Valdur Saks

https://www.etis.ee/CV/Valdur_Saks/est

Sünniaeg

3.09.1943

Telefon

639 8363

Telefon

644 8643

E-post

Palun lisage siia ainult üks aadress. Sellele meiliaadressile saadetakse ETISe teated (nt rahastusotsused, andmete kinnitamisega seotud info).

valdur.saks@ujf-grenoble.fr

Teenistuskäik

Töökohad ja ametid

Eesti TA Küberneetika Instituut, noorem teaduslik töötaja 1970-1971

Moskva Ülikooli keemiateaduskonna noorem teaduslik töötaja 1971-1972

Moskva Kardiokeskuse vanem teaduslik töötaja 1972-1981

Moskva Kardiokeskuse bioenergeetika laboratooriumi juhataja 1981-1993

Eesti TA Keemilise ja Bioloogilise Füüsika Instituudi Bioenergeetika laboratooriumi juhataja k.t. - 1993 kuni tänaseni

Grenoble'i Joseph Fourier Ülikooli Südameraku füsioloogia laboratooriumi titulaarprofessor, 1994 - kuni tanaseni

Töötanud lühiajaliselt koostööprogrammide läbiviimisel: University of Pennsylvania, Philadelphia, USA, 1975-1978

John Hopkinsi Ülikoolis Baltimore'is, USA, 1978-1981

Universite Paris-Sud, Orsay, France korduvalt aastatel 1981-1993

01.01.2015–31.12.2016

Keemilise ja Bioloogilise Füüsika Instituut, Vanemteadur (0,10)

01.09.2007–31.12.2014

Keemilise ja Bioloogilise Füüsika Instituut, Juhtivteadur (0,50)

1996–01.09.2007

Keemilise ja Bioloogilise Füüsika Instituut, Vanemteadur (0,50)

Haridustee

kõrgem, Moskva Ülikool

Teadusorganisatsiooniline ja -administratiivne tegevus

2010−...

ajakirja PLoS One akadeemiline toimetaja

1993 Eesti Teaduste Akadeemia akadeemik

International Society for Heart Research, Täitevkomitee liige

American Heart Association, Basic Science Council

International Federation of Cardiological Societies

Venemaa Biokeemia Ühing

American Physiological Society

American Biophysical Society

Osavõtt väljaannete toimetamisest:

Journal of Molecular and Cellular Cardiology, USA

Il Cuore, Italy

Cardioscience, Italy

Journal of Physiology, Poland

Kvalifikatsioon

Teaduskraadid

Valdur Saks, doktorikraad, 1971, (juh) I. V. Berezin, Oksüdeeriva fosforüleerimise süsteemi stabiliseerimine tema funktsioneerimisel, Moskva Ülikool.

Teaduspreemiad ja tunnustused

2008, Valdur Saks, Riigi teaduspreemia uurimuste tsükli „ Molekulaarne süsteemne bioenergeetika” eest

2006, Valdur Saks, Valgetähe orden, 4 . klass

1988, Valdur Saks, NSVL Riiklik Preemia 1978ÜRO ja UNICEF'i rahvusvaheline preemia "Research for Development"

Teadustöö põhisuunad

ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia

Lisainfo

Keemiakandidaat Bioloogiadoktor
1971 Moskva Ülikoolis
1981Moskva Kardiokeskus

Lõppenud projektid

Programm	Number	Pealkiri	Projekti algus	Projekti lõpp	Vastutav täitja	Asutused	Finantseerijapoolne rahastamine
Institutsionaalne uurimistoetus (IUT)	IUT23-1	Integreeritud energeetilise metabolismi regulatsioonimehhanismid kasvaja- ning lihasrakkudes.	01.01.2014	31.12.2019	Tuuli Käämbre	Keemilise ja Bioloogilise Füüsika Instituut	1 013 400 EUR
Eesti Teadusfondi uurimistoetus (ETF)	ETF8987	Vähirakkude bioenergeetilise profiili määramine diagnostikas ja ravis.	01.01.2012	31.12.2015	Tuuli Käämbre	Keemilise ja Bioloogilise Füüsika Instituut	69 600 EUR

Juhendamisel väitekirjad

Pealkiri	Juhendatav	Kraad	Juhendaja	Kaitsmise staatus	Kaitsmise aasta	Asutused
Soolevähi metaboolne remodelleerimine: muutused energiavoogudes	Kaldma, Andrus	doktorikraad	Tuuli Käämbre; Natalja Timohhina	Kaitstud	2017	Tallinna Tehnikaülikool

Andrus Kaldma, doktorikraad, 2017, (juh) Tuuli Käämbre; Natalja Timohhina, Soolevähi metaboolne remodelleerimine: muutused energiavoogudes, Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond.

Juhendatud väitekirjad

Pealkiri	Juhendatav	Kraad	Juhendaja	Kaitsmise staatus	Kaitsmise aasta	Asutused
Structural and Functional Studies of Mitochondrial Respiration Regulation in Muscle Cells	Varikmaa, Minna	doktorikraad	Valdur Saks; Madis Metsis	Kaitstud	2013	Tallinna Tehnikaülikool
Molecular System Bioenergetics of Cardiac Cells: Quantitative Analysis of Structure-Function Relationship	Kersti Tepp	doktorikraad	Raivo Vilu; Valdur Saks	Kaitstud	2011	Tallinna Tehnikaülikool
Molecular system bioenergetics of the heart cells: Mitochondrial Interactosome	Timohhina, Natalja	doktorikraad	Valdur Saks; Tuuli Käämbre	Kaitstud	2011	Tallinna Ülikool
Integrated and Organized Cellular Bioenergetic Systems in Heart and Brain	Grellier, Tiia	doktorikraad	Raivo Vilu; Valdur Saks	Kaitstud	2007	Tallinna Tehnikaülikool
Intracellular energetic unit: structural and functional aspects	Käämbre, Tuuli	doktorikraad	Valdur Saks; Enn Seppet	Kaitstud	2004	Tartu Ülikool
Rakusisese struktuuri osa mitokondriaalse hingamise regulatsioonis.	T.Andrienko	doktorikraad	Valdur Saks	Kaitstud	2003
Étude du contrôle de la respiration mitochondrial des cellules musculaires - rôle de la membrane externe	Tiivel, Toomas	doktorikraad	Valdur Saks; André Rossi; Enn Seppet	Kaitstud	2002	Tallinna Tehnikaülikool
Fosfokreatiini sünteesi seostuse mehhanismid glükolüütiliste reaktsioonidega ja mitokondriaalse oksüdatiivse fosforüülimisega lihasrakkudes	Seppet, Enn	doktorikraad	Valdur Saks	Kaitstud	1980

Publikatsioonid

Klass

Aasta

Publikatsioon

1.1.

