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Pärt Peterson

https://www.etis.ee/CV/Pärt_Peterson/est
18.04.1966
737 4202
part.peterson@ut.ee
ResearcherID: A-5788-2009

Teenistuskäik

Töökohad ja ametid
01.02.2019–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, molekulaarimmunoloogia professor (1,00)
11.01.2016–10.01.2021   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, osakonna juhataja
1992-1994, Biotehnoloogia instituut, Tampere Ülikool
1995-2000, Meditsiinitehnoloogia instituut Tampere Ülikool
2000-2003 Soome Akadeemia teadur
2003- Erakorraline professor, Tartu Ülikooli arstiteaduskond
01.01.2018–31.01.2019   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, molekulaarimmunoloogia juhtivteadur (0,50)
01.01.2016–10.01.2016   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, osakonna juhataja
01.01.2016–31.12.2017   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, molekulaarimmunoloogia juhtivteadur (0,50)
01.01.2016–31.01.2019   
Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut, molekulaarimmunoloogia professor (0,50)
01.11.2014–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, molekulaarimmunoloogia juhtivteadur (0,50)
01.11.2014–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, molekulaarimmunoloogia professor (0,50)
01.09.2013–31.12.2015   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, osakonna juhataja
01.09.2013–31.10.2014   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, molekulaarse immunoloogia professor (0,50)
18.06.2013–31.08.2013   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, osakonna juhataja
22.05.2013–03.06.2013   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, instituudi juhataja kohusetäitja
21.05.2013–31.10.2014   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, molekulaarse immunoloogia juhtivteadur (0,50)
21.05.2013–31.08.2013   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, molekulaarse immunoloogia professor (0,50)
01.01.2013–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, molekulaarse immunoloogia juhtivteadur (0,50)
01.01.2013–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, molekulaarse immunoloogia professor (0,50)
23.12.2012–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, instituudi juhataja
01.03.2011–22.12.2012   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, instituudi juhataja
2010–2012   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, Juhataja (0,20)
01.04.2009–22.12.2012   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, uurija-professor (1,00)
01.09.2008–31.12.2012   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, molekulaarse immunoloogia professor (1,00)
2008–2012   
Eesti Teaduste Akadeemia, Uurija-professor (1,00)
01.09.2006–31.08.2008   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, erakorraline professor (1,00)
01.09.2003–31.08.2006   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, erakorraline professor (1,00)
 
 
Haridustee
1992–1996   
Filosoofiadoktor (PhD) Immunoloogia, Tampere Ülikool, 1996
1991–1992   
Magister (MSc), Bioloogiateaduskond, Tartu Ülikool, 1992
1984–1991   
Bioloogiateaduskond, Tartu Ülikool 1991
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2016−...   
Eesti Immunoloogide ja Allergoloogide Seltsi (EIAS) juhatuse liige
2015−...   
TÜ Bio- ja Siirdemeditsiini Instituudi nõukogu esimees
2015−...   
Frontiers in Immunology ajakirja toimetuskolleegiumi liige
2013−...   
European Journal of Immunology ajakirja toimetuskolleegiumi liige
2011−...   
Scandinavian Journal of Immunology ajakirja toimetuskolleegiumi liige
2003−...   
Eesti Inimesegeneetikaühingu liige
2013−2015   
Eesti Teadusagentuuri Hindamisnõukogu liige
2009−2012   
Teaduskompetentsi nõukogu liige
2007−2015   
TÜ Molekulaar- ja Rakubioloogia instituudi nõukogu liige
2004−2009   
Eesti Inimesegeneetikaühingu juhatuse liige
2000−2003   
Institute of Medical Technology, (University of Tampere) nôukogu liige
2000−2003   
Tampere Graduate School in Biomedicine and Biotechnology (TGSBB) Evaluation Board’i liige

Kvalifikatsioon

Teaduskraadid
Pärt Peterson, doktorikraad, 1996, (juh) Kai Krohn, Disease-associated antigens and HLA in autoimmune Addison’s disease and polyglandular syndromes, Tampere Ülikool.
Pärt Peterson, magistrikraad (teaduskraad), 1992, (juh) Ain Heinaru; Kai Krohn, Identification of autoantigenic B-cell epitopes on human steroid 17a-hydroxylase, an autoantigen of Addison's disease in type I polyglandular syndrome, Tartu Ülikool, Bioloogia-geograafiateaduskond.
 
 
Teaduspreemiad ja tunnustused
2009, Pärt Peterson, Riigi teaduspreemia publikatsioonide tsükli “Tsentraalse immuuntolerantsuse molekulaarsed mehhanismid” eest
 
 
Teadustöö põhisuunad
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin; PÕHISUUND: Autoimmuunsuses osalevad geenid, tüümuse diferentseerumine, immuunne tolerantsus, T rakkude selektsioon, DNA metüültransferaasid, imprinting
 
 
Lisainfo
MSc
PhD (immunoloogia)
Dotsent (molekulaarimmunoloogia)
Tartu Ülikool, 1992
Tampere Ülikool, 1996
Tampere Ülikool, 1998

