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Reedik Mägi

https://www.etis.ee/CV/Reedik_Mägi/est
18.08.1978
737 4045
reedik.magi@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2018–...   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, bioinformaatika vanemteadur (1,00)
01.09.2016–31.12.2017   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, bioinformaatika vanemteadur (1,00)
01.09.2011–31.08.2016   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, statistilise geneetika vanemteadur (1,00)
01.02.2010–31.08.2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, teadur (0,10)
2009–2011   
University Of Oxford, Marie Curie Research Fellow in Wellcome Trust Centre for Human Genetics (1,00)
01.09.2008–31.08.2011   
Eesti Biokeskus, Erakorraline teadur (0,10)
01.04.2008–31.01.2010   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, erakorraline teadur (0,10)
2008–2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, Bioinformaatika õppetool, Erakorraline teadur (0,10)
2008–2009   
University Of Oxford, Senior Statistical Geneticist (1,00)
01.01.2008–31.12.2011   
Wellcome Trust Centre for Human Genetics, Univeristy of Oxford; postdok
01.01.2008–31.03.2008   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, erakorraline teadur (1,00)
01.12.2007–31.12.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.08.2007–30.11.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,10)
01.02.2007–31.07.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.09.2006–31.01.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.07.2006–31.08.2006   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.09.2005–30.06.2006   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.07.2005–31.08.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.02.2005–30.06.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.02.2004–31.01.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
2004–2008   
Tartu Ülikool, Tartu Ülikool, erak. teadur (0,50)
01.01.2002–2004   
OÜ Biodata, OÜ Biodata, IT spetsialist (0,50)
01.01.2000–31.12.2002   
AS Asper Biotech, IT spetsialist
 
 
Haridustee
2003–2007   
Tartu Ülikool bioinformaatika eriala doktoriõpe
2000–2003   
Tartu Ülikool taimeökoloogia eriala magistriõpe
1996–2000   
Tartu Ülikool botaanika ja ökoloogia eriala bakalaureuseõpe
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2016−...   
Igaaastase kursuse "Introduction to the statistical analysis of genome-wide association studies" Imperial College of London, UK kaasjuht
2017−2017   
Konverentsi "European Mathematical Genetics Meeting" organiseerija ja teaduskomitee liige

Kvalifikatsioon

Teaduskraadid
Reedik Mägi, doktorikraad, 2007, (juh) Maido Remm, The Linkage Disequilibrium And The Selection of Genetic markers For Association Studies in European Populations, Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut.
Reedik Mägi, magistrikraad (teaduskraad), 2003, (juh) Kristjan Zobel, Rohu- ja puhmarinde võra struktuur 27 Eesti niidu- ja metsakoosluses, Tartu Ülikool, Bioloogia-geograafiateaduskond, Botaanika ja ökoloogia instituut.
 
 
Teaduspreemiad ja tunnustused
2019, Reedik Mägi, Riigi teaduspreemia keemia ja molekulaarbioloogia alal teadustöö „Geneetika- ja genoomikaalased alusuuringud personaalmeditsiini rakendamiseks Eestis“ eest (Esko, Mägi, Fischer, Milani)
2009, Reedik Mägi, EC FP7 Marie Curie IEF (2009-2011)
2008, Reedik Mägi, Järeldoktorantuuri grant Eesti Biokeskusest (ECOGENE)
 
 
Teadustöö põhisuunad
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin; CERCS ERIALA: B100 Biomeditsiini ajalugu ja filosoofia, teoreetiline bioloogia, evolutsiooni üldised küsimused ; PÕHISUUND: Main scientific interests include population and statistical genetics, as well as software development for implementing statistical methods for genetic studies. I have worked on the development and implementation of methodology of meta-analysis, rare-variant analysis, and sequencing data analysis. I am also participating in several association studies, which are mainly related to T2D and various anthropometric phenotypes.

