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Tõnis Org

https://www.etis.ee/CV/Tõnis_Org/eng
6.11.1979
737 5034
tonis.org@ut.ee
E-8596-2010

Career

Institutions and positions
01.09.2021–31.08.2023   
University of Tartu, Faculty of Science and Technology, Institute of Genomics, Associate Professor of Bioinformatics and Medical Genomics (0,30)
01.01.2021–...   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Associate Professor of Biotechnology (0,70)
01.01.2021–31.08.2021   
University of Tartu, Faculty of Science and Technology, Institute of Genomics, Associate Professor of Bioinformatics and Medical Genomics (0,30)
01.01.2020–31.12.2020   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Associate Professor of Biotechnology (0,70)
01.01.2020–31.12.2020   
University of Tartu, Institute of Genomics, Senior Research Fellow of Bioinformatics and Medical Genomics (0,30)
01.09.2017–31.12.2019   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Associate Professor of Biotechnology (1,00)
01.09.2016–31.12.2019   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Associate Professor of Molecular Biotechnology (1,00)
01.01.2016–31.08.2016   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Senior Research Fellow of Molecular Biotechnology (1,00)
01.09.2015–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Senior Research Fellow of Molecular Biotechnology (1,00)
01.09.2015–31.08.2017   
University of Tartu, Senior researcher (1,00)
21.05.2013–31.10.2014   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Research Fellow (1,00)
01.11.2011–20.05.2013   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Research Fellow (1,00)
2010–30.06.2015   
University of California, Los Angeles, Post-Doc (1,00)
01.09.2009–14.11.2010   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Research Fellow (1,00)
01.09.2004–31.08.2009   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Specialist (1,00)
01.01.2003–31.12.2003   
research fellow in GSF institute Munich, Germany
01.01.2002–31.12.2003   
Biotechnology company Asper Biotech
 
 
Education
2004–2010   
Ph.D student of medicine, Tartu University
2002–2004   
M.Sc student of gene technology, Tartu University
1998–2002   
undergraduate student of gene technology, Tartu University
 
 
R&D related managerial and administrative work
2019−...   
Vice president of Estonian Society of Human Genetics
2018−...   
Board member of Estonian Society of Human Genetics
2011−...   
Member of International Society of Stem Cell research
2010−...   
Member of Estonian Society of Allergologists and Immunologists
2000−...   
Member of Estonian Society of Human Genetics
2011−2015   
Member of American Heart Association
 
 
Additional information
- 2018, Internal opponent of Andres Ainelo's PhD thesis „Physiological effects of the Pseudomonas putida toxin GraT”, University of Tartu, Estonia
- 2018, Internal opponent of Laura Kasa's PhD thesis "Genome structural variation modulating the placenta and pregnancy maintenance" University of Tartu, Estonia
- 2018, Opponent of Karmen Vaiküll's MSc thesis „Actionable gene variants in Estonian Genome Center sample – identification of diseaseassociated variants and their possible use in genetic feedback” University of Tartu, Estonia
- 2016, Opponent of Kertu Liis Krigul MSc thesis „The role of DNA methylation in the pathogenesis of endometriosis” University of Tartu, Estonia
- 2016, Opponent of Kreete Lüll´s MSc thesis "Rare variant analysis to find genetic variants associated with polycystic ovary syndrome"
- 2010, Opponent of Urmo Võsa´s MSc thesis "The expression profiles of microRNAs in non-small cell lung cancer", University of Tartu, Estonia
- 2009, Opponent of Tormi Reinson´s MSc thesis „Nonspecific DNA melting activity of HPV-18 E1 activates CHK2 kinase” , University of Tartu, Estonia
- 2008, Opponent of Kaie Kirotar´s MSc thesis „Description of methylation changes in promoter regions of p53 target genes in non-small cell lung cancer and potential associations with mutations in TP53”, University of Tartu, Estonia




Qualifications

Academic degrees
Tõnis Org, Doctor's Degree, 2010, (sup) Pärt Peterson, Molecular function of the first PHD finger domain of Autoimmune Regulator protein, University of Tartu, Faculty of Medicine.
Tõnis Org, Research Master's Degree, 2004, (sup) Andres Metspalu, DNA kiipide kasutamine proteinuursete haiguste uurimiseks (DNA microarays for studying proteinuric diseases), University of Tartu, Faculty of Biology and Geography.
 