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Kaleviste, Epp; Saare, Mario; Leahy, Timothy Ronan; Bondet, Vincent; Duffy, Darragh; Mogensen, Trine; Jørgensen, Sofie E; Nurm, Helke; Ip, Winnie; Davies, E Graham; Sauer, Sascha; Syvänen, Ann-Christine; Milani, Lili; Peterson, Pärt; Kisand, Kai (2019). Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined. European Journal of Immunology.10.1002/eji.201847955 [ilmumas].
1.1.
2018
Rodrigues, Pedro M.; Peterson, Part; Alves, Nuno L. (2018). Setting Up the Perimeter of Tolerance: Insights into mTEC Physiology. Trends in Immunology, 39 (1), 2−5.10.1016/j.it.2017.11.001.
1.1.
2018
Lalić, Ivana M.; Bichele, Rudolf; Repar, Anja; Despotović, Sanja Z; Petričević, Saša; Laan, Martti; Peterson, Pärt; Westermann, Jürgen; Milićević, Živana; Mirkov, Ivana; Milićević, Novica M. (2018). Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 216, 125−134.10.1016/j.aanat.2017.12.002.
1.1.
2018
Bichele, R.; Kärner, J.; Truusalu, K.; Smidt, I.; Mändar, R.; Conti, HR.; Gaffen, SL.; Peterson, P.; Laan, M.; Kisand, K. (2018). IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model. European Journal of Immunology, 48 (3), 464−470.10.1002/eji.201747209.
1.1.
2018
Ossart, Jason; Moreau, Anne; Autrusseau, Elodie; Ménoret, Séverine; Martin, Jérôme C; Besnard, Marine; Ouisse, Laure-Hélène; Tesson, Laurent; Flippe, Léa; Kisand, Kai; Peterson, Pärt; Hubert, François-Xavier; Anegon, Ignacio; Josien, Régis; Guillonneau, Carole (2018). Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. Journal of immunology (Baltimore, Md. : 1950), 201 (3), 874−887.10.4049/jimmunol.1701318.
1.1.
2017
Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, Tasa T, Metspalu A, Milani L, Peterson P. (2017). DNA breaks and chromatin structural changes enhance the transcription of Autoimmune Regulator target genes. Journal of Biological Chemistry, 292 (16), 6542−6554.jbc.M116.764704.
1.1.
2017
Lepik, Kaido; Annilo, Tarmo; Kukuškina, Viktorija; eQTLGen Consortium; Kisand, Kai; Kutalik, Zoltán; Peterson, Pärt; Peterson, Hedi (2017). C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLoS Computational Biology, 13 (9), e1005766−e1005766.10.1371/journal.pcbi.1005766.
1.1.
2017
Fishman, Dmytro; Kisand, Kai; Hertel, Christina; Rothe, Mike; Remm, Anu; Pihlap, Maire; Adler, Priit; Vilo, Jaak; Peet, Aleksandr; Meloni, Antonella; Podkrajsek, Katarina Trebusak; Battelino, Tadej; Bruserud, Øyvind; Wolff, Anette S B; Husebye, Eystein S; Kluger, Nicolas; Krohn, Kai; Ranki, Annamari; Peterson, Hedi; Hayday, Adrian ... Peterson, Pärt (2017). Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Frontiers in Immunology, 8, 976−976.10.3389/fimmu.2017.00976.
1.1.
2017
Hermann, Helen; Runnel, Toomas; Aab, Alar; Baurecht, Hansjörg; Rodriguez, Elke; Magilnick, Nathaniel; Urgard, Egon; Šahmatova, Liisi; Prans, Ele; Maslovskaja, Julia; Abram, Kristi; Karelson, Maire; Kaldvee, Bret; Reemann, Paula; Haljasorg, Uku; Rückert, Beate; Wawrzyniak, Paulina; Weichenthal, Michael; Mrowietz, Ulrich; Franke, Andre ... (2017). miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis. The Journal of Investigative Dermatology.10.1016/j.jid.2017.05.012.
1.1.
2017
Šahmatova, Liisi; Sügis, Elena; Šunina, Marina; Hermann, Helen; Prans, Ele; Pihlap, Maire; Abram, Kristi; Rebane, Ana; Peterson, Hedi; Peterson, Pärt; Kingo, Külli; Kisand, Kai (2017). Signs of innate immune activation and premature immunosenescence in psoriasis patients. Scientific Reports, 7 (1), 7553−7553.10.1038/s41598-017-07975-2.
1.1.
2017
Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Andrä, Immanuel; Annunziato, Francesco; Bacher, Petra; Barnaba, Vincenzo; Battistini, Luca; Bauer, Wolfgang M; Baumgart, Sabine; Becher, Burkhard; Beisker, Wolfgang; Berek, Claudia; Blanco, Alfonso; Borsellino, Giovanna; Boulais, Philip E; Brinkman, Ryan R; Büscher, Martin; Busch, Dirk H; Bushnell, Timothy P ... Zimmermann, Jakob (2017). Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology, 47 (10), 1584−1797.10.1002/eji.201646632.
1.1.
2017
Kasela, Silva; Kisand, Kai; Tserel, Liina; Kaleviste, Epp; Remm, Anu; Fischer, Krista; Esko, Tõnu; Westra, Harm-Jan; Fairfax, Benjamin P; Makino, Seiko; Knight, Julian C; Franke, Lude; Metspalu, Andres; Peterson, Pärt; Milani, Lili (2017). Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells. Plos Genetics, 13 (3, 3), ARTN e1006643.10.1371/journal.pgen.1006643.
1.1.
2016
Hetemäki, Iivo; Jarva, Hanna; Kluger, Nicolas; Baldauf, Hanna-Mari; Laakso, Sini; Bratland, Eirik; Husebye, Eystein S; Kisand, Kai; Ranki, Annamari; Peterson, Pärt; Arstila, T Petteri (2016). Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients. Journal of immunology (Baltimore, Md. : 1950), 196 (7), 2955−2964.10.4049/jimmunol.1500301.
1.1.
2016
Bichele, Rudolf; Kisand, Kai; Peterson, Pärt; Laan, Martti (2016). TNF superfamily members play distinct roles in shaping the thymic stromal microenvironment. Molecular Immunology, 72, 92−102.10.1016/j.molimm.2016.02.015.
1.1.
2016
Limbach, Maia; Saare, Mario; Tserel, Liina; Kisand, Kai; Eglit, Triin; Sauer, Sascha; Axelsson, Tomas; Syvänen, Ann-Christine; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2016). Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. Journal of Autoimmunity, 67, 46−56.10.1016/j.jaut.2015.09.006.
1.1.
2016
Laan, Martti; Haljasorg, Uku; Kisand, Kai; Salumets, Andres; Peterson, Pärt (2016). Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing. European Journal of Immunology, 46 (8), 2008−2017.10.1002/eji.201646309.
1.1.
2016
Meyer, Steffen; Woodward, Martin; Hertel, Christina; Vlaicu, Philip; Haque, Yasmin; Kärner, Jaanika; Macagno, Annalisa; Onuoha, Shimobi C; Fishman, Dmytro; Peterson, Hedi; Metsküla, Kaja; Uibo, Raivo; Jäntti, Kirsi; Hokynar, Kati; Wolff, Anette S B; ,; Krohn, Kai; Ranki, Annamari; Peterson, Pärt; Kisand, Kai ... Hayday, Adrian (2016). AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell, 166 (3), 582−595.10.1016/j.cell.2016.06.024.
1.1.
2015
Kõks, Gea; Uudelepp, Mari-Liis; Limbach, Maia; Peterson, Pärt; Reimann, Ene; Kõks, Sulev (2015). Smoking-Induced Expression of the GPR15 Gene Indicates Its Potential Role in the Chronic Inflammatory Pathologies. The American journal of pathology, 185 (11), 2898−2906.10.1016/j.ajpath.2015.07.006.
1.1.
2015
Kisand, K; Peterson, P (2015). Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy. Journal of Clinical Immunology, 35 (5), 463−478.10.1007/s10875-015-0176-y.
1.1.
2015
Westra, HJ; Arends, D; Esko, T; Peters, MJ; Schurmann, C; Schramm, K; Kettunen, J; Yaghootkar, H; Fairfax, BP; Andiappan, AK; Li, Y; Fu, J; Karjalainen, J; Platteel, M; Visschedijk, M; Weersma, RK; Kasela, S; Milani, L; Tserel, L; Peterson, P ... Franke, L. (2015). Cell Specific eQTL Analysis without Sorting Cells. Plos Genetics, 11 (5), e1005223.10.1371/journal.pgen.1005223.
1.1.
2015
Pekkarinen, PT; Heikkilä, N; Kisand, K; Peterson, P; Botto, M; Daha, MR; Drouet, C; Isaac, L; Helminen, M; Haahtela, T; Meri, S; Jarva, H; Arstila, TP. (2015). Dysregulation of adaptive immune responses in complement C3-deficient patients. European Journal of Immunology, 45 (3), 915−921.10.1002/eji.201444948.
1.1.
2015
Haljasorg, Uku; Bichele, Rudolf; Saare, Mario; Guha, Mithu; Maslovskaja, Julia; Kõnd, Karin; Remm, Anu; Pihlap, Maire; Tomson, Laura; Kisand, Kai; Laan, Martti; Peterson, Pärt (2015). A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice. European Journal of Immunology, 45 (12), 3246−3256.10.1002/eji.201545928.
1.1.
2015
Maslovskaja, Julia; Saare, Mario; Liiv, Ingrid; Rebane, Ana; Peterson, Pärt (2015). Extended HSR/CARD domain mediates AIRE binding to DNA. Biochemical and Biophysical Research Communications, 468 (4), 913−920.10.1016/j.bbrc.2015.11.056.
1.1.
2015
Peters, Marjolein J; Joehanes, Roby; Pilling, Luke C; Schurmann, Claudia; Conneely, Karen N; Powell, Joseph; Reinmaa, Eva; Sutphin, George L; Zhernakova, Alexandra; Schramm, Katharina; Wilson, Yana A; Kobes, Sayuko; Tukiainen, Taru; ,; Ramos, Yolande F; Göring, Harald H H; Fornage, Myriam; Liu, Yongmei; Gharib, Sina A; Stranger, Barbara E ... Johnson, Andrew D (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, 8570−8570.10.1038/ncomms9570.
1.1.
2015
Tserel, Liina; Kolde, Raivo; Limbach, Maia; Tretyakov, Konstantin; Kasela, Silva; Kisand, Kai; Saare, Mario; Vilo, Jaak; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2015). Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes. Scientific Reports, 5 (13107), 1−11.10.1038/srep13107.
1.1.
2015
Falorni, Alberto; Bini, Vittorio; Betterle, Corrado; Brozzetti, Annalisa; Castaño, Luis; Fichna, Marta; Kämpe, Olle; Mellgren, Gunnar; Peterson, Pärt; Chen, Shu; Rönnelid, Johan; Seissler, Jochen; Tiberti, Claudio; Uibo, Raivo; Yu, Liping; Lernmark, Åke; Husebye, Eystein (2015). Determination of 21-hydroxylase autoantibodies: inter-laboratory concordance in the Euradrenal International Serum Exchange Program. Clinical Chemistry and Laboratory Medicine, 53 (11), 1761−1770.10.1515/cclm-2014-1106.
6.8.
2015
Peterson, Pärt (2015). Sirt-ainly Aire. Nature immunology, 16 (7), 680−681.10.1038/ni.3195.
1.1.
2014
Kisand, K.; Peterson, P.; Laan, M. (2014). Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients. Frontiers in Immunology, 5 (51), 1−10.10.3389/fimmu.2014.00051.
1.1.
2014
Wolff, AS.; Kärner, J.; Owe, JF.; Oftedal, BE.; Gilhus, NE.; Erichsen, MM.; Kämpe, O.; Meager, A.; Peterson, P.; Kisand, K.; Willcox, N.; Husebye, ES. (2014). Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors. Journal of Immunology, 193 (8), 3880−3890.10.4049/jimmunol.1401068.
1.1.
2014
Laakso, S.M.; Kekäläinen, E.; Heikkilä, N.; Mannerström, H.; Kisand, K.; Peterson, P.; Ranki, A.; Arstila, T.P. (2014). In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy provides evidence in support of an IL-22 defect. Autoimmunity, 47 (8), 556−562.10.3109/08916934.2014.929666.
1.1.
2014
Zucchelli, Chiara; Tamburri, Simone; Quilici, Giacomo; Palagano, Eleanora; Berardi, Andrea; Saare, Mario; Peterson, Pärt; Bachi, Angela; Musco, Giovanna (2014). Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1. FEBS Journal, 281 (1), 216−231.10.1111/febs.12588.
1.1.
2014
Tserel, Liina; Limbach, Maia; Saare, Mario; Kisand, Kai; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2014). CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing. Immunity and Ageing, 11 (1), Article Number: 1 (1-5).
1.1.
2014
Wolff, Anette S B; Kärner, Jaanika; Owe, Jone F; Oftedal, Bergithe E V; Gilhus, Nils Erik; Erichsen, Martina M; Kämpe, Olle; Meager, Anthony; Peterson, Pärt; Kisand, Kai; Willcox, Nick; Husebye, Eystein S (2014). Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors. Journal of immunology (Baltimore, Md. : 1950), 193 (8), 3880−3890.10.4049/jimmunol.1401068.
1.1.
2013
Kuparinen, Taru; Marttila, Saara; Jylhävä, Juulia; Tserel, Liina; Peterson, Pärt; Jylhä, Marja; Hervonen, Antti; Hurme, Mikko (2013). Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: A transcriptomic analysis. Experimental Gerontology, 48 (3), 305−312.10.1016/j.exger.2012.12.010.
1.1.
2013
Wolff, A. S.;Sarkadi, A. K.;Marodi, L.;Karner, J.;Orlova, E.;Oftedal, B. E.;Kisand, K.;Olah, E.;Meloni, A.;Myhre, A. G.;Husebye, E. S.;Motaghedi, R.;Perheentupa, J.;Peterson, P.;Willcox, N.; Meager, A. (2013). Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type I features in early childhood. Journal of Clinical Immunology, 33 (8), 1341−1348.10.1007/s10875-013-9938-6.
1.1.
2013
Kisand, K; Peterson, P. (2013). Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis. Current Opinion in Pediatrics, 25 (6), 715−721.10.1097/MOP.0000000000000028.
1.1.
2013
Rice, G. I.; Forte, G. M.; Szynkiewicz, M.; Chase, D. S.; Aeby, A.; Abdel-Hamid, M. S.; Ackroyd, S.; Allcock, R.; Bailey, K. M.; Balottin, U.; Barnerias, C.; Bernard, G.; Bodemer, C.; Botella, M. P.; Cereda, C.; Chandler, K. E.; Dabydeen, L.; Dale, R. C.; De Laet, C.; De Goede, C. G. ... Crow, Y. J. (2013). Assessment of interferon-related biomarkers in Aicardi-Goutieres syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. The Lancet Neurology, 12 (12), 1159−1169.10.1016/S1474-4422(13)70258-8.
1.1.
2013
Laan, Martti; Peterson, Pärt (2013). The Many Faces of Aire in Central Tolerance. Frontiers in Immunology, 4, 326.
1.1.
2013
Peterson, Pärt; Laan, Martti (2013). Bipotency of thymic epithelial progenitors comes in sequence. European Journal of Immunology, 43 (3), 580−583.10.1002/eji.201343323.
1.1.
2013
Marttila, Saara; Jylhävä, Juulia; Nevalainen, Tapio; Nykter, Matti; Jylhä, Marja; Hervonen, Antti; Tserel, Liina; Peterson, Pärt; Hurme, Mikko (2013). Transcriptional Analysis Reveals Gender-Specific Changes in the Aging of the Human Immune System. PLoS ONE, 8 (6), e66229.10.1371/journal.pone.0066229.
1.1.
2013
Kärner, J.; Meager, A.; Laan, M.; Maslovskaja, J.; Pihlap, M.; Remm, A.; Juronen, E.; Wolff, A. S. B.; Husebye, E. S.; Podkrajšek, K. T.; Bratanic, N.; Battelino, T.; Willcox, N.; Peterson, P.; Kisand, K. (2013). Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice. Clinical and Experimental Immunology, 171 (3), 263−272.10.1111/cei.12024.
1.1.
2012
Gaetani, Massimiliano; Matafora, Vittoria; Saare, Mario; Spiliotopoulos, Dimitros; Mollica, Luca; Quilici, Giacoma; Chignola, Francesca; Mannella, Valeria; Zucchelli, Chiara; Peterson, Pärt; Bachi, Angela; Musco, Giovanna (2012). AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome. Nucleic Acids Research, 40 (22), 11756−11768.10.1093/nar/gks933.
1.1.
2012
Liiv, Ingrid; Haljasorg, Uku; Kisand, Kai; Maslovskaja, Julia; Laan, Martti; Peterson, Pärt (2012). AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH. Biochemical and Biophysical Research Communications, 423 (1), 32−37.10.1016/j.bbrc.2012.05.057.
1.1.
2012
Saare, M.; Rebane, A.; Rajashekar, B.; Vilo, J., Peterson, P. (2012). Autoimmune regulator is acetylated by transcription coactivator CBP/p300. Experimental and Cellular Research, 318 (14), 1767−78.
1.1.
2012
Wang, Xiaoping; Laan, Martti; Bichele, Rudolf; Kai, Kisand; Scott, Hamish; Peterson, Pärt. (2012). Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Frontiers in Immunology, 1−16.10.3389/fimmu.2012.00019.
1.1.
2011
Kont, V.; Murumägi, A.; Tykocinski, L.O.; Kinkel, S.A.; Webster, K.E.; Kisand, K.; Tserel, L.; Pihlap, M.; Ströbel, P.; Scott, H.S.; Marx, A.; Kyewski, B.; Peterson, P. (2011). DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues. Molecular Immunology, 49 (3), 518−526.10.1016/j.molimm.2011.09.022.
1.1.
2011
Kisand, Kai; Peterson, Pärt (2011). Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome. Annals of New York Academy of Sciences, 1246 (1), 77−91.10.1111/j.1749-6632.2011.06308.x.
1.1.
2011
Morrot, Alexandre; Terra-Granado, Eugênia; Pérez, Ana Rosa; Silva-Barbosa, Suse Dayse; Milićević, Novica; Farias-de-Oliveira, Désio Aurélio; Berbert, Luiz Ricardo, Meis, Juliana De; Takiya, Christina Maeda; Beloscar, Juan; Wang, Xiaoping; Kont, Vivian; Peterson, Pärt; Bottasso, Oscar; Savino, Wilson (2011). Chagasic Thymic Atrophy Does Not Affect Negative Selection but Results in the Export of Activated CD4(+)CD8(+) T Cells in Severe Forms of Human Disease. PLoS Neglected Tropical Diseases, 5 (8), e1268−e1268.10.1371/journal.pntd.0001268.
1.1.
2011
Milićević, N.M.; Miljković, M.D.; Milićević, Z.; Labudović-Borović, M.; Wang, X.; Laan, M.; Peterson, P.; Randall, T.D.; Westermann, J. (2011). Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus. Histochemistry and Cell Biology, 135 (6), 593−601.
1.1.
2011
Kisand, Kai; Lilic, Desa; Casanova, Jean-Laurent; Peterson, Pärt; Meager, Anthony; Willcox, Nick (2011). Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications. European Journal of Immunology, 41 (6), 1517−1527.10.1002/eji.201041253.
1.1.
2011
Tserel, L.; Runnel, T.; Kisand, K.; Pihlap, M.; Bakhoff, L.; Kolde, R.; Peterson, H.; Vilo, J.; Peterson, P.; Rebane, A. (2011). MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4. Journal of Biological Chemistry, 286 (30), 26487−26495.10.1074/jbc.M110.213561.
1.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tõnis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics, 11, 642.10.1186/1471-2164-11-642.
1.1.
2010
Colomé, N.; Collado, J.; Bech-Serra, J.J.; Liiv, I.; Antón, L.C.; Peterson, P.; Canals, F.; Jaraquemada, D.; Alvarez, I. (2010). Increased apoptosis after autoimmune regulator expression in epithelial cells revealed by a combined quantitative proteomics approach. Journal of Proteome Research, 9 (5), 2600−2609.
1.1.
2010
Kyewski, B.; Peterson, P. (2010). Aire, master of many trades. Cell, 140 (1), 24−26.10.1016/j.cell.2009.12.036.
1.1.
2010
Kisand, K.; Bøe Wolff, A.S.; Podkrajsek, K.T.; Tserel, L.; Link, M.; Kisand, K.V.; Ersvaer, E.; Perheentupa, J.; Erichsen, M.M.; Bratanic, N.; Meloni, A.; Cetani, F.; Perniola, R.; Ergun-Longmire, B.; Maclaren, N.; Krohn, K.J.; Pura, M.; Schalke, B.; Ströbel, P., Leite, M.I.; Battelino, T. ... Meager, A. (2010). Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. Journal of Experimental Medicine, 207 (2), 299−308.10.1084/jem.20091669.
1.1.
2010
Poliani PL, Kisand K, Marrella V, Ravanini M, Notarangelo LD, Villa A, Peterson P, Facchetti F (2010). Human Peripheral Lymphoid Tissues Contain Autoimmune Regulator-Expressing Dendritic Cells. American Journal of Pathology, 176 (3), 1104−1112.10.2353/ajpath.2010.090956.
1.1.
2010
Milićević, Ž.; Milićević, N.M.; Laan, M.; Peterson, P.; Kisand, K.; Scott, H.S.; Westermann, J. (2010). Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)-deficient mice. Immunology and Cell Biology, 88, 50−56.10.1038/icb.2009.55.
5.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tonis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Gene Expression and Epigenetic Changes in Differentiation of Human Macrophages and Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 526−526.
5.1.
2010
Rebane, Ana; Tserel, Liina; Kisand, Kai; Backhoff, Lairi; Runnel, Toomas; Kolde, Raivo; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Balanced Expression of miRNA-S Secures Differentiation and Maturation of Human Blood Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 512−513.
1.1.
2009
Holländer, G.A.; Peterson, P. (2009). Learning to be tolerant: how T cells keep out of trouble. Journal of Internal Medicine, 265 (5), 541−546.
1.1.
2009
Laan, M.; Kisand, K.; Kont, V.; Möll, K.; Tserel, L.; Scott, H.S.; Peterson, P. (2009). Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. Journal of Immunology, 183 (12), 7682−7691.10.4049/jimmunol.0804133.
1.1.
2009
Milićević, N.M.; Milićević, Z.; Miljković, M.D.; Labudović-Borović, M.; Laan, M.; Peterson, P.; Kisand, K.; Scott, H.S.; Qu, N.; Westermann, J. (2009). Metallophilic macrophages are fully developed in the thymus of autoimmune regulator (Aire)-deficient mice. Histochemistry and Cell Biology, 131 (5), 643−649.
1.1.
2009
Chignola, F.; Gaetani, M.; Rebane, A.; Org, T.; Mollica, L.; Zucchelli, C.; Spitaleri, A.; Mannella, V.; Peterson, P.; Musco, G. (2009). The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Research, 37 (9), 2951−2961.
1.1.
2009
Hubert, FX.; Kinkel, SA.; Crewther, PE.; Cannon, PZ.; Webster, KE.; Link, M.; Uibo, R.; O'Bryan, MK.; Meager, A.; Forehan, SP.; Smyth, GK.; Mittaz, L.; Antonarakis, SE.; Peterson, P.; Heath, WR.; Scott, HS. (2009). Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. Journal of Immunology, 182 (6), 3902−3918.
1.1.
2009
Hansenne, I.; Louis, C.; Martens, H.; Dorban, G.; Charlet-Renard, C.; Peterson, P.; Geenen, V. (2009). Aire and Foxp3 expression in a particular microenvironment for T cell differentiation. Neuroimmunomodulation, 16 (1), 35−44.
1.1.
2008
Ferguson, B.J.; Alexander, C.E.; Rossi, S.W.; Liiv, I.; Rebane, A.; Worth, C.L.; Wong, J.; Laan, M.; Peterson, P.; Jenkinson, E.J.; Anderson, G.; Scott, H.S.; Cooke, A.; Rich, T. (2008). AIRE's card revealed; A new structure for central tolerance provokes transcriptional plasticity. Journal of Biological Chemistry, 283 (3), 1723−1731.10.1074/jbc.M707211200.
1.1.
2008
Musco, G.; Peterson, P. (2008). PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics, 3 (6), 310−314.
1.1.
2008
Peterson, P.; Org, T.; Rebane, A. (2008). Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nature Reviews Immunology, 8 (12), 948−957.10.1038/nri2450.
1.1.
2008
Ströbel, P.; Chuang, W.Y.; Chuvpilo, S.; Zettl, A.; Katzenberger, T.; Kalbacher, H.; Rieckmann, P.; Nix, W.; Schalke, B.; Gold, R.; Müller-Hermelink, H.K.; Peterson, P.; Marx, A. (2008). Common cellular and diverse genetic basis of thymoma-associated myasthenia gravis: role of MHC class II and AIRE genes and genetic polymorphisms. Annals of New York Academy of Sciences, 1132, 143−156.10.1196/annals.1405.018.
1.1.
2008
Meager, A.; Peterson, P.; Willcox, N. (2008). Hypothetical review: thymic aberrations and type-I interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes. Clinical and Experimental Immunology, 154 (1), 141−151.10.1111/j.1365-2249.2008.03739.x.
1.1.
2008
Kisand, K.; Link, M.; Wolff, A.S. B.; Meager, A.; Tserel, L.; Org, T.; Murumägi, A.; Uibo, R.; Willcox, N.; Podkrajšek Trebušak, K.; Battelino, T.; Lobell, A.; Kämpe, O.; Perheentupa, J.; Krohn, K.; Scott, H.S.; Husebye, E.S.; Peterson, P. (2008). Interferon autoantibodies associated with AIRE-deficiency decrease the expression of IFN-stimulated genes. Blood, 112 (7), 2657−2666.
1.1.
2008