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F; Feufer, Arne P; Marullo, Letizia; Mägi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in medicine.10.2217/bmm-2017-0431 [ilmumas].
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in medicine, 1−8.10.1038/s41436-018-0311-2 [ilmumas].
1.1.
2019
Reisberg, Sulev; Galwey, Nicholas; Avillach, Paul; Sahlqvist, Anna-Stina; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Vilo, Jaak; James, Glen (2019). Comparison of variation in frequency for SNPs associated with asthma or liver disease between Estonia, HapMap populations and the 1000 genome project populations. International Journal of Immunogenetics, 46 (1), 1−10.10.1111/iji.12413.
1.1.
2019
Tasa, T.; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 27 (3), 442−454.10.1038/s41431-018-0300-6.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, in press.10.1111/eva.12780 [ilmumas].
1.1.
2019
de Vries, Paul S; Brown, Michael R; Bentley, Amy R; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C (2019). Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology.10.1093/aje/kwz005 [ilmumas].
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648.10.1038/s41588-019-0378-y.
1.1.
2019
Saag, Lehti; Laneman, Margot; Varul, Liivi; Malve, Martin; Valk, Heiki; Razzak, Maria A.; Shirobokov, Ivan G.; Khartanovich, Valeri I.; Mikhaylova, Elena R.; Kushniarevich, Alena; Scheib, Christiana Lyn; Solnik, Anu; Reisberg, Tuuli; Parik, Jüri; Saag, Lauri; Metspalu, Ene; Rootsi, Siiri; Montinaro, Francesco; Remm, Maido; Mägi, Reedik ... Tambets, Kristiina (2019). The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers Further East. Current Biology [ilmumas].
1.1.
2019
Justice, Anne E; Karaderi, Tugce; Highland, Heather M; Young, Kristin L; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L; Fine, Rebecca S; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W; Locke, Adam E; Medina-Gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush ... Lindgren, Cecilia M (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51 (3), 452−469.10.1038/s41588-018-0334-2.
1.1.
2019
Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; ,; ,; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D ... Vrieze, Scott (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51 (2), 237−244.10.1038/s41588-018-0307-5.
1.1.
2019
Bovijn, Jonas; Jackson, Leigh; Censin, Jenny; Chen, Chia-Yen; Laisk, Triin; Laber, Samantha; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Smoller, Jordan W; Harrison, Jamie W; Ruth, Katherine S; Beaumont, Robin N; Jones, Samuel E; Tyrrell, Jessica; Wood, Andrew R; Weedon, Michael N; Mägi, Reedik; Neale, Benjamin; Lindgren, Cecilia M ... Holmes, Michael V (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104 (1), 157−163.10.1016/j.ajhg.2018.11.004.
1.1.
2019
Wiberg, Akira; Ng, Michael; Schmid, Annina B.; Smillie, Robert W.; Baskozos, Georgios; Holmes, Michael V.; Kunnapuu, K.; Magi, R.; Bennett, David L.; Furniss, Dominic (2019). A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nature Communications, 10, ARTN 1030.10.1038/s41467-019-08993-6.
1.1.
2019
James, Glen; Reisberg, Sulev; Lepik, Kaido; Galwey, Nicholas; Avillach, Paul; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Alexander, Myriam; Waterworth, Dawn; Loomis, A. Katrina; Vilo, Jaak (2019). An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank. PLoS ONE, 14 (4), e0215026.10.1371/journal.pone.0215026.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
1.1.
2018
Pervjakova, N.; Kukushkina, V.; Haller, T.; Kasela, S.; Joensuu, A.; Kristiansson, K.; Annilo, T.; Perola, M.; Salomaa, V.; Jousilahti, P.; Metspalu, A.; Magi, R. (2018). Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene. Biomarkers in medicine, 12 (5), 439−446.10.2217/bmm-2018-0020.
1.1.
2018
Suhorutshenko, Marina; Kukushkina, Viktorija; Velthut-Meikas, Agne; Altmäe, Signe; Peters, Maire; Mägi, Reedik; Krjutškov, Kaarel; Koel, Mariann; Codoñer, Francisco; Martinez-Blanch, Juan; Vilella, Felipe; Simón, Carlos; Salumets, Andres; Laisk, Triin (2018). Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. Human Reproduction, 33 (11), 2074−2086.10.1093/humrep/dey301.
1.1.
2018
Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
1.1.
2018
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
1.1.
2018
Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. Jornal Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
1.1.
2018
Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516.10.1038/s41588-018-0241-6.
1.1.
2018
Pasman, Joëlle A; Verweij, Karin J H; Gerring, Zachary; Stringer, Sven; Sanchez-Roige, Sandra; Treur, Jorien L; Abdellaoui, Abdel; Nivard, Michel G; Baselmans, Bart M L; Ong, Jue-Sheng; Ip, Hill F; van der Zee, Matthijs D; Bartels, Meike; Day, Felix R; Fontanillas, Pierre; Elson, Sarah L; ,; de Wit, Harriet; Davis, Lea K; MacKillop, James ... Vink, Jacqueline M (2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21 (9), 1161−1170.10.1038/s41593-018-0206-1.
1.1.
2018
Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429.10.1038/s41588-018-0205-x.
1.1.
2018
Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571.10.1038/s41588-018-0084-1.
3.1.
2018
Vals, M.A.; Pajusalu, S.; Kals, M.; Mägi, R.; Õunap, K. (2018). The Prevalence of PMM2-CDG in Estonia Based on Population Carrier Frequencies and Diagnosed Patients. JIMD Reports, 39, 13−17.10.1007/8904_2017_41.
6.8.
2018
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez ... McCarthy, Mark I (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5, 180002−180002.10.1038/sdata.2018.2.
6.8.
2018
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael ... Caulfield, Mark J (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (12), 1755−1755.10.1038/s41588-018-0297-3.
1.1.
2017
Huan, Tianxiao; Joehanes, Roby; Schurmann, Claudia; Schramm, Katharina; Pilling, Luke C; Peters, Marjolein J; Mägi, Reedik; DeMeo, Dawn; O'Connor, George T; Ferrucci, Luigi; Teumer, Alexander; Homuth, Georg; Biffar, Reiner; Völker, Uwe; Herder, Christian; Waldenberger, Melanie; Peters, Annette; Zeilinger, Sonja; Metspalu, Andres; Hofman, Albert ... Levy, Daniel (2017). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics, 25 (21), 1−33.10.1093/hmg/ddw288.
1.1.
2017
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201.10.1038/mp.2016.71.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 114 (3), E327−E336.10.1073/pnas.1619052114.
1.1.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 3, 403−415.10.1038/ng.3768.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110.10.1186/s12859-017-1530-2.
1.1.
2017
Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25.10.1186/s12859-016-1437-3.
1.1.
2017
R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical pharmacology and therapeutics, 101 (5), 684−695.10.1002/cpt.540.
1.1.
2017
Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186.10.1038/ng.3912.
1.1.
2017
Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. Plos Genetics, 13 (6), e1006812.10.1371/journal.pgen.1006812.
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Kukushkina, Viktorija; Modhukur, Vijayachitra; Suhorutšenko, Marina; Peters, Maire; Mägi, Reedik; Rahmioglu, Nilufer; Velthut-Meikas, Agne; Altmäe, Signe; Esteban, Francisco J; Vilo, Jaak; Zondervan, Krina; Salumets, Andres; Laisk-Podar, Triin (2017). DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase. Scientific Reports, 7 (1), 3916−3916.10.1038/s41598-017-03682-0.
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Eichstaedt, Christina A; Pagani, Luca; Antao, Tiago; Inchley, Charlotte E; Cardona, Alexia; Mörseburg, Alexander; Clemente, Florian J; Sluckin, Timothy J; Metspalu, Ene; Mitt, Mario; Mägi, Reedik; Hudjashov, Georgi; Metspalu, Mait; Mormina, Maru; Jacobs, Guy S; Kivisild, Toomas (2017). Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations. Scientific Reports, 7 (1), 13042−13042.10.1038/s41598-017-13382-4.
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Kraja, Aldi T.; Cook, James P.; Warren, Helen R.; Surendran, Praveen; Liu, Chunyu; Evangelou, Evangelos; Manning, Alisa K.; Grarup, Niels; Drenos, Fotios; Sim, Xueling; Smith, Albert Vernon; Amin, Najaf; Blakemore, Alexandra I. F.; Bork-Jensen, Jette; Brandslund, Ivan; Farmaki, Aliki-Eleni; Fava, Cristiano; Ferreira, Teresa; Herzig, Karl-Heinz; Giri, Ayush ... Howson, Joanna M. M. (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals. Circulation-cardiovascular Genetics, 10 (5), UNSP e001778.10.1161/CIRCGENETICS.117.001778.
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Mägi, R; Horikoshi, M; Sofer, T; Mahajan, A; Kitajima, H; Franceschini, N; McCarthy, MI; COGENT-Kidney, Consortium; T2D-GENES, Consortium; Morris, AP (2017). Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Human Molecular Genetics, 26 (18), 3639−3650.10.1093/hmg/ddx280.
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Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N. William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez ... McCarthy, Mark I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, ARTN 170179.10.1038/sdata.2017.179.
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Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish; Emdin, Connor; Alam, Dewan; Alves, Alexessander Couto; Amouyel, Philippe; Di Angelantonio, Emanuele; Arveiler, Dominique; Assimes, Themistocles L.; Auer, Paul L.; Baber, Usman; Ballantyne, Christie M.; Bang, Lia E.; Benn, Marianne; Bis, Joshua C. ... Kathiresan, Sekar (2017). Exome-wide association study of plasma lipids in > 300,000 individuals. Nature Genetics, 49 (12), 1758−1772.10.1038/ng.3977.
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Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994.10.1038/ejhg.2017.90.
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Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845.10.1038/ng.3841.
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Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D. ... Kilpelainen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults. Plos Genetics, 13 (4), ARTN e1006528.10.1371/journal.pgen.1006528.
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Rahmioglu, Nilufer; Lockstone, Helen; Ferreira, Teresa; Magi, Reedik; Van De Bunt, Martijn; Lindgren, Cecilia; Morris, Andrew; Becker, Christian; Zondervan, Krina (2017). Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis. Reproductive Sciences, 24, 205A−206A.
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Kaakinen, Marika; Magi, Reedik; Lagou, Vasiliki; Claringbould, Annique; Gaulton, Kyle; Fischer, Krista; Morris, Andrew; Prokopenko, Inga (2017). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. Genetic Epidemiology, 41 (7), 652−653.
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Suhorutshenko, M.; Kukushkina, V.; Velthut-Meikas, A.; Altmae, S.; Maire, P.; Magi, R.; Codoner, F.; Vilella, F.; Simon, C.; Salumets, A.; Laisk-Podar, T. (2017). Transcriptomic profile of early and mid-secretory endometrium revealed by RNA-seq: a paired sample cohort study. FEBS Journal, 284, 134−134.
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Pervjakova, Natalia; Kasela, Silva; Morris, Andrew P; Kals, Mart; Metspalu, Andres; Lindgren, Cecilia M; Salumets, Andres; Mägi, Reedik (2016). Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues. Epigenomics, 8 (6), 789−799.10.2217/epi.16.8.
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Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno. (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (10), 1296−1296.10.1038/ng1016-1296c.
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Fall, T; Xie, W; Poon, W; Yaghootkar, H; Mägi, R; GENESIS, Consortium; Knowles, JW; Lyssenko, V; Weedon, M; Frayling, TM; Ingelsson, E. (2015). Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes. Diabetes, 64 (7), 2676−2684.10.2337/db14-1710.
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Locke, AE.; Kahali, B.; Berndt, SI.; Justice, AE.; Pers, TH.; Day, FR.; Powell, C.; Vedantam, S.; Buchkovich, ML.; Yang, J.; Croteau-Chonka, DC.; Esko, T.; Fall, T.; Ferreira, T.; Gustafsson, S.; Kutalik, Z.; Luan, J.; Mägi, R.; Randall, JC.; Winkler, TW. ... Speliotes, EK. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197−206.10.1038/nature14177.
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The, Coffee, and, Caffeine, Genetics, Consortium; Cornelis, MC; Byrne, EM; Esko, T; Nalls, MA; Ganna, A; Paynter, N; Monda, KL; Amin, N; Fischer, K; Renstrom, F; Ngwa, JS; Huikari, V; Cavadino, A; Nolte, IM; Teumer, A; Yu, K; Marques-Vidal, P; Rawal, R; Manichaikul, A ... Chasman, DI. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647−656.10.1038/mp.2014.107.
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Lunetta, KL; Day, FR; Sulem, P; Ruth, KS; Tung, JY; Hinds, DA; Esko, T; Elks, CE; Altmaier, E; He, C; Huffman, JE; Mihailov, E; Porcu, E; Robino, A; Rose, LM; Schick, UM; Stolk, L; Teumer, A; Thompson, DJ; Traglia, M ... Perry, JR. (2015). Rare coding variants and X-linked loci associated with age at menarche. Nature Communications, 6 (7756), 1−7.10.1038/ncomms8756.
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Haller, Toomas; Kals, Mart; Esko, Tõnu; Mägi, Reedik; Fischer, Krista (2015). RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations. Briefings in bioinformatics, 16 (1), 39−44.10.1093/bib/bbt066.
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Männik, Katrin; Mägi, Reedik; Macé, Aurélien; Cole, Ben; Guyatt, Anna L; Shihab, Hashem A; Maillard, Anne M; Alavere, Helene; Kolk, Anneli; Reigo, Anu; Mihailov, Evelin; Leitsalu, Liis; Ferreira, Anne-Maud; Nõukas, Margit; Teumer, Alexander; Salvi, Erika; Cusi, Daniele; McGue, Matt; Iacono, William G; Gaunt, Tom R ... Reymond, Alexandre (2015). Copy Number Variations and Cognitive Phenotypes in Unselected Populations. JAMA : the journal of the American Medical Association, 313 (20), 2044−2054.10.1001/jama.2015.4845.
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Kaakinen, M.; Maegi, R.; Fischer, K.; Jarvelin, M. -R.; Morris, A. P.; Prokopenko, I. (2015). A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants. Human Heredity, 79: 43rd European Mathematical Genetics Meeting (EMGM), Brest, FRANCE, APR 16-17, 2015. Karger, 39−39. (1).
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Walsh, KM; Codd, V; Smirnov, IV; Rice, T; Decker, PA; Hansen, HM; Kollmeyer, T; Kosel, ML; Molinaro, AM; McCoy, LS; Bracci, PM; Cabriga, BS; Pekmezci, M; Zheng, S; Wiemels, JL; Pico, AR; Tihan, T; Berger, MS; Chang, SM; Prados, MD ... Wrensch, MR. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46 (7), 731−735.10.1038/ng.3004.
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Lokk, Kaie; Modhukur, Vijayachitra; Rajashekar, Balaji; Märtens, Kaspar; Mägi, Reedik; Kolde, Raivo; Koltšina, Marina; Nilsson, Torbjörn K.; Vilo, Jaak; Salumets, Andres; Tõnisson, Neeme (2014). DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biology, 15 (4), R54.10.1186/gb-2014-15-4-r54.
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Fischer, K.; Kettunen, J.; Würtz, P.; Haller, T.; Aki S. Havulinna, A.S.; Kangas, A.J.; Soininen, P.; Esko, T.; Tammesoo, M-L.; Mägi, R.; Smit, S.; Palotie, A.; SRipatti, S.; Veikko Salmaa, V.; Ala-Korpela, M.; Perola, M.; Metspalu, A. (2014). Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons. PLOS Medicine, 11 (2), e1001606.10.1371/journal.pmed.1001606.
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Raghavan, M.; Skoglund, P.; Graf, K.E.; Metspalu, M.; Albrechtsen, A.; Moltke, I.; Rasmussen, S.; Stafford, T.W. Jr.; Orlando, L.; Metspalu, E.; Karmin, M.; Tambets, K.; Rootsi, S.; Mägi, R.; Campos, P.F., Balanovska, E., Balanovsky, O., Khusnutdinova, E., Litvinov, S.; Osipova, L.P.; Fedorova, S.A.; Voevoda, M.I.; DeGiorgio, M.; Sicheritz-Ponten, T. ... Willerslev, E. (2014). Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature, 505 (7481), 87−91.10.1038/nature12736.
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Morris, A. P.; Teslovich, T. M.; Ferreira, T.; Mahajan, A.; Lee, Y.; Rayner, N. W.); Magi, R. (2014). Fine-mapping type 2 diabetes susceptibility loci with high-density imputation. DIABETOLOGIA, 57: 50th EASD Annual Meeting, Vienna, Austria, 15-19.09.2014. Springer, S50−S51.
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2013
Mägi, R.; Manning, S.; Yousseif, A.; Pucci, A.; Santini, F.; Karra, E.; Querci, G.; Pelosini, C.; McCarthy, M.I.; Lindgren, C.M.; Batterham, R.L. (2013). Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery. PLoS ONE, 8 (8), e70735.10.1371/journal.pone.0070735.
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Evans, DM; Brion, MJ; Paternoster, L; Kemp, JP; McMahon, G; Munafò, M; Whitfield, JB; Medland, SE; Montgomery, GW; GIANT, Consortium; CRP, Consortium; TAG, Consortium; Timpson, NJ; St Pourcain, B; Lawlor, DA; Martin, NG; Dehghan, A; Hirschhorn, J; Davey, Smith, G. (2013). Mining the human phenome using allelic scores that index biological intermediates. Plos Genetics, 9 (10), e1003919−e1003919.10.1371/journal.pgen.1003919.
