Teenistuskäik

Töökohad ja ametid
01.10.2016–...   
Tallinna Ülikool, Loodus- ja terviseteaduste instituut, Teadur (1,00)
15.08.2014–15.09.2016   
Karolinska Institute, Järeldoktor (1,00)
01.09.2010–31.03.2014   
University of Bonn, Järeldoktor (1,00)
01.06.2010–31.07.2010   
University of Ottawa, Järeldoktor (1,00)
01.01.2006–31.12.2009   
Ottawa Ülikool, assistent
01.01.2002–31.12.2002   
Ottawa Ülikool, assistent
 
 
Haridustee
2005–2010   
Ottawa Ülikool, doktorantuur
2002–2005   
British Columbia Ülikool, MSc
1998–2002   
Ottawa Ülikool, BSc (hon)
 
 
Teenistuskäigu lisainfo

Organiser of Tallinn University Brain Awareness Week, March 13th-19th, 2017

List of Events: art exhibition (patient art collection of the North Estonia Medical Centre psychiatry clinic); 2 sessions of talks by researchers from Tallinn University, Tallinn University of Technology, and University of Tartu; dissemination of daily Brain Fact/Tip on social media (Facebook, Twitter); workshops for elementary (2 classes) and high school students (2 classes); art exhibit with cloud imagery to encourage adults to be imaginative again and explain the phenomenon of pareidolia; film screenings (x3) relevant to mental health followed by Q&A with experts

Role: “Brain behind Brain Awareness Week”; Organiser, Concept and Creative Designer
Content creation: Brain Fact and Tips for dissemination on social media; workshop on subject of brain anatomy, optical illusions, pareidolia, and selective attention for elementary school students; text explaining the phenomenon of pareidolia
Other Tasks: Recruitment of volunteers, selection of films and recruitment of experts for Q&A session following screenings, Contact and recruitment of researchers for lecture series, creation of English language posters and postering, creation of English version of website (content only, no upload);

Teaching activities:
(2017) Guest Lecturer in Psycholinguistics GRT7304, School of Humanities, Tallinn University / Lecture Title: On learning and memory / Concept and creation of a lecture on the neuroanatomy and mechanisms of learning & memory geared toward students of translation studies.
(2014) Lecturer in Cellular and Behavioral Genetics WPM4, Institute for Molecular Psychiatry, University of Bonn / Lecture Title: Transcriptional Regulation of Gene Expression
(2011-2013) Lecturer and Practical Laboratory Supervisor in Cellular and Behavioral Genetics WPM4, Institute for Molecular Psychiatry, University of Bonn / Lecture Title: Transcriptional Regulation of Gene Expression / Description: This lecture pertained to the basic mechanisms of gene transcription with focus on regulatory control, epigenetics, and transcript stability. The practical laboratory session consisted of reverse transcription of mRNA into cDNA using oligo(dT) priming followed by real-time PCR using TaqMan Gene Expression Assays and data analysis of results. An overview of the background theory, methodology, data analysis and interpretation were also given in written course material that I devised.
(2010) Lecturer for Brain Awareness Week with the Society for Neuroscience, Ottawa Chapter / Topic: The brain and drugs of abuse
(2009) Teaching Assistant in BPS4900 B – Seminar, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks:
attend student presentations on assigned journal articles and to provide questions, feedback and an evaluation of the students’ presentation skills
(2008) Laboratory Demonstrator for BCH2333 (English) and BCH2733 (French) – Introduction to Biochemistry/Laboratoire de Biochimie I, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and to correct lab reports. / Experiment: Bligh and Dyer lipid extraction and visualization using 2D thin layer chromatography
(2007) Laboratory Demonstrator for BCH2733 – Laboratoire de Biochimie I, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and to correct lab reports. / Experiment: Bligh and Dyer lipid extraction and visualization using 2D thin layer chromatography
(2006) Laboratory Demonstrator for BCH3356 – Molecular Biology Laboratory, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and correct lab reports / Experiments: isolation of total RNA using Tri-Reagent, isolation of poly(A)+ RNA via oligo-d(T) column, RT-PCR, T/A cloning into pBluescript vector, miniprep bacterial plasmid isolation, in vitro transcription/translation, site-directed mutagenesis, endonuclease restriction digest & agarose gel electrophoresis, Northern, Southern, and Western blotting.
(2004) Tutorial Lecturer for the Summer Science 101 Program
Faculty of Science, University of British Columbia (August 4th, 2004) / Topic: Human Physiology
(2002) Laboratory Demonstrator for BCH 2736 – Laboratoire de Biochimie I, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and to correct lab reports. / Experiment: Bligh and Dyer lipid extraction and visualization using 2D thin layer chromatography ;