2015

Guzun, Rita; Kaambre, Tuuli; Bagur, Rafaela; Grichine, Alexei; Usson, Yves; Varikmaa, Minna; Anmann, Tiia; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Boucher, Francois; Dos Santos, Pierre; Schlattner, Uwe; Wallimann, Theo; Kuznetsov, Andrey; Dzeja, Petras; Aliev, Mayis; Saks, Valdur (2015). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica, 213 (1), 84−106. DOI: 10.1111/apha.12287.

1.1.

2014

Anmann, Tiia; Varikmaa, Minna; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor, Chekulayev, Vladimir'; Saks, Valdur; Kaambre, Tuuli. (2014). Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1837 (8), 1350−1361. DOI: 10.1016/j.bbabio.2014.03.015.

1.1.

2014

Varikmaa, Minna; Bagur, Rafaela; Käämbre, Tuuli; Grichine, Alexei; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Metsis, Madis; Boucher, Francois; Saks, Valdur; Kuznetsov, Andrey V.; Guzun, Rita (2014). Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1837 (2), 232−245. DOI: 10.1016/j.bbabio.2013.10.011.

1.1.

2014

Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Shevchuk, Igor; Tepp, Kersti; Kaldma, Andrus; Koit, Andre; Saks, Valdur; Kaambre, Tuuli (2014). Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. Journal of Bioenergetics and Biomembranes, 46 (1), 17−31. DOI: 10.1007/s10863-013-9529-5.

3.1.

2014

Saks, V.; Schlattner, U.;Tokarska-Schlattner, M.; Wallimann, T.; Bagur, R.; Zorman, S.; Pelosse, M.; Dos Santos, P.; Boucher, F; Kaambre, T.; Guzun, R. (2014). Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine,Phosphotransfer Pathways, and AMPK Signaling. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (Ed.). " SYSTEMS BIOLOGY OF METABOLIC AND SIGNALING NETWORKS: ENERGY, MASS AND INFORMATION TRANSFER." (261−320). . Heidelberg: Springer-Verlag Berlin. (Springer Series in Biophysics; 16). DOI: 10.1007/978-3-642-38505-6_11.

3.1.

2014

Aon, M. A.; Lloyd, D.; Saks, V. (2014). From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (Ed.). Systems Biology of Metabolic and Signaling Networks (3−17). . Springer-Verlag Heidelberg. DOI: 10.1007/978-3-642-38505-6_1.

1.1.

2013

Kaambre, Tuuli; Chekulayev, Vladimir; Shevchuk, Igor; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Bagur, Rafaela; Klepinin, Aleksandr; Anmann, Tiia; Koit, Andre; Kaldma, Andrus; Guzun, Rita; Valvere, Vahur; Saks, Valdur (2013). Metabolic Control Analysis of Respiration in Human Cancer Tissue. Frontiers in Physiology, 4, 1−6. DOI: 10.3389/fphys.2013.00151.

1.1.

2013

Varikmaa, M.; Guzun, R.; Grichine, A.; Gonzalez-Granillo, M;, Usson, Y.: Boucher, F.; Kaambre, T.; Saks, V. (2013). Matters of the heart in bioenergetics: mitochondrial fusion into continuous reticulum is not needed for maximal respiratory activity. Journal of Bioenergetics and Biomembranes, 45 (4), 319−331. DOI: 10.1007/s10863-012-9494-4.

1.3.

2013

Käämbre, Tuuli; Koit, Andre; Ševtšuk, Igor; Tšekulajev, Vladimir; Tepp, Kersti; Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur (2013). Uusi suundi kasvajate energiametabolismi uuringutes. Eesti Arst, 92 (5), 261−267.

1.3.

2013

Anmann, Tiia; Varikmaa, Minna; Tepp, Kersti; Timohhina, Natalja; Ševtšuk, Igor; Tšekulajev, Vladimir; Saks, Valdur; Käämbre, Tuuli (2013). Südamerakkude sünnijärgse arengu bioenergeetilised aspektid: struktuuri ja funktsiooni vaheliste seoste väljakujunemine. Eesti Arst, 92 (7), 372−381.

3.5.

2013

Käämbre, T., Ševtšuk, I., Saks, V. (2013). Süsteemibioloogia ja süsteemibioenergeetika: kuidas uurida struktuuri ja funktsiooni vahelisi seoseid. Teoreetilise bioloogia kevadkool: 39. Teoreetilise bioloogia kevadkool, Mustjõe, Aegviidu. Toim. Sõber, Virve; Laanisto, Lauri; Öpik, Maarja; Tammaru, Toomas; Kull, Kalevi. Tartu: Eesti Looduseuurijate Selts, 29−40. (Schola Biotheoretica; 39).

3.5.

2013

Varikmaa, M; Bagur, R; Metsis, M; Grichine, A; Tepp, K; Käämbre, T; Saks, V and Guzun, R. (2013). Fine-tuning mitochondria function by betaII tubulin in striated muscles. Barcelona BioMed Conference "The microtubule cytoskeleton in development and disease"..

5.1.

2013

Quetglas, RB; Karu-Varikmaa, M; Tepp, K; Metsis, M; Kaambre, T; Grichine, A; Boucher, F; Saks, V; Guzun, R (2013). Regulation of Respiration in Permeabilized Muscle Cells: Apparent KM for ADP Shows the Mitochondrial Outer Membrane Permeability. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. , 447A−448A. (2; 1).

5.1.

2013

Karu, M ; Bagun, R ; Metsis, M ; Grichine, A; Tepp, K ; Kaambre, T; Saks, V; Guzun, R (2013). Unpolymerized beta II Tubulin in Regulation of Mitocondrial Function in Muscle Cells. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. , 302A−302A. (2; 1).

5.1.

2013

Koit, Andre; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Bogovskaja, Jelena; Valvere, Vahur Saks, Valdur; Kaambre, Tuuli (2013). Bioenergetic profiling of human breast cancer: unusual organisation of the respiratory chain. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 922. DOI: 10.1016/j.mito.2013.07.064.

