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Reedik Mägi

https://www.etis.ee/CV/Reedik_Mägi/est
18.08.1978
737 4045
reedik.magi@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2021–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, genoomika instituut, bioinformaatika professor (1,00)
19.08.2019–31.12.2020   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, bioinformaatika juhtivteadur (1,00)
01.01.2018–18.08.2019   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, bioinformaatika vanemteadur (1,00)
01.09.2016–31.12.2017   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, bioinformaatika vanemteadur (1,00)
01.09.2011–31.08.2016   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, statistilise geneetika vanemteadur (1,00)
01.02.2010–31.08.2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, teadur (0,10)
2009–2011   
University Of Oxford, Marie Curie Research Fellow in Wellcome Trust Centre for Human Genetics (1,00)
01.09.2008–31.08.2011   
Eesti Biokeskus, Erakorraline teadur (0,10)
01.04.2008–31.01.2010   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, erakorraline teadur (0,10)
2008–2011   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, Bioinformaatika õppetool, Erakorraline teadur (0,10)
2008–2009   
University Of Oxford, Senior Statistical Geneticist (1,00)
01.01.2008–31.12.2011   
Wellcome Trust Centre for Human Genetics, Univeristy of Oxford; postdok
01.01.2008–31.03.2008   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, erakorraline teadur (1,00)
01.12.2007–31.12.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.08.2007–30.11.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,10)
01.02.2007–31.07.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.09.2006–31.01.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.07.2006–31.08.2006   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.09.2005–30.06.2006   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.07.2005–31.08.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
01.02.2005–30.06.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (0,50)
01.02.2004–31.01.2005   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, erakorraline teadur (1,00)
2004–2008   
Tartu Ülikool, Tartu Ülikool, erak. teadur (0,50)
01.01.2002–2004   
OÜ Biodata, OÜ Biodata, IT spetsialist (0,50)
01.01.2000–31.12.2002   
AS Asper Biotech, IT spetsialist
 
 
Haridustee
2003–2007   
Tartu Ülikool bioinformaatika eriala doktoriõpe
2000–2003   
Tartu Ülikool taimeökoloogia eriala magistriõpe
1996–2000   
Tartu Ülikool botaanika ja ökoloogia eriala bakalaureuseõpe
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2016−...   
Igaaastase kursuse "Introduction to the statistical analysis of genome-wide association studies" Imperial College of London, UK kaasjuht
2017−2017   
Konverentsi "European Mathematical Genetics Meeting" organiseerija ja teaduskomitee liige

Kvalifikatsioon

Teaduskraadid
Reedik Mägi, doktorikraad, 2007, (juh) Maido Remm, The Linkage Disequilibrium And The Selection of Genetic markers For Association Studies in European Populations, Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut.
Reedik Mägi, magistrikraad (teaduskraad), 2003, (juh) Kristjan Zobel, Rohu- ja puhmarinde võra struktuur 27 Eesti niidu- ja metsakoosluses, Tartu Ülikool, Bioloogia-geograafiateaduskond, Botaanika ja ökoloogia instituut.
 
 
Teaduspreemiad ja tunnustused
2019, Reedik Mägi, Riigi teaduspreemia keemia ja molekulaarbioloogia alal teadustöö „Geneetika- ja genoomikaalased alusuuringud personaalmeditsiini rakendamiseks Eestis“ eest (Esko, Mägi, Fischer, Milani)
2009, Reedik Mägi, EC FP7 Marie Curie IEF (2009-2011)
2008, Reedik Mägi, Järeldoktorantuuri grant Eesti Biokeskusest (ECOGENE)
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.1. Biomeditsiin; CERCS KLASSIFIKAATOR: B100 Biomeditsiini ajalugu ja filosoofia, teoreetiline bioloogia, evolutsiooni üldised küsimused ; TÄPSUSTUS: Main scientific interests include population and statistical genetics, as well as software development for implementing statistical methods for genetic studies. I have worked on the development and implementation of methodology of meta-analysis, rare-variant analysis, and sequencing data analysis. I am also participating in several association studies, which are mainly related to T2D and various anthropometric phenotypes.