 
Honours & awards
2012, Tõnis Org, American Heart Association fellowship
2012, Tõnis Org, Leukemia and Lymphoma Society post-doctoral fellowship
2011, Tõnis Org, Mobilitas fellowship
2010, Tõnis Org, DoRa stipend
2010, Tõnis Org, National contest for scientific research - II prize for PhD thesis in health related studies
2009, Tõnis Org, DoRa stipend
2007, Tõnis Org, Kristjan Jaak travel stipend
2007, Tõnis Org, Best poster award at the annual meeting of Estonian society of human genetics, Pärnu
2007, Tõnis Org, Best presentation award at the Training Day for early stage researchers by the Euro-Thymaide Assembly, Toulouse
2007, Tõnis Org, Liisa Kolumbus stipend
2005, Tõnis Org, Young researcher fellowship from EMBO / FEBS
2003, Tõnis Org, Young Scientist fellowship The International School of Pediatric Sciences of the Scientific Institute, Genoa
2002, Tõnis Org, Young researcher fellowship from European Science Foundation
1998, Tõnis Org, stipend from Estonian Student Fund in USA
 
 

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2021
Krigul, Kertu Liis; Aasmets, Oliver; Lüll, Kreete; Org, Tõnis; Org, Elin (2021). Using fecal immunochemical tubes for the analysis of the gut microbiome has the potential to improve colorectal cancer screening. Scientific Reports, 11 (1). DOI: 10.1038/s41598-021-99046-w.
1.1.
2020
Teino, Indrek; Matvere, Antti; Pook, Martin; Varik, Inge; Pajusaar, Laura; Uudeküll, Keyt; Vaher, Helen; Trei, Annika; Kristjuhan, Arnold; Org, Tõnis; Maimets, Toivo (2020). Impact of AHR Ligand TCDD on Human Embryonic Stem Cells and Early Differentiation. International Journal of Molecular Sciences, 21 (23). DOI: 10.3390/ijms21239052.
1.1.
2020
Hensen, Kati; Pook, Martin; Sikut, Anu; Org, Tõnis; Maimets, Toivo; Salumets, Andres; Kurg, Ants (2020). Utilising FGF2, IGF2 and FSH in serum-free protocol for long-term in vitro cultivation of primary human granulosa cells. Molecular and Cellular Endocrinology, 510, 110816−110816. DOI: 10.1016/j.mce.2020.110816.
1.1.
2019
Org, Tõnis; Hensen, Kati; Kreevan, Rita; Mark, Elina; Sarv, Olav; Andreson, Reidar; Jaakma, Ülle; Salumets, Andres; Kurg, Ants (2019). Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP. PLoS ONE, 14 (11), e0225801. DOI: 10.1371/journal.pone.0225801.
1.1.
2018
Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. (2018). Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. Nature Communications, 9 (13, 3634). DOI: 10.1038/s41467-018-05573-y.
1.1.
2015
Org, T.; Duan, D.; Ferrari, R.; Montel-Hagen, A.; Van Handel, B.; Kerényi, MA.; Sasidharan, R.; Rubbi, L.; Fujiwara, Y.; Pellegrini, M.; Orkin, SH.; Kurdistani, SK.; Mikkola, HK. (2015). Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. The EMBO Journal, 34 (6), 759−777. DOI: 10.15252/embj.201490542.
1.1.
2014
Mishra, BP.; Zaffuto, KM.; Artinger, EL.; Org, T.; Mikkola, HK.; Cheng, C.; Djabali, M.; Ernst, P. (2014). The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Reports, 7 (4), 1239−1247. DOI: 10.1016/j.celrep.2014.04.015.
1.1.
2014
Goddard, LM.; Murphy, TJ.; Org, T.; Enciso, JM.; Hashimoto-Partyka, MK.; Warren, CM.; Domigan, CK.; McDonald, AI.; He, H.; Sanchez, LA.; Allen, NC.; Orsenigo, F.; Chao, LC.; Dejana, E.; Tontonoz, P.; Mikkola, HK.; Iruela-Arispe, ML. (2014). Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell, 156 (3), 549−562. DOI: 10.1016/j.cell.2013.12.025.
1.1.
2013
Goddard, LM; Ton, AN; Org, T; Mikkola, HK; Iruela-Arispe, ML (2013). Selective suppression of endothelial cytokine production by progesterone receptor. Vascular Pharmacology, 59, 36−43. DOI: 10.1016/j.vph.2013.06.001.
1.1.
2012
Van Handel, B; Montel-Hagen, A; Sasidharan, R; Nakano, H; Ferrari, R; Boogerd, CJ; Schredelseker, J; Wang, Y; Hunter, S; Org, T; Zhou, J; Li, X; Pellegrini, M; Chen, JN; Orkin, SH; Kurdistani, SK; Evans, SM; Nakano, A; Mikkola, HK (2012). Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell, 150 (3), 590−605. DOI: 10.1016/j.cell.2012.06.026.
1.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tõnis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics, 11, 642. DOI: 10.1186/1471-2164-11-642.
1.1.
2009
Chignola, F.; Gaetani, M.; Rebane, A.; Org, T.; Mollica, L.; Zucchelli, C.; Spitaleri, A.; Mannella, V.; Peterson, P.; Musco, G. (2009). The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Research, 37 (9), 2951−2961.
1.1.
2008
Peterson, P.; Org, T.; Rebane, A. (2008). Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nature Reviews Immunology, 8 (12), 948−957. DOI: 10.1038/nri2450.
1.1.
2008
Kisand, K.; Link, M.; Wolff, A.S. B.; Meager, A.; Tserel, L.; Org, T.; Murumägi, A.; Uibo, R.; Willcox, N.; Podkrajšek Trebušak, K.; Battelino, T.; Lobell, A.; Kämpe, O.; Perheentupa, J.; Krohn, K.; Scott, H.S.; Husebye, E.S.; Peterson, P. (2008). Interferon autoantibodies associated with AIRE-deficiency decrease the expression of IFN-stimulated genes. Blood, 112 (7), 2657−2666.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1783 (1), 74−83. DOI: 10.1016/j.bbamcr.2007.09.003.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376. DOI: 10.1038/embor.2008.11.
1.3.
2007
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U.; Mollica, L.; Musco, G.; Peterson, P. (2007). Autoimmuunsuse regulaator (AIRE) valgu PHD tsink sõrm seondub geeniekspressiooni aktiviseerimiseks mittemetüleeritud histoon H3K4-ga. Eesti Arst, 9, 685.
1.1.
2005
Lohmussaar, E.; Gschwendtner, A.; Mueller, JC.; Org, T.; Wichmann, E.; Hamann, G.; Meitinger, T.; Dichgans, M. (2005). ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke, 36 (4), 731−736.