Ferguson, B.J.; Cooke, A.; Peterson, P.; Rich, T. (2008). Death in the AIRE. Trends in Immunology, 29 (7), 306−312.10.1016/j.it.2008.03.004.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta - Molecular Cell Research, 1783 (1), 74−83.10.1016/j.bbamcr.2007.09.003.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376.10.1038/embor.2008.11.
1.1.
2008
Reimand, K.; Perheentupa, J.; Link, M.; Krohn, K.; Peterson, P.; Uibo, R. (2008). Testis-expressed protein TSGA10 – an autoantigen in Autoimmune Polyendocrine Syndrome Type I. International Immunology, 20 (1), 39−44.10.1093/intimm/dxm118.
1.1.
2008
Kont, V.; Laan, M.; Kisand, K.; Merits, A.; Scott, H.S.; Peterson, P. (2008). Modulation of Aire regulates the expression of tissue-restriced antigens. Molecular Immunology, 45 (1), 25−33.
1.1.
2007
Gombos, Z.; Hermann, R.; Kiviniemi, M.; Nejentsev, S.; Reimand, K.; Fadeyev, V.; Peterson, P.; Uibo, R.; Ilonen, J. (2007). Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populations. European Journal of Endocrinology, 157 (6), 757−761.10.1530/EJE-07-0290.
1.1.
2007
Strobel, P.; Murumagi, A.; Klein, R.; Luster, M.; Lahti, M.; Krohn, K.; Schalke, B.; Nix, W.; Gold, R.; Rieckmann, P.; Toyka, K.; Burek, C.; Rosenwald, A.; Muller-Hermelink, H.K.; Pujoll-Borrell, R.; Meager, A.; Willcox, N.; Peterson, P.; Marx, A. (2007). Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicitautoimmune polyendocrinopathy syndrome type 1 (APS-1). The Journal of Pathology, 211 (5), 563−571.
1.2.
2007
O'Dwyer, D.T.; McElduff, P.; Peterson, P.; Perheentupa, J.; Crock, P.A. (2007). Pituitary autoantibodies in autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy (APECED). Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma, 78, 248−254.
1.3.
2007
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U.; Mollica, L.; Musco, G.; Peterson, P. (2007). Autoimmuunsuse regulaator (AIRE) valgu PHD tsink sõrm seondub geeniekspressiooni aktiviseerimiseks mittemetüleeritud histoon H3K4-ga. Eesti Arst, 9, 685.
3.1.
2007
Kämpe, O.; Peterson, P. (2007). Autoimmune Polyglandular Syndrome Type 1. In: Weetman, A. P. (_EditorsAbbr). Autoimmune Diseases in Endocrinology (303−410).. Humana Press.
5.1.
2007
Ilonen, J.; Gombos, Z.; Hermann, R.; Kiviniemi, M.; Nejentsev, S.; Reimand, K.; Fadeyev, V.; Peterson, P.; Uibo, R. (2007). Type 1 diabetes and Addison's disease are associated with different HLA-DRB1*0404-DQB1*0302 haplotypes. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 65: 37th Annual Meeting of the Scandinavian-Society-for-Immunology; Turku, FINLAND, JUN 06-09, 2007. BLACKWELL PUBLISHING, 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND: Blackwell Publishing, 601−602. (6).
1.1.
2006
Zhang, B., Wang, Z., Ding, J., Peterson, P., Gunning, W.T., Ding, H.F. (2006). NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells. Journal of Biological Chemistry, 281 (50), 38617−38624.
1.1.
2006
Viiri, K.M.; Korkeamaki, H.; Kukkonen, M.K.; Nieminen, L.K.; Lindfors, K.; Peterson, P.; Maki, M.; Kainulainen, H.; Lohi, O. (2006). SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucleic Acids Research, 34 (11), 3288−3298.
1.1.
2006
Meager, A.; Visvalingam, K.; Peterson, P.; Moll, K.; Murumagi, A.; Krohn, K.; Eskelin, P.; Perheentupa, J.; Husebye, E.; Kadota, Y.; Willcox, N. (2006). Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1. PLOS Medicine, 3 (7), 1151−1164.
1.1.
2006
Murumagi, A.; Silvennoinen, O.; Peterson, P. (2006). Ets transcription factors regulate AIRE gene promoter. Biochemical and Biophysical Research Communications, 348 (2), 768−774.
3.1.
2006
Peterson, P.; Uibo, R.; Kämpe, O. (2006). Polyendocrine syndromes. In: Rose, N.R.; Mackay, I.R. (_EditorsAbbr). The Autoimmune Diseases, 4th Edition (515−526).. Academic Press.
1.1.
2005
Pitkanen, J.; Rebane, A.; Rowell, J.; Murumagi, A.; Strobel, P.; Moll, K.; Saare, M.; Heikkila, J.; Doucas, V.; Marx, A.; Peterson, P. (2005). Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochemical and Biophysical Research Communications, 333 (3), 944−953.10.1016/j.bbrc.2005.05.187.
1.1.
2005
Tawfik, S.; Azim, M.A.; Peterson, P.; Donaldson, M.D. (2005). Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy presenting with severe keratopathy in an Egyptian patient with a homozygous R139X mutation. Hormone Research, 64 (2), 96−99.
1.1.
2005
Karenko, L.; Hahtola, S.; Paivinen, S.; Karhu, R.; Syrja, S.; Kahkonen, M.; Nedoszytko, B.; Kytola, S.; Zhou, Y.; Blazevic, V.; Pesonen, M.; Nevala, H.; Nupponen, N.; Sihto, H.; Krebs, I.; Poustka, A.; Roszkiewicz, J.; Saksela, K.; Peterson, P.; Visakorpi, T. ... Ranki, A. (2005). Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer research, 65 (18), 8101−8110.
1.1.
2005
Tuomela, M.; Malm, M.; Wallen, M.; Stanescu, I; Krohn, K.; Peterson, P. (2005). Biodistribution and general safety of a naked DNA plasmid, GTU®-MULTIHIV, in a rat, using a quantitative PCR method. Vaccine, 23 (7), 890−896.
1.1.
2005
Peterson, P.; Peltonen, L. (2005). Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: New views on molecular basis of autoimmunity. Journal of Autoimmunity, 25, 49−55.
1.1.
2005
Webster, KE.; O'Bryan, MK.; Fletcher, S.; Crewther, PE.; Aapola, U.; Craig, J.; Harrison, DK.; Aung, H.; Phutikanit, N.; Lyle, R.; Meachem, SJ.; Antonarakis, SE.; de Krester, DM.; Hedger, MP.; Peterson, P.; Carroll, BJ.; Scott, HS. (2005). Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America, 102 (11), 4068−4073.
1.1.
2005
Pitkanen, J.; Rebane, A.; Rowell, J.; Murumagi, A.; Strobel, P.; Moll, K.; Heikkila, J.; Doucas, V.; Marx, A.; Peterson, P. (2005). Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochemical and Biophysical Research Communications, 333 (3), 944−953.
5.2.
2005
Reimand, K.; Link, M.; Peterson, P.; Uibo, R. (2005). Tsga10 – tõenäone elundispetsiifiline autoantigeen APS I sündroomi korral. Eesti Arst, 84 (9), 678−679.
1.1.
2004
Stjernberg-Salmela, S.; Pettersson, T.; Karenko, L.; Blazevic, V.; Nevala, H.; Pitkänen, S.; Peterson, P.; Ranki, A. (2004). A novel tumour necrosis factor receptor mutation in a Finnish family with periodic fever syndrome. Scandinavian Journal of Rheumatology, 33 (3), 140−144.
1.1.
2004
Ströbel, P.; Rosenwald, A.; Baiersdorf, N.; Kerkau, T.; Elert, O.; Murumägi, A.; Sillanpää, N.; Peterson, P.; Hummel, V.; Rieckmann, P.; Burek, C.; Schalke, B.; Nix, W.; Kiefer, R.; Müller-Hermelink, H. K.; Marx, A. (2004). Selective loss of regulatory T cells in thymomas. Annals of Neurology, 56 (6), 901−904.
1.1.
2004
Sillanpää, N.; Magureanu, C. M.; Murumägi, A.; Reinikainen, A.; Manninen, A.; Heino, M.; Ranki, A.; Saksela, K.; Krohn, K.; Lahesmaa, R.; Peterson, P. (2004). Autoimmune regulator induced changes in the gene expression profile of monocyte-dendritic cell-lineage. Molecular Immunology, 41 (12), 1185−1198.10.1016/j.molimm.2004.06.004.
1.1.
2004
Akiyoshi, H.; Hatakeyama, S.; Pitkänen, J.; Mouri, Y.; Doucas, V.; Kudoh, J.; Tsurugaya, K.; Uchida, D.; Matsushima, A.; Oshikawa, K.; Nakayama, K. I.; Shimizu, N.; Peterson, P.; Matsumoto, M. (2004). Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. Journal of Biological Chemistry, 279 (32), 33984−33991.
1.1.
2004
Peterson, P.; Pitkanen, J.; Sillanpaa, N.; Krohn, K. (2004). Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity. Clinical and Experimental Immunology, 135 (3), 348−357.
1.1.
2004
Aapola, U.; Maenpaa, K.; Kaipia, A.; Peterson, P. (2004). Epigenetic modifications affect Dnmt3L expression. Biochemical Journal, 380, 705−713.
1.2.
2004
Krohn, K.; Peterson, P. (2004). The central role of AIRE in thymic induction of tolerance to self antigens. Current Opinion in Endocrinology and Diabetes, 11 (1), 26−30.
3.2.
2004
Peterson, P. (2004). Autoimmuunsus: rikutud tasakaal. Tasakaalu teooria (86−88).. Tartu: Sulemees.
1.1.
2003
Chin, R. K.; Lo, J. C.; Kim, O.; Blink, S. E.; Christiansen, P. A.; Peterson, P.; Wang, Y.; Ware, C.; Fu, Y. X. (2003). Lymphotoxin pathway directs thymic Aire expression. Nature immunology, 4 (11), 1121−1127.
1.1.
2003
Pitkänen, J.; Peterson, P. (2003). Autoimmune regulator: from loss of function to autoimmunity. Genes and Immunity, 4 (1), 12−21.
1.1.
2003
Murumagi, A.; Vahamurto, P.; Peterson, P. (2003). Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. Journal of Biological Chemistry, 278 (22), 19784−19790.
6.3.
2003
Peterson, P. (2003). Autoimmuunhaigused: omad muutuvad võõrasteks. Eesti Loodus, 9, 38−40.
1.1.
2002
Nevala, H.; Karenko, L.; Stjernberg, S.; Raatikainen, M.; Suomalainen, H.; Lagerstedt, A.; Rauta, J.; McDermott, M. F.; Peterson, P.; Pettersson, T.; Ranki, A. (2002). A Novel Mutation in the Third Extracellular Domain of the Tumor Necrosis Factor Receptor 1 in a Finnish Family With Autosomal-Dominant Recurrent Fever. Arthritis and Rheumatism, 46 (4), 1061−1066.10.1002/art.10224.
1.1.
2002
Liiv, I.; Teesalu, K.; Peterson, P.; Clemente, MG.; Perheentupa, J.; Uibo, R. (2002). Epitope mapping of cytochrome P450 cholesterol side-chain cleavage enzyme by sera from patients with autoimmune polyglandular syndrome type 1. European Journal of Endocrinology, 146 (1), 113−119.
1.1.
2002
Aapola, U.; Liiv, I.; Peterson, P. (2002). Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. Nucleic Acids Research, 30 (16), 3602−3608.
5.1.
2002
Nikopensius, T.; Peterson, P.; Kurg, A.; Krohn, KJE.; Saha, M.; Ilonen, J.; Knip, M.; Metspalu, A. (2002). AIRE gene polymorphisms in Finnish patients with type 1 diabetes. European Journal of Human Genetics, 10, 164−164.
1.1.
2001
Tähtinen, M.; Strengell, M.; Collings, A.; Pitkänen, J.; Hakkarainen, K.; Ustav, M.; Wahren, B.; Peterson, P.; Kohleisen, B.; Ranki, A.; Krohn, K. (2001). DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating bovine papilloma virus based pBN-vector. Vaccine, 19, 2039−2047.
1.1.
2001
Aapola, U.; Lyle, R.; Krohn, K.; Antonarakis, S. E.; Peterson, P. (2001). Isolation and Tissue Distribution of Mouse Dnmt3l gene. Cytogenetics and Cell Genetics, 92, 122−126.
1.1.
2001
Heino, H.; Peterson, P.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E.; Scott, H. S.; Krohn, K. (2001). APECED mutations in the Autoimmune Regulator (AIRE) gene. Human Mutation, 18 (3), 205−211.
1.1.
2001
Cihakova, D.; Trebusak, Heino, M.; Fadeyev, V.; Tiulpakov, A.; Battelino, T.; Tar, A.; Halasz, Z.; Blumel, P.; Tawfik, S.; Krohn, K.; Lebl, J.; Peterson, P. (2001). Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED. Human Mutation, 18 (3), 225−232.
1.1.
2001
Pitkänen, J.; Vähämurto, P.; Krohn, K.; Peterson, P. (2001). Subcellular localization of the autoimmune regulator protein: characterization of nuclear targeting and transcriptional activation domain. Journal of Biological Chemistry, 276, 19597−19602.
1.2.
2001
Lebl, J.; Cihakova, D.; Trebusak, K.; Heino, M.; Battelino, T.; Halasz, Z.; Tar, A.; Blumel, P.; Fadejev, V.; Tyulpakov, A.; Krohn, K.; Peterson, P. (2001). Autoimmune Polyglandular Syndrome-1 (APS-1; APECED) in Central and Eastern Europe: Novel Mutations of AIRE Gene and P450 Cytochrome Autoantibodies. Pediatric Research, 49, 122−122.
1.1.
2000
Aapola, U.; Shibuya, K.; Scott, H. S.; Ollila, O.; Vihinen, M.; Heino, M.; Shintani, A.; Kawasaki, K.; Minoshima, S.; Krohn, K.; Antonarakis, S. E.; Shimizu, N.; Kudoh, J.; Peterson, P. (2000). Isolation and initial characterization of a novel zinc finger gene, DNMT3L on 21q22.3, related to cytosine-5-methyltransferase 3 gene family. Genomics, 65, 293−298.
1.1.
2000
Pitkänen, J.; Doucas, V.; Sternsdor, T.; Nakajima, T.; Aratani, S.; Jensen, K.; Will, H.; Vähämurto, P.; Ollila, J.; Vihinen, M.; Scott, H. S.; Antonarakis, S. E.; Kudoh, J.; Shimizu, N.; Krohn, K.; Peterson, P. (2000). The autoimmune regulator protein has transcriptional transactivating properties and interacts with common co-activator CBP. Journal of Biological Chemistry, 275, 16802−16809.
1.1.
2000
Heino, M.; Peterson, P.; Sillanpää, N.; Guérin, S.; Wu, L.; Naquet, P.; Anderson, G.; Scott, H. S.; Antonarakis, S. E.; Jenkinson, E. J.; Krohn, K. (2000). RNA and protein expression of the murine Autoimmune Regulator gene (Aire) in normal, RelB deficient and in NOD mouse. European Journal of Immunology, 30, 1884−1893.
1.1.
2000
Peterson, P.; Uibo, R.; Krohn, KJE. (2000). Adrenal autoimmunity: Results and developments. Trends in endocrinology and metabolism: TEM, 11 (7), 285−290.
1.1.
2000
Reimand, K.; Peterson, P.; Hyoty, H.; Uibo, R.; Cooke, I.; Weetman, AP.; Krohn, KJE. (2000). 3 beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure. Journal of Clinical Endocrinology and Metabolism, 85 (6), 2324−2326.
1.1.
1999
Collings, A.; Pitkanen, J.; Strengell, M.; Tahtinen, M.; Pitkanen, J.; Lagerstedt, A.; Hakkarainen, K.; Ovod, V.; Sutter, G.; Ustav, M.; Ustav, E.; Mannik, A; Ranki, A; Peterson, P.; Krohn, K. (1999). Humoral and cellular response to HIV-1 Nef in mice DNA-immunized with non-replicating and self-replicating expression vectors. Vaccine, 18, 460−467.
1.1.
1999
Heino, M.; Scott, H. S.; Chen, Q.; Peterson, P.; Mäenpää, U.; Papasavvas, M. P.; Mittaz, L.; Barras, C.; Rossier, C.; Stratakis, A.; Chrousos, G.; Nagamine, K.; Kudoh, J.; Shimizu, N.; Maclaren, N.; Antonarakis, S. E.; Krohn, K. (1999). Mutation analyses of Northern American APS-1 patients. Human Mutation, 13 (1), 69−74.
1.1.
1999
Heino, M.; Peterson, P.; Kudoh, J.; Nagamine, K.; Lagerstedt, A.; Ovod, V.; Ranki, A.; Rantala, I.; Nieminen, M.; Tuukkanen, J.; Scott, H.S.; Antonarakis, S.E.; Shimizu, N.; Krohn, K. (1999). Autoimmune regulator (AIRE) is expressed in the cells regulating immune tolerance in thymus medulla. Biochemical and Biophysical Research Communications, 257 (3), 821−825.
1.1.
1999
Mittaz, L.; Rossier, C.; Heino, M.; Peterson, P.; Krohn, K. J. E.; Gos, A.; Morris, M. A.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E.; Scott, H. S. (1999). Isolation and characterization of the mouse Aire gene. Biochemical and Biophysical Research Communications, 255 (2), 483−490.
1.1.
1999
Seissler, J.; Schott, M.; Steinbrenner, H.; Peterson, P.; Scherbaum, W. A. (1999). Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison’s disease and autoimune polyendocrine syndrome type II. Experimental and Clinical Endocrinology of Diabetes, 107, 208−213.
1.1.
1999
Beltran-Valero, D.; Peterson, P.; Luopajärvi, K.; Matintalo, P.; Alho, A.; Konttinen, Y.; Krohn, K.; Rodriguez, S.; Ranki, A. (1999). Mutational analysis of the HGO gene in Finnish alkaptonuria patients. American Journal of Medical Genetics, 36 (12), 922−923.
1.3.
1999
Fadejev, V.V.; Peterson, P.; Ovod, V.; Melnitchenko, G.A.; Dedov, I.I.; Krohn, K. (1999). Antibodies to steroidogenic enzymes 21-hydroxylase, 17a-hydroxylase and side-chain cleavage enzyme in etiological diagnostics of Addison's disease and autoimmune polyglandular syndromes. Problemy endokrinologii (Moskva), 45/6, 24−28.
6.3.
1999
Peterson, P. (1999). Tagasivaade teadmatusse ehk kust me eestlased tuleme? Horisont, 33 (1), 22−25.
1.1.
1998
Scott, H. S.; Kyriakou, D.; Peterson, P.; Heino, H.; Tähtinen, M.; Krohn, K.; Chen, H.; Rossier, C.; Lalioti, M. D.; Antonarakis, S. E. (1998). Characterization of a novel gene, C21orf2, an human chromosome 21q22.3 and its exclusion as the APECED gene by mutation analysis. Genomics, 47, 64−70.
1.1.
1998
Scott, H.S.; Heino, M.; Peterson, P.; Mittaz, L.; Lalioti, M.D.; Betterle, C.; Cohen, A.; Seri, M.; Lerone, M.; Romeo, G.; Collin, P.; Salo, M.; Metcalfe, R.; Weetman, A.; Papasavvas, M.P.; Rossier, C.; Nagamine, K.; Kudoh, J.; Shimizu, N.; Krohn, K.J.E. ... Antonarakis, S.E. (1998). Common mutations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients of different origins. Molecular Endocrinology, 12 (8), 1112−1119.
1.1.
1998
Peterson, P.; Nagamine, K.; Scott, H. S.; Heino, M.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E.; Krohn, K. (1998). APECED: a monogenic autoimmune disease providing new clues to self tolerance. Trends in Immunology, 9, 19, 384−386.
1.1.
1998
Rosatelli, M.; Meloni, A.; Devoto, M.; Cao, A.; Scott, H. S.; Peterson, P.; Heino, M.; Krohn, K.; Nagamine, K.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E. (1998). A common mutation in Sardinian autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy patients. Human Genetics, 103 (4), 428−434.
1.1.
1998
Kemp, EH.; Ajjan, RA.; Husebye, ES.; Peterson, P.; Uibo, R.; Imrie, H.; Pearce, SHS.; Watson, PF.; Weetman, AP. (1998). A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients. Clinical Endocrinology, 49 (5), 609−613.
1.3.
1998
Peterson, P.; Heino, M.; Krohn, K. (1998). Immunological and genetic background of APECED syndrome. Duodecim, 114 (15), 1458−1464.
3.1.
1998
Peterson, P.; Uibo, R.; Krohn, K.; Weetman, A. (1998). Addison's disease and related polyendocrinopathies. In: Endocrine Autoimmunity and Associated Conditions (163 −182).. Springer-Verlag.
1.1.
1997
Peterson, P.; Salmi, H.; Hyöty, H.; Miettinen, A.; Ilonen, J.; Reijonen, H.; Åkerblom, H.; Krohn, K. (1997). Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Clinical Immunology and Immunopathology (continued as Clinical Immunology), 82 (1), 37−42.
1.1.
1997
Krohn, K.; Ovod, V.; Vilja, P.; Heino, M.; Scott, H.; Kyriakou, D. S.; Antonarakis, S. E.; Jacobs, H. T.; Isola, I.; Peterson, P. (1997). Immunochemical characterization of a novel mitochondrially located protein encoded by a nuclear gene within the DFNB8/10 critical region on 21q22.3. Biochemical and Biophysical Research Communications, 238 (3), 806−810.
1.1.
1997
Nagamine, K.; Peterson, P.; Scott, H. S.; Kudoh, J.; Minoshima, S.; Heino, M.; Krohn, K. J. E.; Lalioti, M. D.; Mullis, P. E.; Antonarakis, S. E.; Kawasaki, K.; Asakawa, S.; Ito, F.; Shimizu, N. (1997). Positional cloning of the APECED gene. Nature Genetics, 17, 393−397.
1.1.
1997
Uibo, R.; Uibo, O.; Reimand, K.; Peterson, P.; Krohn, K. (1997). Characterization by molecular cloning an antigen reactive with antireticulin antibodies. B Lymphocytes and Autoimmunity, 815, 509−511.
1.1.
1997
Peterson, P., Uibo, R., Peranen, J., Krohn, K. (1997). Immunoprecipitation of steroidogenic enzyme autoantigens with autoimmune polyglandular syndrome type I (APS I) sera; further evidence for independent humoral immunity to P450c17 and P450c21. Clinical and Experimental Immunology, 107 (2), 335−340.
1.3.
1997
Vaha-Kreula, T., Luopajarvi, K., Peterson, P., Kuokkanen, K., Ranki, A. (1997). Mystery of the blue man: alkaptonuria. Duodecim, 113 (21), 2175−2179.
3.1.
1997
Uibo, R.; Uibo, O.; Peterson, P.; Reimand, K.; Krohn, K. (1997). Molecular cloning of antigen, reactive with reticulin antibodies. In: Slikker, W.; Trembly, B. (_EditorsAbbr). Neuroprotective Agents: Third International Conference (511−513).. New York Academy of Sciences. (Annals of the New York academy of Sciences; 825).
1.1.
1996
Peterson, P.; Perheentupa, J.; Krohn, K. (1996). Detection of candidal antigens in autoimmune polyglandular syndrome type I. Clinical and Diagnostic Laboratory Immunology, 3 (3), 290−294.
2.3.
1996
Peterson, P. (1996). Disease-associated antigens and HLA in autoimmune Addison's disease and polyglandular syndromes. (Doktoritöö). Tampere: University of Tampere.
2.3.
1996
Peterson, P. (1996). Disease-associated antigens and HLA in autoimmune Addison's disease and polyglandular syndromes. (University of Tampere). Tampere: University of Tampere.
1.1.
1995
Peterson, P.; Partanen, J.; Aavik, E.; Salmi, H.; Krohn, K. (1995). Steroid 21-hydroxylase gene polymorphism in Addison's disease patients. Tissue Antigens, 46 (1), 63−67.
1.1.
1994
Ranki, A.; Aavik, E.; Peterson, P.; Schauman, K.; Nurmilaakso, P. (1994). Successful amplification of DNA specific for Finnish Borrelia Burgdorferi-isolates in erythema chronicum migrans but not in circumscribed scleroderma lesions. The Journal of Investigative Dermatology, 102, 339−345.
1.1.
1994
Peterson, P.; Krohn, K. (1994). Mapping of b-cell epitopes on steroid 17-alpha-hydroxylase, an autoantigen in autoimmune polyglandular syndrome type-i. Clinical and Experimental Immunology, 1 (98), 104−109.
1.1.
1994
Partanen, J.; Peterson, P.; Westman, P.; Aranko, S.; Krohn, K. (1994). Major histocompatibility complex class-ii and class-iii in Addisons-disease - MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility. Human Immunology, 41, 135−140.
1.1.
1994
Uibo, R.; Aavik, E.; Peterson, P.; Perheentupa, J.; Arako, S.; Pelkonen, R.; Krohn, K.J.E. (1994). Autoantibodies to cytochrome-p450 enzymes p450scc, p450c17, and p450c21 in autoimmune polyglandular disease type-i and type-ii and in isolated addisons-disease. Journal of Clinical Endocrinology and Metabolism, 78 (2), 323−328.
1.1.
1992
Krohn, K.; Uibo, R.; Aavik, E.; Peterson, P.; Savilahti, K. (1992). Identification by molecular-cloning of an autoantigen associated with addisons-disease as steroid 17-alpha-hydroxylase. Lancet, 339 (8796), 770−773.
6.7.
1992
Peterson, Pärt (1992). Identification of autoantigenic B cell epitopes on human steroid 17[alfa]-hydroxylase, an autoantigen of Addison's disease in type I polyglandural syndrome : the academic research work for attaining a degree of Master of Sciences at University of Tartu. Tartu: University of Tartu.
6.7.
1992
Peterson, P. (1992). Identification of autoantigenic B cell epitopes on human steroid 17[alfa]-hydroxylase, an autoantigen of Addison's disease in type I polyglandural syndrome : the academic research work for attaining a degree of Master of Sciences at University of Tartu. (University of Tartu; University of Tampere). Tartu: University of Tartu.