5.1.

2013

Kaldma, Andrus; Koit, Andre; Shevchuk, Igor; Chekulayev, Vladimir; Tepp, Kersti; Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur; Kaambre, Tuuli (2013). Regulation of respiration of human colorectal cancer: application of Metabolic Control Analysis. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 900.

5.1.

2013

Shevchuk, Igor; Koit, Andre; Kaldma, Andrus; Timohhina, Natalja; Chekulayev, Vladimir; Tepp, Kersti; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur; Kaambre, Tuuli (2013). Comparative aspects of bioenergetic profiling of tumor clinical material and cell cultures. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 907. DOI: 10.1016/j.mito.2013.07.027.

1.1.

2012

Guzun, R.; Aguilaniu, B.; Wuyam, B.; Mezin, P.; Koechlin-Ramonatxo, C.; Auffray, C.; Saks, V.; Pison, C. (2012). Effects of training at mild exercise intensities on quadriceps muscle energy metabolism in patients with chronic obstructive pulmonary disease. Acta Physiologica, 205 (2), 236−246.10.1111/j.1748-1716.2011.02388.x.

1.1.

2012

Tokarska-Schlattner, M., Epand, R.F., Meiler, F et al.. (2012). Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects. PLoS ONE, 7, e43178.

1.1.

2012

Kuznetsov, A.V.; Guzun, R.; Boucher, F.; Bagur, R.; Käämbre, T.; Saks, V. (2012). Mysterious Ca2+-independent muscular contraction: deja vu. Biochemical Journal, 445, 333−336. DOI: 10.1042/BJ20120439.

1.1.

2012

Käämbre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Tepp, K.; Bogovskaja, J.; Kütner, R.; Valvere, V.; Saks, V. (2012). Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. Journal of Bioenergetics and Biomembranes, 44 (5), 539−558. DOI: 10.1007/s10863-012-9457-9.

1.1.

2012

Guzun, R.; Gonzalez-Granillo, M.; Karu-Varikmaa, M.; Grichine, A.; Usson, Y.; Käämbre, T.; Guerrero-Roesch, K.; Kuznetsov, A.; Schlattner, U.; Saks, V. (2012). Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1818, 1545−1554. DOI: 10.1016/j.bbamem.2011.12.034.

1.1.

2012

Gonzalez-Granillo, M.; Grichine, A.; Guzun, R.; Ussov, Y.; Tepp, K.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Kuznetsov, A.V.; Grimm, M.; Saks, V.; Käämbre, T. (2012). Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. Journal of Molecular and Cellular Cardiology, 52, 437−447. DOI: 10.1016/j.yjmcc.2011.07.027.

1.1.

2012

Saks, V.; Kuznetsov, A.V.; Gonzalez-Granillo, M.; Tepp, K.; Timohhina, N.; Karu-Varikmaa, M.; Käämbre, T.; Santos, P.D.; Boucher, F.; Guzun, R. (2012). Intracellular energetic Units regulate metabolism in cardiac cells. Journal of Molecular and Cellular Cardiology, 419−436. DOI: 10.1016/j.yjmcc.2011.07.015.

5.1.

2012

Tepp, K.; Kaambre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Valvere, V.; Saks, V. (2012). Comparative investigation of bioenergetic properties of human colorectal and breast cancer. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S136. (supplement to volume 1817).

5.1.

2012

Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Tepp, K.; Klepinin, A.; Saks, V.; Kaambre, T. (2012). Metabolic control analysis of integrated energy metabolism in permeabilized neuroblastoma cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S135. (supplement for volume 1817).

5.2.

2012

Timohhina, N.; Anmann, T.; Klepinin, A.; Tepp, K.; Shevchuk, I.; Käämbre, T.; Saks, V. (2012). Postnatal developments of rat heart: formation of intracellular energetic units. In New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. June 12-15, 2012; Hradec Kralove, Czech Republic, Hradec Kralove. , 40−40.

5.2.

2012

Tepp, K.; Timohhina, N.; Chekulayev, V.; Saks, V.; Kaambre, T.; Shevchuk, I. (2012). Control Analysis of Intracellular Energetic Unit in cardiac cell. In New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. June 12-15, 2012; Hradec Kralove, Czech Republic, Hradec Kralove. , 39−39.

5.2.

2012

Klepinin, A.; Karu-Varikmaa, M.; Shevchuk, I.; Chekulayev, V.; Tepp, K.; Saks, V. and Käämbre, T. (2012). Intracellular energetic units organized by tubulin. New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. Hradec Kralove, Czech Republic, Hradec Kralove, June 12-15, 2012. , 39-40−40.

1.1.

2011

Aliev, M., Guzun, R., Karu-Varikmaa, M., Kaambre, T., Wallimann, T., Saks, V. (2011). Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modeling. International Journal of Molecular Sciences, 12 (12), 9296−9331. DOI: 10.3390/ijms12129296.

1.1.

2011

Kuznetsov, A.V.; Margreiter, R.; Amberger, A.; Saks, V.; Grimm, M. (2011). Changes in mitochondrial dysfunction in doxorubicin-induced cell death. Biochimica et Biophysica Acta, 1813 (6), 1144−1152.10.1016/j.bbamcr.2011.03.002.

1.1.

2011

Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Kuznetsov, Andrey V.; Guzun, Rita; Saks, Valdur; Käämbre, Tuuli (2011). High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1807 (12), 1549−1561. DOI: 10.1016/j.bbabio.2011.08.005.

1.1.

2011

Guzun, R.; Timohhina, N.; Tepp, K.; Gonzalez-Granillo, M.; Shevchuk, I.; Chekulayev, V.; Kuznetsov, A.V.; Käämbre, T.; Saks, V.A. (2011). Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function. Amino Acids, 40, 1333−1348.

1.1.

2011

Guzun, Rita; Karu-Varikmaa, Minna; Gonzalez-Granillo, Marcela; Kuznetsov, Andrey V.; Michel, Lauriane; Cottet-Rousselle, Cecile; Saaremäe, Merle; Käämbre, Tuuli; Metsis, Madis; Grimm, Michael; Auffray, Charles; Saks, Valdur (2011). Mitochondria-cytoskeleton interaction: Distribution of beta-tubulins in cardiomyocytes and HL-1 cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1807 (4), 458−469. DOI: 10.1016/j.bbabio.2011.01.010.

5.1.

