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Priit Palta

https://www.etis.ee/CV/Priit_Palta/eng
priit.palta@ut.ee

Career

Institutions and positions
2017–...   
Institute for Molecular Medicine Finland FIMM, University of Helsinki, Sequencing Informatics Team Lead (1,00)
01.02.2020–31.12.2020   
University of Tartu, Institute of Genomics, Senior Research Fellow of Genome Informatics (0,25)
01.01.2018–31.01.2020   
University of Tartu, Institute of Genomics, Research Fellow (0,25)
01.05.2016–31.12.2017   
University of Tartu, Estonian Genome Center , Research Fellow (0,25)
01.01.2016–30.04.2016   
University of Tartu, Estonian Genome Center , Specialist (0,20)
2013–2017   
Institute for Molecular Medicine Finland FIMM, University of Helsinki, post-doctoral fellow (1,00)
01.05.2011–30.09.2013   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow in Bioinformatics (0,50)
2011–2013   
Wellcome Trust Sanger Institute, Cambridge, UK, post-doctoral fellow (1,00)
01.05.2008–30.04.2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow (0,50)
01.01.2008–30.04.2008   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Programmer (0,50)
03.01.2005–31.12.2007   
Estonian Biocentre, Specialist (0,50)
2004–2008   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Chair of Bioinformatics, Other staff (0,50)
 
 
Education
2007–2015   
University of Tartu (Ph.D. in bioinformatics)
2005–2007   
University of Tartu (M.Sc. in bioinformatics)
2000–2005   
University of Tartu (B.Sc. in bioinformatics)
 
 
R&D related managerial and administrative work
2018−...   
Member of the Nordic Society for Precision Medicine
2012−...   
Member of the International Headache Society
2007−...   
Member of Estonian Society of Human Genetics

Qualifications

Academic degrees
Priit Palta, Doctor's Degree, 2015, (sup) Maido Remm, Computational methods for DNA copy number detection, University of Tartu.
Priit Palta, Research Master's Degree, 2007, (sup) Maido Remm, Statistical methods for DNA copy-number detection, University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology.
 
 
Honours & awards
2019, Priit Palta, Development of the NIPTIFY+ genetic testing platform, proof of concept and commercial feasibility; Enterprise Estonia
2018, Priit Palta, Genotype imputation-based polygenic risk score (PRS) platform, proof of concept and commercial feasibility; Business Finland funded TUTL award
2016, Priit Palta, Development of Nordic Exome Variant Catalogue, NIASC seed project Funding; Nordic Information for Action eScience Center, NordForsk
2013, Priit Palta, Finnish Cultural Foundation, personal research award
2007, Priit Palta, Estonian Genome Foundation – nominal scholarship of the Artur Lind's Stipend Foundation
2007, Priit Palta, Kristjan Jaak’s personal travel award
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS CLASSIFICATION: B110 Bioinformatics, medical informatics, biomathematics, biometrics
 
 
Additional information
Development of highly scalable statistical and computational methods for human genetics and genomics. Polygenic risk scores for complex diseases, statistical and deterministic computational haplotype phasing, genotype imputation, common and rare variant association testing. Population genetics and enriched variants in isolated populations, 2nd generation whole-exome sequencing (WES) and whole-genome sequencing (WGS) data processing and analysis.

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Supervision of postdoctoral researchers

  • 01.09.2016−...    Kalle Pärn  "Geeniandmete töötlemiseks ja analüüsimiseks vajalike suure läbilaskevõimega arvutuspilve-põhiste bioinformaatiliste töövoogude väljatöötamine" (University of Helsinki, Institute for Molecular Medicine Finland (FIMM))

