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Mattias Hällbrink

https://www.etis.ee/CV/Mattias_Hällbrink/est
10.05.1973
+46705906866
mattias@neurochem.su.se

Teenistuskäik

Töökohad ja ametid
01.01.2008–31.12.2009   
Neurokeemia ja neurotoksikoloogia teaduskond, Stockholmi Ülikool, teadur-õppejõud 0.5 kohta
01.01.2003–31.12.2008   
Neurokeemia ja neurotoksikoloogia teaduskond, Stockholmi Ülikool, teadur
01.01.2001–31.12.2002   
CePep AB, teaduslik konsultant
01.01.2000–31.12.2000   
Neurofarmakoloogia teaduskond, Scripps uurimisinstituut, La Jolla, CA, USA, külalisteadur
 
 
Haridustee
2003–2009   
Neurokeemia ja neurotokskoloogia teaduskond, Stockholmi Ülikool, teadur
2002–2002   
Molekulaarse Farmakoloogia uurimiskeskus, Peptiidi keemia teaduskond, Berliin, Saksama, postdoc
1997–2000   
Neurokeemia ja Neurotoksikoloogia teaduskond, Stockholmi Ülikool, Rootsi, PhD
1992–1996   
Stockholmi Ülikool, BSc, keemia
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2003−2008   
Neurokeemia kursus, edasijõudnutele, lektor ja kursuse administraator
2003−2008   
Neurokeemia teaduskonna seminaride korraldaja, bakalauruse üliõpilastele
2003−2008   
Neurokeemia ja neurotoksikoloogia teaduskonna juhatuse liige
2003−2007   
Neurokeemia ja neurotoksikoloogia teaduskond, juhataja ülesannete asetäitja

Kvalifikatsioon

Teaduskraadid
Mattias Hällbrink, doktorikraad, 2000, (juh) Ülo Langel, Cell-penetarting peptides. Mechanisms and applications, The Department of Neurochemistry and Neurotoxicology, Stockholm University.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; TÄPSUSTUS: Rakku läbivad peptiidid ja nende mehhanismide uurimine ja rakendus