2011

Karu-Varikmaa, M.; Metsis, M.; Guzun, R.; Käämbre, T.; Grichine, A.; Saks, V. (2011). Investigation of interactions between mitochondrial creatine kinase and ATP/ADP channel. FEBS Journal, 278, 374−375.

5.1.

2011

Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux control with mitochondrial interactosome in cardiac cell. FEBS Journal, 278, 377−377.

5.1.

2011

Saks, V.; Aliev, M.; Tepp, K.; Karu-Varikmaa, M.; Chekulaev, V.; Shevchuk, I.; Käämbre, T.; Guzun, R. (2011). Quantitative Analysis of Integrated Energy Metabolism of Muscle Cells: Experimental and Theoretical Studies. Biophysical Journal, 100, 2a−2a.

5.2.

2011

Gonzalez-Granillo, M.A.; Karu-Varikmaa, M.; Saaremäe, M.; Michel, L.; Käämbre, T.; Saks, V.; Guzun, R. (2011). Mitochondrial Interactosome in Energy Metabolism in Healthy and Cancer Cells. Biophysical Journal, 100, 298a−298a.

5.2.

2011

Karu-Varikmaa, M.; Saaremäe, M.; Sikk, P.; Käämbre, T.; Metsis, M.; Saks, V. (2011). Regulation of Mitochondrial Respiration by Different Tubulin Isoforms in Vivo. Biophysical Journal, 100, 459a−459a.

1.1.

2010

Tepp, Kersti; Timohhina, Natalya; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes - experimental study. Acta Biochimica Polonica, 57 (4), 421−430.

1.1.

2010

Guzun, R.; Saks, V. (2010). Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo. International Journal of Molecular Sciences, 11, 982−1019. DOI: 10.3390/ijms11030982.

1.1.

2010

Tokarska-Schlattner, M.; Lucchinetti, E.; Zaugg, M.; Kay, L.; Gratia, S.; Guzun, R.; Saks, VA.; Schlattner, U. (2010). Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes. AJP Regulatory Integrative and Comparative Physiology, 298 (4), R1075−R1088.10.1152/ajpregu.00360.2009.

1.1.

2010

Saks, Valdur; Guzun, Rita; Timohhina, Natalja; Tepp, Kersti; Varikmaa, Minna; Monge, Claire; Beraud, Nathalie; Käämbre, Tuuli; Kuznetsov, Andrey; Kadaja, Lumme; Eimre, Margus; Seppet, Enn (2010). Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1797 (6-7), 678−697. DOI: 10.1016/j.bbabio.2010.01.011.

1.1.

2010

Guerrero, K.; Monge, C.; Brückner, A.; Puurand, U.; Kadaja, L.; Käämbre, T.; Seppet, E.; Saks, V. (2010). Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Molecular and Cellular Biochemistry, 337, 239−249. DOI: 10.1007/s11010-009-0304-1.

3.1.

2010

Monge, Claire; Guzun, Rita; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Sikk, Peeter; Käämbre, Tuuli; Saks, Valdur (2010). Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells. In: Oliver L. Svensson (Ed.). Mitochondria: Structure, Functions and Dysfunctions (441−470). . Nova Science Publisher Inc..

5.1.

2010

Varikmaa, Minna; Metsis, Madis; Guzun, Rita; Käämbre, Tuuli; Grichine, Alexei; Saks, Valdur (2010). Novel Method for Investigation of Interactions between Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase. Biophysical Journal, 98: Biophysical Society 54th Annual Meeting, February 20-24 , San Fransisco. 2010, 735a. (3).

5.1.

2010

Saks, V.; Guzun, R.; Timohhina, N.; Tepp, K.; Varikmaa, M.; Monge, C.; Beraud, N.; Kaambre, T.; Kuznetsov, A.; Kadaja, L.; Margus, E.; Seppet, E. (2010). Systems biology and bioenergetics: Structure-function relationships in feedback regulation of energy fluxes in vivo Mitochondrial interactosome. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−138. (Supplement 1). DOI: 10.1016/j.bbabio.2010.04.411.

5.1.

2010

Tepp, Kersti; Timohhina, Natalja; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−139. (Supplement 1). DOI: 10.1016/j.bbabio.2010.04.413.

1.1.

2009

Saks, V. (2009). Molecular System Bioenergetics-New Aspects of Metabolic Research. International Journal of Molecular Sciences, 10 (8), 3655−3657.

1.1.

2009

Kuznetsov, A.V.; Hermann, M.; Saks, V.; Hengster, P.; Margreiter, R. (2009). The cell-type specificity of mitochondrial dynamics. The International Journal of Biochemistry & Cell Biology, 41 (10), 1928−1939.

1.1.

2009

Beraud, Nathalie; Pelloux, Sophie; Usson, Yves; Kuznetsov, Andrey V.; Ronot, Xavier; Tourneur, Yves; Saks, Valdur (2009). Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells. Journal of Bioenergetics and Biomembranes, 41 (2), 195−214. DOI: 10.1007/s10863-009-9214-x.

1.1.

2009

Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.

1.1.

2009

Guzun, R.; Timohhina, N.; Tepp, K.; Monge, C.; Käämbre, T.; Sikk, P.; Kuznetsov, AV.; Pison, C.; Saks, V. (2009). Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ importance of system level properties. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1787 (9), 1089−1105. DOI: 10.1016/j.bbabio.2009.03.024.

1.1.

2009

Monge, Claire; Beraud, Nathalie; Tepp, Kersti; Pelloux, Sophie; Chahboun, Siham; Käämbre, Tuuli; Kadaja, Lumme; Roosimaa, Mart; Piirsoo, Andres; Tourneur, Yves; Kuznetsov, Andrey V; Saks, Valdur; Seppet, Enn (2009). Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Canadian Journal of Physiology and Pharmacology, 87 (4), 318−326.

1.1.

2009

Saks, Valdur; Monge, Claire; Guzun, Rita (2009). Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research. International Journal of Molecular Sciences, 10, 1161−1192.

1.1.

2009

Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu; Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.

5.2.

2009

Beraud, Nathalie; Pelloux, Sophie; Usson, Yves; Kuznetsov, Andrey V.; Ronot, Xavier; Tourneur, Yves; Saks, Valdur (2009). Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non-beating Hl-1 cells. Biophysical Journal, 96, 243a. DOI: 10.1016/j.bpj.2008.12.1197.

6.7.

