Reedik Mägi

https://www.etis.ee/CV/Reedik_Mägi/est
18.08.1978
737 4045
reedik.magi@ut.ee

Teenistuskäik

Töökohad ja ametid
19.08.2019–...   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, bioinformaatika juhtivteadur (1,00)
01.01.2018–18.08.2019   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, bioinformaatika vanemteadur (1,00)
01.09.2016–31.12.2017   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, bioinformaatika vanemteadur (1,00)
01.09.2011–31.08.2016   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, statistilise geneetika vanemteadur (1,00)
01.02.2010–31.08.2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, teadur (0,10)
2009–2011   
University Of Oxford, Marie Curie Research Fellow in Wellcome Trust Centre for Human Genetics (1,00)
01.09.2008–31.08.2011   
Eesti Biokeskus, Erakorraline teadur (0,10)
01.04.2008–31.01.2010   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, erakorraline teadur (0,10)
2008–2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, Bioinformaatika õppetool, Erakorraline teadur (0,10)
2008–2009   
University Of Oxford, Senior Statistical Geneticist (1,00)
01.01.2008–31.12.2011   
Wellcome Trust Centre for Human Genetics, Univeristy of Oxford; postdok
01.01.2008–31.03.2008   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, erakorraline teadur (1,00)
01.12.2007–31.12.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.08.2007–30.11.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,10)
01.02.2007–31.07.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.09.2006–31.01.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.07.2006–31.08.2006   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.09.2005–30.06.2006   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.07.2005–31.08.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.02.2005–30.06.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.02.2004–31.01.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
2004–2008   
Tartu Ülikool, Tartu Ülikool, erak. teadur (0,50)
01.01.2002–2004   
OÜ Biodata, OÜ Biodata, IT spetsialist (0,50)
01.01.2000–31.12.2002   
AS Asper Biotech, IT spetsialist
 
 
Haridustee
2003–2007   
Tartu Ülikool bioinformaatika eriala doktoriõpe
2000–2003   
Tartu Ülikool taimeökoloogia eriala magistriõpe
1996–2000   
Tartu Ülikool botaanika ja ökoloogia eriala bakalaureuseõpe
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2016−...   
Igaaastase kursuse "Introduction to the statistical analysis of genome-wide association studies" Imperial College of London, UK kaasjuht
2017−2017   
Konverentsi "European Mathematical Genetics Meeting" organiseerija ja teaduskomitee liige

Kvalifikatsioon

Teaduskraadid
Reedik Mägi, doktorikraad, 2007, (juh) Maido Remm, The Linkage Disequilibrium And The Selection of Genetic markers For Association Studies in European Populations, Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut.
Reedik Mägi, magistrikraad (teaduskraad), 2003, (juh) Kristjan Zobel, Rohu- ja puhmarinde võra struktuur 27 Eesti niidu- ja metsakoosluses, Tartu Ülikool, Bioloogia-geograafiateaduskond, Botaanika ja ökoloogia instituut.
 
 
Teaduspreemiad ja tunnustused
2019, Reedik Mägi, Riigi teaduspreemia keemia ja molekulaarbioloogia alal teadustöö „Geneetika- ja genoomikaalased alusuuringud personaalmeditsiini rakendamiseks Eestis“ eest (Esko, Mägi, Fischer, Milani)
2009, Reedik Mägi, EC FP7 Marie Curie IEF (2009-2011)
2008, Reedik Mägi, Järeldoktorantuuri grant Eesti Biokeskusest (ECOGENE)
 
 
Teadustöö põhisuunad
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin; CERCS ERIALA: B100 Biomeditsiini ajalugu ja filosoofia, teoreetiline bioloogia, evolutsiooni üldised küsimused ; PÕHISUUND: Main scientific interests include population and statistical genetics, as well as software development for implementing statistical methods for genetic studies. I have worked on the development and implementation of methodology of meta-analysis, rare-variant analysis, and sequencing data analysis. I am also participating in several association studies, which are mainly related to T2D and various anthropometric phenotypes.