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2009
Palm-Apergi, C.; Lorents, A.; Padari, K.; Pooga, M.; Hällbrink, M. (2009). The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake. The FASEB Journal, 23 (1), 214−223. DOI: 10.1096/fj.08-110254.
1.1.
2008
Palm-Apergi, C.; Hällbrink, M. (2008). A new rapid cell-penetraiting peptide based strategy to produce bacterial ghosts for plasmid delivery. Journal of Controlled Release, 132 (1), 49−54. DOI: 10.1016/j.jconrel.2008.08.011.
1.1.
2007
Palm, C.; Jayamanne, M.; Kjellander, M.; Hällbrink, M. (2007). Peptide degradation is acritical determinant for cell-penetarting peptide uptake. Biochimica et Biophysica Acta - Biomembranes, 1768, 7, 1769−1776.
1.1.
2006
Palm, C.; Netzereab, S.; Hällbrink, M. (2006). Quantitatively determined uptake of cell-penetrating peptides in non-mammalian cells with an evaluation of degradation and antimicrobal effects. Peptides, 27, 7, 1710−1716.
1.1.
2006
Lindgren, M.; Rosenthal-Aizman, K.; Saar, K.; Eiriksdottir, E.; Jiang, Y.; Sassian, M.; Ostlund, P.; Hällbrink, M.; Langel, U. (2006). Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide. Biochemical Pharmacology, 71 (4), 416−425.
3.1.
2006
Hällbrink, M.; Langel, Ü. (2006). Prediction of cell-penetrating peptides and prodrug approach. In: Langel, Ü. (_EditorsAbbr). Handbook of Cell-Penetrating Peptides, 2nd edition (77−85).. CRC Press Inc.
1.1.
2005
Holm, T.; Netzereab, S.; Hansen, M.; Langel, Ü.; Hällbrink, M. (2005). Uptake of cell-penetrating peptides in yeasts. FEBS Letters, 579 (23), 5217−5222.
1.1.
2004
Nekhotiaeva, N.; Elmquist, A.; Rajarao, GK.; Hällbrink, M.; Langel, Ü.; Good, L. (2004). Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides. The FASEB Journal, 18 (2), 394−396.
1.1.
2004
Lindgren, M.; Hällbrink, M.; Elmquist, A.; Langel, Ü. (2004). Passage of cell-penetrating peptides across a human epithelial cell layer in vitro. Biochemical Journal, 377 (1), 69−76.
1.1.
2003
Bavec, J.; Hällbrink, M.; Olsson, M.; Langel, Ü.; Zorko, M. (2003). Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling. Regulatory Peptides, 111, 137−144.
1.1.
2002
Östenson, CG.; Sandberg-Nordquist, AC.; Chen, J.; Hällbrink, M.; Rotin, D.; Langel, Ü.; Efendic, S. (2002). Overexpression of protein-tyrosine phosphotase PTPo is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochemical and Biophysical Research Communications, 291 (4), 945−950.
1.1.
2002
Lundberg, P.; Magzoub, M.; Lindberg, M.; Hällbrink, M.; Jarvet, J.; Eriksson, L.E.G.; Langel, Ü.; Gräslund, A. (2002). Cell membrane translocation of the N-terminal (1–28) part of the prion protein. Biochemical and Biophysical Research Communications, 299 (1), 85−90.
3.1.
2002
Hällbrink, M.; Langel, Ü. (2002). Comparison of gargo delivery efficiency of cell-penetrating peptides. In: Epton, R. (_EditorsAbbr). Innovation and Perspectives in Solid phase Synthesis and Combinatorial Libraries (165−168).. Southampton: Mayflower Worldwide.
3.1.
2002
Lindgren, M.; Hällbrink, M.; Langel, Ü. (2002). Quantification of cell-penetrating peptides and their cargoes. In: Langel, Ü. (_EditorsAbbr). Cell penetrating Peptides. Processes and Applications (263−275).. CRC Press Inc.
3.1.
2002
Zorko, M.; Hällbrink, M.; Langel, Ü. (2002). Kinetics of uptake of cell-penetrating peptides. In: Langel, Ü (_EditorsAbbr). Cell Penetrating Peptides. Processes and Applications (277−293).. CRC Press Inc.
3.1.
2002
Pooga, M.; Hällbrink, M.; Langel, Ü. (2002). Transportans. In: Langel, Ü. (Ed.). Cell penetrating peptides : processes and applications (53−70). . Boca Raton, FL: CRC Press Inc.
1.1.
2001
Hällbrink, M.; Floren, A.; Elmquist, A.; Pooga, M.; Bartfai, T.; Langel, Ü. (2001). Cargo delivery kinetics of cell-penetrating peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1515 (2), 101−109.
1.1.
2001
Hällbrink, M.; Holmqvist, T.; Olsson, M.; Östenson, CG.; Efendic, S.; Langel, Ü. (2001). Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galfas and Galfai/Galfao activation. Biochimica et Biophysica Acta, 1546 (1), 79−86.
1.1.
2000
Lindgren, M.; Hällbrink, M.; Prochiantz, A.; Langel, Ü. (2000). Cell penetrating peptides. Trends in Pharmacological Sciences, 21 (3), 99−103.
1.1.
1998
Pooga, M.; Lindgren, M.; Hällbrink, M.; Bråkenhielm, E.; Langel, Ü. (1998). Galanin-Based Peptides, Galparan and Transportan, with Receptor-Dependent and Independent Activities. Annals of New York Academy of Sciences, 863, 450−453.
1.1.
1998
Pooga, M.; Hällbrink, M.; Zorko, M.; Langel, Ü. (1998). Cell penetration by transportan. The FASEB Journal, 12 (1), 67−77.
1.2.
1998
Soomets, U.; Hällbrink, M.; Zorko, M.; Langel, Ü. (1998). From galanin and mastoparan to galparan and transportan. Current Topics in Peptide and Protein Research, 2, 83−113.
1.2.
1998
Longland, C.; Mezna, M.; Langel, Ü.; Hällbrink, M.; Soomets, U.; Wheatley, M.; Michelangeli, F.; Howl, J. (1998). Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs. Cell Calcium, 24 (1), 27−34.
1.2.
1997
Mezna, M.; Langel, Ü.; Hällbrink, M.; Wheatley, M.; Michelangeli, M.; Howl, J. (1997). Calcium-mobilizing actions of chimeric hormone-mastoparan peptides. Biochemical Society Transactions, 25 (2), 450S.
1.2.
1997
Soomets, U.; Hällbrink, M.; Zorko, M.; Langel, Ü. (1997). From galanin and mastoparan to galparan and transportan. Current Topics in Peptide and Protein Research, 2, 83−113.
25.11.2020

Mattias Hällbrink

https://www.etis.ee/CV/Mattias_Hällbrink/eng
10.05.1973
+46705906866
mattias@neurochem.su.se