Tööstusomand

18.04.2019

Pärt Peterson

https://www.etis.ee/CV/Pärt_Peterson/eng
18.04.1966
737 4202
part.peterson@ut.ee
ResearcherID: A-5788-2009

Career

Institution and occupation
01.02.2019–...   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Professor of Molecular Immunology (1,00)
11.01.2016–10.01.2021   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Head of Office
1992-1994, Institute of Biotechnology, University of Tampere
1995-2000, Institute of Medical Technology, University of Tampere
2000-2003 Scientist of Finnish Academy
2003- Extraordinary professor, Medical Faculty, University of Tartu
01.01.2018–31.01.2019   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Research Professor of Molecular Immunology (0,50)
01.01.2016–10.01.2016   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Head of Office
01.01.2016–31.12.2017   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Lead Research Fellow of Molecular Immunology (0,50)
01.01.2016–31.01.2019   
University of Tartu, Faculty of Medicine, Institute of Biomedicine and Translational Medicine, Professor of Molecular Immunology (0,50)
01.11.2014–31.12.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Lead Research Fellow of Molecular Immunology (0,50)
01.11.2014–31.12.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Professor of Molecular Immunology (0,50)
01.09.2013–31.12.2015   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Head of Office
01.09.2013–31.10.2014   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Professor of Molecular Immunology (0,50)
18.06.2013–31.08.2013   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Head of Office
22.05.2013–03.06.2013   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Acting Head of Institute
21.05.2013–31.10.2014   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Lead Research Fellow of Molecular Immunology (0,50)
21.05.2013–31.08.2013   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Professor of Molecular Immunology (0,50)
01.01.2013–20.05.2013   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Lead Research Fellow of Molecular Immunology (0,50)
01.01.2013–20.05.2013   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Professor of Molecular Immunology (0,50)
23.12.2012–20.05.2013   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Head of Institute
01.03.2011–22.12.2012   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Head of Institute
2010–2012   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Head (0,20)
01.04.2009–22.12.2012   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Reseach Professor (1,00)
01.09.2008–31.12.2012   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Professor of Molecular Immunology (1,00)
2008–2012   
Estonian Academy of Sciences, Academy Research Professor (1,00)
01.09.2006–31.08.2008   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Professor extraordinarius (1,00)
01.09.2003–31.08.2006   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Professor extraordinarius (1,00)
 
 
Education
1992–1996   
PhD (molecular immunology) University of Tampere
1991–1992   
MSc, University of Tartu
1984–1991   
Faculty of Biology, University of Tartu, 1991
 
 
R&D related managerial and administrative work
2016−...   
Board member of Estonian Society for Immunology and Allergology (EIAS)
2015−...   
Head of the Board, Institute of Biomedicine and Translational Medicine, University of Tartu
2015−...   
Review Editor, Editorial Board, Frontiers in Immunology journal
2013−...   
Editorial Board Member, European Journal of Immunology
2011−...   
Editorial Board Member, Scandinavian Journal of Immunology
2003−...   
Member of Estonian Society of Human Genetics
2013−2015   
Member of the Evaluation Committee, Estonian Research Council
2009−2012   
Estonian Research Council, member
2007−2015   
Board member of the Institute of Molecular and Cellular Biology, University of Tartu
2004−2009   
Board Member of Estonian Society of Human Genetics
2000−2003   
Member of the Board (Institute of Medical Technology, University of Tampere)
2000−2003   
Member of the evaluation board for evaluation Tampere Graduate School in Biosciences

Qualifications

Academic degrees
Pärt Peterson, Doctor's Degree, 1996, (sup) Kai Krohn, Disease-associated antigens and HLA in autoimmune Addison’s disease and polyglandular syndromes, Tampere Ülikool.
Pärt Peterson, Master's Degree, 1992, (sup) Ain Heinaru; Kai Krohn, Identification of autoantigenic B-cell epitopes on human steroid 17a-hydroxylase, an autoantigen of Addison's disease in type I polyglandular syndrome (Addisoni tõve autoantigeeni, steroid 17-hüdroksülaasi, B-rakuliste epitoopide leidmine), University of Tartu, Faculty of Biology and Geography.
 