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F; Feufer, Arne P; Marullo, Letizia; Mägi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in medicine.10.2217/bmm-2017-0431 [ilmumas].
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in medicine, 1−8.10.1038/s41436-018-0311-2 [ilmumas].
1.1.
2019
Reisberg, Sulev; Galwey, Nicholas; Avillach, Paul; Sahlqvist, Anna-Stina; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Vilo, Jaak; James, Glen (2019). Comparison of variation in frequency for SNPs associated with asthma or liver disease between Estonia, HapMap populations and the 1000 genome project populations. International Journal of Immunogenetics, 46 (1), 1−10.10.1111/iji.12413.
1.1.
2019
Tasa, T.; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 27 (3), 442−454.10.1038/s41431-018-0300-6.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, in press.10.1111/eva.12780 [ilmumas].
1.1.
2019
de Vries, Paul S; Brown, Michael R; Bentley, Amy R; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C (2019). Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology.10.1093/aje/kwz005 [ilmumas].
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648.10.1038/s41588-019-0378-y.
1.1.
2019
Saag, Lehti; Laneman, Margot; Varul, Liivi; Malve, Martin; Valk, Heiki; Razzak, Maria A.; Shirobokov, Ivan G.; Khartanovich, Valeri I.; Mikhaylova, Elena R.; Kushniarevich, Alena; Scheib, Christiana Lyn; Solnik, Anu; Reisberg, Tuuli; Parik, Juri; Saag, Lauri; Metspalu, Ene; Rootsi, Siiri; Montinaro, Francesco; Remm, Maido; Magi, Reedik ... Tambets, Kristiina (2019). The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East. Current Biology, 29 (10), 1701−1728.10.1016/j.cub.2019.04.026.
1.1.
2019
Justice, Anne E; Karaderi, Tugce; Highland, Heather M; Young, Kristin L; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L; Fine, Rebecca S; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W; Locke, Adam E; Medina-Gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush ... Lindgren, Cecilia M (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51 (3), 452−469.10.1038/s41588-018-0334-2.
1.1.
2019
Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; ,; ,; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D ... Vrieze, Scott (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51 (2), 237−244.10.1038/s41588-018-0307-5.
1.1.
2019
Bovijn, Jonas; Jackson, Leigh; Censin, Jenny; Chen, Chia-Yen; Laisk, Triin; Laber, Samantha; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Smoller, Jordan W; Harrison, Jamie W; Ruth, Katherine S; Beaumont, Robin N; Jones, Samuel E; Tyrrell, Jessica; Wood, Andrew R; Weedon, Michael N; Mägi, Reedik; Neale, Benjamin; Lindgren, Cecilia M ... Holmes, Michael V (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104 (1), 157−163.10.1016/j.ajhg.2018.11.004.
1.1.
2019
Wiberg, Akira; Ng, Michael; Schmid, Annina B.; Smillie, Robert W.; Baskozos, Georgios; Holmes, Michael V.; Kunnapuu, K.; Magi, R.; Bennett, David L.; Furniss, Dominic (2019). A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nature Communications, 10, ARTN 1030.10.1038/s41467-019-08993-6.
1.1.
2019
James, Glen; Reisberg, Sulev; Lepik, Kaido; Galwey, Nicholas; Avillach, Paul; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Alexander, Myriam; Waterworth, Dawn; Loomis, A. Katrina; Vilo, Jaak (2019). An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank. PLOS ONE, 14 (4), e0215026.10.1371/journal.pone.0215026.
1.1.
2019
Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B.; Feitosa, Mary F.; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y.; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O.; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar ... Pattaro, Cristian (2019). A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51 (6), 957−976.10.1038/s41588-019-0407-x.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
1.1.
2018
Pervjakova, N.; Kukushkina, V.; Haller, T.; Kasela, S.; Joensuu, A.; Kristiansson, K.; Annilo, T.; Perola, M.; Salomaa, V.; Jousilahti, P.; Metspalu, A.; Magi, R. (2018). Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene. Biomarkers in medicine, 12 (5), 439−446.10.2217/bmm-2018-0020.
1.1.
2018
Suhorutshenko, Marina; Kukushkina, Viktorija; Velthut-Meikas, Agne; Altmäe, Signe; Peters, Maire; Mägi, Reedik; Krjutškov, Kaarel; Koel, Mariann; Codoñer, Francisco; Martinez-Blanch, Juan; Vilella, Felipe; Simón, Carlos; Salumets, Andres; Laisk, Triin (2018). Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. Human Reproduction, 33 (11), 2074−2086.10.1093/humrep/dey301.
1.1.
2018
Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
1.1.
2018
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
1.1.
2018
Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. Jornal Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
1.1.
2018
Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516.10.1038/s41588-018-0241-6.
1.1.
2018
Pasman, Joëlle A; Verweij, Karin J H; Gerring, Zachary; Stringer, Sven; Sanchez-Roige, Sandra; Treur, Jorien L; Abdellaoui, Abdel; Nivard, Michel G; Baselmans, Bart M L; Ong, Jue-Sheng; Ip, Hill F; van der Zee, Matthijs D; Bartels, Meike; Day, Felix R; Fontanillas, Pierre; Elson, Sarah L; ,; de Wit, Harriet; Davis, Lea K; MacKillop, James ... Vink, Jacqueline M (2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21 (9), 1161−1170.10.1038/s41593-018-0206-1.
1.1.
2018
Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429.10.1038/s41588-018-0205-x.
1.1.
2018
Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571.10.1038/s41588-018-0084-1.
3.1.
2018
Vals, M.A.; Pajusalu, S.; Kals, M.; Mägi, R.; Õunap, K. (2018). The Prevalence of PMM2-CDG in Estonia Based on Population Carrier Frequencies and Diagnosed Patients. JIMD Reports, 39, 13−17.10.1007/8904_2017_41.
6.8.
2018
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez ... McCarthy, Mark I (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5, 180002−180002.10.1038/sdata.2018.2.
6.8.
2018
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael ... Caulfield, Mark J (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (12), 1755−1755.10.1038/s41588-018-0297-3.
1.1.
2017
Huan, Tianxiao; Joehanes, Roby; Schurmann, Claudia; Schramm, Katharina; Pilling, Luke C; Peters, Marjolein J; Mägi, Reedik; DeMeo, Dawn; O'Connor, George T; Ferrucci, Luigi; Teumer, Alexander; Homuth, Georg; Biffar, Reiner; Völker, Uwe; Herder, Christian; Waldenberger, Melanie; Peters, Annette; Zeilinger, Sonja; Metspalu, Andres; Hofman, Albert ... Levy, Daniel (2017). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics, 25 (21), 1−33.10.1093/hmg/ddw288.
1.1.
2017
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201.10.1038/mp.2016.71.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 114 (3), E327−E336.10.1073/pnas.1619052114.
1.1.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 3, 403−415.10.1038/ng.3768.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110.10.1186/s12859-017-1530-2.
1.1.
2017
Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25.10.1186/s12859-016-1437-3.
1.1.
2017
R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical pharmacology and therapeutics, 101 (5), 684−695.10.1002/cpt.540.
1.1.
2017
Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186.10.1038/ng.3912.
1.1.
2017
Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. Plos Genetics, 13 (6), e1006812.10.1371/journal.pgen.1006812.
1.1.
2017
Kukushkina, Viktorija; Modhukur, Vijayachitra; Suhorutšenko, Marina; Peters, Maire; Mägi, Reedik; Rahmioglu, Nilufer; Velthut-Meikas, Agne; Altmäe, Signe; Esteban, Francisco J; Vilo, Jaak; Zondervan, Krina; Salumets, Andres; Laisk-Podar, Triin (2017). DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase. Scientific Reports, 7 (1), 3916−3916.10.1038/s41598-017-03682-0.
1.1.
2017
Eichstaedt, Christina A; Pagani, Luca; Antao, Tiago; Inchley, Charlotte E; Cardona, Alexia; Mörseburg, Alexander; Clemente, Florian J; Sluckin, Timothy J; Metspalu, Ene; Mitt, Mario; Mägi, Reedik; Hudjashov, Georgi; Metspalu, Mait; Mormina, Maru; Jacobs, Guy S; Kivisild, Toomas (2017). Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations. Scientific Reports, 7 (1), 13042−13042.10.1038/s41598-017-13382-4.
1.1.
2017
Kraja, Aldi T.; Cook, James P.; Warren, Helen R.; Surendran, Praveen; Liu, Chunyu; Evangelou, Evangelos; Manning, Alisa K.; Grarup, Niels; Drenos, Fotios; Sim, Xueling; Smith, Albert Vernon; Amin, Najaf; Blakemore, Alexandra I. F.; Bork-Jensen, Jette; Brandslund, Ivan; Farmaki, Aliki-Eleni; Fava, Cristiano; Ferreira, Teresa; Herzig, Karl-Heinz; Giri, Ayush ... Howson, Joanna M. M. (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals. Circulation-cardiovascular Genetics, 10 (5), UNSP e001778.10.1161/CIRCGENETICS.117.001778.
1.1.
2017
Mägi, R; Horikoshi, M; Sofer, T; Mahajan, A; Kitajima, H; Franceschini, N; McCarthy, MI; COGENT-Kidney, Consortium; T2D-GENES, Consortium; Morris, AP (2017). Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Human Molecular Genetics, 26 (18), 3639−3650.10.1093/hmg/ddx280.
1.1.
2017
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N. William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez ... McCarthy, Mark I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, ARTN 170179.10.1038/sdata.2017.179.
1.1.
2017
Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish; Emdin, Connor; Alam, Dewan; Alves, Alexessander Couto; Amouyel, Philippe; Di Angelantonio, Emanuele; Arveiler, Dominique; Assimes, Themistocles L.; Auer, Paul L.; Baber, Usman; Ballantyne, Christie M.; Bang, Lia E.; Benn, Marianne; Bis, Joshua C. ... Kathiresan, Sekar (2017). Exome-wide association study of plasma lipids in > 300,000 individuals. Nature Genetics, 49 (12), 1758−1772.10.1038/ng.3977.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994.10.1038/ejhg.2017.90.
1.1.
2017
Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung ... Lindgren, Cecilia M. (2017). A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 66 (7), 2019−2032.10.2337/db16-1329.
1.1.
2017
Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845.10.1038/ng.3841.
1.1.
2017
Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D. ... Kilpelainen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults. PLOS Genetics, 13 (4), ARTN e1006528.10.1371/journal.pgen.1006528.
1.1.
2017
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stančáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179.10.1038/sdata.2017.179.
1.1.
2017
Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia; Gaulton, Kyle J.; Kaakinen, Marika; Pervjakova, Natalia; Pers, Tune H.; Johnson, Andrew D.; Eicher, John D.; Jackson, Anne U.; Ferreira, Teresa; Lee, Yeji; Ma, Clement; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Van Zuydam, Natalie R.; Mahajan, Anubha; Chen, Han ... Prokopenko, Inga (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes, 66 (11), 2888−2902.10.2337/db16-1253.
1.1.
2017
Mitt, Mario; Kals, Mart; Parn, Kalle; Gabriel, Stacey B; Lander, Eric S; Palotie, Aarno; Ripatti, Samuli; Morris, Andrew P; Metspalu, Andres; Esko, Tonu; Magi, Reedik; Palta, Priit; (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. European Journal of Human Genetics, 25 (7), 869−879.10.1038/ejhg.2017.51.
5.1.
2017
Rahmioglu, Nilufer; Lockstone, Helen; Ferreira, Teresa; Magi, Reedik; Van De Bunt, Martijn; Lindgren, Cecilia; Morris, Andrew; Becker, Christian; Zondervan, Krina (2017). Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis. Reproductive Sciences, 24, 205A−206A.
5.1.
2017
Kaakinen, Marika; Magi, Reedik; Lagou, Vasiliki; Claringbould, Annique; Gaulton, Kyle; Fischer, Krista; Morris, Andrew; Prokopenko, Inga (2017). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. Genetic Epidemiology, 41 (7), 652−653.
5.1.
2017
Suhorutshenko, M.; Kukushkina, V.; Velthut-Meikas, A.; Altmae, S.; Maire, P.; Magi, R.; Codoner, F.; Vilella, F.; Simon, C.; Salumets, A.; Laisk-Podar, T. (2017). Transcriptomic profile of early and mid-secretory endometrium revealed by RNA-seq: a paired sample cohort study. FEBS Journal, 284, 134−134.
6.8.
2017
Teumer, A.; Qi, Q.; Nethander, M.; Aschard, H.; Bandinelli, S.; Beekman, M.; Berndt, S. I.; Bidlingmaier, M.; Broer, L.; Cappola, A.; Ceda, G. P.; Chanock, S.; Chen, M. -H.; Chen, T. C.; Chen, Y. -D. I.; Chung, J.; Miglianico, Del Greco F.; Eriksson, J.; Ferrucci, L.; Friedrich, N. ... Kaplan, R. C. (2017). Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016). Aging Cell, 16 (4), 898−898.10.1111/acel.12612.
6.8.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Elliott, Paul (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (vol 49, pg 403, 2017). Nature Genetics, 49 (10), 1558−1558.10.1038/ng1017-1558a.
1.1.
2016
Stringer, S; Minică, C C; Verweij, K J H; Mbarek, H; Bernard, M; Derringer, J; van Eijk, K R; Isen, J D; Loukola, A; Maciejewski, D F; Mihailov, E; van der Most, P J; Sánchez-Mora, C; Roos, L; Sherva, R; Walters, R; Ware, J J; Abdellaoui, A; Bigdeli, T B; Branje, S J T ... Vink, J M (2016). Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Translational Psychiatry, 6, e769−e769.10.1038/tp.2016.36.
1.1.
2016
Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroula ... Loos, Ruth J F (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7, 10495−10495.10.1038/ncomms10495.
1.1.
2016
Lessard, Samuel; Manning, Alisa K; Low-Kam, Cécile; Auer, Paul L; Giri, Ayush; Graff, Mariaelisa; Schurmann, Claudia; Yaghootkar, Hanieh; Luan, Jian'an; Esko, Tonu; Karaderi, Tugce; Bottinger, Erwin P; Lu, Yingchang; Carlson, Chris; Caulfield, Mark; Dubé, Marie-Pierre; Jackson, Rebecca D; Kooperberg, Charles; McKnight, Barbara; Mongrain, Ian ... Lettre, Guillaume (2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. Human Molecular Genetics, 25 (10), 1−11.10.1093/hmg/ddw055.
1.1.
2016
Pervjakova, Natalia; Kasela, Silva; Morris, Andrew P; Kals, Mart; Metspalu, Andres; Lindgren, Cecilia M; Salumets, Andres; Mägi, Reedik (2016). Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues. Epigenomics, 8 (6), 789−799.10.2217/epi.16.8.
1.1.
2016
Okbay, Aysu; Beauchamp, Jonathan P; Fontana, Mark Alan; Lee, James J; Pers, Tune H; Rietveld, Cornelius A; Turley, Patrick; Chen, Guo-Bo; Emilsson, Valur; Meddens, S Fleur W; Oskarsson, Sven; Pickrell, Joseph K; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; Ahluwalia, Tarunveer S; Bacelis, Jonas; Baumbach, Clemens; Bjornsdottir, Gyda ... Benjamin, Daniel J (2016). Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533 (7604), 539−542.10.1038/nature17671.
1.1.
2016
Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P; Manning, Alisa K; Grarup, Niels; Sim, Xueling; Barnes, Daniel R; Witkowska, Kate; Staley, James R; Tragante, Vinicius; Tukiainen, Taru; Yaghootkar, Hanieh; Masca, Nicholas; Freitag, Daniel F; Ferreira, Teresa; Giannakopoulou, Olga; Tinker, Andrew; Harakalova, Magdalena ... Munroe, Patricia B (2016). Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics, 48 (10), 1151−1161.10.1038/ng.3654.
1.1.
2016
Tajuddin, Salman M; Schick, Ursula M; Eicher, John D; Chami, Nathalie; Giri, Ayush; Brody, Jennifer A; Hill, W David; Kacprowski, Tim; Li, Jin; Lyytikäinen, Leo-Pekka; Manichaikul, Ani; Mihailov, Evelin; O'Donoghue, Michelle L; Pankratz, Nathan; Pazoki, Raha; Polfus, Linda M; Smith, Albert Vernon; Schurmann, Claudia; Vacchi-Suzzi, Caterina; Waterworth, Dawn M ... Auer, Paul L (2016). Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. American Journal of Human Genetics, 99 (1), 22−39.10.1016/j.ajhg.2016.05.003.
1.1.
2016
Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement; Fontanillas, Pierre; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M ... McCarthy, Mark I (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41−47.10.1038/nature18642.
1.1.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8), 856−866.10.1038/ng.3598.
1.1.
2016
Chami, Nathalie; Chen, Ming-Huei; Slater, Andrew J; Eicher, John D; Evangelou, Evangelos; Tajuddin, Salman M; Love-Gregory, Latisha; Kacprowski, Tim; Schick, Ursula M; Nomura, Akihiro; Giri, Ayush; Lessard, Samuel; Brody, Jennifer A; Schurmann, Claudia; Pankratz, Nathan; Yanek, Lisa R; Manichaikul, Ani; Pazoki, Raha; Mihailov, Evelin; Hill, W David ... Lettre, Guillaume (2016). Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. American Journal of Human Genetics, 99 (1), 8−21.10.1016/j.ajhg.2016.05.007.
1.1.
2016
Tšuiko, O.; Nõukas, M.; Žilina, O.; Hensen, K.; Tapanainen, J.; Mägi, R.; Kals, M.; Kivistik, PA.; Haller-Kikkatalo, K.; Salumets, A.; Kurg, A. (2016). Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases. Human Reproduction, 31 (8), 1913−1925.10.1093/humrep/dew142.
1.1.
2016
Laisk-Podar, Triin; Lindgren, Cecilia M; Peters, Maire; Tapanainen, Juha S; Lambalk, Cornelis B; Salumets, Andres; Mägi, Reedik (2016). Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond. Trends in endocrinology and metabolism: TEM, 27 (7), 516−528.10.1016/j.tem.2016.04.011.
1.1.
2016
Läll, Kristi; Mägi, Reedik; Morris, Andrew; Metspalu, Andres; Fischer, Krista (2016). Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores. Genetics in medicine, 1−10.10.1038/gim.2016.103.
1.1.
2016
Pagani, Luca; Lawson, Daniel John; Jagoda, Evelyn; Mörseburg, Alexander; Eriksson, Anders; Mitt, Mario; Clemente, Florian; Hudjashov, Georgi; DeGiorgio, Michael; Saag, Lauri; Wall, Jeffrey D; Cardona, Alexia; Mägi, Reedik; Sayres, Melissa A Wilson; Kaewert, Sarah; Inchley, Charlotte; Scheib, Christiana L; Järve, Mari; Karmin, Monika; Jacobs, Guy S ... Metspalu, Mait. (2016). Genomic analyses inform on migration events during the peopling of Eurasia. Nature, 538 (7624), 238−242.10.1038/nature19792.
1.1.
2016
Pattaro, Cristian; Teumer, Alexander; Gorski, Mathias; Chu, Audrey Y; Li, Man; Mijatovic, Vladan; Garnaas, Maija; Tin, Adrienne; Sorice, Rossella; Li, Yong; Taliun, Daniel; Olden, Matthias; Foster, Meredith; Yang, Qiong; Chen, Ming-Huei; Pers, Tune H; Johnson, Andrew D; Ko, Yi-An; Fuchsberger, Christian; Tayo, Bamidele ... Fox, Caroline S (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications, 7 (10023), 10023−10023.10.1038/ncomms10023.
1.1.
2016
Inchley, Charlotte E; Larbey, Cynthia D A; Shwan, Nzar A A; Pagani, Luca; Saag, Lauri; Antão, Tiago; Jacobs, Guy; Hudjashov, Georgi; Metspalu, Ene; Mitt, Mario; Eichstaedt, Christina A; Malyarchuk, Boris; Derenko, Miroslava; Wee, Joseph; Abdullah, Syafiq; Ricaut, François-Xavier; Mormina, Maru; Mägi, Reedik; Villems, Richard; Metspalu, Mait ... Kivisild, Toomas (2016). Selective sweep on human amylase genes postdates the split with Neanderthals. Scientific Reports, 6, 37198−37198.10.1038/srep37198.
1.1.
2016
Ganna A, Genovese G, Howrigan DP, Byrnes A, Kurki MI, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman CM, Neale BM. (2016). Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nature Neuroscience, 19 (12), 1563−1565.10.1038/nn.4404.
1.1.
2016
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stančáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D'Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N, Graff M, Grallert H, Grarup N, Gräßler J, Grewal J, Hamsten A, Harder MN, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Havulinna AS, Heliövaara M, Hillege H, Hofman A, Holmen O, Homuth G, Hottenga JJ, Hui J, Husemoen LL, Hysi PG, Isaacs A, Ittermann T, Jalilzadeh S, James AL, Jørgensen T, Jousilahti P, Jula A, Marie Justesen J, Justice AE, Kähönen M, Karaleftheri M, Tee Khaw K, Keinanen-Kiukaanniemi SM, Kinnunen L, Knekt PB, Koistinen HA, Kolcic I, Kooner IK, Koskinen S, Kovacs P, Kyriakou T, Laitinen T, Langenberg C, Lewin AM, Lichtner P, Lindgren CM, Lindström J, Linneberg A, Lorbeer R, Lorentzon M, Luben R, Lyssenko V, Männistö S, Manunta P, Leach IM, McArdle WL, Mcknight B, Mohlke KL, Mihailov E, Milani L, Mills R, Montasser ME, Morris AP, Müller G, Musk AW, Narisu N, Ong KK, Oostra BA, Osmond C, Palotie A, Pankow JS, Paternoster L, Penninx BW, Pichler I, Pilia MG, Polašek O, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rayner NW, Ribel-Madsen R, Rice TK, Richards M, Ridker PM, Rivadeneira F, Ryan KA, Sanna S, Sarzynski MA, Scholtens S, Scott RA, Sebert S, Southam L, Sparsø TH, Steinthorsdottir V, Stirrups K, Stolk RP, Strauch K, Stringham HM, Swertz MA, Swift AJ, Tönjes A, Tsafantakis E, van der Most PJ, Van Vliet-Ostaptchouk JV, Vandenput L, Vartiainen E, Venturini C, Verweij N, Viikari JS, Vitart V, Vohl MC, Vonk JM, Waeber G, Widén E, Willemsen G, Wilsgaard T, Winkler TW, Wright AF, Yerges-Armstrong LM, Hua Zhao J, Carola Zillikens M, Boomsma DI, Bouchard C, Chambers JC, Chasman DI, Cusi D, Gansevoort RT, Gieger C, Hansen T, Hicks AA, Hu F, Hveem K, Jarvelin MR, Kajantie E, Kooner JS, Kuh D, Kuusisto J, Laakso M, Lakka TA, Lehtimäki T, Metspalu A, Njølstad I, Ohlsson C, Oldehinkel AJ, Palmer LJ, Pedersen O, Perola M, Peters A, Psaty BM, Puolijoki H, Rauramaa R, Rudan I, Salomaa V, Schwarz PE, Shudiner AR, Smit JH, Sørensen TI, Spector TD, Stefansson K, Stumvoll M, Tremblay A, Tuomilehto J, Uitterlinden AG, Uusitupa M, Völker U, Vollenweider P, Wareham NJ, Watkins H, Wilson JF, Zeggini E, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, van Duijn CM, Fox C, Groop LC, Heid IM, Hunter DJ, Kaplan RC, McCarthy MI, North KE, O'Connell JR, Schlessinger D, Thorsteinsdottir U, Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJ. (2016). A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications, e13357, 1−11.10.1038/ncomms13357.
1.1.
2016
Walford, Geoffrey A.; Gustafsson, Stefan; Rybin, Denis; Stancakova, Alena; Chen, Han; Liu, Ching-Ti; Hong, Jaeyoung; Jensen, Richard A.; Rice, Ken; Morris, Andrew P.; Magi, Reedik; Toenjes, Anke; Prokopenko, Inga; Kleber, Marcus E.; Delgado, Graciela; Silbernagel, Guenther; Jackson, Anne U.; Appel, Emil V.; Grarup, Niels; Lewis, Joshua P. ... Florez, Jose C. (2016). Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes, 10, 3200−3211.10.2337/db16-0199.
1.1.
2016
Eicher, John D; Chami, Nathalie; Kacprowski, Tim; Nomura, Akihiro; Chen, Ming-Huei; Yanek, Lisa R; Tajuddin, Salman M; Schick, Ursula M; Slater, Andrew J; Pankratz, Nathan; Polfus, Linda; Schurmann, Claudia; Giri, Ayush; Brody, Jennifer A; Lange, Leslie A; Manichaikul, Ani; Hill, W David; Pazoki, Raha; Elliot, Paul; Evangelou, Evangelos ... Johnson, Andrew D (2016). Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. American Journal of Human Genetics, 99 (1), 40−55.10.1016/j.ajhg.2016.05.005.
1.1.
2016
Pagani, Luca; Lawson, Daniel John; Jagoda, Evelyn; Mörseburg, Alexander; Eriksson, Anders; Mitt, Mario; Clemente, Florian; Hudjashov, Georgi; DeGiorgio, Michael; Saag, Lauri; Wall, Jeffrey D; Cardona, Alexia; Mägi, Reedik; Sayres, Melissa A Wilson; Kaewert, Sarah; Inchley, Charlotte; Scheib, Christiana L; Järve, Mari; Karmin, Monika; Jacobs, Guy S ... Metspalu, Mait (2016). Genomic analyses inform on migration events during the peopling of Eurasia. Nature, 1−5.10.1038/nature19792.
6.8.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno. (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (10), 1296−1296.10.1038/ng1016-1296c.
1.1.
2015
Zimmermann, E; Angquist, LH; Mirza, S S; Zhao, J H; Chasman, D I; Fischer, K; Qi, Q; Smith, A V; Thinggaard, M; Jarczok, M N; Nalls, M A; Trompet, S; Timpson, N J; Schmidt, B; Jackson, A U; Lyytikainen, L P; Verweij, N; Mueller-Nurasyid, M; Vikstrom, M; Marques-Vidal, P ... Sorensen, TIA. (2015). Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obesity Reviews, 16 (4), 327−340.10.1111/obr.12263.
1.1.
2015
Fall, T; Xie, W; Poon, W; Yaghootkar, H; Mägi, R; GENESIS, Consortium; Knowles, JW; Lyssenko, V; Weedon, M; Frayling, TM; Ingelsson, E. (2015). Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes. Diabetes, 64 (7), 2676−2684.10.2337/db14-1710.
1.1.
2015
Horikoshi, M; Mӓgi, R; van, de, Bunt, M; Surakka, I; Sarin, AP; Mahajan, A; Marullo, L; Thorleifsson, G; Hӓgg, S; Hottenga, JJ; Ladenvall, C; Ried, JS; Winkler, TW; Willems, SM; Pervjakova, N; Esko, T; Beekman, M; Nelson, CP; Willenborg, C; Wiltshire, S ... ENGAGE, Consortium. (2015). Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. Plos Genetics, 11 (7), e1005230.10.1371/journal.pgen.1005230.
1.1.
2015
Surakka, I; Horikoshi, M; Mägi, R; Sarin, AP; Mahajan, A; Lagou, V; Marullo, L; Ferreira, T; Miraglio, B; Timonen, S; Kettunen, J; Pirinen, M; Karjalainen, J; Thorleifsson, G; Hägg, S; Hottenga, JJ; Isaacs, A; Ladenvall, C; Beekman, M; Esko, T ... ENGAGE, Consortium. (2015). The impact of low-frequency and rare variants on lipid levels. Nature Genetics, 47 (6), 589−597.10.1038/ng.3300.
1.1.
2015
Fall, T; Hägg, S; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Sarin, AP; Benyamin, B; Ladenvall, C; Åkerlund, M; Kals, M; Esko, T; Nelson, CP; Kaakinen, M; Huikari, V; Mangino, M; Meirhaeghe, A; Kristiansson, K; Nuotio, ML; Kobl, M ... ENGAGE, Consortium. (2015). Age- and sex-specific causal effects of adiposity on cardiovascular risk factors. Diabetes, 64 (5), 1841−1852.10.2337/db14-0988.
1.1.
2015
Pers, TH.; Karjalainen, JM.; Chan, Y.; Westra, HJ.; Wood, AR.; Yang, J.; , Lui, JC.; Vedantam, S.; Gustafsson, S.; Esko, T.; Frayling, T.; Speliotes, EK.; Genetic, Investigation, of, ANthropometric, Traits, (GIANT), Consortium; Boehnke, M.; Raychaudhuri, S.; Fehrmann, RS.; Hirschhorn, JN.; Franke, L. (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications, 6 (5890), 1−9.10.1038/ncomms6890.
1.1.
2015
Zhu, Z; Bakshi, A; Vinkhuyzen, AA; Hemani, G; Lee, SH; Nolte, IM; van, Vliet-Ostaptchouk, JV; Snieder, H; The, LifeLines, Cohort, Study; Esko, T; Milani, L; Mägi, R; Metspalu, A; Hill, WG; Weir, BS; Goddard, ME; Visscher, PM; Yang, J. (2015). Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits. American Journal of Human Genetics, 96 (3), 377−85.10.1016/j.ajhg.2015.01.001.
1.1.
2015
Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Locke, AE; Mägi, R; Strawbridge, RJ; Pers, TH; Fischer, K; Justice, AE; Workalemahu, T; Wu, JM; Buchkovich, ML; Heard-Costa, NL; Roman, TS; Drong, AW; Song, C; Gustafsson, S; Day, FR; Esko, T ... Mohlke, KL. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187−196.10.1038/nature14132.
1.1.
2015
Locke, AE.; Kahali, B.; Berndt, SI.; Justice, AE.; Pers, TH.; Day, FR.; Powell, C.; Vedantam, S.; Buchkovich, ML.; Yang, J.; Croteau-Chonka, DC.; Esko, T.; Fall, T.; Ferreira, T.; Gustafsson, S.; Kutalik, Z.; Luan, J.; Mägi, R.; Randall, JC.; Winkler, TW. ... Speliotes, EK. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197−206.10.1038/nature14177.
1.1.
2015
The, Coffee, and, Caffeine, Genetics, Consortium; Cornelis, MC; Byrne, EM; Esko, T; Nalls, MA; Ganna, A; Paynter, N; Monda, KL; Amin, N; Fischer, K; Renstrom, F; Ngwa, JS; Huikari, V; Cavadino, A; Nolte, IM; Teumer, A; Yu, K; Marques-Vidal, P; Rawal, R; Manichaikul, A ... Chasman, DI. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647−656.10.1038/mp.2014.107.
1.1.
2015
Hägg, S; Ganna, A; Van, Der, Laan, SW; Esko, T; Pers, TH; Locke, AE; Berndt, SI; Justice, AE; Kahali, B; Siemelink, MA; Pasterkamp, G; GIANT, Consortium; Strachan, DP; Speliotes, EK; North, KE; Loos, RJ; Hirschhorn, JN; Pawitan, Y; Ingelsson, E. (2015). Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity. Human Molecular Genetics, 24 (23), 6849−6860.10.1093/hmg/ddv379.
1.1.
2015
Lunetta, KL; Day, FR; Sulem, P; Ruth, KS; Tung, JY; Hinds, DA; Esko, T; Elks, CE; Altmaier, E; He, C; Huffman, JE; Mihailov, E; Porcu, E; Robino, A; Rose, LM; Schick, UM; Stolk, L; Teumer, A; Thompson, DJ; Traglia, M ... Perry, JR. (2015). Rare coding variants and X-linked loci associated with age at menarche. Nature Communications, 6 (7756), 1−7.10.1038/ncomms8756.
1.1.
2015
Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F.; Chu, Su; Czajkowski, Jacek; Esko, Tonu; Fall, Tove; Kilpelainen, Tuomas O.; Lu, Yingchang; Magi, Reedik; Mihailov, Evelin; Pers, Tune H.; Rueeger, Sina; Teumer, Alexander; Ehret, Georg B.; Ferreira, Teresa; Heard-Costa, Nancy L.; Karjalainen, Juha ... Loos, Ruth J. F. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Plos Genetics, 11 (10), ARTN e1005378.10.1371/journal.pgen.1005378.
1.1.
2015
Wain, LV; Shrine, N; Miller, S; Jackson, VE; Ntalla, I; Artigas, MS; Billington, CK; Kheirallah, AK; Allen, R; Cook, JP; Probert, K; Obeidat, M; Bosse, Y; Hao, K; Postma, DS; Pare, PD; Ramasamy, A; Magi, R; Mihailov, E; Reinmaa, E Melen, E ... Hall, IP (2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. The Lancet Respiratory Medicine, 3 (10), 769−781.10.1016/S2213-2600(15)00283-0.
1.1.
2015
Joshi, PK; Esko, T; Mattsson, H; Eklund, N; Gandin, I; Nutile, T; Jackson, AU; Schurmann, C; Smith, AV; Zhang, W; Okada, Y; Stančáková, A; Faul, JD; Zhao, W; Bartz, TM; Concas, MP; Franceschini, N; Enroth, S; Vitart, V; Trompet, S ... Wilson, JF. (2015). Evidence for directional dominance on complex traits relating to size and cognition in a wide range of human populations. Nature, 46 (11), 1173−1186.10.1038/nature14618.
1.1.
2015
Huffman, JE; Albrecht, E; Teumer, A; Mangino, M; Kapur, K; Johnson, T; Kutalik, Z; Pirastu, N; Pistis, G; Lopez, LM; Haller, T; Salo, P; Goel, A; Li, M; Tanaka, T; Dehghan, A; Ruggiero, D; Malerba, G; Smith, AV; Nolte, IM ... Vitart, V. (2015). Modulation of genetic associations with serum urate levels by body-mass-index in humans. PLoS ONE, 3, e0119752−e0119752.10.1371/journal.pone.0119752.
1.1.
2015
Gaulton, Kyle J; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E; Mahajan, Anubha; Locke, Adam; Rayner, N William; Robertson, Neil; Scott, Robert A; Prokopenko, Inga; Scott, Laura J; Green, Todd; Sparso, Thomas; Thuillier, Dorothee; Yengo, Loic; Grallert, Harald; Wahl, Simone; Frånberg, Mattias ... , (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47 (12), 1415−1425.10.1038/ng.3437.
1.1.
2015
Haller, Toomas; Kals, Mart; Esko, Tõnu; Mägi, Reedik; Fischer, Krista (2015). RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations. Briefings in bioinformatics, 16 (1), 39−44.10.1093/bib/bbt066.
1.1.
2015
Leitsalu, Liis; Haller, Toomas; Esko, Tõnu; Tammesoo, Mari-Liis; Alavere, Helene; Snieder, Harold; Perola, Markus; Ng, Pauline C; Mägi, Reedik; Milani, Lili; Fischer, Krista; Metspalu, Andres (2015). Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu. International Journal of Epidemiology, 44 (4), 1137−1147.10.1093/ije/dyt268.
1.1.
2015
Hägg, S; Fall, T; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Kals, M; de Vries, PS; Dehghan, A; Willems, SM; Sarin, AP; Kristiansson, K; Nuotio, ML; Havulinna, AS; de Bruijn, RF; Ikram, MA; Kuningas, M; Stricker, BH; Franco, OH; Benyamin, B ... European, Network, for, Genetic, and, Genomic, Epidemiology, (ENGAGE) consortium. (2015). Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. International Journal of Epidemiology, 44 (2), 578−586.10.1093/ije/dyv094.
1.1.
2015
Day, Felix R; Ruth, Katherine S; Thompson, Deborah J; Lunetta, Kathryn L; Pervjakova, Natalia; Chasman, Daniel I; Stolk, Lisette; Finucane, Hilary K; Sulem, Patrick; Bulik-Sullivan, Brendan; Esko, Tõnu; Johnson, Andrew D; Elks, Cathy E; Franceschini, Nora; He, Chunyan; Altmaier, Elisabeth; Brody, Jennifer A; Franke, Lude L; Huffman, Jennifer E; Keller, Margaux F ... Murray, Anna (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47 (11), 1294−303.10.1038/ng.3412.
1.1.
2015
Männik, Katrin; Mägi, Reedik; Macé, Aurélien; Cole, Ben; Guyatt, Anna L; Shihab, Hashem A; Maillard, Anne M; Alavere, Helene; Kolk, Anneli; Reigo, Anu; Mihailov, Evelin; Leitsalu, Liis; Ferreira, Anne-Maud; Nõukas, Margit; Teumer, Alexander; Salvi, Erika; Cusi, Daniele; McGue, Matt; Iacono, William G; Gaunt, Tom R ... Reymond, Alexandre (2015). Copy Number Variations and Cognitive Phenotypes in Unselected Populations. JAMA : the journal of the American Medical Association, 313 (20), 2044−2054.10.1001/jama.2015.4845.
1.1.
2015
Karmin, Monika; Saag, Lauri; Vicente, Mário; Wilson Sayres, Melissa A; Järve, Mari; Talas, Ulvi Gerst; Rootsi, Siiri; Ilumäe, Anne-Mai; Mägi, Reedik; Mitt, Mario; Pagani, Luca; Puurand, Tarmo; Faltyskova, Zuzana; Clemente, Florian; Cardona, Alexia; Metspalu, Ene; Sahakyan, Hovhannes; Yunusbayev, Bayazit; Hudjashov, Georgi; DeGiorgio, Michael ... Kivisild, Toomas (2015). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Genome Research, 25 (4), 459−466.10.1101/gr.186684.114.
5.1.
2015
Kaakinen, M.; Maegi, R.; Fischer, K.; Jarvelin, M. -R.; Morris, A. P.; Prokopenko, I. (2015). A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants. Human Heredity, 79: 43rd European Mathematical Genetics Meeting (EMGM), Brest, FRANCE, APR 16-17, 2015. Karger, 39−39. (1).
1.1.
2014
Walsh, KM; Codd, V; Smirnov, IV; Rice, T; Decker, PA; Hansen, HM; Kollmeyer, T; Kosel, ML; Molinaro, AM; McCoy, LS; Bracci, PM; Cabriga, BS; Pekmezci, M; Zheng, S; Wiemels, JL; Pico, AR; Tihan, T; Berger, MS; Chang, SM; Prados, MD ... Wrensch, MR. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46 (7), 731−735.10.1038/ng.3004.
1.1.
2014
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y14; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J ... Frayling, TM. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173−1186.10.1038/ng.3097.
1.1.
2014
Clemente, FJ.; Cardona, A.; Inchley, CE.; Peter, BM.; Jacobs, G.; Pagani, L.; Lawson, DJ.; Antao, T.; Vicente, M.; Mitt, M.; DeGiorgio, M.; Faltyskova, Z.; Xue, YL.; Ayub, Q.; Szpak, M.; Magi, R.; Eriksson, A.; Manica, A.; Raghavan, M.; Rasmussen, M. ... Kivisild, T. (2014). A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. American Journal of Human Genetics, 95 (5), 584−589.10.1016/j.ajhg.2014.09.016.
1.1.
2014