Career

Institutions and positions
01.01.2008–31.12.2009   
The Department of Neurochemistry and Neurotoxicology, Stockholm University, Assistant Professor part time teacher
01.01.2003–31.12.2008   
The Department of Neurochemistry and Neurotoxicology, Stockholm University, Assistant Professor
01.01.2001–31.12.2002   
CePep AB, research consultant
01.01.2000–31.12.2000   
The Department of Neuropharmacology, The Scripps research institute, La Jolla, CA, USA, visiting scientist
 
 
Education
2003–2009   
The Department of Neurochemistry and Neurotoxicology, Stockholm University, Assistant Professor
2002–2002   
The Research Center for Molecular Pharmacology, Department of peptide chemistry, Berlin, Germany, post-doc
1997–2000   
The Department of Neurochemistry and Neurotoxicology, Stockholm University, Sweden, PhD
1992–1996   
Stockholm University, Undergraduate studies in Chemistry
 
 
R&D related managerial and administrative work
2003−2008   
Course administrator and lector for advanced Neurochemistry course
2003−2008   
Course administrator for seminars in Neurochemistry, graduate student level
2003−2008   
The Depratment of Neurochemistry and Neurotoxicology, member of the faculty board
2003−2007   
The Department of Neurochemistry and Neurotoxicology periodically acting chairman

Qualifications

Academic degrees
Mattias Hällbrink, Doctor's Degree, 2000, (sup) Ülo Langel, Cell-penetarting peptides. Mechanisms and applications, The Department of Neurochemistry and Neurotoxicology, Stockholm University.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; SPECIFICATION: Cell penetrating peptides. Mechanisms and applications.
 
 