Publications

Category
Year
Publication
 
1.1.
2021
Strausz, Satu; Ruotsalainen, Sanni; Ollila, Hanna M.; Karjalainen, Juha; Kiiskinen, Tuomo; Reeve, Mary; Kurki, Mitja; Mars, Nina; Havulinna, Aki S.; Luonsi, Elina; Aly, Dina Mansour; Ahlqvist, Emma; Teder-Laving, Maris; Palta, Priit; Groop, Leif; Magi, Reedik; Makitie, Antti; Salomaa, Veikko; Bachour, Adel; Tuomi, Tiinamaija ... Ripatti, Samuli (2021). Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. European Respiratory Journal, 57 (5), ARTN 2003091. DOI: 10.1183/13993003.03091-2020.
1.1.
2021
Paluoja, Priit; Teder, Hindrek; Ardeshirdavani, Amin; Bayindir, Baran; Vermeesch, Joris; Salumets, Andres; Krjutškov, Kaarel; Palta, Priit (2021). Systematic evaluation of NIPT aneuploidy detection software tools with clinically validated NIPT samples. PLoS Computational Biology, 17 (12), e1009684. DOI: 10.1371/journal.pcbi.1009684.
1.1.
2019
Teder, Hindrek; Paluoja, Priit; Rekker, Kadri; Salumets, Andres; Krjutskov, Kaarel; Palta, Priit (2019). Computational framework for targeted high coverage sequencing based NIPT Computational framework for targeted high coverage sequencing based NIPT. PLoS ONE, 14 (7), ARTN e0209139. DOI: 10.1371/journal.pone.0209139.
1.1.
2019
Žilina, Olga; Rekker, Kadri; Kaplinski, Lauris; Sauk, Martin; Paluoja, Priit; Teder, Hindrek; Ustav, Eva-Liina; Tõnisson, Neeme; Reimand, Tiia; Ridnoi, Konstantin; Palta, Priit; Vermeesch, Joris Robert; Krjutškov, Kaarel; Kurg, Ants; Salumets, Andres (2019). Creating basis for introducing non-invasive prenatal testing in the Estonian public health setting. Prenatal Diagnosis, 39 (13), 1262−1268. DOI: 10.1002/pd.5578.
1.1.
2019
Ripatti, Pietari; Soderlund, Sanni; Ramo, Joel T.; Surakka, Ida; Havulinna, Aki S.; Widen, Elisabeth; Palta, Priit; Freimer, Nelson B.; Salomaa, Veikko; Pirinen, Matti; Palotie, Aarno; Taskinen, Marja-Riitta; Ripatti, Samuli; (2019). Polygenic hyperlipidemias and coronary artery disease risk. Journal of the American College of Cardiology, 73, 1690. DOI: 10.1016/S0735-1097(19)32296-X.
1.1.
2019
Tabassum, Rubina; Rämö, Joel T.; Ripatti, Pietari; Koskela, Jukka T.; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T. J.; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J.; Surma, Michal A.; Klose, Christian; Stitziel, Nathan O.; Laivuori, Hannele; Havulinna, Aki S.; Service, Susan K.; Salomaa, Veikko ... (2019). Genetic architecture of human plasma lipidome and its link to cardiovascular disease. Nature Communications, 10, 4329. DOI: 10.1038/s41467-019-11954-8.
5.1.
2019
Tabassum, R.; Rämö, J.T.; Ripatti, P.; Koskela, J.T.; Kurki, M.; Karjalainen, J.; Palta, P.; Hassan, S.; Nunez-Fontarnau, J.; Kiiskinen, T.T.J.; Söderlund, S.; Matikainen, N.; Gerl, M.J.; Surma, M.A.; Klose, C.; Stitziel, N.O.; Laivuori, H.; Havulinna, A.S.; Service, S.K.; Salomaa, V. ... (2019). Genetics of human plasma lipidome and its link to diseases susceptibility. Atherosclerosis, 287, e14−e15. DOI: 10.1016/j.atherosclerosis.2019.06.040.
5.1.
2019
Ripatti, P.; Rämö, J.T.; Söderlund, S.; Surakka, I.; Havulinna, A.S.; Widén, E.; Palta, P.; Freimer, N.B.; Salomaa, V.; Pirinen, M.; Palotie, A.; Taskinen, M.R.; Ripatti, S.; (2019). Polygenic Hyperlipidemia Increases Coronary Artery Disease Risk In The Uk Biobank. Atherosclerosis, 287, e92. DOI: 10.1016/j.atherosclerosis.2019.06.266.
6.7.
2019
Kals, Mart; Nikopensius, Tiit; Läll, Kristi; Pärn, Kalle; Tõnis Sikka, Timo; Suvisaari, Jaana; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Metspalu, Andres; Esko, Tõnu; Palta, Priit; Mägi, Reedik; (2019). Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses. bioRxiv, 579201. DOI: 10.1101/579201.
6.8.
2019
Saare, Merli; Laisk, Triin; Teder, Hindrek; Paluoja, Priit; Palta, Priit; Koel, Mariann; Kirss, Fred; Karro, Helle; Soritsa, Deniss; Salumets, Andres; Krjutškov, Kaarel; Peters, Maire (2019). A molecular tool for menstrual cycle phase dating of endometrial samples in endometriosis transcriptome studies. Biology of Reproduction, 101 (1), 1−3. DOI: 10.1093/biolre/ioz072.
1.1.
2018
Winsvold, Bendik S; Palta, Priit; Eising, Else; Page, Christian M; van den Maagdenberg, Arn MJM; Palotie, Aarno; Zwart, John-Anker; (2018). Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study. Cephalalgia, 38 (2), 0333102417690111.10.1177/0333102417690111.
1.1.
2018
Huckins, L M; Hatzikotoulas, K; Southam, L; Thornton, L M; Steinberg, J; Aguilera-McKay, F; Treasure, J; Schmidt, U; Gunasinghe, C; Romero, A; Curtis, C; Rhodes, D; Moens, J; Kalsi, G; Dempster, D; Leung, R; Keohane, A; Burghardt, R; Ehrlich, S; Hebebrand, J ... (2018). Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa. Molecular Psychiatry, 23, 1169−1180.10.1038/mp.2017.88.
1.1.
2018
Sauk, M.; Žilina, O.; Kurg, A.; Ustav, E-L.; Peters, M.; Paluoja, P.; Roost, A.M.; Teder, H.; Palta, P.; Brison, N.; Vermeesch, J.R.; Krjutškov, K.; Salumets, A; Kaplinski, L. (2018). NIPTmer: rapid k-mer-based software package for detection of fetal aneuploidies. Scientific Reports. DOI: 10.1038/s41598-018-23589-8.
1.1.
2018
Teder, Hindrek; Koel, Mariann; Paluoja, Priit; Jatsenko, Tatjana; Rekker, Kadri; Laisk-Podar, Triin; Kukuškina, Viktorija; Velthut-Meikas, Agne; Fjodorova, Olga; Peters, Maire; Kere, Juha; Salumets, Andres; Palta, Priit; Krjutškov, Kaarel (2018). TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting. npj Genomic Medicine, 3, ARTN 34. DOI: 10.1038/s41525-018-0072-5.
1.1.
2018
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina; Falcone, Guido J.; Gormley, Padhraig; Malik, Rainer; Patsopoulos, Nikolaos A.; Ripke, Stephan; Wei, Zhi; Yu, Dongmei; Lee, Phil H.; Turley, Patrick; Grenier-Boley, Benjamin; Chouraki, Vincent; Kamatani, Yoichiro; Berr, Claudine ... (2018). Analysis of shared heritability in common disorders of the brain. Science, 360 (6395). DOI: 10.1126/science.aap8757.
1.1.
2018
Gormley, Padhraig; Kurki, Mitja I.; Hiekkala, Marjo Eveliina; Veerapen, Kumar; Häppölä, Paavo; Mitchell, Adele A.; Lal, Dennis; Palta, Priit; Surakka, Ida; Kaunisto, Mari Anneli; Hämäläinen, Eija; Vepsäläinen, Salli; Havanka, Hannele; Harno, Hanna; Ilmavirta, Matti; Nissilä, Markku; Säkö, Erkki; Sumelahti, Marja-Liisa; Liukkonen, Jarmo; Sillanpää, Matti ... (2018). Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron, 98 (4), 743−753.10.1016/j.neuron.2018.04.014.
1.1.
2018
Yang, Yuanhao; Zhao, Huiying; Boomsma, Dorret I.; Ligthart, Lannie; Belin, Andrea C.; Smith, George Davey; Esko, Tonu; Freilinger, Tobias M.; Hansen, Thomas Folkmann; Ikram, M. Arfan; Kallela, Mikko; Kubisch, Christian; Paraskevi, Christofidou; Strachan, David P.; Wessman, Maija; Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S.; Palta, Priit; Esko, Tonu ... (2018). Molecular genetic overlap between migraine and major depressive disorder. European Journal of Human Genetics, 26, 1202−1216. DOI: 10.1038/s41431-018-0150-2.
3.1.
2018
K. Pärn; M. Pirinen; M. Kals; R. Mägi; V. Salomaa; M. Boehnke; I. Hall; N. Stitziel; N. Freimer; M. Daly; A. Palotie; S. Ripatti; P. Palta; (2018). Differences in the Commonly used Genotype Imputation Algorithms and Their Imputation Accuracy Estimates. In: 2018 IEEE 14th International Conference on e-Science (e-Science) (293−294). IEEE. DOI: 10.1109/eScience.2018.00058.
5.2.
2018
Rekker, K.; Fjodorova, O.; Teder, H.; Paluoja, P.; Palta, P.; Ustav, E-L.; Ridnõi, K.; Kurg, A.; Kaplinski, L.; Krjutškov, K.; Salumets, A. (2018). NIPT – suure tundlikkusega meetod loote kromosoomhaiguste varajaseks tuvastamiseks. Eesti Arst, 97(Lisa 2): Tartu Ülikooli arstiteaduskonna aastapäeva teaduskonverents 2018; Tartu; 11.-12. okt. 2018. OÜ Celsius Healthcare, 37.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences, 114 (3), E327−E336. DOI: 10.1073/pnas.1619052114.
1.1.
2017
Mitt, Mario; Kals, Mart; Parn, Kalle; Gabriel, Stacey B; Lander, Eric S; Palotie, Aarno; Ripatti, Samuli; Morris, Andrew P; Metspalu, Andres; Esko, Tonu; Magi, Reedik; Palta, Priit; (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. European Journal of Human Genetics, 25 (7), 869−879. DOI: 10.1038/ejhg.2017.51.
1.1.
2017
Chheda, Himanshu; Palta, Priit; Pirinen, Matti; McCarthy, Shane; Walter, Klaudia; Koskinen, Seppo; Salomaa, Veikko; Daly, Mark; Durbin, Richard; Palotie, Aarno; Aittokallio, Tero; Ripatti, Samuli; (2017). Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom. European Journal of Human Genetics, 25, 477−484.10.1038/ejhg.2016.205.
1.1.
2017
Xue, Yali; Mezzavilla, Massimo; Haber, Marc; McCarthy, Shane; Chen, Yuan; Narasimhan, Vagheesh; Gilly, Arthur; Ayub, Qasim; Colonna, Vincenza; Southam, Lorraine; Finan, Christopher; Massaia, Andrea; Chheda, Himanshu; Palta, Priit; Ritchie, Graham; Asimit, Jennifer; Dedoussis, George; Gasparini, Paolo; Palotie, Aarno; Ripatti, Samuli ... Zeggini, Eleftheria (2017). Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations. Nature Communications, 8, ARTN 15927.10.1038/ncomms15927.
1.1.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8), 856−866. DOI: 10.1038/ng.3598.
6.8.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno. (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (10), 1296−1296. DOI: doi.org/10.1038/ng1016-1296c.
1.1.
2015
Palta, Priit; Kaplinski, Lauris; Nagirnaja, Liina; Veidenberg, Andres; Möls, Märt; Nelis, Mari; Esko, Tõnu; Metspalu, Andres; Laan, Maris; Remm, Maido (2015). Haplotype phasing and inheritance of copy number variants in nuclear families. PLoS ONE, 10 (4), UNSP e0122713. DOI: 10.1371/journal.pone.0122713.
1.1.
2014
Lim, ET.; Würtz, Peter; Havulinna, AS.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, RM.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina ... SISu, Project (2014). Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. PLoS Genetics, 10 (7), e1004494. DOI: 10.1371/journal.pgen.1004494.
1.1.
2014