Dimas, AS; Lagou, V; Barker, A; Knowles, JW; Magi, R; Hivert, MF; Benazzo, A; Rybin, D; Jackson, AU; Stringham, HM; Song, C; Fischer-Rosinsky, A; Boesgaard, TW; Grarup, N; Abbasi, FA; Assimes, TL; Hao, K; Yang, X Lecoeur, C; Barroso, I; Bonnycastle, LL ... MAGIC, Investigators. (2014). Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity. Diabetes, 63 (6), 2158−2171.10.2337/db13-0949.
1.1.
2014
Perry, J.R.B.; Day, F.; Elks, C.E.; Sulem, P.; Thompson, D.J.; Ferreira, T.; He, C.; Chasman, D.I.; Esko, T.; Thorleifsson, G.; Albrecht, E.; Ang, W.Q.; Corre, T.; Cousminer, D.L.; Feenstra, B.; Franceschini, N.; Ganna, A.; Johnson, A.D.; Kjellqvist, S.; Lunetta, K.L. ... Ong, K.K. (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92.10.1038/nature13545.
1.1.
2014
Hoggart, CJ; Venturini, G; Mangino, M; Gomez, F; Ascari, G; Zhao, JH; Teumer, A; Winkler, TW; Tsernikova, N; Luan, J; Mihailov, E; Ehret, GB; Zhang, W; Lamparter, D; Esko, T; Mace, A; Rueger, S; Bochud, P-Y; Barcella, M; Dauvilliers, Y ... Kutalik, Z. (2014). Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. Plos Genetics, 10 (7), e1004508.10.1371/journal.pgen.1004508.
1.1.
2014
Metsalu, Tauno; Viltrop, Triin; Tiirats, Airi; Rajashekar, Balaji; Reimann, Ene; Kõks, Sulev; Rull, Kristiina; Milani, Lili; Acharya, Ganesh; Basnet, Purusotam; Vilo, Jaak; Mägi, Reedik; Metspalu, Andres; Peters, Maire; Haller-Kikkatalo, Kadri; Salumets, Andres (2014). Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. Epigenetics, 9 (10), 1397−1409.10.4161/15592294.2014.970052.
1.1.
2014
Lim, ET.; Würtz, Peter; Havulinna, AS.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, RM.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina ... SISu, Project (2014). Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. PLOS Genetics, 10 (7), e1004494.10.1371/journal.pgen.1004494.
1.1.
2014
Mägi, Reedik; Metspalu, Andres; Mihailov, Evelin (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234−244.10.1038/ng.2897.
1.1.
2014
Schramm, Katharina; Marzi, Carola; Schurmann, Claudia; Carstensen, Maren; Reinmaa, Eva; Biffar, Reiner; Eckstein, Gertrud; Gieger, Christian; Grabe, Hans-Jorgen; Homuth, Georg; Kastenmuller, Gabriele; Magi, Reedik; Metspalu, Andres; Mihailov, Evelin; Peters, Annette; Petersmann, Astrid; Roden, Michael; Strauch, Konstantin; Suhre, Karsten; Teumer, Alexander ... Prokisch, Holger (2014). Mapping the genetic architecture of gene regulation in whole blood. PLoS ONE, 9 (4), e93844−e93844.10.1371/journal.pone.0093844.
1.1.
2014
Winkler, T.W.; Day, FR.; Croteau-Chonka, DC.; Wood, AR.; Locke, AE.; Magi, R.; Ferreira, T.; Fall, T.; Graff, M.; Justice, AE.; Luan, JA.; Gustafsson, S.; Randall, JC.; Vedantam, S.; Workalemahu, T.; Kilpelainen, TO.; Scherag, A.; Esko, T.; Kutalik, Z.; Heid, IM. ... Loos, RJF (2014). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5), 1192−1212.10.1038/nprot.2014.071.
1.1.
2014
Prokopenko, Inga; Poon, Wenny; Magi, Reedik; Prasad B, Rashmi; Salehi, S Albert; Almgren, Peter; Osmark, Peter; Bouatia-Naji, Nabila; Wierup, Nils; Fall, Tove; Stancakova, Alena; Barker, Adam; Lagou, Vasiliki; Osmond, Clive; Xie, Weijia; Lahti, Jari; Jackson, Anne U; Cheng, Yu-Ching; Liu, Jie; O'Connell, Jeffrey R ... Lyssenko, Valeriya (2014). A central role for GRB10 in regulation of islet function in man. Plos Genetics, 10 (4), e1004235−e1004235.10.1371/journal.pgen.1004235.
1.1.
2014
Lokk, Kaie; Modhukur, Vijayachitra; Rajashekar, Balaji; Märtens, Kaspar; Mägi, Reedik; Kolde, Raivo; Koltšina, Marina; Nilsson, Torbjörn K.; Vilo, Jaak; Salumets, Andres; Tõnisson, Neeme (2014). DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biology, 15 (4), R54.10.1186/gb-2014-15-4-r54.
1.1.
2014
Fischer, K.; Kettunen, J.; Würtz, P.; Haller, T.; Aki S. Havulinna, A.S.; Kangas, A.J.; Soininen, P.; Esko, T.; Tammesoo, M-L.; Mägi, R.; Smit, S.; Palotie, A.; SRipatti, S.; Veikko Salmaa, V.; Ala-Korpela, M.; Perola, M.; Metspalu, A. (2014). Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons. PLOS Medicine, 11 (2), e1001606.10.1371/journal.pmed.1001606.
1.1.
2014
Raghavan, M.; Skoglund, P.; Graf, K.E.; Metspalu, M.; Albrechtsen, A.; Moltke, I.; Rasmussen, S.; Stafford, T.W. Jr.; Orlando, L.; Metspalu, E.; Karmin, M.; Tambets, K.; Rootsi, S.; Mägi, R.; Campos, P.F., Balanovska, E., Balanovsky, O., Khusnutdinova, E., Litvinov, S.; Osipova, L.P.; Fedorova, S.A.; Voevoda, M.I.; DeGiorgio, M.; Sicheritz-Ponten, T. ... Willerslev, E. (2014). Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature, 505 (7481), 87−91.10.1038/nature12736.
5.1.
2014
Morris, A. P.; Teslovich, T. M.; Ferreira, T.; Mahajan, A.; Lee, Y.; Rayner, N. W.); Magi, R. (2014). Fine-mapping type 2 diabetes susceptibility loci with high-density imputation. DIABETOLOGIA, 57: 50th EASD Annual Meeting, Vienna, Austria, 15-19.09.2014. Springer, S50−S51.
1.1.
2013
Mägi, R.; Manning, S.; Yousseif, A.; Pucci, A.; Santini, F.; Karra, E.; Querci, G.; Pelosini, C.; McCarthy, M.I.; Lindgren, C.M.; Batterham, R.L. (2013). Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery. PLoS ONE, 8 (8), e70735.10.1371/journal.pone.0070735.
1.1.
2013
Evans, DM; Brion, MJ; Paternoster, L; Kemp, JP; McMahon, G; Munafò, M; Whitfield, JB; Medland, SE; Montgomery, GW; GIANT, Consortium; CRP, Consortium; TAG, Consortium; Timpson, NJ; St Pourcain, B; Lawlor, DA; Martin, NG; Dehghan, A; Hirschhorn, J; Davey, Smith, G. (2013). Mining the human phenome using allelic scores that index biological intermediates. Plos Genetics, 9 (10), e1003919−e1003919.10.1371/journal.pgen.1003919.
1.1.
2013
Vimaleswaran, KS.; Berry, DJ.; Lu, C.; Tikkanen, E.; Pilz, S.; Hiraki, LT.; Cooper, JD.; Dastani, Z.; Li, R.; Houston, DK.; Wood, AR.; Michaëlsson, K.; Vandenput, L.; Zgaga, L.; Yerges-Armstrong, LM.; McCarthy, MI.; Dupuis, J.; Kaakinen, M.; Kleber, ME.; Jameson, K. ... Hyppönen, E. (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLOS Medicine, 10 (2), e1001383.10.1371/journal.pmed.1001383.
1.1.
2013
Paul, Dirk S.; Albers, Cornelis A.; Rendon, Augusto; Voss, Katrin; Stephens, Jonathan; HaemGen, Consortium; van der Harst, Pim; Chambers, John C.; Soranzo, Nicole; Ouwehand, Willem H.; Deloukas, Panos (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Research, 23 (7), 1130−1141.10.1101/gr.155127.113.
1.1.
2013
Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpeläinen, TO; Esko, T; Mägi, R; Li, S; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A ... Heid, IM (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. Plos Genetics, 9 (6), e1003500.10.1371/journal.pgen.1003500.
1.1.
2013
Thorgeirsson, TE; Gudbjartsson, DF; Sulem, P; Besenbacher, S; Styrkarsdottir, U; Thorleifsson, G; Walters, GB; TAG, Consortium; Oxford-GSK, Consortium; ENGAGE, consortium; Furberg, H; Sullivan, PF; Marchini, J; McCarthy, MI; Steinthorsdottir, V; Thorsteinsdottir, U; Stefansson, K. (2013). A common biological basis of obesity and nicotine addiction. Translational Psychiatry, 3, 1−7.10.1038/tp.2013.81.
1.1.
2013
Tammiste, Anu; Jiang, Tao; Fischer, Krista; Mägi, Reedik; Krjutškov, Kaarel; Pettai, Kristi; Esko, Tõnu; Li, Yingrui; Tansey, Katherine E; Carroll, Liam S; Uher, Rudolf; McGuffin, Peter; Võsa, Urmo; Tšernikova, Natalia; Saria, Alois; Ng, Pauline C; Eller, Triin; Vasar, Veiko; Nutt, David J; Maron, Eduard ... Metspalu, Andres (2013). Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression. Journal of Psychopharmacology, 27 (10), 915−920.10.1177/0269881113499829.
1.1.
2013
Fall, T.; Hagg, S.; Magi, R.; Ploner, A.; Fischer, K.; Horikoshi, M.; Sarin, AP.; Thorleifsson, G.; Ladenvall, C.; Kals, M.; Kuningas, M.; Draisma, HHM.; Ried, JS.; van Zuydam, NR.; Huikari, V.; Mangino, M.; Sonestedt, E.; Benyamin, B.; Nelson, CP.; Rivera, NV. ... Prokopenko, I. (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLOS Medicine, 10 (6), e1001474−e1001474.10.1371/journal.pmed.1001474.
1.1.
2013
Migliano, A.; Romero, I.; Metspalu, M.; Leavesley, M.; Pagani, L.; Antao, T.; Huang, D.; Sherman, B.; Siddle, K.; Scoles, C.; Hudjashov, G.; Kaitokai, E.; Mandui, H.; Babalu, A.; Belatti, M.; Cagan, A.; Hopkinshow, B.; Show, C.; Tabbada, K.; Nelis, M. ... Kivisild, T. (2013). Evolution of the pygmy phenotype: evidence of positive selection from genome-wide scans in African, Asian and Melanesian pygmies. Human Biology, 85, 251−284.
1.1.
2013
Nikopensius, T; Annilo, T; Jagomägi, T; Gilissen, C; Kals, M; Krjutškov, K; Mägi, R; Eelmets, M; Gerst-Talas, U; Remm, M; Saag, M; Hoischen, A; Metspalu, A (2013). Non-syndromic Tooth Agenesis Associated with a Nonsense Mutation in Ectodysplasin-A (EDA). Journal of Dental Research, 92 (6), 507−511.10.1177/0022034513487210.
1.1.
2013
Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69.10.1038/ng.2606.
1.1.
2013
Codd, V; Nelson, CP; Albrecht, E; Mangino, M; Deelen, J; Buxton, JL; Hottenga, JJ; Fischer, K; Esko, T; Surakka, I; Broer, L; Nyholt, DR; Leach, IM; Salo, P; Hägg, S; Matthews, MK; Palmen, J; Norata, GD; O'Reilly, PF; Saleheen, D ... Samani, NJ (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45 (4), 422−427.10.1038/ng.2528.
1.1.
2013
Hu, YJ; Berndt, SI; Gustafsson, S; Ganna, A; Genetic Investigation of ANthropometric Traits (GIANT), Consortium; Hirschhorn, J; North, KE; Ingelsson, E; Lin, DY (2013). Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. American Journal of Human Genetics, 93 (2), 236−248.10.1016/j.ajhg.2013.06.011.
1.1.
2013
Parsa, A; Fuchsberger, C; Köttgen, A; O'Seaghdha, CM; Pattaro, C; de Andrade, M; Chasman, DI; Teumer, A; Endlich, K; Olden, M; Chen, MH; Tin, A; Kim, YJ; Taliun, D; Li, M; Feitosa, M; Gorski, M; Yang, Q; Hundertmark, C; Foster, MC ... Böger, CA. (2013). Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function. Journal of the American Society of Nephrology, 24 (12), 2105−2117.10.1681/ASN.2012100983.
5.1.
2013
Lagou, V.; Mägi, R.; Surakka, I. ; Sarin, A. -P.; Horikoshi, M.; Thorleifsson, G. ; Hagg, S.; Beekman, M.; Ladenvall, C.; Hottenga, J. -J.; Ried, J. S.; McCarthy, M. I.Morris, A.; Ripatti, S.; Prokopenko, I. (2013). Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S60.
5.1.
2013
Horikoshi, M.; Mägi, R.; Surakka, I.; Sarin, A. -P.; Mahajan, A.; Marullo, L.; Ferreira, T. ; Esko, T.; Lindgren, C. M.; Morris, A. P.; McCarthy, M. I.; Ripatti, S.; Prokopenko, I; ENGAGE, Consortium. (2013). Large-scale genome-wide association meta-analysis of the 1000 genomes project imputed data identifies novel susceptibility loci for glycaemic and obesity traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S61.
5.1.
2013
Horikoshi, Momoko; Magi, Reedik; Surakka, Ida; Sarin, Antti-Pekka; Mahajan, Anubha; Marullo, Letizia; Ferreira, Teresa; Esko, Tonu; Morris, Andrew P.; Mccarthy, Mark I.; Ripatti, Samuli; Prokopenko, Inga (2013). Large-Scale Genome-Wide Association Meta-Analysis using Imputation from the Dense 1000 Genomes Project Map Identifies Novel Susceptibility Loci for Glycemic and Obesity Traits. Diabetes, A83−A83.
5.2.
2013
Žilina, Olga; Mägi, Reedik; Kurg, Ants; Õunap, Katrin (2013). https://www.eshg.org/fileadmin/www.eshg.org/conferences/2013/ESHG2013AbstractsWebsite.pdf. European Journal of Human Genetics, 21: European Human Genetics Conference 2013, Paris France, June 8-11, 2013. Ed. G-J B van Ommen. Nature Publishing Group, 183−183. (2).
5.2.
2013
Tõnisson, N.; Lokk, K; Modhukur, V.; Rajashekar, B; Martens, K; Koltšina, M; Mägi, R.; Kolde, R.; Salumets, A. (2013). DNA metylome comparison of various human tissues. European Journal of Human Genetics: European Human Genetics Conference; Pariis, Prantsusmaa; 8.–11. juuni, 2013. Nature Publishing Group, 373−373. (21; Suppl 2).
1.1.
2012
Chasman, DI.; Fuchsberger, C.; Pattaro, C.; Teumer, A.; Boger, CA.; Endlich, K.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Kottgen, A. (2012). Integration of Genome-Wide Association Studies with Biological Knowledge Identifies Six Novel Genes Related to Kidney Function. Human Molecular Genetics, 21 (24), 5329−5343.10.1093/hmg/dds369.
1.1.
2012
Nürnberg, ST.; Rendon, A.; Smethurst, PA.; Paul, DS.; Voss, K.; Thon, JN.; Lloyd-Jones, H.; Sambrook, JG.; Tijssen, MR.; Gieger, C.; Radhakrishnan, A.; Cvejic, A.; Tang, W.; Porcu, E.; Pistis, G.; Serbanovic-Canic, J.; Elling, U.; Goodall, AH.; Labrune, Y.; Lopez, LM. ... Ouwehand, W. (2012). A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood, 120 (24), 4859−4868.10.1182/blood-2012-01-401893.
1.1.
2012
Mägi, R; Asimit, JL; Day-Williams, AG; Zeggini, E; Morris, AP. (2012). Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases. Genetic Epidemiology, 36 (8), 785−796.10.1002/gepi.21675.
1.1.
2012
Okada, Y; Sim, X; Go, MJ; Wu, JY; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, SC; Wong, TY; Liu, J; Young, TL; Aung, T; Seielstad, M; Teo, YY; Kim, YJ; Lee, JY; Han, BG ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904−909.10.1038/ng.2352.
1.1.
2012
Yang, J; Loos, RJ; Powell, JE; Medland, SE; Speliotes, EK; Chasman, DI; Rose, LM; Thorleifsson, G; Steinthorsdottir, V; Mägi, R; Waite, L; Vernon, Smith, A; Yerges-Armstrong, LM; Monda, KL; Hadley, D; Mahajan, A; Li, G; Kapur, K; Vitart, V; Huffman, JE ... Visscher, PM (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature, 490 (7419), 267−272.DOI:10.1038/nature11401.
1.1.
2012
Scott, RA.; Lagou, V.; Welch, RP.; Wheeler, E.; Montasser, ME.; Luan, J.; Mägi, R.; Strawbridge, RJ.; Rehnberg, E.; Gustafsson, S.; Kanoni, S.; Rasmussen-Torvik, LJ.; Yengo, L.; Lecoeur, C.; Shungin, D.; Sanna, S.; Sidore, C.; Johnson, PC.; Jukema, JW.; Johnson, T. ... Barroso, I. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991−1005.10.1038/ng.2385.
1.1.
2012
Fox, Caroline S; Liu, Yongmei; White, Charles C; Feitosa, Mary; Smith, Albert V; Heard-Costa, Nancy; Lohman, Kurt; Johnson, Andrew D; Foster, Meredith C; Greenawalt, Danielle M; Griffin, Paula; Ding, Jinghong; Newman, Anne B; Tylavsky, Fran; Miljkovic, Iva; Kritchevsky, Stephen B; Launer, Lenore; Garcia, Melissa; Eiriksdottir, Gudny; Carr, J Jeffrey ... GLGC, Consortium. (2012). Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. Plos Genetics, 8 (5), e1002695−e1002695.10.1371/journal.pgen.1002695.
1.1.
2012
Verhoeven, Virginie J M; Hysi, Pirro G; Saw, Seang-Mei; Vitart, Veronique; Mirshahi, Alireza; Guggenheim, Jeremy A; Cotch, Mary Frances; Yamashiro, Kenji; Baird, Paul N; Mackey, David A; Wojciechowski, Robert; Ikram, M Kamran; Hewitt, Alex W; Duggal, Priya; Janmahasatian, Sarayut; Khor, Chiea-Chuen; Fan, Qiao; Zhou, Xin; Young, Terri L; Tai, E-Shyong ... Klaver, Caroline C W. (2012). Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Human Genetics, 131 (9), 1467−1480.10.1007/s00439-012-1176-0.
1.1.
2012
Ellis, JW.; Chen, MH.; Foster, MC.; Liu, CT.; Larson, MG.; de Boer, I.; Kottgen, A.; Parsa, A.; Bochud, M.; Boger, CA.; Kao, L.; Fox, CS.; O'Seaghdha, CM; CKDGen, Consortium ; CARe Renal, Consortium. (2012). Validated SNPs for eGFR and their associations with albuminuria. Human Molecular Genetics, 21 (14), 3293−3298.10.1093/hmg/dds138.
1.1.
2012
Parts, L.; Hedman, AK.; Keildson, S.; Knights, AJ.; Abreu-Goodger, C.; van de Bunt, M.; Guerra-Assuncao, JA.; Bartonicek, N.; van Dongen, S.; Mägi, R.; Nisbet, J.; Barrett, A.; Rantalainen, M.; Nica, AC.; Quail, MA.; Small, KS.; Glass, D.; Enright, AJ.; Winn, J.; Deloukas, P. ... Lindgren, CM. (2012). Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue. Plos Genetics, 8 (5), e1002704−e1002704.10.1371/journal.pgen.1002704.
1.1.
2012
Taal, HR.; St Pourcain, B.; Thiering, E.; Das, S.; Mook-Kanamori, DO.; Warrington, NM.; Kaakinen, M.; Kreiner-Moller, E.; Bradfield, JP.; Freathy, RM.; Geller, F.; Guxens, M.; Cousminer, DL.; Kerkhof, M.; Timpson, NJ.; Ikram, MA.; Beilin, LJ.; Bonnelykke, K.; Buxton, JL.; Charoen, P. ... DeCarli, C. (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5), 532−538.10.1038/ng.2238.
1.1.
2012
Ikram, MA.; Fornage, M.; Smith, AV.; Seshadri, S.; Schmidt, R.; Debette, S.; Vrooman, HA.; Sigurdsson, S.; Ropele, S.; Taal, HR.; Mook-Kanamori, DO.; Coker, LH.; Longstreth, WT.; Niessen, WJ.; DeStefano, AL.; Beiser, A.; Zijdenbos, AP.; Struchalin, M.; Jack, CR.; Rivadeneira, F. ... Wilson, JF. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5), 539−544.10.1038/ng.2245.
1.1.
2012
Manning, AK.; Hivert, MF.; Scott, RA.; Grimsby, JL.; Bouatia-Naji, N.; Chen, H.; Rybin, D.; Liu, CT.; Bielak, LF.; Prokopenko, I.; Amin, N.; Barnes, D.; Cadby, G.; Hottenga, JJ.; Ingelsson, E.; Jackson, AU.; Johnson, T.; Kanoni, S.; Ladenvall, C.; Lagou, V. ... Langenberg, C. (2012). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44 (6), 659−669.10.1038/ng.2274.
1.1.
2012
Bradfield, JP.; Taal, HR.; Timpson, NJ.; Scherag, A.; Lecoeur, C.; Warrington, NM.; Hypponen, E.; Holst, C.; Valcarcel, B.; Thiering, E.; Salem, RM.; Schumacher, FR.; Cousminer, DL.; Sleiman, PMA.; Zhao, JH.; Berkowitz, RI.; Vimaleswaran, KS.; Jarick, I.; Pennell, CE.; Evans, DM. ... Grant, SFA. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44 (5), 526−531.10.1038/ng.2247.
1.1.
2012
Pattaro, C.; Köttgen, A.; Teumer, A.; Garnaas, M.; Boger, CA.; Fuchsberger, C.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Fox, CS. (2012). Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function. Plos Genetics, 8 (3), e1002584−e1002584.10.1371/journal.pgen.1002584.
1.1.
2012
Yang, J; Ferreira, T; Morris, AP; Medland, SE; GIANT, consortium; DIAGRAM, consortium; Madden, PAF; Heath, AC; Martin, NG; Montgomery, GW; Weedon, MN; Loos, RJ; Frayling, TM; McCarthy, MI; Hirschhorn, JN; Goddard, ME; Visscher, PM. (2012). Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nature Genetics, 44, 369−375.
1.1.
2012
Dastani, Z; Hivert, M-F; Timpson, N; Perry, JRB; Yuan, X; Scott, RA; Henneman, P; Heid, IM; Kizer, JR; Lyytikäinen, L-P; et, al. (2012). Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals. Plos Genetics, 8 (3), e1002607−e1002607.
1.1.
2012
Min, Josine L.; Nicholson, George; Halgrimsdottir, Ingileif; Almstrup, Kristian; Petri, Andreas; Barrett, Amy; Travers, Mary; Rayner, Nigel W.; Mägi, Reedik; Pettersson, Fredrik H.; Broxholme, John; Neville, Matt J.; Wills, Quin F.; Cheeseman, Jane; The GIANT, Consortium; The MolPAGE, Consortium; Allen, Maxine; Holmes, Chris C.; Spector, Tim D.; Fleckner, Jan ... Zondervan, Krina T. (2012). Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes. Plos Genetics, 8 (2), e1002505−e1002505.
1.1.
2012
Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N ... Sladek, Robert (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE, 7 (1), e29202−e29202.
5.1.
2012
Mägi, R; Morris, AP. (2012). Genome-wide association analysis of rare variants identifies potential novel susceptibility genes for type 1 diabetes and coronary artery disease. ANNALS OF HUMAN GENETICS, 76: European Mathematical Genetics Meeting, Gottingen, GERMANY, APR 12-13, 2012. Wiley-Blackwell, 421−422.
5.1.
2012
Mägi, R; Horikoshi, M; Surakka, I; Wiltshire, S; Sarin, AP; Mahajan, A; Marullo, L; Ferreira, T; Hagg, S; Ried, JS; Winkler, T; Thorleifsson, G; Tsernikova, N; Esko, T; Willenborg, C; Nelson, CP; Beekman, M; Willems, SM; McCarthy, MI; Morris, AP ... Prokopenko, I. (2012). Large-scale Genome-wide Association Meta-analysis Using Imputation from 2188-haplotype 1000 Genomes Reference Panel Identifies Novel Susceptibility Loci for Anthropometric and Glycemic Traits. GENETIC EPIDEMIOLOGY, 36: Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Stevenson, WA, OCT 18-20, 2012. Wiley-Blackwell, 776−777. (7).
5.1.
2012
Dimas, A.S.; Gomes, V.I.; Knowles, J.; Mägi, R.; Barker, A.; Hivert, M.-F.; Benazzo, A.; Rybin, D.; Assimes, T.I.; Ouertermous, T.; Walker, M.; Florez, J.C.; Barroso, I.; Langenberg, Cl.; Dupuis, J.; Watanabe, R.; McCarthy, M.; Ingelsson, E.; Prokopenko, I. (2012). Impact of Type 2 Diabetes Susceptibility Loci on Variation in Physiologic Glycaemic Traits in Non-Diabetic Individuals. Circulation, 126: AHA Scientific Session 2012, Los Angeles, USa, 3-7. Nov.. Lippincott Williams & Wilkins, 14977. (21).
1.1.
2011
Bailey-Wilson, JE.; Brennan, JS.; Bull, SB.; Culverhouse, R.; Kim, Y.; Jiang, Y.; Jung, JS.; Li, Q.; Lamina, C.; Liu, Y.; Magi, R.; Niu, YS.; Simpson, CL.; Wang, LB.; Yilmaz, YE.; Zhang, HP.; Zhang, ZG. (2011). Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data. Genetic Epidemiology, 35, S92−S100.
1.1.
2011
Chambers, JC; Zhang, WH; Sehmi, J; Li, XZ; Wass, MN; Van der Harst, P; Holm, H; Sanna, S; Kavousi, M; Baumeister, SE; Coin, LJ; Deng, GH; Gieger, C; Heard-Costa, NL; et, al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43 (11), 1131−1138.10.1038/ng.970.
1.1.
2011
Gieger, C; Radhakrishnan, A; Cvejic, A; Tang, WH; Porcu, E; Pistis, G; Serbanovic-Canic, J; Elling, U; Goodall, AH; Labrune, Y; Lopez, LM; Magi, R; Meacham, S; Okada, Y; Pirastu, N; Sorice, R; Teumer, A; Voss, K; Zhang, WH; Ramirez-Solis, R ... Soranzo, N (2011). New gene functions in megakaryopoiesis and platelet formation. Nature, 480 (7376), 201−208.
1.1.
2011
Metspalu, M.; Romero, IG.; Yunusbayev, B.; Chaubey, G.; Mallick, CB.; Hudjashov, G.; Nelis, M.; Mägi, R.; Metspalu, E.; Remm, M.; Pitchappan, R.; Singh, L.; Thangaraj, K.; Villems, R.; Kivisild, T. (2011). Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia. American Journal of Human Genetics, 89 (6), 731−44.10.1016/j.ajhg.2011.11.010.
1.1.
2011
Strawbridge, RJ; Dupuis, J; Prokopenko, I; Barker, A; Ahlqvist, E; Rybin, D; Petrie, JR; Travers, ME; Bouatia-Naji, N; Dimas, AS; Nica, A; Wheeler, E; Chen, H; Voight, BF; Taneera, J; Kanoni, S; Peden, JF; Turrini, F; Gustafsson, S; Zabena, C ... Florez, JC. (2011). Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes, 60 (10), 2624−2634.10.2337/db11-0415.
1.1.
2011
Zhu, H.; Shyh-Chang, N.; Segrè, AV.; Shinoda, G.; Shah, SP.; Einhorn, WS.; Takeuchi, A.; Engreitz, JM.; Hagan, JP.; Kharas, MG.; Urbach, A.; Thornton, JE.; Triboulet, R.; Gregory, RI.; DIAGRAM, Consortium; MAGIC, Investigators; Altshuler, D.; Daley, GQ. (2011). The Lin28/let-7 axis regulates glucose metabolism. Cell, 147 (1), 81−94.
1.1.
2011
Chaubey, Gyaneshwer; Metspalu, Mait; Choi, Ying; Mägi, Reedik; Gallego Romero, Irene; Soares, Pedro; van Oven, Mannis; Behar, Doron M; Rootsi, Siiri; Hudjashov, Georgi; Basu Mallick, Chandana; Karmin, Monika; Nelis, Mari; Parik, Jüri; Goverdhana Reddy, Alla; Metspalu, Ene; vanDriem, George; Xue, Yali; Tyler-Smith, Chris; Thangaraj, Kumarasamy ... Kivisild, Toomas. (2011). Population Genetic Structure in Indian Austroasiatic speakers: The Role of Landscape Barriers and Sex-specific Admixture. Molecular Biology and Evolution, 28(2), 1013−24.
1.1.
2011
Speliotes, EK; Yerges-Armstrong, LM; Wu, J; Hernaez, R; Kim, LJ; Palmer, CD; Gudnason, V; Eiriksdottir, G; Garcia, ME; Launer, LJ; Nalls, MA; Clark, JM; Mitchell, BD; Shuldiner, AR; NASH, CRN; GIANT, Consortium; MAGIC, Investigators; GOLD, Consortium (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. Plos Genetics, 7 (3), e1001324.10.1371/journal.pgen.1001324.
1.1.
2011
Kilpelaeinen, TO; den Hoed, M; Ong, KK; Grontved, A; Brage, S; Jameson, K; Cooper, C; Khaw, KT; Ekelund, U; Wareham, NJ; Loos, RJF; Early Growth Genetics Consortium, incl. Magi R (2011). Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 (4), 851−860.
1.1.
2011
The International Consortium for Blood Pressure Genome-Wide Association Studies, incl. Sõber, S.; Snieder, H.; Org, E.; Veldre, G.; Viigimaa, M.; Laan, M. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478 (7367), 103−109.10.1038/nature10405.
1.1.
2011
Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Johnson, A.D.; Bochud, M.; Rice, K.M.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C. ... Metspalu, A. et al (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics, 43, 1005−1011.10.1038/ng.922.
1.1.
2011
Yang, J.; Weedon, M.N.; Purcell, S.; Lettre, G.; Estrada, K.; Willer, C.J.; Smith, A.V.; Ingelsson, E.; O'Connell, J.R.; Mangino, M.; Mägi, R.; Madden, P.A.; Heath, A.C.; Nyholt, D.R.; Martin, N.G.; Montgomery, G.W.; Frayling, T.M.; Hirschhorn, J.N.; McCarthy, M.I.; Goddard, M.E. ... Visscher, P.M. (2011). Genomic inflation factors under polygenic inheritance. European Journal of Human Genetics, 19, 807−812.10.1038/ejhg.2011.39.
1.1.
2011
Sulem, P.; Gudbjartsson, D. F.; Geller, F.; Prokopenko, I.; Feenstra, B.; Aben, K.K.H.; Franke, B.; den Heijer, M.; Kovacs, P.; Stumvoll, M.; Mägi, R.; Yanek, L.R.; Becker, L.C.; Boyd, H.A.; Stacey, S.N.; Bragi Walters, G.; Jonasdottir, A.; Thorleifsson, G.; Holm, H.; Gudjonsson, S.A. ... Stefansson, K. (2011). Sequence variants at CYP1A1–CYP1A2 and AHR associate with coffee consumption. Human Molecular Genetics, 20 (10), 2071−2077.
1.1.
2011
Böger, CA; Chen, MH; Tin, A; Olden, M; Köttgen, A; de Boer, IH; Fuchsberger, C; O’Seaghdha, CM; Pattaro, C; Teumer, A; et, al. (2011). CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology, 22, 555−570.
1.1.
2011
Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
1.2.
2011
Mägi, R.; Kumar, A.; Morris, AP. (2011). Assessing the impact of missing genotype data in rare variant association analysis. BMC Proceedings, 9 (5), S107−S107.
1.1.
2010
Nettleton, JA; McKeown, NM; Kanoni, S; Lemaitre, RN; Hivert, MF; Ngwa, J; van Rooij, FJA; Sonestedt, E; Wojczynski, MK; Ye, Z; Tanaka, T; CHARGE, Whole Grain Foods Study Grp incl. Mägi, R. (2010). Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies. Diabetes Care, 33 (12), 2684−2691.
1.1.
2010
Speliotes, E.K.; Willer, C.J.; Berndt, S.I.; Monda, K.L.; Thorleifsson, G.; Jackson, A.U.; Allen, H.L.; Lindgren, C.M.; Luan, J.; Mägi, R.; Randall, J.C.; Vedantam, S.; Winkler, T.W.; Workalemahu, T.; Heid, I.M.; Qi, L.; Steinthorsdottir, V.; Weedon, M.N.; Wheeler, E.; Wood, A.R. ... Hayward, C. (2010). Genome-wide association study of 249,796 individuals reveals eighteen loci associated with body mass index. Nature Genetics, 11, 937−948.10.1038/ng.686.
1.1.
2010
Soranzo, Nicole; Sanna, Serena; Wheeler, Eleanor; Gieger, Christian; Radke, Dörte; Dupuis, Josée; Bouatia-Naji, Nabila; Langenberg, Claudia; Prokopenko, Inga; Stolerman, Elliot; Sandhu, Manjinder S; Heeney, Matthew M; Devaney, Joseph M; Reilly, Muredach P; Ricketts, Sally L; Stewart, Alexandre FR; Voight, Benjamin F; Willenborg, Christina; Wright, Benjamin; Altshuler, David ... Meigs, James B (2010). Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes, 59 (12), 3229−3239.10.2337/db10-0502.
1.1.
2010
Mägi, Reedik; Lindgren, Cecilia M.; Morris, Andrew P. (2010). Meta-analysis of sex-specific genome-wide association studies. Genetic Epidemiology, 34 (8), 846−853.10.1002/gepi.20540.
1.1.
2010
Lango Allen, Hana; Estrada, Karol; Lettre, Guillaume; Berndt, Sonja I; Weedon, Michael N; Rivadeneira, Fernando; Willer, Cristen J; Jackson, Anne U; Vedantam, Sailaja; Raychaudhuri, Soumya; Ferreira, Teresa; Wood, Andrew R; Weyant, Robert J; Segre, Ayellet V; Speliotes, Elizabeth K; Wheeler, Eleanor; Soranzo, Nicole; Park, Ju-Hyun; Yang, Jian; Gudbjartsson, Daniel ... Hirschhorn, Joel N (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467 (7317), 832−838.
1.1.
2010
Oitmaa, E.; Peters, M.; Vaidla, K.; Andreson, R.; Mägi, R.; Slavin, G.; Velthut, .; Tõnisson, N.; Reimand, T.; Remm, M.; Schneider, M.; Õunap, K.; Salumets, A.; Metspalu, A. (2010). Molecular diagnosis of Down Syndrome using Quantitative APEX-2 microarrays. Prenatal Diagnosis, 30, 1170−1177.
1.1.
2010
Dupuis, J.; Langenberg, C.; Prokopenko, I.; Saxena, R.; Soranzo, N.; Jackson, A.U.; Wheeler, E.; Glazer, N.L.; Bouatia-Naji, N.; Gloyn, A.L.; Lindgren, C.M.; Mägi, R.; Morris, A.P.; Randall, J.; Johnson, T.; Elliott, P.; Rybin, D.; Thorleifsson, G.; Steinthorsdottir, V.; Henneman, P. ... Mitchell, B.D (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42 (2), 105−116.10.1038/ng.520.
1.1.
2010
Mägi, R; Morris, AP. (2010). GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics, 11 (288), 288.10.1186/1471-2105-11-288.
1.1.
2010
Ingelsson, E.; Langenberg, C.; Hivert, M.F.; Prokopenko, I.; Lyssenko, V.; Dupuis, J.; Mägi, R.; Sharp, S.; Jackson, A.U.; Assimes, T.L.; Shrader, P.; Knowles, J.W.; Zethelius, B.; Abbasi, F.A.; Bergman, R.N.; Bergmann, A.; Berne, C.; Boehnke, M.; Bonnycastle, L.L.; Bornstein, S.R. ... Florez, JC. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. DIABETES, 59: 59th Annual Meeting of the American-Society-of-Human-Genetics; Honolulu, HI, USA; OCT 20-24, 2009. 1266−1275. (5).10.2337/db09-1568.
1.1.
2010
Freathy, R.M.; Mook-Kanamori, D.O.; Sovio, U.; Prokopenko, I.; Timpson, N.J.; Berry, D.J.; Warrington, N.M.; Widen, E.; Hottenga, J.J.; Kaakinen, M.; Lange, L.A.; Bradfield, J.P.; Kerkhof, M.; Marsh, J.A.; Mägi, R.; et, al. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 (5), 430−435.
1.1.
2010
Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; et, al.; Mägi, R.; et, al. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42 (5), 376−384.10.1038/ng.568.
1.1.
2010
Thorgeirsson, TE.; Gudbjartsson, DF.; Surakka, I.; Vink, JM.; Amin, N.; Geller, F.; Sulem, P.; Rafnar, T.; Esko, T.; Walter, S.; Gieger, C.; Rawal, R.; Mangino, M.; Prokopenko, I.; Mägi, R.; Keskitalo, K.; Gudjonsdottir, IH.; Gretarsdottir, S.; Stefansson, H.; Thompson, JR. ... Stefansson, K (2010). Sequence variants at CHRNB3-CHRNA6 and affect smoking behavior. Nature Genetics, 42 (5), 448−453.
5.1.
2010
Mägi, R.; Hottenga, J. J.; Prokopenko, I. (2010). A genome-wide association analysis of over 75,000 individuals identifies gender-specific effects for fasting glycaemic traits. Diabetologia, 53: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, SWEDEN, SEP 20-24, 2010. Springer, S28−S28.
5.1.
2010
Mägi, R; Morris, AP. (2010). GRANVIL: Rare Variant Analysis of Genome-Wide Association Studies. Genetic Epidemiology, 34: 19th Annual Meeting of the International-Genetic-Epidemiology-Society, Boston, MA, OCT 10-12, 2010. Wiley-Blackwell, 926−926. (8).
1.1.
2009
Nelis, M.; Esko, T.; Mägi, R.; Zimprich, F.; Zimprich, A.; Toncheva, D.; Karachanak, S.; Piskácková, T.; Balascák, I.; Peltonen, L.; Jakkula, E.; Rehnström, K.; Lathrop, M.; Heath, S.; Galan, P.; Schreiber, S.; Meitinger, T.; Pfeufer, A.; Wichmann, HE.; Melegh, B. ... Metspalu, A. (2009). Genetic structure of Europeans: a view from the North-East. PLoS ONE, 4(5), e5472.
5.1.
2009
Prokopenko, I; Dupuis, J; Langenberg, C; Saxena, R; Soranzo, N; Jackson, AU; Wheeler, E; Glazer, NL; Mägi, R; Bouatia-Naji, N; Florez, JC; Barroso, I. (2009). Novel genetic loci implicated in fasting glucose homeostasis and their impact on related metabolic traits. Diabetologia, 52: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, AUSTRIA, SEP 30-OCT 02, 2009.. Springer, S38−S38.
1.1.
2008
Krjutskov, K.; Andreson, R.; Mägi, R.; Nikopensius, T.; Khrunin, A.; Mihailov, E.; Tammekivi, V.; Sork, H.; Remm, M.; Metspalu, A. (2008). Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays. Nucleic Acids Research, 36 (12), e75.
1.1.
2008
Tamm, R.; Oselin, K.; Kallassalu, K.; Magi, R.; Anier, K.; Remm, M.; Metspalu, A. (2008). Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population. Clinical Chemistry and Laboratory Medicine, 46 (7), 974−979.
5.2.
2008
Oitmaa, Eneli; Krjutskov, Kaarel; Mägi, Reedik ; Andreson, Reidar ; Raukas, Elve; Remm, Maido; Tõnisson, Neeme; Schneider, Marion; Metspalu, Andres (2008). Molecular diagnostics of Down syndrome using quantitative APEX microarrays. RBM online, vol.16-suppl. 3: Eighth International Symposium of Preimplantation Genetic Diagnosis, Barcelona, April 23-26, 2008. S17.
1.1.
2007
Magi, R.; Pfeufer, A.; Nelis, M.; Montpetit, A.; Metspalu, A.; Remm, M. (2007). Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. BMC Genomics, 8 (159), x.
1.1.
2007
Kuningas, M.; Mägi, R.; Westendorp, R.G.; Slagboom, P.E.; Remm, M.; van Heemst, D. (2007). Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. European Journal of Human Genetics, 15 (3), 294−301.10.1038/sj.ejhg.5201766.
1.1.
2006
Kaminski, S.; Brym, P.; Rusc, A.; Wojcik, E.; Ahman, A.; Mägi, R. (2006). Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (APEX) microarray. Animal biotechnology, 17 (1), 1−11.
1.1.
2006
Montpetit, A.; Nelis, M.; Laflamme, P.; Magi, R.; Ke, X.Y.; Remm, M.; Cardon, L.; Hudson, T.J.; Metspalu, A. (2006). An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. Plos Genetics, 2 (3), 282−290.
3.2.
2006
Mägi, R.; Kaplinski, L.; Remm, M. (2006). The Whole Genome TagSNP Selection and Transferability Among HapMap Populations. Pacific Symposium on Biocomputing 2006: 2006. World Scientific Publ Co Pte Ltd, 535−543.
1.1.
2005
Mueller, J. C.; Lõhmussaar, E.; Mägi, R.; Remm, M.; Bettecken, T.; Lichtner, P.; Huber, S.; Illig, T; Luedemann, J.; Schreiber, S.; Wichmann, H. E.; Pramstaller, P.; Romeo, G.; Testa, A.; Metspalu, A.; Meitinger, T. (2005). Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations. American Journal of Human Genetics, 76 (3), 387−398.
1.1.
2002
Liira, J.; Zobel, K.; Magi, R.; Molenberghs, G. (2002). Vertical structure of herbaceous canopies: the importance of plant growth-form and species-specific traits. Plant Ecology, 163 (1), 123−134.
1.1.
2002
Dawson, E.; Abecasis, GR.; Bumpstead, S.; Chen, Y.; Hunt, S.; Beare, DM.; Pabial, J.; Dibling, T.; Tinsley, E.; Kirby, S.; Carter, D.; Papaspyridonos, M.; Livingstone, S.; Ganske, R.; Lohmmussaar, E.; Zernant, J.; Tonisson, N.; Remm, M.; Magi, R.; Puurand, T. ... Dunham, I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature, 418 (6897), 544−548.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using APEX arrays. European Journal of Human Genetics, 10, 299−299.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Puurano, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using Arrayed Primer EXtension (APEX) technology. American Journal of Human Genetics, 71 (4), 449−449.
5.1.
2001
Metspalu, A.; Zernant, J.; Lohmussaar, E.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, L.; Pavel, H.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M. (2001). SNP analysis of the human chromosome 22 using APEX arrays. American Journal of Human Genetics, 69 (4), 408−408.