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Vimaleswaran, KS.; Berry, DJ.; Lu, C.; Tikkanen, E.; Pilz, S.; Hiraki, LT.; Cooper, JD.; Dastani, Z.; Li, R.; Houston, DK.; Wood, AR.; Michaëlsson, K.; Vandenput, L.; Zgaga, L.; Yerges-Armstrong, LM.; McCarthy, MI.; Dupuis, J.; Kaakinen, M.; Kleber, ME.; Jameson, K. ... Hyppönen, E. (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLOS Medicine, 10 (2), e1001383.10.1371/journal.pmed.1001383.
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Paul, Dirk S.; Albers, Cornelis A.; Rendon, Augusto; Voss, Katrin; Stephens, Jonathan; HaemGen, Consortium; van der Harst, Pim; Chambers, John C.; Soranzo, Nicole; Ouwehand, Willem H.; Deloukas, Panos (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Research, 23 (7), 1130−1141.10.1101/gr.155127.113.
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Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpeläinen, TO; Esko, T; Mägi, R; Li, S; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A ... Heid, IM (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. Plos Genetics, 9 (6), e1003500.10.1371/journal.pgen.1003500.
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Thorgeirsson, TE; Gudbjartsson, DF; Sulem, P; Besenbacher, S; Styrkarsdottir, U; Thorleifsson, G; Walters, GB; TAG, Consortium; Oxford-GSK, Consortium; ENGAGE, consortium; Furberg, H; Sullivan, PF; Marchini, J; McCarthy, MI; Steinthorsdottir, V; Thorsteinsdottir, U; Stefansson, K. (2013). A common biological basis of obesity and nicotine addiction. Translational Psychiatry, 3, 1−7.10.1038/tp.2013.81.
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Fall, T.; Hagg, S.; Magi, R.; Ploner, A.; Fischer, K.; Horikoshi, M.; Sarin, AP.; Thorleifsson, G.; Ladenvall, C.; Kals, M.; Kuningas, M.; Draisma, HHM.; Ried, JS.; van Zuydam, NR.; Huikari, V.; Mangino, M.; Sonestedt, E.; Benyamin, B.; Nelson, CP.; Rivera, NV. ... Prokopenko, I. (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLOS Medicine, 10 (6), e1001474−e1001474.10.1371/journal.pmed.1001474.
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Migliano, A.; Romero, I.; Metspalu, M.; Leavesley, M.; Pagani, L.; Antao, T.; Huang, D.; Sherman, B.; Siddle, K.; Scoles, C.; Hudjashov, G.; Kaitokai, E.; Mandui, H.; Babalu, A.; Belatti, M.; Cagan, A.; Hopkinshow, B.; Show, C.; Tabbada, K.; Nelis, M. ... Kivisild, T. (2013). Evolution of the pygmy phenotype: evidence of positive selection from genome-wide scans in African, Asian and Melanesian pygmies. Human Biology, 85, 251−284.
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Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69.10.1038/ng.2606.
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Hu, YJ; Berndt, SI; Gustafsson, S; Ganna, A; Genetic Investigation of ANthropometric Traits (GIANT), Consortium; Hirschhorn, J; North, KE; Ingelsson, E; Lin, DY (2013). Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. American Journal of Human Genetics, 93 (2), 236−248.10.1016/j.ajhg.2013.06.011.
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Lagou, V.; Mägi, R.; Surakka, I. ; Sarin, A. -P.; Horikoshi, M.; Thorleifsson, G. ; Hagg, S.; Beekman, M.; Ladenvall, C.; Hottenga, J. -J.; Ried, J. S.; McCarthy, M. I.Morris, A.; Ripatti, S.; Prokopenko, I. (2013). Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S60.
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Tõnisson, N.; Lokk, K; Modhukur, V.; Rajashekar, B; Martens, K; Koltšina, M; Mägi, R.; Kolde, R.; Salumets, A. (2013). DNA metylome comparison of various human tissues. European Journal of Human Genetics: European Human Genetics Conference; Pariis, Prantsusmaa; 8.–11. juuni, 2013. Nature Publishing Group, 373−373. (21; Suppl 2).
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1.1.
2011
Metspalu, M.; Romero, IG.; Yunusbayev, B.; Chaubey, G.; Mallick, CB.; Hudjashov, G.; Nelis, M.; Mägi, R.; Metspalu, E.; Remm, M.; Pitchappan, R.; Singh, L.; Thangaraj, K.; Villems, R.; Kivisild, T. (2011). Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia. American Journal of Human Genetics, 89 (6), 731−44.10.1016/j.ajhg.2011.11.010.
1.1.
2011
Strawbridge, RJ; Dupuis, J; Prokopenko, I; Barker, A; Ahlqvist, E; Rybin, D; Petrie, JR; Travers, ME; Bouatia-Naji, N; Dimas, AS; Nica, A; Wheeler, E; Chen, H; Voight, BF; Taneera, J; Kanoni, S; Peden, JF; Turrini, F; Gustafsson, S; Zabena, C ... Florez, JC. (2011). Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes, 60 (10), 2624−2634.10.2337/db11-0415.
1.1.
2011
Zhu, H.; Shyh-Chang, N.; Segrè, AV.; Shinoda, G.; Shah, SP.; Einhorn, WS.; Takeuchi, A.; Engreitz, JM.; Hagan, JP.; Kharas, MG.; Urbach, A.; Thornton, JE.; Triboulet, R.; Gregory, RI.; DIAGRAM, Consortium; MAGIC, Investigators; Altshuler, D.; Daley, GQ. (2011). The Lin28/let-7 axis regulates glucose metabolism. Cell, 147 (1), 81−94.
1.1.
2011
Chaubey, Gyaneshwer; Metspalu, Mait; Choi, Ying; Mägi, Reedik; Gallego Romero, Irene; Soares, Pedro; van Oven, Mannis; Behar, Doron M; Rootsi, Siiri; Hudjashov, Georgi; Basu Mallick, Chandana; Karmin, Monika; Nelis, Mari; Parik, Jüri; Goverdhana Reddy, Alla; Metspalu, Ene; vanDriem, George; Xue, Yali; Tyler-Smith, Chris; Thangaraj, Kumarasamy ... Kivisild, Toomas. (2011). Population Genetic Structure in Indian Austroasiatic speakers: The Role of Landscape Barriers and Sex-specific Admixture. Molecular Biology and Evolution, 28(2), 1013−24.
1.1.
2011
Speliotes, EK; Yerges-Armstrong, LM; Wu, J; Hernaez, R; Kim, LJ; Palmer, CD; Gudnason, V; Eiriksdottir, G; Garcia, ME; Launer, LJ; Nalls, MA; Clark, JM; Mitchell, BD; Shuldiner, AR; NASH, CRN; GIANT, Consortium; MAGIC, Investigators; GOLD, Consortium (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. Plos Genetics, 7 (3), e1001324.10.1371/journal.pgen.1001324.
1.1.
2011
Kilpelaeinen, TO; den Hoed, M; Ong, KK; Grontved, A; Brage, S; Jameson, K; Cooper, C; Khaw, KT; Ekelund, U; Wareham, NJ; Loos, RJF; Early Growth Genetics Consortium, incl. Magi R (2011). Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 (4), 851−860.
1.1.
2011
The International Consortium for Blood Pressure Genome-Wide Association Studies, incl. Sõber, S.; Snieder, H.; Org, E.; Veldre, G.; Viigimaa, M.; Laan, M. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478 (7367), 103−109.10.1038/nature10405.
1.1.
2011
Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Johnson, A.D.; Bochud, M.; Rice, K.M.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C. ... Metspalu, A. et al (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics, 43, 1005−1011.10.1038/ng.922.
1.1.
2011
Yang, J.; Weedon, M.N.; Purcell, S.; Lettre, G.; Estrada, K.; Willer, C.J.; Smith, A.V.; Ingelsson, E.; O'Connell, J.R.; Mangino, M.; Mägi, R.; Madden, P.A.; Heath, A.C.; Nyholt, D.R.; Martin, N.G.; Montgomery, G.W.; Frayling, T.M.; Hirschhorn, J.N.; McCarthy, M.I.; Goddard, M.E. ... Visscher, P.M. (2011). Genomic inflation factors under polygenic inheritance. European Journal of Human Genetics, 19, 807−812.10.1038/ejhg.2011.39.
1.1.
2011
Sulem, P.; Gudbjartsson, D. F.; Geller, F.; Prokopenko, I.; Feenstra, B.; Aben, K.K.H.; Franke, B.; den Heijer, M.; Kovacs, P.; Stumvoll, M.; Mägi, R.; Yanek, L.R.; Becker, L.C.; Boyd, H.A.; Stacey, S.N.; Bragi Walters, G.; Jonasdottir, A.; Thorleifsson, G.; Holm, H.; Gudjonsson, S.A. ... Stefansson, K. (2011). Sequence variants at CYP1A1–CYP1A2 and AHR associate with coffee consumption. Human Molecular Genetics, 20 (10), 2071−2077.
1.1.
2011
Böger, CA; Chen, MH; Tin, A; Olden, M; Köttgen, A; de Boer, IH; Fuchsberger, C; O’Seaghdha, CM; Pattaro, C; Teumer, A; et, al. (2011). CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology, 22, 555−570.
1.1.
2011
Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
1.2.
2011
Mägi, R.; Kumar, A.; Morris, AP. (2011). Assessing the impact of missing genotype data in rare variant association analysis. BMC Proceedings, 9 (5), S107−S107.
1.1.
2010
Nettleton, JA; McKeown, NM; Kanoni, S; Lemaitre, RN; Hivert, MF; Ngwa, J; van Rooij, FJA; Sonestedt, E; Wojczynski, MK; Ye, Z; Tanaka, T; CHARGE, Whole Grain Foods Study Grp incl. Mägi, R. (2010). Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies. Diabetes Care, 33 (12), 2684−2691.
1.1.
2010
Speliotes, E.K.; Willer, C.J.; Berndt, S.I.; Monda, K.L.; Thorleifsson, G.; Jackson, A.U.; Allen, H.L.; Lindgren, C.M.; Luan, J.; Mägi, R.; Randall, J.C.; Vedantam, S.; Winkler, T.W.; Workalemahu, T.; Heid, I.M.; Qi, L.; Steinthorsdottir, V.; Weedon, M.N.; Wheeler, E.; Wood, A.R. ... Hayward, C. (2010). Genome-wide association study of 249,796 individuals reveals eighteen loci associated with body mass index. Nature Genetics, 11, 937−948.10.1038/ng.686.
1.1.
2010
Soranzo, Nicole; Sanna, Serena; Wheeler, Eleanor; Gieger, Christian; Radke, Dörte; Dupuis, Josée; Bouatia-Naji, Nabila; Langenberg, Claudia; Prokopenko, Inga; Stolerman, Elliot; Sandhu, Manjinder S; Heeney, Matthew M; Devaney, Joseph M; Reilly, Muredach P; Ricketts, Sally L; Stewart, Alexandre FR; Voight, Benjamin F; Willenborg, Christina; Wright, Benjamin; Altshuler, David ... Meigs, James B (2010). Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes, 59 (12), 3229−3239.10.2337/db10-0502.
1.1.
2010
Mägi, Reedik; Lindgren, Cecilia M.; Morris, Andrew P. (2010). Meta-analysis of sex-specific genome-wide association studies. Genetic Epidemiology, 34 (8), 846−853.10.1002/gepi.20540.
1.1.
2010
Lango Allen, Hana; Estrada, Karol; Lettre, Guillaume; Berndt, Sonja I; Weedon, Michael N; Rivadeneira, Fernando; Willer, Cristen J; Jackson, Anne U; Vedantam, Sailaja; Raychaudhuri, Soumya; Ferreira, Teresa; Wood, Andrew R; Weyant, Robert J; Segre, Ayellet V; Speliotes, Elizabeth K; Wheeler, Eleanor; Soranzo, Nicole; Park, Ju-Hyun; Yang, Jian; Gudbjartsson, Daniel ... Hirschhorn, Joel N (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467 (7317), 832−838.
1.1.
2010
Oitmaa, E.; Peters, M.; Vaidla, K.; Andreson, R.; Mägi, R.; Slavin, G.; Velthut, .; Tõnisson, N.; Reimand, T.; Remm, M.; Schneider, M.; Õunap, K.; Salumets, A.; Metspalu, A. (2010). Molecular diagnosis of Down Syndrome using Quantitative APEX-2 microarrays. Prenatal Diagnosis, 30, 1170−1177.
1.1.
2010
Dupuis, J.; Langenberg, C.; Prokopenko, I.; Saxena, R.; Soranzo, N.; Jackson, A.U.; Wheeler, E.; Glazer, N.L.; Bouatia-Naji, N.; Gloyn, A.L.; Lindgren, C.M.; Mägi, R.; Morris, A.P.; Randall, J.; Johnson, T.; Elliott, P.; Rybin, D.; Thorleifsson, G.; Steinthorsdottir, V.; Henneman, P. ... Mitchell, B.D (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42 (2), 105−116.10.1038/ng.520.
1.1.
2010
Mägi, R; Morris, AP. (2010). GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics, 11 (288), 288.10.1186/1471-2105-11-288.
1.1.
2010
Ingelsson, E.; Langenberg, C.; Hivert, M.F.; Prokopenko, I.; Lyssenko, V.; Dupuis, J.; Mägi, R.; Sharp, S.; Jackson, A.U.; Assimes, T.L.; Shrader, P.; Knowles, J.W.; Zethelius, B.; Abbasi, F.A.; Bergman, R.N.; Bergmann, A.; Berne, C.; Boehnke, M.; Bonnycastle, L.L.; Bornstein, S.R. ... Florez, JC. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. DIABETES, 59: 59th Annual Meeting of the American-Society-of-Human-Genetics; Honolulu, HI, USA; OCT 20-24, 2009. 1266−1275. (5).10.2337/db09-1568.
1.1.
2010
Freathy, R.M.; Mook-Kanamori, D.O.; Sovio, U.; Prokopenko, I.; Timpson, N.J.; Berry, D.J.; Warrington, N.M.; Widen, E.; Hottenga, J.J.; Kaakinen, M.; Lange, L.A.; Bradfield, J.P.; Kerkhof, M.; Marsh, J.A.; Mägi, R.; et, al. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 (5), 430−435.
1.1.
2010
Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; et, al.; Mägi, R.; et, al. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42 (5), 376−384.10.1038/ng.568.
1.1.
2010
Thorgeirsson, TE.; Gudbjartsson, DF.; Surakka, I.; Vink, JM.; Amin, N.; Geller, F.; Sulem, P.; Rafnar, T.; Esko, T.; Walter, S.; Gieger, C.; Rawal, R.; Mangino, M.; Prokopenko, I.; Mägi, R.; Keskitalo, K.; Gudjonsdottir, IH.; Gretarsdottir, S.; Stefansson, H.; Thompson, JR. ... Stefansson, K (2010). Sequence variants at CHRNB3-CHRNA6 and affect smoking behavior. Nature Genetics, 42 (5), 448−453.
5.1.
2010
Mägi, R.; Hottenga, J. J.; Prokopenko, I. (2010). A genome-wide association analysis of over 75,000 individuals identifies gender-specific effects for fasting glycaemic traits. Diabetologia, 53: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, SWEDEN, SEP 20-24, 2010. Springer, S28−S28.
5.1.
2010
Mägi, R; Morris, AP. (2010). GRANVIL: Rare Variant Analysis of Genome-Wide Association Studies. Genetic Epidemiology, 34: 19th Annual Meeting of the International-Genetic-Epidemiology-Society, Boston, MA, OCT 10-12, 2010. Wiley-Blackwell, 926−926. (8).
1.1.
2009
Nelis, M.; Esko, T.; Mägi, R.; Zimprich, F.; Zimprich, A.; Toncheva, D.; Karachanak, S.; Piskácková, T.; Balascák, I.; Peltonen, L.; Jakkula, E.; Rehnström, K.; Lathrop, M.; Heath, S.; Galan, P.; Schreiber, S.; Meitinger, T.; Pfeufer, A.; Wichmann, HE.; Melegh, B. ... Metspalu, A. (2009). Genetic structure of Europeans: a view from the North-East. PLoS ONE, 4(5), e5472.
5.1.
2009
Prokopenko, I; Dupuis, J; Langenberg, C; Saxena, R; Soranzo, N; Jackson, AU; Wheeler, E; Glazer, NL; Mägi, R; Bouatia-Naji, N; Florez, JC; Barroso, I. (2009). Novel genetic loci implicated in fasting glucose homeostasis and their impact on related metabolic traits. Diabetologia, 52: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, AUSTRIA, SEP 30-OCT 02, 2009.. Springer, S38−S38.
1.1.
2008
Krjutskov, K.; Andreson, R.; Mägi, R.; Nikopensius, T.; Khrunin, A.; Mihailov, E.; Tammekivi, V.; Sork, H.; Remm, M.; Metspalu, A. (2008). Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays. Nucleic Acids Research, 36 (12), e75.
1.1.
2008
Tamm, R.; Oselin, K.; Kallassalu, K.; Magi, R.; Anier, K.; Remm, M.; Metspalu, A. (2008). Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population. Clinical Chemistry and Laboratory Medicine, 46 (7), 974−979.
5.2.
2008
Oitmaa, Eneli; Krjutskov, Kaarel; Mägi, Reedik ; Andreson, Reidar ; Raukas, Elve; Remm, Maido; Tõnisson, Neeme; Schneider, Marion; Metspalu, Andres (2008). Molecular diagnostics of Down syndrome using quantitative APEX microarrays. RBM online, vol.16-suppl. 3: Eighth International Symposium of Preimplantation Genetic Diagnosis, Barcelona, April 23-26, 2008. S17.
1.1.
2007
Magi, R.; Pfeufer, A.; Nelis, M.; Montpetit, A.; Metspalu, A.; Remm, M. (2007). Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. BMC Genomics, 8 (159), x.
1.1.
2007
Kuningas, M.; Mägi, R.; Westendorp, R.G.; Slagboom, P.E.; Remm, M.; van Heemst, D. (2007). Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. European Journal of Human Genetics, 15 (3), 294−301.10.1038/sj.ejhg.5201766.
1.1.
2006
Kaminski, S.; Brym, P.; Rusc, A.; Wojcik, E.; Ahman, A.; Mägi, R. (2006). Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (APEX) microarray. Animal biotechnology, 17 (1), 1−11.
1.1.
2006
Montpetit, A.; Nelis, M.; Laflamme, P.; Magi, R.; Ke, X.Y.; Remm, M.; Cardon, L.; Hudson, T.J.; Metspalu, A. (2006). An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. Plos Genetics, 2 (3), 282−290.
3.2.
2006
Mägi, R.; Kaplinski, L.; Remm, M. (2006). The Whole Genome TagSNP Selection and Transferability Among HapMap Populations. Pacific Symposium on Biocomputing 2006: 2006. World Scientific Publ Co Pte Ltd, 535−543.
1.1.
2005
Mueller, J. C.; Lõhmussaar, E.; Mägi, R.; Remm, M.; Bettecken, T.; Lichtner, P.; Huber, S.; Illig, T; Luedemann, J.; Schreiber, S.; Wichmann, H. E.; Pramstaller, P.; Romeo, G.; Testa, A.; Metspalu, A.; Meitinger, T. (2005). Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations. American Journal of Human Genetics, 76 (3), 387−398.
1.1.
2002
Liira, J.; Zobel, K.; Magi, R.; Molenberghs, G. (2002). Vertical structure of herbaceous canopies: the importance of plant growth-form and species-specific traits. Plant Ecology, 163 (1), 123−134.
1.1.
2002
Dawson, E.; Abecasis, GR.; Bumpstead, S.; Chen, Y.; Hunt, S.; Beare, DM.; Pabial, J.; Dibling, T.; Tinsley, E.; Kirby, S.; Carter, D.; Papaspyridonos, M.; Livingstone, S.; Ganske, R.; Lohmmussaar, E.; Zernant, J.; Tonisson, N.; Remm, M.; Magi, R.; Puurand, T. ... Dunham, I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature, 418 (6897), 544−548.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using APEX arrays. European Journal of Human Genetics, 10, 299−299.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Puurano, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using Arrayed Primer EXtension (APEX) technology. American Journal of Human Genetics, 71 (4), 449−449.
5.1.
2001
Metspalu, A.; Zernant, J.; Lohmussaar, E.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, L.; Pavel, H.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M. (2001). SNP analysis of the human chromosome 22 using APEX arrays. American Journal of Human Genetics, 69 (4), 408−408.