 
Honours & awards
2009, Pärt Peterson, National Science Award
 
 
Field of research
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine
 
 
Additional information
MSc
PhD (immunology)
Dotsent (molecular immunology)
University of Tartu, 1992
University of Tampere, 1996
University of Tampere, 1998

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Kaleviste, Epp; Saare, Mario; Leahy, Timothy Ronan; Bondet, Vincent; Duffy, Darragh; Mogensen, Trine; Jørgensen, Sofie E; Nurm, Helke; Ip, Winnie; Davies, E Graham; Sauer, Sascha; Syvänen, Ann-Christine; Milani, Lili; Peterson, Pärt; Kisand, Kai (2019). Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined. European Journal of Immunology.10.1002/eji.201847955 [forthcoming].
1.1.
2018
Rodrigues, Pedro M.; Peterson, Part; Alves, Nuno L. (2018). Setting Up the Perimeter of Tolerance: Insights into mTEC Physiology. Trends in Immunology, 39 (1), 2−5.10.1016/j.it.2017.11.001.
1.1.
2018
Lalić, Ivana M.; Bichele, Rudolf; Repar, Anja; Despotović, Sanja Z; Petričević, Saša; Laan, Martti; Peterson, Pärt; Westermann, Jürgen; Milićević, Živana; Mirkov, Ivana; Milićević, Novica M. (2018). Lipopolysaccharide induces tumor necrosis factor receptor-1 independent relocation of lymphocytes from the red pulp of the mouse spleen. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 216, 125−134.10.1016/j.aanat.2017.12.002.
1.1.
2018
Bichele, R.; Kärner, J.; Truusalu, K.; Smidt, I.; Mändar, R.; Conti, HR.; Gaffen, SL.; Peterson, P.; Laan, M.; Kisand, K. (2018). IL-22 neutralizing autoantibodies impair fungal clearance in murine oropharyngeal candidiasis model. European Journal of Immunology, 48 (3), 464−470.10.1002/eji.201747209.
1.1.
2018
Ossart, Jason; Moreau, Anne; Autrusseau, Elodie; Ménoret, Séverine; Martin, Jérôme C; Besnard, Marine; Ouisse, Laure-Hélène; Tesson, Laurent; Flippe, Léa; Kisand, Kai; Peterson, Pärt; Hubert, François-Xavier; Anegon, Ignacio; Josien, Régis; Guillonneau, Carole (2018). Breakdown of Immune Tolerance in AIRE-Deficient Rats Induces a Severe Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-like Autoimmune Disease. Journal of immunology (Baltimore, Md. : 1950), 201 (3), 874−887.10.4049/jimmunol.1701318.
1.1.
2017
Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, Tasa T, Metspalu A, Milani L, Peterson P. (2017). DNA breaks and chromatin structural changes enhance the transcription of Autoimmune Regulator target genes. Journal of Biological Chemistry, 292 (16), 6542−6554.jbc.M116.764704.
1.1.
2017
Lepik, Kaido; Annilo, Tarmo; Kukuškina, Viktorija; eQTLGen Consortium; Kisand, Kai; Kutalik, Zoltán; Peterson, Pärt; Peterson, Hedi (2017). C-reactive protein upregulates the whole blood expression of CD59 - an integrative analysis. PLoS Computational Biology, 13 (9), e1005766−e1005766.10.1371/journal.pcbi.1005766.
1.1.
2017
Fishman, Dmytro; Kisand, Kai; Hertel, Christina; Rothe, Mike; Remm, Anu; Pihlap, Maire; Adler, Priit; Vilo, Jaak; Peet, Aleksandr; Meloni, Antonella; Podkrajsek, Katarina Trebusak; Battelino, Tadej; Bruserud, Øyvind; Wolff, Anette S B; Husebye, Eystein S; Kluger, Nicolas; Krohn, Kai; Ranki, Annamari; Peterson, Hedi; Hayday, Adrian ... Peterson, Pärt (2017). Autoantibody Repertoire in APECED Patients Targets Two Distinct Subgroups of Proteins. Frontiers in Immunology, 8, 976−976.10.3389/fimmu.2017.00976.
1.1.
2017
Hermann, Helen; Runnel, Toomas; Aab, Alar; Baurecht, Hansjörg; Rodriguez, Elke; Magilnick, Nathaniel; Urgard, Egon; Šahmatova, Liisi; Prans, Ele; Maslovskaja, Julia; Abram, Kristi; Karelson, Maire; Kaldvee, Bret; Reemann, Paula; Haljasorg, Uku; Rückert, Beate; Wawrzyniak, Paulina; Weichenthal, Michael; Mrowietz, Ulrich; Franke, Andre ... (2017). miR-146b probably assists miRNA-146a in the suppression of keratinocyte proliferation and inflammatory responses in psoriasis. The Journal of Investigative Dermatology.10.1016/j.jid.2017.05.012.
1.1.
2017
Šahmatova, Liisi; Sügis, Elena; Šunina, Marina; Hermann, Helen; Prans, Ele; Pihlap, Maire; Abram, Kristi; Rebane, Ana; Peterson, Hedi; Peterson, Pärt; Kingo, Külli; Kisand, Kai (2017). Signs of innate immune activation and premature immunosenescence in psoriasis patients. Scientific Reports, 7 (1), 7553−7553.10.1038/s41598-017-07975-2.
1.1.
2017
Cossarizza, Andrea; Chang, Hyun-Dong; Radbruch, Andreas; Andrä, Immanuel; Annunziato, Francesco; Bacher, Petra; Barnaba, Vincenzo; Battistini, Luca; Bauer, Wolfgang M; Baumgart, Sabine; Becher, Burkhard; Beisker, Wolfgang; Berek, Claudia; Blanco, Alfonso; Borsellino, Giovanna; Boulais, Philip E; Brinkman, Ryan R; Büscher, Martin; Busch, Dirk H; Bushnell, Timothy P ... Zimmermann, Jakob (2017). Guidelines for the use of flow cytometry and cell sorting in immunological studies. European Journal of Immunology, 47 (10), 1584−1797.10.1002/eji.201646632.
1.1.
2017
Kasela, Silva; Kisand, Kai; Tserel, Liina; Kaleviste, Epp; Remm, Anu; Fischer, Krista; Esko, Tõnu; Westra, Harm-Jan; Fairfax, Benjamin P; Makino, Seiko; Knight, Julian C; Franke, Lude; Metspalu, Andres; Peterson, Pärt; Milani, Lili (2017). Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells. Plos Genetics, 13 (3, 3), ARTN e1006643.10.1371/journal.pgen.1006643.
1.1.
2016
Hetemäki, Iivo; Jarva, Hanna; Kluger, Nicolas; Baldauf, Hanna-Mari; Laakso, Sini; Bratland, Eirik; Husebye, Eystein S; Kisand, Kai; Ranki, Annamari; Peterson, Pärt; Arstila, T Petteri (2016). Anticommensal Responses Are Associated with Regulatory T Cell Defect in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients. Journal of immunology (Baltimore, Md. : 1950), 196 (7), 2955−2964.10.4049/jimmunol.1500301.
1.1.
2016
Bichele, Rudolf; Kisand, Kai; Peterson, Pärt; Laan, Martti (2016). TNF superfamily members play distinct roles in shaping the thymic stromal microenvironment. Molecular Immunology, 72, 92−102.10.1016/j.molimm.2016.02.015.
1.1.
2016
Limbach, Maia; Saare, Mario; Tserel, Liina; Kisand, Kai; Eglit, Triin; Sauer, Sascha; Axelsson, Tomas; Syvänen, Ann-Christine; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2016). Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. Journal of Autoimmunity, 67, 46−56.10.1016/j.jaut.2015.09.006.
1.1.
2016
Laan, Martti; Haljasorg, Uku; Kisand, Kai; Salumets, Andres; Peterson, Pärt (2016). Pregnancy-induced thymic involution is associated with suppression of chemokines essential for T-lymphoid progenitor homing. European Journal of Immunology, 46 (8), 2008−2017.10.1002/eji.201646309.
1.1.
2016
Meyer, Steffen; Woodward, Martin; Hertel, Christina; Vlaicu, Philip; Haque, Yasmin; Kärner, Jaanika; Macagno, Annalisa; Onuoha, Shimobi C; Fishman, Dmytro; Peterson, Hedi; Metsküla, Kaja; Uibo, Raivo; Jäntti, Kirsi; Hokynar, Kati; Wolff, Anette S B; ,; Krohn, Kai; Ranki, Annamari; Peterson, Pärt; Kisand, Kai ... Hayday, Adrian (2016). AIRE-Deficient Patients Harbor Unique High-Affinity Disease-Ameliorating Autoantibodies. Cell, 166 (3), 582−595.10.1016/j.cell.2016.06.024.
1.1.
2015
Kõks, Gea; Uudelepp, Mari-Liis; Limbach, Maia; Peterson, Pärt; Reimann, Ene; Kõks, Sulev (2015). Smoking-Induced Expression of the GPR15 Gene Indicates Its Potential Role in the Chronic Inflammatory Pathologies. The American journal of pathology, 185 (11), 2898−2906.10.1016/j.ajpath.2015.07.006.
1.1.
2015
Kisand, K; Peterson, P (2015). Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy. Journal of Clinical Immunology, 35 (5), 463−478.10.1007/s10875-015-0176-y.
1.1.
2015
Westra, HJ; Arends, D; Esko, T; Peters, MJ; Schurmann, C; Schramm, K; Kettunen, J; Yaghootkar, H; Fairfax, BP; Andiappan, AK; Li, Y; Fu, J; Karjalainen, J; Platteel, M; Visschedijk, M; Weersma, RK; Kasela, S; Milani, L; Tserel, L; Peterson, P ... Franke, L. (2015). Cell Specific eQTL Analysis without Sorting Cells. Plos Genetics, 11 (5), e1005223.10.1371/journal.pgen.1005223.
1.1.
2015
Pekkarinen, PT; Heikkilä, N; Kisand, K; Peterson, P; Botto, M; Daha, MR; Drouet, C; Isaac, L; Helminen, M; Haahtela, T; Meri, S; Jarva, H; Arstila, TP. (2015). Dysregulation of adaptive immune responses in complement C3-deficient patients. European Journal of Immunology, 45 (3), 915−921.10.1002/eji.201444948.
1.1.
2015
Haljasorg, Uku; Bichele, Rudolf; Saare, Mario; Guha, Mithu; Maslovskaja, Julia; Kõnd, Karin; Remm, Anu; Pihlap, Maire; Tomson, Laura; Kisand, Kai; Laan, Martti; Peterson, Pärt (2015). A highly conserved NF-κB-responsive enhancer is critical for thymic expression of Aire in mice. European Journal of Immunology, 45 (12), 3246−3256.10.1002/eji.201545928.
1.1.
2015
Maslovskaja, Julia; Saare, Mario; Liiv, Ingrid; Rebane, Ana; Peterson, Pärt (2015). Extended HSR/CARD domain mediates AIRE binding to DNA. Biochemical and Biophysical Research Communications, 468 (4), 913−920.10.1016/j.bbrc.2015.11.056.
1.1.
2015
Peters, Marjolein J; Joehanes, Roby; Pilling, Luke C; Schurmann, Claudia; Conneely, Karen N; Powell, Joseph; Reinmaa, Eva; Sutphin, George L; Zhernakova, Alexandra; Schramm, Katharina; Wilson, Yana A; Kobes, Sayuko; Tukiainen, Taru; ,; Ramos, Yolande F; Göring, Harald H H; Fornage, Myriam; Liu, Yongmei; Gharib, Sina A; Stranger, Barbara E ... Johnson, Andrew D (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, 8570−8570.10.1038/ncomms9570.
1.1.
2015
Tserel, Liina; Kolde, Raivo; Limbach, Maia; Tretyakov, Konstantin; Kasela, Silva; Kisand, Kai; Saare, Mario; Vilo, Jaak; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2015). Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes. Scientific Reports, 5 (13107), 1−11.10.1038/srep13107.
1.1.
2015
Falorni, Alberto; Bini, Vittorio; Betterle, Corrado; Brozzetti, Annalisa; Castaño, Luis; Fichna, Marta; Kämpe, Olle; Mellgren, Gunnar; Peterson, Pärt; Chen, Shu; Rönnelid, Johan; Seissler, Jochen; Tiberti, Claudio; Uibo, Raivo; Yu, Liping; Lernmark, Åke; Husebye, Eystein (2015). Determination of 21-hydroxylase autoantibodies: inter-laboratory concordance in the Euradrenal International Serum Exchange Program. Clinical Chemistry and Laboratory Medicine, 53 (11), 1761−1770.10.1515/cclm-2014-1106.
6.8.
2015
Peterson, Pärt (2015). Sirt-ainly Aire. Nature immunology, 16 (7), 680−681.10.1038/ni.3195.
1.1.
2014
Kisand, K.; Peterson, P.; Laan, M. (2014). Lymphopenia-induced proliferation in aire-deficient mice helps to explain their autoimmunity and differences from human patients. Frontiers in Immunology, 5 (51), 1−10.10.3389/fimmu.2014.00051.
1.1.
2014
Wolff, AS.; Kärner, J.; Owe, JF.; Oftedal, BE.; Gilhus, NE.; Erichsen, MM.; Kämpe, O.; Meager, A.; Peterson, P.; Kisand, K.; Willcox, N.; Husebye, ES. (2014). Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors. Journal of Immunology, 193 (8), 3880−3890.10.4049/jimmunol.1401068.
1.1.
2014
Laakso, S.M.; Kekäläinen, E.; Heikkilä, N.; Mannerström, H.; Kisand, K.; Peterson, P.; Ranki, A.; Arstila, T.P. (2014). In vivo analysis of helper T cell responses in patients with autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy provides evidence in support of an IL-22 defect. Autoimmunity, 47 (8), 556−562.10.3109/08916934.2014.929666.
1.1.
2014
Zucchelli, Chiara; Tamburri, Simone; Quilici, Giacomo; Palagano, Eleanora; Berardi, Andrea; Saare, Mario; Peterson, Pärt; Bachi, Angela; Musco, Giovanna (2014). Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1. FEBS Journal, 281 (1), 216−231.10.1111/febs.12588.
1.1.
2014
Tserel, Liina; Limbach, Maia; Saare, Mario; Kisand, Kai; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2014). CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing. Immunity and Ageing, 11 (1), Article Number: 1 (1-5).
1.1.
2014
Wolff, Anette S B; Kärner, Jaanika; Owe, Jone F; Oftedal, Bergithe E V; Gilhus, Nils Erik; Erichsen, Martina M; Kämpe, Olle; Meager, Anthony; Peterson, Pärt; Kisand, Kai; Willcox, Nick; Husebye, Eystein S (2014). Clinical and serologic parallels to APS-I in patients with thymomas and autoantigen transcripts in their tumors. Journal of immunology (Baltimore, Md. : 1950), 193 (8), 3880−3890.10.4049/jimmunol.1401068.
1.1.
2013
Kuparinen, Taru; Marttila, Saara; Jylhävä, Juulia; Tserel, Liina; Peterson, Pärt; Jylhä, Marja; Hervonen, Antti; Hurme, Mikko (2013). Cytomegalovirus (CMV)-dependent and -independent changes in the aging of the human immune system: A transcriptomic analysis. Experimental Gerontology, 48 (3), 305−312.10.1016/j.exger.2012.12.010.
1.1.
2013
Wolff, A. S.;Sarkadi, A. K.;Marodi, L.;Karner, J.;Orlova, E.;Oftedal, B. E.;Kisand, K.;Olah, E.;Meloni, A.;Myhre, A. G.;Husebye, E. S.;Motaghedi, R.;Perheentupa, J.;Peterson, P.;Willcox, N.; Meager, A. (2013). Anti-cytokine autoantibodies preceding onset of autoimmune polyendocrine syndrome type I features in early childhood. Journal of Clinical Immunology, 33 (8), 1341−1348.10.1007/s10875-013-9938-6.
1.1.
2013
Kisand, K; Peterson, P. (2013). Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy and other primary immunodeficiency diseases help to resolve the nature of protective immunity against chronic mucocutaneous candidiasis. Current Opinion in Pediatrics, 25 (6), 715−721.10.1097/MOP.0000000000000028.
1.1.
2013
Rice, G. I.; Forte, G. M.; Szynkiewicz, M.; Chase, D. S.; Aeby, A.; Abdel-Hamid, M. S.; Ackroyd, S.; Allcock, R.; Bailey, K. M.; Balottin, U.; Barnerias, C.; Bernard, G.; Bodemer, C.; Botella, M. P.; Cereda, C.; Chandler, K. E.; Dabydeen, L.; Dale, R. C.; De Laet, C.; De Goede, C. G. ... Crow, Y. J. (2013). Assessment of interferon-related biomarkers in Aicardi-Goutieres syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study. The Lancet Neurology, 12 (12), 1159−1169.10.1016/S1474-4422(13)70258-8.
1.1.
2013
Laan, Martti; Peterson, Pärt (2013). The Many Faces of Aire in Central Tolerance. Frontiers in Immunology, 4, 326.
1.1.
2013
Peterson, Pärt; Laan, Martti (2013). Bipotency of thymic epithelial progenitors comes in sequence. European Journal of Immunology, 43 (3), 580−583.10.1002/eji.201343323.
1.1.
2013
Marttila, Saara; Jylhävä, Juulia; Nevalainen, Tapio; Nykter, Matti; Jylhä, Marja; Hervonen, Antti; Tserel, Liina; Peterson, Pärt; Hurme, Mikko (2013). Transcriptional Analysis Reveals Gender-Specific Changes in the Aging of the Human Immune System. PLoS ONE, 8 (6), e66229.10.1371/journal.pone.0066229.
1.1.
2013
Kärner, J.; Meager, A.; Laan, M.; Maslovskaja, J.; Pihlap, M.; Remm, A.; Juronen, E.; Wolff, A. S. B.; Husebye, E. S.; Podkrajšek, K. T.; Bratanic, N.; Battelino, T.; Willcox, N.; Peterson, P.; Kisand, K. (2013). Anti-cytokine autoantibodies suggest pathogenetic links with autoimmune regulator deficiency in humans and mice. Clinical and Experimental Immunology, 171 (3), 263−272.10.1111/cei.12024.
1.1.
2012
Gaetani, Massimiliano; Matafora, Vittoria; Saare, Mario; Spiliotopoulos, Dimitros; Mollica, Luca; Quilici, Giacoma; Chignola, Francesca; Mannella, Valeria; Zucchelli, Chiara; Peterson, Pärt; Bachi, Angela; Musco, Giovanna (2012). AIRE-PHD fingers are structural hubs to maintain the integrity of chromatin-associated interactome. Nucleic Acids Research, 40 (22), 11756−11768.10.1093/nar/gks933.
1.1.
2012
Liiv, Ingrid; Haljasorg, Uku; Kisand, Kai; Maslovskaja, Julia; Laan, Martti; Peterson, Pärt (2012). AIRE-induced apoptosis is associated with nuclear translocation of stress sensor protein GAPDH. Biochemical and Biophysical Research Communications, 423 (1), 32−37.10.1016/j.bbrc.2012.05.057.