Nagirnaja, Liina; Palta, Priit; Kasak, Laura; Rull, Kristiina; Christiansen, Ole B.; Nielsen, Henriette S.; Steffensen, Rudi; Esko, Tõnu; Remm, Maido; Laan, Maris (2014). Structural genomic variation as risk factor for idiopathic recurrent miscarriage. Human Mutation, 35 (8), 972−982. DOI: 10.1002/humu.22589.
1.1.
2014
Fromer, M.; Pocklington, Andrew J.; Kavanagh, David H.; Williams, Hywel J.; Dwyer, Sarah; Gormley, Padhraig; Georgieva, Lyudmila; Rees, Elliott; Palta, Priit; Ruderfer, Douglas M.; Carrera, Noa; Humphreys, Isla; Johnson, Jessica S.; Roussos, Panos; Barker, Douglas D.; Banks, Eric; Milanova, Vihra; Grant, Seth G.; Hannon, Eilis; Rose, Samuel A. ... O/'Donovan, Michael C. (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506 (7487), 179.10.1038/nature12929.
1.1.
2013
Zilbauer, Matthias; Rayner, Tim F.; Clark, Christine; Coffey, Alison J.; Joyce, Chris J.; Palta, Priit; Palotie, Aarno; Lyons, Paul A.; Smith, Kenneth G. C. (2013). Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type €“specific hypomethylated regions. Blood, 122 (25), e52 −e60 .10.1182/blood-2013-05-503201.
1.1.
2013
Anttila, Verneri; Winsvold, Bendik S; Gormley, Padhraig; Kurth, Tobias; Bettella, Francesco; McMahon, George; Kallela, Mikko; Malik, Rainer; de Vries, Boukje; Terwindt, Gisela; Medland, Sarah E; Todt, Unda; McArdle, Wendy L; Quaye, Lydia; Koiranen, Markku; Ikram, M Arfan; Lehtimaki, Terho; Stam, Anine H; Ligthart, Lannie; Wedenoja, Juho ... Palotie, Aarno (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45 (8), 912−917.10.1038/ng.2676.
1.1.
2012
Freilinger, Tobias; Anttila, Verneri; de Vries, Boukje; Malik, Rainer; Kallela, Mikko; Terwindt, Gisela M; Pozo-Rosich, Patricia; Winsvold, Bendik; Nyholt, Dale R; van Oosterhout, Willebrordus P J; Artto, Ville; Todt, Unda; Hamalainen, Eija; Fernandez-Morales, Jessica; Louter, Mark A; Kaunisto, Mari A; Schoenen, Jean; Raitakari, Olli; Lehtimaki, Terho; Vila-Pueyo, Marta ... International Headache, Genetics Consortium (2012). Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nature Genetics, 44 (7), 777−782.10.1038/ng.2307.
1.1.
2012
Clark, Christine; Palta, Priit; Joyce, Christopher J.; Scott, Carol; Grundberg, Elin; Deloukas, Panos; Palotie, Aarno; Coffey, Alison J. (2012). A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip® for Methylome Profiling. PLoS ONE, 7 (11), e50233.10.1371/journal.pone.0050233.
1.1.
2012
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; D'Hooghe, Thomas; Peters, Maire (2012). No evidence of somatic DNA copy number alterations in eutopic and ectopic endometrial tissue in endometriosis. Human Reproduction, 27 (6), 1857−1864. DOI: 10.1093/humrep/des125.
1.1.
2011
Scheler, O.; Kaplinski, L.; Glynn, B.; Palta, P.; Parkel, S.; Toome, K.; Maher, M.; Barry, T.; Remm, M.; Kurg, A. (2011). Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes. BMC Biotechnology, 11, 11−17. DOI: 10.1186/1472-6750-11-17.
1.1.
2011
Coffey, AJ.; Kokocinski, F.; Calafato, MS.; Scott, CE.; Palta, P.; Drury, E.; Joyce, CJ.; Leproust, EM.; Harrow, J.; Hunt, S.; Lehesjoki, AE.; Turner, DJ.; Hubbard, TJ.; Palotie, A. (2011). The GENCODE exome: sequencing the complete human exome. European Journal of Human Genetics, 19 (7), 827−831.10.1038/ejhg.2011.28.
1.1.
2011
Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
5.1.
2011
Nagirnaja, L.; Kasak, L.; Palta, P.; Rull, K.; Christiansen, OB.; Esko, T.; Remm, M.; Metspalu, A.; Laan, M. (2011). DNA copy number variations in recurrent miscarriage. Placenta: International Federation of Placenta Associations - 14th European Placenta Group Meeting 2011 14.-17. 09.2011 Geilo, Norra. Elsevier Ireland Ltd, A140−A140. (32; 9).
5.1.
2011
Saare, Merli; Sõritsa, Deniss; Järva, Liis; Vaidla, Kadri; Palta, Priit; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Detection of Genomic alterations in endometriosis using high-density SNP-arrays. 26: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 3-6 juuli, Stockholm, Rootsi. Oxford University Press, 213−214. (1).
5.1.
2011
Nagirnaja, L.; Kasak, L.; Palta, P.; Rull, K.; Christiansen, O.B.; Esko, T.; Remm, M.; Metspalu, A.; Laan, M. (2011). Role of DNA copy number variations in genetic predisposition to recurrent pregnancy loss. Journal of Reproductive Immunology, 90: 9th Congress of the European Society for Reproductive Immunology and European Society for Human Reproduction and Embryology Early Pregnancy Special Interest Group; Copenhagen, Denmark; August 23-26, 2011. UK: Elsevier Ireland Ltd, 145. (2). DOI: 10.1016/j.jri.2011.06.028.
5.2.
2011
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Genomic alterations in Endometriosis. European Human Genetics Conference 2011, 28 - 31 Mai , Amsterdam, Holland. , 159.
5.2.
2011
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). High-density snp-array analysis- no evidence of genomic alterations in endometriosis patients. 11th World Congress on Endometriosis, 4-7 september 2011, Montpellier, Prantsusmaa. , 91−92.
1.1.
2010
Kaplinski, L.; Scheler, O.; Parkel, S.; Palta, P.; Toome, K.; Kurg, A.; Remm, M. (2010). Detection of tmRNA molecules on microarrays at low temperatures using helper oligonucleotides. BMC Biotechnology, 10 (34), 1−10. DOI: 10.1186/1472-6750-10-34.
1.1.
2010
Walters, R. G.; Jacquemont, S.; Valsesia, A.; de Smith, A. J.; Martinet, D.; Andersson, J.; Falchi, M.; Chen, F.; Andrieux, J.; Lobbens, S.; Delobel, B.; Stutzmann, F.; El-Sayed Moustafa, J. S.; Chèvre, J.-C.; Lecoeur, C.; Vatin, V.; Bouquillon, S.; Buxton, J. L.; Boute, O.; Holder-Espinasse, M. ... Beckmann, J. S. (2010). A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature, 463 (7281), 671−675. DOI: 10.1038/nature08727.
1.1.
2010
Viltrop, T.; Krjutškov, K.; Palta, P.; Metspalu, A. (2010). Comparison of DNA extraction methods for multiplex PCR. Analytical Biochemistry, 398 (2), 260−262. DOI: 10.1016/j.ab.2009.11.026.
1.1.
2009
Scheler, O.; Glynn, B.; Parkel, S.; Palta, P.; Toome, K.; Kaplinski, L.; Remm, M.; Maher, M.; Kurg, A. (2009). Fluorescent labeling of NASBA amplified tmRNA molecules for microarray applications. BMC Biotechnology, 15 (9), 45−50. DOI: 10.1186/1472-6750-9-45.
1.1.
2009
Krjutškov, Kaarel; Viltrop, Triin; Palta, Priit; Metspalu, Ene; Tamm, Erika; Suvi, Siim; Sak, Katrin; Merilo, Alo; Sork, Helena; Teek, Rita; Nikopensius, Tiit; Kivisild, Toomas; Metspalu, Andres (2009). Evaluation of the 124-plex SNP typing microarray for forensic testing. Forensic Science International, 4 (1), 43−48. DOI: 10.1016/j.fsigen.2009.04.007.
5.1.
2009
Vooder, T., Välk, K., Palta ,P., Kolde, R., Metspalu, A. (2009). Parallel comparison of NSCLC CNV, survival and gene expression profiles in Estonian population. Journal of Thoracic Oncology: 13 th World Conference on Lung Cancer; San Francisco, USA; 31.07-04.08.2009. Lippincott Williams & Wilkins, 932−932. (Supplement: Suppl. 1).
5.1.
2009
Männik, K.; Žilina, O.; Parkel, S.; Palta, P.; Puusepp, H.; Veidenberg, A; Õunap, K;, Kurg, A. (2009). Genomic aberrations in relation to unexplained mental retardation in Estonian patients. European Journal of Human Genetics, 17: European Human Genetics Conference, Vienna Austria, May 23-26, 2009. , 69. (Suppl. 2).
1.1.
2008
Kousoulidou, L.; Männik, K.; Zilina, O.; Parkel, S.; Palta, P.; Remm, M.; Kurg, A.; Patsalis, P.C. (2008). Application of two different microarray-based copy-number detection methodologies - array-comparative genomic hybridization and array-multiplex amplifiable probe hybridization - with identical amplifiable target sequences. Clinical Chemistry and Laboratory Medicine (CCLM), 46 (5), 722−724.
1.1.
2008
Kousoulidou, L.; Männik, K.; Sismani, C.; Zilina, O.; Parkel, S.; Puusepp, H.; Tõnisson, N.; Palta, P.; Remm, M.; Kurg, A.; Patsalis, P. C. (2008). Array-MAPH: a methodology for the detection of locus copy-number changes in complex genomes. Nature Protocols, 3 (5), 849−865. DOI: 10.1038/nprot.2008.49.
5.1.
2008
Männik, K.; Palta, P.; Puusepp, H.; Žilina, O.; Parkel, S.; Veidenberg, A.; Õunap, K.; Kurg, A. (2008). Detection of genomic copy-number variation in estonian patients with unexplained familial mental retardation. Cellular Oncology, 30 (3), 264−264.
5.1.
2008
Glynn, B.; Lacey, K.; Palta, P.; Kaplinski, L.; Remm, M.; Barry, T.; Smith, T.; Maher, M. (2008). Demonstration of the application of the tmRNA transcript of the bacterial ssrA gene as a molecular diagnostic target using a combination of NASBA and BiaCore technologies. International Journal of Antimicrobial Agents, 29, S392.
5.1.
2008
Palta, P.; Parkel, S.; Veidenberg, A.; Mannik, K.; Puusepp, H.; Zilina, O.; Kurg, A.; Remm, M. (2008). Web-based database platform for large-scale copy number variation studies. Cellular Oncology, 30 (3), 270.
5.2.
2008
Zilina, O.; Männik, K.; Puusepp, H.; Parkel, S.; Palta, P.; Õunap, K.; Kurg, A. (2008). Detection of genomic copy number changes in Estonian patients with idiopathic mental retardation. European Journal of Human Genetics: European Human Genetics Conference; Barcelona; 31 mai-3 juuni 2008. Nature Publishing Group, 128. (16).
1.1.
2007
Kousoulidou, L.; Parkel, S.; Zilina, O.; Palta, P.; Puusepp, H.; Remm, M.; Turner, G.; Boyle, J.; van Bokhoven, H.; de Brouwer, A.; Van Esch, H.; Froyen, G.; Ropers, H.-H.; Chelly, J.; Moraine, C.; Gecz, J.; Kurg, A.; Patsalis, P. (2007). Screening of 20 patients with X-linked mental retardation using chromosome X–specific array-MAPH. European Journal of Medical Genetics, 50 (6), 399−410.
1.1.
2007
Patsalis, P.C.; Kousoulidou, L.; Männik, K.; Sismani, C.; Žilina, O.; Parkel, S.; Puusepp, H.; Tõnisson, N.; Palta, P.; Remm, M.; Kurg, A. (2007). Detection of small genomic imbalances using microarray-based multiplex amplifiable probe hybridization. European Journal of Human Genetics, 15 (2), 162−172. DOI: 10.1038/sj.ejhg.5201738.
21.12.2021