2009

Saks, Valdur; Engelbrecht, Jüri; Seppet, Enn; Vendelin, Marko (2009). Molekulaarne süsteemne bioenergeetika : kommentaar Eesti Vabariigi teaduse aastapreemia pälvinud tööde tsüklile. Mägi, Vahur (Toim.). Tallinna Tehnikaülikooli aastaraamat 2008. XVI (291−298). . Tallinn: TTÜ kirjastus.

1.1.

2008

Rostovtseva, Tatiana K.; Sheldon, Kely L.; Hassanzadeh, Elnaz; Monge, Claire; Saks, Valdur; Bezrukov, Sergey M.; Sackett, Dan L. (2008). Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proceedings of the National Academy of Sciences of the United States of America, 105 (48), 18746−18751.

1.1.

2008

Kuznetsov, A.V.; Veksler, V.; Gellerich, F.N.; Saks, V.; Margreiter, R.; Kunz, W.S. (2008). Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nature Protocols, 3 (6), 965−976.

1.1.

2008

Saks, V. (2008). The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and alive. The Journal of Physiology, 586 (12), 2817−2818.

1.1.

2008

Monge, C.; Beraud, N.; Kuznetsov, A.V.; Rostovtseva, T.; Sackett, D.; Schlattner, U.; Vendelin, M.; Saks, V.A. (2008). Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion insitu, roles of tubulin, and mitochondrial creatine kinase. Molecular and Cellular Biochemistry, 318, 147−165. DOI: 10.1007/s11010-008-9865-7.

1.1.

2008

Saks, V.; Beraud, N.; Wallimann, T. (2008). Metabolic compartmentation - A system level property of muscle cells. International Journal of Molecular Sciences, 9 (5), 751−767.

1.1.

2008

Eimre, M.; Paju, K.; Pelloux, S.; Beraud, N.; Roosimaa, M.; Kadaja, L.; Gruno, M.; Peet, N.; Orlova, E.; Remmelkoor, R.; Piirsoo, A.; Saks, V.; Seppet, E. (2008). Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1777 (6), 514−524.

1.3.

2008

Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Tiivel, Toomas; Timohhina, Natalja; Nutt, Anu; Tepp, Kersti; Saks, Valdur (2008). Südamelihase rakkude struktuuri olulisusest rakuhingamise regulatsioonis. Eesti Arst, 1, 19−22.

5.1.

2008

Seppet, E.; Paju, K.; Roosimaa, M.; Kadaja, L.; Peet, N.; Eimre, M.; Orlova, E.; Saks, V. (2008). Distinct organization of energy metabolism in HL-1 cardiac cells and cardiomyocytes. Journal of Molecular and Cellular Cardiology, 44 (4), 780−781. DOI: 10.1016/j.yjmcc.2008.02.166.

5.2.

2008

Guzun, Rita; Timokhina, Nathalia; Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Saks, Valdur (2008). DIFFERENT STEADY STATE KINETICS OF REGULATION OF MtCK – DEPENDENT RESPIRATION IN ISOLATED MITOCHONDRIA AND PERMEABILIZED CARDIAC CELL in situ. Biophysical Society 52nd Annual Meeting & 16th International Biophysics Congress February 2-6, 2008 Long Beach, California.

5.2.

2008

Seppet, Enn; Saks, Valdur (2008). Structure-function relationships in organization of energy metabolism in cardiac cells. Experimental and Clinical Cardiology, 13: Mendel Symposium II: genes and the Heart, Joint Meeting of the japan and European sections of the International Academy of cardiovascular Sciences; Leblice, Czech Republic; September 24 to 27. _EditorsAbbr Ostadal, B. Canada: Pulsus Group Inc, 151−151.

5.2.

2008

Seppet, E.; Paju, K.; Roosimaa, M.; Kadaja, L.; Peet, N.; Eimre, M.; Orlova, E.; Saks, V. (2008). Distinct organization of energy metabolism in different types of cardiac cells. NATO Advanced Research Workshop on Translational Knowledge for Heart Research; Istanbul, Turkey; 12-16 May 2008.

6.7.

2008

[Saks, Valdur; Engelbrecht, Jüri; Seppet, Enn; Vendelin, Marko] (2008). Teaduspreemia geo-ja bioteaduste alal tööde tsükli "Molekulaarne süsteemne bioenergeetia" eest. Villems,Richard (Toim.). Eesti Vabariigi teaduspreemiad 2008 (110−123). . Tallinn: Eesti Teaduste Akadeemia.

3.1.

2007

Saks, V. (2007). From the discovery of oxygen to molecular system bioenergetics. In: V.Saks (_EditorsAbbr). MOLECULAR SYSTEM BIOENERGETICS./ ENERGY FOR LIFE (x).. Manheim: Wiley-VCH.

3.1.

2007

Saks, Valdur; Dzeja, Petras P.; Guzun, Rita; Aliev, Mayis K.; Vendelin, Marko; Terzic, André; Wallimann, Theo (2007). System analysis of cardiac energetics - excitation-contraction coupling: integration of mitochondrial respiration, phosphotransfer pathways, metabolic pacing and substrate supply in the heart. In: Saks, Valdur (Ed.). Molecular system bioenergetics: energy for life (367−406). . Weinheim: Wiley-VCH. DOI: 10.1002/9783527621095.ch11.

3.1.

2007

Saks, V.; Monge, C.; Anmann, T.; Dzeja, P. (2007). Integrated and organized cellular energetic systems: theories of cell energetics, compartmentation and metabolic channeling. In: V.Saks (Ed.). MOLECULAR SYSTEM BIOENERGETICS./ ENERGY FOR LIFE (59−97). . Manheim: Wiley-VCH.

3.1.

2007

Saks, V.; Kaambre, T.; Guzun, R.; Anmann, T.; Sikk, P.; Schlattner, U.; Wallimann, T.; Aliev, M.; Vendelin, M. (2007). The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches. In: Salomons, G.S.; Wyss, M. (Ed.). Creatine and Creatine Kinase in Health and Disease (27−65). . Dordrecht: Springer. (Subcellular Biochemistry; 46). DOI: 10.1007/978-1-4020-6486-9_3.

3.1.

2007

Vendelin, Marko; Saks, Valdur; Engelbrecht, Jüri (2007). Principles of mathematical modeling and in silico studies of integrated cellular energetics. In: Saks,Valdur (Ed.). Molecular system bioenergetics: energy for life (407−433). . Weinheim: Wiley-VCH. DOI: 10.1002/9783527621095.ch12.