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2020
Marees, Andries T.; Gamazon, Eric R.; Gerring, Zachary; Vorspan, Florence; Fingal, Josh; van den Brink, Wim; Smit, Dirk J. A.; Verweij, Karin J. H.; Kranzler, Henry R.; Sherva, Richard; Farrer, Lindsay; Stringer, Sven; Minica, Camelia C.; Mbarek, Hamdi; Bernard, Manon; Derringer, Jaime; van Eijk, Kristel R.; Isen, Joshua D.; Loukola, Anu; Maciejewski, Dominique F. ... Derks, Eske M. (2020). Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci. Drug and Alcohol Dependence, 206, ARTN 107703. DOI: 10.1016/j.drugalcdep.2019.107703.
1.1.
2020
Li C, Stoma S, Lotta LA, Warner S, Albrecht E, et al. (2020). Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. The American Journal of Human Genetics , 106 (3), 389−404. DOI: 10.1016/j.ajhg.2020.02.006.
1.1.
2020
Pankratov, Vasili; Montinaro, Francesco; Kushniarevich, Alena; Hudjashov, Georgi; Jay, Flora; Saag, Lauri; Flores, Rodrigo; Marnetto, Davide; Seppel, Marten; Kals, Mart; Vosa, Urmo; Taccioli, Cristian; Mols, Mart; Milani, Lili; Aasa, Anto; Lawson, Daniel John; Esko, Tonu; Magi, Reedik; Pagani, Luca; Metspalu, Andres ... Metspalu, Mait (2020). Differences in local population history at the finest level: the case of the Estonian population. European Journal of Human Genetics, 28, 11, 1580−1591. DOI: 10.1038/s41431-020-0699-4.
1.1.
2020
Orthofer, Michael; Valsesia, Armand; Maegi, Reedik; Wang, Qiao-Ping; Kaczanowska, Joanna; Kozieradzki, Ivona; Leopoldi, Alexandra; Cikes, Domagoj; Zopf, Lydia M.; Tretiakov, Evgenii O.; Demetz, Egon; Hilbe, Richard; Boehm, Anna; Ticevic, Melita; Noukas, Margit; Jais, Alexander; Spirk, Katrin; Clark, Teleri; Amann, Sabine; Lepamets, Maarja ... Penninger, Josef M. (2020). Identification of ALK in Thinness. Cell, 181 (6), 1246−1285. DOI: 10.1016/j.cell.2020.04.034.
1.1.
2020
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei ... Fornage, Myriam (2020). Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry. DOI: 10.1038/s41380-020-0719-3.
1.1.
2020
Marnetto, Davide; Pärna, Katri; Läll, Kristi; Molinaro, Ludovica; Montinaro, Francesco; Haller, Toomas; Metspalu, Mait; Mägi, Reedik; Fischer, Krista; Pagani, Luca (2020). Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals. Nature Communications, 11 (1), 1628−1628. DOI: 10.1038/s41467-020-15464-w.
1.1.
2020
Bovijn, Jonas; Krebs, Kristi; Chen, Chia-Yen; Boxall, Ruth; Censin, Jenny C; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Laber, Samantha; Millwood, Iona Y; Lin, Kuang; Li, Liming; Chen, Zhengming; Milani, Lili; Smith, George Davey; Walters, Robin G; Mägi, Reedik; Neale, Benjamin M; Lindgren, Cecilia M; Holmes, Michael V (2020). Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics. Science Translational Medicine, 12 (549). DOI: 10.1126/scitranslmed.aay6570.
1.1.
2020
Joo, YY; Actkins, K; Pacheco, JA; Basile, AO; Carroll, R; Crosslin, DR; Day, F; Denny, JC; Velez Edwards, DR; Hakonarson, H; Harley, JB; Hebbring, SJ; Ho, K; Jarvik, GP; Jones, M; Karaderi, T; Mentch, FD; Meun, C; Namjou, B; Pendergrass, S ... International PCOS Consortium (including A Salumets) (2020). A Polygenic and Phenotypic Risk Prediction for Polycystic Ovary Syndrome Evaluated by Phenome-Wide Association Studies. Journal of Clinical Endocrinology and Metabolism, 105 (6), dgz326. DOI: 10.1210/clinem/dgz326.
1.1.
2020
Guo, Yanjun; Rist, Pamela M.; Daghlas, Iyas; Giulianini, Franco; International Headache Genetics Consortium; 23andMe Research Team; Kurth, Tobias; Chasman, Daniel, I (2020). A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. Nature Communications, 11 (1), ARTN 3368. DOI: 10.1038/s41467-020-17002-0.
1.1.
2020
Krebs, Kristi; Bovijn, Jonas; Zheng, Neil; Lepamets, Maarja; Censin, Jenny C; Jürgenson, Tuuli; Särg, Dage; Abner, Erik; Laisk, Triin; Luo, Yang; Skotte, Line; Geller, Frank; Feenstra, Bjarke; Wang, Wei; Auton, Adam; ,; Raychaudhuri, Soumya; Esko, Tõnu; Metspalu, Andres; Laur, Sven ... Fadista, João (2020). Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy. The American Journal of Human Genetics, 107 (4), 612−621. DOI: 10.1016/j.ajhg.2020.08.008.
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F.; Feufer, Arne P.; Marullo, Letizia; Magi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in Medicine, 13 (11), 931−940.10.2217/bmm-2017-0431.
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in Medicine, 21 (5), 1−8. DOI: 10.1038/s41436-018-0311-2.
1.1.
2019
Reisberg, Sulev; Galwey, Nicholas; Avillach, Paul; Sahlqvist, Anna-Stina; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Vilo, Jaak; James, Glen (2019). Comparison of variation in frequency for SNPs associated with asthma or liver disease between Estonia, HapMap populations and the 1000 genome project populations. International Journal of Immunogenetics, 46 (1), 1−10. DOI: 10.1111/iji.12413.
1.1.
2019
Tasa, T,; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 442−454. DOI: 10.1038/s41431-018-0300-6.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, 12 (5), 1050−1061.10.1111/eva.12780.
1.1.
2019
de Vries, Paul S.; Brown, Michael R.; Bentley, Amy R.; Sung, Yun J.; Winkler, Thomas W.; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T.; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E.; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Richard, Melissa A.; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C. (2019). Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology, 188 (6), 1033−1054. DOI: 10.1093/aje/kwz005.
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648. DOI: 10.1038/s41588-019-0378-y.
1.1.
2019
Saag, Lehti; Laneman, Margot; Varul, Liivi; Malve, Martin; Valk, Heiki; Razzak, Maria A.; Shirobokov, Ivan G.; Khartanovich, Valeri I.; Mikhaylova, Elena R.; Kushniarevich, Alena; Scheib, Christiana Lyn; Solnik, Anu; Reisberg, Tuuli; Parik, Juri; Saag, Lauri; Metspalu, Ene; Rootsi, Siiri; Montinaro, Francesco; Remm, Maido; Magi, Reedik ... Tambets, Kristiina (2019). The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East. Current Biology, 29 (10), 1701−1728.10.1016/j.cub.2019.04.026.
1.1.
2019
Justice, Anne E; Karaderi, Tugce; Highland, Heather M; Young, Kristin L; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L; Fine, Rebecca S; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W; Locke, Adam E; Medina-Gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush ... Lindgren, Cecilia M (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51 (3), 452−469.10.1038/s41588-018-0334-2.
1.1.
2019
Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; ,; ,; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D ... Vrieze, Scott (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51 (2), 237−248. DOI: 10.1038/s41588-018-0307-5.
1.1.
2019
Bovijn, Jonas; Jackson, Leigh; Censin, Jenny; Chen, Chia-Yen; Laisk, Triin; Laber, Samantha; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Smoller, Jordan W; Harrison, Jamie W; Ruth, Katherine S; Beaumont, Robin N; Jones, Samuel E; Tyrrell, Jessica; Wood, Andrew R; Weedon, Michael N; Mägi, Reedik; Neale, Benjamin; Lindgren, Cecilia M ... Holmes, Michael V (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. The American Journal of Human Genetics, 104 (1), 157−163.10.1016/j.ajhg.2018.11.004.
1.1.
2019
Wiberg, Akira; Ng, Michael; Schmid, Annina B.; Smillie, Robert W.; Baskozos, Georgios; Holmes, Michael V.; Kunnapuu, K.; Magi, R.; Bennett, David L.; Furniss, Dominic (2019). A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nature Communications, 10, ARTN 1030.10.1038/s41467-019-08993-6.
1.1.
2019
James, Glen; Reisberg, Sulev; Lepik, Kaido; Galwey, Nicholas; Avillach, Paul; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Alexander, Myriam; Waterworth, Dawn; Loomis, A. Katrina; Vilo, Jaak (2019). An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank. PLoS ONE, 14 (4), ARTN e0215026. DOI: 10.1371/journal.pone.0215026.
1.1.
2019
Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B.; Feitosa, Mary F.; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y.; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O.; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar ... Pattaro, Cristian (2019). A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51 (6), 957−976. DOI: 10.1038/s41588-019-0407-x.
1.1.
2019
Deng, Wei Q.; Mao, Shihong; Kalnapenkis, Anette; Esko, Tonu; Magi, Reedik; Pare, Guillaume; Sun, Lei (2019). Analytical strategies to include the X-chromosome in variance heterogeneity analyses: Evidence for trait-specific polygenic variance structure. Genetic Epidemiology. DOI: 10.1002/gepi.22247.
1.1.
2019
Tin, Adrienne; Marten, Jonathan; Kuhns, Victoria L. Halperin; Li, Yong; Wuttke, Matthias; Kirsten, Holger; Sieber, Karsten B.; Qiu, Chengxiang; Gorski, Mathias; Yu, Zhi; Giri, Ayush; Sveinbjornsson, Gardar; Li, Man; Chu, Audrey Y.; Hoppmann, Anselm; O'Connor, Luke J.; Prins, Bram; Nutile, Teresa; Noce, Damia; Akiyama, Masato ... Koettgen, Anna (2019). Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics, 51 (10), 1459−1478. DOI: 10.1038/s41588-019-0504-x.
1.1.
2019
Linner, Richard Karlsson; Biroli, Pietro; Kong, Edward; Meddens, Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Mael; Tino, Stephen P.; Abdellaoui, Abdel; Hammerschlag, Anke R.; Nivard, Michel G.; Okbay, Aysu; Rietveld, Cornelius A.; Timshel, Pascal N.; Trzaskowski, Maciej; de Vlaming, Ronald; Zund, Christian L.; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H. ... Beauchamp, Jonathan P. (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 (2), 245−261. DOI: 10.1038/s41588-018-0309-3.
5.1.
2019
Lepamets, Maarja; Lepik, Kaido; Kutalik, Zoltàn; Mägi, Reedik (2019). Genome-wide copy number variant association study reveals several novel disease-associated loci. European Journal of Human Genetics, 27: 52nd Conference of the European Society of Human Genetics (ESHG); Gothenburg, Sweden; June 15-18, 2019. Nature Publishing Group, 1114−1114.
5.1.
2019
Bovijn J., Krebs K., Chen C., Boxall R., Censin JC., Ferreira T., Pulit SL., Glastonbury CA., Laber S., Millwood IY., Lin K., Li L., Chen Z., Milani L., Walters RG., Mägi R., Neale BM., Lindgren CM., Holmes MV. (2019). Lifelong genetically lowered sclerostin and risk of cardiovascular disease. Eur J Hum Genet, 27: Abstracts from the 52nd European Society of Human Genetics (ESHG) Conference: Oral Presentations.. Nature, 1120−1121. (10; S2).
5.2.
2019
Eltermaa, Mall; Jakobson, Maili; Utt, Meeme; Kõks, Sulev; Mägi, Reedik; Starkopf, Joel (2019). Geneetilistel variantidel humaniini nukleaarsete isovormide geenides ei ole statistiliselt olulist seost koronaararteri haigusega. Eesti Arst, 98. OÜ Celsius Healthcare, 36−36.
6.7.
2019
Kals, Mart; Nikopensius, Tiit; Läll, Kristi; Pärn, Kalle; Tõnis Sikka, Timo; Suvisaari, Jaana; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Metspalu, Andres; Esko, Tõnu; Palta, Priit; Mägi, Reedik; (2019). Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses. bioRxiv, 579201. DOI: 10.1101/579201.
6.7.
2019
Männik, Katrin; Arbogast, Thomas; Lepamets, Maarja; Lepik, Kaido; Pellaz, Anna; Ademi, Herta; Kupchinsky, Zachary A; Ellegood, Jacob; Attanasio, Catia; Messina, Andrea; Rotman, Samuel; Martin-Brevet, Sandra; Dubruc, Estelle; Chrast, Jacqueline; Lerch, Jason P; Qiu, Lily R; Laisk, Triin; The 16p11.2 European Consortium; The Simons VIP Consortium; The eQTLGen Consortium ... Reymond, Alexandre (2019). Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus. bioRxiv. DOI: 10.1101/716415.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. The American Journal of Human Genetics, 102 (3), 375−400. DOI: 10.1016/j.ajhg.2018.01.015.
1.1.
2018
Pervjakova, N.; Kukushkina, V.; Haller, T.; Kasela, S.; Joensuu, A.; Kristiansson, K.; Annilo, T.; Perola, M.; Salomaa, V.; Jousilahti, P.; Metspalu, A.; Magi, R. (2018). Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene. Biomarkers in Medicine, 12 (5), 439−446. DOI: 10.2217/bmm-2018-0020.
1.1.
2018
Suhorutshenko, Marina; Kukushkina, Viktorija; Velthut-Meikas, Agne; Altmäe, Signe; Peters, Maire; Mägi, Reedik; Krjutškov, Kaarel; Koel, Mariann; Codoñer, Francisco; Martinez-Blanch, Juan; Vilella, Felipe; Simón, Carlos; Salumets, Andres; Laisk, Triin (2018). Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. Human Reproduction, 33 (11), 2074−2086. DOI: 10.1093/humrep/dey301.
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Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166. DOI: 10.1371/journal.pone.0198166.
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Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121. DOI: 10.1038/s41588-018-0147-3.
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Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. The Journal of Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
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Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516. DOI: 10.1038/s41588-018-0241-6.
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Pasman, Joëlle A; Verweij, Karin J H; Gerring, Zachary; Stringer, Sven; Sanchez-Roige, Sandra; Treur, Jorien L; Abdellaoui, Abdel; Nivard, Michel G; Baselmans, Bart M L; Ong, Jue-Sheng; Ip, Hill F; van der Zee, Matthijs D; Bartels, Meike; Day, Felix R; Fontanillas, Pierre; Elson, Sarah L; ,; de Wit, Harriet; Davis, Lea K; MacKillop, James ... Vink, Jacqueline M (2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21 (9), 1161−1170.10.1038/s41593-018-0206-1.
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Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429. DOI: 10.1038/s41588-018-0205-x.
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Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571. DOI: 10.1038/s41588-018-0084-1.
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Vals, Mari-Anne; Pajusalu, Sander; Kals, Mart; Magi, Reedik; Ounap, Katrin (2018). The Prevalence of PMM2-CDG in Estonia Based on Population Carrier Frequencies and Diagnosed Patients. In: JIMD REPORTS, VOL 39 (13−17).06.07.2017 BERLIN: SPRINGER-VERLAG BERLIN. (39).10.1007/8904_2017_41.
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Lepamets, Maarja; Lepik, Kaido; Kals, Mart; Carmeli, Cristian; Claringbould, Annique; Bochud, Murielle; Stringhini, Silvia; Wijmenga, Cisca; Franke, Lude; Mägi, Reedik; Kutalik, Zoltàn (2018). New Quality Measure for CNV: A Multi-Omics Approach. Human Heredity, 83: 46th European Mathematical Genetics Meeting (EMGM); Cagliari, Italy; April 18-20, 2018. Karger, 16−16.
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Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez ... McCarthy, Mark I (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5, 180002−180002. DOI: 10.1038/sdata.2018.2.
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2017
Huan, Tianxiao; Joehanes, Roby; Schurmann, Claudia; Schramm, Katharina; Pilling, Luke C; Peters, Marjolein J; Mägi, Reedik; DeMeo, Dawn; O'Connor, George T; Ferrucci, Luigi; Teumer, Alexander; Homuth, Georg; Biffar, Reiner; Völker, Uwe; Herder, Christian; Waldenberger, Melanie; Peters, Annette; Zeilinger, Sonja; Metspalu, Andres; Hofman, Albert ... Levy, Daniel (2017). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics, 25 (21), 1−33. DOI: 10.1093/hmg/ddw288.
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Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201. DOI: 10.1038/mp.2016.71.
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Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences, 114 (3), E327−E336. DOI: 10.1073/pnas.1619052114.
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Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 3, 403−415. DOI: 10.1038/ng.3768.
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Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110. DOI: 10.1186/s12859-017-1530-2.
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Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25.10.1186/s12859-016-1437-3.
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R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical Pharmacology & Therapeutics, 101 (5), 684−695. DOI: 10.1002/cpt.540.
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Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186. DOI: 10.1038/ng.3912.
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Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genetics, 13 (6), e1006812. DOI: 10.1371/journal.pgen.1006812.
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Kukushkina, Viktorija; Modhukur, Vijayachitra; Suhorutsenko, Marina; Peters, Maire; Magi, Reedik; Rahmioglu, Nilufer; Velthut-Meikas, Agne; Altmae, Signe; Esteban, Francisco J.; Vilo, Jaak; Zondervan, Krina; Salumets, Andres; Laisk-Podar, Triin (2017). DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase. Scientific Reports, 7, ARTN 3916. DOI: 10.1038/s41598-017-03682-0.
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2017
Eichstaedt, Christina A; Pagani, Luca; Antao, Tiago; Inchley, Charlotte E; Cardona, Alexia; Mörseburg, Alexander; Clemente, Florian J; Sluckin, Timothy J; Metspalu, Ene; Mitt, Mario; Mägi, Reedik; Hudjashov, Georgi; Metspalu, Mait; Mormina, Maru; Jacobs, Guy S; Kivisild, Toomas (2017). Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations. Scientific Reports, 7 (1), 13042−13042.10.1038/s41598-017-13382-4.
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Kraja, Aldi T.; Cook, James P.; Warren, Helen R.; Surendran, Praveen; Liu, Chunyu; Evangelou, Evangelos; Manning, Alisa K.; Grarup, Niels; Drenos, Fotios; Sim, Xueling; Smith, Albert Vernon; Amin, Najaf; Blakemore, Alexandra I. F.; Bork-Jensen, Jette; Brandslund, Ivan; Farmaki, Aliki-Eleni; Fava, Cristiano; Ferreira, Teresa; Herzig, Karl-Heinz; Giri, Ayush ... Howson, Joanna M. M. (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals. Circulation Cardiovascular Genetics, 10 (5), UNSP e001778.10.1161/CIRCGENETICS.117.001778.
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Mägi, R; Horikoshi, M; Sofer, T; Mahajan, A; Kitajima, H; Franceschini, N; McCarthy, MI; COGENT-Kidney, Consortium; T2D-GENES, Consortium; Morris, AP (2017). Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Human Molecular Genetics, 26 (18), 3639−3650.10.1093/hmg/ddx280.
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Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N. William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez ... McCarthy, Mark I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, ARTN 170179. DOI: 10.1038/sdata.2017.179.
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Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish; Emdin, Connor; Alam, Dewan; Alves, Alexessander Couto; Amouyel, Philippe; Di Angelantonio, Emanuele; Arveiler, Dominique; Assimes, Themistocles L.; Auer, Paul L.; Baber, Usman; Ballantyne, Christie M.; Bang, Lia E.; Benn, Marianne; Bis, Joshua C. ... Kathiresan, Sekar (2017). Exome-wide association study of plasma lipids in > 300,000 individuals. Nature Genetics, 49 (12), 1758−1772. DOI: 10.1038/ng.3977.
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Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994.10.1038/ejhg.2017.90.
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Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung ... Lindgren, Cecilia M. (2017). A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 66 (7), 2019−2032. DOI: 10.2337/db16-1329.
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Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845. DOI: 10.1038/ng.3841.
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Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D. ... Kilpelainen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults. PLoS Genetics, 13 (4), ARTN e1006528. DOI: 10.1371/journal.pgen.1006528.
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Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia; Gaulton, Kyle J.; Kaakinen, Marika; Pervjakova, Natalia; Pers, Tune H.; Johnson, Andrew D.; Eicher, John D.; Jackson, Anne U.; Ferreira, Teresa; Lee, Yeji; Ma, Clement; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Van Zuydam, Natalie R.; Mahajan, Anubha; Chen, Han ... Prokopenko, Inga (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes, 66 (11), 2888−2902. DOI: 10.2337/db16-1253.
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Mitt, Mario; Kals, Mart; Parn, Kalle; Gabriel, Stacey B; Lander, Eric S; Palotie, Aarno; Ripatti, Samuli; Morris, Andrew P; Metspalu, Andres; Esko, Tonu; Magi, Reedik; Palta, Priit; (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. European Journal of Human Genetics, 25 (7), 869−879. DOI: 10.1038/ejhg.2017.51.
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Rahmioglu, Nilufer; Lockstone, Helen; Ferreira, Teresa; Magi, Reedik; Van De Bunt, Martijn; Lindgren, Cecilia; Morris, Andrew; Becker, Christian; Zondervan, Krina (2017). Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis. Reproductive Sciences, 24, 205A−206A.
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Kaakinen, Marika; Magi, Reedik; Lagou, Vasiliki; Claringbould, Annique; Gaulton, Kyle; Fischer, Krista; Morris, Andrew; Prokopenko, Inga (2017). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. Genetic Epidemiology, 41 (7), 652−653.
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Suhorutshenko, M.; Kukushkina, V.; Velthut-Meikas, A.; Altmae, S.; Maire, P.; Magi, R.; Codoner, F.; Vilella, F.; Simon, C.; Salumets, A.; Laisk-Podar, T. (2017). Transcriptomic profile of early and mid-secretory endometrium revealed by RNA-seq: a paired sample cohort study. FEBS Journal, 284, 134−134.
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Teumer, A.; Qi, Q.; Nethander, M.; Aschard, H.; Bandinelli, S.; Beekman, M.; Berndt, S. I.; Bidlingmaier, M.; Broer, L.; Cappola, A.; Ceda, G. P.; Chanock, S.; Chen, M. -H.; Chen, T. C.; Chen, Y. -D. I.; Chung, J.; Miglianico, Del Greco F.; Eriksson, J.; Ferrucci, L.; Friedrich, N. ... Kaplan, R. C. (2017). Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016). Aging Cell, 16 (4), 898−898. DOI: 10.1111/acel.12612.
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Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Elliott, Paul (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (vol 49, pg 403, 2017). Nature Genetics, 49 (10), 1558−1558. DOI: 10.1038/ng1017-1558a.
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Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroula ... Loos, Ruth J F (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7, 10495−10495.10.1038/ncomms10495.
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Hägg, S; Fall, T; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Kals, M; de Vries, PS; Dehghan, A; Willems, SM; Sarin, AP; Kristiansson, K; Nuotio, ML; Havulinna, AS; de Bruijn, RF; Ikram, MA; Kuningas, M; Stricker, BH; Franco, OH; Benyamin, B ... European, Network, for, Genetic, and, Genomic, Epidemiology, (ENGAGE) consortium. (2015). Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. International Journal of Epidemiology, 44 (2), 578−586. DOI: 10.1093/ije/dyv094.
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2015
Day, Felix R; Ruth, Katherine S; Thompson, Deborah J; Lunetta, Kathryn L; Pervjakova, Natalia; Chasman, Daniel I; Stolk, Lisette; Finucane, Hilary K; Sulem, Patrick; Bulik-Sullivan, Brendan; Esko, Tõnu; Johnson, Andrew D; Elks, Cathy E; Franceschini, Nora; He, Chunyan; Altmaier, Elisabeth; Brody, Jennifer A; Franke, Lude L; Huffman, Jennifer E; Keller, Margaux F ... Murray, Anna (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47 (11), 1294−303. DOI: 10.1038/ng.3412.
1.1.
2015
Männik, Katrin; Mägi, Reedik; Macé, Aurélien; Cole, Ben; Guyatt, Anna L; Shihab, Hashem A; Maillard, Anne M; Alavere, Helene; Kolk, Anneli; Reigo, Anu; Mihailov, Evelin; Leitsalu, Liis; Ferreira, Anne-Maud; Nõukas, Margit; Teumer, Alexander; Salvi, Erika; Cusi, Daniele; McGue, Matt; Iacono, William G; Gaunt, Tom R ... Reymond, Alexandre (2015). Copy Number Variations and Cognitive Phenotypes in Unselected Populations. JAMA: the journal of the American Medical Association, 313 (20), 2044−2054. DOI: 10.1097/01.ogx.0000471594.65931.90.
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2015
Karmin, Monika; Saag, Lauri; Vicente, Mário; Wilson Sayres, Melissa A; Järve, Mari; Talas, Ulvi Gerst; Rootsi, Siiri; Ilumäe, Anne-Mai; Mägi, Reedik; Mitt, Mario; Pagani, Luca; Puurand, Tarmo; Faltyskova, Zuzana; Clemente, Florian; Cardona, Alexia; Metspalu, Ene; Sahakyan, Hovhannes; Yunusbayev, Bayazit; Hudjashov, Georgi; DeGiorgio, Michael ... Kivisild, Toomas (2015). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Genome Research, 25 (4), 459−466. DOI: 10.1101/gr.186684.114.
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2015
Joshi, Peter K.; Esko, Tõnu; Mattsson, Hannele; Eklund, Niina; Gandin, Ilaria; Nutile, Teresa; Jackson, Anne U.; Schurmann, Claudia; Smith, Albert V.; Zhang, Weihua; Okada, Yukinori; Stancakova, Alena; Faul, Jessica D.; Zhao, Wei; Bartz, Traci M.; Concas, Maria Pina; Franceschini, Nora; Enroth, Stefan; Vitart, Veronique; Trompet, Stella ... Wilson, James F. (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523 (7561), 459−476. DOI: 10.1038/nature14618.
5.1.
2015
Kaakinen, M.; Maegi, R.; Fischer, K.; Jarvelin, M. -R.; Morris, A. P.; Prokopenko, I. (2015). A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants. Human Heredity, 79: 43rd European Mathematical Genetics Meeting (EMGM), Brest, FRANCE, APR 16-17, 2015. Karger, 39−39. (1).
1.1.
2014
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y14; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J ... Frayling, TM. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173−1186. DOI: 10.1038/ng.3097.
1.1.
2014
Clemente, FJ.; Cardona, A.; Inchley, CE.; Peter, BM.; Jacobs, G.; Pagani, L.; Lawson, DJ.; Antao, T.; Vicente, M.; Mitt, M.; DeGiorgio, M.; Faltyskova, Z.; Xue, YL.; Ayub, Q.; Szpak, M.; Magi, R.; Eriksson, A.; Manica, A.; Raghavan, M.; Rasmussen, M. ... Kivisild, T. (2014). A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. The American Journal of Human Genetics, 95 (5), 584−589.10.1016/j.ajhg.2014.09.016.
1.1.
2014
Dimas, AS; Lagou, V; Barker, A; Knowles, JW; Magi, R; Hivert, MF; Benazzo, A; Rybin, D; Jackson, AU; Stringham, HM; Song, C; Fischer-Rosinsky, A; Boesgaard, TW; Grarup, N; Abbasi, FA; Assimes, TL; Hao, K; Yang, X Lecoeur, C; Barroso, I; Bonnycastle, LL ... MAGIC, Investigators. (2014). Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity. Diabetes, 63 (6), 2158−2171.10.2337/db13-0949.