Tööstusomand

3.06.2019

Reedik Mägi

https://www.etis.ee/CV/Reedik_Mägi/eng
18.08.1978
737 4045
reedik.magi@ut.ee

Career

Institution and occupation
01.01.2018–...   
University of Tartu, Institute of Genomics, Senior Research Fellow in Bioinformatics (1,00)
01.09.2016–31.12.2017   
University of Tartu, Estonian Genome Center , Senior Research Fellow in Bioinformatics (1,00)
01.09.2011–31.08.2016   
University of Tartu, Estonian Genome Center , Senior Research Fellow (1,00)
01.02.2010–31.08.2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow (0,10)
2009–2011   
University Of Oxford, Marie Curie Research Fellow in Wellcome Trust Centre for Human Genetics (1,00)
01.09.2008–31.08.2011   
Estonian Biocentre, Extraordinary Researcher (0,10)
01.04.2008–31.01.2010   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow extraordinarius (0,10)
2008–2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Chair of Bioinformatics, Extraordinary Researcher (0,10)
2008–2009   
University Of Oxford, Senior Statistical Geneticist (1,00)
01.01.2008–31.12.2011   
Wellcome Trust Centre for Human Genetics, University of Oxford; postdoc
01.01.2008–31.03.2008   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow extraordinarius (1,00)
01.12.2007–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.08.2007–30.11.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,10)
01.02.2007–31.07.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.09.2006–31.01.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.07.2006–31.08.2006   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.09.2005–30.06.2006   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.07.2005–31.08.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.02.2005–30.06.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.02.2004–31.01.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
2004–2008   
University of Tartu, University of Tartu, scientist (0,50)
01.01.2002–2004   
Biodata Ltd, Biodata Ltd., IT specialist (0,50)
01.01.2000–31.12.2002   
Asper Biotech Ltd., IT specialist
 
 
Education
2003–2007   
University of Tartu, PhD stud. of bioinformatics
2000–2003   
University of Tartu, MSc of plant ecology
1996–2000   
University of Tartu, BS of botany and ecology
 
 
R&D related managerial and administrative work
2016−...   
Co-leader of annual "Introduction to the statistical analysis of genome-wide association studies" course in Imperial College of London, UK
2017−2017   
Organizer and the member of scientific committee of of "European Mathematical Genetics Meeting"

Qualifications

Academic degrees
Reedik Mägi, Doctor's Degree, 2007, (sup) Maido Remm, The Linkage Disequilibrium And The Selection of Genetic markers For Association Studies in European Populations, University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology.
Reedik Mägi, Research Master's Degree, 2003, (sup) Kristjan Zobel, Rohu- ja puhmarinde võra struktuur 27 Eesti niidu- ja metsakoosluses, University of Tartu, Faculty of Biology and Geography, Institute of Botany and Ecology.
 