3.1.

2007

Saks, V.A.; Vendelin, M.; Aliev, M.K.; Kekelidze, T.; Engelbrecht, J. (2007). Mechanisms and modeling of energy transfer between intracellular compartments. In: Lajtha, A.; Gibson, G. E.; Dienel, G. A. (Ed.). Handbook of Neurochemistry and Molecular Neurobiology : Brain Energetics. Integration of Molecular and Cellular Processes (815−860). . New York: Springer. (8.1). DOI: 10.1007/978-0-387-30411-3_30.

4.1.

2007

Saks, Valdur (Editor) (2007). Molecular System Bioenergetics: Energy for Life. Manheim: Wiley-VCH.

5.1.

2007

Saks, V.A.; Vendelin, M.; Aliev, M.; Monge, C.; Engelbrecht, J. (2007). Molecular system bioenergetics: Mechanisms and modelling of energy transfer between intracellular compartments. Journal of Neurochemistry, 102, 16.

5.1.

2007

Vendelin, M.; Anmann, T.; Kaambre, T.; Sikk, P.; Saks, V. (2007). Modeling of the coupled enzyme systems: model of mitochondrial creatine kinase (miCK) and adenine nucleotide translocase (ANT) coupling. Biophysical Journal, Suppl S, 660A.

5.1.

2007

Anmann, T., Monge, C., Bemud, N., Pelloux, S., Toumeur, Y., Saks, V. (2007). Coupled creatine kinase systems in cardiac cells and synaptosomes: a comparative kinetic study. Biophysical Society Meeting Abstracts: 51st Annual Meeting of the Biophysical-Society, Baltimore, MD, MAR 03-07, 2007. BioPhysical Society, 621A. (Biophysical Journal Supplement).

1.1.

2006

Anmann, T.; Guzun, R.; Beraud, N.; Pelloux, S.; Kuznetsov, A.V.; Kogerman, L.; Kaambre, T.; Sikk, P.; Paju, K.; Peet, N.; Seppet, E.; Ojeda, C.; Tourneur, Y.; Saks, V. (2006). Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells - Importance of cell structure/organization for respiration regulation. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1757 (12), 1597−1606 . DOI: 10.1016/j.bbabio.2006.09.008.

1.1.

2006

Saks, Valdur; Dzeja, Petras; Schlattner, Uwe; Vendelin, Marko; Terzic, Andre; Wallimann, Theo (2006). Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. The Journal of Physiology, 571 (2), 253−273. DOI: 10.1113/jphysiol.2005.101444.

1.1.

2006

Eimre, M.; Puhke, R.; Alev, K.; Seppet, E.; Sikkut, A.; Peet, N.; Kadaja, L.; Lenzner, A.; Haviko, T.; Seene, T.; Saks, V.A.; Seppet, E.K. (2006). Altered mitochondrial apparent affinity for ADP and impaired function of mitochondrial creatine kinase in gluteus medius of patients with hip osteoarthritis. AJP Regulatory Integrative and Comparative Physiology, 290 (5), R1271−R1275.

1.1.

2006

Pelloux, S.; Robillard, J.; Ferrera, R.; Bilbaut, A.; Ojeda, C.; Saks, V.; Ovize, M.; Tourneur, Y. (2006). Non beating HL-1 cells for confocal microscopy. Application to mitochondrial functions during cardiac preconditioning. Progress in Biophysics and Molecular Biology, 90, 270−298.

1.2.

2006

Seppet, E.K.; Eimre, M.; Anmann, T.; Seppet, E.; Piirsoo, A.; Peet, N.; Paju, K.; Guzun, R.; Beraud, N.; Pelloux, S.; Tourneur, Y.; Kuznetsov, A.V.; Käämbre, T.; Sikk, P.; Saks, V.A. (2006). Structure-function relationships in regulation of the energy transfer between mitochondria and ATPases in cardiac cells. Experimental and Clinical Cardiology, 11 (3), 189−194.

3.1.

2006

Saks, V.; Guerrero, K.; Vendelin, M.; Engelbrecht, J.; Seppet, E. (2006). The creatine kinase isoenzymes in organized metabolic networks and regulation of cellular respiration: a new role for Maxwell's demon. In: Vial, C. (Ed.). Creatine Kinase (223−267). . New York: Nova Science Publishers. (Molecular Anatomy and Physiology of Proteins).

3.2.

2006

Saks, V.; Aliev, M.; Guzun, R.; Beraud, N.; Monge, C.; Anmann, T.; Kuznetsov, A.; Seppet, E. (2006). Biophysics of the organized metabolic networks in muscle and brain cells. In: Pandalai, S.G. (Ed.). Recent Research Developments in Biophysics (269−318). . Kerala, India: Transworld Research Networks.

5.1.

2006

Seppet, E.K.; Eimre, M.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Kaambre, T.; Saks, VA. (2006). Calcium-induced contraction of sarcomeres changes the interaction between mitochondria and ATPases in permeabilized cardiac cells. Journal of Molecular and Cellular Cardiology, 40 (6), 931−931.

5.1.

2006

Beraud, N.; Pelloux, S.; Kuznetsov, A.; Guzun, R.; Anmann, T.; Tourneur, Y.; Ojeda, C.; Saks, V. (2006). Comparative bioeneregetics of isolated cardiomyocytes and HL-1 cells: Mitochondrial dynamics, respiration regulation and creatine kinase expression. , 514−515.

5.2.

2006

Eimre, M.; Seppet, E.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Käämbre, T.; Saks, V. (2006). Kaltsiumist põhjustatud sarkomeeride kontraktsioon muudab mitokondrite ja ATPaaside vahelist interaktsiooni permeabiliseeritud südamerakkudes. 85. , 645−646.

1.1.

2005

Guerrero, Karen; Wuyam, Bernard; Mezin, Paulette; Vivodtzev, Isabelle; Vendelin, Marko; Borel, Jean Christian; Hacini, Rachid; Chavanon, Olivier; Imbeaud, Sandrine; Saks, Valdur; Pison, Christophe (2005). Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle. AJP Regulatory Integrative and Comparative Physiology, 289 (4), R1144−R1154.

1.1.