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2014
Perry, J.R.B.; Day, F.; Elks, C.E.; Sulem, P.; Thompson, D.J.; Ferreira, T.; He, C.; Chasman, D.I.; Esko, T.; Thorleifsson, G.; Albrecht, E.; Ang, W.Q.; Corre, T.; Cousminer, D.L.; Feenstra, B.; Franceschini, N.; Ganna, A.; Johnson, A.D.; Kjellqvist, S.; Lunetta, K.L. ... Ong, K.K. (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92. DOI: 10.1038/nature13545.
1.1.
2014
Hoggart, CJ; Venturini, G; Mangino, M; Gomez, F; Ascari, G; Zhao, JH; Teumer, A; Winkler, TW; Tsernikova, N; Luan, J; Mihailov, E; Ehret, GB; Zhang, W; Lamparter, D; Esko, T; Mace, A; Rueger, S; Bochud, P-Y; Barcella, M; Dauvilliers, Y ... Kutalik, Z. (2014). Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. PLoS Genetics, 10 (7), e1004508. DOI: 10.1371/journal.pgen.1004508.
1.1.
2014
Metsalu, Tauno; Viltrop, Triin; Tiirats, Airi; Rajashekar, Balaji; Reimann, Ene; Kõks, Sulev; Rull, Kristiina; Milani, Lili; Acharya, Ganesh; Basnet, Purusotam; Vilo, Jaak; Mägi, Reedik; Metspalu, Andres; Peters, Maire; Haller-Kikkatalo, Kadri; Salumets, Andres (2014). Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. Epigenetics, 9 (10), 1397−1409. DOI: 10.4161/15592294.2014.970052.
1.1.
2014
Lim, ET.; Würtz, Peter; Havulinna, AS.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, RM.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina ... SISu, Project (2014). Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. PLoS Genetics, 10 (7), e1004494. DOI: 10.1371/journal.pgen.1004494.
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2014
Mägi, Reedik; Metspalu, Andres; Mihailov, Evelin (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234−244. DOI: 10.1038/ng.2897.
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2014
Schramm, Katharina; Marzi, Carola; Schurmann, Claudia; Carstensen, Maren; Reinmaa, Eva; Biffar, Reiner; Eckstein, Gertrud; Gieger, Christian; Grabe, Hans-Jorgen; Homuth, Georg; Kastenmuller, Gabriele; Magi, Reedik; Metspalu, Andres; Mihailov, Evelin; Peters, Annette; Petersmann, Astrid; Roden, Michael; Strauch, Konstantin; Suhre, Karsten; Teumer, Alexander ... Prokisch, Holger (2014). Mapping the genetic architecture of gene regulation in whole blood. PLoS ONE, 9 (4), e93844−e93844. DOI: 10.1371/journal.pone.0093844.
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2014
Winkler, T.W.; Day, FR.; Croteau-Chonka, DC.; Wood, AR.; Locke, AE.; Magi, R.; Ferreira, T.; Fall, T.; Graff, M.; Justice, AE.; Luan, JA.; Gustafsson, S.; Randall, JC.; Vedantam, S.; Workalemahu, T.; Kilpelainen, TO.; Scherag, A.; Esko, T.; Kutalik, Z.; Heid, IM. ... Loos, RJF (2014). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5), 1192−1212. DOI: 10.1038/nprot.2014.071.
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2014
Prokopenko, Inga; Poon, Wenny; Magi, Reedik; Prasad B, Rashmi; Salehi, S Albert; Almgren, Peter; Osmark, Peter; Bouatia-Naji, Nabila; Wierup, Nils; Fall, Tove; Stancakova, Alena; Barker, Adam; Lagou, Vasiliki; Osmond, Clive; Xie, Weijia; Lahti, Jari; Jackson, Anne U; Cheng, Yu-Ching; Liu, Jie; O'Connell, Jeffrey R ... Lyssenko, Valeriya (2014). A central role for GRB10 in regulation of islet function in man. PLoS Genetics, 10 (4), e1004235−e1004235.10.1371/journal.pgen.1004235.
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2014
Lokk, Kaie; Modhukur, Vijayachitra; Rajashekar, Balaji; Märtens, Kaspar; Mägi, Reedik; Kolde, Raivo; Koltšina, Marina; Nilsson, Torbjörn K.; Vilo, Jaak; Salumets, Andres; Tõnisson, Neeme (2014). DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biology, 15 (4), R54.10.1186/gb-2014-15-4-r54.
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2014
Fischer, K.; Kettunen, J.; Würtz, P.; Haller, T.; Aki S. Havulinna, A.S.; Kangas, A.J.; Soininen, P.; Esko, T.; Tammesoo, M-L.; Mägi, R.; Smit, S.; Palotie, A.; SRipatti, S.; Veikko Salmaa, V.; Ala-Korpela, M.; Perola, M.; Metspalu, A. (2014). Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons. PLoS Medicine, 11 (2), e1001606. DOI: 10.1371/journal.pmed.1001606.
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2014
Raghavan, M.; Skoglund, P.; Graf, K.E.; Metspalu, M.; Albrechtsen, A.; Moltke, I.; Rasmussen, S.; Stafford, T.W. Jr.; Orlando, L.; Metspalu, E.; Karmin, M.; Tambets, K.; Rootsi, S.; Mägi, R.; Campos, P.F., Balanovska, E., Balanovsky, O., Khusnutdinova, E., Litvinov, S.; Osipova, L.P.; Fedorova, S.A.; Voevoda, M.I.; DeGiorgio, M.; Sicheritz-Ponten, T. ... Willerslev, E. (2014). Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature, 505 (7481), 87−91.10.1038/nature12736.
1.1.
2014
Walsh, KM; Codd, V; Smirnov, IV; Rice, T; Decker, PA; Hansen, HM; Kollmeyer, T; Kosel, ML; Molinaro, AM; McCoy, LS; Bracci, PM; Cabriga, BS; Pekmezci, M; Zheng, SC; Wiemels, JL; Pico, AR; Tihan, T; Berger, MS; Chang, SM; Prados, MD ... ENGAGE, Consortium, Teleomere, Grp. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46 (7), 731−735. DOI: 10.1038/ng.3004.
5.1.
2014
Morris, A. P.; Teslovich, T. M.; Ferreira, T.; Mahajan, A.; Lee, Y.; Rayner, N. W.); Magi, R. (2014). Fine-mapping type 2 diabetes susceptibility loci with high-density imputation. DIABETOLOGIA, 57: 50th EASD Annual Meeting, Vienna, Austria, 15-19.09.2014. Springer, S50−S51.
1.1.
2013
Mägi, R.; Manning, S.; Yousseif, A.; Pucci, A.; Santini, F.; Karra, E.; Querci, G.; Pelosini, C.; McCarthy, M.I.; Lindgren, C.M.; Batterham, R.L. (2013). Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery. PLoS ONE, 8 (8), e70735.10.1371/journal.pone.0070735.
1.1.
2013
Evans, DM; Brion, MJ; Paternoster, L; Kemp, JP; McMahon, G; Munafò, M; Whitfield, JB; Medland, SE; Montgomery, GW; GIANT, Consortium; CRP, Consortium; TAG, Consortium; Timpson, NJ; St Pourcain, B; Lawlor, DA; Martin, NG; Dehghan, A; Hirschhorn, J; Davey, Smith, G. (2013). Mining the human phenome using allelic scores that index biological intermediates. PLoS Genetics, 9 (10), e1003919−e1003919. DOI: 10.1371/journal.pgen.1003919.
1.1.
2013
Vimaleswaran, KS.; Berry, DJ.; Lu, C.; Tikkanen, E.; Pilz, S.; Hiraki, LT.; Cooper, JD.; Dastani, Z.; Li, R.; Houston, DK.; Wood, AR.; Michaëlsson, K.; Vandenput, L.; Zgaga, L.; Yerges-Armstrong, LM.; McCarthy, MI.; Dupuis, J.; Kaakinen, M.; Kleber, ME.; Jameson, K. ... Hyppönen, E. (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Medicine, 10 (2), e1001383. DOI: 10.1371/journal.pmed.1001383.
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2013
Paul, Dirk S.; Albers, Cornelis A.; Rendon, Augusto; Voss, Katrin; Stephens, Jonathan; HaemGen, Consortium; van der Harst, Pim; Chambers, John C.; Soranzo, Nicole; Ouwehand, Willem H.; Deloukas, Panos (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Research, 23 (7), 1130−1141. DOI: 10.1101/gr.155127.113.
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2013
Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpeläinen, TO; Esko, T; Mägi, R; Li, S; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A ... Heid, IM (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics, 9 (6), e1003500. DOI: 10.1371/journal.pgen.1003500.
1.1.
2013
Thorgeirsson, TE; Gudbjartsson, DF; Sulem, P; Besenbacher, S; Styrkarsdottir, U; Thorleifsson, G; Walters, GB; TAG, Consortium; Oxford-GSK, Consortium; ENGAGE, consortium; Furberg, H; Sullivan, PF; Marchini, J; McCarthy, MI; Steinthorsdottir, V; Thorsteinsdottir, U; Stefansson, K. (2013). A common biological basis of obesity and nicotine addiction. Translational Psychiatry, 3, 1−7. DOI: 10.1038/tp.2013.81.
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2013
Tammiste, Anu; Jiang, Tao; Fischer, Krista; Mägi, Reedik; Krjutškov, Kaarel; Pettai, Kristi; Esko, Tõnu; Li, Yingrui; Tansey, Katherine E; Carroll, Liam S; Uher, Rudolf; McGuffin, Peter; Võsa, Urmo; Tšernikova, Natalia; Saria, Alois; Ng, Pauline C; Eller, Triin; Vasar, Veiko; Nutt, David J; Maron, Eduard ... Metspalu, Andres (2013). Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression. Journal of Psychopharmacology, 27 (10), 915−920. DOI: 10.1177/0269881113499829.
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2013
Fall, T.; Hagg, S.; Magi, R.; Ploner, A.; Fischer, K.; Horikoshi, M.; Sarin, AP.; Thorleifsson, G.; Ladenvall, C.; Kals, M.; Kuningas, M.; Draisma, HHM.; Ried, JS.; van Zuydam, NR.; Huikari, V.; Mangino, M.; Sonestedt, E.; Benyamin, B.; Nelson, CP.; Rivera, NV. ... Prokopenko, I. (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Medicine, 10 (6), e1001474−e1001474. DOI: 10.1371/journal.pmed.1001474.
1.1.
2013
Migliano, A.; Romero, I.; Metspalu, M.; Leavesley, M.; Pagani, L.; Antao, T.; Huang, D.; Sherman, B.; Siddle, K.; Scoles, C.; Hudjashov, G.; Kaitokai, E.; Mandui, H.; Babalu, A.; Belatti, M.; Cagan, A.; Hopkinshow, B.; Show, C.; Tabbada, K.; Nelis, M. ... Kivisild, T. (2013). Evolution of the pygmy phenotype: evidence of positive selection from genome-wide scans in African, Asian and Melanesian pygmies. Human Biology, 85, 251−284.
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2013
Nikopensius, T; Annilo, T; Jagomägi, T; Gilissen, C; Kals, M; Krjutškov, K; Mägi, R; Eelmets, M; Gerst-Talas, U; Remm, M; Saag, M; Hoischen, A; Metspalu, A (2013). Non-syndromic Tooth Agenesis Associated with a Nonsense Mutation in Ectodysplasin-A (EDA). Journal of Dental Research, 92 (6), 507−511. DOI: 10.1177/0022034513487210.
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2013
Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69. DOI: 10.1038/ng.2606.
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2013
Codd, V; Nelson, CP; Albrecht, E; Mangino, M; Deelen, J; Buxton, JL; Hottenga, JJ; Fischer, K; Esko, T; Surakka, I; Broer, L; Nyholt, DR; Leach, IM; Salo, P; Hägg, S; Matthews, MK; Palmen, J; Norata, GD; O'Reilly, PF; Saleheen, D ... Samani, NJ (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45 (4), 422−427. DOI: 10.1038/ng.2528.
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2013
Hu, YJ; Berndt, SI; Gustafsson, S; Ganna, A; Genetic Investigation of ANthropometric Traits (GIANT), Consortium; Hirschhorn, J; North, KE; Ingelsson, E; Lin, DY (2013). Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. The American Journal of Human Genetics, 93 (2), 236−248.10.1016/j.ajhg.2013.06.011.
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2013
Parsa, A; Fuchsberger, C; Köttgen, A; O'Seaghdha, CM; Pattaro, C; de Andrade, M; Chasman, DI; Teumer, A; Endlich, K; Olden, M; Chen, MH; Tin, A; Kim, YJ; Taliun, D; Li, M; Feitosa, M; Gorski, M; Yang, Q; Hundertmark, C; Foster, MC ... Böger, CA. (2013). Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function. Journal of the American Society of Nephrology, 24 (12), 2105−2117. DOI: 10.1681/ASN.2012100983.
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2013
Lagou, V.; Mägi, R.; Surakka, I. ; Sarin, A. -P.; Horikoshi, M.; Thorleifsson, G. ; Hagg, S.; Beekman, M.; Ladenvall, C.; Hottenga, J. -J.; Ried, J. S.; McCarthy, M. I.Morris, A.; Ripatti, S.; Prokopenko, I. (2013). Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S60.
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2013
Horikoshi, M.; Mägi, R.; Surakka, I.; Sarin, A. -P.; Mahajan, A.; Marullo, L.; Ferreira, T. ; Esko, T.; Lindgren, C. M.; Morris, A. P.; McCarthy, M. I.; Ripatti, S.; Prokopenko, I; ENGAGE, Consortium. (2013). Large-scale genome-wide association meta-analysis of the 1000 genomes project imputed data identifies novel susceptibility loci for glycaemic and obesity traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S61.
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2013
Horikoshi, Momoko; Magi, Reedik; Surakka, Ida; Sarin, Antti-Pekka; Mahajan, Anubha; Marullo, Letizia; Ferreira, Teresa; Esko, Tonu; Morris, Andrew P.; Mccarthy, Mark I.; Ripatti, Samuli; Prokopenko, Inga (2013). Large-Scale Genome-Wide Association Meta-Analysis using Imputation from the Dense 1000 Genomes Project Map Identifies Novel Susceptibility Loci for Glycemic and Obesity Traits. Diabetes, A83−A83.
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2013
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2013
Tõnisson, N.; Lokk, K; Modhukur, V.; Rajashekar, B; Martens, K; Koltšina, M; Mägi, R.; Kolde, R.; Salumets, A. (2013). DNA metylome comparison of various human tissues. European Journal of Human Genetics: European Human Genetics Conference; Pariis, Prantsusmaa; 8.–11. juuni, 2013. Nature Publishing Group, 373−373. (21; Suppl 2).
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2012
Chasman, DI.; Fuchsberger, C.; Pattaro, C.; Teumer, A.; Boger, CA.; Endlich, K.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Kottgen, A. (2012). Integration of Genome-Wide Association Studies with Biological Knowledge Identifies Six Novel Genes Related to Kidney Function. Human Molecular Genetics, 21 (24), 5329−5343. DOI: 10.1093/hmg/dds369.
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Nürnberg, ST.; Rendon, A.; Smethurst, PA.; Paul, DS.; Voss, K.; Thon, JN.; Lloyd-Jones, H.; Sambrook, JG.; Tijssen, MR.; Gieger, C.; Radhakrishnan, A.; Cvejic, A.; Tang, W.; Porcu, E.; Pistis, G.; Serbanovic-Canic, J.; Elling, U.; Goodall, AH.; Labrune, Y.; Lopez, LM. ... Ouwehand, W. (2012). A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood, 120 (24), 4859−4868. DOI: 10.1182/blood-2012-01-401893.
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Mägi, R; Asimit, JL; Day-Williams, AG; Zeggini, E; Morris, AP. (2012). Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases. Genetic Epidemiology, 36 (8), 785−796.10.1002/gepi.21675.
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Okada, Y; Sim, X; Go, MJ; Wu, JY; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, SC; Wong, TY; Liu, J; Young, TL; Aung, T; Seielstad, M; Teo, YY; Kim, YJ; Lee, JY; Han, BG ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904−909. DOI: 10.1038/ng.2352.
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2012
Yang, J; Loos, RJ; Powell, JE; Medland, SE; Speliotes, EK; Chasman, DI; Rose, LM; Thorleifsson, G; Steinthorsdottir, V; Mägi, R; Waite, L; Vernon, Smith, A; Yerges-Armstrong, LM; Monda, KL; Hadley, D; Mahajan, A; Li, G; Kapur, K; Vitart, V; Huffman, JE ... Visscher, PM (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature, 490 (7419), 267−272. DOI: 10.1038/nature11401.
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2012
Scott, RA.; Lagou, V.; Welch, RP.; Wheeler, E.; Montasser, ME.; Luan, J.; Mägi, R.; Strawbridge, RJ.; Rehnberg, E.; Gustafsson, S.; Kanoni, S.; Rasmussen-Torvik, LJ.; Yengo, L.; Lecoeur, C.; Shungin, D.; Sanna, S.; Sidore, C.; Johnson, PC.; Jukema, JW.; Johnson, T. ... Barroso, I. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991−1005. DOI: 10.1038/ng.2385.
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2012
Fox, Caroline S; Liu, Yongmei; White, Charles C; Feitosa, Mary; Smith, Albert V; Heard-Costa, Nancy; Lohman, Kurt; Johnson, Andrew D; Foster, Meredith C; Greenawalt, Danielle M; Griffin, Paula; Ding, Jinghong; Newman, Anne B; Tylavsky, Fran; Miljkovic, Iva; Kritchevsky, Stephen B; Launer, Lenore; Garcia, Melissa; Eiriksdottir, Gudny; Carr, J Jeffrey ... GLGC, Consortium. (2012). Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genetics, 8 (5), e1002695−e1002695.10.1371/journal.pgen.1002695.
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Ikram, MA.; Fornage, M.; Smith, AV.; Seshadri, S.; Schmidt, R.; Debette, S.; Vrooman, HA.; Sigurdsson, S.; Ropele, S.; Taal, HR.; Mook-Kanamori, DO.; Coker, LH.; Longstreth, WT.; Niessen, WJ.; DeStefano, AL.; Beiser, A.; Zijdenbos, AP.; Struchalin, M.; Jack, CR.; Rivadeneira, F. ... Wilson, JF. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5), 539−544.10.1038/ng.2245.
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Manning, AK.; Hivert, MF.; Scott, RA.; Grimsby, JL.; Bouatia-Naji, N.; Chen, H.; Rybin, D.; Liu, CT.; Bielak, LF.; Prokopenko, I.; Amin, N.; Barnes, D.; Cadby, G.; Hottenga, JJ.; Ingelsson, E.; Jackson, AU.; Johnson, T.; Kanoni, S.; Ladenvall, C.; Lagou, V. ... Langenberg, C. (2012). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44 (6), 659−669.10.1038/ng.2274.
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Bradfield, JP.; Taal, HR.; Timpson, NJ.; Scherag, A.; Lecoeur, C.; Warrington, NM.; Hypponen, E.; Holst, C.; Valcarcel, B.; Thiering, E.; Salem, RM.; Schumacher, FR.; Cousminer, DL.; Sleiman, PMA.; Zhao, JH.; Berkowitz, RI.; Vimaleswaran, KS.; Jarick, I.; Pennell, CE.; Evans, DM. ... Grant, SFA. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44 (5), 526−531.10.1038/ng.2247.
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Pattaro, C.; Köttgen, A.; Teumer, A.; Garnaas, M.; Boger, CA.; Fuchsberger, C.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Fox, CS. (2012). Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function. PLoS Genetics, 8 (3), e1002584−e1002584. DOI: 10.1371/journal.pgen.1002584.
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Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N ... Sladek, Robert (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLOS ONE, 7 (1), e29202−e29202.
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2012
Mägi, R; Morris, AP. (2012). Genome-wide association analysis of rare variants identifies potential novel susceptibility genes for type 1 diabetes and coronary artery disease. ANNALS OF HUMAN GENETICS, 76: European Mathematical Genetics Meeting, Gottingen, GERMANY, APR 12-13, 2012. Wiley-Blackwell, 421−422.
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Mägi, R; Horikoshi, M; Surakka, I; Wiltshire, S; Sarin, AP; Mahajan, A; Marullo, L; Ferreira, T; Hagg, S; Ried, JS; Winkler, T; Thorleifsson, G; Tsernikova, N; Esko, T; Willenborg, C; Nelson, CP; Beekman, M; Willems, SM; McCarthy, MI; Morris, AP ... Prokopenko, I. (2012). Large-scale Genome-wide Association Meta-analysis Using Imputation from 2188-haplotype 1000 Genomes Reference Panel Identifies Novel Susceptibility Loci for Anthropometric and Glycemic Traits. GENETIC EPIDEMIOLOGY, 36: Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Stevenson, WA, OCT 18-20, 2012. Wiley-Blackwell, 776−777. (7).
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Dimas, A.S.; Gomes, V.I.; Knowles, J.; Mägi, R.; Barker, A.; Hivert, M.-F.; Benazzo, A.; Rybin, D.; Assimes, T.I.; Ouertermous, T.; Walker, M.; Florez, J.C.; Barroso, I.; Langenberg, Cl.; Dupuis, J.; Watanabe, R.; McCarthy, M.; Ingelsson, E.; Prokopenko, I. (2012). Impact of Type 2 Diabetes Susceptibility Loci on Variation in Physiologic Glycaemic Traits in Non-Diabetic Individuals. Circulation, 126: AHA Scientific Session 2012, Los Angeles, USa, 3-7. Nov.. Lippincott Williams & Wilkins, 14977. (21).
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Bailey-Wilson, JE.; Brennan, JS.; Bull, SB.; Culverhouse, R.; Kim, Y.; Jiang, Y.; Jung, JS.; Li, Q.; Lamina, C.; Liu, Y.; Magi, R.; Niu, YS.; Simpson, CL.; Wang, LB.; Yilmaz, YE.; Zhang, HP.; Zhang, ZG. (2011). Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data. Genetic Epidemiology, 35, S92−S100.
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Chambers, JC; Zhang, WH; Sehmi, J; Li, XZ; Wass, MN; Van der Harst, P; Holm, H; Sanna, S; Kavousi, M; Baumeister, SE; Coin, LJ; Deng, GH; Gieger, C; Heard-Costa, NL; et, al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43 (11), 1131−1138. DOI: 10.1038/ng.970.
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Gieger, C; Radhakrishnan, A; Cvejic, A; Tang, WH; Porcu, E; Pistis, G; Serbanovic-Canic, J; Elling, U; Goodall, AH; Labrune, Y; Lopez, LM; Magi, R; Meacham, S; Okada, Y; Pirastu, N; Sorice, R; Teumer, A; Voss, K; Zhang, WH; Ramirez-Solis, R ... Soranzo, N (2011). New gene functions in megakaryopoiesis and platelet formation. Nature, 480 (7376), 201−208.
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Metspalu, M.; Romero, IG.; Yunusbayev, B.; Chaubey, G.; Mallick, CB.; Hudjashov, G.; Nelis, M.; Mägi, R.; Metspalu, E.; Remm, M.; Pitchappan, R.; Singh, L.; Thangaraj, K.; Villems, R.; Kivisild, T. (2011). Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia. The American Journal of Human Genetics, 89 (6), 731−44.10.1016/j.ajhg.2011.11.010.
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2011
Kilpelaeinen, Tuomas O.; den Hoed, Marcel; Ong, Ken K.; Grontved, Anders; Brage, Soren; Jameson, Karen; Cooper, Cyrus; Khaw, Kay-Tee; Ekelund, Ulf; Wareham, Nicholas J.; Loos, Ruth J. F. Early Growth Genetics Consortium, incl. Mägi R (2011). Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 (4), 851−860.10.3945/ajcn.110.000828.
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The International Consortium for Blood Pressure Genome-Wide Association Studies, incl. Sõber, S.; Snieder, H.; Org, E.; Veldre, G.; Viigimaa, M.; Laan, M. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478 (7367), 103−109. DOI: 10.1038/nature10405.
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Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Johnson, A.D.; Bochud, M.; Rice, K.M.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C. ... Metspalu, A. et al (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics, 43, 1005−1011. DOI: 10.1038/ng.922.
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Böger, CA; Chen, MH; Tin, A; Olden, M; Köttgen, A; de Boer, IH; Fuchsberger, C; O’Seaghdha, CM; Pattaro, C; Teumer, A; et, al. (2011). CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology, 22, 555−570.
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Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
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2011
Mägi, R.; Kumar, A.; Morris, AP. (2011). Assessing the impact of missing genotype data in rare variant association analysis. BMC Proceedings, 9 (5), S107−S107.
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2010
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Mägi, Reedik; Lindgren, Cecilia M.; Morris, Andrew P. (2010). Meta-analysis of sex-specific genome-wide association studies. Genetic Epidemiology, 34 (8), 846−853.10.1002/gepi.20540.
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Dupuis, J.; Langenberg, C.; Prokopenko, I.; Saxena, R.; Soranzo, N.; Jackson, A.U.; Wheeler, E.; Glazer, N.L.; Bouatia-Naji, N.; Gloyn, A.L.; Lindgren, C.M.; Mägi, R.; Morris, A.P.; Randall, J.; Johnson, T.; Elliott, P.; Rybin, D.; Thorleifsson, G.; Steinthorsdottir, V.; Henneman, P. ... Mitchell, B.D (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42 (2), 105−116.10.1038/ng.520.
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Mägi, R; Morris, AP. (2010). GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics, 11 (288), 288.10.1186/1471-2105-11-288.
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Ingelsson, E.; Langenberg, C.; Hivert, M.F.; Prokopenko, I.; Lyssenko, V.; Dupuis, J.; Mägi, R.; Sharp, S.; Jackson, A.U.; Assimes, T.L.; Shrader, P.; Knowles, J.W.; Zethelius, B.; Abbasi, F.A.; Bergman, R.N.; Bergmann, A.; Berne, C.; Boehnke, M.; Bonnycastle, L.L.; Bornstein, S.R. ... Florez, JC. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. DIABETES, 59: 59th Annual Meeting of the American-Society-of-Human-Genetics; Honolulu, HI, USA; OCT 20-24, 2009. 1266−1275. (5).10.2337/db09-1568.
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Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; et, al.; Mägi, R.; et, al. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42 (5), 376−384.10.1038/ng.568.
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Mägi, R.; Hottenga, J. J.; Prokopenko, I. (2010). A genome-wide association analysis of over 75,000 individuals identifies gender-specific effects for fasting glycaemic traits. Diabetologia, 53: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, SWEDEN, SEP 20-24, 2010. Springer, S28−S28.
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Mägi, R; Morris, AP. (2010). GRANVIL: Rare Variant Analysis of Genome-Wide Association Studies. Genetic Epidemiology, 34: 19th Annual Meeting of the International-Genetic-Epidemiology-Society, Boston, MA, OCT 10-12, 2010. Wiley-Blackwell, 926−926. (8).
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Kuningas, M.; Mägi, R.; Westendorp, R.G.; Slagboom, P.E.; Remm, M.; van Heemst, D. (2007). Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. European Journal of Human Genetics, 15 (3), 294−301. DOI: 10.1038/sj.ejhg.5201766.
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Kaminski, S.; Brym, P.; Rusc, A.; Wojcik, E.; Ahman, A.; Mägi, R. (2006). Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (APEX) microarray. Animal biotechnology, 17 (1), 1−11.
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Montpetit, A.; Nelis, M.; Laflamme, P.; Magi, R.; Ke, X.Y.; Remm, M.; Cardon, L.; Hudson, T.J.; Metspalu, A. (2006). An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. PLoS Genetics, 2 (3), 282−290.
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Mägi, R.; Kaplinski, L.; Remm, M. (2006). The Whole Genome TagSNP Selection and Transferability Among HapMap Populations. Pacific Symposium on Biocomputing 2006: 2006. World Scientific Publ Co Pte Ltd, 535−543.
1.1.
2005
Mueller, J. C.; Lõhmussaar, E.; Mägi, R.; Remm, M.; Bettecken, T.; Lichtner, P.; Huber, S.; Illig, T; Luedemann, J.; Schreiber, S.; Wichmann, H. E.; Pramstaller, P.; Romeo, G.; Testa, A.; Metspalu, A.; Meitinger, T. (2005). Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations. The American Journal of Human Genetics, 76 (3), 387−398.
1.1.
2002
Liira, J.; Zobel, K.; Magi, R.; Molenberghs, G. (2002). Vertical structure of herbaceous canopies: the importance of plant growth-form and species-specific traits. Plant Ecology, 163 (1), 123−134.
1.1.
2002
Dawson, E.; Abecasis, GR.; Bumpstead, S.; Chen, Y.; Hunt, S.; Beare, DM.; Pabial, J.; Dibling, T.; Tinsley, E.; Kirby, S.; Carter, D.; Papaspyridonos, M.; Livingstone, S.; Ganske, R.; Lohmmussaar, E.; Zernant, J.; Tonisson, N.; Remm, M.; Magi, R.; Puurand, T. ... Dunham, I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature, 418 (6897), 544−548.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using APEX arrays. European Journal of Human Genetics, 10, 299−299.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Puurano, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using Arrayed Primer EXtension (APEX) technology. The American Journal of Human Genetics, 71 (4), 449−449.
5.1.
2001
Metspalu, A.; Zernant, J.; Lohmussaar, E.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, L.; Pavel, H.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M. (2001). SNP analysis of the human chromosome 22 using APEX arrays. The American Journal of Human Genetics, 69 (4), 408−408.