Priit Palta

https://www.etis.ee/CV/Priit_Palta/est
priit.palta@ut.ee

Teenistuskäik

Töökohad ja ametid
2017–...   
Institute for Molecular Medicine Finland FIMM, University of Helsinki, FinnGeni Sekveneerimise Informaatika tiimi juht (1,00)
01.02.2020–31.12.2020   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, genoomiinformaatika vanemteadur (0,25)
01.01.2018–31.01.2020   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, bioinformaatika ja genoomika teadur (0,25)
01.05.2016–31.12.2017   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, bioinformaatika ja genoomika teadur (0,25)
01.01.2016–30.04.2016   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, spetsialist (0,20)
2013–2017   
Institute for Molecular Medicine Finland FIMM, University of Helsinki, Järeldoktor (1,00)
01.05.2011–30.09.2013   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, bioinformaatika teadur (0,50)
2011–2013   
Wellcome Trust Sanger Institute, Cambridge, UK, Järeldoktor (1,00)
01.05.2008–30.04.2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, teadur (0,50)
01.01.2008–30.04.2008   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, programmeerija (0,50)
03.01.2005–31.12.2007   
Eesti Biokeskus, Bioinformaatika spetsialist (0,50)
2004–2008   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, Bioinformaatika õppetool, programmeerija (0,50)
 
 
Haridustee
2007–2015   
Tartu Ülikool (Ph.D. bioinformaatikas)
2005–2007   
Tartu Ülikool (M.Sc. bioinformaatikas)
2000–2005   
Tartu Ülikool (B.Sc. bioinformaatikas)
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2018−...   
Nordic Society for Precision Medicine liige
2012−...   
International Headache Society liige
2007−...   
Eesti Inimesegeneetika Ühingu liige

Kvalifikatsioon

Teaduskraadid
Priit Palta, Doctor's Degree, 2015, (sup) Maido Remm, Computational methods for DNA copy number detection, University of Tartu.
Priit Palta, Research Master's Degree, 2007, (sup) Maido Remm, Statistical methods for DNA copy-number detection, University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology.
 