Industrial property

22.03.2022

Tõnis Org

https://www.etis.ee/CV/Tõnis_Org/est
6.11.1979
737 5034
tonis.org@ut.ee

Teenistuskäik

Töökohad ja ametid
01.09.2021–31.08.2023   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, genoomika instituut, bioinformaatika ja meditsiinilise genoomika kaasprofessor (0,30)
01.01.2021–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut, biotehnoloogia kaasprofessor (0,70)
01.01.2021–31.08.2021   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, genoomika instituut, bioinformaatika ja meditsiinilise genoomika kaasprofessor (0,30)
01.01.2020–31.12.2020   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut, biotehnoloogia dotsent (0,70)
01.09.2017–31.12.2019   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut, biotehnoloogia dotsent (1,00)
01.09.2016–31.12.2019   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut, molekulaarse biotehnoloogia dotsent (1,00)
01.01.2016–31.08.2016   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut, molekulaarse biotehnoloogia vanemteadur (1,00)
01.09.2015–31.12.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, molekulaarse biotehnoloogia vanemteadur (1,00)
01.09.2015–31.08.2017   
Tartu Ülikool, Vanemteadur (1,00)
21.05.2013–31.10.2014   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, teadur (1,00)
01.11.2011–20.05.2013   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, teadur (1,00)
2010–30.06.2015   
Kalifornia Ülikool Los Angeles'es, Järeldoktor (1,00)
01.09.2009–14.11.2010   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, teadur (1,00)
01.09.2004–31.08.2009   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, laborispetsialist (1,00)
01.01.2003–31.12.2003   
teadustöö GSF instituudis Münhenis Saksamaal
01.01.2002–31.12.2003   
Biotechnology company Asper Biotech
 
 
Haridustee
2004–2010   
arstiteaduse doktorantuur, Tartu Ülikool
2002–2004   
magistratuur geenitehnoloogia erialal, Tartu Ülikool
1998–2002   
õpingud geenitehnoloogia erialal, Tartu Ülikool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2019−...   
Eesti Inimesegeneetika Ühingu asepresident
2018−...   
Eesti Inimesegeneetika Ühingu juhatuse liige
2011−...   
Rahvusvahelise Tüviraku Seltsi liige
2010−...   
Eesti Immunoloogide ja Allergoloogide Seltsi liige
2000−...   
Eesti Inimesegeneetika ühingu liige
2011−2015   
Ameerika Südeme Assotsatsiooni liige
 