Tööstusomand

29.12.2020

Reedik Mägi

https://www.etis.ee/CV/Reedik_Mägi/eng
18.08.1978
737 4045
reedik.magi@ut.ee

Career

Institutions and positions
01.01.2021–...   
University of Tartu, Faculty of Science and Technology, Institute of Genomics, Professor in Bioinformatics (1,00)
19.08.2019–31.12.2020   
University of Tartu, Institute of Genomics, Research Professor in Bioinformatics (1,00)
01.01.2018–18.08.2019   
University of Tartu, Institute of Genomics, Senior Research Fellow in Bioinformatics (1,00)
01.09.2016–31.12.2017   
University of Tartu, Estonian Genome Center , Senior Research Fellow in Bioinformatics (1,00)
01.09.2011–31.08.2016   
University of Tartu, Estonian Genome Center , Senior Research Fellow (1,00)
01.02.2010–31.08.2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow (0,10)
2009–2011   
University Of Oxford, Marie Curie Research Fellow in Wellcome Trust Centre for Human Genetics (1,00)
01.09.2008–31.08.2011   
Estonian Biocentre, Extraordinary Researcher (0,10)
01.04.2008–31.01.2010   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow extraordinarius (0,10)
2008–2011   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Chair of Bioinformatics, Extraordinary Researcher (0,10)
2008–2009   
University Of Oxford, Senior Statistical Geneticist (1,00)
01.01.2008–31.12.2011   
Wellcome Trust Centre for Human Genetics, University of Oxford; postdoc
01.01.2008–31.03.2008   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Research Fellow extraordinarius (1,00)
01.12.2007–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.08.2007–30.11.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,10)
01.02.2007–31.07.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.09.2006–31.01.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.07.2006–31.08.2006   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.09.2005–30.06.2006   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.07.2005–31.08.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
01.02.2005–30.06.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (0,50)
01.02.2004–31.01.2005   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Research Fellow extraordinarius (1,00)
2004–2008   
University of Tartu, University of Tartu, scientist (0,50)
01.01.2002–2004   
Biodata Ltd, Biodata Ltd., IT specialist (0,50)
01.01.2000–31.12.2002   
Asper Biotech Ltd., IT specialist
 
 
Education
2003–2007   
University of Tartu, PhD stud. of bioinformatics
2000–2003   
University of Tartu, MSc of plant ecology
1996–2000   
University of Tartu, BS of botany and ecology
 
 
R&D related managerial and administrative work
2016−...   
Co-leader of annual "Introduction to the statistical analysis of genome-wide association studies" course in Imperial College of London, UK
2017−2017   
Organizer and the member of scientific committee of of "European Mathematical Genetics Meeting"

Qualifications

Academic degrees
Reedik Mägi, Doctor's Degree, 2007, (sup) Maido Remm, The Linkage Disequilibrium And The Selection of Genetic markers For Association Studies in European Populations, University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology.
Reedik Mägi, Research Master's Degree, 2003, (sup) Kristjan Zobel, Rohu- ja puhmarinde võra struktuur 27 Eesti niidu- ja metsakoosluses, University of Tartu, Faculty of Biology and Geography, Institute of Botany and Ecology.
 
 
Honours & awards
2019, Reedik Mägi, National Science Award in chemistry and molecular biology for the series of works "Basic research on genetics and genomics for the implementation of personal medicine in Estonia" (Esko, Mägi, Fischer, Milani)
2009, Reedik Mägi, EC FP7 Marie Curie IEF (2009-2011)
2008, Reedik Mägi, Post-doctoral fellowship from Estonian Biocentre (ECOGENE)
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.1. Biomedicine; CERCS CLASSIFICATION: B100 History and philosophy of biomedical sciences, theoretical biology, general aspects of evolution ; SPECIFICATION: Main scientific interests include population and statistical genetics, as well as software development for implementing statistical methods for genetic studies. I have worked on the development and implementation of methodology of meta-analysis, rare-variant analysis, and sequencing data analysis. I am also participating in several association studies, which are mainly related to T2D and various anthropometric phenotypes.
 
 