 
Teaduspreemiad ja tunnustused
2019, Priit Palta, Development of the NIPTIFY+ genetic testing platform, proof of concept and commercial feasibility; Enterprise Estonia
2018, Priit Palta, Genotype imputation-based polygenic risk score (PRS) platform, proof of concept and commercial feasibility; Business Finland funded TUTL award
2016, Priit Palta, Development of Nordic Exome Variant Catalogue, NIASC seed project Funding; Nordic Information for Action eScience Center, NordForsk
2013, Priit Palta, Soome Kultuurifondi stipendium
2007, Priit Palta, SA Geenikeskus, Artur Linnu Stipendiumifond – Artur Linnu nimeline stipendium
2007, Priit Palta, Kristjan Jaagu personaalne teadusreiside rahastus
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS KLASSIFIKAATOR: B110 Bioinformaatika, meditsiiniinformaatika, biomatemaatika, biomeetrika
 
 
Lisainfo
Development of highly scalable statistical and computational methods for human genetics and genomics. Polygenic risk scores for complex diseases, statistical and deterministic computational haplotype phasing, genotype imputation, common and rare variant association testing. Population genetics and enriched variants in isolated populations, 2nd generation whole-exome sequencing (WES) and whole-genome sequencing (WGS) data processing and analysis.

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Juhendatud järeldoktorid

  • 01.09.2016−... Kalle Pärn "Geeniandmete töötlemiseks ja analüüsimiseks vajalike suure läbilaskevõimega arvutuspilve-põhiste bioinformaatiliste töövoogude väljatöötamine" Helsingi Ülikool, Soome Molekulaarse Meditsiini Instituut