Tööstusomand

14.10.2019

Reedik Mägi

https://www.etis.ee/CV/Reedik_Mägi/eng
18.08.1978
737 4045
reedik.magi@ut.ee

Career

Institution(s) and position(s)
19.08.2019–...   
University of Tartu, Institute of Genomics, Research Professor in Bioinformatics (1,00)
01.01.2018–18.08.2019   
University of Tartu, Institute of Genomics, Senior Research Fellow in Bioinformatics (1,00)
01.09.2016–31.12.2017   
University of Tartu, Estonian Genome Center , Senior Research Fellow in Bioinformatics (1,00)
01.09.2011–31.08.2016   
University of Tartu, Estonian Genome Center , Senior Research Fellow (1,00)
01.02.2010–31.08.2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow (0,10)
2009–2011   
University Of Oxford, Marie Curie Research Fellow in Wellcome Trust Centre for Human Genetics (1,00)
01.09.2008–31.08.2011   
Estonian Biocentre, Extraordinary Researcher (0,10)
01.04.2008–31.01.2010   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow extraordinarius (0,10)
2008–2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Chair of Bioinformatics, Extraordinary Researcher (0,10)
2008–2009   
University Of Oxford, Senior Statistical Geneticist (1,00)
01.01.2008–31.12.2011   
Wellcome Trust Centre for Human Genetics, University of Oxford; postdoc
01.01.2008–31.03.2008   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow extraordinarius (1,00)
01.12.2007–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.08.2007–30.11.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,10)
01.02.2007–31.07.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.09.2006–31.01.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.07.2006–31.08.2006   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.09.2005–30.06.2006   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.07.2005–31.08.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.02.2005–30.06.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.02.2004–31.01.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
2004–2008   
University of Tartu, University of Tartu, scientist (0,50)
01.01.2002–2004   
Biodata Ltd, Biodata Ltd., IT specialist (0,50)
01.01.2000–31.12.2002   
Asper Biotech Ltd., IT specialist
 
 
Education
2003–2007   
University of Tartu, PhD stud. of bioinformatics
2000–2003   
University of Tartu, MSc of plant ecology
1996–2000   
University of Tartu, BS of botany and ecology
 
 
R&D related managerial and administrative work
2016−...   
Co-leader of annual "Introduction to the statistical analysis of genome-wide association studies" course in Imperial College of London, UK
2017−2017   
Organizer and the member of scientific committee of of "European Mathematical Genetics Meeting"

Qualifications

Academic degrees
Reedik Mägi, Doctor's Degree, 2007, (sup) Maido Remm, The Linkage Disequilibrium And The Selection of Genetic markers For Association Studies in European Populations, University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology.
Reedik Mägi, Research Master's Degree, 2003, (sup) Kristjan Zobel, Rohu- ja puhmarinde võra struktuur 27 Eesti niidu- ja metsakoosluses, University of Tartu, Faculty of Biology and Geography, Institute of Botany and Ecology.
 