 
Honours & awards
2019, Reedik Mägi, National Science Award in chemistry and molecular biology for the series of works "Basic research on genetics and genomics for the implementation of personal medicine in Estonia" (Esko, Mägi, Fischer, Milani)
2009, Reedik Mägi, EC FP7 Marie Curie IEF (2009-2011)
2008, Reedik Mägi, Post-doctoral fellowship from Estonian Biocentre (ECOGENE)
 
 
Field of research
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine; CERCS SPECIALTY: B100 History and philosophy of biomedical sciences, theoretical biology, general aspects of evolution ; SPECIALITY: Main scientific interests include population and statistical genetics, as well as software development for implementing statistical methods for genetic studies. I have worked on the development and implementation of methodology of meta-analysis, rare-variant analysis, and sequencing data analysis. I am also participating in several association studies, which are mainly related to T2D and various anthropometric phenotypes.
 
 

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F; Feufer, Arne P; Marullo, Letizia; Mägi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in medicine.10.2217/bmm-2017-0431 [forthcoming].
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in medicine, 1−8.10.1038/s41436-018-0311-2 [forthcoming].
1.1.
2019
Reisberg, Sulev; Galwey, Nicholas; Avillach, Paul; Sahlqvist, Anna-Stina; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Vilo, Jaak; James, Glen (2019). Comparison of variation in frequency for SNPs associated with asthma or liver disease between Estonia, HapMap populations and the 1000 genome project populations. International Journal of Immunogenetics, 46 (1), 1−10.10.1111/iji.12413.
1.1.
2019
Tasa, T.; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 27 (3), 442−454.10.1038/s41431-018-0300-6.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, in press.10.1111/eva.12780 [forthcoming].
1.1.
2019
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Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648.10.1038/s41588-019-0378-y.
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2019
Wiberg, Akira; Ng, Michael; Schmid, Annina B.; Smillie, Robert W.; Baskozos, Georgios; Holmes, Michael V.; Kunnapuu, K.; Magi, R.; Bennett, David L.; Furniss, Dominic (2019). A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nature Communications, 10, ARTN 1030.10.1038/s41467-019-08993-6.
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2019
James, Glen; Reisberg, Sulev; Lepik, Kaido; Galwey, Nicholas; Avillach, Paul; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Alexander, Myriam; Waterworth, Dawn; Loomis, A. Katrina; Vilo, Jaak (2019). An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank. PLoS ONE, 14 (4), e0215026.10.1371/journal.pone.0215026.
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2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
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2018
Pervjakova, N.; Kukushkina, V.; Haller, T.; Kasela, S.; Joensuu, A.; Kristiansson, K.; Annilo, T.; Perola, M.; Salomaa, V.; Jousilahti, P.; Metspalu, A.; Magi, R. (2018). Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene. Biomarkers in medicine, 12 (5), 439−446.10.2217/bmm-2018-0020.
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Suhorutshenko, Marina; Kukushkina, Viktorija; Velthut-Meikas, Agne; Altmäe, Signe; Peters, Maire; Mägi, Reedik; Krjutškov, Kaarel; Koel, Mariann; Codoñer, Francisco; Martinez-Blanch, Juan; Vilella, Felipe; Simón, Carlos; Salumets, Andres; Laisk, Triin (2018). Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. Human Reproduction, 33 (11), 2074−2086.10.1093/humrep/dey301.
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Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
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Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
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Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. Jornal Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
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2018
Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516.10.1038/s41588-018-0241-6.
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2018
Pasman, Joëlle A; Verweij, Karin J H; Gerring, Zachary; Stringer, Sven; Sanchez-Roige, Sandra; Treur, Jorien L; Abdellaoui, Abdel; Nivard, Michel G; Baselmans, Bart M L; Ong, Jue-Sheng; Ip, Hill F; van der Zee, Matthijs D; Bartels, Meike; Day, Felix R; Fontanillas, Pierre; Elson, Sarah L; ,; de Wit, Harriet; Davis, Lea K; MacKillop, James ... Vink, Jacqueline M (2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21 (9), 1161−1170.10.1038/s41593-018-0206-1.
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Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429.10.1038/s41588-018-0205-x.
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Vals, M.A.; Pajusalu, S.; Kals, M.; Mägi, R.; Õunap, K. (2018). The Prevalence of PMM2-CDG in Estonia Based on Population Carrier Frequencies and Diagnosed Patients. JIMD Reports, 39, 13−17.10.1007/8904_2017_41.
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2017
Huan, Tianxiao; Joehanes, Roby; Schurmann, Claudia; Schramm, Katharina; Pilling, Luke C; Peters, Marjolein J; Mägi, Reedik; DeMeo, Dawn; O'Connor, George T; Ferrucci, Luigi; Teumer, Alexander; Homuth, Georg; Biffar, Reiner; Völker, Uwe; Herder, Christian; Waldenberger, Melanie; Peters, Annette; Zeilinger, Sonja; Metspalu, Andres; Hofman, Albert ... Levy, Daniel (2017). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics, 25 (21), 1−33.10.1093/hmg/ddw288.
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Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110.10.1186/s12859-017-1530-2.
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Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25.10.1186/s12859-016-1437-3.
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R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical pharmacology and therapeutics, 101 (5), 684−695.10.1002/cpt.540.
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Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186.10.1038/ng.3912.
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Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. Plos Genetics, 13 (6), e1006812.10.1371/journal.pgen.1006812.
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2017
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2017
Eichstaedt, Christina A; Pagani, Luca; Antao, Tiago; Inchley, Charlotte E; Cardona, Alexia; Mörseburg, Alexander; Clemente, Florian J; Sluckin, Timothy J; Metspalu, Ene; Mitt, Mario; Mägi, Reedik; Hudjashov, Georgi; Metspalu, Mait; Mormina, Maru; Jacobs, Guy S; Kivisild, Toomas (2017). Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations. Scientific Reports, 7 (1), 13042−13042.10.1038/s41598-017-13382-4.
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Kraja, Aldi T.; Cook, James P.; Warren, Helen R.; Surendran, Praveen; Liu, Chunyu; Evangelou, Evangelos; Manning, Alisa K.; Grarup, Niels; Drenos, Fotios; Sim, Xueling; Smith, Albert Vernon; Amin, Najaf; Blakemore, Alexandra I. F.; Bork-Jensen, Jette; Brandslund, Ivan; Farmaki, Aliki-Eleni; Fava, Cristiano; Ferreira, Teresa; Herzig, Karl-Heinz; Giri, Ayush ... Howson, Joanna M. M. (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals. Circulation-cardiovascular Genetics, 10 (5), UNSP e001778.10.1161/CIRCGENETICS.117.001778.
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2017
Mägi, R; Horikoshi, M; Sofer, T; Mahajan, A; Kitajima, H; Franceschini, N; McCarthy, MI; COGENT-Kidney, Consortium; T2D-GENES, Consortium; Morris, AP (2017). Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Human Molecular Genetics, 26 (18), 3639−3650.10.1093/hmg/ddx280.
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Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish; Emdin, Connor; Alam, Dewan; Alves, Alexessander Couto; Amouyel, Philippe; Di Angelantonio, Emanuele; Arveiler, Dominique; Assimes, Themistocles L.; Auer, Paul L.; Baber, Usman; Ballantyne, Christie M.; Bang, Lia E.; Benn, Marianne; Bis, Joshua C. ... Kathiresan, Sekar (2017). Exome-wide association study of plasma lipids in > 300,000 individuals. Nature Genetics, 49 (12), 1758−1772.10.1038/ng.3977.
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Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994.10.1038/ejhg.2017.90.
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Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845.10.1038/ng.3841.
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Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D. ... Kilpelainen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults. Plos Genetics, 13 (4), ARTN e1006528.10.1371/journal.pgen.1006528.
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Rahmioglu, Nilufer; Lockstone, Helen; Ferreira, Teresa; Magi, Reedik; Van De Bunt, Martijn; Lindgren, Cecilia; Morris, Andrew; Becker, Christian; Zondervan, Krina (2017). Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis. Reproductive Sciences, 24, 205A−206A.
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Kaakinen, Marika; Magi, Reedik; Lagou, Vasiliki; Claringbould, Annique; Gaulton, Kyle; Fischer, Krista; Morris, Andrew; Prokopenko, Inga (2017). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. Genetic Epidemiology, 41 (7), 652−653.
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Suhorutshenko, M.; Kukushkina, V.; Velthut-Meikas, A.; Altmae, S.; Maire, P.; Magi, R.; Codoner, F.; Vilella, F.; Simon, C.; Salumets, A.; Laisk-Podar, T. (2017). Transcriptomic profile of early and mid-secretory endometrium revealed by RNA-seq: a paired sample cohort study. FEBS Journal, 284, 134−134.
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Teumer, A.; Qi, Q.; Nethander, M.; Aschard, H.; Bandinelli, S.; Beekman, M.; Berndt, S. I.; Bidlingmaier, M.; Broer, L.; Cappola, A.; Ceda, G. P.; Chanock, S.; Chen, M. -H.; Chen, T. C.; Chen, Y. -D. I.; Chung, J.; Miglianico, Del Greco F.; Eriksson, J.; Ferrucci, L.; Friedrich, N. ... Kaplan, R. C. (2017). Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016). Aging Cell, 16 (4), 898−898.10.1111/acel.12612.
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Pervjakova, Natalia; Kasela, Silva; Morris, Andrew P; Kals, Mart; Metspalu, Andres; Lindgren, Cecilia M; Salumets, Andres; Mägi, Reedik (2016). Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues. Epigenomics, 8 (6), 789−799.10.2217/epi.16.8.
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Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement; Fontanillas, Pierre; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M ... McCarthy, Mark I (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41−47.10.1038/nature18642.
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Chami, Nathalie; Chen, Ming-Huei; Slater, Andrew J; Eicher, John D; Evangelou, Evangelos; Tajuddin, Salman M; Love-Gregory, Latisha; Kacprowski, Tim; Schick, Ursula M; Nomura, Akihiro; Giri, Ayush; Lessard, Samuel; Brody, Jennifer A; Schurmann, Claudia; Pankratz, Nathan; Yanek, Lisa R; Manichaikul, Ani; Pazoki, Raha; Mihailov, Evelin; Hill, W David ... Lettre, Guillaume (2016). Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. American Journal of Human Genetics, 99 (1), 8−21.10.1016/j.ajhg.2016.05.007.
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Tšuiko, O.; Nõukas, M.; Žilina, O.; Hensen, K.; Tapanainen, J.; Mägi, R.; Kals, M.; Kivistik, PA.; Haller-Kikkatalo, K.; Salumets, A.; Kurg, A. (2016). Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases. Human Reproduction, 31 (8), 1913−1925.10.1093/humrep/dew142.
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Läll, Kristi; Mägi, Reedik; Morris, Andrew; Metspalu, Andres; Fischer, Krista (2016). Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores. Genetics in medicine, 1−10.10.1038/gim.2016.103.
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Ganna A, Genovese G, Howrigan DP, Byrnes A, Kurki MI, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman CM, Neale BM. (2016). Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nature Neuroscience, 19 (12), 1563−1565.10.1038/nn.4404.
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Mägi, R.; Manning, S.; Yousseif, A.; Pucci, A.; Santini, F.; Karra, E.; Querci, G.; Pelosini, C.; McCarthy, M.I.; Lindgren, C.M.; Batterham, R.L. (2013). Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery. PLoS ONE, 8 (8), e70735.10.1371/journal.pone.0070735.
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Codd, V; Nelson, CP; Albrecht, E; Mangino, M; Deelen, J; Buxton, JL; Hottenga, JJ; Fischer, K; Esko, T; Surakka, I; Broer, L; Nyholt, DR; Leach, IM; Salo, P; Hägg, S; Matthews, MK; Palmen, J; Norata, GD; O'Reilly, PF; Saleheen, D ... Samani, NJ (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45 (4), 422−427.10.1038/ng.2528.
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2013
Hu, YJ; Berndt, SI; Gustafsson, S; Ganna, A; Genetic Investigation of ANthropometric Traits (GIANT), Consortium; Hirschhorn, J; North, KE; Ingelsson, E; Lin, DY (2013). Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. American Journal of Human Genetics, 93 (2), 236−248.10.1016/j.ajhg.2013.06.011.
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Parsa, A; Fuchsberger, C; Köttgen, A; O'Seaghdha, CM; Pattaro, C; de Andrade, M; Chasman, DI; Teumer, A; Endlich, K; Olden, M; Chen, MH; Tin, A; Kim, YJ; Taliun, D; Li, M; Feitosa, M; Gorski, M; Yang, Q; Hundertmark, C; Foster, MC ... Böger, CA. (2013). Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function. Journal of the American Society of Nephrology, 24 (12), 2105−2117.10.1681/ASN.2012100983.
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2013
Lagou, V.; Mägi, R.; Surakka, I. ; Sarin, A. -P.; Horikoshi, M.; Thorleifsson, G. ; Hagg, S.; Beekman, M.; Ladenvall, C.; Hottenga, J. -J.; Ried, J. S.; McCarthy, M. I.Morris, A.; Ripatti, S.; Prokopenko, I. (2013). Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S60.
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2013
Horikoshi, M.; Mägi, R.; Surakka, I.; Sarin, A. -P.; Mahajan, A.; Marullo, L.; Ferreira, T. ; Esko, T.; Lindgren, C. M.; Morris, A. P.; McCarthy, M. I.; Ripatti, S.; Prokopenko, I; ENGAGE, Consortium. (2013). Large-scale genome-wide association meta-analysis of the 1000 genomes project imputed data identifies novel susceptibility loci for glycaemic and obesity traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S61.
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2013
Horikoshi, Momoko; Magi, Reedik; Surakka, Ida; Sarin, Antti-Pekka; Mahajan, Anubha; Marullo, Letizia; Ferreira, Teresa; Esko, Tonu; Morris, Andrew P.; Mccarthy, Mark I.; Ripatti, Samuli; Prokopenko, Inga (2013). Large-Scale Genome-Wide Association Meta-Analysis using Imputation from the Dense 1000 Genomes Project Map Identifies Novel Susceptibility Loci for Glycemic and Obesity Traits. Diabetes, A83−A83.
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5.2.
2013
Tõnisson, N.; Lokk, K; Modhukur, V.; Rajashekar, B; Martens, K; Koltšina, M; Mägi, R.; Kolde, R.; Salumets, A. (2013). DNA metylome comparison of various human tissues. European Journal of Human Genetics: European Human Genetics Conference; Pariis, Prantsusmaa; 8.–11. juuni, 2013. Nature Publishing Group, 373−373. (21; Suppl 2).
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2012
Chasman, DI.; Fuchsberger, C.; Pattaro, C.; Teumer, A.; Boger, CA.; Endlich, K.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Kottgen, A. (2012). Integration of Genome-Wide Association Studies with Biological Knowledge Identifies Six Novel Genes Related to Kidney Function. Human Molecular Genetics, 21 (24), 5329−5343.10.1093/hmg/dds369.
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2012
Nürnberg, ST.; Rendon, A.; Smethurst, PA.; Paul, DS.; Voss, K.; Thon, JN.; Lloyd-Jones, H.; Sambrook, JG.; Tijssen, MR.; Gieger, C.; Radhakrishnan, A.; Cvejic, A.; Tang, W.; Porcu, E.; Pistis, G.; Serbanovic-Canic, J.; Elling, U.; Goodall, AH.; Labrune, Y.; Lopez, LM. ... Ouwehand, W. (2012). A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood, 120 (24), 4859−4868.10.1182/blood-2012-01-401893.
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Mägi, R; Asimit, JL; Day-Williams, AG; Zeggini, E; Morris, AP. (2012). Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases. Genetic Epidemiology, 36 (8), 785−796.10.1002/gepi.21675.
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Okada, Y; Sim, X; Go, MJ; Wu, JY; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, SC; Wong, TY; Liu, J; Young, TL; Aung, T; Seielstad, M; Teo, YY; Kim, YJ; Lee, JY; Han, BG ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904−909.10.1038/ng.2352.
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2012
Yang, J; Loos, RJ; Powell, JE; Medland, SE; Speliotes, EK; Chasman, DI; Rose, LM; Thorleifsson, G; Steinthorsdottir, V; Mägi, R; Waite, L; Vernon, Smith, A; Yerges-Armstrong, LM; Monda, KL; Hadley, D; Mahajan, A; Li, G; Kapur, K; Vitart, V; Huffman, JE ... Visscher, PM (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature, 490 (7419), 267−272.DOI:10.1038/nature11401.
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Scott, RA.; Lagou, V.; Welch, RP.; Wheeler, E.; Montasser, ME.; Luan, J.; Mägi, R.; Strawbridge, RJ.; Rehnberg, E.; Gustafsson, S.; Kanoni, S.; Rasmussen-Torvik, LJ.; Yengo, L.; Lecoeur, C.; Shungin, D.; Sanna, S.; Sidore, C.; Johnson, PC.; Jukema, JW.; Johnson, T. ... Barroso, I. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991−1005.10.1038/ng.2385.
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Fox, Caroline S; Liu, Yongmei; White, Charles C; Feitosa, Mary; Smith, Albert V; Heard-Costa, Nancy; Lohman, Kurt; Johnson, Andrew D; Foster, Meredith C; Greenawalt, Danielle M; Griffin, Paula; Ding, Jinghong; Newman, Anne B; Tylavsky, Fran; Miljkovic, Iva; Kritchevsky, Stephen B; Launer, Lenore; Garcia, Melissa; Eiriksdottir, Gudny; Carr, J Jeffrey ... GLGC, Consortium. (2012). Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. Plos Genetics, 8 (5), e1002695−e1002695.10.1371/journal.pgen.1002695.
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Verhoeven, Virginie J M; Hysi, Pirro G; Saw, Seang-Mei; Vitart, Veronique; Mirshahi, Alireza; Guggenheim, Jeremy A; Cotch, Mary Frances; Yamashiro, Kenji; Baird, Paul N; Mackey, David A; Wojciechowski, Robert; Ikram, M Kamran; Hewitt, Alex W; Duggal, Priya; Janmahasatian, Sarayut; Khor, Chiea-Chuen; Fan, Qiao; Zhou, Xin; Young, Terri L; Tai, E-Shyong ... Klaver, Caroline C W. (2012). Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Human Genetics, 131 (9), 1467−1480.10.1007/s00439-012-1176-0.
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Ellis, JW.; Chen, MH.; Foster, MC.; Liu, CT.; Larson, MG.; de Boer, I.; Kottgen, A.; Parsa, A.; Bochud, M.; Boger, CA.; Kao, L.; Fox, CS.; O'Seaghdha, CM; CKDGen, Consortium ; CARe Renal, Consortium. (2012). Validated SNPs for eGFR and their associations with albuminuria. Human Molecular Genetics, 21 (14), 3293−3298.10.1093/hmg/dds138.
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Parts, L.; Hedman, AK.; Keildson, S.; Knights, AJ.; Abreu-Goodger, C.; van de Bunt, M.; Guerra-Assuncao, JA.; Bartonicek, N.; van Dongen, S.; Mägi, R.; Nisbet, J.; Barrett, A.; Rantalainen, M.; Nica, AC.; Quail, MA.; Small, KS.; Glass, D.; Enright, AJ.; Winn, J.; Deloukas, P. ... Lindgren, CM. (2012). Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue. Plos Genetics, 8 (5), e1002704−e1002704.10.1371/journal.pgen.1002704.
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Taal, HR.; St Pourcain, B.; Thiering, E.; Das, S.; Mook-Kanamori, DO.; Warrington, NM.; Kaakinen, M.; Kreiner-Moller, E.; Bradfield, JP.; Freathy, RM.; Geller, F.; Guxens, M.; Cousminer, DL.; Kerkhof, M.; Timpson, NJ.; Ikram, MA.; Beilin, LJ.; Bonnelykke, K.; Buxton, JL.; Charoen, P. ... DeCarli, C. (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5), 532−538.10.1038/ng.2238.
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2012
Ikram, MA.; Fornage, M.; Smith, AV.; Seshadri, S.; Schmidt, R.; Debette, S.; Vrooman, HA.; Sigurdsson, S.; Ropele, S.; Taal, HR.; Mook-Kanamori, DO.; Coker, LH.; Longstreth, WT.; Niessen, WJ.; DeStefano, AL.; Beiser, A.; Zijdenbos, AP.; Struchalin, M.; Jack, CR.; Rivadeneira, F. ... Wilson, JF. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5), 539−544.10.1038/ng.2245.
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2012
Manning, AK.; Hivert, MF.; Scott, RA.; Grimsby, JL.; Bouatia-Naji, N.; Chen, H.; Rybin, D.; Liu, CT.; Bielak, LF.; Prokopenko, I.; Amin, N.; Barnes, D.; Cadby, G.; Hottenga, JJ.; Ingelsson, E.; Jackson, AU.; Johnson, T.; Kanoni, S.; Ladenvall, C.; Lagou, V. ... Langenberg, C. (2012). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44 (6), 659−669.10.1038/ng.2274.
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Bradfield, JP.; Taal, HR.; Timpson, NJ.; Scherag, A.; Lecoeur, C.; Warrington, NM.; Hypponen, E.; Holst, C.; Valcarcel, B.; Thiering, E.; Salem, RM.; Schumacher, FR.; Cousminer, DL.; Sleiman, PMA.; Zhao, JH.; Berkowitz, RI.; Vimaleswaran, KS.; Jarick, I.; Pennell, CE.; Evans, DM. ... Grant, SFA. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44 (5), 526−531.10.1038/ng.2247.
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2012
Pattaro, C.; Köttgen, A.; Teumer, A.; Garnaas, M.; Boger, CA.; Fuchsberger, C.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Fox, CS. (2012). Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function. Plos Genetics, 8 (3), e1002584−e1002584.10.1371/journal.pgen.1002584.
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2012
Yang, J; Ferreira, T; Morris, AP; Medland, SE; GIANT, consortium; DIAGRAM, consortium; Madden, PAF; Heath, AC; Martin, NG; Montgomery, GW; Weedon, MN; Loos, RJ; Frayling, TM; McCarthy, MI; Hirschhorn, JN; Goddard, ME; Visscher, PM. (2012). Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nature Genetics, 44, 369−375.
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2012
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2012
Min, Josine L.; Nicholson, George; Halgrimsdottir, Ingileif; Almstrup, Kristian; Petri, Andreas; Barrett, Amy; Travers, Mary; Rayner, Nigel W.; Mägi, Reedik; Pettersson, Fredrik H.; Broxholme, John; Neville, Matt J.; Wills, Quin F.; Cheeseman, Jane; The GIANT, Consortium; The MolPAGE, Consortium; Allen, Maxine; Holmes, Chris C.; Spector, Tim D.; Fleckner, Jan ... Zondervan, Krina T. (2012). Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes. Plos Genetics, 8 (2), e1002505−e1002505.
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Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N ... Sladek, Robert (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE, 7 (1), e29202−e29202.
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2012
Mägi, R; Morris, AP. (2012). Genome-wide association analysis of rare variants identifies potential novel susceptibility genes for type 1 diabetes and coronary artery disease. ANNALS OF HUMAN GENETICS, 76: European Mathematical Genetics Meeting, Gottingen, GERMANY, APR 12-13, 2012. Wiley-Blackwell, 421−422.
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2012
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2012
Dimas, A.S.; Gomes, V.I.; Knowles, J.; Mägi, R.; Barker, A.; Hivert, M.-F.; Benazzo, A.; Rybin, D.; Assimes, T.I.; Ouertermous, T.; Walker, M.; Florez, J.C.; Barroso, I.; Langenberg, Cl.; Dupuis, J.; Watanabe, R.; McCarthy, M.; Ingelsson, E.; Prokopenko, I. (2012). Impact of Type 2 Diabetes Susceptibility Loci on Variation in Physiologic Glycaemic Traits in Non-Diabetic Individuals. Circulation, 126: AHA Scientific Session 2012, Los Angeles, USa, 3-7. Nov.. Lippincott Williams & Wilkins, 14977. (21).
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2011
Bailey-Wilson, JE.; Brennan, JS.; Bull, SB.; Culverhouse, R.; Kim, Y.; Jiang, Y.; Jung, JS.; Li, Q.; Lamina, C.; Liu, Y.; Magi, R.; Niu, YS.; Simpson, CL.; Wang, LB.; Yilmaz, YE.; Zhang, HP.; Zhang, ZG. (2011). Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data. Genetic Epidemiology, 35, S92−S100.
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2011
Chambers, JC; Zhang, WH; Sehmi, J; Li, XZ; Wass, MN; Van der Harst, P; Holm, H; Sanna, S; Kavousi, M; Baumeister, SE; Coin, LJ; Deng, GH; Gieger, C; Heard-Costa, NL; et, al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43 (11), 1131−1138.10.1038/ng.970.
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2011
Gieger, C; Radhakrishnan, A; Cvejic, A; Tang, WH; Porcu, E; Pistis, G; Serbanovic-Canic, J; Elling, U; Goodall, AH; Labrune, Y; Lopez, LM; Magi, R; Meacham, S; Okada, Y; Pirastu, N; Sorice, R; Teumer, A; Voss, K; Zhang, WH; Ramirez-Solis, R ... Soranzo, N (2011). New gene functions in megakaryopoiesis and platelet formation. Nature, 480 (7376), 201−208.