1.1.
2012
Saare, M.; Rebane, A.; Rajashekar, B.; Vilo, J., Peterson, P. (2012). Autoimmune regulator is acetylated by transcription coactivator CBP/p300. Experimental and Cellular Research, 318 (14), 1767−78.
1.1.
2012
Wang, Xiaoping; Laan, Martti; Bichele, Rudolf; Kai, Kisand; Scott, Hamish; Peterson, Pärt. (2012). Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Frontiers in Immunology, 1−16.10.3389/fimmu.2012.00019.
1.1.
2011
Kont, V.; Murumägi, A.; Tykocinski, L.O.; Kinkel, S.A.; Webster, K.E.; Kisand, K.; Tserel, L.; Pihlap, M.; Ströbel, P.; Scott, H.S.; Marx, A.; Kyewski, B.; Peterson, P. (2011). DNA methylation signatures of the AIRE promoter in thymic epithelial cells, thymomas and normal tissues. Molecular Immunology, 49 (3), 518−526.10.1016/j.molimm.2011.09.022.
1.1.
2011
Kisand, Kai; Peterson, Pärt (2011). Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy: known and novel aspects of the syndrome. Annals of New York Academy of Sciences, 1246 (1), 77−91.10.1111/j.1749-6632.2011.06308.x.
1.1.
2011
Morrot, Alexandre; Terra-Granado, Eugênia; Pérez, Ana Rosa; Silva-Barbosa, Suse Dayse; Milićević, Novica; Farias-de-Oliveira, Désio Aurélio; Berbert, Luiz Ricardo, Meis, Juliana De; Takiya, Christina Maeda; Beloscar, Juan; Wang, Xiaoping; Kont, Vivian; Peterson, Pärt; Bottasso, Oscar; Savino, Wilson (2011). Chagasic Thymic Atrophy Does Not Affect Negative Selection but Results in the Export of Activated CD4(+)CD8(+) T Cells in Severe Forms of Human Disease. PLoS Neglected Tropical Diseases, 5 (8), e1268−e1268.10.1371/journal.pntd.0001268.
1.1.
2011
Milićević, N.M.; Miljković, M.D.; Milićević, Z.; Labudović-Borović, M.; Wang, X.; Laan, M.; Peterson, P.; Randall, T.D.; Westermann, J. (2011). Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus. Histochemistry and Cell Biology, 135 (6), 593−601.
1.1.
2011
Kisand, Kai; Lilic, Desa; Casanova, Jean-Laurent; Peterson, Pärt; Meager, Anthony; Willcox, Nick (2011). Mucocutaneous candidiasis and autoimmunity against cytokines in APECED and thymoma patients: clinical and pathogenetic implications. European Journal of Immunology, 41 (6), 1517−1527.10.1002/eji.201041253.
1.1.
2011
Tserel, L.; Runnel, T.; Kisand, K.; Pihlap, M.; Bakhoff, L.; Kolde, R.; Peterson, H.; Vilo, J.; Peterson, P.; Rebane, A. (2011). MicroRNA Expression Profiles of Human Blood Monocyte-derived Dendritic Cells and Macrophages Reveal miR-511 as Putative Positive Regulator of Toll-like Receptor 4. Journal of Biological Chemistry, 286 (30), 26487−26495.10.1074/jbc.M110.213561.
1.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tõnis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics, 11, 642.10.1186/1471-2164-11-642.
1.1.
2010
Colomé, N.; Collado, J.; Bech-Serra, J.J.; Liiv, I.; Antón, L.C.; Peterson, P.; Canals, F.; Jaraquemada, D.; Alvarez, I. (2010). Increased apoptosis after autoimmune regulator expression in epithelial cells revealed by a combined quantitative proteomics approach. Journal of Proteome Research, 9 (5), 2600−2609.
1.1.
2010
Kyewski, B.; Peterson, P. (2010). Aire, master of many trades. Cell, 140 (1), 24−26.10.1016/j.cell.2009.12.036.
1.1.
2010
Kisand, K.; Bøe Wolff, A.S.; Podkrajsek, K.T.; Tserel, L.; Link, M.; Kisand, K.V.; Ersvaer, E.; Perheentupa, J.; Erichsen, M.M.; Bratanic, N.; Meloni, A.; Cetani, F.; Perniola, R.; Ergun-Longmire, B.; Maclaren, N.; Krohn, K.J.; Pura, M.; Schalke, B.; Ströbel, P., Leite, M.I.; Battelino, T. ... Meager, A. (2010). Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. Journal of Experimental Medicine, 207 (2), 299−308.10.1084/jem.20091669.
1.1.
2010
Poliani PL, Kisand K, Marrella V, Ravanini M, Notarangelo LD, Villa A, Peterson P, Facchetti F (2010). Human Peripheral Lymphoid Tissues Contain Autoimmune Regulator-Expressing Dendritic Cells. American Journal of Pathology, 176 (3), 1104−1112.10.2353/ajpath.2010.090956.
1.1.
2010
Milićević, Ž.; Milićević, N.M.; Laan, M.; Peterson, P.; Kisand, K.; Scott, H.S.; Westermann, J. (2010). Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)-deficient mice. Immunology and Cell Biology, 88, 50−56.10.1038/icb.2009.55.
5.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tonis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Gene Expression and Epigenetic Changes in Differentiation of Human Macrophages and Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 526−526.
5.1.
2010
Rebane, Ana; Tserel, Liina; Kisand, Kai; Backhoff, Lairi; Runnel, Toomas; Kolde, Raivo; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Balanced Expression of miRNA-S Secures Differentiation and Maturation of Human Blood Monocyte Derived Dendritic Cells. Scandinavian Journal of Immunology, 71 (6), 512−513.
1.1.
2009
Holländer, G.A.; Peterson, P. (2009). Learning to be tolerant: how T cells keep out of trouble. Journal of Internal Medicine, 265 (5), 541−546.
1.1.
2009
Laan, M.; Kisand, K.; Kont, V.; Möll, K.; Tserel, L.; Scott, H.S.; Peterson, P. (2009). Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. Journal of Immunology, 183 (12), 7682−7691.10.4049/jimmunol.0804133.
1.1.
2009
Milićević, N.M.; Milićević, Z.; Miljković, M.D.; Labudović-Borović, M.; Laan, M.; Peterson, P.; Kisand, K.; Scott, H.S.; Qu, N.; Westermann, J. (2009). Metallophilic macrophages are fully developed in the thymus of autoimmune regulator (Aire)-deficient mice. Histochemistry and Cell Biology, 131 (5), 643−649.
1.1.
2009
Chignola, F.; Gaetani, M.; Rebane, A.; Org, T.; Mollica, L.; Zucchelli, C.; Spitaleri, A.; Mannella, V.; Peterson, P.; Musco, G. (2009). The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Research, 37 (9), 2951−2961.
1.1.
2009
Hubert, FX.; Kinkel, SA.; Crewther, PE.; Cannon, PZ.; Webster, KE.; Link, M.; Uibo, R.; O'Bryan, MK.; Meager, A.; Forehan, SP.; Smyth, GK.; Mittaz, L.; Antonarakis, SE.; Peterson, P.; Heath, WR.; Scott, HS. (2009). Aire-deficient C57BL/6 mice mimicking the common human 13-base pair deletion mutation present with only a mild autoimmune phenotype. Journal of Immunology, 182 (6), 3902−3918.
1.1.
2009
Hansenne, I.; Louis, C.; Martens, H.; Dorban, G.; Charlet-Renard, C.; Peterson, P.; Geenen, V. (2009). Aire and Foxp3 expression in a particular microenvironment for T cell differentiation. Neuroimmunomodulation, 16 (1), 35−44.
1.1.
2008
Ferguson, B.J.; Alexander, C.E.; Rossi, S.W.; Liiv, I.; Rebane, A.; Worth, C.L.; Wong, J.; Laan, M.; Peterson, P.; Jenkinson, E.J.; Anderson, G.; Scott, H.S.; Cooke, A.; Rich, T. (2008). AIRE's card revealed; A new structure for central tolerance provokes transcriptional plasticity. Journal of Biological Chemistry, 283 (3), 1723−1731.10.1074/jbc.M707211200.
1.1.
2008
Musco, G.; Peterson, P. (2008). PHD finger of autoimmune regulator: an epigenetic link between the histone modifications and tissue-specific antigen expression in thymus. Epigenetics, 3 (6), 310−314.
1.1.
2008
Peterson, P.; Org, T.; Rebane, A. (2008). Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nature Reviews Immunology, 8 (12), 948−957.10.1038/nri2450.
1.1.
2008
Ströbel, P.; Chuang, W.Y.; Chuvpilo, S.; Zettl, A.; Katzenberger, T.; Kalbacher, H.; Rieckmann, P.; Nix, W.; Schalke, B.; Gold, R.; Müller-Hermelink, H.K.; Peterson, P.; Marx, A. (2008). Common cellular and diverse genetic basis of thymoma-associated myasthenia gravis: role of MHC class II and AIRE genes and genetic polymorphisms. Annals of New York Academy of Sciences, 1132, 143−156.10.1196/annals.1405.018.
1.1.
2008
Meager, A.; Peterson, P.; Willcox, N. (2008). Hypothetical review: thymic aberrations and type-I interferons; attempts to deduce autoimmunizing mechanisms from unexpected clues in monogenic and paraneoplastic syndromes. Clinical and Experimental Immunology, 154 (1), 141−151.10.1111/j.1365-2249.2008.03739.x.
1.1.
2008
Kisand, K.; Link, M.; Wolff, A.S. B.; Meager, A.; Tserel, L.; Org, T.; Murumägi, A.; Uibo, R.; Willcox, N.; Podkrajšek Trebušak, K.; Battelino, T.; Lobell, A.; Kämpe, O.; Perheentupa, J.; Krohn, K.; Scott, H.S.; Husebye, E.S.; Peterson, P. (2008). Interferon autoantibodies associated with AIRE-deficiency decrease the expression of IFN-stimulated genes. Blood, 112 (7), 2657−2666.
1.1.
2008
Ferguson, B.J.; Cooke, A.; Peterson, P.; Rich, T. (2008). Death in the AIRE. Trends in Immunology, 29 (7), 306−312.10.1016/j.it.2008.03.004.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta - Molecular Cell Research, 1783 (1), 74−83.10.1016/j.bbamcr.2007.09.003.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376.10.1038/embor.2008.11.
1.1.
2008
Reimand, K.; Perheentupa, J.; Link, M.; Krohn, K.; Peterson, P.; Uibo, R. (2008). Testis-expressed protein TSGA10 – an autoantigen in Autoimmune Polyendocrine Syndrome Type I. International Immunology, 20 (1), 39−44.10.1093/intimm/dxm118.
1.1.
2008
Kont, V.; Laan, M.; Kisand, K.; Merits, A.; Scott, H.S.; Peterson, P. (2008). Modulation of Aire regulates the expression of tissue-restriced antigens. Molecular Immunology, 45 (1), 25−33.
1.1.
2007
Gombos, Z.; Hermann, R.; Kiviniemi, M.; Nejentsev, S.; Reimand, K.; Fadeyev, V.; Peterson, P.; Uibo, R.; Ilonen, J. (2007). Analysis of extended human leukocyte antigen haplotype association with Addison's disease in three populations. European Journal of Endocrinology, 157 (6), 757−761.10.1530/EJE-07-0290.
1.1.
2007
Strobel, P.; Murumagi, A.; Klein, R.; Luster, M.; Lahti, M.; Krohn, K.; Schalke, B.; Nix, W.; Gold, R.; Rieckmann, P.; Toyka, K.; Burek, C.; Rosenwald, A.; Muller-Hermelink, H.K.; Pujoll-Borrell, R.; Meager, A.; Willcox, N.; Peterson, P.; Marx, A. (2007). Deficiency of the autoimmune regulator AIRE in thymomas is insufficient to elicitautoimmune polyendocrinopathy syndrome type 1 (APS-1). The Journal of Pathology, 211 (5), 563−571.
1.2.
2007
O'Dwyer, D.T.; McElduff, P.; Peterson, P.; Perheentupa, J.; Crock, P.A. (2007). Pituitary autoantibodies in autoimmune polyendocrinopathy - candidiasis - ectodermal dystrophy (APECED). Acta bio-medica de L'Ateneo parmense : organo della Societa di medicina e scienze naturali di Parma, 78, 248−254.
1.3.
2007
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U.; Mollica, L.; Musco, G.; Peterson, P. (2007). Autoimmuunsuse regulaator (AIRE) valgu PHD tsink sõrm seondub geeniekspressiooni aktiviseerimiseks mittemetüleeritud histoon H3K4-ga. Eesti Arst, 9, 685.
3.1.
2007
Kämpe, O.; Peterson, P. (2007). Autoimmune Polyglandular Syndrome Type 1. In: Weetman, A. P. (_EditorsAbbr). Autoimmune Diseases in Endocrinology (303−410).. Humana Press.
5.1.
2007
Ilonen, J.; Gombos, Z.; Hermann, R.; Kiviniemi, M.; Nejentsev, S.; Reimand, K.; Fadeyev, V.; Peterson, P.; Uibo, R. (2007). Type 1 diabetes and Addison's disease are associated with different HLA-DRB1*0404-DQB1*0302 haplotypes. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 65: 37th Annual Meeting of the Scandinavian-Society-for-Immunology; Turku, FINLAND, JUN 06-09, 2007. BLACKWELL PUBLISHING, 9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLAND: Blackwell Publishing, 601−602. (6).
1.1.
2006
Zhang, B., Wang, Z., Ding, J., Peterson, P., Gunning, W.T., Ding, H.F. (2006). NF-kappaB2 is required for the control of autoimmunity by regulating the development of medullary thymic epithelial cells. Journal of Biological Chemistry, 281 (50), 38617−38624.
1.1.
2006
Viiri, K.M.; Korkeamaki, H.; Kukkonen, M.K.; Nieminen, L.K.; Lindfors, K.; Peterson, P.; Maki, M.; Kainulainen, H.; Lohi, O. (2006). SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus. Nucleic Acids Research, 34 (11), 3288−3298.
1.1.
2006
Meager, A.; Visvalingam, K.; Peterson, P.; Moll, K.; Murumagi, A.; Krohn, K.; Eskelin, P.; Perheentupa, J.; Husebye, E.; Kadota, Y.; Willcox, N. (2006). Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1. PLOS Medicine, 3 (7), 1151−1164.
1.1.
2006
Murumagi, A.; Silvennoinen, O.; Peterson, P. (2006). Ets transcription factors regulate AIRE gene promoter. Biochemical and Biophysical Research Communications, 348 (2), 768−774.
3.1.
2006
Peterson, P.; Uibo, R.; Kämpe, O. (2006). Polyendocrine syndromes. In: Rose, N.R.; Mackay, I.R. (_EditorsAbbr). The Autoimmune Diseases, 4th Edition (515−526).. Academic Press.
1.1.
2005
Pitkanen, J.; Rebane, A.; Rowell, J.; Murumagi, A.; Strobel, P.; Moll, K.; Saare, M.; Heikkila, J.; Doucas, V.; Marx, A.; Peterson, P. (2005). Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochemical and Biophysical Research Communications, 333 (3), 944−953.10.1016/j.bbrc.2005.05.187.
1.1.
2005
Tawfik, S.; Azim, M.A.; Peterson, P.; Donaldson, M.D. (2005). Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy presenting with severe keratopathy in an Egyptian patient with a homozygous R139X mutation. Hormone Research, 64 (2), 96−99.
1.1.
2005
Karenko, L.; Hahtola, S.; Paivinen, S.; Karhu, R.; Syrja, S.; Kahkonen, M.; Nedoszytko, B.; Kytola, S.; Zhou, Y.; Blazevic, V.; Pesonen, M.; Nevala, H.; Nupponen, N.; Sihto, H.; Krebs, I.; Poustka, A.; Roszkiewicz, J.; Saksela, K.; Peterson, P.; Visakorpi, T. ... Ranki, A. (2005). Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue. Cancer research, 65 (18), 8101−8110.
1.1.
2005
Tuomela, M.; Malm, M.; Wallen, M.; Stanescu, I; Krohn, K.; Peterson, P. (2005). Biodistribution and general safety of a naked DNA plasmid, GTU®-MULTIHIV, in a rat, using a quantitative PCR method. Vaccine, 23 (7), 890−896.
1.1.
2005
Peterson, P.; Peltonen, L. (2005). Autoimmune polyendocrinopathy syndrome type 1 (APS1) and AIRE gene: New views on molecular basis of autoimmunity. Journal of Autoimmunity, 25, 49−55.
1.1.
2005
Webster, KE.; O'Bryan, MK.; Fletcher, S.; Crewther, PE.; Aapola, U.; Craig, J.; Harrison, DK.; Aung, H.; Phutikanit, N.; Lyle, R.; Meachem, SJ.; Antonarakis, SE.; de Krester, DM.; Hedger, MP.; Peterson, P.; Carroll, BJ.; Scott, HS. (2005). Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America, 102 (11), 4068−4073.
1.1.
2005
Pitkanen, J.; Rebane, A.; Rowell, J.; Murumagi, A.; Strobel, P.; Moll, K.; Heikkila, J.; Doucas, V.; Marx, A.; Peterson, P. (2005). Cooperative activation of transcription by autoimmune regulator AIRE and CBP. Biochemical and Biophysical Research Communications, 333 (3), 944−953.
5.2.
2005
Reimand, K.; Link, M.; Peterson, P.; Uibo, R. (2005). Tsga10 – tõenäone elundispetsiifiline autoantigeen APS I sündroomi korral. Eesti Arst, 84 (9), 678−679.
1.1.
2004
Stjernberg-Salmela, S.; Pettersson, T.; Karenko, L.; Blazevic, V.; Nevala, H.; Pitkänen, S.; Peterson, P.; Ranki, A. (2004). A novel tumour necrosis factor receptor mutation in a Finnish family with periodic fever syndrome. Scandinavian Journal of Rheumatology, 33 (3), 140−144.
1.1.
2004
Ströbel, P.; Rosenwald, A.; Baiersdorf, N.; Kerkau, T.; Elert, O.; Murumägi, A.; Sillanpää, N.; Peterson, P.; Hummel, V.; Rieckmann, P.; Burek, C.; Schalke, B.; Nix, W.; Kiefer, R.; Müller-Hermelink, H. K.; Marx, A. (2004). Selective loss of regulatory T cells in thymomas. Annals of Neurology, 56 (6), 901−904.
1.1.
2004