2005

Vendelin, Marko; Beraud, Nathalie; Guerrero, Karen; Andrienko, Tatiana; Kuznetsov, Andrey V.; Olivares, Jose; Kay, Laurence; Saks, Valdur A. (2005). Mitochondrial regular arrangement in muscle cells: a "crystal-like" pattern. American Journal of Physiology - Cell Physiology, 288 (3), C757−C767.

1.1.

2005

Saks, V.A.; Wallimann, T.; Schlattner, U. (2005). Calcium and energy transfer. The Journal of Physiology, 565 (2), 703−703.

1.1.

2005

Peltier, S.; Burelle, Y.; Novel-Chate, V.; Demaison, L.; Verdys, M.; Saks, V.; Keriel, C.; Leverve, XM. (2005). Effect of exogenous adenosine and monensin on glycolytic flux in isolated perfused normoxic rat hearts: Role of pyruvate kinase. Molecular and Cellular Biochemistry, 277, 55−61.

1.1.

2005

Anmann, T.; Eimre, M.; Kuznetsov, AV.; Andrienko, T.; Kaambre, T.; Sikk, P.; Seppet, E.; Tiivel, T.; Vendelin, M.; Seppet, E.; Saks, VA. (2005). Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal, 272 (12), 3145−3161. DOI: 10.1111/j.1742-4658.2005.04734.x.

1.1.

2005

Seppet, E.; Eimre, M.; Peet, N.; Paju, K.; Orlova, E.; Ress, M.; Kovask, S.; Piirsoo, A.; Saks, VA.; Gellerich, FN.; Zierz, S.; Seppet, EK. (2005). Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Molecular and Cellular Biochemistry, 270, 49−61.

1.1.

2005

Seppet, E. K.; Eimre, M.; Anmann, T.; Seppet, E.; Peet, N.; Käämbre, T.; Paju, K.; Piirsoo, A.; Kuznetsov, A. V.; Vendelin, M.; Gellerich, F. N.; Zierz, S.; Saks, V. A. (2005). Intracellular energetic units in healthy and diseased hearts. Experimental and Clinical Cardiology, 10 (3), 173−183.

5.1.

2005

Kuznetsov, AV.; Kaambre, T.; Sikk, P.; Saks, V. (2005). Ca2+ and regulation of mitochondrial respiration: Functional and confocal imaging studies. 23, Suppl 2. , 8−8.

1.1.

2004

Saks, V.; Kuznetsov, A.V.; Vendelin, M.; Guerrero, K.; Kay, L.; Seppet, E.K. (2004). Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism. Molecular and Cellular Biochemistry, 256/257, 185−199. DOI: 10.1023/B:MCBI.0000009868.92189.fb.

1.1.

2004

Vendelin, Marko; Eimre, Margus; Seppet, Evelin; Peet, Nadezda; Andrienko, Tatiana; Lemba, Maris; Engelbrecht, Jüri; Seppet, Enn K.; Saks, Valdur A. (2004). Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscle. Molecular and Cellular Biochemistry, 256, 229−241. DOI: 10.1023/B:MCBI.0000009871.04141.64.

1.1.

2004

Vendelin, Marko; Lemba, Maris; Saks, Valdur A. (2004). Analysis of functional coupling: Mitochondrial creatine kinase and adenine nucleotide translocase. Biophysical Journal, 87 (1), 696−713.

1.1.

2004

Ovadi, J.; Saks, V. (2004). On the origin of intracellular compartmentation and organized metabolic systems. Molecular and Cellular Biochemistry, 5−12.

1.1.

2004

Ojeda, C.; Joseph, P.; Saks, V. A.; Piriou, V.; Tourneur, Y. (2004). Subcellular heterogeneity in mitochondrial red-ox responses to KATP channel agonists in freshly isolated rabbit cardiomyocytes. Molecular and Cellular Biochemistry, 367−377.

1.1.

2004

Kuznetsov, A. V.; Schneeberger, S.; Seiler, R.; Brandacher, G.; Mark, W.; Steurer, W.; Saks, V.; Usson, Y.; Margreiter, R.; Gnaiger, E. (2004). Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. AJP Heart and Circulatory Physiology, 286 (5), H1633−H1641.

1.1.

2004

Kuznetsov, A. V.; Schneeberger, S.; Renz, O.; Meusburger, H.; Saks, V.; Usson, Y.; Margreiter, R. (2004). Functional heterogeneity of mitochondria after cardiac cold ischemia and reperfusion revealed by confocal imaging. Transplantation, 77, 754−756.

1.1.

2004

Kulp, M.; Kaljurand, M.; Kaambre, T.; Sikk, P.; Saks, V (2004). In situ monitoring of kinetics of metabolic conversion of ATP to ADP catalyzed by mgatpases of muscle Gastrocnemius skinned fibers using micellar electrokinetic chromatography. Electrophoresis, 25 (17), 2996−3002.

1.1.

2004

Seppet, EK.; Eimre, M.; Andrienko, T.; Kaambre, T.; Sikk, P.; Kuznetsov, AV.; Saks, V. (2004). Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modelling. Molecular and Cellular Biochemistry, 256, 219−227.

5.1.

2004

Vendelin, Marko; Lemba, Maris; Saks, Valdur A. (2004). Analysis of functional coupling: Mitochondrial creatine kinase and adenine nucleotide translocase. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1658, 198.

5.1.

2004

Vendelin, M.; Guerrero, K.; Andrienko, T.; Saks, V. (2004). Intracellular restrictions of diffusion and metabolic channeling of ADP in cardiac muscle cells. Biophysical Journal, 86 (1), 336A, Part 2 Suppl. S, JAN 2004.

5.1.

2004

Saks, V.; Andrienko, T.; Kuznetsov, A.; Zorov, D; Käämbre, T.; Sikk, P. (2004). Ca2+ contraction and mitochondria in heart: A mechanochemical link? 86. , 336A−337A.

5.1.

2004

Seppet, E.; Eimre, M.; Peet, N.; Paju, K.; Ress, M.; Kovask, S.; Saks, VA.; Gellerich, FN.; Zierz, S.; Seppet, EK. (2004). Intracellular energetic units in diseased human atrial myocardium. Journal of Molecular and Cellular Cardiology, 36 (5), 758−758.

1.1.

2003

Aliev, MK.; Saks, VA. (2003). Analysis of the mechanism of functioning of mitochondrial adenine nucleotide translocase using mathematical models. Biofizika, 48 (6), 1075−1085.

1.1.