 
Lisainfo
- 2018, Andres Ainelo doktoritöö „Pseudomonas putida toksiini GraT mõju bakteri füsioloogiale” siseoponent, Tartu Ülikool, Eesti
- 2018, Laura Kasaku doktoritöö "Genome structural variation modulating the placenta and pregnancy maintenance" siseoponent, Tartu Ülikool, Eesti
- 2018, Karmen Vaikülli magistritöö „Sekkumist võimaldavad geenivariandid TÜ Eesti Geenivaramu valimis – haigusseoselisuse tuvastamine ja võimalik kasutamine geneetilises tagasisides” oponent, Tartu Ülikool, Eesti
- 2016, Kertu Liis Kriguli magistritöö „DNA metülatsioonimustri roll endometriooni kujunemises” oponent, Tartu Ülikool, Eesti
- 2016, Kreete Lüll magistritöö "Harvade variantide analüüs polütsüstiliste munasarjade sündroomiga seotud geneetilisete variantide tuvastamiseks" oponent, Tartu Ülikool, Eesti
- 2010, Urmo Võsa magistritöö "MikroRNAde ekspressioonimustrid mitteväikerakulises kopsuvähis " oponent, Tartu Ülikool, Eesti
- 2009, Tormi Reinsoni magistritöö „HPV-18 E1 aktiveerib Chk2 kinaasi läbi mitte-spetsiifilise DNA kaksikheeliksi lahtisulatamise” opponent, Tartu Ülikool, Eesti
- 2008, Kaie Kirotari magistritöö "p53 märklaudgeenide promootoralade metülatsiooni muutuste kirjeldamine mitteväikerakulise kopsuvähi rakuliinidel ning muutuste potentsiaalsed seosed TP53 mutatsioonidega" oponent, Tartu Ülikool, Eesti

Kvalifikatsioon

Teaduskraadid
Tõnis Org, Doctor's Degree, 2010, (sup) Pärt Peterson, Molecular function of the first PHD finger domain of Autoimmune Regulator protein, University of Tartu, Faculty of Medicine.
Tõnis Org, Research Master's Degree, 2004, (sup) Andres Metspalu, DNA kiipide kasutamine proteinuursete haiguste uurimiseks (DNA microarays for studying proteinuric diseases), University of Tartu, Faculty of Biology and Geography.
 
 
Teaduspreemiad ja tunnustused
2012, Tõnis Org, AHA stipendium
2012, Tõnis Org, Leukeemia ja Lümfoomi Seltsi stipendium
2011, Tõnis Org, Mobilitase stipendium
2010, Tõnis Org, DoRa stipendium
2010, Tõnis Org, Riiklik teadustööde konkurss - II preemia terviseuuringute valdkonna doktoritööde katekoorias
2009, Tõnis Org, DoRa stipendium
2007, Tõnis Org, Kristjan Jaak reisistipendium
2007, Tõnis Org, Parima postri auhind Eesti inimesegeneetika aastakonverentsil Pärnus
2007, Tõnis Org, Parima ettekande auhind noorteadlaste treeningpäeval the Euro-Thymaide Assembly, Toulouse
2007, Tõnis Org, Liisa Kolumbuse stipendium
2005, Tõnis Org, noore teadlase stipendium EMBO / FEBS
2003, Tõnis Org, noore teadlase stipendium, The International School of Pediatric Sciences of the Scientific Institute, Genoa
2002, Tõnis Org, noore teadlase stipendium Euroopa Teadusfondilt
1998, Tõnis Org, stipendium Eesti Üliõpilaste toetusfondilt USAs