Sillanpää, N.; Magureanu, C. M.; Murumägi, A.; Reinikainen, A.; Manninen, A.; Heino, M.; Ranki, A.; Saksela, K.; Krohn, K.; Lahesmaa, R.; Peterson, P. (2004). Autoimmune regulator induced changes in the gene expression profile of monocyte-dendritic cell-lineage. Molecular Immunology, 41 (12), 1185−1198.10.1016/j.molimm.2004.06.004.
1.1.
2004
Akiyoshi, H.; Hatakeyama, S.; Pitkänen, J.; Mouri, Y.; Doucas, V.; Kudoh, J.; Tsurugaya, K.; Uchida, D.; Matsushima, A.; Oshikawa, K.; Nakayama, K. I.; Shimizu, N.; Peterson, P.; Matsumoto, M. (2004). Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner. Journal of Biological Chemistry, 279 (32), 33984−33991.
1.1.
2004
Peterson, P.; Pitkanen, J.; Sillanpaa, N.; Krohn, K. (2004). Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED): a model disease to study molecular aspects of endocrine autoimmunity. Clinical and Experimental Immunology, 135 (3), 348−357.
1.1.
2004
Aapola, U.; Maenpaa, K.; Kaipia, A.; Peterson, P. (2004). Epigenetic modifications affect Dnmt3L expression. Biochemical Journal, 380, 705−713.
1.2.
2004
Krohn, K.; Peterson, P. (2004). The central role of AIRE in thymic induction of tolerance to self antigens. Current Opinion in Endocrinology and Diabetes, 11 (1), 26−30.
3.2.
2004
Peterson, P. (2004). Autoimmuunsus: rikutud tasakaal. Tasakaalu teooria (86−88).. Tartu: Sulemees.
1.1.
2003
Chin, R. K.; Lo, J. C.; Kim, O.; Blink, S. E.; Christiansen, P. A.; Peterson, P.; Wang, Y.; Ware, C.; Fu, Y. X. (2003). Lymphotoxin pathway directs thymic Aire expression. Nature immunology, 4 (11), 1121−1127.
1.1.
2003
Pitkänen, J.; Peterson, P. (2003). Autoimmune regulator: from loss of function to autoimmunity. Genes and Immunity, 4 (1), 12−21.
1.1.
2003
Murumagi, A.; Vahamurto, P.; Peterson, P. (2003). Characterization of regulatory elements and methylation pattern of the autoimmune regulator (AIRE) promoter. Journal of Biological Chemistry, 278 (22), 19784−19790.
6.3.
2003
Peterson, P. (2003). Autoimmuunhaigused: omad muutuvad võõrasteks. Eesti Loodus, 9, 38−40.
1.1.
2002
Nevala, H.; Karenko, L.; Stjernberg, S.; Raatikainen, M.; Suomalainen, H.; Lagerstedt, A.; Rauta, J.; McDermott, M. F.; Peterson, P.; Pettersson, T.; Ranki, A. (2002). A Novel Mutation in the Third Extracellular Domain of the Tumor Necrosis Factor Receptor 1 in a Finnish Family With Autosomal-Dominant Recurrent Fever. Arthritis and Rheumatism, 46 (4), 1061−1066.10.1002/art.10224.
1.1.
2002
Liiv, I.; Teesalu, K.; Peterson, P.; Clemente, MG.; Perheentupa, J.; Uibo, R. (2002). Epitope mapping of cytochrome P450 cholesterol side-chain cleavage enzyme by sera from patients with autoimmune polyglandular syndrome type 1. European Journal of Endocrinology, 146 (1), 113−119.
1.1.
2002
Aapola, U.; Liiv, I.; Peterson, P. (2002). Imprinting regulator DNMT3L is a transcriptional repressor associated with histone deacetylase activity. Nucleic Acids Research, 30 (16), 3602−3608.
5.1.
2002
Nikopensius, T.; Peterson, P.; Kurg, A.; Krohn, KJE.; Saha, M.; Ilonen, J.; Knip, M.; Metspalu, A. (2002). AIRE gene polymorphisms in Finnish patients with type 1 diabetes. European Journal of Human Genetics, 10, 164−164.
1.1.
2001
Tähtinen, M.; Strengell, M.; Collings, A.; Pitkänen, J.; Hakkarainen, K.; Ustav, M.; Wahren, B.; Peterson, P.; Kohleisen, B.; Ranki, A.; Krohn, K. (2001). DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating bovine papilloma virus based pBN-vector. Vaccine, 19, 2039−2047.
1.1.
2001
Aapola, U.; Lyle, R.; Krohn, K.; Antonarakis, S. E.; Peterson, P. (2001). Isolation and Tissue Distribution of Mouse Dnmt3l gene. Cytogenetics and Cell Genetics, 92, 122−126.
1.1.
2001
Heino, H.; Peterson, P.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E.; Scott, H. S.; Krohn, K. (2001). APECED mutations in the Autoimmune Regulator (AIRE) gene. Human Mutation, 18 (3), 205−211.
1.1.
2001
Cihakova, D.; Trebusak, Heino, M.; Fadeyev, V.; Tiulpakov, A.; Battelino, T.; Tar, A.; Halasz, Z.; Blumel, P.; Tawfik, S.; Krohn, K.; Lebl, J.; Peterson, P. (2001). Novel AIRE mutations and P450 cytochrome autoantibodies in Central and Eastern European patients with APECED. Human Mutation, 18 (3), 225−232.
1.1.
2001
Pitkänen, J.; Vähämurto, P.; Krohn, K.; Peterson, P. (2001). Subcellular localization of the autoimmune regulator protein: characterization of nuclear targeting and transcriptional activation domain. Journal of Biological Chemistry, 276, 19597−19602.
1.2.
2001
Lebl, J.; Cihakova, D.; Trebusak, K.; Heino, M.; Battelino, T.; Halasz, Z.; Tar, A.; Blumel, P.; Fadejev, V.; Tyulpakov, A.; Krohn, K.; Peterson, P. (2001). Autoimmune Polyglandular Syndrome-1 (APS-1; APECED) in Central and Eastern Europe: Novel Mutations of AIRE Gene and P450 Cytochrome Autoantibodies. Pediatric Research, 49, 122−122.
1.1.
2000
Aapola, U.; Shibuya, K.; Scott, H. S.; Ollila, O.; Vihinen, M.; Heino, M.; Shintani, A.; Kawasaki, K.; Minoshima, S.; Krohn, K.; Antonarakis, S. E.; Shimizu, N.; Kudoh, J.; Peterson, P. (2000). Isolation and initial characterization of a novel zinc finger gene, DNMT3L on 21q22.3, related to cytosine-5-methyltransferase 3 gene family. Genomics, 65, 293−298.
1.1.
2000
Pitkänen, J.; Doucas, V.; Sternsdor, T.; Nakajima, T.; Aratani, S.; Jensen, K.; Will, H.; Vähämurto, P.; Ollila, J.; Vihinen, M.; Scott, H. S.; Antonarakis, S. E.; Kudoh, J.; Shimizu, N.; Krohn, K.; Peterson, P. (2000). The autoimmune regulator protein has transcriptional transactivating properties and interacts with common co-activator CBP. Journal of Biological Chemistry, 275, 16802−16809.
1.1.
2000
Heino, M.; Peterson, P.; Sillanpää, N.; Guérin, S.; Wu, L.; Naquet, P.; Anderson, G.; Scott, H. S.; Antonarakis, S. E.; Jenkinson, E. J.; Krohn, K. (2000). RNA and protein expression of the murine Autoimmune Regulator gene (Aire) in normal, RelB deficient and in NOD mouse. European Journal of Immunology, 30, 1884−1893.
1.1.
2000
Peterson, P.; Uibo, R.; Krohn, KJE. (2000). Adrenal autoimmunity: Results and developments. Trends in endocrinology and metabolism: TEM, 11 (7), 285−290.
1.1.
2000
Reimand, K.; Peterson, P.; Hyoty, H.; Uibo, R.; Cooke, I.; Weetman, AP.; Krohn, KJE. (2000). 3 beta-hydroxysteroid dehydrogenase autoantibodies are rare in premature ovarian failure. Journal of Clinical Endocrinology and Metabolism, 85 (6), 2324−2326.
1.1.
1999
Collings, A.; Pitkanen, J.; Strengell, M.; Tahtinen, M.; Pitkanen, J.; Lagerstedt, A.; Hakkarainen, K.; Ovod, V.; Sutter, G.; Ustav, M.; Ustav, E.; Mannik, A; Ranki, A; Peterson, P.; Krohn, K. (1999). Humoral and cellular response to HIV-1 Nef in mice DNA-immunized with non-replicating and self-replicating expression vectors. Vaccine, 18, 460−467.
1.1.
1999
Heino, M.; Scott, H. S.; Chen, Q.; Peterson, P.; Mäenpää, U.; Papasavvas, M. P.; Mittaz, L.; Barras, C.; Rossier, C.; Stratakis, A.; Chrousos, G.; Nagamine, K.; Kudoh, J.; Shimizu, N.; Maclaren, N.; Antonarakis, S. E.; Krohn, K. (1999). Mutation analyses of Northern American APS-1 patients. Human Mutation, 13 (1), 69−74.
1.1.
1999
Heino, M.; Peterson, P.; Kudoh, J.; Nagamine, K.; Lagerstedt, A.; Ovod, V.; Ranki, A.; Rantala, I.; Nieminen, M.; Tuukkanen, J.; Scott, H.S.; Antonarakis, S.E.; Shimizu, N.; Krohn, K. (1999). Autoimmune regulator (AIRE) is expressed in the cells regulating immune tolerance in thymus medulla. Biochemical and Biophysical Research Communications, 257 (3), 821−825.
1.1.
1999
Mittaz, L.; Rossier, C.; Heino, M.; Peterson, P.; Krohn, K. J. E.; Gos, A.; Morris, M. A.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E.; Scott, H. S. (1999). Isolation and characterization of the mouse Aire gene. Biochemical and Biophysical Research Communications, 255 (2), 483−490.
1.1.
1999
Seissler, J.; Schott, M.; Steinbrenner, H.; Peterson, P.; Scherbaum, W. A. (1999). Autoantibodies to adrenal cytochrome P450 antigens in isolated Addison’s disease and autoimune polyendocrine syndrome type II. Experimental and Clinical Endocrinology of Diabetes, 107, 208−213.
1.1.
1999
Beltran-Valero, D.; Peterson, P.; Luopajärvi, K.; Matintalo, P.; Alho, A.; Konttinen, Y.; Krohn, K.; Rodriguez, S.; Ranki, A. (1999). Mutational analysis of the HGO gene in Finnish alkaptonuria patients. American Journal of Medical Genetics, 36 (12), 922−923.
1.3.
1999
Fadejev, V.V.; Peterson, P.; Ovod, V.; Melnitchenko, G.A.; Dedov, I.I.; Krohn, K. (1999). Antibodies to steroidogenic enzymes 21-hydroxylase, 17a-hydroxylase and side-chain cleavage enzyme in etiological diagnostics of Addison's disease and autoimmune polyglandular syndromes. Problemy endokrinologii (Moskva), 45/6, 24−28.
6.3.
1999
Peterson, P. (1999). Tagasivaade teadmatusse ehk kust me eestlased tuleme? Horisont, 33 (1), 22−25.
1.1.
1998
Scott, H. S.; Kyriakou, D.; Peterson, P.; Heino, H.; Tähtinen, M.; Krohn, K.; Chen, H.; Rossier, C.; Lalioti, M. D.; Antonarakis, S. E. (1998). Characterization of a novel gene, C21orf2, an human chromosome 21q22.3 and its exclusion as the APECED gene by mutation analysis. Genomics, 47, 64−70.
1.1.
1998
Scott, H.S.; Heino, M.; Peterson, P.; Mittaz, L.; Lalioti, M.D.; Betterle, C.; Cohen, A.; Seri, M.; Lerone, M.; Romeo, G.; Collin, P.; Salo, M.; Metcalfe, R.; Weetman, A.; Papasavvas, M.P.; Rossier, C.; Nagamine, K.; Kudoh, J.; Shimizu, N.; Krohn, K.J.E. ... Antonarakis, S.E. (1998). Common mutations in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients of different origins. Molecular Endocrinology, 12 (8), 1112−1119.
1.1.
1998
Peterson, P.; Nagamine, K.; Scott, H. S.; Heino, M.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E.; Krohn, K. (1998). APECED: a monogenic autoimmune disease providing new clues to self tolerance. Trends in Immunology, 9, 19, 384−386.
1.1.
1998
Rosatelli, M.; Meloni, A.; Devoto, M.; Cao, A.; Scott, H. S.; Peterson, P.; Heino, M.; Krohn, K.; Nagamine, K.; Kudoh, J.; Shimizu, N.; Antonarakis, S. E. (1998). A common mutation in Sardinian autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy patients. Human Genetics, 103 (4), 428−434.
1.1.
1998
Kemp, EH.; Ajjan, RA.; Husebye, ES.; Peterson, P.; Uibo, R.; Imrie, H.; Pearce, SHS.; Watson, PF.; Weetman, AP. (1998). A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients. Clinical Endocrinology, 49 (5), 609−613.
1.3.
1998
Peterson, P.; Heino, M.; Krohn, K. (1998). Immunological and genetic background of APECED syndrome. Duodecim, 114 (15), 1458−1464.
3.1.
1998
Peterson, P.; Uibo, R.; Krohn, K.; Weetman, A. (1998). Addison's disease and related polyendocrinopathies. In: Endocrine Autoimmunity and Associated Conditions (163 −182).. Springer-Verlag.
1.1.
1997
Peterson, P.; Salmi, H.; Hyöty, H.; Miettinen, A.; Ilonen, J.; Reijonen, H.; Åkerblom, H.; Krohn, K. (1997). Steroid 21-hydroxylase autoantibodies in insulin-dependent diabetes mellitus. Clinical Immunology and Immunopathology (continued as Clinical Immunology), 82 (1), 37−42.
1.1.
1997
Krohn, K.; Ovod, V.; Vilja, P.; Heino, M.; Scott, H.; Kyriakou, D. S.; Antonarakis, S. E.; Jacobs, H. T.; Isola, I.; Peterson, P. (1997). Immunochemical characterization of a novel mitochondrially located protein encoded by a nuclear gene within the DFNB8/10 critical region on 21q22.3. Biochemical and Biophysical Research Communications, 238 (3), 806−810.
1.1.
1997
Nagamine, K.; Peterson, P.; Scott, H. S.; Kudoh, J.; Minoshima, S.; Heino, M.; Krohn, K. J. E.; Lalioti, M. D.; Mullis, P. E.; Antonarakis, S. E.; Kawasaki, K.; Asakawa, S.; Ito, F.; Shimizu, N. (1997). Positional cloning of the APECED gene. Nature Genetics, 17, 393−397.
1.1.
1997
Uibo, R.; Uibo, O.; Reimand, K.; Peterson, P.; Krohn, K. (1997). Characterization by molecular cloning an antigen reactive with antireticulin antibodies. B Lymphocytes and Autoimmunity, 815, 509−511.
1.1.
1997
Peterson, P., Uibo, R., Peranen, J., Krohn, K. (1997). Immunoprecipitation of steroidogenic enzyme autoantigens with autoimmune polyglandular syndrome type I (APS I) sera; further evidence for independent humoral immunity to P450c17 and P450c21. Clinical and Experimental Immunology, 107 (2), 335−340.
1.3.
1997
Vaha-Kreula, T., Luopajarvi, K., Peterson, P., Kuokkanen, K., Ranki, A. (1997). Mystery of the blue man: alkaptonuria. Duodecim, 113 (21), 2175−2179.
3.1.
1997
Uibo, R.; Uibo, O.; Peterson, P.; Reimand, K.; Krohn, K. (1997). Molecular cloning of antigen, reactive with reticulin antibodies. In: Slikker, W.; Trembly, B. (_EditorsAbbr). Neuroprotective Agents: Third International Conference (511−513).. New York Academy of Sciences. (Annals of the New York academy of Sciences; 825).
1.1.
1996
Peterson, P.; Perheentupa, J.; Krohn, K. (1996). Detection of candidal antigens in autoimmune polyglandular syndrome type I. Clinical and Diagnostic Laboratory Immunology, 3 (3), 290−294.
2.3.
1996
Peterson, P. (1996). Disease-associated antigens and HLA in autoimmune Addison's disease and polyglandular syndromes. (Doktoritöö). Tampere: University of Tampere.
2.3.
1996
Peterson, P. (1996). Disease-associated antigens and HLA in autoimmune Addison's disease and polyglandular syndromes. (University of Tampere). Tampere: University of Tampere.
1.1.
1995
Peterson, P.; Partanen, J.; Aavik, E.; Salmi, H.; Krohn, K. (1995). Steroid 21-hydroxylase gene polymorphism in Addison's disease patients. Tissue Antigens, 46 (1), 63−67.
1.1.
1994
Ranki, A.; Aavik, E.; Peterson, P.; Schauman, K.; Nurmilaakso, P. (1994). Successful amplification of DNA specific for Finnish Borrelia Burgdorferi-isolates in erythema chronicum migrans but not in circumscribed scleroderma lesions. The Journal of Investigative Dermatology, 102, 339−345.
1.1.
1994
Peterson, P.; Krohn, K. (1994). Mapping of b-cell epitopes on steroid 17-alpha-hydroxylase, an autoantigen in autoimmune polyglandular syndrome type-i. Clinical and Experimental Immunology, 1 (98), 104−109.
1.1.
1994
Partanen, J.; Peterson, P.; Westman, P.; Aranko, S.; Krohn, K. (1994). Major histocompatibility complex class-ii and class-iii in Addisons-disease - MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility. Human Immunology, 41, 135−140.
1.1.
1994
Uibo, R.; Aavik, E.; Peterson, P.; Perheentupa, J.; Arako, S.; Pelkonen, R.; Krohn, K.J.E. (1994). Autoantibodies to cytochrome-p450 enzymes p450scc, p450c17, and p450c21 in autoimmune polyglandular disease type-i and type-ii and in isolated addisons-disease. Journal of Clinical Endocrinology and Metabolism, 78 (2), 323−328.
1.1.
1992
Krohn, K.; Uibo, R.; Aavik, E.; Peterson, P.; Savilahti, K. (1992). Identification by molecular-cloning of an autoantigen associated with addisons-disease as steroid 17-alpha-hydroxylase. Lancet, 339 (8796), 770−773.
6.7.
1992
Peterson, Pärt (1992). Identification of autoantigenic B cell epitopes on human steroid 17[alfa]-hydroxylase, an autoantigen of Addison's disease in type I polyglandural syndrome : the academic research work for attaining a degree of Master of Sciences at University of Tartu. Tartu: University of Tartu.
6.7.
1992
Peterson, P. (1992). Identification of autoantigenic B cell epitopes on human steroid 17[alfa]-hydroxylase, an autoantigen of Addison's disease in type I polyglandural syndrome : the academic research work for attaining a degree of Master of Sciences at University of Tartu. (University of Tartu; University of Tampere). Tartu: University of Tartu.