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2011
Metspalu, M.; Romero, IG.; Yunusbayev, B.; Chaubey, G.; Mallick, CB.; Hudjashov, G.; Nelis, M.; Mägi, R.; Metspalu, E.; Remm, M.; Pitchappan, R.; Singh, L.; Thangaraj, K.; Villems, R.; Kivisild, T. (2011). Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia. American Journal of Human Genetics, 89 (6), 731−44.10.1016/j.ajhg.2011.11.010.
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Strawbridge, RJ; Dupuis, J; Prokopenko, I; Barker, A; Ahlqvist, E; Rybin, D; Petrie, JR; Travers, ME; Bouatia-Naji, N; Dimas, AS; Nica, A; Wheeler, E; Chen, H; Voight, BF; Taneera, J; Kanoni, S; Peden, JF; Turrini, F; Gustafsson, S; Zabena, C ... Florez, JC. (2011). Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes, 60 (10), 2624−2634.10.2337/db11-0415.
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Zhu, H.; Shyh-Chang, N.; Segrè, AV.; Shinoda, G.; Shah, SP.; Einhorn, WS.; Takeuchi, A.; Engreitz, JM.; Hagan, JP.; Kharas, MG.; Urbach, A.; Thornton, JE.; Triboulet, R.; Gregory, RI.; DIAGRAM, Consortium; MAGIC, Investigators; Altshuler, D.; Daley, GQ. (2011). The Lin28/let-7 axis regulates glucose metabolism. Cell, 147 (1), 81−94.
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2011
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2011
Speliotes, EK; Yerges-Armstrong, LM; Wu, J; Hernaez, R; Kim, LJ; Palmer, CD; Gudnason, V; Eiriksdottir, G; Garcia, ME; Launer, LJ; Nalls, MA; Clark, JM; Mitchell, BD; Shuldiner, AR; NASH, CRN; GIANT, Consortium; MAGIC, Investigators; GOLD, Consortium (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. Plos Genetics, 7 (3), e1001324.10.1371/journal.pgen.1001324.
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2011
Kilpelaeinen, TO; den Hoed, M; Ong, KK; Grontved, A; Brage, S; Jameson, K; Cooper, C; Khaw, KT; Ekelund, U; Wareham, NJ; Loos, RJF; Early Growth Genetics Consortium, incl. Magi R (2011). Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 (4), 851−860.
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2011
The International Consortium for Blood Pressure Genome-Wide Association Studies, incl. Sõber, S.; Snieder, H.; Org, E.; Veldre, G.; Viigimaa, M.; Laan, M. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478 (7367), 103−109.10.1038/nature10405.
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2011
Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Johnson, A.D.; Bochud, M.; Rice, K.M.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C. ... Metspalu, A. et al (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics, 43, 1005−1011.10.1038/ng.922.
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Yang, J.; Weedon, M.N.; Purcell, S.; Lettre, G.; Estrada, K.; Willer, C.J.; Smith, A.V.; Ingelsson, E.; O'Connell, J.R.; Mangino, M.; Mägi, R.; Madden, P.A.; Heath, A.C.; Nyholt, D.R.; Martin, N.G.; Montgomery, G.W.; Frayling, T.M.; Hirschhorn, J.N.; McCarthy, M.I.; Goddard, M.E. ... Visscher, P.M. (2011). Genomic inflation factors under polygenic inheritance. European Journal of Human Genetics, 19, 807−812.10.1038/ejhg.2011.39.
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2011
Sulem, P.; Gudbjartsson, D. F.; Geller, F.; Prokopenko, I.; Feenstra, B.; Aben, K.K.H.; Franke, B.; den Heijer, M.; Kovacs, P.; Stumvoll, M.; Mägi, R.; Yanek, L.R.; Becker, L.C.; Boyd, H.A.; Stacey, S.N.; Bragi Walters, G.; Jonasdottir, A.; Thorleifsson, G.; Holm, H.; Gudjonsson, S.A. ... Stefansson, K. (2011). Sequence variants at CYP1A1–CYP1A2 and AHR associate with coffee consumption. Human Molecular Genetics, 20 (10), 2071−2077.
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Böger, CA; Chen, MH; Tin, A; Olden, M; Köttgen, A; de Boer, IH; Fuchsberger, C; O’Seaghdha, CM; Pattaro, C; Teumer, A; et, al. (2011). CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology, 22, 555−570.
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2011
Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
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2011
Mägi, R.; Kumar, A.; Morris, AP. (2011). Assessing the impact of missing genotype data in rare variant association analysis. BMC Proceedings, 9 (5), S107−S107.
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Speliotes, E.K.; Willer, C.J.; Berndt, S.I.; Monda, K.L.; Thorleifsson, G.; Jackson, A.U.; Allen, H.L.; Lindgren, C.M.; Luan, J.; Mägi, R.; Randall, J.C.; Vedantam, S.; Winkler, T.W.; Workalemahu, T.; Heid, I.M.; Qi, L.; Steinthorsdottir, V.; Weedon, M.N.; Wheeler, E.; Wood, A.R. ... Hayward, C. (2010). Genome-wide association study of 249,796 individuals reveals eighteen loci associated with body mass index. Nature Genetics, 11, 937−948.10.1038/ng.686.
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Soranzo, Nicole; Sanna, Serena; Wheeler, Eleanor; Gieger, Christian; Radke, Dörte; Dupuis, Josée; Bouatia-Naji, Nabila; Langenberg, Claudia; Prokopenko, Inga; Stolerman, Elliot; Sandhu, Manjinder S; Heeney, Matthew M; Devaney, Joseph M; Reilly, Muredach P; Ricketts, Sally L; Stewart, Alexandre FR; Voight, Benjamin F; Willenborg, Christina; Wright, Benjamin; Altshuler, David ... Meigs, James B (2010). Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes, 59 (12), 3229−3239.10.2337/db10-0502.
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Mägi, Reedik; Lindgren, Cecilia M.; Morris, Andrew P. (2010). Meta-analysis of sex-specific genome-wide association studies. Genetic Epidemiology, 34 (8), 846−853.10.1002/gepi.20540.
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1.1.
2010
Oitmaa, E.; Peters, M.; Vaidla, K.; Andreson, R.; Mägi, R.; Slavin, G.; Velthut, .; Tõnisson, N.; Reimand, T.; Remm, M.; Schneider, M.; Õunap, K.; Salumets, A.; Metspalu, A. (2010). Molecular diagnosis of Down Syndrome using Quantitative APEX-2 microarrays. Prenatal Diagnosis, 30, 1170−1177.
1.1.
2010
Dupuis, J.; Langenberg, C.; Prokopenko, I.; Saxena, R.; Soranzo, N.; Jackson, A.U.; Wheeler, E.; Glazer, N.L.; Bouatia-Naji, N.; Gloyn, A.L.; Lindgren, C.M.; Mägi, R.; Morris, A.P.; Randall, J.; Johnson, T.; Elliott, P.; Rybin, D.; Thorleifsson, G.; Steinthorsdottir, V.; Henneman, P. ... Mitchell, B.D (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42 (2), 105−116.10.1038/ng.520.
1.1.
2010
Mägi, R; Morris, AP. (2010). GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics, 11 (288), 288.10.1186/1471-2105-11-288.
1.1.
2010
Ingelsson, E.; Langenberg, C.; Hivert, M.F.; Prokopenko, I.; Lyssenko, V.; Dupuis, J.; Mägi, R.; Sharp, S.; Jackson, A.U.; Assimes, T.L.; Shrader, P.; Knowles, J.W.; Zethelius, B.; Abbasi, F.A.; Bergman, R.N.; Bergmann, A.; Berne, C.; Boehnke, M.; Bonnycastle, L.L.; Bornstein, S.R. ... Florez, JC. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. DIABETES, 59: 59th Annual Meeting of the American-Society-of-Human-Genetics; Honolulu, HI, USA; OCT 20-24, 2009. 1266−1275. (5).10.2337/db09-1568.
1.1.
2010
Freathy, R.M.; Mook-Kanamori, D.O.; Sovio, U.; Prokopenko, I.; Timpson, N.J.; Berry, D.J.; Warrington, N.M.; Widen, E.; Hottenga, J.J.; Kaakinen, M.; Lange, L.A.; Bradfield, J.P.; Kerkhof, M.; Marsh, J.A.; Mägi, R.; et, al. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 (5), 430−435.
1.1.
2010
Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; et, al.; Mägi, R.; et, al. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42 (5), 376−384.10.1038/ng.568.
1.1.
2010
Thorgeirsson, TE.; Gudbjartsson, DF.; Surakka, I.; Vink, JM.; Amin, N.; Geller, F.; Sulem, P.; Rafnar, T.; Esko, T.; Walter, S.; Gieger, C.; Rawal, R.; Mangino, M.; Prokopenko, I.; Mägi, R.; Keskitalo, K.; Gudjonsdottir, IH.; Gretarsdottir, S.; Stefansson, H.; Thompson, JR. ... Stefansson, K (2010). Sequence variants at CHRNB3-CHRNA6 and affect smoking behavior. Nature Genetics, 42 (5), 448−453.
5.1.
2010
Mägi, R.; Hottenga, J. J.; Prokopenko, I. (2010). A genome-wide association analysis of over 75,000 individuals identifies gender-specific effects for fasting glycaemic traits. Diabetologia, 53: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, SWEDEN, SEP 20-24, 2010. Springer, S28−S28.
5.1.
2010
Mägi, R; Morris, AP. (2010). GRANVIL: Rare Variant Analysis of Genome-Wide Association Studies. Genetic Epidemiology, 34: 19th Annual Meeting of the International-Genetic-Epidemiology-Society, Boston, MA, OCT 10-12, 2010. Wiley-Blackwell, 926−926. (8).
1.1.
2009
Nelis, M.; Esko, T.; Mägi, R.; Zimprich, F.; Zimprich, A.; Toncheva, D.; Karachanak, S.; Piskácková, T.; Balascák, I.; Peltonen, L.; Jakkula, E.; Rehnström, K.; Lathrop, M.; Heath, S.; Galan, P.; Schreiber, S.; Meitinger, T.; Pfeufer, A.; Wichmann, HE.; Melegh, B. ... Metspalu, A. (2009). Genetic structure of Europeans: a view from the North-East. PLoS ONE, 4(5), e5472.
5.1.
2009
Prokopenko, I; Dupuis, J; Langenberg, C; Saxena, R; Soranzo, N; Jackson, AU; Wheeler, E; Glazer, NL; Mägi, R; Bouatia-Naji, N; Florez, JC; Barroso, I. (2009). Novel genetic loci implicated in fasting glucose homeostasis and their impact on related metabolic traits. Diabetologia, 52: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, AUSTRIA, SEP 30-OCT 02, 2009.. Springer, S38−S38.
1.1.
2008
Krjutskov, K.; Andreson, R.; Mägi, R.; Nikopensius, T.; Khrunin, A.; Mihailov, E.; Tammekivi, V.; Sork, H.; Remm, M.; Metspalu, A. (2008). Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays. Nucleic Acids Research, 36 (12), e75.
1.1.
2008
Tamm, R.; Oselin, K.; Kallassalu, K.; Magi, R.; Anier, K.; Remm, M.; Metspalu, A. (2008). Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population. Clinical Chemistry and Laboratory Medicine, 46 (7), 974−979.
5.2.
2008
Oitmaa, Eneli; Krjutskov, Kaarel; Mägi, Reedik ; Andreson, Reidar ; Raukas, Elve; Remm, Maido; Tõnisson, Neeme; Schneider, Marion; Metspalu, Andres (2008). Molecular diagnostics of Down syndrome using quantitative APEX microarrays. RBM online, vol.16-suppl. 3: Eighth International Symposium of Preimplantation Genetic Diagnosis, Barcelona, April 23-26, 2008. S17.
1.1.
2007
Magi, R.; Pfeufer, A.; Nelis, M.; Montpetit, A.; Metspalu, A.; Remm, M. (2007). Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. BMC Genomics, 8 (159), x.
1.1.
2007
Kuningas, M.; Mägi, R.; Westendorp, R.G.; Slagboom, P.E.; Remm, M.; van Heemst, D. (2007). Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. European Journal of Human Genetics, 15 (3), 294−301.10.1038/sj.ejhg.5201766.
1.1.
2006
Kaminski, S.; Brym, P.; Rusc, A.; Wojcik, E.; Ahman, A.; Mägi, R. (2006). Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (APEX) microarray. Animal biotechnology, 17 (1), 1−11.
1.1.
2006
Montpetit, A.; Nelis, M.; Laflamme, P.; Magi, R.; Ke, X.Y.; Remm, M.; Cardon, L.; Hudson, T.J.; Metspalu, A. (2006). An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. Plos Genetics, 2 (3), 282−290.
3.2.
2006
Mägi, R.; Kaplinski, L.; Remm, M. (2006). The Whole Genome TagSNP Selection and Transferability Among HapMap Populations. Pacific Symposium on Biocomputing 2006: 2006. World Scientific Publ Co Pte Ltd, 535−543.
1.1.
2005
Mueller, J. C.; Lõhmussaar, E.; Mägi, R.; Remm, M.; Bettecken, T.; Lichtner, P.; Huber, S.; Illig, T; Luedemann, J.; Schreiber, S.; Wichmann, H. E.; Pramstaller, P.; Romeo, G.; Testa, A.; Metspalu, A.; Meitinger, T. (2005). Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations. American Journal of Human Genetics, 76 (3), 387−398.
1.1.
2002
Liira, J.; Zobel, K.; Magi, R.; Molenberghs, G. (2002). Vertical structure of herbaceous canopies: the importance of plant growth-form and species-specific traits. Plant Ecology, 163 (1), 123−134.
1.1.
2002
Dawson, E.; Abecasis, GR.; Bumpstead, S.; Chen, Y.; Hunt, S.; Beare, DM.; Pabial, J.; Dibling, T.; Tinsley, E.; Kirby, S.; Carter, D.; Papaspyridonos, M.; Livingstone, S.; Ganske, R.; Lohmmussaar, E.; Zernant, J.; Tonisson, N.; Remm, M.; Magi, R.; Puurand, T. ... Dunham, I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature, 418 (6897), 544−548.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using APEX arrays. European Journal of Human Genetics, 10, 299−299.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Puurano, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using Arrayed Primer EXtension (APEX) technology. American Journal of Human Genetics, 71 (4), 449−449.
5.1.
2001
Metspalu, A.; Zernant, J.; Lohmussaar, E.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, L.; Pavel, H.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M. (2001). SNP analysis of the human chromosome 22 using APEX arrays. American Journal of Human Genetics, 69 (4), 408−408.