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2021
Strausz, Satu; Ruotsalainen, Sanni; Ollila, Hanna M.; Karjalainen, Juha; Kiiskinen, Tuomo; Reeve, Mary; Kurki, Mitja; Mars, Nina; Havulinna, Aki S.; Luonsi, Elina; Aly, Dina Mansour; Ahlqvist, Emma; Teder-Laving, Maris; Palta, Priit; Groop, Leif; Magi, Reedik; Makitie, Antti; Salomaa, Veikko; Bachour, Adel; Tuomi, Tiinamaija ... Ripatti, Samuli (2021). Genetic analysis of obstructive sleep apnoea discovers a strong association with cardiometabolic health. European Respiratory Journal, 57 (5), ARTN 2003091. DOI: 10.1183/13993003.03091-2020.
1.1.
2021
Paluoja, Priit; Teder, Hindrek; Ardeshirdavani, Amin; Bayindir, Baran; Vermeesch, Joris; Salumets, Andres; Krjutškov, Kaarel; Palta, Priit (2021). Systematic evaluation of NIPT aneuploidy detection software tools with clinically validated NIPT samples. PLoS Computational Biology, 17 (12), e1009684. DOI: 10.1371/journal.pcbi.1009684.
1.1.
2019
Teder, Hindrek; Paluoja, Priit; Rekker, Kadri; Salumets, Andres; Krjutskov, Kaarel; Palta, Priit (2019). Computational framework for targeted high coverage sequencing based NIPT Computational framework for targeted high coverage sequencing based NIPT. PLoS ONE, 14 (7), ARTN e0209139. DOI: 10.1371/journal.pone.0209139.
1.1.
2019
Žilina, Olga; Rekker, Kadri; Kaplinski, Lauris; Sauk, Martin; Paluoja, Priit; Teder, Hindrek; Ustav, Eva-Liina; Tõnisson, Neeme; Reimand, Tiia; Ridnoi, Konstantin; Palta, Priit; Vermeesch, Joris Robert; Krjutškov, Kaarel; Kurg, Ants; Salumets, Andres (2019). Creating basis for introducing non-invasive prenatal testing in the Estonian public health setting. Prenatal Diagnosis, 39 (13), 1262−1268. DOI: 10.1002/pd.5578.
1.1.
2019
Ripatti, Pietari; Soderlund, Sanni; Ramo, Joel T.; Surakka, Ida; Havulinna, Aki S.; Widen, Elisabeth; Palta, Priit; Freimer, Nelson B.; Salomaa, Veikko; Pirinen, Matti; Palotie, Aarno; Taskinen, Marja-Riitta; Ripatti, Samuli; (2019). Polygenic hyperlipidemias and coronary artery disease risk. Journal of the American College of Cardiology, 73, 1690. DOI: 10.1016/S0735-1097(19)32296-X.
1.1.
2019
Tabassum, Rubina; Rämö, Joel T.; Ripatti, Pietari; Koskela, Jukka T.; Kurki, Mitja; Karjalainen, Juha; Palta, Priit; Hassan, Shabbeer; Nunez-Fontarnau, Javier; Kiiskinen, Tuomo T. J.; Söderlund, Sanni; Matikainen, Niina; Gerl, Mathias J.; Surma, Michal A.; Klose, Christian; Stitziel, Nathan O.; Laivuori, Hannele; Havulinna, Aki S.; Service, Susan K.; Salomaa, Veikko ... (2019). Genetic architecture of human plasma lipidome and its link to cardiovascular disease. Nature Communications, 10, 4329. DOI: 10.1038/s41467-019-11954-8.
5.1.
2019
Tabassum, R.; Rämö, J.T.; Ripatti, P.; Koskela, J.T.; Kurki, M.; Karjalainen, J.; Palta, P.; Hassan, S.; Nunez-Fontarnau, J.; Kiiskinen, T.T.J.; Söderlund, S.; Matikainen, N.; Gerl, M.J.; Surma, M.A.; Klose, C.; Stitziel, N.O.; Laivuori, H.; Havulinna, A.S.; Service, S.K.; Salomaa, V. ... (2019). Genetics of human plasma lipidome and its link to diseases susceptibility. Atherosclerosis, 287, e14−e15. DOI: 10.1016/j.atherosclerosis.2019.06.040.
5.1.
2019
Ripatti, P.; Rämö, J.T.; Söderlund, S.; Surakka, I.; Havulinna, A.S.; Widén, E.; Palta, P.; Freimer, N.B.; Salomaa, V.; Pirinen, M.; Palotie, A.; Taskinen, M.R.; Ripatti, S.; (2019). Polygenic Hyperlipidemia Increases Coronary Artery Disease Risk In The Uk Biobank. Atherosclerosis, 287, e92. DOI: 10.1016/j.atherosclerosis.2019.06.266.
6.7.
2019
Kals, Mart; Nikopensius, Tiit; Läll, Kristi; Pärn, Kalle; Tõnis Sikka, Timo; Suvisaari, Jaana; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Metspalu, Andres; Esko, Tõnu; Palta, Priit; Mägi, Reedik; (2019). Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses. bioRxiv, 579201. DOI: 10.1101/579201.
6.8.
2019
Saare, Merli; Laisk, Triin; Teder, Hindrek; Paluoja, Priit; Palta, Priit; Koel, Mariann; Kirss, Fred; Karro, Helle; Soritsa, Deniss; Salumets, Andres; Krjutškov, Kaarel; Peters, Maire (2019). A molecular tool for menstrual cycle phase dating of endometrial samples in endometriosis transcriptome studies. Biology of Reproduction, 101 (1), 1−3. DOI: 10.1093/biolre/ioz072.
1.1.
2018
Winsvold, Bendik S; Palta, Priit; Eising, Else; Page, Christian M; van den Maagdenberg, Arn MJM; Palotie, Aarno; Zwart, John-Anker; (2018). Epigenetic DNA methylation changes associated with headache chronification: A retrospective case-control study. Cephalalgia, 38 (2), 0333102417690111.10.1177/0333102417690111.
1.1.
2018
Huckins, L M; Hatzikotoulas, K; Southam, L; Thornton, L M; Steinberg, J; Aguilera-McKay, F; Treasure, J; Schmidt, U; Gunasinghe, C; Romero, A; Curtis, C; Rhodes, D; Moens, J; Kalsi, G; Dempster, D; Leung, R; Keohane, A; Burghardt, R; Ehrlich, S; Hebebrand, J ... (2018). Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa. Molecular Psychiatry, 23, 1169−1180.10.1038/mp.2017.88.
1.1.
2018
Sauk, M.; Žilina, O.; Kurg, A.; Ustav, E-L.; Peters, M.; Paluoja, P.; Roost, A.M.; Teder, H.; Palta, P.; Brison, N.; Vermeesch, J.R.; Krjutškov, K.; Salumets, A; Kaplinski, L. (2018). NIPTmer: rapid k-mer-based software package for detection of fetal aneuploidies. Scientific Reports. DOI: 10.1038/s41598-018-23589-8.
1.1.
2018
Teder, Hindrek; Koel, Mariann; Paluoja, Priit; Jatsenko, Tatjana; Rekker, Kadri; Laisk-Podar, Triin; Kukuškina, Viktorija; Velthut-Meikas, Agne; Fjodorova, Olga; Peters, Maire; Kere, Juha; Salumets, Andres; Palta, Priit; Krjutškov, Kaarel (2018). TAC-seq: targeted DNA and RNA sequencing for precise biomarker molecule counting. npj Genomic Medicine, 3, ARTN 34. DOI: 10.1038/s41525-018-0072-5.
1.1.
2018
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, Valentina; Falcone, Guido J.; Gormley, Padhraig; Malik, Rainer; Patsopoulos, Nikolaos A.; Ripke, Stephan; Wei, Zhi; Yu, Dongmei; Lee, Phil H.; Turley, Patrick; Grenier-Boley, Benjamin; Chouraki, Vincent; Kamatani, Yoichiro; Berr, Claudine ... (2018). Analysis of shared heritability in common disorders of the brain. Science, 360 (6395). DOI: 10.1126/science.aap8757.
1.1.
2018
Gormley, Padhraig; Kurki, Mitja I.; Hiekkala, Marjo Eveliina; Veerapen, Kumar; Häppölä, Paavo; Mitchell, Adele A.; Lal, Dennis; Palta, Priit; Surakka, Ida; Kaunisto, Mari Anneli; Hämäläinen, Eija; Vepsäläinen, Salli; Havanka, Hannele; Harno, Hanna; Ilmavirta, Matti; Nissilä, Markku; Säkö, Erkki; Sumelahti, Marja-Liisa; Liukkonen, Jarmo; Sillanpää, Matti ... (2018). Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. Neuron, 98 (4), 743−753.10.1016/j.neuron.2018.04.014.
1.1.
2018
Yang, Yuanhao; Zhao, Huiying; Boomsma, Dorret I.; Ligthart, Lannie; Belin, Andrea C.; Smith, George Davey; Esko, Tonu; Freilinger, Tobias M.; Hansen, Thomas Folkmann; Ikram, M. Arfan; Kallela, Mikko; Kubisch, Christian; Paraskevi, Christofidou; Strachan, David P.; Wessman, Maija; Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S.; Palta, Priit; Esko, Tonu ... (2018). Molecular genetic overlap between migraine and major depressive disorder. European Journal of Human Genetics, 26, 1202−1216. DOI: 10.1038/s41431-018-0150-2.
3.1.
2018
K. Pärn; M. Pirinen; M. Kals; R. Mägi; V. Salomaa; M. Boehnke; I. Hall; N. Stitziel; N. Freimer; M. Daly; A. Palotie; S. Ripatti; P. Palta; (2018). Differences in the Commonly used Genotype Imputation Algorithms and Their Imputation Accuracy Estimates. In: 2018 IEEE 14th International Conference on e-Science (e-Science) (293−294). IEEE. DOI: 10.1109/eScience.2018.00058.
5.2.
2018
Rekker, K.; Fjodorova, O.; Teder, H.; Paluoja, P.; Palta, P.; Ustav, E-L.; Ridnõi, K.; Kurg, A.; Kaplinski, L.; Krjutškov, K.; Salumets, A. (2018). NIPT – suure tundlikkusega meetod loote kromosoomhaiguste varajaseks tuvastamiseks. Eesti Arst, 97(Lisa 2): Tartu Ülikooli arstiteaduskonna aastapäeva teaduskonverents 2018; Tartu; 11.-12. okt. 2018. OÜ Celsius Healthcare, 37.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences, 114 (3), E327−E336. DOI: 10.1073/pnas.1619052114.
1.1.
2017
Mitt, Mario; Kals, Mart; Parn, Kalle; Gabriel, Stacey B; Lander, Eric S; Palotie, Aarno; Ripatti, Samuli; Morris, Andrew P; Metspalu, Andres; Esko, Tonu; Magi, Reedik; Palta, Priit; (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. European Journal of Human Genetics, 25 (7), 869−879. DOI: 10.1038/ejhg.2017.51.
1.1.
2017
Chheda, Himanshu; Palta, Priit; Pirinen, Matti; McCarthy, Shane; Walter, Klaudia; Koskinen, Seppo; Salomaa, Veikko; Daly, Mark; Durbin, Richard; Palotie, Aarno; Aittokallio, Tero; Ripatti, Samuli; (2017). Whole-genome view of the consequences of a population bottleneck using 2926 genome sequences from Finland and United Kingdom. European Journal of Human Genetics, 25, 477−484.10.1038/ejhg.2016.205.
1.1.
2017
Xue, Yali; Mezzavilla, Massimo; Haber, Marc; McCarthy, Shane; Chen, Yuan; Narasimhan, Vagheesh; Gilly, Arthur; Ayub, Qasim; Colonna, Vincenza; Southam, Lorraine; Finan, Christopher; Massaia, Andrea; Chheda, Himanshu; Palta, Priit; Ritchie, Graham; Asimit, Jennifer; Dedoussis, George; Gasparini, Paolo; Palotie, Aarno; Ripatti, Samuli ... Zeggini, Eleftheria (2017). Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations. Nature Communications, 8, ARTN 15927.10.1038/ncomms15927.
1.1.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8), 856−866. DOI: 10.1038/ng.3598.
6.8.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno. (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (10), 1296−1296. DOI: doi.org/10.1038/ng1016-1296c.
1.1.
2015
Palta, Priit; Kaplinski, Lauris; Nagirnaja, Liina; Veidenberg, Andres; Möls, Märt; Nelis, Mari; Esko, Tõnu; Metspalu, Andres; Laan, Maris; Remm, Maido (2015). Haplotype phasing and inheritance of copy number variants in nuclear families. PLoS ONE, 10 (4), UNSP e0122713. DOI: 10.1371/journal.pone.0122713.
1.1.
2014
Lim, ET.; Würtz, Peter; Havulinna, AS.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, RM.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina ... SISu, Project (2014). Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. PLoS Genetics, 10 (7), e1004494. DOI: 10.1371/journal.pgen.1004494.
1.1.
2014