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2009
Palm-Apergi, C.; Lorents, A.; Padari, K.; Pooga, M.; Hällbrink, M. (2009). The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake. The FASEB Journal, 23 (1), 214−223. DOI: 10.1096/fj.08-110254.
1.1.
2008
Palm-Apergi, C.; Hällbrink, M. (2008). A new rapid cell-penetraiting peptide based strategy to produce bacterial ghosts for plasmid delivery. Journal of Controlled Release, 132 (1), 49−54. DOI: 10.1016/j.jconrel.2008.08.011.
1.1.
2007
Palm, C.; Jayamanne, M.; Kjellander, M.; Hällbrink, M. (2007). Peptide degradation is acritical determinant for cell-penetarting peptide uptake. Biochimica et Biophysica Acta - Biomembranes, 1768, 7, 1769−1776.
1.1.
2006
Palm, C.; Netzereab, S.; Hällbrink, M. (2006). Quantitatively determined uptake of cell-penetrating peptides in non-mammalian cells with an evaluation of degradation and antimicrobal effects. Peptides, 27, 7, 1710−1716.
1.1.
2006
Lindgren, M.; Rosenthal-Aizman, K.; Saar, K.; Eiriksdottir, E.; Jiang, Y.; Sassian, M.; Ostlund, P.; Hällbrink, M.; Langel, U. (2006). Overcoming methotrexate resistance in breast cancer tumour cells by the use of a new cell-penetrating peptide. Biochemical Pharmacology, 71 (4), 416−425.
3.1.
2006
Hällbrink, M.; Langel, Ü. (2006). Prediction of cell-penetrating peptides and prodrug approach. In: Langel, Ü. (_EditorsAbbr). Handbook of Cell-Penetrating Peptides, 2nd edition (77−85).. CRC Press Inc.
1.1.
2005
Holm, T.; Netzereab, S.; Hansen, M.; Langel, Ü.; Hällbrink, M. (2005). Uptake of cell-penetrating peptides in yeasts. FEBS Letters, 579 (23), 5217−5222.
1.1.
2004
Nekhotiaeva, N.; Elmquist, A.; Rajarao, GK.; Hällbrink, M.; Langel, Ü.; Good, L. (2004). Cell entry and antimicrobial properties of eukaryotic cell-penetrating peptides. The FASEB Journal, 18 (2), 394−396.
1.1.
2004
Lindgren, M.; Hällbrink, M.; Elmquist, A.; Langel, Ü. (2004). Passage of cell-penetrating peptides across a human epithelial cell layer in vitro. Biochemical Journal, 377 (1), 69−76.
1.1.
2003
Bavec, J.; Hällbrink, M.; Olsson, M.; Langel, Ü.; Zorko, M. (2003). Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling. Regulatory Peptides, 111, 137−144.
1.1.
2002
Östenson, CG.; Sandberg-Nordquist, AC.; Chen, J.; Hällbrink, M.; Rotin, D.; Langel, Ü.; Efendic, S. (2002). Overexpression of protein-tyrosine phosphotase PTPo is linked to impaired glucose-induced insulin secretion in hereditary diabetic Goto-Kakizaki rats. Biochemical and Biophysical Research Communications, 291 (4), 945−950.
1.1.
2002
Lundberg, P.; Magzoub, M.; Lindberg, M.; Hällbrink, M.; Jarvet, J.; Eriksson, L.E.G.; Langel, Ü.; Gräslund, A. (2002). Cell membrane translocation of the N-terminal (1–28) part of the prion protein. Biochemical and Biophysical Research Communications, 299 (1), 85−90.
3.1.
2002
Hällbrink, M.; Langel, Ü. (2002). Comparison of gargo delivery efficiency of cell-penetrating peptides. In: Epton, R. (_EditorsAbbr). Innovation and Perspectives in Solid phase Synthesis and Combinatorial Libraries (165−168).. Southampton: Mayflower Worldwide.
3.1.
2002
Lindgren, M.; Hällbrink, M.; Langel, Ü. (2002). Quantification of cell-penetrating peptides and their cargoes. In: Langel, Ü. (_EditorsAbbr). Cell penetrating Peptides. Processes and Applications (263−275).. CRC Press Inc.
3.1.
2002
Zorko, M.; Hällbrink, M.; Langel, Ü. (2002). Kinetics of uptake of cell-penetrating peptides. In: Langel, Ü (_EditorsAbbr). Cell Penetrating Peptides. Processes and Applications (277−293).. CRC Press Inc.
3.1.
2002
Pooga, M.; Hällbrink, M.; Langel, Ü. (2002). Transportans. In: Langel, Ü. (Ed.). Cell penetrating peptides : processes and applications (53−70). . Boca Raton, FL: CRC Press Inc.
1.1.
2001
Hällbrink, M.; Floren, A.; Elmquist, A.; Pooga, M.; Bartfai, T.; Langel, Ü. (2001). Cargo delivery kinetics of cell-penetrating peptides. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1515 (2), 101−109.
1.1.
2001
Hällbrink, M.; Holmqvist, T.; Olsson, M.; Östenson, CG.; Efendic, S.; Langel, Ü. (2001). Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galfas and Galfai/Galfao activation. Biochimica et Biophysica Acta, 1546 (1), 79−86.
1.1.
2000
Lindgren, M.; Hällbrink, M.; Prochiantz, A.; Langel, Ü. (2000). Cell penetrating peptides. Trends in Pharmacological Sciences, 21 (3), 99−103.
1.1.
1998
Pooga, M.; Lindgren, M.; Hällbrink, M.; Bråkenhielm, E.; Langel, Ü. (1998). Galanin-Based Peptides, Galparan and Transportan, with Receptor-Dependent and Independent Activities. Annals of New York Academy of Sciences, 863, 450−453.
1.1.
1998
Pooga, M.; Hällbrink, M.; Zorko, M.; Langel, Ü. (1998). Cell penetration by transportan. The FASEB Journal, 12 (1), 67−77.
1.2.
1998
Soomets, U.; Hällbrink, M.; Zorko, M.; Langel, Ü. (1998). From galanin and mastoparan to galparan and transportan. Current Topics in Peptide and Protein Research, 2, 83−113.
1.2.
1998
Longland, C.; Mezna, M.; Langel, Ü.; Hällbrink, M.; Soomets, U.; Wheatley, M.; Michelangeli, F.; Howl, J. (1998). Biochemical mechanisms of calcium mobilisation induced by mastoparan and chimeric hormone-mastoparan constructs. Cell Calcium, 24 (1), 27−34.
1.2.
1997
Mezna, M.; Langel, Ü.; Hällbrink, M.; Wheatley, M.; Michelangeli, M.; Howl, J. (1997). Calcium-mobilizing actions of chimeric hormone-mastoparan peptides. Biochemical Society Transactions, 25 (2), 450S.
1.2.
1997
Soomets, U.; Hällbrink, M.; Zorko, M.; Langel, Ü. (1997). From galanin and mastoparan to galparan and transportan. Current Topics in Peptide and Protein Research, 2, 83−113.
25.11.2020

Otsi projekti

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Asutus on projekti finantseerija   Asutus on projekti teostaja  
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Kõik   Tavaprojektid   Ülemprojektid   Alamprojektid  
Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
Lõppenud
Algus
Hajus
Täpne
Lihtotsing Tühjenda
  • Leitud 1 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0180027s08Koespetsiifilised transportvektorid01.01.200831.12.2013Ülo LangelTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut600 272,61 EUR