Industrial property

3.06.2019
Detailne otsing
  • Leitud 14 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0180026s09Bioinformaatika rakendamine genoomijärjestuste uurimiseks 01.01.200931.12.2014Maido RemmTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond546 107,92 EUR
2.2.1.VP1GV17047Epidemioloogiline uuring toitainete ja rasvumise rolli tuvastamiseks atoopilise dermatiidi ja akne puhul01.09.201731.12.2018Reedik MägiTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu70 463,52 EUR
SFSF0180142Cs08Geneetiline varieeruvus, elustiil ja keskkonnategurid kui peamised tervise mõjurid - EGV01.01.200831.12.2013Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu459 958,57 EUR
TKSLTMR16142T (TK142)Genoomika ja Siirdemeditsiini Tippkeskus (TK142)01.01.201601.03.2023Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu4 474 349,50 EUR
SFSF0182649s04Inimese genoomi haplotüüpse struktuuri analüüs (0182649s04)01.01.200431.12.2008Maido RemmTartu Ülikool, Bioloogia-geograafiateaduskond224 329,88 EUR
ETFETF6041Konserveerunud järjestuselementide detekteerimine eukarüootsetes genoomides võrdleva genoomika abil01.01.200531.12.2006Maido RemmEesti Biokeskus12 910,15 EUR
PRGPRG243Looduslik valik ja migratsioonid inimese geneetilise varieeruvuse kujunemisel Ida Euroopa lauskmaal. Vana-DNA uurimus01.01.201831.12.2022Mait MetspaluTartu Ülikool, Tartu Ülikooli genoomika instituut399 862,50 EUR
MUUVP1GV13124Metaboloomika ja genoomika uuring kehakaalu mõjutavate faktorite identifitseerimiseks05.07.201331.12.2016Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu810 800,00 EUR
MUUSBGMR06013Mobiilsustoetus Pacific Sypmosium of Biocomputing01.01.200611.01.2006Reedik MägiTartu Ülikool1 278,23 EUR
IUTIUT20-60Oomiksi põhised meetodid terviseuuringutes: integreeritud lähenemine haiguste tekkeprotsesside mõistmiseks ja prognoosimiseks01.01.201431.12.2019Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu; Tartu Ülikool, Tartu Ülikooli genoomika instituut1 327 800,00 EUR
MUUSP1GV15007TPersonaalse meditsiini pilootprojekt "Eestlaste genoomivarieeruvuse andmebaasi loomine"01.01.201531.08.2015Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu1 740 042,00 EUR
ETFETF9353Põhjuslike seoste analüüsi metoodika uuringutes mis kasutavad tavalist või Mendeli randomiseerimist01.01.201231.12.2015Krista FischerTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu60 000,00 EUR
MUUSP1GVARENGSiirdegenoomika keskus01.01.201131.12.2015Ursel Soomets; Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu3 500 000,00 EUR
1.2.3.4.; MUUMLTMR15148R (H2020-TWINN-2015 WIDENLIFE project #692056)WIDENLIFE01.01.201631.12.2018Ants KurgTartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut455 380,00 EUR