Nagirnaja, Liina; Palta, Priit; Kasak, Laura; Rull, Kristiina; Christiansen, Ole B.; Nielsen, Henriette S.; Steffensen, Rudi; Esko, Tõnu; Remm, Maido; Laan, Maris (2014). Structural genomic variation as risk factor for idiopathic recurrent miscarriage. Human Mutation, 35 (8), 972−982. DOI: 10.1002/humu.22589.
1.1.
2014
Fromer, M.; Pocklington, Andrew J.; Kavanagh, David H.; Williams, Hywel J.; Dwyer, Sarah; Gormley, Padhraig; Georgieva, Lyudmila; Rees, Elliott; Palta, Priit; Ruderfer, Douglas M.; Carrera, Noa; Humphreys, Isla; Johnson, Jessica S.; Roussos, Panos; Barker, Douglas D.; Banks, Eric; Milanova, Vihra; Grant, Seth G.; Hannon, Eilis; Rose, Samuel A. ... O/'Donovan, Michael C. (2014). De novo mutations in schizophrenia implicate synaptic networks. Nature, 506 (7487), 179.10.1038/nature12929.
1.1.
2013
Zilbauer, Matthias; Rayner, Tim F.; Clark, Christine; Coffey, Alison J.; Joyce, Chris J.; Palta, Priit; Palotie, Aarno; Lyons, Paul A.; Smith, Kenneth G. C. (2013). Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type €“specific hypomethylated regions. Blood, 122 (25), e52 −e60 .10.1182/blood-2013-05-503201.
1.1.
2013
Anttila, Verneri; Winsvold, Bendik S; Gormley, Padhraig; Kurth, Tobias; Bettella, Francesco; McMahon, George; Kallela, Mikko; Malik, Rainer; de Vries, Boukje; Terwindt, Gisela; Medland, Sarah E; Todt, Unda; McArdle, Wendy L; Quaye, Lydia; Koiranen, Markku; Ikram, M Arfan; Lehtimaki, Terho; Stam, Anine H; Ligthart, Lannie; Wedenoja, Juho ... Palotie, Aarno (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45 (8), 912−917.10.1038/ng.2676.
1.1.
2012
Freilinger, Tobias; Anttila, Verneri; de Vries, Boukje; Malik, Rainer; Kallela, Mikko; Terwindt, Gisela M; Pozo-Rosich, Patricia; Winsvold, Bendik; Nyholt, Dale R; van Oosterhout, Willebrordus P J; Artto, Ville; Todt, Unda; Hamalainen, Eija; Fernandez-Morales, Jessica; Louter, Mark A; Kaunisto, Mari A; Schoenen, Jean; Raitakari, Olli; Lehtimaki, Terho; Vila-Pueyo, Marta ... International Headache, Genetics Consortium (2012). Genome-wide association analysis identifies susceptibility loci for migraine without aura. Nature Genetics, 44 (7), 777−782.10.1038/ng.2307.
1.1.
2012
Clark, Christine; Palta, Priit; Joyce, Christopher J.; Scott, Carol; Grundberg, Elin; Deloukas, Panos; Palotie, Aarno; Coffey, Alison J. (2012). A Comparison of the Whole Genome Approach of MeDIP-Seq to the Targeted Approach of the Infinium HumanMethylation450 BeadChip® for Methylome Profiling. PLoS ONE, 7 (11), e50233.10.1371/journal.pone.0050233.
1.1.
2012
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; D'Hooghe, Thomas; Peters, Maire (2012). No evidence of somatic DNA copy number alterations in eutopic and ectopic endometrial tissue in endometriosis. Human Reproduction, 27 (6), 1857−1864. DOI: 10.1093/humrep/des125.
1.1.
2011
Scheler, O.; Kaplinski, L.; Glynn, B.; Palta, P.; Parkel, S.; Toome, K.; Maher, M.; Barry, T.; Remm, M.; Kurg, A. (2011). Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes. BMC Biotechnology, 11, 11−17. DOI: 10.1186/1472-6750-11-17.
1.1.
2011
Coffey, AJ.; Kokocinski, F.; Calafato, MS.; Scott, CE.; Palta, P.; Drury, E.; Joyce, CJ.; Leproust, EM.; Harrow, J.; Hunt, S.; Lehesjoki, AE.; Turner, DJ.; Hubbard, TJ.; Palotie, A. (2011). The GENCODE exome: sequencing the complete human exome. European Journal of Human Genetics, 19 (7), 827−831.10.1038/ejhg.2011.28.
1.1.
2011
Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
5.1.
2011
Nagirnaja, L.; Kasak, L.; Palta, P.; Rull, K.; Christiansen, OB.; Esko, T.; Remm, M.; Metspalu, A.; Laan, M. (2011). DNA copy number variations in recurrent miscarriage. Placenta: International Federation of Placenta Associations - 14th European Placenta Group Meeting 2011 14.-17. 09.2011 Geilo, Norra. Elsevier Ireland Ltd, A140−A140. (32; 9).
5.1.
2011
Saare, Merli; Sõritsa, Deniss; Järva, Liis; Vaidla, Kadri; Palta, Priit; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Detection of Genomic alterations in endometriosis using high-density SNP-arrays. 26: 27th Annual Meeting of the European Society of Human Reproduction and Embryology, 3-6 juuli, Stockholm, Rootsi. Oxford University Press, 213−214. (1).
5.1.
2011
Nagirnaja, L.; Kasak, L.; Palta, P.; Rull, K.; Christiansen, O.B.; Esko, T.; Remm, M.; Metspalu, A.; Laan, M. (2011). Role of DNA copy number variations in genetic predisposition to recurrent pregnancy loss. Journal of Reproductive Immunology, 90: 9th Congress of the European Society for Reproductive Immunology and European Society for Human Reproduction and Embryology Early Pregnancy Special Interest Group; Copenhagen, Denmark; August 23-26, 2011. UK: Elsevier Ireland Ltd, 145. (2). DOI: 10.1016/j.jri.2011.06.028.
5.2.
2011
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). Genomic alterations in Endometriosis. European Human Genetics Conference 2011, 28 - 31 Mai , Amsterdam, Holland. , 159.
5.2.
2011
Saare, Merli; Sõritsa, Deniss; Vaidla, Kadri; Palta, Priit; Remm, Maido; Laan, Martti; Karro, Helle; Sõritsa, Andrei; Salumets, Andres; Peters, Maire. (2011). High-density snp-array analysis- no evidence of genomic alterations in endometriosis patients. 11th World Congress on Endometriosis, 4-7 september 2011, Montpellier, Prantsusmaa. , 91−92.
1.1.
2010
Kaplinski, L.; Scheler, O.; Parkel, S.; Palta, P.; Toome, K.; Kurg, A.; Remm, M. (2010). Detection of tmRNA molecules on microarrays at low temperatures using helper oligonucleotides. BMC Biotechnology, 10 (34), 1−10. DOI: 10.1186/1472-6750-10-34.
1.1.
2010
Walters, R. G.; Jacquemont, S.; Valsesia, A.; de Smith, A. J.; Martinet, D.; Andersson, J.; Falchi, M.; Chen, F.; Andrieux, J.; Lobbens, S.; Delobel, B.; Stutzmann, F.; El-Sayed Moustafa, J. S.; Chèvre, J.-C.; Lecoeur, C.; Vatin, V.; Bouquillon, S.; Buxton, J. L.; Boute, O.; Holder-Espinasse, M. ... Beckmann, J. S. (2010). A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature, 463 (7281), 671−675. DOI: 10.1038/nature08727.
1.1.
2010
Viltrop, T.; Krjutškov, K.; Palta, P.; Metspalu, A. (2010). Comparison of DNA extraction methods for multiplex PCR. Analytical Biochemistry, 398 (2), 260−262. DOI: 10.1016/j.ab.2009.11.026.
1.1.
2009
Scheler, O.; Glynn, B.; Parkel, S.; Palta, P.; Toome, K.; Kaplinski, L.; Remm, M.; Maher, M.; Kurg, A. (2009). Fluorescent labeling of NASBA amplified tmRNA molecules for microarray applications. BMC Biotechnology, 15 (9), 45−50. DOI: 10.1186/1472-6750-9-45.
1.1.
2009
Krjutškov, Kaarel; Viltrop, Triin; Palta, Priit; Metspalu, Ene; Tamm, Erika; Suvi, Siim; Sak, Katrin; Merilo, Alo; Sork, Helena; Teek, Rita; Nikopensius, Tiit; Kivisild, Toomas; Metspalu, Andres (2009). Evaluation of the 124-plex SNP typing microarray for forensic testing. Forensic Science International, 4 (1), 43−48. DOI: 10.1016/j.fsigen.2009.04.007.
5.1.
2009
Vooder, T., Välk, K., Palta ,P., Kolde, R., Metspalu, A. (2009). Parallel comparison of NSCLC CNV, survival and gene expression profiles in Estonian population. Journal of Thoracic Oncology: 13 th World Conference on Lung Cancer; San Francisco, USA; 31.07-04.08.2009. Lippincott Williams & Wilkins, 932−932. (Supplement: Suppl. 1).
5.1.
2009
Männik, K.; Žilina, O.; Parkel, S.; Palta, P.; Puusepp, H.; Veidenberg, A; Õunap, K;, Kurg, A. (2009). Genomic aberrations in relation to unexplained mental retardation in Estonian patients. European Journal of Human Genetics, 17: European Human Genetics Conference, Vienna Austria, May 23-26, 2009. , 69. (Suppl. 2).
1.1.
2008
Kousoulidou, L.; Männik, K.; Zilina, O.; Parkel, S.; Palta, P.; Remm, M.; Kurg, A.; Patsalis, P.C. (2008). Application of two different microarray-based copy-number detection methodologies - array-comparative genomic hybridization and array-multiplex amplifiable probe hybridization - with identical amplifiable target sequences. Clinical Chemistry and Laboratory Medicine (CCLM), 46 (5), 722−724.
1.1.
2008
Kousoulidou, L.; Männik, K.; Sismani, C.; Zilina, O.; Parkel, S.; Puusepp, H.; Tõnisson, N.; Palta, P.; Remm, M.; Kurg, A.; Patsalis, P. C. (2008). Array-MAPH: a methodology for the detection of locus copy-number changes in complex genomes. Nature Protocols, 3 (5), 849−865. DOI: 10.1038/nprot.2008.49.
5.1.
2008
Männik, K.; Palta, P.; Puusepp, H.; Žilina, O.; Parkel, S.; Veidenberg, A.; Õunap, K.; Kurg, A. (2008). Detection of genomic copy-number variation in estonian patients with unexplained familial mental retardation. Cellular Oncology, 30 (3), 264−264.
5.1.
2008
Glynn, B.; Lacey, K.; Palta, P.; Kaplinski, L.; Remm, M.; Barry, T.; Smith, T.; Maher, M. (2008). Demonstration of the application of the tmRNA transcript of the bacterial ssrA gene as a molecular diagnostic target using a combination of NASBA and BiaCore technologies. International Journal of Antimicrobial Agents, 29, S392.
5.1.
2008
Palta, P.; Parkel, S.; Veidenberg, A.; Mannik, K.; Puusepp, H.; Zilina, O.; Kurg, A.; Remm, M. (2008). Web-based database platform for large-scale copy number variation studies. Cellular Oncology, 30 (3), 270.
5.2.
2008
Zilina, O.; Männik, K.; Puusepp, H.; Parkel, S.; Palta, P.; Õunap, K.; Kurg, A. (2008). Detection of genomic copy number changes in Estonian patients with idiopathic mental retardation. European Journal of Human Genetics: European Human Genetics Conference; Barcelona; 31 mai-3 juuni 2008. Nature Publishing Group, 128. (16).
1.1.
2007
Kousoulidou, L.; Parkel, S.; Zilina, O.; Palta, P.; Puusepp, H.; Remm, M.; Turner, G.; Boyle, J.; van Bokhoven, H.; de Brouwer, A.; Van Esch, H.; Froyen, G.; Ropers, H.-H.; Chelly, J.; Moraine, C.; Gecz, J.; Kurg, A.; Patsalis, P. (2007). Screening of 20 patients with X-linked mental retardation using chromosome X–specific array-MAPH. European Journal of Medical Genetics, 50 (6), 399−410.
1.1.
2007
Patsalis, P.C.; Kousoulidou, L.; Männik, K.; Sismani, C.; Žilina, O.; Parkel, S.; Puusepp, H.; Tõnisson, N.; Palta, P.; Remm, M.; Kurg, A. (2007). Detection of small genomic imbalances using microarray-based multiplex amplifiable probe hybridization. European Journal of Human Genetics, 15 (2), 162−172. DOI: 10.1038/sj.ejhg.5201738.
21.12.2021