 
Honours & awards
2019, Reedik Mägi, National Science Award in chemistry and molecular biology for the series of works "Basic research on genetics and genomics for the implementation of personal medicine in Estonia" (Esko, Mägi, Fischer, Milani)
2009, Reedik Mägi, EC FP7 Marie Curie IEF (2009-2011)
2008, Reedik Mägi, Post-doctoral fellowship from Estonian Biocentre (ECOGENE)
 
 
Field of research
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine; CERCS SPECIALITY: B100 History and philosophy of biomedical sciences, theoretical biology, general aspects of evolution ; SPECIALITY: Main scientific interests include population and statistical genetics, as well as software development for implementing statistical methods for genetic studies. I have worked on the development and implementation of methodology of meta-analysis, rare-variant analysis, and sequencing data analysis. I am also participating in several association studies, which are mainly related to T2D and various anthropometric phenotypes.
 
 

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F; Feufer, Arne P; Marullo, Letizia; Mägi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in medicine.10.2217/bmm-2017-0431 [forthcoming].
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in medicine, 1−8.10.1038/s41436-018-0311-2 [forthcoming].
1.1.
2019
Reisberg, Sulev; Galwey, Nicholas; Avillach, Paul; Sahlqvist, Anna-Stina; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Vilo, Jaak; James, Glen (2019). Comparison of variation in frequency for SNPs associated with asthma or liver disease between Estonia, HapMap populations and the 1000 genome project populations. International Journal of Immunogenetics, 46 (1), 1−10.10.1111/iji.12413.
1.1.
2019
Tasa, T.; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 27 (3), 442−454.10.1038/s41431-018-0300-6.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, in press.10.1111/eva.12780 [forthcoming].
1.1.
2019
de Vries, Paul S; Brown, Michael R; Bentley, Amy R; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C (2019). Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology.10.1093/aje/kwz005 [forthcoming].
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648.10.1038/s41588-019-0378-y.
1.1.
2019
Saag, Lehti; Laneman, Margot; Varul, Liivi; Malve, Martin; Valk, Heiki; Razzak, Maria A.; Shirobokov, Ivan G.; Khartanovich, Valeri I.; Mikhaylova, Elena R.; Kushniarevich, Alena; Scheib, Christiana Lyn; Solnik, Anu; Reisberg, Tuuli; Parik, Juri; Saag, Lauri; Metspalu, Ene; Rootsi, Siiri; Montinaro, Francesco; Remm, Maido; Magi, Reedik ... Tambets, Kristiina (2019). The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East. Current Biology, 29 (10), 1701−1728.10.1016/j.cub.2019.04.026.
1.1.
2019
Justice, Anne E; Karaderi, Tugce; Highland, Heather M; Young, Kristin L; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L; Fine, Rebecca S; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W; Locke, Adam E; Medina-Gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush ... Lindgren, Cecilia M (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51 (3), 452−469.10.1038/s41588-018-0334-2.
1.1.
2019
Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; ,; ,; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D ... Vrieze, Scott (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51 (2), 237−244.10.1038/s41588-018-0307-5.
1.1.
2019
Bovijn, Jonas; Jackson, Leigh; Censin, Jenny; Chen, Chia-Yen; Laisk, Triin; Laber, Samantha; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Smoller, Jordan W; Harrison, Jamie W; Ruth, Katherine S; Beaumont, Robin N; Jones, Samuel E; Tyrrell, Jessica; Wood, Andrew R; Weedon, Michael N; Mägi, Reedik; Neale, Benjamin; Lindgren, Cecilia M ... Holmes, Michael V (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. American Journal of Human Genetics, 104 (1), 157−163.10.1016/j.ajhg.2018.11.004.
1.1.
2019
Wiberg, Akira; Ng, Michael; Schmid, Annina B.; Smillie, Robert W.; Baskozos, Georgios; Holmes, Michael V.; Kunnapuu, K.; Magi, R.; Bennett, David L.; Furniss, Dominic (2019). A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nature Communications, 10, ARTN 1030.10.1038/s41467-019-08993-6.
1.1.
2019
James, Glen; Reisberg, Sulev; Lepik, Kaido; Galwey, Nicholas; Avillach, Paul; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Alexander, Myriam; Waterworth, Dawn; Loomis, A. Katrina; Vilo, Jaak (2019). An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank. PLOS ONE, 14 (4), e0215026.10.1371/journal.pone.0215026.
1.1.
2019
Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B.; Feitosa, Mary F.; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y.; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O.; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar ... Pattaro, Cristian (2019). A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51 (6), 957−976.10.1038/s41588-019-0407-x.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
1.1.
2018
Pervjakova, N.; Kukushkina, V.; Haller, T.; Kasela, S.; Joensuu, A.; Kristiansson, K.; Annilo, T.; Perola, M.; Salomaa, V.; Jousilahti, P.; Metspalu, A.; Magi, R. (2018). Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene. Biomarkers in medicine, 12 (5), 439−446.10.2217/bmm-2018-0020.
1.1.
2018
Suhorutshenko, Marina; Kukushkina, Viktorija; Velthut-Meikas, Agne; Altmäe, Signe; Peters, Maire; Mägi, Reedik; Krjutškov, Kaarel; Koel, Mariann; Codoñer, Francisco; Martinez-Blanch, Juan; Vilella, Felipe; Simón, Carlos; Salumets, Andres; Laisk, Triin (2018). Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. Human Reproduction, 33 (11), 2074−2086.10.1093/humrep/dey301.
1.1.
2018
Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
1.1.
2018
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
1.1.
2018
Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. Jornal Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
1.1.
2018
Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516.10.1038/s41588-018-0241-6.
1.1.
2018
Pasman, Joëlle A; Verweij, Karin J H; Gerring, Zachary; Stringer, Sven; Sanchez-Roige, Sandra; Treur, Jorien L; Abdellaoui, Abdel; Nivard, Michel G; Baselmans, Bart M L; Ong, Jue-Sheng; Ip, Hill F; van der Zee, Matthijs D; Bartels, Meike; Day, Felix R; Fontanillas, Pierre; Elson, Sarah L; ,; de Wit, Harriet; Davis, Lea K; MacKillop, James ... Vink, Jacqueline M (2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21 (9), 1161−1170.10.1038/s41593-018-0206-1.
1.1.
2018
Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429.10.1038/s41588-018-0205-x.
1.1.
2018
Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571.10.1038/s41588-018-0084-1.
3.1.
2018
Vals, M.A.; Pajusalu, S.; Kals, M.; Mägi, R.; Õunap, K. (2018). The Prevalence of PMM2-CDG in Estonia Based on Population Carrier Frequencies and Diagnosed Patients. JIMD Reports, 39, 13−17.10.1007/8904_2017_41.
6.8.
2018
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez ... McCarthy, Mark I (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5, 180002−180002.10.1038/sdata.2018.2.
6.8.
2018
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael ... Caulfield, Mark J (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (12), 1755−1755.10.1038/s41588-018-0297-3.
1.1.
2017
Huan, Tianxiao; Joehanes, Roby; Schurmann, Claudia; Schramm, Katharina; Pilling, Luke C; Peters, Marjolein J; Mägi, Reedik; DeMeo, Dawn; O'Connor, George T; Ferrucci, Luigi; Teumer, Alexander; Homuth, Georg; Biffar, Reiner; Völker, Uwe; Herder, Christian; Waldenberger, Melanie; Peters, Annette; Zeilinger, Sonja; Metspalu, Andres; Hofman, Albert ... Levy, Daniel (2017). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics, 25 (21), 1−33.10.1093/hmg/ddw288.
1.1.
2017
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201.10.1038/mp.2016.71.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 114 (3), E327−E336.10.1073/pnas.1619052114.
1.1.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 3, 403−415.10.1038/ng.3768.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110.10.1186/s12859-017-1530-2.
1.1.
2017
Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25.10.1186/s12859-016-1437-3.
1.1.
2017
R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical pharmacology and therapeutics, 101 (5), 684−695.10.1002/cpt.540.
1.1.
2017
Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186.10.1038/ng.3912.
1.1.
2017
Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. Plos Genetics, 13 (6), e1006812.10.1371/journal.pgen.1006812.
1.1.
2017
Kukushkina, Viktorija; Modhukur, Vijayachitra; Suhorutšenko, Marina; Peters, Maire; Mägi, Reedik; Rahmioglu, Nilufer; Velthut-Meikas, Agne; Altmäe, Signe; Esteban, Francisco J; Vilo, Jaak; Zondervan, Krina; Salumets, Andres; Laisk-Podar, Triin (2017). DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase. Scientific Reports, 7 (1), 3916−3916.10.1038/s41598-017-03682-0.
1.1.
2017
Eichstaedt, Christina A; Pagani, Luca; Antao, Tiago; Inchley, Charlotte E; Cardona, Alexia; Mörseburg, Alexander; Clemente, Florian J; Sluckin, Timothy J; Metspalu, Ene; Mitt, Mario; Mägi, Reedik; Hudjashov, Georgi; Metspalu, Mait; Mormina, Maru; Jacobs, Guy S; Kivisild, Toomas (2017). Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations. Scientific Reports, 7 (1), 13042−13042.10.1038/s41598-017-13382-4.
1.1.
2017
Kraja, Aldi T.; Cook, James P.; Warren, Helen R.; Surendran, Praveen; Liu, Chunyu; Evangelou, Evangelos; Manning, Alisa K.; Grarup, Niels; Drenos, Fotios; Sim, Xueling; Smith, Albert Vernon; Amin, Najaf; Blakemore, Alexandra I. F.; Bork-Jensen, Jette; Brandslund, Ivan; Farmaki, Aliki-Eleni; Fava, Cristiano; Ferreira, Teresa; Herzig, Karl-Heinz; Giri, Ayush ... Howson, Joanna M. M. (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals. Circulation-cardiovascular Genetics, 10 (5), UNSP e001778.10.1161/CIRCGENETICS.117.001778.
1.1.
2017
Mägi, R; Horikoshi, M; Sofer, T; Mahajan, A; Kitajima, H; Franceschini, N; McCarthy, MI; COGENT-Kidney, Consortium; T2D-GENES, Consortium; Morris, AP (2017). Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Human Molecular Genetics, 26 (18), 3639−3650.10.1093/hmg/ddx280.
1.1.
2017
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N. William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez ... McCarthy, Mark I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, ARTN 170179.10.1038/sdata.2017.179.
1.1.
2017
Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish; Emdin, Connor; Alam, Dewan; Alves, Alexessander Couto; Amouyel, Philippe; Di Angelantonio, Emanuele; Arveiler, Dominique; Assimes, Themistocles L.; Auer, Paul L.; Baber, Usman; Ballantyne, Christie M.; Bang, Lia E.; Benn, Marianne; Bis, Joshua C. ... Kathiresan, Sekar (2017). Exome-wide association study of plasma lipids in > 300,000 individuals. Nature Genetics, 49 (12), 1758−1772.10.1038/ng.3977.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994.10.1038/ejhg.2017.90.
1.1.
2017
Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung ... Lindgren, Cecilia M. (2017). A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 66 (7), 2019−2032.10.2337/db16-1329.
1.1.
2017
Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845.10.1038/ng.3841.
1.1.
2017
Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D. ... Kilpelainen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults. PLOS Genetics, 13 (4), ARTN e1006528.10.1371/journal.pgen.1006528.
1.1.
2017
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stančáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179.10.1038/sdata.2017.179.
1.1.
2017
Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia; Gaulton, Kyle J.; Kaakinen, Marika; Pervjakova, Natalia; Pers, Tune H.; Johnson, Andrew D.; Eicher, John D.; Jackson, Anne U.; Ferreira, Teresa; Lee, Yeji; Ma, Clement; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Van Zuydam, Natalie R.; Mahajan, Anubha; Chen, Han ... Prokopenko, Inga (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes, 66 (11), 2888−2902.10.2337/db16-1253.
1.1.
2017
Mitt, Mario; Kals, Mart; Parn, Kalle; Gabriel, Stacey B; Lander, Eric S; Palotie, Aarno; Ripatti, Samuli; Morris, Andrew P; Metspalu, Andres; Esko, Tonu; Magi, Reedik; Palta, Priit; (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. European Journal of Human Genetics, 25 (7), 869−879.10.1038/ejhg.2017.51.
5.1.
2017
Rahmioglu, Nilufer; Lockstone, Helen; Ferreira, Teresa; Magi, Reedik; Van De Bunt, Martijn; Lindgren, Cecilia; Morris, Andrew; Becker, Christian; Zondervan, Krina (2017). Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis. Reproductive Sciences, 24, 205A−206A.
5.1.
2017
Kaakinen, Marika; Magi, Reedik; Lagou, Vasiliki; Claringbould, Annique; Gaulton, Kyle; Fischer, Krista; Morris, Andrew; Prokopenko, Inga (2017). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. Genetic Epidemiology, 41 (7), 652−653.
5.1.
2017
Suhorutshenko, M.; Kukushkina, V.; Velthut-Meikas, A.; Altmae, S.; Maire, P.; Magi, R.; Codoner, F.; Vilella, F.; Simon, C.; Salumets, A.; Laisk-Podar, T. (2017). Transcriptomic profile of early and mid-secretory endometrium revealed by RNA-seq: a paired sample cohort study. FEBS Journal, 284, 134−134.
6.8.
2017
Teumer, A.; Qi, Q.; Nethander, M.; Aschard, H.; Bandinelli, S.; Beekman, M.; Berndt, S. I.; Bidlingmaier, M.; Broer, L.; Cappola, A.; Ceda, G. P.; Chanock, S.; Chen, M. -H.; Chen, T. C.; Chen, Y. -D. I.; Chung, J.; Miglianico, Del Greco F.; Eriksson, J.; Ferrucci, L.; Friedrich, N. ... Kaplan, R. C. (2017). Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016). Aging Cell, 16 (4), 898−898.10.1111/acel.12612.
6.8.
2017
Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Elliott, Paul (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (vol 49, pg 403, 2017). Nature Genetics, 49 (10), 1558−1558.10.1038/ng1017-1558a.
1.1.
2016
Stringer, S; Minică, C C; Verweij, K J H; Mbarek, H; Bernard, M; Derringer, J; van Eijk, K R; Isen, J D; Loukola, A; Maciejewski, D F; Mihailov, E; van der Most, P J; Sánchez-Mora, C; Roos, L; Sherva, R; Walters, R; Ware, J J; Abdellaoui, A; Bigdeli, T B; Branje, S J T ... Vink, J M (2016). Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32 330 subjects from the International Cannabis Consortium. Translational Psychiatry, 6, e769−e769.10.1038/tp.2016.36.
1.1.
2016
Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroula ... Loos, Ruth J F (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7, 10495−10495.10.1038/ncomms10495.
1.1.
2016
Lessard, Samuel; Manning, Alisa K; Low-Kam, Cécile; Auer, Paul L; Giri, Ayush; Graff, Mariaelisa; Schurmann, Claudia; Yaghootkar, Hanieh; Luan, Jian'an; Esko, Tonu; Karaderi, Tugce; Bottinger, Erwin P; Lu, Yingchang; Carlson, Chris; Caulfield, Mark; Dubé, Marie-Pierre; Jackson, Rebecca D; Kooperberg, Charles; McKnight, Barbara; Mongrain, Ian ... Lettre, Guillaume (2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. Human Molecular Genetics, 25 (10), 1−11.10.1093/hmg/ddw055.
1.1.
2016
Pervjakova, Natalia; Kasela, Silva; Morris, Andrew P; Kals, Mart; Metspalu, Andres; Lindgren, Cecilia M; Salumets, Andres; Mägi, Reedik (2016). Imprinted genes and imprinting control regions show predominant intermediate methylation in adult somatic tissues. Epigenomics, 8 (6), 789−799.10.2217/epi.16.8.
1.1.
2016
Okbay, Aysu; Beauchamp, Jonathan P; Fontana, Mark Alan; Lee, James J; Pers, Tune H; Rietveld, Cornelius A; Turley, Patrick; Chen, Guo-Bo; Emilsson, Valur; Meddens, S Fleur W; Oskarsson, Sven; Pickrell, Joseph K; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; Ahluwalia, Tarunveer S; Bacelis, Jonas; Baumbach, Clemens; Bjornsdottir, Gyda ... Benjamin, Daniel J (2016). Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533 (7604), 539−542.10.1038/nature17671.
1.1.
2016
Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P; Manning, Alisa K; Grarup, Niels; Sim, Xueling; Barnes, Daniel R; Witkowska, Kate; Staley, James R; Tragante, Vinicius; Tukiainen, Taru; Yaghootkar, Hanieh; Masca, Nicholas; Freitag, Daniel F; Ferreira, Teresa; Giannakopoulou, Olga; Tinker, Andrew; Harakalova, Magdalena ... Munroe, Patricia B (2016). Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics, 48 (10), 1151−1161.10.1038/ng.3654.
1.1.
2016
Tajuddin, Salman M; Schick, Ursula M; Eicher, John D; Chami, Nathalie; Giri, Ayush; Brody, Jennifer A; Hill, W David; Kacprowski, Tim; Li, Jin; Lyytikäinen, Leo-Pekka; Manichaikul, Ani; Mihailov, Evelin; O'Donoghue, Michelle L; Pankratz, Nathan; Pazoki, Raha; Polfus, Linda M; Smith, Albert Vernon; Schurmann, Claudia; Vacchi-Suzzi, Caterina; Waterworth, Dawn M ... Auer, Paul L (2016). Large-Scale Exome-wide Association Analysis Identifies Loci for White Blood Cell Traits and Pleiotropy with Immune-Mediated Diseases. American Journal of Human Genetics, 99 (1), 22−39.10.1016/j.ajhg.2016.05.003.
1.1.
2016
Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement; Fontanillas, Pierre; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M ... McCarthy, Mark I (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41−47.10.1038/nature18642.
1.1.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8), 856−866.10.1038/ng.3598.
1.1.
2016
Chami, Nathalie; Chen, Ming-Huei; Slater, Andrew J; Eicher, John D; Evangelou, Evangelos; Tajuddin, Salman M; Love-Gregory, Latisha; Kacprowski, Tim; Schick, Ursula M; Nomura, Akihiro; Giri, Ayush; Lessard, Samuel; Brody, Jennifer A; Schurmann, Claudia; Pankratz, Nathan; Yanek, Lisa R; Manichaikul, Ani; Pazoki, Raha; Mihailov, Evelin; Hill, W David ... Lettre, Guillaume (2016). Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. American Journal of Human Genetics, 99 (1), 8−21.10.1016/j.ajhg.2016.05.007.
1.1.
2016
Tšuiko, O.; Nõukas, M.; Žilina, O.; Hensen, K.; Tapanainen, J.; Mägi, R.; Kals, M.; Kivistik, PA.; Haller-Kikkatalo, K.; Salumets, A.; Kurg, A. (2016). Copy number variation analysis detects novel candidate genes involved in follicular growth and oocyte maturation in a cohort of premature ovarian failure cases. Human Reproduction, 31 (8), 1913−1925.10.1093/humrep/dew142.
1.1.
2016
Laisk-Podar, Triin; Lindgren, Cecilia M; Peters, Maire; Tapanainen, Juha S; Lambalk, Cornelis B; Salumets, Andres; Mägi, Reedik (2016). Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond. Trends in endocrinology and metabolism: TEM, 27 (7), 516−528.10.1016/j.tem.2016.04.011.
1.1.
2016
Läll, Kristi; Mägi, Reedik; Morris, Andrew; Metspalu, Andres; Fischer, Krista (2016). Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores. Genetics in medicine, 1−10.10.1038/gim.2016.103.
1.1.
2016
Pagani, Luca; Lawson, Daniel John; Jagoda, Evelyn; Mörseburg, Alexander; Eriksson, Anders; Mitt, Mario; Clemente, Florian; Hudjashov, Georgi; DeGiorgio, Michael; Saag, Lauri; Wall, Jeffrey D; Cardona, Alexia; Mägi, Reedik; Sayres, Melissa A Wilson; Kaewert, Sarah; Inchley, Charlotte; Scheib, Christiana L; Järve, Mari; Karmin, Monika; Jacobs, Guy S ... Metspalu, Mait. (2016). Genomic analyses inform on migration events during the peopling of Eurasia. Nature, 538 (7624), 238−242.10.1038/nature19792.
1.1.
2016
Pattaro, Cristian; Teumer, Alexander; Gorski, Mathias; Chu, Audrey Y; Li, Man; Mijatovic, Vladan; Garnaas, Maija; Tin, Adrienne; Sorice, Rossella; Li, Yong; Taliun, Daniel; Olden, Matthias; Foster, Meredith; Yang, Qiong; Chen, Ming-Huei; Pers, Tune H; Johnson, Andrew D; Ko, Yi-An; Fuchsberger, Christian; Tayo, Bamidele ... Fox, Caroline S (2016). Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nature Communications, 7 (10023), 10023−10023.10.1038/ncomms10023.
1.1.
2016
Inchley, Charlotte E; Larbey, Cynthia D A; Shwan, Nzar A A; Pagani, Luca; Saag, Lauri; Antão, Tiago; Jacobs, Guy; Hudjashov, Georgi; Metspalu, Ene; Mitt, Mario; Eichstaedt, Christina A; Malyarchuk, Boris; Derenko, Miroslava; Wee, Joseph; Abdullah, Syafiq; Ricaut, François-Xavier; Mormina, Maru; Mägi, Reedik; Villems, Richard; Metspalu, Mait ... Kivisild, Toomas (2016). Selective sweep on human amylase genes postdates the split with Neanderthals. Scientific Reports, 6, 37198−37198.10.1038/srep37198.
1.1.
2016
Ganna A, Genovese G, Howrigan DP, Byrnes A, Kurki MI, Zekavat SM, Whelan CW, Kals M, Nivard MG, Bloemendal A, Bloom JM, Goldstein JI, Poterba T, Seed C, Handsaker RE, Natarajan P, Mägi R, Gage D, Robinson EB, Metspalu A, Salomaa V, Suvisaari J, Purcell SM, Sklar P, Kathiresan S, Daly MJ, McCarroll SA, Sullivan PF, Palotie A, Esko T, Hultman CM, Neale BM. (2016). Ultra-rare disruptive and damaging mutations influence educational attainment in the general population. Nature Neuroscience, 19 (12), 1563−1565.10.1038/nn.4404.
1.1.
2016
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stančáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D'Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N, Graff M, Grallert H, Grarup N, Gräßler J, Grewal J, Hamsten A, Harder MN, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Havulinna AS, Heliövaara M, Hillege H, Hofman A, Holmen O, Homuth G, Hottenga JJ, Hui J, Husemoen LL, Hysi PG, Isaacs A, Ittermann T, Jalilzadeh S, James AL, Jørgensen T, Jousilahti P, Jula A, Marie Justesen J, Justice AE, Kähönen M, Karaleftheri M, Tee Khaw K, Keinanen-Kiukaanniemi SM, Kinnunen L, Knekt PB, Koistinen HA, Kolcic I, Kooner IK, Koskinen S, Kovacs P, Kyriakou T, Laitinen T, Langenberg C, Lewin AM, Lichtner P, Lindgren CM, Lindström J, Linneberg A, Lorbeer R, Lorentzon M, Luben R, Lyssenko V, Männistö S, Manunta P, Leach IM, McArdle WL, Mcknight B, Mohlke KL, Mihailov E, Milani L, Mills R, Montasser ME, Morris AP, Müller G, Musk AW, Narisu N, Ong KK, Oostra BA, Osmond C, Palotie A, Pankow JS, Paternoster L, Penninx BW, Pichler I, Pilia MG, Polašek O, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rayner NW, Ribel-Madsen R, Rice TK, Richards M, Ridker PM, Rivadeneira F, Ryan KA, Sanna S, Sarzynski MA, Scholtens S, Scott RA, Sebert S, Southam L, Sparsø TH, Steinthorsdottir V, Stirrups K, Stolk RP, Strauch K, Stringham HM, Swertz MA, Swift AJ, Tönjes A, Tsafantakis E, van der Most PJ, Van Vliet-Ostaptchouk JV, Vandenput L, Vartiainen E, Venturini C, Verweij N, Viikari JS, Vitart V, Vohl MC, Vonk JM, Waeber G, Widén E, Willemsen G, Wilsgaard T, Winkler TW, Wright AF, Yerges-Armstrong LM, Hua Zhao J, Carola Zillikens M, Boomsma DI, Bouchard C, Chambers JC, Chasman DI, Cusi D, Gansevoort RT, Gieger C, Hansen T, Hicks AA, Hu F, Hveem K, Jarvelin MR, Kajantie E, Kooner JS, Kuh D, Kuusisto J, Laakso M, Lakka TA, Lehtimäki T, Metspalu A, Njølstad I, Ohlsson C, Oldehinkel AJ, Palmer LJ, Pedersen O, Perola M, Peters A, Psaty BM, Puolijoki H, Rauramaa R, Rudan I, Salomaa V, Schwarz PE, Shudiner AR, Smit JH, Sørensen TI, Spector TD, Stefansson K, Stumvoll M, Tremblay A, Tuomilehto J, Uitterlinden AG, Uusitupa M, Völker U, Vollenweider P, Wareham NJ, Watkins H, Wilson JF, Zeggini E, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, van Duijn CM, Fox C, Groop LC, Heid IM, Hunter DJ, Kaplan RC, McCarthy MI, North KE, O'Connell JR, Schlessinger D, Thorsteinsdottir U, Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJ. (2016). A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications, e13357, 1−11.10.1038/ncomms13357.
1.1.
2016
Walford, Geoffrey A.; Gustafsson, Stefan; Rybin, Denis; Stancakova, Alena; Chen, Han; Liu, Ching-Ti; Hong, Jaeyoung; Jensen, Richard A.; Rice, Ken; Morris, Andrew P.; Magi, Reedik; Toenjes, Anke; Prokopenko, Inga; Kleber, Marcus E.; Delgado, Graciela; Silbernagel, Guenther; Jackson, Anne U.; Appel, Emil V.; Grarup, Niels; Lewis, Joshua P. ... Florez, Jose C. (2016). Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes, 10, 3200−3211.10.2337/db16-0199.
1.1.
2016
Eicher, John D; Chami, Nathalie; Kacprowski, Tim; Nomura, Akihiro; Chen, Ming-Huei; Yanek, Lisa R; Tajuddin, Salman M; Schick, Ursula M; Slater, Andrew J; Pankratz, Nathan; Polfus, Linda; Schurmann, Claudia; Giri, Ayush; Brody, Jennifer A; Lange, Leslie A; Manichaikul, Ani; Hill, W David; Pazoki, Raha; Elliot, Paul; Evangelou, Evangelos ... Johnson, Andrew D (2016). Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals. American Journal of Human Genetics, 99 (1), 40−55.10.1016/j.ajhg.2016.05.005.
1.1.
2016
Pagani, Luca; Lawson, Daniel John; Jagoda, Evelyn; Mörseburg, Alexander; Eriksson, Anders; Mitt, Mario; Clemente, Florian; Hudjashov, Georgi; DeGiorgio, Michael; Saag, Lauri; Wall, Jeffrey D; Cardona, Alexia; Mägi, Reedik; Sayres, Melissa A Wilson; Kaewert, Sarah; Inchley, Charlotte; Scheib, Christiana L; Järve, Mari; Karmin, Monika; Jacobs, Guy S ... Metspalu, Mait (2016). Genomic analyses inform on migration events during the peopling of Eurasia. Nature, 1−5.10.1038/nature19792.
6.8.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno. (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (10), 1296−1296.10.1038/ng1016-1296c.
1.1.
2015
Zimmermann, E; Angquist, LH; Mirza, S S; Zhao, J H; Chasman, D I; Fischer, K; Qi, Q; Smith, A V; Thinggaard, M; Jarczok, M N; Nalls, M A; Trompet, S; Timpson, N J; Schmidt, B; Jackson, A U; Lyytikainen, L P; Verweij, N; Mueller-Nurasyid, M; Vikstrom, M; Marques-Vidal, P ... Sorensen, TIA. (2015). Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obesity Reviews, 16 (4), 327−340.10.1111/obr.12263.
1.1.
2015
Fall, T; Xie, W; Poon, W; Yaghootkar, H; Mägi, R; GENESIS, Consortium; Knowles, JW; Lyssenko, V; Weedon, M; Frayling, TM; Ingelsson, E. (2015). Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes. Diabetes, 64 (7), 2676−2684.10.2337/db14-1710.
1.1.
2015
Horikoshi, M; Mӓgi, R; van, de, Bunt, M; Surakka, I; Sarin, AP; Mahajan, A; Marullo, L; Thorleifsson, G; Hӓgg, S; Hottenga, JJ; Ladenvall, C; Ried, JS; Winkler, TW; Willems, SM; Pervjakova, N; Esko, T; Beekman, M; Nelson, CP; Willenborg, C; Wiltshire, S ... ENGAGE, Consortium. (2015). Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation. Plos Genetics, 11 (7), e1005230.10.1371/journal.pgen.1005230.
1.1.
2015
Surakka, I; Horikoshi, M; Mägi, R; Sarin, AP; Mahajan, A; Lagou, V; Marullo, L; Ferreira, T; Miraglio, B; Timonen, S; Kettunen, J; Pirinen, M; Karjalainen, J; Thorleifsson, G; Hägg, S; Hottenga, JJ; Isaacs, A; Ladenvall, C; Beekman, M; Esko, T ... ENGAGE, Consortium. (2015). The impact of low-frequency and rare variants on lipid levels. Nature Genetics, 47 (6), 589−597.10.1038/ng.3300.
1.1.
2015
Fall, T; Hägg, S; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Sarin, AP; Benyamin, B; Ladenvall, C; Åkerlund, M; Kals, M; Esko, T; Nelson, CP; Kaakinen, M; Huikari, V; Mangino, M; Meirhaeghe, A; Kristiansson, K; Nuotio, ML; Kobl, M ... ENGAGE, Consortium. (2015). Age- and sex-specific causal effects of adiposity on cardiovascular risk factors. Diabetes, 64 (5), 1841−1852.10.2337/db14-0988.
1.1.
2015
Pers, TH.; Karjalainen, JM.; Chan, Y.; Westra, HJ.; Wood, AR.; Yang, J.; , Lui, JC.; Vedantam, S.; Gustafsson, S.; Esko, T.; Frayling, T.; Speliotes, EK.; Genetic, Investigation, of, ANthropometric, Traits, (GIANT), Consortium; Boehnke, M.; Raychaudhuri, S.; Fehrmann, RS.; Hirschhorn, JN.; Franke, L. (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications, 6 (5890), 1−9.10.1038/ncomms6890.
1.1.
2015
Zhu, Z; Bakshi, A; Vinkhuyzen, AA; Hemani, G; Lee, SH; Nolte, IM; van, Vliet-Ostaptchouk, JV; Snieder, H; The, LifeLines, Cohort, Study; Esko, T; Milani, L; Mägi, R; Metspalu, A; Hill, WG; Weir, BS; Goddard, ME; Visscher, PM; Yang, J. (2015). Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits. American Journal of Human Genetics, 96 (3), 377−85.10.1016/j.ajhg.2015.01.001.
1.1.
2015
Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Locke, AE; Mägi, R; Strawbridge, RJ; Pers, TH; Fischer, K; Justice, AE; Workalemahu, T; Wu, JM; Buchkovich, ML; Heard-Costa, NL; Roman, TS; Drong, AW; Song, C; Gustafsson, S; Day, FR; Esko, T ... Mohlke, KL. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187−196.10.1038/nature14132.
1.1.
2015
Locke, AE.; Kahali, B.; Berndt, SI.; Justice, AE.; Pers, TH.; Day, FR.; Powell, C.; Vedantam, S.; Buchkovich, ML.; Yang, J.; Croteau-Chonka, DC.; Esko, T.; Fall, T.; Ferreira, T.; Gustafsson, S.; Kutalik, Z.; Luan, J.; Mägi, R.; Randall, JC.; Winkler, TW. ... Speliotes, EK. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197−206.10.1038/nature14177.
1.1.
2015
The, Coffee, and, Caffeine, Genetics, Consortium; Cornelis, MC; Byrne, EM; Esko, T; Nalls, MA; Ganna, A; Paynter, N; Monda, KL; Amin, N; Fischer, K; Renstrom, F; Ngwa, JS; Huikari, V; Cavadino, A; Nolte, IM; Teumer, A; Yu, K; Marques-Vidal, P; Rawal, R; Manichaikul, A ... Chasman, DI. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647−656.10.1038/mp.2014.107.
1.1.
2015
Hägg, S; Ganna, A; Van, Der, Laan, SW; Esko, T; Pers, TH; Locke, AE; Berndt, SI; Justice, AE; Kahali, B; Siemelink, MA; Pasterkamp, G; GIANT, Consortium; Strachan, DP; Speliotes, EK; North, KE; Loos, RJ; Hirschhorn, JN; Pawitan, Y; Ingelsson, E. (2015). Gene-based meta-analysis of genome-wide association studies implicates new loci involved in obesity. Human Molecular Genetics, 24 (23), 6849−6860.10.1093/hmg/ddv379.
1.1.
2015
Lunetta, KL; Day, FR; Sulem, P; Ruth, KS; Tung, JY; Hinds, DA; Esko, T; Elks, CE; Altmaier, E; He, C; Huffman, JE; Mihailov, E; Porcu, E; Robino, A; Rose, LM; Schick, UM; Stolk, L; Teumer, A; Thompson, DJ; Traglia, M ... Perry, JR. (2015). Rare coding variants and X-linked loci associated with age at menarche. Nature Communications, 6 (7756), 1−7.10.1038/ncomms8756.
1.1.
2015
Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F.; Chu, Su; Czajkowski, Jacek; Esko, Tonu; Fall, Tove; Kilpelainen, Tuomas O.; Lu, Yingchang; Magi, Reedik; Mihailov, Evelin; Pers, Tune H.; Rueeger, Sina; Teumer, Alexander; Ehret, Georg B.; Ferreira, Teresa; Heard-Costa, Nancy L.; Karjalainen, Juha ... Loos, Ruth J. F. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. Plos Genetics, 11 (10), ARTN e1005378.10.1371/journal.pgen.1005378.
1.1.
2015
Wain, LV; Shrine, N; Miller, S; Jackson, VE; Ntalla, I; Artigas, MS; Billington, CK; Kheirallah, AK; Allen, R; Cook, JP; Probert, K; Obeidat, M; Bosse, Y; Hao, K; Postma, DS; Pare, PD; Ramasamy, A; Magi, R; Mihailov, E; Reinmaa, E Melen, E ... Hall, IP (2015). Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank. The Lancet Respiratory Medicine, 3 (10), 769−781.10.1016/S2213-2600(15)00283-0.
1.1.
2015
Joshi, PK; Esko, T; Mattsson, H; Eklund, N; Gandin, I; Nutile, T; Jackson, AU; Schurmann, C; Smith, AV; Zhang, W; Okada, Y; Stančáková, A; Faul, JD; Zhao, W; Bartz, TM; Concas, MP; Franceschini, N; Enroth, S; Vitart, V; Trompet, S ... Wilson, JF. (2015). Evidence for directional dominance on complex traits relating to size and cognition in a wide range of human populations. Nature, 46 (11), 1173−1186.10.1038/nature14618.
1.1.
2015
Huffman, JE; Albrecht, E; Teumer, A; Mangino, M; Kapur, K; Johnson, T; Kutalik, Z; Pirastu, N; Pistis, G; Lopez, LM; Haller, T; Salo, P; Goel, A; Li, M; Tanaka, T; Dehghan, A; Ruggiero, D; Malerba, G; Smith, AV; Nolte, IM ... Vitart, V. (2015). Modulation of genetic associations with serum urate levels by body-mass-index in humans. PLoS ONE, 3, e0119752−e0119752.10.1371/journal.pone.0119752.
1.1.
2015
Gaulton, Kyle J; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E; Mahajan, Anubha; Locke, Adam; Rayner, N William; Robertson, Neil; Scott, Robert A; Prokopenko, Inga; Scott, Laura J; Green, Todd; Sparso, Thomas; Thuillier, Dorothee; Yengo, Loic; Grallert, Harald; Wahl, Simone; Frånberg, Mattias ... , (2015). Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nature Genetics, 47 (12), 1415−1425.10.1038/ng.3437.
1.1.
2015
Haller, Toomas; Kals, Mart; Esko, Tõnu; Mägi, Reedik; Fischer, Krista (2015). RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations. Briefings in bioinformatics, 16 (1), 39−44.10.1093/bib/bbt066.
1.1.
2015
Leitsalu, Liis; Haller, Toomas; Esko, Tõnu; Tammesoo, Mari-Liis; Alavere, Helene; Snieder, Harold; Perola, Markus; Ng, Pauline C; Mägi, Reedik; Milani, Lili; Fischer, Krista; Metspalu, Andres (2015). Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu. International Journal of Epidemiology, 44 (4), 1137−1147.10.1093/ije/dyt268.
1.1.
2015
Hägg, S; Fall, T; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Kals, M; de Vries, PS; Dehghan, A; Willems, SM; Sarin, AP; Kristiansson, K; Nuotio, ML; Havulinna, AS; de Bruijn, RF; Ikram, MA; Kuningas, M; Stricker, BH; Franco, OH; Benyamin, B ... European, Network, for, Genetic, and, Genomic, Epidemiology, (ENGAGE) consortium. (2015). Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. International Journal of Epidemiology, 44 (2), 578−586.10.1093/ije/dyv094.
1.1.
2015
Day, Felix R; Ruth, Katherine S; Thompson, Deborah J; Lunetta, Kathryn L; Pervjakova, Natalia; Chasman, Daniel I; Stolk, Lisette; Finucane, Hilary K; Sulem, Patrick; Bulik-Sullivan, Brendan; Esko, Tõnu; Johnson, Andrew D; Elks, Cathy E; Franceschini, Nora; He, Chunyan; Altmaier, Elisabeth; Brody, Jennifer A; Franke, Lude L; Huffman, Jennifer E; Keller, Margaux F ... Murray, Anna (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47 (11), 1294−303.10.1038/ng.3412.
1.1.
2015
Männik, Katrin; Mägi, Reedik; Macé, Aurélien; Cole, Ben; Guyatt, Anna L; Shihab, Hashem A; Maillard, Anne M; Alavere, Helene; Kolk, Anneli; Reigo, Anu; Mihailov, Evelin; Leitsalu, Liis; Ferreira, Anne-Maud; Nõukas, Margit; Teumer, Alexander; Salvi, Erika; Cusi, Daniele; McGue, Matt; Iacono, William G; Gaunt, Tom R ... Reymond, Alexandre (2015). Copy Number Variations and Cognitive Phenotypes in Unselected Populations. JAMA : the journal of the American Medical Association, 313 (20), 2044−2054.10.1001/jama.2015.4845.
1.1.
2015
Karmin, Monika; Saag, Lauri; Vicente, Mário; Wilson Sayres, Melissa A; Järve, Mari; Talas, Ulvi Gerst; Rootsi, Siiri; Ilumäe, Anne-Mai; Mägi, Reedik; Mitt, Mario; Pagani, Luca; Puurand, Tarmo; Faltyskova, Zuzana; Clemente, Florian; Cardona, Alexia; Metspalu, Ene; Sahakyan, Hovhannes; Yunusbayev, Bayazit; Hudjashov, Georgi; DeGiorgio, Michael ... Kivisild, Toomas (2015). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Genome Research, 25 (4), 459−466.10.1101/gr.186684.114.
5.1.
2015
Kaakinen, M.; Maegi, R.; Fischer, K.; Jarvelin, M. -R.; Morris, A. P.; Prokopenko, I. (2015). A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants. Human Heredity, 79: 43rd European Mathematical Genetics Meeting (EMGM), Brest, FRANCE, APR 16-17, 2015. Karger, 39−39. (1).
1.1.
2014
Walsh, KM; Codd, V; Smirnov, IV; Rice, T; Decker, PA; Hansen, HM; Kollmeyer, T; Kosel, ML; Molinaro, AM; McCoy, LS; Bracci, PM; Cabriga, BS; Pekmezci, M; Zheng, S; Wiemels, JL; Pico, AR; Tihan, T; Berger, MS; Chang, SM; Prados, MD ... Wrensch, MR. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46 (7), 731−735.10.1038/ng.3004.
1.1.
2014
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y14; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J ... Frayling, TM. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173−1186.10.1038/ng.3097.
1.1.
2014
Clemente, FJ.; Cardona, A.; Inchley, CE.; Peter, BM.; Jacobs, G.; Pagani, L.; Lawson, DJ.; Antao, T.; Vicente, M.; Mitt, M.; DeGiorgio, M.; Faltyskova, Z.; Xue, YL.; Ayub, Q.; Szpak, M.; Magi, R.; Eriksson, A.; Manica, A.; Raghavan, M.; Rasmussen, M. ... Kivisild, T. (2014). A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. American Journal of Human Genetics, 95 (5), 584−589.10.1016/j.ajhg.2014.09.016.
1.1.
2014
Dimas, AS; Lagou, V; Barker, A; Knowles, JW; Magi, R; Hivert, MF; Benazzo, A; Rybin, D; Jackson, AU; Stringham, HM; Song, C; Fischer-Rosinsky, A; Boesgaard, TW; Grarup, N; Abbasi, FA; Assimes, TL; Hao, K; Yang, X Lecoeur, C; Barroso, I; Bonnycastle, LL ... MAGIC, Investigators. (2014). Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity. Diabetes, 63 (6), 2158−2171.10.2337/db13-0949.
1.1.
2014
Perry, J.R.B.; Day, F.; Elks, C.E.; Sulem, P.; Thompson, D.J.; Ferreira, T.; He, C.; Chasman, D.I.; Esko, T.; Thorleifsson, G.; Albrecht, E.; Ang, W.Q.; Corre, T.; Cousminer, D.L.; Feenstra, B.; Franceschini, N.; Ganna, A.; Johnson, A.D.; Kjellqvist, S.; Lunetta, K.L. ... Ong, K.K. (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92.10.1038/nature13545.
1.1.
2014
Hoggart, CJ; Venturini, G; Mangino, M; Gomez, F; Ascari, G; Zhao, JH; Teumer, A; Winkler, TW; Tsernikova, N; Luan, J; Mihailov, E; Ehret, GB; Zhang, W; Lamparter, D; Esko, T; Mace, A; Rueger, S; Bochud, P-Y; Barcella, M; Dauvilliers, Y ... Kutalik, Z. (2014). Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. Plos Genetics, 10 (7), e1004508.10.1371/journal.pgen.1004508.
1.1.
2014
Metsalu, Tauno; Viltrop, Triin; Tiirats, Airi; Rajashekar, Balaji; Reimann, Ene; Kõks, Sulev; Rull, Kristiina; Milani, Lili; Acharya, Ganesh; Basnet, Purusotam; Vilo, Jaak; Mägi, Reedik; Metspalu, Andres; Peters, Maire; Haller-Kikkatalo, Kadri; Salumets, Andres (2014). Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. Epigenetics, 9 (10), 1397−1409.10.4161/15592294.2014.970052.
1.1.
2014
Lim, ET.; Würtz, Peter; Havulinna, AS.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, RM.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina ... SISu, Project (2014). Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. PLOS Genetics, 10 (7), e1004494.10.1371/journal.pgen.1004494.
1.1.
2014
Mägi, Reedik; Metspalu, Andres; Mihailov, Evelin (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234−244.10.1038/ng.2897.
1.1.
2014
Schramm, Katharina; Marzi, Carola; Schurmann, Claudia; Carstensen, Maren; Reinmaa, Eva; Biffar, Reiner; Eckstein, Gertrud; Gieger, Christian; Grabe, Hans-Jorgen; Homuth, Georg; Kastenmuller, Gabriele; Magi, Reedik; Metspalu, Andres; Mihailov, Evelin; Peters, Annette; Petersmann, Astrid; Roden, Michael; Strauch, Konstantin; Suhre, Karsten; Teumer, Alexander ... Prokisch, Holger (2014). Mapping the genetic architecture of gene regulation in whole blood. PLoS ONE, 9 (4), e93844−e93844.10.1371/journal.pone.0093844.
1.1.
2014
Winkler, T.W.; Day, FR.; Croteau-Chonka, DC.; Wood, AR.; Locke, AE.; Magi, R.; Ferreira, T.; Fall, T.; Graff, M.; Justice, AE.; Luan, JA.; Gustafsson, S.; Randall, JC.; Vedantam, S.; Workalemahu, T.; Kilpelainen, TO.; Scherag, A.; Esko, T.; Kutalik, Z.; Heid, IM. ... Loos, RJF (2014). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5), 1192−1212.10.1038/nprot.2014.071.
1.1.
2014
Prokopenko, Inga; Poon, Wenny; Magi, Reedik; Prasad B, Rashmi; Salehi, S Albert; Almgren, Peter; Osmark, Peter; Bouatia-Naji, Nabila; Wierup, Nils; Fall, Tove; Stancakova, Alena; Barker, Adam; Lagou, Vasiliki; Osmond, Clive; Xie, Weijia; Lahti, Jari; Jackson, Anne U; Cheng, Yu-Ching; Liu, Jie; O'Connell, Jeffrey R ... Lyssenko, Valeriya (2014). A central role for GRB10 in regulation of islet function in man. Plos Genetics, 10 (4), e1004235−e1004235.10.1371/journal.pgen.1004235.
1.1.
2014
Lokk, Kaie; Modhukur, Vijayachitra; Rajashekar, Balaji; Märtens, Kaspar; Mägi, Reedik; Kolde, Raivo; Koltšina, Marina; Nilsson, Torbjörn K.; Vilo, Jaak; Salumets, Andres; Tõnisson, Neeme (2014). DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biology, 15 (4), R54.10.1186/gb-2014-15-4-r54.
1.1.
2014
Fischer, K.; Kettunen, J.; Würtz, P.; Haller, T.; Aki S. Havulinna, A.S.; Kangas, A.J.; Soininen, P.; Esko, T.; Tammesoo, M-L.; Mägi, R.; Smit, S.; Palotie, A.; SRipatti, S.; Veikko Salmaa, V.; Ala-Korpela, M.; Perola, M.; Metspalu, A. (2014). Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons. PLOS Medicine, 11 (2), e1001606.10.1371/journal.pmed.1001606.
1.1.
2014
Raghavan, M.; Skoglund, P.; Graf, K.E.; Metspalu, M.; Albrechtsen, A.; Moltke, I.; Rasmussen, S.; Stafford, T.W. Jr.; Orlando, L.; Metspalu, E.; Karmin, M.; Tambets, K.; Rootsi, S.; Mägi, R.; Campos, P.F., Balanovska, E., Balanovsky, O., Khusnutdinova, E., Litvinov, S.; Osipova, L.P.; Fedorova, S.A.; Voevoda, M.I.; DeGiorgio, M.; Sicheritz-Ponten, T. ... Willerslev, E. (2014). Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature, 505 (7481), 87−91.10.1038/nature12736.
5.1.
2014
Morris, A. P.; Teslovich, T. M.; Ferreira, T.; Mahajan, A.; Lee, Y.; Rayner, N. W.); Magi, R. (2014). Fine-mapping type 2 diabetes susceptibility loci with high-density imputation. DIABETOLOGIA, 57: 50th EASD Annual Meeting, Vienna, Austria, 15-19.09.2014. Springer, S50−S51.
1.1.
2013
Mägi, R.; Manning, S.; Yousseif, A.; Pucci, A.; Santini, F.; Karra, E.; Querci, G.; Pelosini, C.; McCarthy, M.I.; Lindgren, C.M.; Batterham, R.L. (2013). Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery. PLoS ONE, 8 (8), e70735.10.1371/journal.pone.0070735.
1.1.
2013
Evans, DM; Brion, MJ; Paternoster, L; Kemp, JP; McMahon, G; Munafò, M; Whitfield, JB; Medland, SE; Montgomery, GW; GIANT, Consortium; CRP, Consortium; TAG, Consortium; Timpson, NJ; St Pourcain, B; Lawlor, DA; Martin, NG; Dehghan, A; Hirschhorn, J; Davey, Smith, G. (2013). Mining the human phenome using allelic scores that index biological intermediates. Plos Genetics, 9 (10), e1003919−e1003919.10.1371/journal.pgen.1003919.
1.1.
2013
Vimaleswaran, KS.; Berry, DJ.; Lu, C.; Tikkanen, E.; Pilz, S.; Hiraki, LT.; Cooper, JD.; Dastani, Z.; Li, R.; Houston, DK.; Wood, AR.; Michaëlsson, K.; Vandenput, L.; Zgaga, L.; Yerges-Armstrong, LM.; McCarthy, MI.; Dupuis, J.; Kaakinen, M.; Kleber, ME.; Jameson, K. ... Hyppönen, E. (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLOS Medicine, 10 (2), e1001383.10.1371/journal.pmed.1001383.
1.1.
2013
Paul, Dirk S.; Albers, Cornelis A.; Rendon, Augusto; Voss, Katrin; Stephens, Jonathan; HaemGen, Consortium; van der Harst, Pim; Chambers, John C.; Soranzo, Nicole; Ouwehand, Willem H.; Deloukas, Panos (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Research, 23 (7), 1130−1141.10.1101/gr.155127.113.
1.1.
2013
Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpeläinen, TO; Esko, T; Mägi, R; Li, S; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A ... Heid, IM (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. Plos Genetics, 9 (6), e1003500.10.1371/journal.pgen.1003500.
1.1.
2013
Thorgeirsson, TE; Gudbjartsson, DF; Sulem, P; Besenbacher, S; Styrkarsdottir, U; Thorleifsson, G; Walters, GB; TAG, Consortium; Oxford-GSK, Consortium; ENGAGE, consortium; Furberg, H; Sullivan, PF; Marchini, J; McCarthy, MI; Steinthorsdottir, V; Thorsteinsdottir, U; Stefansson, K. (2013). A common biological basis of obesity and nicotine addiction. Translational Psychiatry, 3, 1−7.10.1038/tp.2013.81.
1.1.
2013
Tammiste, Anu; Jiang, Tao; Fischer, Krista; Mägi, Reedik; Krjutškov, Kaarel; Pettai, Kristi; Esko, Tõnu; Li, Yingrui; Tansey, Katherine E; Carroll, Liam S; Uher, Rudolf; McGuffin, Peter; Võsa, Urmo; Tšernikova, Natalia; Saria, Alois; Ng, Pauline C; Eller, Triin; Vasar, Veiko; Nutt, David J; Maron, Eduard ... Metspalu, Andres (2013). Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression. Journal of Psychopharmacology, 27 (10), 915−920.10.1177/0269881113499829.
1.1.
2013
Fall, T.; Hagg, S.; Magi, R.; Ploner, A.; Fischer, K.; Horikoshi, M.; Sarin, AP.; Thorleifsson, G.; Ladenvall, C.; Kals, M.; Kuningas, M.; Draisma, HHM.; Ried, JS.; van Zuydam, NR.; Huikari, V.; Mangino, M.; Sonestedt, E.; Benyamin, B.; Nelson, CP.; Rivera, NV. ... Prokopenko, I. (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLOS Medicine, 10 (6), e1001474−e1001474.10.1371/journal.pmed.1001474.
1.1.
2013
Migliano, A.; Romero, I.; Metspalu, M.; Leavesley, M.; Pagani, L.; Antao, T.; Huang, D.; Sherman, B.; Siddle, K.; Scoles, C.; Hudjashov, G.; Kaitokai, E.; Mandui, H.; Babalu, A.; Belatti, M.; Cagan, A.; Hopkinshow, B.; Show, C.; Tabbada, K.; Nelis, M. ... Kivisild, T. (2013). Evolution of the pygmy phenotype: evidence of positive selection from genome-wide scans in African, Asian and Melanesian pygmies. Human Biology, 85, 251−284.
1.1.
2013
Nikopensius, T; Annilo, T; Jagomägi, T; Gilissen, C; Kals, M; Krjutškov, K; Mägi, R; Eelmets, M; Gerst-Talas, U; Remm, M; Saag, M; Hoischen, A; Metspalu, A (2013). Non-syndromic Tooth Agenesis Associated with a Nonsense Mutation in Ectodysplasin-A (EDA). Journal of Dental Research, 92 (6), 507−511.10.1177/0022034513487210.
1.1.
2013
Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69.10.1038/ng.2606.
1.1.
2013
Codd, V; Nelson, CP; Albrecht, E; Mangino, M; Deelen, J; Buxton, JL; Hottenga, JJ; Fischer, K; Esko, T; Surakka, I; Broer, L; Nyholt, DR; Leach, IM; Salo, P; Hägg, S; Matthews, MK; Palmen, J; Norata, GD; O'Reilly, PF; Saleheen, D ... Samani, NJ (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45 (4), 422−427.10.1038/ng.2528.
1.1.
2013
Hu, YJ; Berndt, SI; Gustafsson, S; Ganna, A; Genetic Investigation of ANthropometric Traits (GIANT), Consortium; Hirschhorn, J; North, KE; Ingelsson, E; Lin, DY (2013). Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. American Journal of Human Genetics, 93 (2), 236−248.10.1016/j.ajhg.2013.06.011.
1.1.
2013
Parsa, A; Fuchsberger, C; Köttgen, A; O'Seaghdha, CM; Pattaro, C; de Andrade, M; Chasman, DI; Teumer, A; Endlich, K; Olden, M; Chen, MH; Tin, A; Kim, YJ; Taliun, D; Li, M; Feitosa, M; Gorski, M; Yang, Q; Hundertmark, C; Foster, MC ... Böger, CA. (2013). Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function. Journal of the American Society of Nephrology, 24 (12), 2105−2117.10.1681/ASN.2012100983.
5.1.
2013
Lagou, V.; Mägi, R.; Surakka, I. ; Sarin, A. -P.; Horikoshi, M.; Thorleifsson, G. ; Hagg, S.; Beekman, M.; Ladenvall, C.; Hottenga, J. -J.; Ried, J. S.; McCarthy, M. I.Morris, A.; Ripatti, S.; Prokopenko, I. (2013). Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S60.
5.1.
2013
Horikoshi, M.; Mägi, R.; Surakka, I.; Sarin, A. -P.; Mahajan, A.; Marullo, L.; Ferreira, T. ; Esko, T.; Lindgren, C. M.; Morris, A. P.; McCarthy, M. I.; Ripatti, S.; Prokopenko, I; ENGAGE, Consortium. (2013). Large-scale genome-wide association meta-analysis of the 1000 genomes project imputed data identifies novel susceptibility loci for glycaemic and obesity traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S61.
5.1.
2013
Horikoshi, Momoko; Magi, Reedik; Surakka, Ida; Sarin, Antti-Pekka; Mahajan, Anubha; Marullo, Letizia; Ferreira, Teresa; Esko, Tonu; Morris, Andrew P.; Mccarthy, Mark I.; Ripatti, Samuli; Prokopenko, Inga (2013). Large-Scale Genome-Wide Association Meta-Analysis using Imputation from the Dense 1000 Genomes Project Map Identifies Novel Susceptibility Loci for Glycemic and Obesity Traits. Diabetes, A83−A83.
5.2.
2013
Žilina, Olga; Mägi, Reedik; Kurg, Ants; Õunap, Katrin (2013). https://www.eshg.org/fileadmin/www.eshg.org/conferences/2013/ESHG2013AbstractsWebsite.pdf. European Journal of Human Genetics, 21: European Human Genetics Conference 2013, Paris France, June 8-11, 2013. Ed. G-J B van Ommen. Nature Publishing Group, 183−183. (2).
5.2.
2013
Tõnisson, N.; Lokk, K; Modhukur, V.; Rajashekar, B; Martens, K; Koltšina, M; Mägi, R.; Kolde, R.; Salumets, A. (2013). DNA metylome comparison of various human tissues. European Journal of Human Genetics: European Human Genetics Conference; Pariis, Prantsusmaa; 8.–11. juuni, 2013. Nature Publishing Group, 373−373. (21; Suppl 2).
1.1.
2012
Chasman, DI.; Fuchsberger, C.; Pattaro, C.; Teumer, A.; Boger, CA.; Endlich, K.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Kottgen, A. (2012). Integration of Genome-Wide Association Studies with Biological Knowledge Identifies Six Novel Genes Related to Kidney Function. Human Molecular Genetics, 21 (24), 5329−5343.10.1093/hmg/dds369.
1.1.
2012
Nürnberg, ST.; Rendon, A.; Smethurst, PA.; Paul, DS.; Voss, K.; Thon, JN.; Lloyd-Jones, H.; Sambrook, JG.; Tijssen, MR.; Gieger, C.; Radhakrishnan, A.; Cvejic, A.; Tang, W.; Porcu, E.; Pistis, G.; Serbanovic-Canic, J.; Elling, U.; Goodall, AH.; Labrune, Y.; Lopez, LM. ... Ouwehand, W. (2012). A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood, 120 (24), 4859−4868.10.1182/blood-2012-01-401893.
1.1.
2012
Mägi, R; Asimit, JL; Day-Williams, AG; Zeggini, E; Morris, AP. (2012). Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases. Genetic Epidemiology, 36 (8), 785−796.10.1002/gepi.21675.
1.1.
2012
Okada, Y; Sim, X; Go, MJ; Wu, JY; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, SC; Wong, TY; Liu, J; Young, TL; Aung, T; Seielstad, M; Teo, YY; Kim, YJ; Lee, JY; Han, BG ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904−909.10.1038/ng.2352.
1.1.
2012
Yang, J; Loos, RJ; Powell, JE; Medland, SE; Speliotes, EK; Chasman, DI; Rose, LM; Thorleifsson, G; Steinthorsdottir, V; Mägi, R; Waite, L; Vernon, Smith, A; Yerges-Armstrong, LM; Monda, KL; Hadley, D; Mahajan, A; Li, G; Kapur, K; Vitart, V; Huffman, JE ... Visscher, PM (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature, 490 (7419), 267−272.DOI:10.1038/nature11401.
1.1.
2012
Scott, RA.; Lagou, V.; Welch, RP.; Wheeler, E.; Montasser, ME.; Luan, J.; Mägi, R.; Strawbridge, RJ.; Rehnberg, E.; Gustafsson, S.; Kanoni, S.; Rasmussen-Torvik, LJ.; Yengo, L.; Lecoeur, C.; Shungin, D.; Sanna, S.; Sidore, C.; Johnson, PC.; Jukema, JW.; Johnson, T. ... Barroso, I. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991−1005.10.1038/ng.2385.
1.1.
2012
Fox, Caroline S; Liu, Yongmei; White, Charles C; Feitosa, Mary; Smith, Albert V; Heard-Costa, Nancy; Lohman, Kurt; Johnson, Andrew D; Foster, Meredith C; Greenawalt, Danielle M; Griffin, Paula; Ding, Jinghong; Newman, Anne B; Tylavsky, Fran; Miljkovic, Iva; Kritchevsky, Stephen B; Launer, Lenore; Garcia, Melissa; Eiriksdottir, Gudny; Carr, J Jeffrey ... GLGC, Consortium. (2012). Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. Plos Genetics, 8 (5), e1002695−e1002695.10.1371/journal.pgen.1002695.
1.1.
2012
Verhoeven, Virginie J M; Hysi, Pirro G; Saw, Seang-Mei; Vitart, Veronique; Mirshahi, Alireza; Guggenheim, Jeremy A; Cotch, Mary Frances; Yamashiro, Kenji; Baird, Paul N; Mackey, David A; Wojciechowski, Robert; Ikram, M Kamran; Hewitt, Alex W; Duggal, Priya; Janmahasatian, Sarayut; Khor, Chiea-Chuen; Fan, Qiao; Zhou, Xin; Young, Terri L; Tai, E-Shyong ... Klaver, Caroline C W. (2012). Large scale international replication and meta-analysis study confirms association of the 15q14 locus with myopia. The CREAM consortium. Human Genetics, 131 (9), 1467−1480.10.1007/s00439-012-1176-0.
1.1.
2012
Ellis, JW.; Chen, MH.; Foster, MC.; Liu, CT.; Larson, MG.; de Boer, I.; Kottgen, A.; Parsa, A.; Bochud, M.; Boger, CA.; Kao, L.; Fox, CS.; O'Seaghdha, CM; CKDGen, Consortium ; CARe Renal, Consortium. (2012). Validated SNPs for eGFR and their associations with albuminuria. Human Molecular Genetics, 21 (14), 3293−3298.10.1093/hmg/dds138.
1.1.
2012
Parts, L.; Hedman, AK.; Keildson, S.; Knights, AJ.; Abreu-Goodger, C.; van de Bunt, M.; Guerra-Assuncao, JA.; Bartonicek, N.; van Dongen, S.; Mägi, R.; Nisbet, J.; Barrett, A.; Rantalainen, M.; Nica, AC.; Quail, MA.; Small, KS.; Glass, D.; Enright, AJ.; Winn, J.; Deloukas, P. ... Lindgren, CM. (2012). Extent, Causes, and Consequences of Small RNA Expression Variation in Human Adipose Tissue. Plos Genetics, 8 (5), e1002704−e1002704.10.1371/journal.pgen.1002704.
1.1.
2012
Taal, HR.; St Pourcain, B.; Thiering, E.; Das, S.; Mook-Kanamori, DO.; Warrington, NM.; Kaakinen, M.; Kreiner-Moller, E.; Bradfield, JP.; Freathy, RM.; Geller, F.; Guxens, M.; Cousminer, DL.; Kerkhof, M.; Timpson, NJ.; Ikram, MA.; Beilin, LJ.; Bonnelykke, K.; Buxton, JL.; Charoen, P. ... DeCarli, C. (2012). Common variants at 12q15 and 12q24 are associated with infant head circumference. Nature Genetics, 44 (5), 532−538.10.1038/ng.2238.
1.1.
2012
Ikram, MA.; Fornage, M.; Smith, AV.; Seshadri, S.; Schmidt, R.; Debette, S.; Vrooman, HA.; Sigurdsson, S.; Ropele, S.; Taal, HR.; Mook-Kanamori, DO.; Coker, LH.; Longstreth, WT.; Niessen, WJ.; DeStefano, AL.; Beiser, A.; Zijdenbos, AP.; Struchalin, M.; Jack, CR.; Rivadeneira, F. ... Wilson, JF. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5), 539−544.10.1038/ng.2245.
1.1.
2012
Manning, AK.; Hivert, MF.; Scott, RA.; Grimsby, JL.; Bouatia-Naji, N.; Chen, H.; Rybin, D.; Liu, CT.; Bielak, LF.; Prokopenko, I.; Amin, N.; Barnes, D.; Cadby, G.; Hottenga, JJ.; Ingelsson, E.; Jackson, AU.; Johnson, T.; Kanoni, S.; Ladenvall, C.; Lagou, V. ... Langenberg, C. (2012). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44 (6), 659−669.10.1038/ng.2274.
1.1.
2012
Bradfield, JP.; Taal, HR.; Timpson, NJ.; Scherag, A.; Lecoeur, C.; Warrington, NM.; Hypponen, E.; Holst, C.; Valcarcel, B.; Thiering, E.; Salem, RM.; Schumacher, FR.; Cousminer, DL.; Sleiman, PMA.; Zhao, JH.; Berkowitz, RI.; Vimaleswaran, KS.; Jarick, I.; Pennell, CE.; Evans, DM. ... Grant, SFA. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44 (5), 526−531.10.1038/ng.2247.
1.1.
2012
Pattaro, C.; Köttgen, A.; Teumer, A.; Garnaas, M.; Boger, CA.; Fuchsberger, C.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Fox, CS. (2012). Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function. Plos Genetics, 8 (3), e1002584−e1002584.10.1371/journal.pgen.1002584.
1.1.
2012
Yang, J; Ferreira, T; Morris, AP; Medland, SE; GIANT, consortium; DIAGRAM, consortium; Madden, PAF; Heath, AC; Martin, NG; Montgomery, GW; Weedon, MN; Loos, RJ; Frayling, TM; McCarthy, MI; Hirschhorn, JN; Goddard, ME; Visscher, PM. (2012). Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits. Nature Genetics, 44, 369−375.
1.1.
2012
Dastani, Z; Hivert, M-F; Timpson, N; Perry, JRB; Yuan, X; Scott, RA; Henneman, P; Heid, IM; Kizer, JR; Lyytikäinen, L-P; et, al. (2012). Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals. Plos Genetics, 8 (3), e1002607−e1002607.
1.1.
2012
Min, Josine L.; Nicholson, George; Halgrimsdottir, Ingileif; Almstrup, Kristian; Petri, Andreas; Barrett, Amy; Travers, Mary; Rayner, Nigel W.; Mägi, Reedik; Pettersson, Fredrik H.; Broxholme, John; Neville, Matt J.; Wills, Quin F.; Cheeseman, Jane; The GIANT, Consortium; The MolPAGE, Consortium; Allen, Maxine; Holmes, Chris C.; Spector, Tim D.; Fleckner, Jan ... Zondervan, Krina T. (2012). Coexpression Network Analysis in Abdominal and Gluteal Adipose Tissue Reveals Regulatory Genetic Loci for Metabolic Syndrome and Related Phenotypes. Plos Genetics, 8 (2), e1002505−e1002505.
1.1.
2012
Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N ... Sladek, Robert (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLoS ONE, 7 (1), e29202−e29202.
5.1.
2012
Mägi, R; Morris, AP. (2012). Genome-wide association analysis of rare variants identifies potential novel susceptibility genes for type 1 diabetes and coronary artery disease. ANNALS OF HUMAN GENETICS, 76: European Mathematical Genetics Meeting, Gottingen, GERMANY, APR 12-13, 2012. Wiley-Blackwell, 421−422.
5.1.
2012
Mägi, R; Horikoshi, M; Surakka, I; Wiltshire, S; Sarin, AP; Mahajan, A; Marullo, L; Ferreira, T; Hagg, S; Ried, JS; Winkler, T; Thorleifsson, G; Tsernikova, N; Esko, T; Willenborg, C; Nelson, CP; Beekman, M; Willems, SM; McCarthy, MI; Morris, AP ... Prokopenko, I. (2012). Large-scale Genome-wide Association Meta-analysis Using Imputation from 2188-haplotype 1000 Genomes Reference Panel Identifies Novel Susceptibility Loci for Anthropometric and Glycemic Traits. GENETIC EPIDEMIOLOGY, 36: Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Stevenson, WA, OCT 18-20, 2012. Wiley-Blackwell, 776−777. (7).
5.1.
2012
Dimas, A.S.; Gomes, V.I.; Knowles, J.; Mägi, R.; Barker, A.; Hivert, M.-F.; Benazzo, A.; Rybin, D.; Assimes, T.I.; Ouertermous, T.; Walker, M.; Florez, J.C.; Barroso, I.; Langenberg, Cl.; Dupuis, J.; Watanabe, R.; McCarthy, M.; Ingelsson, E.; Prokopenko, I. (2012). Impact of Type 2 Diabetes Susceptibility Loci on Variation in Physiologic Glycaemic Traits in Non-Diabetic Individuals. Circulation, 126: AHA Scientific Session 2012, Los Angeles, USa, 3-7. Nov.. Lippincott Williams & Wilkins, 14977. (21).
1.1.
2011
Bailey-Wilson, JE.; Brennan, JS.; Bull, SB.; Culverhouse, R.; Kim, Y.; Jiang, Y.; Jung, JS.; Li, Q.; Lamina, C.; Liu, Y.; Magi, R.; Niu, YS.; Simpson, CL.; Wang, LB.; Yilmaz, YE.; Zhang, HP.; Zhang, ZG. (2011). Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data. Genetic Epidemiology, 35, S92−S100.
1.1.
2011
Chambers, JC; Zhang, WH; Sehmi, J; Li, XZ; Wass, MN; Van der Harst, P; Holm, H; Sanna, S; Kavousi, M; Baumeister, SE; Coin, LJ; Deng, GH; Gieger, C; Heard-Costa, NL; et, al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43 (11), 1131−1138.10.1038/ng.970.
1.1.
2011
Gieger, C; Radhakrishnan, A; Cvejic, A; Tang, WH; Porcu, E; Pistis, G; Serbanovic-Canic, J; Elling, U; Goodall, AH; Labrune, Y; Lopez, LM; Magi, R; Meacham, S; Okada, Y; Pirastu, N; Sorice, R; Teumer, A; Voss, K; Zhang, WH; Ramirez-Solis, R ... Soranzo, N (2011). New gene functions in megakaryopoiesis and platelet formation. Nature, 480 (7376), 201−208.
1.1.
2011
Metspalu, M.; Romero, IG.; Yunusbayev, B.; Chaubey, G.; Mallick, CB.; Hudjashov, G.; Nelis, M.; Mägi, R.; Metspalu, E.; Remm, M.; Pitchappan, R.; Singh, L.; Thangaraj, K.; Villems, R.; Kivisild, T. (2011). Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia. American Journal of Human Genetics, 89 (6), 731−44.10.1016/j.ajhg.2011.11.010.
1.1.
2011
Strawbridge, RJ; Dupuis, J; Prokopenko, I; Barker, A; Ahlqvist, E; Rybin, D; Petrie, JR; Travers, ME; Bouatia-Naji, N; Dimas, AS; Nica, A; Wheeler, E; Chen, H; Voight, BF; Taneera, J; Kanoni, S; Peden, JF; Turrini, F; Gustafsson, S; Zabena, C ... Florez, JC. (2011). Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes, 60 (10), 2624−2634.10.2337/db11-0415.
1.1.
2011
Zhu, H.; Shyh-Chang, N.; Segrè, AV.; Shinoda, G.; Shah, SP.; Einhorn, WS.; Takeuchi, A.; Engreitz, JM.; Hagan, JP.; Kharas, MG.; Urbach, A.; Thornton, JE.; Triboulet, R.; Gregory, RI.; DIAGRAM, Consortium; MAGIC, Investigators; Altshuler, D.; Daley, GQ. (2011). The Lin28/let-7 axis regulates glucose metabolism. Cell, 147 (1), 81−94.
1.1.
2011
Chaubey, Gyaneshwer; Metspalu, Mait; Choi, Ying; Mägi, Reedik; Gallego Romero, Irene; Soares, Pedro; van Oven, Mannis; Behar, Doron M; Rootsi, Siiri; Hudjashov, Georgi; Basu Mallick, Chandana; Karmin, Monika; Nelis, Mari; Parik, Jüri; Goverdhana Reddy, Alla; Metspalu, Ene; vanDriem, George; Xue, Yali; Tyler-Smith, Chris; Thangaraj, Kumarasamy ... Kivisild, Toomas. (2011). Population Genetic Structure in Indian Austroasiatic speakers: The Role of Landscape Barriers and Sex-specific Admixture. Molecular Biology and Evolution, 28(2), 1013−24.
1.1.
2011
Speliotes, EK; Yerges-Armstrong, LM; Wu, J; Hernaez, R; Kim, LJ; Palmer, CD; Gudnason, V; Eiriksdottir, G; Garcia, ME; Launer, LJ; Nalls, MA; Clark, JM; Mitchell, BD; Shuldiner, AR; NASH, CRN; GIANT, Consortium; MAGIC, Investigators; GOLD, Consortium (2011). Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits. Plos Genetics, 7 (3), e1001324.10.1371/journal.pgen.1001324.
1.1.
2011
Kilpelaeinen, TO; den Hoed, M; Ong, KK; Grontved, A; Brage, S; Jameson, K; Cooper, C; Khaw, KT; Ekelund, U; Wareham, NJ; Loos, RJF; Early Growth Genetics Consortium, incl. Magi R (2011). Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 (4), 851−860.
1.1.
2011
The International Consortium for Blood Pressure Genome-Wide Association Studies, incl. Sõber, S.; Snieder, H.; Org, E.; Veldre, G.; Viigimaa, M.; Laan, M. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478 (7367), 103−109.10.1038/nature10405.
1.1.
2011
Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Johnson, A.D.; Bochud, M.; Rice, K.M.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C. ... Metspalu, A. et al (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics, 43, 1005−1011.10.1038/ng.922.
1.1.
2011
Yang, J.; Weedon, M.N.; Purcell, S.; Lettre, G.; Estrada, K.; Willer, C.J.; Smith, A.V.; Ingelsson, E.; O'Connell, J.R.; Mangino, M.; Mägi, R.; Madden, P.A.; Heath, A.C.; Nyholt, D.R.; Martin, N.G.; Montgomery, G.W.; Frayling, T.M.; Hirschhorn, J.N.; McCarthy, M.I.; Goddard, M.E. ... Visscher, P.M. (2011). Genomic inflation factors under polygenic inheritance. European Journal of Human Genetics, 19, 807−812.10.1038/ejhg.2011.39.
1.1.
2011
Sulem, P.; Gudbjartsson, D. F.; Geller, F.; Prokopenko, I.; Feenstra, B.; Aben, K.K.H.; Franke, B.; den Heijer, M.; Kovacs, P.; Stumvoll, M.; Mägi, R.; Yanek, L.R.; Becker, L.C.; Boyd, H.A.; Stacey, S.N.; Bragi Walters, G.; Jonasdottir, A.; Thorleifsson, G.; Holm, H.; Gudjonsson, S.A. ... Stefansson, K. (2011). Sequence variants at CYP1A1–CYP1A2 and AHR associate with coffee consumption. Human Molecular Genetics, 20 (10), 2071−2077.
1.1.
2011
Böger, CA; Chen, MH; Tin, A; Olden, M; Köttgen, A; de Boer, IH; Fuchsberger, C; O’Seaghdha, CM; Pattaro, C; Teumer, A; et, al. (2011). CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology, 22, 555−570.
1.1.
2011
Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
1.2.
2011
Mägi, R.; Kumar, A.; Morris, AP. (2011). Assessing the impact of missing genotype data in rare variant association analysis. BMC Proceedings, 9 (5), S107−S107.
1.1.
2010
Nettleton, JA; McKeown, NM; Kanoni, S; Lemaitre, RN; Hivert, MF; Ngwa, J; van Rooij, FJA; Sonestedt, E; Wojczynski, MK; Ye, Z; Tanaka, T; CHARGE, Whole Grain Foods Study Grp incl. Mägi, R. (2010). Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies. Diabetes Care, 33 (12), 2684−2691.
1.1.
2010
Speliotes, E.K.; Willer, C.J.; Berndt, S.I.; Monda, K.L.; Thorleifsson, G.; Jackson, A.U.; Allen, H.L.; Lindgren, C.M.; Luan, J.; Mägi, R.; Randall, J.C.; Vedantam, S.; Winkler, T.W.; Workalemahu, T.; Heid, I.M.; Qi, L.; Steinthorsdottir, V.; Weedon, M.N.; Wheeler, E.; Wood, A.R. ... Hayward, C. (2010). Genome-wide association study of 249,796 individuals reveals eighteen loci associated with body mass index. Nature Genetics, 11, 937−948.10.1038/ng.686.
1.1.
2010
Soranzo, Nicole; Sanna, Serena; Wheeler, Eleanor; Gieger, Christian; Radke, Dörte; Dupuis, Josée; Bouatia-Naji, Nabila; Langenberg, Claudia; Prokopenko, Inga; Stolerman, Elliot; Sandhu, Manjinder S; Heeney, Matthew M; Devaney, Joseph M; Reilly, Muredach P; Ricketts, Sally L; Stewart, Alexandre FR; Voight, Benjamin F; Willenborg, Christina; Wright, Benjamin; Altshuler, David ... Meigs, James B (2010). Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways. Diabetes, 59 (12), 3229−3239.10.2337/db10-0502.
1.1.
2010
Mägi, Reedik; Lindgren, Cecilia M.; Morris, Andrew P. (2010). Meta-analysis of sex-specific genome-wide association studies. Genetic Epidemiology, 34 (8), 846−853.10.1002/gepi.20540.
1.1.
2010
Lango Allen, Hana; Estrada, Karol; Lettre, Guillaume; Berndt, Sonja I; Weedon, Michael N; Rivadeneira, Fernando; Willer, Cristen J; Jackson, Anne U; Vedantam, Sailaja; Raychaudhuri, Soumya; Ferreira, Teresa; Wood, Andrew R; Weyant, Robert J; Segre, Ayellet V; Speliotes, Elizabeth K; Wheeler, Eleanor; Soranzo, Nicole; Park, Ju-Hyun; Yang, Jian; Gudbjartsson, Daniel ... Hirschhorn, Joel N (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467 (7317), 832−838.
1.1.
2010
Oitmaa, E.; Peters, M.; Vaidla, K.; Andreson, R.; Mägi, R.; Slavin, G.; Velthut, .; Tõnisson, N.; Reimand, T.; Remm, M.; Schneider, M.; Õunap, K.; Salumets, A.; Metspalu, A. (2010). Molecular diagnosis of Down Syndrome using Quantitative APEX-2 microarrays. Prenatal Diagnosis, 30, 1170−1177.
1.1.
2010
Dupuis, J.; Langenberg, C.; Prokopenko, I.; Saxena, R.; Soranzo, N.; Jackson, A.U.; Wheeler, E.; Glazer, N.L.; Bouatia-Naji, N.; Gloyn, A.L.; Lindgren, C.M.; Mägi, R.; Morris, A.P.; Randall, J.; Johnson, T.; Elliott, P.; Rybin, D.; Thorleifsson, G.; Steinthorsdottir, V.; Henneman, P. ... Mitchell, B.D (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42 (2), 105−116.10.1038/ng.520.
1.1.
2010
Mägi, R; Morris, AP. (2010). GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics, 11 (288), 288.10.1186/1471-2105-11-288.
1.1.
2010
Ingelsson, E.; Langenberg, C.; Hivert, M.F.; Prokopenko, I.; Lyssenko, V.; Dupuis, J.; Mägi, R.; Sharp, S.; Jackson, A.U.; Assimes, T.L.; Shrader, P.; Knowles, J.W.; Zethelius, B.; Abbasi, F.A.; Bergman, R.N.; Bergmann, A.; Berne, C.; Boehnke, M.; Bonnycastle, L.L.; Bornstein, S.R. ... Florez, JC. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. DIABETES, 59: 59th Annual Meeting of the American-Society-of-Human-Genetics; Honolulu, HI, USA; OCT 20-24, 2009. 1266−1275. (5).10.2337/db09-1568.
1.1.
2010
Freathy, R.M.; Mook-Kanamori, D.O.; Sovio, U.; Prokopenko, I.; Timpson, N.J.; Berry, D.J.; Warrington, N.M.; Widen, E.; Hottenga, J.J.; Kaakinen, M.; Lange, L.A.; Bradfield, J.P.; Kerkhof, M.; Marsh, J.A.; Mägi, R.; et, al. (2010). Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nature Genetics, 42 (5), 430−435.
1.1.
2010
Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; et, al.; Mägi, R.; et, al. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42 (5), 376−384.10.1038/ng.568.
1.1.
2010
Thorgeirsson, TE.; Gudbjartsson, DF.; Surakka, I.; Vink, JM.; Amin, N.; Geller, F.; Sulem, P.; Rafnar, T.; Esko, T.; Walter, S.; Gieger, C.; Rawal, R.; Mangino, M.; Prokopenko, I.; Mägi, R.; Keskitalo, K.; Gudjonsdottir, IH.; Gretarsdottir, S.; Stefansson, H.; Thompson, JR. ... Stefansson, K (2010). Sequence variants at CHRNB3-CHRNA6 and affect smoking behavior. Nature Genetics, 42 (5), 448−453.
5.1.
2010
Mägi, R.; Hottenga, J. J.; Prokopenko, I. (2010). A genome-wide association analysis of over 75,000 individuals identifies gender-specific effects for fasting glycaemic traits. Diabetologia, 53: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, SWEDEN, SEP 20-24, 2010. Springer, S28−S28.
5.1.
2010
Mägi, R; Morris, AP. (2010). GRANVIL: Rare Variant Analysis of Genome-Wide Association Studies. Genetic Epidemiology, 34: 19th Annual Meeting of the International-Genetic-Epidemiology-Society, Boston, MA, OCT 10-12, 2010. Wiley-Blackwell, 926−926. (8).
1.1.
2009
Nelis, M.; Esko, T.; Mägi, R.; Zimprich, F.; Zimprich, A.; Toncheva, D.; Karachanak, S.; Piskácková, T.; Balascák, I.; Peltonen, L.; Jakkula, E.; Rehnström, K.; Lathrop, M.; Heath, S.; Galan, P.; Schreiber, S.; Meitinger, T.; Pfeufer, A.; Wichmann, HE.; Melegh, B. ... Metspalu, A. (2009). Genetic structure of Europeans: a view from the North-East. PLoS ONE, 4(5), e5472.
5.1.
2009
Prokopenko, I; Dupuis, J; Langenberg, C; Saxena, R; Soranzo, N; Jackson, AU; Wheeler, E; Glazer, NL; Mägi, R; Bouatia-Naji, N; Florez, JC; Barroso, I. (2009). Novel genetic loci implicated in fasting glucose homeostasis and their impact on related metabolic traits. Diabetologia, 52: 45th Annual Meeting of the European-Association-for-the-Study-of-Diabetes, Vienna, AUSTRIA, SEP 30-OCT 02, 2009.. Springer, S38−S38.
1.1.
2008
Krjutskov, K.; Andreson, R.; Mägi, R.; Nikopensius, T.; Khrunin, A.; Mihailov, E.; Tammekivi, V.; Sork, H.; Remm, M.; Metspalu, A. (2008). Development of a single tube 640-plex genotyping method for detection of nucleic acid variations on microarrays. Nucleic Acids Research, 36 (12), e75.
1.1.
2008
Tamm, R.; Oselin, K.; Kallassalu, K.; Magi, R.; Anier, K.; Remm, M.; Metspalu, A. (2008). Thiopurine S-methyltransferase (TPMT) pharmacogenetics: three new mutations and haplotype analysis in the Estonian population. Clinical Chemistry and Laboratory Medicine, 46 (7), 974−979.
5.2.
2008
Oitmaa, Eneli; Krjutskov, Kaarel; Mägi, Reedik ; Andreson, Reidar ; Raukas, Elve; Remm, Maido; Tõnisson, Neeme; Schneider, Marion; Metspalu, Andres (2008). Molecular diagnostics of Down syndrome using quantitative APEX microarrays. RBM online, vol.16-suppl. 3: Eighth International Symposium of Preimplantation Genetic Diagnosis, Barcelona, April 23-26, 2008. S17.
1.1.
2007
Magi, R.; Pfeufer, A.; Nelis, M.; Montpetit, A.; Metspalu, A.; Remm, M. (2007). Evaluating the performance of commercial whole-genome marker sets for capturing common genetic variation. BMC Genomics, 8 (159), x.
1.1.
2007
Kuningas, M.; Mägi, R.; Westendorp, R.G.; Slagboom, P.E.; Remm, M.; van Heemst, D. (2007). Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. European Journal of Human Genetics, 15 (3), 294−301.10.1038/sj.ejhg.5201766.
1.1.
2006
Kaminski, S.; Brym, P.; Rusc, A.; Wojcik, E.; Ahman, A.; Mägi, R. (2006). Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (APEX) microarray. Animal biotechnology, 17 (1), 1−11.
1.1.
2006
Montpetit, A.; Nelis, M.; Laflamme, P.; Magi, R.; Ke, X.Y.; Remm, M.; Cardon, L.; Hudson, T.J.; Metspalu, A. (2006). An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. Plos Genetics, 2 (3), 282−290.
3.2.
2006
Mägi, R.; Kaplinski, L.; Remm, M. (2006). The Whole Genome TagSNP Selection and Transferability Among HapMap Populations. Pacific Symposium on Biocomputing 2006: 2006. World Scientific Publ Co Pte Ltd, 535−543.
1.1.
2005
Mueller, J. C.; Lõhmussaar, E.; Mägi, R.; Remm, M.; Bettecken, T.; Lichtner, P.; Huber, S.; Illig, T; Luedemann, J.; Schreiber, S.; Wichmann, H. E.; Pramstaller, P.; Romeo, G.; Testa, A.; Metspalu, A.; Meitinger, T. (2005). Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations. American Journal of Human Genetics, 76 (3), 387−398.
1.1.
2002
Liira, J.; Zobel, K.; Magi, R.; Molenberghs, G. (2002). Vertical structure of herbaceous canopies: the importance of plant growth-form and species-specific traits. Plant Ecology, 163 (1), 123−134.
1.1.
2002
Dawson, E.; Abecasis, GR.; Bumpstead, S.; Chen, Y.; Hunt, S.; Beare, DM.; Pabial, J.; Dibling, T.; Tinsley, E.; Kirby, S.; Carter, D.; Papaspyridonos, M.; Livingstone, S.; Ganske, R.; Lohmmussaar, E.; Zernant, J.; Tonisson, N.; Remm, M.; Magi, R.; Puurand, T. ... Dunham, I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature, 418 (6897), 544−548.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using APEX arrays. European Journal of Human Genetics, 10, 299−299.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Puurano, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using Arrayed Primer EXtension (APEX) technology. American Journal of Human Genetics, 71 (4), 449−449.
5.1.
2001
Metspalu, A.; Zernant, J.; Lohmussaar, E.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, L.; Pavel, H.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M. (2001). SNP analysis of the human chromosome 22 using APEX arrays. American Journal of Human Genetics, 69 (4), 408−408.