Supervised Staff:
(2013) Blanca Randel, Biological Technical Assistant, Institute for Molecular Psychiatry, University of Bonn;

Supervised Students:
(2012) Katharina Schulenberg (Master’s rotation student, 8 weeks, University of Bonn) / Project: Determination of glial cell number in CB2-/- mice
(2011) Michael Saynisch (Bachelor trainee, 2 weeks, University of Bonn) / Project: Immunostaining of synapsin1 in D-amino acid oxidase overexpressing mice trained in a Morris Water Maze
(2010) Chloé Corbeil (summer student, 16 weeks, University of Ottawa) / Project: Immunostaining and in situ hybridization of LY receptor in mouse brain
(2009) Luca Giurgea (Bachelor’s Honours Thesis, 8 months, University of Ottawa) / Project: Characterization of kainic-acid induced injury in connexin29/32 double-null mutant mice;
Organiser of Tallinn University Brain Awareness Week, March 12th-18th, 2018

List of Events: "The Brain as Art" exhibition (March 5 - April 15th) ; lecture series with researchers from Tallinn University, University of Tartu, Uppsala University; dissemination of daily Brain Fact/Tip on social media (Facebook, Twitter); workshops for elementary and high school students; art exhibit with cloud imagery to encourage adults to be imaginative again and explain the phenomenon of pareidolia

Role: Organiser, Concept and Creative Designer, presenter of seminar, host of lecture series
Content creation: Brain Fact and Tips for dissemination on social media; custom workshops based on student questions for Grade 3 and Grade 9 students; creation of art exhibit pieces based on own work;

Kvalifikatsioon

 
 
Teaduspreemiad ja tunnustused
2013, Sophie Imbeault, Start-up funding for research groups, 54 820€ (grant covers the salary of a technician and consumables for 1 year), University of Bonn Faculty of Medicine BONFOR research funding. (Postdoctoral, competitive award)
2009, Sophie Imbeault, Fisher Scientific Faculty of Medicine Doctoral Excellence Award, 555CAD. (Doctoral, competitive award)
2007, Sophie Imbeault, Ontario Graduate Scholarship in Science in Technology (with support from the Parkinson Research Consortium and Centre for Stroke Recovery), 42 000CAD for 3 years (2007-2010). (Doctoral, competitive award)
2005, Sophie Imbeault, University of Ottawa Excellence Scholarship, value of tuition (approx. 33 000CAD over 5 years, 2005-2010). (Doctoral, non-competitive award)
2005, Sophie Imbeault, National Science and Engineering Research Council (NSERC) Postgraduate Scholarship, 42 000 CAD over 2 years (2005-2007). (Doctoral, competitive award)
2005, Sophie Imbeault, University of Ottawa Strategic Areas of Development Award, 6 000CAD. (Doctoral, non-comptetitive award)
2004, Sophie Imbeault, NSERC Postgraduate Scholarship, 17 300CAD for one year. (Master's, competitive award)
2003, Sophie Imbeault, Michael Smith Foundation for Health Research Master's Trainee Award, top up award of 19 400CAD + 5 000CAD research and travel for 2 years (2003-2005). (Master's, competitive award)
2003, Sophie Imbeault, Canada Graduate Scholarship, 17 500 CAD for one year. (Master's, competitive award)
2002, Sophie Imbeault, University of British Columbia Faculty of Graduate Studies Graduate Entrance Scholarship, 3 000CAD. (Master's, non-competitive award)
2002, Sophie Imbeault, Graduated B.Sc. (Honours) Summa Cum Laude
2001, Sophie Imbeault, NSERC Undergraduate Student Research Award, 5 000CAD. (Bachelor's, competitive award)
1998, Sophie Imbeault, University of Ottawa Admission Scholarship, 10 000CAD over 4 years (1998-2002). (Bachelor's, non-competitive award)
1998, Sophie Imbeault, NavCanada Scholarship, 6 000CAD over 4 years (1998-2002). (Bachelor's, competitive award)
1998, Sophie Imbeault, Dean's Honour List, 4 years (1998 - 2002).
 