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2020
Marees, Andries T.; Gamazon, Eric R.; Gerring, Zachary; Vorspan, Florence; Fingal, Josh; van den Brink, Wim; Smit, Dirk J. A.; Verweij, Karin J. H.; Kranzler, Henry R.; Sherva, Richard; Farrer, Lindsay; Stringer, Sven; Minica, Camelia C.; Mbarek, Hamdi; Bernard, Manon; Derringer, Jaime; van Eijk, Kristel R.; Isen, Joshua D.; Loukola, Anu; Maciejewski, Dominique F. ... Derks, Eske M. (2020). Post-GWAS analysis of six substance use traits improves the identification and functional interpretation of genetic risk loci. Drug and Alcohol Dependence, 206, ARTN 107703. DOI: 10.1016/j.drugalcdep.2019.107703.
1.1.
2020
Li C, Stoma S, Lotta LA, Warner S, Albrecht E, et al. (2020). Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length. The American Journal of Human Genetics , 106 (3), 389−404. DOI: 10.1016/j.ajhg.2020.02.006.
1.1.
2020
Pankratov, Vasili; Montinaro, Francesco; Kushniarevich, Alena; Hudjashov, Georgi; Jay, Flora; Saag, Lauri; Flores, Rodrigo; Marnetto, Davide; Seppel, Marten; Kals, Mart; Vosa, Urmo; Taccioli, Cristian; Mols, Mart; Milani, Lili; Aasa, Anto; Lawson, Daniel John; Esko, Tonu; Magi, Reedik; Pagani, Luca; Metspalu, Andres ... Metspalu, Mait (2020). Differences in local population history at the finest level: the case of the Estonian population. European Journal of Human Genetics, 28, 11, 1580−1591. DOI: 10.1038/s41431-020-0699-4.
1.1.
2020
Orthofer, Michael; Valsesia, Armand; Maegi, Reedik; Wang, Qiao-Ping; Kaczanowska, Joanna; Kozieradzki, Ivona; Leopoldi, Alexandra; Cikes, Domagoj; Zopf, Lydia M.; Tretiakov, Evgenii O.; Demetz, Egon; Hilbe, Richard; Boehm, Anna; Ticevic, Melita; Noukas, Margit; Jais, Alexander; Spirk, Katrin; Clark, Teleri; Amann, Sabine; Lepamets, Maarja ... Penninger, Josef M. (2020). Identification of ALK in Thinness. Cell, 181 (6), 1246−1285. DOI: 10.1016/j.cell.2020.04.034.
1.1.
2020
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei ... Fornage, Myriam (2020). Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry. DOI: 10.1038/s41380-020-0719-3.
1.1.
2020
Marnetto, Davide; Pärna, Katri; Läll, Kristi; Molinaro, Ludovica; Montinaro, Francesco; Haller, Toomas; Metspalu, Mait; Mägi, Reedik; Fischer, Krista; Pagani, Luca (2020). Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals. Nature Communications, 11 (1), 1628−1628. DOI: 10.1038/s41467-020-15464-w.
1.1.
2020
Bovijn, Jonas; Krebs, Kristi; Chen, Chia-Yen; Boxall, Ruth; Censin, Jenny C; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Laber, Samantha; Millwood, Iona Y; Lin, Kuang; Li, Liming; Chen, Zhengming; Milani, Lili; Smith, George Davey; Walters, Robin G; Mägi, Reedik; Neale, Benjamin M; Lindgren, Cecilia M; Holmes, Michael V (2020). Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics. Science Translational Medicine, 12 (549). DOI: 10.1126/scitranslmed.aay6570.
1.1.
2020
Joo, YY; Actkins, K; Pacheco, JA; Basile, AO; Carroll, R; Crosslin, DR; Day, F; Denny, JC; Velez Edwards, DR; Hakonarson, H; Harley, JB; Hebbring, SJ; Ho, K; Jarvik, GP; Jones, M; Karaderi, T; Mentch, FD; Meun, C; Namjou, B; Pendergrass, S ... International PCOS Consortium (including A Salumets) (2020). A Polygenic and Phenotypic Risk Prediction for Polycystic Ovary Syndrome Evaluated by Phenome-Wide Association Studies. Journal of Clinical Endocrinology and Metabolism, 105 (6), dgz326. DOI: 10.1210/clinem/dgz326.
1.1.
2020
Guo, Yanjun; Rist, Pamela M.; Daghlas, Iyas; Giulianini, Franco; International Headache Genetics Consortium; 23andMe Research Team; Kurth, Tobias; Chasman, Daniel, I (2020). A genome-wide cross-phenotype meta-analysis of the association of blood pressure with migraine. Nature Communications, 11 (1), ARTN 3368. DOI: 10.1038/s41467-020-17002-0.
1.1.
2020
Krebs, Kristi; Bovijn, Jonas; Zheng, Neil; Lepamets, Maarja; Censin, Jenny C; Jürgenson, Tuuli; Särg, Dage; Abner, Erik; Laisk, Triin; Luo, Yang; Skotte, Line; Geller, Frank; Feenstra, Bjarke; Wang, Wei; Auton, Adam; ,; Raychaudhuri, Soumya; Esko, Tõnu; Metspalu, Andres; Laur, Sven ... Fadista, João (2020). Genome-wide Study Identifies Association between HLA-B∗55:01 and Self-Reported Penicillin Allergy. The American Journal of Human Genetics, 107 (4), 612−621. DOI: 10.1016/j.ajhg.2020.08.008.
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F.; Feufer, Arne P.; Marullo, Letizia; Magi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in Medicine, 13 (11), 931−940.10.2217/bmm-2017-0431.
1.1.
2019
Alver, Maris; Palover, Marili; Saar, Aet; Läll, Kristi; Zekavat, Seyedeh Maryam; Tõnisson, Neeme; Leitsalu, Liis; Reigo, Anu; Nikopensius, Tiit; Ainla, Tiia; Kals, Mart; Mägi, Reedik; Gabriel, Stacey B; Eha, Jaan; Lander, Eric S; Irs, Alar; Philippakis, Anthony; Marandi, Toomas; Natarajan, Pradeep; Metspalu, Andres ... Esko, Tõnu (2019). Recall by genotype and cascade screening for familial hypercholesterolemia in a population-based biobank from Estonia. Genetics in Medicine, 21 (5), 1−8. DOI: 10.1038/s41436-018-0311-2.
1.1.
2019
Reisberg, Sulev; Galwey, Nicholas; Avillach, Paul; Sahlqvist, Anna-Stina; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Vilo, Jaak; James, Glen (2019). Comparison of variation in frequency for SNPs associated with asthma or liver disease between Estonia, HapMap populations and the 1000 genome project populations. International Journal of Immunogenetics, 46 (1), 1−10. DOI: 10.1111/iji.12413.
1.1.
2019
Tasa, T,; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 442−454. DOI: 10.1038/s41431-018-0300-6.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, 12 (5), 1050−1061.10.1111/eva.12780.
1.1.
2019
de Vries, Paul S.; Brown, Michael R.; Bentley, Amy R.; Sung, Yun J.; Winkler, Thomas W.; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T.; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E.; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Richard, Melissa A.; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C. (2019). Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology, 188 (6), 1033−1054. DOI: 10.1093/aje/kwz005.
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648. DOI: 10.1038/s41588-019-0378-y.
1.1.
2019
Saag, Lehti; Laneman, Margot; Varul, Liivi; Malve, Martin; Valk, Heiki; Razzak, Maria A.; Shirobokov, Ivan G.; Khartanovich, Valeri I.; Mikhaylova, Elena R.; Kushniarevich, Alena; Scheib, Christiana Lyn; Solnik, Anu; Reisberg, Tuuli; Parik, Juri; Saag, Lauri; Metspalu, Ene; Rootsi, Siiri; Montinaro, Francesco; Remm, Maido; Magi, Reedik ... Tambets, Kristiina (2019). The Arrival of Siberian Ancestry Connecting the Eastern Baltic to Uralic Speakers further East. Current Biology, 29 (10), 1701−1728.10.1016/j.cub.2019.04.026.
1.1.
2019
Justice, Anne E; Karaderi, Tugce; Highland, Heather M; Young, Kristin L; Graff, Mariaelisa; Lu, Yingchang; Turcot, Valérie; Auer, Paul L; Fine, Rebecca S; Guo, Xiuqing; Schurmann, Claudia; Lempradl, Adelheid; Marouli, Eirini; Mahajan, Anubha; Winkler, Thomas W; Locke, Adam E; Medina-Gomez, Carolina; Esko, Tõnu; Vedantam, Sailaja; Giri, Ayush ... Lindgren, Cecilia M (2019). Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics, 51 (3), 452−469.10.1038/s41588-018-0334-2.
1.1.
2019
Liu, Mengzhen; Jiang, Yu; Wedow, Robbee; Li, Yue; Brazel, David M; Chen, Fang; Datta, Gargi; Davila-Velderrain, Jose; McGuire, Daniel; Tian, Chao; Zhan, Xiaowei; ,; ,; Choquet, Hélène; Docherty, Anna R; Faul, Jessica D; Foerster, Johanna R; Fritsche, Lars G; Gabrielsen, Maiken Elvestad; Gordon, Scott D ... Vrieze, Scott (2019). Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. Nature Genetics, 51 (2), 237−248. DOI: 10.1038/s41588-018-0307-5.
1.1.
2019
Bovijn, Jonas; Jackson, Leigh; Censin, Jenny; Chen, Chia-Yen; Laisk, Triin; Laber, Samantha; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Smoller, Jordan W; Harrison, Jamie W; Ruth, Katherine S; Beaumont, Robin N; Jones, Samuel E; Tyrrell, Jessica; Wood, Andrew R; Weedon, Michael N; Mägi, Reedik; Neale, Benjamin; Lindgren, Cecilia M ... Holmes, Michael V (2019). GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology. The American Journal of Human Genetics, 104 (1), 157−163.10.1016/j.ajhg.2018.11.004.
1.1.
2019
Wiberg, Akira; Ng, Michael; Schmid, Annina B.; Smillie, Robert W.; Baskozos, Georgios; Holmes, Michael V.; Kunnapuu, K.; Magi, R.; Bennett, David L.; Furniss, Dominic (2019). A genome-wide association analysis identifies 16 novel susceptibility loci for carpal tunnel syndrome. Nature Communications, 10, ARTN 1030.10.1038/s41467-019-08993-6.
1.1.
2019
James, Glen; Reisberg, Sulev; Lepik, Kaido; Galwey, Nicholas; Avillach, Paul; Kolberg, Liis; Mägi, Reedik; Esko, Tõnu; Alexander, Myriam; Waterworth, Dawn; Loomis, A. Katrina; Vilo, Jaak (2019). An exploratory phenome wide association study linking asthma and liver disease genetic variants to electronic health records from the Estonian Biobank. PLoS ONE, 14 (4), ARTN e0215026. DOI: 10.1371/journal.pone.0215026.
1.1.
2019
Wuttke, Matthias; Li, Yong; Li, Man; Sieber, Karsten B.; Feitosa, Mary F.; Gorski, Mathias; Tin, Adrienne; Wang, Lihua; Chu, Audrey Y.; Hoppmann, Anselm; Kirsten, Holger; Giri, Ayush; Chai, Jin-Fang; Sveinbjornsson, Gardar; Tayo, Bamidele O.; Nutile, Teresa; Fuchsberger, Christian; Marten, Jonathan; Cocca, Massimiliano; Ghasemi, Sahar ... Pattaro, Cristian (2019). A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nature Genetics, 51 (6), 957−976. DOI: 10.1038/s41588-019-0407-x.
1.1.
2019
Deng, Wei Q.; Mao, Shihong; Kalnapenkis, Anette; Esko, Tonu; Magi, Reedik; Pare, Guillaume; Sun, Lei (2019). Analytical strategies to include the X-chromosome in variance heterogeneity analyses: Evidence for trait-specific polygenic variance structure. Genetic Epidemiology. DOI: 10.1002/gepi.22247.
1.1.
2019
Tin, Adrienne; Marten, Jonathan; Kuhns, Victoria L. Halperin; Li, Yong; Wuttke, Matthias; Kirsten, Holger; Sieber, Karsten B.; Qiu, Chengxiang; Gorski, Mathias; Yu, Zhi; Giri, Ayush; Sveinbjornsson, Gardar; Li, Man; Chu, Audrey Y.; Hoppmann, Anselm; O'Connor, Luke J.; Prins, Bram; Nutile, Teresa; Noce, Damia; Akiyama, Masato ... Koettgen, Anna (2019). Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. Nature Genetics, 51 (10), 1459−1478. DOI: 10.1038/s41588-019-0504-x.
1.1.
2019
Linner, Richard Karlsson; Biroli, Pietro; Kong, Edward; Meddens, Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Mael; Tino, Stephen P.; Abdellaoui, Abdel; Hammerschlag, Anke R.; Nivard, Michel G.; Okbay, Aysu; Rietveld, Cornelius A.; Timshel, Pascal N.; Trzaskowski, Maciej; de Vlaming, Ronald; Zund, Christian L.; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H. ... Beauchamp, Jonathan P. (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 (2), 245−261. DOI: 10.1038/s41588-018-0309-3.
5.1.
2019
Lepamets, Maarja; Lepik, Kaido; Kutalik, Zoltàn; Mägi, Reedik (2019). Genome-wide copy number variant association study reveals several novel disease-associated loci. European Journal of Human Genetics, 27: 52nd Conference of the European Society of Human Genetics (ESHG); Gothenburg, Sweden; June 15-18, 2019. Nature Publishing Group, 1114−1114.
5.1.
2019
Bovijn J., Krebs K., Chen C., Boxall R., Censin JC., Ferreira T., Pulit SL., Glastonbury CA., Laber S., Millwood IY., Lin K., Li L., Chen Z., Milani L., Walters RG., Mägi R., Neale BM., Lindgren CM., Holmes MV. (2019). Lifelong genetically lowered sclerostin and risk of cardiovascular disease. Eur J Hum Genet, 27: Abstracts from the 52nd European Society of Human Genetics (ESHG) Conference: Oral Presentations.. Nature, 1120−1121. (10; S2).
5.2.
2019
Eltermaa, Mall; Jakobson, Maili; Utt, Meeme; Kõks, Sulev; Mägi, Reedik; Starkopf, Joel (2019). Geneetilistel variantidel humaniini nukleaarsete isovormide geenides ei ole statistiliselt olulist seost koronaararteri haigusega. Eesti Arst, 98. OÜ Celsius Healthcare, 36−36.
6.7.
2019
Kals, Mart; Nikopensius, Tiit; Läll, Kristi; Pärn, Kalle; Tõnis Sikka, Timo; Suvisaari, Jaana; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Metspalu, Andres; Esko, Tõnu; Palta, Priit; Mägi, Reedik; (2019). Advantages of genotype imputation with ethnically matched reference panel for rare variant association analyses. bioRxiv, 579201. DOI: 10.1101/579201.
6.7.
2019
Männik, Katrin; Arbogast, Thomas; Lepamets, Maarja; Lepik, Kaido; Pellaz, Anna; Ademi, Herta; Kupchinsky, Zachary A; Ellegood, Jacob; Attanasio, Catia; Messina, Andrea; Rotman, Samuel; Martin-Brevet, Sandra; Dubruc, Estelle; Chrast, Jacqueline; Lerch, Jason P; Qiu, Lily R; Laisk, Triin; The 16p11.2 European Consortium; The Simons VIP Consortium; The eQTLGen Consortium ... Reymond, Alexandre (2019). Leveraging biobank-scale rare and common variant analyses to identify ASPHD1 as the main driver of reproductive traits in the 16p11.2 locus. bioRxiv. DOI: 10.1101/716415.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. The American Journal of Human Genetics, 102 (3), 375−400. DOI: 10.1016/j.ajhg.2018.01.015.
1.1.
2018
Pervjakova, N.; Kukushkina, V.; Haller, T.; Kasela, S.; Joensuu, A.; Kristiansson, K.; Annilo, T.; Perola, M.; Salomaa, V.; Jousilahti, P.; Metspalu, A.; Magi, R. (2018). Genome-wide analysis of nuclear magnetic resonance metabolites revealed parent-of-origin effect on triglycerides in medium very low-density lipoprotein in PTPRD gene. Biomarkers in Medicine, 12 (5), 439−446. DOI: 10.2217/bmm-2018-0020.
1.1.
2018
Suhorutshenko, Marina; Kukushkina, Viktorija; Velthut-Meikas, Agne; Altmäe, Signe; Peters, Maire; Mägi, Reedik; Krjutškov, Kaarel; Koel, Mariann; Codoñer, Francisco; Martinez-Blanch, Juan; Vilella, Felipe; Simón, Carlos; Salumets, Andres; Laisk, Triin (2018). Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity. Human Reproduction, 33 (11), 2074−2086. DOI: 10.1093/humrep/dey301.
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Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13 (6), e0198166−e0198166. DOI: 10.1371/journal.pone.0198166.
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Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121. DOI: 10.1038/s41588-018-0147-3.
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Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. The Journal of Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
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Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516. DOI: 10.1038/s41588-018-0241-6.
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Pasman, Joëlle A; Verweij, Karin J H; Gerring, Zachary; Stringer, Sven; Sanchez-Roige, Sandra; Treur, Jorien L; Abdellaoui, Abdel; Nivard, Michel G; Baselmans, Bart M L; Ong, Jue-Sheng; Ip, Hill F; van der Zee, Matthijs D; Bartels, Meike; Day, Felix R; Fontanillas, Pierre; Elson, Sarah L; ,; de Wit, Harriet; Davis, Lea K; MacKillop, James ... Vink, Jacqueline M (2018). GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia. Nature Neuroscience, 21 (9), 1161−1170.10.1038/s41593-018-0206-1.
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Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429. DOI: 10.1038/s41588-018-0205-x.
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Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571. DOI: 10.1038/s41588-018-0084-1.
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Vals, Mari-Anne; Pajusalu, Sander; Kals, Mart; Magi, Reedik; Ounap, Katrin (2018). The Prevalence of PMM2-CDG in Estonia Based on Population Carrier Frequencies and Diagnosed Patients. In: JIMD REPORTS, VOL 39 (13−17).06.07.2017 BERLIN: SPRINGER-VERLAG BERLIN. (39).10.1007/8904_2017_41.
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Lepamets, Maarja; Lepik, Kaido; Kals, Mart; Carmeli, Cristian; Claringbould, Annique; Bochud, Murielle; Stringhini, Silvia; Wijmenga, Cisca; Franke, Lude; Mägi, Reedik; Kutalik, Zoltàn (2018). New Quality Measure for CNV: A Multi-Omics Approach. Human Heredity, 83: 46th European Mathematical Genetics Meeting (EMGM); Cagliari, Italy; April 18-20, 2018. Karger, 16−16.
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Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez ... McCarthy, Mark I (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5, 180002−180002. DOI: 10.1038/sdata.2018.2.
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2017
Huan, Tianxiao; Joehanes, Roby; Schurmann, Claudia; Schramm, Katharina; Pilling, Luke C; Peters, Marjolein J; Mägi, Reedik; DeMeo, Dawn; O'Connor, George T; Ferrucci, Luigi; Teumer, Alexander; Homuth, Georg; Biffar, Reiner; Völker, Uwe; Herder, Christian; Waldenberger, Melanie; Peters, Annette; Zeilinger, Sonja; Metspalu, Andres; Hofman, Albert ... Levy, Daniel (2017). A Whole-Blood Transcriptome Meta-Analysis Identifies Gene Expression Signatures of Cigarette Smoking. Human Molecular Genetics, 25 (21), 1−33. DOI: 10.1093/hmg/ddw288.
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Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201. DOI: 10.1038/mp.2016.71.
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Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences, 114 (3), E327−E336. DOI: 10.1073/pnas.1619052114.
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Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Ehret, Georg B. (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nature Genetics, 3, 403−415. DOI: 10.1038/ng.3768.
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Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110. DOI: 10.1186/s12859-017-1530-2.
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Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25.10.1186/s12859-016-1437-3.
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R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical Pharmacology & Therapeutics, 101 (5), 684−695. DOI: 10.1002/cpt.540.
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Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186. DOI: 10.1038/ng.3912.
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Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genetics, 13 (6), e1006812. DOI: 10.1371/journal.pgen.1006812.
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Kukushkina, Viktorija; Modhukur, Vijayachitra; Suhorutsenko, Marina; Peters, Maire; Magi, Reedik; Rahmioglu, Nilufer; Velthut-Meikas, Agne; Altmae, Signe; Esteban, Francisco J.; Vilo, Jaak; Zondervan, Krina; Salumets, Andres; Laisk-Podar, Triin (2017). DNA methylation changes in endometrium and correlation with gene expression during the transition from pre-receptive to receptive phase. Scientific Reports, 7, ARTN 3916. DOI: 10.1038/s41598-017-03682-0.
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2017
Eichstaedt, Christina A; Pagani, Luca; Antao, Tiago; Inchley, Charlotte E; Cardona, Alexia; Mörseburg, Alexander; Clemente, Florian J; Sluckin, Timothy J; Metspalu, Ene; Mitt, Mario; Mägi, Reedik; Hudjashov, Georgi; Metspalu, Mait; Mormina, Maru; Jacobs, Guy S; Kivisild, Toomas (2017). Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations. Scientific Reports, 7 (1), 13042−13042.10.1038/s41598-017-13382-4.
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Kraja, Aldi T.; Cook, James P.; Warren, Helen R.; Surendran, Praveen; Liu, Chunyu; Evangelou, Evangelos; Manning, Alisa K.; Grarup, Niels; Drenos, Fotios; Sim, Xueling; Smith, Albert Vernon; Amin, Najaf; Blakemore, Alexandra I. F.; Bork-Jensen, Jette; Brandslund, Ivan; Farmaki, Aliki-Eleni; Fava, Cristiano; Ferreira, Teresa; Herzig, Karl-Heinz; Giri, Ayush ... Howson, Joanna M. M. (2017). New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals. Circulation Cardiovascular Genetics, 10 (5), UNSP e001778.10.1161/CIRCGENETICS.117.001778.