2003

Vendelin, M.; Bovendeerd, P.H.M.; Saks, V.; Engelbrecht, J.; Arts, T. (2003). Simulating cardiac mechanoenergetics in the left ventricle. Functional Imaging and Modeling of The Heart, Proceedings. , 72−80. (Lecture Notes in Computer Science).

1.1.

2003

Andrienko, T.; Kuznetsov, A.V.;Kaambre, T.; Usson, Y.; Orosco, A.; Appaix, F.; Tiivel, T.; Sikk, P.; Vendelin, M.; Margreiter, R.; Saks, V.A. (2003). Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. Journal of Experimental Biology, 206 (12), 2059−2072.

1.1.

2003

Saks, Valdur; Kuznetsov, Andrey; Andrienko, Tatiana; Usson, Yves; Appaix, Florence; Guerrero, Karen; Kaambre, Tuuli; Sikk, Peeter; Lemba, Maris; Vendelin, Marko (2003). Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophysical Journal, 84 (5), 3436−3456. DOI: 10.1016/S0006-3495(03)70065-4.

1.1.

2003

Kuznetsov, A.V.; Kunz, W. S.; Saks, V.; Usson, Y.; Mazat, J. P.; Letellier, T.; Gellerich, F. N.; Margreiter, R. (2003). Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibers. Analytical Biochemistry, 319 (2), 296−303.

1.1.

2003

Appaix, F.; Kuznetsov, A. V.; Usson, Y.; Kay, L.; Andrienko, T.; Olivares, J.; Kaambre, T.; Sikk, P.; Margreiter, R.; Saks, V. (2003). Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Experimental Physiology, 88, 175−190. DOI: 10.1113/eph8802511.

3.1.

2003

Seppet, E.; Peet, N.; Paju, K.; Ress, M.; Saks, V.; Gellerich, FN; Chen, Y.; Trumbeckaite, S.; Prondzinsky, R; Silber, R.; Werdan, K; Zierz, S.; Seppet, E. (2003). Mitochondrial function in failing human myocardium in vivo: atrioventricular differences. In: Singal P.K.; Dixon, I.M.C.; Kirshenbaum, L.A.; Dhalla, N.S. (Ed.). Cardiac Remodeling and Failure (459−470). . Dodrecht: Kluwer Academic Publishers. (Progress in Experimental Cardiology; 5).

3.1.

2003

Saks, V.A.; Kay, L.; Appaix, F.; Andrienko, T.; Seppet, E. (2003). Creatine kinase and brain energy metabolism: Function and disease. In: Kekelidze, T.; Holtzman, D. (_EditorsAbbr). Creatine Kinase and Brain Energy Metabolism (3−25).. Amsterdam, The Netherlands: IOS Press. (NATO Science Series: Life and Behavioural Sciences; 342).

3.1.

2003

Saks, V.; Appaix, F.; Usson, Y.; Guerrero, K.; Olivares, J.; Seppet, E.; Aliev, M.; Margreiter, R.; Kuznetsov, A. (2003). Localized control of oxidative phosphorylation within intracellular energetic units in heart cells: A possible solution of some old problems. In: Dhalla, N.S.; Hryshko, L.; Kardami, E. (_EditorsAbbr). Signal Transduction and Cardiac Hypertrophy (265−284).. Boston, USA: Kluwer Academic Publishers.

1.1.

2002

Vendelin, M.; Bovendeerd, P.; Saks, V.; Engelbrecht, J. (2002). Cardiac mechanoenergetics in silico. Neuroendocrinology Letters, 23 (1), 13−20.

1.1.

2002

Boudina, S.; Laclau, M. N.; Tariosse, L.; Daret, D.; Gouverneur, G.; Bonoron-Adele, S.; Saks, V. A.; DosSantos, P. (2002). Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. AJP Heart and Circulatory Physiology, 282 (3), H821−H831.

1.1.

2002

Aliev, M.K.; DosSantos, P.; Hoerter, J.A.; Soboll, S.; Tikhonov, A.N.; Saks, V.A. (2002). Water content and its intracellular distribution in intact and saline perfused rat hearts revisited. Cardiovascular Research, 53 (1), 48−58.

1.1.

2002

Appaix, F.; Guerrero, K.; Rampal, D.; Izikki, M.; Kaambre, T.; Sikk, P.; Brdiczka, D.; Riva-Lavieille, C.; Olivares, J.; Longuet, M.; Antonsson, B.; Saks, V. (2002). Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochimica et Biophysica Acta, 1556, 156−167.

5.1.

2002

Saks, V.; Kay, L.; Andrienko, T.; Vendelin, M. (2002). Local restrictions of ADP diffusion between intracellular energetic units in cardiomyocytes. Biophysical Journal, 82 (1), 2991.

1.1.

2001

Walsh, B.; Tonkonogi, M.; Soderlund, K.; Hultman, E.; Saks, V.; Sahlin, K. (2001). The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. The Journal of Physiology, 537 (3), 971−978.

1.1.

2001

Riva, C.; Chevrier, C.; Pasqual, N.; Saks, V.; Rossi, A. (2001). Bcl-2/Bax protein expression in heart, slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions. Molecular and Cellular Biochemistry, 226, 9−16.

1.1.

2001

Laclau, M. N.; Boudina, S.; Thambo, J. B.; Tariosse, L.; Gouverneur, G.; Bonoron-Adele, S.; Saks, V.A.; Garlid, K. D.; DosSantos, P. (2001). Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. Journal of Molecular and Cellular Cardiology, 33 (5), 947−956.

1.1.

2001

Menin, L.; Panchichkina, M.; Keriel, C.; Olivares, J.; Braun, U.; Seppert, EK.; Saks, VA. (2001). Macrocompartmentation of total creatine in cardiomyocytes revisited. Molecular and Cellular Biochemistry, 220, 149−159.

1.1.

2001

Seppet, EK.; Kaambre, T.; Sikk, P.; Tiivel, T.; Vija, H.; Tonkonogi, M.; Sahlin, K.; Kay, L.; Appaix, F.; Braun, U.; Eimre, M.; Saks, VA. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1504, 379−395. DOI: 10.1016/S0005-2728(00)00269-3.

1.1.

2001

Saks, VA.; Kaambre, T.; Sikk, P.; Eimre, M.; Orlova, E.; Paju, K.; Piirsoo, A.; Appaix, F.; Kay, L.; Regitz-Zagrosek, V.; Fleck, E.; Seppet, E. (2001). