läll, Kristi; Alver, Maris; Marandi, Toomas; Ainla, Tiia; Eha, Jaan; Metspalu, Andres; Fischer, Krista (2019). Estimating the performance of three cardiovascular disease risk scores: the Estonian Biobank cohort study. Journal of Epidemiology and Community Health.10.1136/jech-2017-209965 [forthcoming].
1.1.
2019
de Vries, Paul S; Brown, Michael R; Bentley, Amy R; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C (2019). Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology.10.1093/aje/kwz005 [forthcoming].
1.1.
2019
Kilpelainen, Tuomas O.; Bentley, Amy R.; Noordam, Raymond; Sung, Yun Ju; Schwander, Karen; Winkler, Thomas W.; Jakupovic, Hermina; Chasman, Daniel I.; Manning, Alisa; Ntalla, Ioanna; Aschard, Hugues; Brown, Michael R.; de las Fuentes, Lisa; Franceschini, Nora; Guo, Xiuqing; Vojinovic, Dina; Aslibekyan, Stella; Feitosa, Mary F.; Kho, Minjung; Musani, Solomon K. ... Loos, Ruth J. F. (2019). Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications, 10, ARTN 376.10.1038/s41467-018-08008-w.
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in medicine, 1−8.10.1038/s41436-018-0311-2 [forthcoming].
1.1.
2019
Adlam, David; Olson, Timothy M.; Combaret, Nicolas; Kovacic, Jason C.; Iismaa, Siiri E.; Al-Hussaini, Abtehale; O'Byrne, Megan M.; Bouajila, Sara; Georges, Adrien; Mishra, Ketan; Braund, Peter S.; d'Escamard, Valentina; Huang, Siying; Margaritis, Marios; Nelson, Christopher P.; de Andrade, Mariza; Kadian-Dodov, Daniella; Welch, Catherine A.; Mazurkiewicz, Stephani; Jeunemaitre, Xavier ... Bouatia-Naji, Nabila (2019). Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. Journal of the American College of Cardiology, 73 (1), 58−66.10.1016/j.jacc.2018.09.085.
1.1.
2019
Patel, Riyaz S.; Tragante, Vinicius; Schmidt, Amand F.; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behloui, Hassan; Boeckx, Bram; Braund, Peter S.; Breitling, Lutz P. ... Asselbergs, Folkert W. (2019). Subsequent Event Risk in Individuals With Established Coronary Heart Disease Design and Rationale of the GENIUS-CHD Consortium. Circulation. Genomic and Precision Medicine, 12 (4), ARTN e002470.10.1161/CIRCGEN.119.002470.
1.1.
2019
Patel, Riyaz S.; Schmidt, Amand F.; Tragante, Vinicius; McCubrey, Raymond O.; Holmes, Michael, V; Howe, Laurence J.; Direk, Kenan; Akerblom, Axel; Leander, Karin; Virani, Salim S.; Kaminski, Karol A.; Muehlschlegel, Jochen D.; Dube, Marie-Pierre; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina, V; Behlouli, Hassan; Boeckx, Bram; Braund, Peter S. ... Asselbergs, Folkert W. (2019). Association of Chromosome 9p21 With Subsequent Coronary Heart Disease Events A GENIUS-CHD Study of Individual Participant Data. Circulation. Genomic and Precision Medicine, 12 (4), 161−172.10.1161/CIRCGEN.119.002471.
1.1.
2018
Natarajan, Pradeep; Peloso, Gina M; Zekavat, Seyedeh Maryam; Montasser, May; Ganna, Andrea; Chaffin, Mark; Khera, Amit V; Zhou, Wei; Bloom, Jonathan M; Engreitz, Jesse M; Ernst, Jason; O'Connell, Jeffrey R; Ruotsalainen, Sanni E; Alver, Maris; Manichaikul, Ani; Johnson, W Craig; Perry, James A; Poterba, Timothy; Seed, Cotton; Surakka, Ida L ... , (2018). Deep-coverage whole genome sequences and blood lipids among 16,324 individuals. Nature Communications, 9 (1), 3391−3391.10.1038/s41467-018-05747-8.
1.1.
2018
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
1.1.
2018
Zekavat, Seyedeh M; Ruotsalainen, Sanni; Handsaker, Robert E; Alver, Maris; Bloom, Jonathan; Poterba, Timothy; Seed, Cotton; Ernst, Jason; Chaffin, Mark; Engreitz, Jesse; Peloso, Gina M; Manichaikul, Ani; Yang, Chaojie; Ryan, Kathleen A; Fu, Mao; Johnson, W Craig; Tsai, Michael; Budoff, Matthew; Vasan, Ramachandran S; Cupples, L Adrienne ... , (2018). Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries. Nature Communications, 9 (1), 2606−2606.10.1038/s41467-018-04668-w.
1.1.
2018
Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
1.1.
2017
Webb, Thomas R.; Erdmann, Jeanette; Stirrups, Kathleen E.; Stitziel, Nathan O.; Masca, Nicholas G. D.; Jansen, Henning; Kanoni, Stavroula; Nelson, Christopher P.; Ferrario, Paola G.; Koenig, Inke R.; Eicher, John D.; Johnson, Andrew D.; Hamby, Stephen E.; Betsholtz, Christer; Ruusalepp, Arno; Franzen, Oscar; Schadt, Eric E.; Bjoerkegren, Johan L. M.; Weeke, Peter E.; Auer, Paul L. ... Kathiresan, Sekar (2017). Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease. Journal of the American College of Cardiology, 7, 823−836.10.1016/j.jacc.2016.11.056.