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Mägi, R; Horikoshi, M; Sofer, T; Mahajan, A; Kitajima, H; Franceschini, N; McCarthy, MI; COGENT-Kidney, Consortium; T2D-GENES, Consortium; Morris, AP (2017). Trans-ethnic meta-regression of genome-wide association studies accounting for ancestry increases power for discovery and improves fine-mapping resolution. Human Molecular Genetics, 26 (18), 3639−3650.10.1093/hmg/ddx280.
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Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N. William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez ... McCarthy, Mark I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, ARTN 170179. DOI: 10.1038/sdata.2017.179.
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Liu, Dajiang J.; Peloso, Gina M.; Yu, Haojie; Butterworth, Adam S.; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish; Emdin, Connor; Alam, Dewan; Alves, Alexessander Couto; Amouyel, Philippe; Di Angelantonio, Emanuele; Arveiler, Dominique; Assimes, Themistocles L.; Auer, Paul L.; Baber, Usman; Ballantyne, Christie M.; Bang, Lia E.; Benn, Marianne; Bis, Joshua C. ... Kathiresan, Sekar (2017). Exome-wide association study of plasma lipids in > 300,000 individuals. Nature Genetics, 49 (12), 1758−1772. DOI: 10.1038/ng.3977.
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Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994.10.1038/ejhg.2017.90.
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Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung ... Lindgren, Cecilia M. (2017). A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 66 (7), 2019−2032. DOI: 10.2337/db16-1329.
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Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845. DOI: 10.1038/ng.3841.
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Graff, Mariaelisa; Scott, Robert A.; Justice, Anne E.; Young, Kristin L.; Feitosa, Mary F.; Barata, Llilda; Winkler, Thomas W.; Chu, Audrey Y.; Mahajan, Anubha; Hadley, David; Xue, Luting; Workalemahu, Tsegaselassie; Heard-Costa, Nancy L.; den Hoed, Marcel; Ahluwalia, Tarunveer S.; Qi, Qibin; Ngwa, Julius S.; Renstrom, Frida; Quaye, Lydia; Eicher, John D. ... Kilpelainen, Tuomas O. (2017). Genome-wide physical activity interactions in adiposity. A meta-analysis of 200,452 adults. PLoS Genetics, 13 (4), ARTN e1006528. DOI: 10.1371/journal.pgen.1006528.
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Scott, Robert A.; Scott, Laura J.; Maegi, Reedik; Marullo, Letizia; Gaulton, Kyle J.; Kaakinen, Marika; Pervjakova, Natalia; Pers, Tune H.; Johnson, Andrew D.; Eicher, John D.; Jackson, Anne U.; Ferreira, Teresa; Lee, Yeji; Ma, Clement; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Qi, Lu; Van Zuydam, Natalie R.; Mahajan, Anubha; Chen, Han ... Prokopenko, Inga (2017). An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes, 66 (11), 2888−2902. DOI: 10.2337/db16-1253.
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Mitt, Mario; Kals, Mart; Parn, Kalle; Gabriel, Stacey B; Lander, Eric S; Palotie, Aarno; Ripatti, Samuli; Morris, Andrew P; Metspalu, Andres; Esko, Tonu; Magi, Reedik; Palta, Priit; (2017). Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel. European Journal of Human Genetics, 25 (7), 869−879. DOI: 10.1038/ejhg.2017.51.
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Rahmioglu, Nilufer; Lockstone, Helen; Ferreira, Teresa; Magi, Reedik; Van De Bunt, Martijn; Lindgren, Cecilia; Morris, Andrew; Becker, Christian; Zondervan, Krina (2017). Large-Scale Integrated Genome-Wide RNA Sequencing, miRNA Array, and Genomic Analyses to Unravel the Functionality of Genome-Wide Association Results in Endometriosis. Reproductive Sciences, 24, 205A−206A.
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Kaakinen, Marika; Magi, Reedik; Lagou, Vasiliki; Claringbould, Annique; Gaulton, Kyle; Fischer, Krista; Morris, Andrew; Prokopenko, Inga (2017). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. Genetic Epidemiology, 41 (7), 652−653.
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Suhorutshenko, M.; Kukushkina, V.; Velthut-Meikas, A.; Altmae, S.; Maire, P.; Magi, R.; Codoner, F.; Vilella, F.; Simon, C.; Salumets, A.; Laisk-Podar, T. (2017). Transcriptomic profile of early and mid-secretory endometrium revealed by RNA-seq: a paired sample cohort study. FEBS Journal, 284, 134−134.
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Teumer, A.; Qi, Q.; Nethander, M.; Aschard, H.; Bandinelli, S.; Beekman, M.; Berndt, S. I.; Bidlingmaier, M.; Broer, L.; Cappola, A.; Ceda, G. P.; Chanock, S.; Chen, M. -H.; Chen, T. C.; Chen, Y. -D. I.; Chung, J.; Miglianico, Del Greco F.; Eriksson, J.; Ferrucci, L.; Friedrich, N. ... Kaplan, R. C. (2017). Genomewide meta-analysis identifies loci associated with IGF-I and IGEBP-3 levels with impact on age-related traits (vol 15, pg 811, 2016). Aging Cell, 16 (4), 898−898. DOI: 10.1111/acel.12612.
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Warren, Helen R.; Evangelou, Evangelos; Cabrera, Claudia P.; Gao, He; Ren, Meixia; Mifsud, Borbala; Ntalla, Ioanna; Surendran, Praveen; Liu, Chunyu; Cook, James P.; Kraja, Aldi T.; Drenos, Fotios; Loh, Marie; Verweij, Niek; Marten, Jonathan; Karaman, Ibrahim; Lepe, Marcelo P. Segura; O'Reilly, Paul F.; Knight, Joanne; Snieder, Harold ... Elliott, Paul (2017). Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk (vol 49, pg 403, 2017). Nature Genetics, 49 (10), 1558−1558. DOI: 10.1038/ng1017-1558a.
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Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroula ... Loos, Ruth J F (2016). New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. Nature Communications, 7, 10495−10495.10.1038/ncomms10495.
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Hägg, S; Fall, T; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Kals, M; de Vries, PS; Dehghan, A; Willems, SM; Sarin, AP; Kristiansson, K; Nuotio, ML; Havulinna, AS; de Bruijn, RF; Ikram, MA; Kuningas, M; Stricker, BH; Franco, OH; Benyamin, B ... European, Network, for, Genetic, and, Genomic, Epidemiology, (ENGAGE) consortium. (2015). Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. International Journal of Epidemiology, 44 (2), 578−586. DOI: 10.1093/ije/dyv094.
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2015
Day, Felix R; Ruth, Katherine S; Thompson, Deborah J; Lunetta, Kathryn L; Pervjakova, Natalia; Chasman, Daniel I; Stolk, Lisette; Finucane, Hilary K; Sulem, Patrick; Bulik-Sullivan, Brendan; Esko, Tõnu; Johnson, Andrew D; Elks, Cathy E; Franceschini, Nora; He, Chunyan; Altmaier, Elisabeth; Brody, Jennifer A; Franke, Lude L; Huffman, Jennifer E; Keller, Margaux F ... Murray, Anna (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47 (11), 1294−303. DOI: 10.1038/ng.3412.
1.1.
2015
Männik, Katrin; Mägi, Reedik; Macé, Aurélien; Cole, Ben; Guyatt, Anna L; Shihab, Hashem A; Maillard, Anne M; Alavere, Helene; Kolk, Anneli; Reigo, Anu; Mihailov, Evelin; Leitsalu, Liis; Ferreira, Anne-Maud; Nõukas, Margit; Teumer, Alexander; Salvi, Erika; Cusi, Daniele; McGue, Matt; Iacono, William G; Gaunt, Tom R ... Reymond, Alexandre (2015). Copy Number Variations and Cognitive Phenotypes in Unselected Populations. JAMA: the journal of the American Medical Association, 313 (20), 2044−2054. DOI: 10.1097/01.ogx.0000471594.65931.90.
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2015
Karmin, Monika; Saag, Lauri; Vicente, Mário; Wilson Sayres, Melissa A; Järve, Mari; Talas, Ulvi Gerst; Rootsi, Siiri; Ilumäe, Anne-Mai; Mägi, Reedik; Mitt, Mario; Pagani, Luca; Puurand, Tarmo; Faltyskova, Zuzana; Clemente, Florian; Cardona, Alexia; Metspalu, Ene; Sahakyan, Hovhannes; Yunusbayev, Bayazit; Hudjashov, Georgi; DeGiorgio, Michael ... Kivisild, Toomas (2015). A recent bottleneck of Y chromosome diversity coincides with a global change in culture. Genome Research, 25 (4), 459−466. DOI: 10.1101/gr.186684.114.
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2015
Joshi, Peter K.; Esko, Tõnu; Mattsson, Hannele; Eklund, Niina; Gandin, Ilaria; Nutile, Teresa; Jackson, Anne U.; Schurmann, Claudia; Smith, Albert V.; Zhang, Weihua; Okada, Yukinori; Stancakova, Alena; Faul, Jessica D.; Zhao, Wei; Bartz, Traci M.; Concas, Maria Pina; Franceschini, Nora; Enroth, Stefan; Vitart, Veronique; Trompet, Stella ... Wilson, James F. (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523 (7561), 459−476. DOI: 10.1038/nature14618.
5.1.
2015
Kaakinen, M.; Maegi, R.; Fischer, K.; Jarvelin, M. -R.; Morris, A. P.; Prokopenko, I. (2015). A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants. Human Heredity, 79: 43rd European Mathematical Genetics Meeting (EMGM), Brest, FRANCE, APR 16-17, 2015. Karger, 39−39. (1).
1.1.
2014
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y14; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J ... Frayling, TM. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173−1186. DOI: 10.1038/ng.3097.
1.1.
2014
Clemente, FJ.; Cardona, A.; Inchley, CE.; Peter, BM.; Jacobs, G.; Pagani, L.; Lawson, DJ.; Antao, T.; Vicente, M.; Mitt, M.; DeGiorgio, M.; Faltyskova, Z.; Xue, YL.; Ayub, Q.; Szpak, M.; Magi, R.; Eriksson, A.; Manica, A.; Raghavan, M.; Rasmussen, M. ... Kivisild, T. (2014). A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations. The American Journal of Human Genetics, 95 (5), 584−589.10.1016/j.ajhg.2014.09.016.
1.1.
2014
Dimas, AS; Lagou, V; Barker, A; Knowles, JW; Magi, R; Hivert, MF; Benazzo, A; Rybin, D; Jackson, AU; Stringham, HM; Song, C; Fischer-Rosinsky, A; Boesgaard, TW; Grarup, N; Abbasi, FA; Assimes, TL; Hao, K; Yang, X Lecoeur, C; Barroso, I; Bonnycastle, LL ... MAGIC, Investigators. (2014). Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity. Diabetes, 63 (6), 2158−2171.10.2337/db13-0949.
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2014
Perry, J.R.B.; Day, F.; Elks, C.E.; Sulem, P.; Thompson, D.J.; Ferreira, T.; He, C.; Chasman, D.I.; Esko, T.; Thorleifsson, G.; Albrecht, E.; Ang, W.Q.; Corre, T.; Cousminer, D.L.; Feenstra, B.; Franceschini, N.; Ganna, A.; Johnson, A.D.; Kjellqvist, S.; Lunetta, K.L. ... Ong, K.K. (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92. DOI: 10.1038/nature13545.
1.1.
2014
Hoggart, CJ; Venturini, G; Mangino, M; Gomez, F; Ascari, G; Zhao, JH; Teumer, A; Winkler, TW; Tsernikova, N; Luan, J; Mihailov, E; Ehret, GB; Zhang, W; Lamparter, D; Esko, T; Mace, A; Rueger, S; Bochud, P-Y; Barcella, M; Dauvilliers, Y ... Kutalik, Z. (2014). Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. PLoS Genetics, 10 (7), e1004508. DOI: 10.1371/journal.pgen.1004508.
1.1.
2014
Metsalu, Tauno; Viltrop, Triin; Tiirats, Airi; Rajashekar, Balaji; Reimann, Ene; Kõks, Sulev; Rull, Kristiina; Milani, Lili; Acharya, Ganesh; Basnet, Purusotam; Vilo, Jaak; Mägi, Reedik; Metspalu, Andres; Peters, Maire; Haller-Kikkatalo, Kadri; Salumets, Andres (2014). Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. Epigenetics, 9 (10), 1397−1409. DOI: 10.4161/15592294.2014.970052.
1.1.
2014
Lim, ET.; Würtz, Peter; Havulinna, AS.; Palta, Priit; Tukiainen, Taru; Rehnström, Karola; Esko, Tõnu; Mägi, Reedik; Inouye, Michael; Lappalainen, Tuuli; Chan, Yingleong; Salem, RM.; Lek, Monkol; Flannick, Jason; Sim, Xueling; Manning, Alisa; Ladenvall, Claes; Bumpstead, Suzannah; Hämäläinen, Eija; Aalto, Kristiina ... SISu, Project (2014). Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population. PLoS Genetics, 10 (7), e1004494. DOI: 10.1371/journal.pgen.1004494.
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2014
Mägi, Reedik; Metspalu, Andres; Mihailov, Evelin (2014). Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nature Genetics, 46 (3), 234−244. DOI: 10.1038/ng.2897.
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2014
Schramm, Katharina; Marzi, Carola; Schurmann, Claudia; Carstensen, Maren; Reinmaa, Eva; Biffar, Reiner; Eckstein, Gertrud; Gieger, Christian; Grabe, Hans-Jorgen; Homuth, Georg; Kastenmuller, Gabriele; Magi, Reedik; Metspalu, Andres; Mihailov, Evelin; Peters, Annette; Petersmann, Astrid; Roden, Michael; Strauch, Konstantin; Suhre, Karsten; Teumer, Alexander ... Prokisch, Holger (2014). Mapping the genetic architecture of gene regulation in whole blood. PLoS ONE, 9 (4), e93844−e93844. DOI: 10.1371/journal.pone.0093844.
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2014
Winkler, T.W.; Day, FR.; Croteau-Chonka, DC.; Wood, AR.; Locke, AE.; Magi, R.; Ferreira, T.; Fall, T.; Graff, M.; Justice, AE.; Luan, JA.; Gustafsson, S.; Randall, JC.; Vedantam, S.; Workalemahu, T.; Kilpelainen, TO.; Scherag, A.; Esko, T.; Kutalik, Z.; Heid, IM. ... Loos, RJF (2014). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5), 1192−1212. DOI: 10.1038/nprot.2014.071.
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2014
Prokopenko, Inga; Poon, Wenny; Magi, Reedik; Prasad B, Rashmi; Salehi, S Albert; Almgren, Peter; Osmark, Peter; Bouatia-Naji, Nabila; Wierup, Nils; Fall, Tove; Stancakova, Alena; Barker, Adam; Lagou, Vasiliki; Osmond, Clive; Xie, Weijia; Lahti, Jari; Jackson, Anne U; Cheng, Yu-Ching; Liu, Jie; O'Connell, Jeffrey R ... Lyssenko, Valeriya (2014). A central role for GRB10 in regulation of islet function in man. PLoS Genetics, 10 (4), e1004235−e1004235.10.1371/journal.pgen.1004235.
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2014
Lokk, Kaie; Modhukur, Vijayachitra; Rajashekar, Balaji; Märtens, Kaspar; Mägi, Reedik; Kolde, Raivo; Koltšina, Marina; Nilsson, Torbjörn K.; Vilo, Jaak; Salumets, Andres; Tõnisson, Neeme (2014). DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns. Genome Biology, 15 (4), R54.10.1186/gb-2014-15-4-r54.
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2014
Fischer, K.; Kettunen, J.; Würtz, P.; Haller, T.; Aki S. Havulinna, A.S.; Kangas, A.J.; Soininen, P.; Esko, T.; Tammesoo, M-L.; Mägi, R.; Smit, S.; Palotie, A.; SRipatti, S.; Veikko Salmaa, V.; Ala-Korpela, M.; Perola, M.; Metspalu, A. (2014). Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons. PLoS Medicine, 11 (2), e1001606. DOI: 10.1371/journal.pmed.1001606.
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2014
Raghavan, M.; Skoglund, P.; Graf, K.E.; Metspalu, M.; Albrechtsen, A.; Moltke, I.; Rasmussen, S.; Stafford, T.W. Jr.; Orlando, L.; Metspalu, E.; Karmin, M.; Tambets, K.; Rootsi, S.; Mägi, R.; Campos, P.F., Balanovska, E., Balanovsky, O., Khusnutdinova, E., Litvinov, S.; Osipova, L.P.; Fedorova, S.A.; Voevoda, M.I.; DeGiorgio, M.; Sicheritz-Ponten, T. ... Willerslev, E. (2014). Upper Palaeolithic Siberian genome reveals dual ancestry of Native Americans. Nature, 505 (7481), 87−91.10.1038/nature12736.
1.1.
2014
Walsh, KM; Codd, V; Smirnov, IV; Rice, T; Decker, PA; Hansen, HM; Kollmeyer, T; Kosel, ML; Molinaro, AM; McCoy, LS; Bracci, PM; Cabriga, BS; Pekmezci, M; Zheng, SC; Wiemels, JL; Pico, AR; Tihan, T; Berger, MS; Chang, SM; Prados, MD ... ENGAGE, Consortium, Teleomere, Grp. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46 (7), 731−735. DOI: 10.1038/ng.3004.
5.1.
2014
Morris, A. P.; Teslovich, T. M.; Ferreira, T.; Mahajan, A.; Lee, Y.; Rayner, N. W.); Magi, R. (2014). Fine-mapping type 2 diabetes susceptibility loci with high-density imputation. DIABETOLOGIA, 57: 50th EASD Annual Meeting, Vienna, Austria, 15-19.09.2014. Springer, S50−S51.
1.1.
2013
Mägi, R.; Manning, S.; Yousseif, A.; Pucci, A.; Santini, F.; Karra, E.; Querci, G.; Pelosini, C.; McCarthy, M.I.; Lindgren, C.M.; Batterham, R.L. (2013). Contribution of 32 GWAS-Identified Common Variants to Severe Obesity in European Adults Referred for Bariatric Surgery. PLoS ONE, 8 (8), e70735.10.1371/journal.pone.0070735.
1.1.
2013
Evans, DM; Brion, MJ; Paternoster, L; Kemp, JP; McMahon, G; Munafò, M; Whitfield, JB; Medland, SE; Montgomery, GW; GIANT, Consortium; CRP, Consortium; TAG, Consortium; Timpson, NJ; St Pourcain, B; Lawlor, DA; Martin, NG; Dehghan, A; Hirschhorn, J; Davey, Smith, G. (2013). Mining the human phenome using allelic scores that index biological intermediates. PLoS Genetics, 9 (10), e1003919−e1003919. DOI: 10.1371/journal.pgen.1003919.
1.1.
2013
Vimaleswaran, KS.; Berry, DJ.; Lu, C.; Tikkanen, E.; Pilz, S.; Hiraki, LT.; Cooper, JD.; Dastani, Z.; Li, R.; Houston, DK.; Wood, AR.; Michaëlsson, K.; Vandenput, L.; Zgaga, L.; Yerges-Armstrong, LM.; McCarthy, MI.; Dupuis, J.; Kaakinen, M.; Kleber, ME.; Jameson, K. ... Hyppönen, E. (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Medicine, 10 (2), e1001383. DOI: 10.1371/journal.pmed.1001383.
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2013
Paul, Dirk S.; Albers, Cornelis A.; Rendon, Augusto; Voss, Katrin; Stephens, Jonathan; HaemGen, Consortium; van der Harst, Pim; Chambers, John C.; Soranzo, Nicole; Ouwehand, Willem H.; Deloukas, Panos (2013). Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci. Genome Research, 23 (7), 1130−1141. DOI: 10.1101/gr.155127.113.
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2013
Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpeläinen, TO; Esko, T; Mägi, R; Li, S; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A ... Heid, IM (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics, 9 (6), e1003500. DOI: 10.1371/journal.pgen.1003500.
1.1.
2013
Thorgeirsson, TE; Gudbjartsson, DF; Sulem, P; Besenbacher, S; Styrkarsdottir, U; Thorleifsson, G; Walters, GB; TAG, Consortium; Oxford-GSK, Consortium; ENGAGE, consortium; Furberg, H; Sullivan, PF; Marchini, J; McCarthy, MI; Steinthorsdottir, V; Thorsteinsdottir, U; Stefansson, K. (2013). A common biological basis of obesity and nicotine addiction. Translational Psychiatry, 3, 1−7. DOI: 10.1038/tp.2013.81.
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2013
Tammiste, Anu; Jiang, Tao; Fischer, Krista; Mägi, Reedik; Krjutškov, Kaarel; Pettai, Kristi; Esko, Tõnu; Li, Yingrui; Tansey, Katherine E; Carroll, Liam S; Uher, Rudolf; McGuffin, Peter; Võsa, Urmo; Tšernikova, Natalia; Saria, Alois; Ng, Pauline C; Eller, Triin; Vasar, Veiko; Nutt, David J; Maron, Eduard ... Metspalu, Andres (2013). Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression. Journal of Psychopharmacology, 27 (10), 915−920. DOI: 10.1177/0269881113499829.
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2013
Fall, T.; Hagg, S.; Magi, R.; Ploner, A.; Fischer, K.; Horikoshi, M.; Sarin, AP.; Thorleifsson, G.; Ladenvall, C.; Kals, M.; Kuningas, M.; Draisma, HHM.; Ried, JS.; van Zuydam, NR.; Huikari, V.; Mangino, M.; Sonestedt, E.; Benyamin, B.; Nelson, CP.; Rivera, NV. ... Prokopenko, I. (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Medicine, 10 (6), e1001474−e1001474. DOI: 10.1371/journal.pmed.1001474.
1.1.
2013
Migliano, A.; Romero, I.; Metspalu, M.; Leavesley, M.; Pagani, L.; Antao, T.; Huang, D.; Sherman, B.; Siddle, K.; Scoles, C.; Hudjashov, G.; Kaitokai, E.; Mandui, H.; Babalu, A.; Belatti, M.; Cagan, A.; Hopkinshow, B.; Show, C.; Tabbada, K.; Nelis, M. ... Kivisild, T. (2013). Evolution of the pygmy phenotype: evidence of positive selection from genome-wide scans in African, Asian and Melanesian pygmies. Human Biology, 85, 251−284.
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2013
Nikopensius, T; Annilo, T; Jagomägi, T; Gilissen, C; Kals, M; Krjutškov, K; Mägi, R; Eelmets, M; Gerst-Talas, U; Remm, M; Saag, M; Hoischen, A; Metspalu, A (2013). Non-syndromic Tooth Agenesis Associated with a Nonsense Mutation in Ectodysplasin-A (EDA). Journal of Dental Research, 92 (6), 507−511. DOI: 10.1177/0022034513487210.