Industrial property

14.10.2019
Detailne otsing
  • Leitud 17 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0180026s09Bioinformaatika rakendamine genoomijärjestuste uurimiseks 01.01.200931.12.2014Maido RemmTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond546 107,92 EUR
2.2.1.VP1GV17047Epidemioloogiline uuring toitainete ja rasvumise rolli tuvastamiseks atoopilise dermatiidi ja akne puhul01.09.201731.12.2018Reedik MägiTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu70 463,52 EUR
SFSF0180142Cs08Geneetiline varieeruvus, elustiil ja keskkonnategurid kui peamised tervise mõjurid - EGV01.01.200831.12.2013Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu459 958,57 EUR
2.1.1.LP1GI19572 Geneetilist riskiskooride arendamine02.09.201930.06.2020Tõnu EskoTartu Ülikool, Tartu Ülikooli genoomika instituut118 876,00 EUR
TKSLTMR16142T (TK142)Genoomika ja Siirdemeditsiini Tippkeskus (TK142)01.01.201601.03.2023Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu4 474 349,50 EUR
SFSF0182649s04Inimese genoomi haplotüüpse struktuuri analüüs (0182649s04)01.01.200431.12.2008Maido RemmTartu Ülikool, Bioloogia-geograafiateaduskond224 329,88 EUR
ETFETF6041Konserveerunud järjestuselementide detekteerimine eukarüootsetes genoomides võrdleva genoomika abil01.01.200531.12.2006Maido RemmEesti Biokeskus12 910,15 EUR
MUUPP1GI19935Koopiaarvu muutuste mõju komplekshaigustele07.08.201930.06.2020Reedik MägiTartu Ülikool, Tartu Ülikooli genoomika instituut50 000,00 EUR
PRGPRG243Looduslik valik ja migratsioonid inimese geneetilise varieeruvuse kujunemisel Ida Euroopa lauskmaal. Vana-DNA uurimus01.01.201831.12.2022Mait MetspaluTartu Ülikool, Tartu Ülikooli genoomika instituut399 862,50 EUR
MUUVP1GV13124Metaboloomika ja genoomika uuring kehakaalu mõjutavate faktorite identifitseerimiseks05.07.201331.12.2016Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu810 800,00 EUR
MUUSBGMR06013Mobiilsustoetus Pacific Sypmosium of Biocomputing01.01.200611.01.2006Reedik MägiTartu Ülikool1 278,23 EUR
IUTIUT20-60Oomiksi põhised meetodid terviseuuringutes: integreeritud lähenemine haiguste tekkeprotsesside mõistmiseks ja prognoosimiseks01.01.201431.12.2019Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu; Tartu Ülikool, Tartu Ülikooli genoomika instituut1 327 800,00 EUR
MUUSP1GV15007TPersonaalse meditsiini pilootprojekt "Eestlaste genoomivarieeruvuse andmebaasi loomine"01.01.201531.08.2015Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu1 740 042,00 EUR
2.1.1.LP1GI19450 Polügeensete riskiskooride valideerimine Eesti Geenivaramu andmestikul20.06.201920.06.2022Tõnu EskoTartu Ülikool, Tartu Ülikooli genoomika instituut32 500,00 EUR
ETFETF9353Põhjuslike seoste analüüsi metoodika uuringutes mis kasutavad tavalist või Mendeli randomiseerimist01.01.201231.12.2015Krista FischerTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu60 000,00 EUR
MUUSP1GVARENGSiirdegenoomika keskus01.01.201131.12.2015Ursel Soomets; Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu3 500 000,00 EUR
1.2.3.4.; MUUMLTMR15148R (H2020-TWINN-2015 WIDENLIFE project #692056)WIDENLIFE01.01.201631.12.2018Ants KurgTartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut455 380,00 EUR