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2021
Krigul, Kertu Liis; Aasmets, Oliver; Lüll, Kreete; Org, Tõnis; Org, Elin (2021). Using fecal immunochemical tubes for the analysis of the gut microbiome has the potential to improve colorectal cancer screening. Scientific Reports, 11 (1). DOI: 10.1038/s41598-021-99046-w.
1.1.
2020
Teino, Indrek; Matvere, Antti; Pook, Martin; Varik, Inge; Pajusaar, Laura; Uudeküll, Keyt; Vaher, Helen; Trei, Annika; Kristjuhan, Arnold; Org, Tõnis; Maimets, Toivo (2020). Impact of AHR Ligand TCDD on Human Embryonic Stem Cells and Early Differentiation. International Journal of Molecular Sciences, 21 (23). DOI: 10.3390/ijms21239052.
1.1.
2020
Hensen, Kati; Pook, Martin; Sikut, Anu; Org, Tõnis; Maimets, Toivo; Salumets, Andres; Kurg, Ants (2020). Utilising FGF2, IGF2 and FSH in serum-free protocol for long-term in vitro cultivation of primary human granulosa cells. Molecular and Cellular Endocrinology, 510, 110816−110816. DOI: 10.1016/j.mce.2020.110816.
1.1.
2019
Org, Tõnis; Hensen, Kati; Kreevan, Rita; Mark, Elina; Sarv, Olav; Andreson, Reidar; Jaakma, Ülle; Salumets, Andres; Kurg, Ants (2019). Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP. PLoS ONE, 14 (11), e0225801. DOI: 10.1371/journal.pone.0225801.
1.1.
2018
Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. (2018). Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. Nature Communications, 9 (13, 3634). DOI: 10.1038/s41467-018-05573-y.
1.1.
2015
Org, T.; Duan, D.; Ferrari, R.; Montel-Hagen, A.; Van Handel, B.; Kerényi, MA.; Sasidharan, R.; Rubbi, L.; Fujiwara, Y.; Pellegrini, M.; Orkin, SH.; Kurdistani, SK.; Mikkola, HK. (2015). Scl binds to primed enhancers in mesoderm to regulate hematopoietic and cardiac fate divergence. The EMBO Journal, 34 (6), 759−777. DOI: 10.15252/embj.201490542.
1.1.
2014
Mishra, BP.; Zaffuto, KM.; Artinger, EL.; Org, T.; Mikkola, HK.; Cheng, C.; Djabali, M.; Ernst, P. (2014). The histone methyltransferase activity of MLL1 is dispensable for hematopoiesis and leukemogenesis. Cell Reports, 7 (4), 1239−1247. DOI: 10.1016/j.celrep.2014.04.015.
1.1.
2014
Goddard, LM.; Murphy, TJ.; Org, T.; Enciso, JM.; Hashimoto-Partyka, MK.; Warren, CM.; Domigan, CK.; McDonald, AI.; He, H.; Sanchez, LA.; Allen, NC.; Orsenigo, F.; Chao, LC.; Dejana, E.; Tontonoz, P.; Mikkola, HK.; Iruela-Arispe, ML. (2014). Progesterone receptor in the vascular endothelium triggers physiological uterine permeability preimplantation. Cell, 156 (3), 549−562. DOI: 10.1016/j.cell.2013.12.025.
1.1.
2013
Goddard, LM; Ton, AN; Org, T; Mikkola, HK; Iruela-Arispe, ML (2013). Selective suppression of endothelial cytokine production by progesterone receptor. Vascular Pharmacology, 59, 36−43. DOI: 10.1016/j.vph.2013.06.001.
1.1.
2012
Van Handel, B; Montel-Hagen, A; Sasidharan, R; Nakano, H; Ferrari, R; Boogerd, CJ; Schredelseker, J; Wang, Y; Hunter, S; Org, T; Zhou, J; Li, X; Pellegrini, M; Chen, JN; Orkin, SH; Kurdistani, SK; Evans, SM; Nakano, A; Mikkola, HK (2012). Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell, 150 (3), 590−605. DOI: 10.1016/j.cell.2012.06.026.
1.1.
2010
Tserel, Liina; Kolde, Raivo; Rebane, Ana; Kisand, Kai; Org, Tõnis; Peterson, Hedi; Vilo, Jaak; Peterson, Pärt (2010). Genome-wide promoter analysis of histone modifications in human monocyte-derived antigen presenting cells. BMC Genomics, 11, 642. DOI: 10.1186/1471-2164-11-642.
1.1.
2009
Chignola, F.; Gaetani, M.; Rebane, A.; Org, T.; Mollica, L.; Zucchelli, C.; Spitaleri, A.; Mannella, V.; Peterson, P.; Musco, G. (2009). The solution structure of the first PHD finger of autoimmune regulator in complex with non-modified histone H3 tail reveals the antagonistic role of H3R2 methylation. Nucleic Acids Research, 37 (9), 2951−2961.
1.1.
2008
Peterson, P.; Org, T.; Rebane, A. (2008). Transcriptional regulation by AIRE: molecular mechanisms of central tolerance. Nature Reviews Immunology, 8 (12), 948−957. DOI: 10.1038/nri2450.
1.1.
2008
Kisand, K.; Link, M.; Wolff, A.S. B.; Meager, A.; Tserel, L.; Org, T.; Murumägi, A.; Uibo, R.; Willcox, N.; Podkrajšek Trebušak, K.; Battelino, T.; Lobell, A.; Kämpe, O.; Perheentupa, J.; Krohn, K.; Scott, H.S.; Husebye, E.S.; Peterson, P. (2008). Interferon autoantibodies associated with AIRE-deficiency decrease the expression of IFN-stimulated genes. Blood, 112 (7), 2657−2666.
1.1.
2008
Liiv, I.; Rebane, A.; Org, T.; Saare, M.; Maslovskaja, J.; Kisand, K.; Juronen, E.; Valmu, L.; Bottomley, M.J.; Kalkkinen, N.; Peterson, P. (2008). DNA-PK contributes to the phosphorylation of AIRE: Importance in transcriptional activity. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1783 (1), 74−83. DOI: 10.1016/j.bbamcr.2007.09.003.
1.1.
2008
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U., Mollica, L.; Bottomley, M.; Musco, G.; Peterson, P. (2008). The Autoimmune Regulator PHD finger binds non-methylated Histone H3K4 to activate gene expression. EMBO Reports, 9 (4), 370−376. DOI: 10.1038/embor.2008.11.
1.3.
2007
Org, T.; Chignola, F.; Hetényi, C.; Gaetani, M.; Rebane, A.; Liiv, I.; Maran, U.; Mollica, L.; Musco, G.; Peterson, P. (2007). Autoimmuunsuse regulaator (AIRE) valgu PHD tsink sõrm seondub geeniekspressiooni aktiviseerimiseks mittemetüleeritud histoon H3K4-ga. Eesti Arst, 9, 685.
1.1.
2005
Lohmussaar, E.; Gschwendtner, A.; Mueller, JC.; Org, T.; Wichmann, E.; Hamann, G.; Meitinger, T.; Dichgans, M. (2005). ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke, 36 (4), 731−736.