1.1.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 3, 403−415.10.1038/ng.3768.
1.1.
2016
Stitziel, Nathan O; Stirrups, Kathleen E; Masca, Nicholas G D; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E; Webb, Thomas R; Auer, Paul L; Schick, Ursula M; Lu, Yingchang; Zhang, He; Dube, Marie-Pierre; Goel, Anuj; Farrall, Martin; Peloso, Gina M; Won, Hong-Hee; Do, Ron; van Iperen, Erik ... Schunkert, Heribert. (2016). Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease. New England Journal of Medicine, 374 (12), 1134−1144.10.1056/NEJMoa1507652.
1.1.
2016
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium. (2016). Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science, 351 (6278), 1166−1171.10.1126/science.aad3517.
1.1.
2016
Elosua, Roberto; Lluís-Ganella, Carla; Subirana, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin; Sayols-Baixeras, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí, Mariano; Siscovick, David; Melander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat, Jaume (2016). Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater than the Parts? A Genetic Approach. Circulation. Cardiovascular genetics, 9 (3), 279−286.
1.1.
2016
Loley C, Alver M, Assimes TL, Bjonnes A, Goel A, Gustafsson S, Hernesniemi J, Hopewell JC, Kanoni S, Kleber ME, Lau KW, Lu Y, Lyytikäinen LP, Nelson CP, Nikpay M, Qu L, Salfati E, Scholz M, Tukiainen T, Willenborg C, Won HH, Zeng L, Zhang W, Anand SS, Beutner F, Bottinger EP, Clarke R, Dedoussis G, Do R, Esko T, Eskola M, Farrall M, Gauguier D, Giedraitis V, Granger CB, Hall AS, Hamsten A, Hazen SL, Huang J, Kähönen M, Kyriakou T, Laaksonen R, Lind L, Lindgren C, Magnusson PK, Marouli E, Mihailov E, Morris AP, Nikus K, Pedersen N, Rallidis L, Salomaa V, Shah SH, Stewart AF, Thompson JR, Zalloua PA, Chambers JC, Collins R, Ingelsson E, Iribarren C, Karhunen PJ, Kooner JS, Lehtimäki T, Loos RJ, März W, McPherson R, Metspalu A, Reilly MP, Ripatti S, Sanghera DK, Thiery J, Watkins H, Deloukas P, Kathiresan S, Samani NJ, Schunkert H, Erdmann J, König IR. (2016). No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis. Scientific Reports, 6 (35278 ), 1−9.10.1038/srep35278.
5.1.
2016
Saar, Aet; Läll, Kristi; Alver, Maris; Fischer, Krista; Marandi, Toomas; Ainla, Tiia; Eha, Jaan (2016). Accuracy of PCE, SCORE and QRISK2 scores in predicting cardiovascular disease in Estonia, a high risk European country. European Heart Journal: ESC Congress 2016. Oxford University Press, 1217−1217.10.1093/eurheartj/ehw434.
1.1.
2015
Nikpay, M; Goel, A; Won, HH; Hall, LM; Willenborg, C; Kanoni, S; Saleheen, D; Kyriakou, T; Nelson, CP; Hopewell, JC; Webb, TR; Zeng, L; Dehghan, A; Alver, M; Armasu, SM; Auro, K; Bjonnes, A; Chasman, DI; Chen, S; Ford, I ... Farrall, M. (2015). A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease. Nature Genetics, 47 (10), 1121−1130.10.1038/ng.3396.
1.1.
2015
Saar, Aet; Marandi, Toomas; Alver, Maris; Ainla, Tiia; Fischer, Krista; Eha, Jaan (2015). Südame isheemiatõve riski ennustamine geneetiliste markerite abil. Eesti Arst, 94 (9), 522−529.
1.3.
2015
Meren, Ülle Helena; Metspalu, Andres; Tammaru, Marika; Volmer, Daisy; Hedman, Anu; Alavere, Helene; Leitsalu, Liis; Läll, Kristi; Alver, Maris; Fischer, Krista (2015). Personaalse geneetilise riskiteabe mõju hüpertensiooniravi järgimusele ja tulemuslikkusele Eesti patsientidel: juhuslikustatud uuringu metoodika ülevaade. Eesti Arst, 94, 118−122.
1.1.
2014
Deelen, J; Beekman, M; Uh, HW; Broer, L; Ayers, KL; Tan, Q; Kamatani, Y; Bennet, AM; Tamm, R; Trompet, S; Guðbjartsson, DF; Flachsbart, F; Rose, G; Viktorin, A; Fischer, K; Nygaard, M; Cordell, HJ; Crocco, P; van den Akker, EB; Böhringer, S ... Slagboom, PE. (2014). Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics, 23 (16), 4420−4432.10.1093/hmg/ddu139.
6.7.
2012
Alver, Maris. (2012). Pikaealisuse ja vananemise geneetiliste markerite otsingul. (Tartu Ülikool). University of Tartu.
27.06.2019