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18.04.2019
Detailne otsing
  • Leitud 21 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF6663AIRE geeni ekspressioon dendriitrakkudes ja mõju kemokiini toodangule01.01.200631.12.2009Pärt PetersonTartu Ülikool; Tartu Ülikool, Arstiteaduskond53 213,99 EUR
2.2.VMVBS18541APECEDiga patsientidest kloneeritud IFN-a-le spetsiifilised autoantikehad01.08.201831.07.2020Kai KisandTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut69 600,00 EUR
MUUMARMP05115RAutoimmune polyendorcine syndrome type I - a rare disorder of childhood as a model for autoimmunity01.05.200501.05.2008Pärt PetersonTartu Ülikool233 999,78 EUR
2.2.VMVBS18393B cell repertoire analysis in APS-I patients01.08.201831.01.2021Pärt PetersonTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut109 200,00 EUR
MUUSARMP12203EEGIDA - Autoimmunsuse epigeneetilised mehhanismid01.09.201231.12.2013Pärt PetersonTartu Ülikool; Tartu Ülikool, Arstiteaduskond51 360,00 EUR
ETFETF8169Epigeneetilised regulatsioonid immuuntolerantsuses01.01.201031.12.2012Pärt PetersonTartu Ülikool, Arstiteaduskond57 542,29 EUR
MUUMARMP11049ESTOFINN projekt01.03.201131.12.2011Pärt PetersonTartu Ülikool; Tartu Ülikool, Arstiteaduskond87 500,00 EUR
TKSLTMR16142T (TK142)Genoomika ja Siirdemeditsiini Tippkeskus (TK142)01.01.201601.03.2023Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu4 474 349,50 EUR
MUUMARMP12106ImmunoQure Projekt01.04.201231.03.2013Pärt PetersonTartu Ülikool232 800,00 EUR
IUTIUT2-2Immuuntolerantsuse mehhanismid01.01.201331.12.2018Pärt PetersonTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut1 311 000,00 EUR
MUUSARMP13001T (3.2.0701.12-0049)Interleukiinid psoriaasi diagnostikas01.09.201231.08.2015Pärt PetersonTartu Ülikool289 975,00 EUR
MJDMJD164Mis reguleerib autoimmuunset reguleerijat?01.06.201131.05.2014Mithu GuhaTartu Ülikool; Tartu Ülikool, Arstiteaduskond94 080,00 EUR
MUUVARMP04002Novel approaches to pathogenesis, diagnosis and treatment of autoimmune diseases based on new insights into thymus-dependent self-tolerance01.01.200431.12.2008Pärt PetersonTartu Ülikool581 399,98 EUR
1.1.5.2.1.20.RARFSTIPPSiirdeuuringud neuroimmunoloogiliste haiguste paremaks diagnostikaks ja raviks07.07.200831.08.2015Eero VasarTartu Ülikool4 966 254,65 EUR
2.2.1.VMVBS17420T-rakkude regulatoorsed võrgustikud autoimmuunsetes haigustes04.09.201703.09.2019Pärt PetersonTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut16 248,00 EUR
SFSF0180021s07Tolerantsuse mehhanismid tüümuses01.01.200731.12.2012Pärt PetersonTartu Ülikool, Arstiteaduskond527 814,01 EUR
PRGPRG377Tsentraalne immuuntolerantsus01.01.201931.12.2023Pärt PetersonTartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut200 000,00 EUR
APIUT2-2AP14Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema IUT2-2 raames01.01.201431.10.2015Pärt PetersonTartu Ülikool, Arstiteaduskond61 750,00 EUR
APIUT2-2AP13Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema IUT2-2 raames01.01.201331.12.2014Pärt PetersonTartu Ülikool, Arstiteaduskond62 225,00 EUR
APSF0180021s07APVäikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180021s07 raames01.01.201031.12.2011Pärt PetersonTartu Ülikool, Arstiteaduskond44 322,73 EUR
APSF0180021s07AP11Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180021s07 raames01.01.201131.12.2012Pärt PetersonTartu Ülikool, Arstiteaduskond63 911,65 EUR