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22.03.2022

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  • Found 11 results
ProgramTypeNumberNameProject startProject endPrincipal investigatorInstitutionFinancing
ETFETF6663AIRE gene expression in dendritic cells and influence on chemokine production01.01.200631.12.2009Pärt PetersonUniversity of Tartu; University of Tartu, Faculty of Medicine53 213,99 EUR
ETFETF6490AIRE as transcriptional regulator01.01.200531.12.2008Ana RebaneUniversity of Tartu, Faculty of Medicine26 270,25 EUR
1.1.5.3.4.1.5.SP1GI20429T (MOBEC008)cGEM - Centre for Genomics, Evolution and Medicine01.09.202031.10.2022Jon Anders ErikssonUniversity of Tartu, Institute of Genomics200 000,00 EUR
MUU PLTGI22904 The Legacy of Past Genetic Adaptations for Present-day Health in the Estonian Population01.02.202231.01.2023Jon Anders ErikssonUniversity of Tartu, Faculty of Science and Technology, Institute of Genomics50 000,00 EUR
ETFETF8169Epigenetic regulations in immune tolerance01.01.201031.12.2012Pärt PetersonUniversity of Tartu, Faculty of Medicine57 542,29 EUR
1.2.3.4.MP1GI18418R (810645)Center for Genomics, Evolution and Medicine01.09.201831.08.2023Mait MetspaluUniversity of Tartu, Institute of Genomics1 835 000,00 EUR
1.2.3.4.MMVCM18418R (810645)Center for Genomics, Evolution and Medicine01.09.201831.08.2023Mait MetspaluUniversity of Tartu665 000,00 EUR
PUT; PUT_SPPUT1177Enhancer RNAs in regulation of hematopoietic development01.01.201630.04.2020Tõnis OrgUniversity of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology187 200,00 EUR
SFSF0182582As03Human Genome II01.01.200331.12.2007Andres MetspaluUniversity of Tartu, Faculty of Biology and Geography328 505,88 EUR
MJDMJD284Mechanisms of Scl/Tal1 dependent gene activation and repression during mesoderm diversification01.11.201131.10.2014Tõnis OrgUniversity of Tartu, Faculty of Medicine94 080,00 EUR
SFSF0180021s07Thymic tolerance mechanisms01.01.200731.12.2012Pärt PetersonUniversity of Tartu, Faculty of Medicine527 814,01 EUR