 
Teadustöö põhisuunad
VALDKOND: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS ERIALA: B210 Histoloogia, tsütokeemia, histokeemia, koekultuurid
 
 
Lisainfo
Research Projects:

(08/2014-09/2016 ) Postdoctoral Fellow in Psychoneuroimmunology at Karolinska Institutet (Sweden), Supervisor: Dr. Sophie Erhardt

Projects investigate the role of the kynurenine pathway, and kynurenic acid in particular, in rodent models of psychiatric disorders. Previous research in the laboratory has shown elevated kynurenic acid levels in cerebrospinal fluid of schizophrenia patients. I use pharmacological and transgenic mouse models to manipulate the kynurenine pathway and assess the impact of these changes on cognitive function and psychosis-related behaviours. The aim is to validate these models and use them to discover and test novel therapeutics.

(09/2010 – 03/2014) Postdoctoral Research Fellow at the University of Bonn (Germany), Supervisor: Prof. Dr. Andreas Zimmer

Research Project 1: Effects of adolescent cannabis consumption on brain maturation and psychosis

This project looked at the effect of cannabis administration in adolescence on psychosis-related behaviours in adulthood and the possible underlying mechanisms. Using a behavioural testing panel relevant to schizophrenia, deficits were found in tests reflecting negative and cognitive but not positive symptoms of schizophrenia. Microarray analysis revealed differentially expressed gene sets between animals immediately after treatment (P28) and after a 12 week washout period (P112) suggesting cannabis not only alters long-term gene expression but also brain development.

Research Project 2 : Characterization of D-amino oxidase (DAO) overexpressing mice

Increased expression and activity of DAO has been observed in post-mortem schizophrenia patient samples. We created a transgenic mouse line overexpressing DAO in astrocytes (hGFAP-DAO) and backbred it onto a C57Bl/6J background strain. These mice show decreased D-serine levels in multiple brain regions including the hippocampus. A behavioural testing panel revealed a slight increase in memory flexibility in DAO overexpressing mice during reversal training in a Morris Water Maze but no other significant behavioural phenotype.

(05/2005 – 05/2010) Ph.D. Biochemistry at the University of Ottawa (Canada), Supervisor: Dr. Steffany A.L. Bennett
Thesis: Connexin-mediated regulation of gliogenesis

Novel connexin protein expression was assessed in progenitor cells within the hippocampal formation or from hippocampal-derived progenitors in vitro. Localization of connexin proteins to novel cell types using co-labeling was shown. Phenotypic analysis of progenitor cell type, proliferation and specification were carried out both in vitro and in vivo and demonstrated a role for connexin-mediated regulation of gliogenesis within the hippocampus.

(09/2002 – 05/2005) M.Sc. Neuroscience at the University of British Columbia (Canada), Supervisor: Dr. Timothy H. Murphy
Thesis: Overexpression of Nrf2 via viral-mediated gene transfer in vivo

Following optimization of viral dosage and expression, a viral-vector expressing Nrf2, which is involved in upregulation of antioxidant defenses, was delivered to the striatum via stereotactic injection in a neurodegeneration model using the mitochondrial toxin 3-nitropropionic acid. Nrf2 overexpression lead to reduced volume loss as determined by Nissl staining, reduced gliosis and reduced neuronal loss.

(09/1998 – 05/2002) B.Sc. Hon. Biochemistry, University of Ottawa (Canada), Summa cum Laude
Honours Thesis: Effect of ectopic expression of GPR4 on viability, proliferation, and differentiation of PC12 cells – a role for sphingosylphosphocholine

This honours thesis project sought to identify ligands for the then-orphan receptor GPR4. A GPR4 construct was transfected into the PC12 cell-line and various ligands tested on survival, proliferation, and differentiation of the cells.

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2017
1.1.
2016
1.1.
2016
1.1.
2016
5.2.
2016
5.2.
2015
5.2.
2014
1.1.
2013
5.2.
2011
1.2.
2010
1.1.
2009
1.1.
2005
1.1.
2002
16.04.2018

Career

Institution(s) and position(s)
01.10.2016–...   
Tallinn University, School of Natural Sciences and Health, Researcher (1,00)
15.08.2014–15.09.2016   
Karolinska Institute, Post-Doc (1,00)
01.09.2010–31.03.2014   
University of Bonn, University of Bonn - Postdoctoral Fellow (1,00)
01.06.2010–31.07.2010   
University of Ottawa, University of Ottawa - Postdoctoral Fellow (1,00)
01.01.2006–31.12.2009   
University of Ottawa, teaching assistant
01.01.2002–31.12.2002   
University of Ottawa, teaching assistant
 
 
Education
2005–2010   
University of Ottawa, PhD
2002–2005   
University of British Columbia, MSc
1998–2002   
University of Ottawa, BSc (hon)
 
 
Additional career information

Organiser of Tallinn University Brain Awareness Week, March 13th-19th, 2017

List of Events: art exhibition (patient art collection of the North Estonia Medical Centre psychiatry clinic); 2 sessions of talks by researchers from Tallinn University, Tallinn University of Technology, and University of Tartu; dissemination of daily Brain Fact/Tip on social media (Facebook, Twitter); workshops for elementary (2 classes) and high school students (2 classes); art exhibit with cloud imagery to encourage adults to be imaginative again and explain the phenomenon of pareidolia; film screenings (x3) relevant to mental health followed by Q&A with experts

Role: “Brain behind Brain Awareness Week”; Organiser, Concept and Creative Designer
Content creation: Brain Fact and Tips for dissemination on social media; workshop on subject of brain anatomy, optical illusions, pareidolia, and selective attention for elementary school students; text explaining the phenomenon of pareidolia
Other Tasks: Recruitment of volunteers, selection of films and recruitment of experts for Q&A session following screenings, Contact and recruitment of researchers for lecture series, creation of English language posters and postering, creation of English version of website (content only, no upload);

Teaching activities:
(2017) Guest Lecturer in Psycholinguistics GRT7304, School of Humanities, Tallinn University / Lecture Title: On learning and memory / Concept and creation of a lecture on the neuroanatomy and mechanisms of learning & memory geared toward students of translation studies.
(2014) Lecturer in Cellular and Behavioral Genetics WPM4, Institute for Molecular Psychiatry, University of Bonn / Lecture Title: Transcriptional Regulation of Gene Expression
(2011-2013) Lecturer and Practical Laboratory Supervisor in Cellular and Behavioral Genetics WPM4, Institute for Molecular Psychiatry, University of Bonn / Lecture Title: Transcriptional Regulation of Gene Expression / Description: This lecture pertained to the basic mechanisms of gene transcription with focus on regulatory control, epigenetics, and transcript stability. The practical laboratory session consisted of reverse transcription of mRNA into cDNA using oligo(dT) priming followed by real-time PCR using TaqMan Gene Expression Assays and data analysis of results. An overview of the background theory, methodology, data analysis and interpretation were also given in written course material that I devised.
(2010) Lecturer for Brain Awareness Week with the Society for Neuroscience, Ottawa Chapter / Topic: The brain and drugs of abuse
(2009) Teaching Assistant in BPS4900 B – Seminar, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks:
attend student presentations on assigned journal articles and to provide questions, feedback and an evaluation of the students’ presentation skills
(2008) Laboratory Demonstrator for BCH2333 (English) and BCH2733 (French) – Introduction to Biochemistry/Laboratoire de Biochimie I, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and to correct lab reports. / Experiment: Bligh and Dyer lipid extraction and visualization using 2D thin layer chromatography
(2007) Laboratory Demonstrator for BCH2733 – Laboratoire de Biochimie I, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and to correct lab reports. / Experiment: Bligh and Dyer lipid extraction and visualization using 2D thin layer chromatography
(2006) Laboratory Demonstrator for BCH3356 – Molecular Biology Laboratory, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and correct lab reports / Experiments: isolation of total RNA using Tri-Reagent, isolation of poly(A)+ RNA via oligo-d(T) column, RT-PCR, T/A cloning into pBluescript vector, miniprep bacterial plasmid isolation, in vitro transcription/translation, site-directed mutagenesis, endonuclease restriction digest & agarose gel electrophoresis, Northern, Southern, and Western blotting.
(2004) Tutorial Lecturer for the Summer Science 101 Program
Faculty of Science, University of British Columbia (August 4th, 2004) / Topic: Human Physiology
(2002) Laboratory Demonstrator for BCH 2736 – Laboratoire de Biochimie I, Department of Biochemistry, Faculty of Science, University of Ottawa / Tasks: supervise students during the lab sessions, answer questions during and following the session and to correct lab reports. / Experiment: Bligh and Dyer lipid extraction and visualization using 2D thin layer chromatography ;

Supervised Staff:
(2013) Blanca Randel, Biological Technical Assistant, Institute for Molecular Psychiatry, University of Bonn;

Supervised Students:
(2012) Katharina Schulenberg (Master’s rotation student, 8 weeks, University of Bonn) / Project: Determination of glial cell number in CB2-/- mice
(2011) Michael Saynisch (Bachelor trainee, 2 weeks, University of Bonn) / Project: Immunostaining of synapsin1 in D-amino acid oxidase overexpressing mice trained in a Morris Water Maze
(2010) Chloé Corbeil (summer student, 16 weeks, University of Ottawa) / Project: Immunostaining and in situ hybridization of LY receptor in mouse brain
(2009) Luca Giurgea (Bachelor’s Honours Thesis, 8 months, University of Ottawa) / Project: Characterization of kainic-acid induced injury in connexin29/32 double-null mutant mice;
Organiser of Tallinn University Brain Awareness Week, March 12th-18th, 2018

List of Events: "The Brain as Art" exhibition (March 5 - April 15th) ; lecture series with researchers from Tallinn University, University of Tartu, Uppsala University; dissemination of daily Brain Fact/Tip on social media (Facebook, Twitter); workshops for elementary and high school students; art exhibit with cloud imagery to encourage adults to be imaginative again and explain the phenomenon of pareidolia

Role: Organiser, concept and creative designer, presenter of student workshops, host of lecture series
Content creation: Brain Fact and Tips for dissemination on social media; custom workshops based on student questions for Grade 3 and Grade 9 students; creation of art exhibit pieces based on research own work;

Qualifications

 
 
Honours & awards
2013, Sophie Imbeault, Start-up funding for research groups, 54 820€ (grant covers the salary of a technician and consumables for 1 year), University of Bonn Faculty of Medicine BONFOR research funding. (Postdoctoral, competitive award)
2009, Sophie Imbeault, Fisher Scientific Faculty of Medicine Doctoral Excellence Award, 555CAD. (Doctoral, competitive award)
2007, Sophie Imbeault, Ontario Graduate Scholarship in Science in Technology (with support from the Parkinson Research Consortium and Centre for Stroke Recovery), 42 000CAD for 3 years (2007-2010). (Doctoral, competitive award)
2005, Sophie Imbeault, University of Ottawa Excellence Scholarship, value of tuition (approx. 33 000CAD over 5 years, 2005-2010). (Doctoral, non-competitive award)
2005, Sophie Imbeault, National Science and Engineering Research Council (NSERC) Postgraduate Scholarship, 42 000 CAD over 2 years (2005-2007). (Doctoral, competitive award)
2005, Sophie Imbeault, University of Ottawa Strategic Areas of Development Award, 6 000CAD. (Doctoral, non-comptetitive award)
2004, Sophie Imbeault, NSERC Postgraduate Scholarship, 17 300CAD for one year. (Master's, competitive award)
2003, Sophie Imbeault, Michael Smith Foundation for Health Research Master's Trainee Award, top up award of 19 400CAD + 5 000CAD research and travel for 2 years (2003-2005). (Master's, competitive award)
2003, Sophie Imbeault, Canada Graduate Scholarship, 17 500 CAD for one year. (Master's, competitive award)
2002, Sophie Imbeault, University of British Columbia Faculty of Graduate Studies Graduate Entrance Scholarship, 3 000CAD. (Master's, non-competitive award)
2002, Sophie Imbeault, Graduated B.Sc. (Honours) Summa Cum Laude
2001, Sophie Imbeault, NSERC Undergraduate Student Research Award, 5 000CAD. (Bachelor's, competitive award)
1998, Sophie Imbeault, University of Ottawa Admission Scholarship, 10 000CAD over 4 years (1998-2002). (Bachelor's, non-competitive award)
1998, Sophie Imbeault, NavCanada Scholarship, 6 000CAD over 4 years (1998-2002). (Bachelor's, competitive award)
1998, Sophie Imbeault, Dean's Honour List, 4 years (1998 - 2002).
 
 
Field of research
FIELD OF RESEARCH: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS SPECIALITY: B210 Histology, cytochemistry, histochemistry, tissue culture
 
 
Additional information
Research Projects:

(08/2014-09/2016 ) Postdoctoral Fellow in Psychoneuroimmunology at Karolinska Institutet (Sweden), Supervisor: Dr. Sophie Erhardt

Projects investigate the role of the kynurenine pathway, and kynurenic acid in particular, in rodent models of psychiatric disorders. Previous research in the laboratory has shown elevated kynurenic acid levels in cerebrospinal fluid of schizophrenia patients. I use pharmacological and transgenic mouse models to manipulate the kynurenine pathway and assess the impact of these changes on cognitive function and psychosis-related behaviours. The aim is to validate these models and use them to discover and test novel therapeutics.

(09/2010 – 03/2014) Postdoctoral Research Fellow at the University of Bonn (Germany), Supervisor: Prof. Dr. Andreas Zimmer

Research Project 1: Effects of adolescent cannabis consumption on brain maturation and psychosis

This project looked at the effect of cannabis administration in adolescence on psychosis-related behaviours in adulthood and the possible underlying mechanisms. Using a behavioural testing panel relevant to schizophrenia, deficits were found in tests reflecting negative and cognitive but not positive symptoms of schizophrenia. Microarray analysis revealed differentially expressed gene sets between animals immediately after treatment (P28) and after a 12 week washout period (P112) suggesting cannabis not only alters long-term gene expression but also brain development.

Research Project 2 : Characterization of D-amino oxidase (DAO) overexpressing mice

Increased expression and activity of DAO has been observed in post-mortem schizophrenia patient samples. We created a transgenic mouse line overexpressing DAO in astrocytes (hGFAP-DAO) and backbred it onto a C57Bl/6J background strain. These mice show decreased D-serine levels in multiple brain regions including the hippocampus. A behavioural testing panel revealed a slight increase in memory flexibility in DAO overexpressing mice during reversal training in a Morris Water Maze but no other significant behavioural phenotype.

(05/2005 – 05/2010) Ph.D. Biochemistry at the University of Ottawa (Canada), Supervisor: Dr. Steffany A.L. Bennett
Thesis: Connexin-mediated regulation of gliogenesis

Novel connexin protein expression was assessed in progenitor cells within the hippocampal formation or from hippocampal-derived progenitors in vitro. Localization of connexin proteins to novel cell types using co-labeling was shown. Phenotypic analysis of progenitor cell type, proliferation and specification were carried out both in vitro and in vivo and demonstrated a role for connexin-mediated regulation of gliogenesis within the hippocampus.

(09/2002 – 05/2005) M.Sc. Neuroscience at the University of British Columbia (Canada), Supervisor: Dr. Timothy H. Murphy
Thesis: Overexpression of Nrf2 via viral-mediated gene transfer in vivo

Following optimization of viral dosage and expression, a viral-vector expressing Nrf2, which is involved in upregulation of antioxidant defenses, was delivered to the striatum via stereotactic injection in a neurodegeneration model using the mitochondrial toxin 3-nitropropionic acid. Nrf2 overexpression lead to reduced volume loss as determined by Nissl staining, reduced gliosis and reduced neuronal loss.

(09/1998 – 05/2002) B.Sc. Hon. Biochemistry, University of Ottawa (Canada), Summa cum Laude
Honours Thesis: Effect of ectopic expression of GPR4 on viability, proliferation, and differentiation of PC12 cells – a role for sphingosylphosphocholine

This honours thesis project sought to identify ligands for the then-orphan receptor GPR4. A GPR4 construct was transfected into the PC12 cell-line and various ligands tested on survival, proliferation, and differentiation of the cells.

Publications

Category
Year
Publication
 
1.1.
2017
1.1.
2016
1.1.
2016
1.1.
2016
5.2.
2016
5.2.
2015
5.2.
2014
1.1.
2013
5.2.
2011
1.2.
2010
1.1.
2009
1.1.
2005
1.1.
2002
16.04.2018
  • Leitud 2 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
1.1.7.4.1.TF5916 (TLÜ uuringufondi nõukogu 25. novembri 2016. aasta koosoleku otsus nr 9/16)Tallinna Ülikooli loodus- ja terviseteaduste instituudi molekulaarteaduste labori proovimaterjali eeltöötluse metoodika kaasajastamine ja arendamine21.11.201630.01.2017Margit KaldmäeTallinna Ülikool, Loodus- ja terviseteaduste instituut8 000,00 EUR
MUUTF1515 (TLÜ senati teaduskomisjoni istungi protokoll 20.04.2015 nr 9)TLÜ käitumis- ja neuroteaduste tippkeskus 01.05.201531.12.2020Ruth ShimmoTallinna Ülikool, Matemaatika ja Loodusteaduste Instituut138 000,00 EUR