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ProgramTypeNumberNameProject startProject endPrincipal investigatorInstitutionFinancing
SFSF0180026s09Computational studies of genome sequences01.01.200931.12.2014Maido RemmUniversity of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu; University of Tartu, Faculty of Science and Technology (old)546 107,92 EUR
ETFETF7617DNA copy-number variations and human (X-linked) mental retardation01.01.200831.12.2011Ants KurgUniversity of Tartu, Faculty of Biology and Geography; University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu; University of Tartu, Faculty of Science and Technology (old)74 393,39 EUR
MUUVP1GI19575 FinnGen collaboration02.10.201931.10.2020Tõnu EskoUniversity of Tartu, Institute of Genomics240 000,00 EUR
TKSLTMR16142T (TK142)Centre of Excellence for Genomics and Translational Medicine (TK142)01.01.201601.03.2023Andres MetspaluUniversity of Tartu, Estonian Genome Center 4 474 349,50 EUR
SFSF0182649s04Haplotype structure of the human genome01.01.200431.12.2008Maido RemmUniversity of Tartu, Faculty of Biology and Geography224 329,88 EUR
MUUSLIC-513771 (LSHB-CT-2005-513771)SLIC-Biosensors in Molecular Diagnostics: Nanotechnology for the Analysis of species-specific Microbial Transcripts01.01.200531.12.2007Ants KurgEstonian Biocentre383 999,97 EUR
1.1.5.3.4.1.3.2.; 1.2.3.6.3.SP1GI20181T (MOBERA21)Investigating DETerminants of atrial Electrical ConducTion underlying ARRHYTHMIAS (ERA-CVD)01.04.202030.04.2022Tõnu EskoUniversity of Tartu, Institute of Genomics144 245,20 EUR
PRGPRG1291Sytematic phenome-wide search for genetic modulators in health and disease01.01.202131.12.2025Tõnu EskoUniversity of Tartu, Institute of Genomics475 750,00 EUR
ETFETF5467Development of novel DNA diagnostic technologies for the detection of structural chromosomal abnormalities in case of mental retardation01.01.200331.12.2006Ants KurgUniversity of Tartu, Faculty of Biology and Geography51 656,40 EUR