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2013
Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69. DOI: 10.1038/ng.2606.
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2013
Codd, V; Nelson, CP; Albrecht, E; Mangino, M; Deelen, J; Buxton, JL; Hottenga, JJ; Fischer, K; Esko, T; Surakka, I; Broer, L; Nyholt, DR; Leach, IM; Salo, P; Hägg, S; Matthews, MK; Palmen, J; Norata, GD; O'Reilly, PF; Saleheen, D ... Samani, NJ (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45 (4), 422−427. DOI: 10.1038/ng.2528.
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2013
Hu, YJ; Berndt, SI; Gustafsson, S; Ganna, A; Genetic Investigation of ANthropometric Traits (GIANT), Consortium; Hirschhorn, J; North, KE; Ingelsson, E; Lin, DY (2013). Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics. The American Journal of Human Genetics, 93 (2), 236−248.10.1016/j.ajhg.2013.06.011.
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2013
Parsa, A; Fuchsberger, C; Köttgen, A; O'Seaghdha, CM; Pattaro, C; de Andrade, M; Chasman, DI; Teumer, A; Endlich, K; Olden, M; Chen, MH; Tin, A; Kim, YJ; Taliun, D; Li, M; Feitosa, M; Gorski, M; Yang, Q; Hundertmark, C; Foster, MC ... Böger, CA. (2013). Common Variants in Mendelian Kidney Disease Genes and Their Association with Renal Function. Journal of the American Society of Nephrology, 24 (12), 2105−2117. DOI: 10.1681/ASN.2012100983.
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2013
Lagou, V.; Mägi, R.; Surakka, I. ; Sarin, A. -P.; Horikoshi, M.; Thorleifsson, G. ; Hagg, S.; Beekman, M.; Ladenvall, C.; Hottenga, J. -J.; Ried, J. S.; McCarthy, M. I.Morris, A.; Ripatti, S.; Prokopenko, I. (2013). Pleiotropic effects on lipid levels and obesity identified in multi-trait meta-analysis of genome-wide association studies (GWAS) of type 2 diabetes related traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S60.
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2013
Horikoshi, M.; Mägi, R.; Surakka, I.; Sarin, A. -P.; Mahajan, A.; Marullo, L.; Ferreira, T. ; Esko, T.; Lindgren, C. M.; Morris, A. P.; McCarthy, M. I.; Ripatti, S.; Prokopenko, I; ENGAGE, Consortium. (2013). Large-scale genome-wide association meta-analysis of the 1000 genomes project imputed data identifies novel susceptibility loci for glycaemic and obesity traits. DIABETOLOGIA, 56: 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, SEP 23-27, 2013. Springer, S60−S61.
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2013
Horikoshi, Momoko; Magi, Reedik; Surakka, Ida; Sarin, Antti-Pekka; Mahajan, Anubha; Marullo, Letizia; Ferreira, Teresa; Esko, Tonu; Morris, Andrew P.; Mccarthy, Mark I.; Ripatti, Samuli; Prokopenko, Inga (2013). Large-Scale Genome-Wide Association Meta-Analysis using Imputation from the Dense 1000 Genomes Project Map Identifies Novel Susceptibility Loci for Glycemic and Obesity Traits. Diabetes, A83−A83.
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2013
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2013
Tõnisson, N.; Lokk, K; Modhukur, V.; Rajashekar, B; Martens, K; Koltšina, M; Mägi, R.; Kolde, R.; Salumets, A. (2013). DNA metylome comparison of various human tissues. European Journal of Human Genetics: European Human Genetics Conference; Pariis, Prantsusmaa; 8.–11. juuni, 2013. Nature Publishing Group, 373−373. (21; Suppl 2).
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2012
Chasman, DI.; Fuchsberger, C.; Pattaro, C.; Teumer, A.; Boger, CA.; Endlich, K.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Kottgen, A. (2012). Integration of Genome-Wide Association Studies with Biological Knowledge Identifies Six Novel Genes Related to Kidney Function. Human Molecular Genetics, 21 (24), 5329−5343. DOI: 10.1093/hmg/dds369.
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Nürnberg, ST.; Rendon, A.; Smethurst, PA.; Paul, DS.; Voss, K.; Thon, JN.; Lloyd-Jones, H.; Sambrook, JG.; Tijssen, MR.; Gieger, C.; Radhakrishnan, A.; Cvejic, A.; Tang, W.; Porcu, E.; Pistis, G.; Serbanovic-Canic, J.; Elling, U.; Goodall, AH.; Labrune, Y.; Lopez, LM. ... Ouwehand, W. (2012). A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood, 120 (24), 4859−4868. DOI: 10.1182/blood-2012-01-401893.
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Mägi, R; Asimit, JL; Day-Williams, AG; Zeggini, E; Morris, AP. (2012). Genome-Wide Association Analysis of Imputed Rare Variants: Application to Seven Common Complex Diseases. Genetic Epidemiology, 36 (8), 785−796.10.1002/gepi.21675.
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Okada, Y; Sim, X; Go, MJ; Wu, JY; Gu, D; Takeuchi, F; Takahashi, A; Maeda, S; Tsunoda, T; Chen, P; Lim, SC; Wong, TY; Liu, J; Young, TL; Aung, T; Seielstad, M; Teo, YY; Kim, YJ; Lee, JY; Han, BG ... Gieger, C. (2012). Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. Nature Genetics, 44 (8), 904−909. DOI: 10.1038/ng.2352.
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2012
Yang, J; Loos, RJ; Powell, JE; Medland, SE; Speliotes, EK; Chasman, DI; Rose, LM; Thorleifsson, G; Steinthorsdottir, V; Mägi, R; Waite, L; Vernon, Smith, A; Yerges-Armstrong, LM; Monda, KL; Hadley, D; Mahajan, A; Li, G; Kapur, K; Vitart, V; Huffman, JE ... Visscher, PM (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature, 490 (7419), 267−272. DOI: 10.1038/nature11401.
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2012
Scott, RA.; Lagou, V.; Welch, RP.; Wheeler, E.; Montasser, ME.; Luan, J.; Mägi, R.; Strawbridge, RJ.; Rehnberg, E.; Gustafsson, S.; Kanoni, S.; Rasmussen-Torvik, LJ.; Yengo, L.; Lecoeur, C.; Shungin, D.; Sanna, S.; Sidore, C.; Johnson, PC.; Jukema, JW.; Johnson, T. ... Barroso, I. (2012). Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nature Genetics, 44 (9), 991−1005. DOI: 10.1038/ng.2385.
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2012
Fox, Caroline S; Liu, Yongmei; White, Charles C; Feitosa, Mary; Smith, Albert V; Heard-Costa, Nancy; Lohman, Kurt; Johnson, Andrew D; Foster, Meredith C; Greenawalt, Danielle M; Griffin, Paula; Ding, Jinghong; Newman, Anne B; Tylavsky, Fran; Miljkovic, Iva; Kritchevsky, Stephen B; Launer, Lenore; Garcia, Melissa; Eiriksdottir, Gudny; Carr, J Jeffrey ... GLGC, Consortium. (2012). Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women. PLoS Genetics, 8 (5), e1002695−e1002695.10.1371/journal.pgen.1002695.
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Ikram, MA.; Fornage, M.; Smith, AV.; Seshadri, S.; Schmidt, R.; Debette, S.; Vrooman, HA.; Sigurdsson, S.; Ropele, S.; Taal, HR.; Mook-Kanamori, DO.; Coker, LH.; Longstreth, WT.; Niessen, WJ.; DeStefano, AL.; Beiser, A.; Zijdenbos, AP.; Struchalin, M.; Jack, CR.; Rivadeneira, F. ... Wilson, JF. (2012). Common variants at 6q22 and 17q21 are associated with intracranial volume. Nature Genetics, 44 (5), 539−544.10.1038/ng.2245.
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Manning, AK.; Hivert, MF.; Scott, RA.; Grimsby, JL.; Bouatia-Naji, N.; Chen, H.; Rybin, D.; Liu, CT.; Bielak, LF.; Prokopenko, I.; Amin, N.; Barnes, D.; Cadby, G.; Hottenga, JJ.; Ingelsson, E.; Jackson, AU.; Johnson, T.; Kanoni, S.; Ladenvall, C.; Lagou, V. ... Langenberg, C. (2012). A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics, 44 (6), 659−669.10.1038/ng.2274.
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Bradfield, JP.; Taal, HR.; Timpson, NJ.; Scherag, A.; Lecoeur, C.; Warrington, NM.; Hypponen, E.; Holst, C.; Valcarcel, B.; Thiering, E.; Salem, RM.; Schumacher, FR.; Cousminer, DL.; Sleiman, PMA.; Zhao, JH.; Berkowitz, RI.; Vimaleswaran, KS.; Jarick, I.; Pennell, CE.; Evans, DM. ... Grant, SFA. (2012). A genome-wide association meta-analysis identifies new childhood obesity loci. Nature Genetics, 44 (5), 526−531.10.1038/ng.2247.
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Pattaro, C.; Köttgen, A.; Teumer, A.; Garnaas, M.; Boger, CA.; Fuchsberger, C.; Olden, M.; Chen, MH.; Tin, A.; Taliun, D.; Li, M.; Gao, XY.; Gorski, M.; Yang, Q.; Hundertmark, C.; Foster, MC.; O'Seaghdha, CM.; Glazer, N.; Isaacs, A.; Liu, CT. ... Fox, CS. (2012). Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function. PLoS Genetics, 8 (3), e1002584−e1002584. DOI: 10.1371/journal.pgen.1002584.
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Palmer, Nicholette D; McDonough, Caitrin W; Hicks, Pamela J; Roh, Bong H; Wing, Maria R; An, S Sandy; Hester, Jessica M; Cooke, Jessica N; Bostrom, Meredith A; Rudock, Megan E; Talbert, Matthew E; Lewis, Joshua P; Ferrara, Assiamira; Lu, Lingyi; Ziegler, Julie T; Sale, Michele M; Divers, Jasmin; Shriner, Daniel; Adeyemo, Adebowale; Rotimi, Charles N ... Sladek, Robert (2012). A genome-wide association search for type 2 diabetes genes in African Americans. PLOS ONE, 7 (1), e29202−e29202.
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2012
Mägi, R; Morris, AP. (2012). Genome-wide association analysis of rare variants identifies potential novel susceptibility genes for type 1 diabetes and coronary artery disease. ANNALS OF HUMAN GENETICS, 76: European Mathematical Genetics Meeting, Gottingen, GERMANY, APR 12-13, 2012. Wiley-Blackwell, 421−422.
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Mägi, R; Horikoshi, M; Surakka, I; Wiltshire, S; Sarin, AP; Mahajan, A; Marullo, L; Ferreira, T; Hagg, S; Ried, JS; Winkler, T; Thorleifsson, G; Tsernikova, N; Esko, T; Willenborg, C; Nelson, CP; Beekman, M; Willems, SM; McCarthy, MI; Morris, AP ... Prokopenko, I. (2012). Large-scale Genome-wide Association Meta-analysis Using Imputation from 2188-haplotype 1000 Genomes Reference Panel Identifies Novel Susceptibility Loci for Anthropometric and Glycemic Traits. GENETIC EPIDEMIOLOGY, 36: Annual Meeting of the International-Genetic-Epidemiology-Society (IGES), Stevenson, WA, OCT 18-20, 2012. Wiley-Blackwell, 776−777. (7).
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Dimas, A.S.; Gomes, V.I.; Knowles, J.; Mägi, R.; Barker, A.; Hivert, M.-F.; Benazzo, A.; Rybin, D.; Assimes, T.I.; Ouertermous, T.; Walker, M.; Florez, J.C.; Barroso, I.; Langenberg, Cl.; Dupuis, J.; Watanabe, R.; McCarthy, M.; Ingelsson, E.; Prokopenko, I. (2012). Impact of Type 2 Diabetes Susceptibility Loci on Variation in Physiologic Glycaemic Traits in Non-Diabetic Individuals. Circulation, 126: AHA Scientific Session 2012, Los Angeles, USa, 3-7. Nov.. Lippincott Williams & Wilkins, 14977. (21).
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Bailey-Wilson, JE.; Brennan, JS.; Bull, SB.; Culverhouse, R.; Kim, Y.; Jiang, Y.; Jung, JS.; Li, Q.; Lamina, C.; Liu, Y.; Magi, R.; Niu, YS.; Simpson, CL.; Wang, LB.; Yilmaz, YE.; Zhang, HP.; Zhang, ZG. (2011). Regression and data mining methods for analyses of multiple rare variants in the Genetic Analysis Workshop 17 mini-exome data. Genetic Epidemiology, 35, S92−S100.
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Chambers, JC; Zhang, WH; Sehmi, J; Li, XZ; Wass, MN; Van der Harst, P; Holm, H; Sanna, S; Kavousi, M; Baumeister, SE; Coin, LJ; Deng, GH; Gieger, C; Heard-Costa, NL; et, al. (2011). Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics, 43 (11), 1131−1138. DOI: 10.1038/ng.970.
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Gieger, C; Radhakrishnan, A; Cvejic, A; Tang, WH; Porcu, E; Pistis, G; Serbanovic-Canic, J; Elling, U; Goodall, AH; Labrune, Y; Lopez, LM; Magi, R; Meacham, S; Okada, Y; Pirastu, N; Sorice, R; Teumer, A; Voss, K; Zhang, WH; Ramirez-Solis, R ... Soranzo, N (2011). New gene functions in megakaryopoiesis and platelet formation. Nature, 480 (7376), 201−208.
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Metspalu, M.; Romero, IG.; Yunusbayev, B.; Chaubey, G.; Mallick, CB.; Hudjashov, G.; Nelis, M.; Mägi, R.; Metspalu, E.; Remm, M.; Pitchappan, R.; Singh, L.; Thangaraj, K.; Villems, R.; Kivisild, T. (2011). Shared and unique components of human population structure and genome-wide signals of positive selection in South Asia. The American Journal of Human Genetics, 89 (6), 731−44.10.1016/j.ajhg.2011.11.010.
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2011
Kilpelaeinen, Tuomas O.; den Hoed, Marcel; Ong, Ken K.; Grontved, Anders; Brage, Soren; Jameson, Karen; Cooper, Cyrus; Khaw, Kay-Tee; Ekelund, Ulf; Wareham, Nicholas J.; Loos, Ruth J. F. Early Growth Genetics Consortium, incl. Mägi R (2011). Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. American Journal of Clinical Nutrition, 93 (4), 851−860.10.3945/ajcn.110.000828.
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The International Consortium for Blood Pressure Genome-Wide Association Studies, incl. Sõber, S.; Snieder, H.; Org, E.; Veldre, G.; Viigimaa, M.; Laan, M. (2011). Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature, 478 (7367), 103−109. DOI: 10.1038/nature10405.
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Wain, L.V.; Verwoert, G.C.; O'Reilly, P.F.; Shi, G.; Johnson, T.; Johnson, A.D.; Bochud, M.; Rice, K.M.; Henneman, P.; Smith, A.V.; Ehret, G.B.; Amin, N.; Larson, M.G.; Mooser, V.; Hadley, D.; Dörr, M.; Bis, J.C.; Aspelund, T.; Esko, T.; Janssens, A.C. ... Metspalu, A. et al (2011). Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nature Genetics, 43, 1005−1011. DOI: 10.1038/ng.922.
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Böger, CA; Chen, MH; Tin, A; Olden, M; Köttgen, A; de Boer, IH; Fuchsberger, C; O’Seaghdha, CM; Pattaro, C; Teumer, A; et, al. (2011). CUBN is a gene locus for albuminuria. Journal of the American Society of Nephrology, 22, 555−570.
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Männik, K; Parkel, S; Palta, P; Zilina, O; Puusepp, H; Esko, T; Mägi, R; Nõukas, M; Veidenberg, A; Nelis, M; Metspalu, A; Remm, M; Ounap, K; Kurg, A. (2011). A parallel SNP array study of genomic aberrations associated with mental retardation in patients and general population in Estonia. European Journal of Medical Genetics, 54 (2), 136−143.
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2011
Mägi, R.; Kumar, A.; Morris, AP. (2011). Assessing the impact of missing genotype data in rare variant association analysis. BMC Proceedings, 9 (5), S107−S107.
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2010
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Mägi, Reedik; Lindgren, Cecilia M.; Morris, Andrew P. (2010). Meta-analysis of sex-specific genome-wide association studies. Genetic Epidemiology, 34 (8), 846−853.10.1002/gepi.20540.
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Dupuis, J.; Langenberg, C.; Prokopenko, I.; Saxena, R.; Soranzo, N.; Jackson, A.U.; Wheeler, E.; Glazer, N.L.; Bouatia-Naji, N.; Gloyn, A.L.; Lindgren, C.M.; Mägi, R.; Morris, A.P.; Randall, J.; Johnson, T.; Elliott, P.; Rybin, D.; Thorleifsson, G.; Steinthorsdottir, V.; Henneman, P. ... Mitchell, B.D (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42 (2), 105−116.10.1038/ng.520.
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Mägi, R; Morris, AP. (2010). GWAMA: software for genome-wide association meta-analysis. BMC Bioinformatics, 11 (288), 288.10.1186/1471-2105-11-288.
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Ingelsson, E.; Langenberg, C.; Hivert, M.F.; Prokopenko, I.; Lyssenko, V.; Dupuis, J.; Mägi, R.; Sharp, S.; Jackson, A.U.; Assimes, T.L.; Shrader, P.; Knowles, J.W.; Zethelius, B.; Abbasi, F.A.; Bergman, R.N.; Bergmann, A.; Berne, C.; Boehnke, M.; Bonnycastle, L.L.; Bornstein, S.R. ... Florez, JC. (2010). Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans. DIABETES, 59: 59th Annual Meeting of the American-Society-of-Human-Genetics; Honolulu, HI, USA; OCT 20-24, 2009. 1266−1275. (5).10.2337/db09-1568.
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Köttgen, A.; Pattaro, C.; Böger, C.A.; Fuchsberger, C.; Olden, M.; Glazer, N.L.; Parsa, A.; Gao, X.; Yang, Q.; Smith, A.V.; O'Connell, J.R.; et, al.; Mägi, R.; et, al. (2010). New loci associated with kidney function and chronic kidney disease. Nature Genetics, 42 (5), 376−384.10.1038/ng.568.
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Mägi, R.; Hottenga, J. J.; Prokopenko, I. (2010). A genome-wide association analysis of over 75,000 individuals identifies gender-specific effects for fasting glycaemic traits. Diabetologia, 53: 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), Stockholm, SWEDEN, SEP 20-24, 2010. Springer, S28−S28.
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Mägi, R; Morris, AP. (2010). GRANVIL: Rare Variant Analysis of Genome-Wide Association Studies. Genetic Epidemiology, 34: 19th Annual Meeting of the International-Genetic-Epidemiology-Society, Boston, MA, OCT 10-12, 2010. Wiley-Blackwell, 926−926. (8).
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Kuningas, M.; Mägi, R.; Westendorp, R.G.; Slagboom, P.E.; Remm, M.; van Heemst, D. (2007). Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. European Journal of Human Genetics, 15 (3), 294−301. DOI: 10.1038/sj.ejhg.5201766.
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Kaminski, S.; Brym, P.; Rusc, A.; Wojcik, E.; Ahman, A.; Mägi, R. (2006). Associations between milk performance traits in Holstein cows and 16 candidate SNPs identified by arrayed primer extension (APEX) microarray. Animal biotechnology, 17 (1), 1−11.
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Montpetit, A.; Nelis, M.; Laflamme, P.; Magi, R.; Ke, X.Y.; Remm, M.; Cardon, L.; Hudson, T.J.; Metspalu, A. (2006). An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population. PLoS Genetics, 2 (3), 282−290.
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Mägi, R.; Kaplinski, L.; Remm, M. (2006). The Whole Genome TagSNP Selection and Transferability Among HapMap Populations. Pacific Symposium on Biocomputing 2006: 2006. World Scientific Publ Co Pte Ltd, 535−543.
1.1.
2005
Mueller, J. C.; Lõhmussaar, E.; Mägi, R.; Remm, M.; Bettecken, T.; Lichtner, P.; Huber, S.; Illig, T; Luedemann, J.; Schreiber, S.; Wichmann, H. E.; Pramstaller, P.; Romeo, G.; Testa, A.; Metspalu, A.; Meitinger, T. (2005). Linkage Disequilibrium Patterns and tagSNP Transferability among European Populations. The American Journal of Human Genetics, 76 (3), 387−398.
1.1.
2002
Liira, J.; Zobel, K.; Magi, R.; Molenberghs, G. (2002). Vertical structure of herbaceous canopies: the importance of plant growth-form and species-specific traits. Plant Ecology, 163 (1), 123−134.
1.1.
2002
Dawson, E.; Abecasis, GR.; Bumpstead, S.; Chen, Y.; Hunt, S.; Beare, DM.; Pabial, J.; Dibling, T.; Tinsley, E.; Kirby, S.; Carter, D.; Papaspyridonos, M.; Livingstone, S.; Ganske, R.; Lohmmussaar, E.; Zernant, J.; Tonisson, N.; Remm, M.; Magi, R.; Puurand, T. ... Dunham, I. (2002). A first-generation linkage disequilibrium map of human chromosome 22. Nature, 418 (6897), 544−548.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using APEX arrays. European Journal of Human Genetics, 10, 299−299.
5.1.
2002
Lohmussaar, E.; Zernant, J.; Magi, R.; Puurano, T.; Tonisson, N.; Valvas, I.; Slavin, G.; Kurg, A.; Remm, M.; Metspalu, A. (2002). SNP analysis and linkage disequilibrium map of the human chromosome 22 using Arrayed Primer EXtension (APEX) technology. The American Journal of Human Genetics, 71 (4), 449−449.
5.1.
2001
Metspalu, A.; Zernant, J.; Lohmussaar, E.; Magi, R.; Kepp, K.; Puurand, T.; Tonisson, N.; Valvas, L.; Pavel, H.; Slavin, G.; Andreson, R.; Kurg, A.; Remm, M. (2001). SNP analysis of the human chromosome 22 using APEX arrays. The American Journal of Human Genetics, 69 (4), 408−408.

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
1.2.5.MP1GV17428; MP1GI17428 (2R01DK075787-11)Antropomeetriliste tunnuste geneetilise arhitektuuri süvauuringud kogu alleelisageduste spektri ulatuses15.08.201731.07.2020Tõnu EskoTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu; Tartu Ülikool, Tartu Ülikooli genoomika instituut155 127,53 EUR
SFSF0180026s09Bioinformaatika rakendamine genoomijärjestuste uurimiseks 01.01.200931.12.2014Maido RemmTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond546 107,92 EUR
2.2.1.VP1GI19662 BioMarin18.12.201901.10.2021Tõnu EskoTartu Ülikool, Tartu Ülikooli genoomika instituut568 635,00 EUR
1.2.2.3.SP1GI20626 (105668)COVIDMENT - Vaimse haigestumuse trajektoorid COVID-19-ga seoses viie riigi riskipopulatsioonides01.11.202031.12.2022Kelli LehtoTartu Ülikool, Tartu Ülikooli genoomika instituut147 210,00 EUR
2.1.1.LP1GI19663 Dermtest19.12.201901.05.2024Tõnu EskoTartu Ülikool, Tartu Ülikooli genoomika instituut16 000,00 EUR
1.2.3.4.MMVCM20443R (952516)Eetiliselt vastutustundlikud uuendused reproduktiivmeditsiinis01.09.202031.08.2023Andres SalumetsTartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut382 750,00 EUR
2.2.1.VP1GV17047Epidemioloogiline uuring toitainete ja rasvumise rolli tuvastamiseks atoopilise dermatiidi ja akne puhul01.09.201731.12.2018Reedik MägiTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu70 463,52 EUR
SFSF0180142Cs08Geneetiline varieeruvus, elustiil ja keskkonnategurid kui peamised tervise mõjurid - EGV01.01.200831.12.2013Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu459 958,57 EUR
2.1.1.LP1GI19572 Geneetilist riskiskooride arendamine02.09.201930.06.2020Tõnu EskoTartu Ülikool, Tartu Ülikooli genoomika instituut118 876,00 EUR
TKSLTMR16142T (TK142)Genoomika ja Siirdemeditsiini Tippkeskus (TK142)01.01.201601.03.2023Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu4 474 349,50 EUR
SFSF0182649s04Inimese genoomi haplotüüpse struktuuri analüüs (0182649s04)01.01.200431.12.2008Maido RemmTartu Ülikool, Bioloogia-geograafiateaduskond224 329,88 EUR
1.2.3.4.MLTGI21016R (101016775)INTERVENE - Integreeritud geneetiliste riskimudelite rahvusvaheline konsortsium01.01.202131.12.2025Reedik MägiTartu Ülikool, Tartu Ülikooli genoomika instituut1 120 656,25 EUR
ETFETF6041Konserveerunud järjestuselementide detekteerimine eukarüootsetes genoomides võrdleva genoomika abil01.01.200531.12.2006Maido RemmEesti Biokeskus12 910,15 EUR
MUUPP1GI19935Koopiaarvu muutuste mõju komplekshaigustele07.08.201930.06.2020Reedik MägiTartu Ülikool, Tartu Ülikooli genoomika instituut50 000,00 EUR
PRGPRG243Looduslik valik ja migratsioonid inimese geneetilise varieeruvuse kujunemisel Ida Euroopa lauskmaal. Vana-DNA uurimus01.01.201831.12.2022Mait MetspaluTartu Ülikool, Tartu Ülikooli genoomika instituut914 112,50 EUR
MUUVP1GV13124Metaboloomika ja genoomika uuring kehakaalu mõjutavate faktorite identifitseerimiseks05.07.201331.12.2016Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu810 800,00 EUR
MUUSBGMR06013Mobiilsustoetus Pacific Sypmosium of Biocomputing01.01.200611.01.2006Reedik MägiTartu Ülikool1 278,23 EUR
IUTIUT20-60Oomiksi põhised meetodid terviseuuringutes: integreeritud lähenemine haiguste tekkeprotsesside mõistmiseks ja prognoosimiseks01.01.201431.12.2019Andres MetspaluTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu; Tartu Ülikool, Tartu Ülikooli genoomika instituut1 327 800,00 EUR
1.2.3.4.MLTGI21024R (101017802)OPTOMICS - Optoakustiliste fenotüübi andmete ja multi-oomika kombineerimine diabeediga seotud tervishoiu edendamiseks 01.01.202131.12.2025Reedik MägiTartu Ülikool, Tartu Ülikooli genoomika instituut670 375,00 EUR
MUUSP1GV15007TPersonaalse meditsiini pilootprojekt "Eestlaste genoomivarieeruvuse andmebaasi loomine"01.01.201531.08.2015Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu1 740 042,00 EUR
2.1.1.LP1GI19450 Polügeensete riskiskooride valideerimine Eesti Geenivaramu andmestikul20.06.201920.06.2022Tõnu EskoTartu Ülikool, Tartu Ülikooli genoomika instituut32 500,00 EUR
ETFETF9353Põhjuslike seoste analüüsi metoodika uuringutes mis kasutavad tavalist või Mendeli randomiseerimist01.01.201231.12.2015Krista FischerTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu60 000,00 EUR
MUUSP1GVARENGSiirdegenoomika keskus01.01.201131.12.2015Ursel Soomets; Andres MetspaluTartu Ülikool; Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu3 500 000,00 EUR
PRGPRG687Suuremahuliste genoomika andmete kasutus ja metoodika arendus geneetiliste haigusriskide hinnangute väljatöötamiseks01.01.202031.12.2020Reedik MägiTartu Ülikool, Tartu Ülikooli genoomika instituut237 875,00 EUR
MUUSP1GV16037T ( EU48684 / 4.1)Technologies for Information Extraction, data integration and management01.12.201530.06.2022Tõnu EskoTartu Ülikool, Tartu Ülikooli Eesti Geenivaramu229 232,00 EUR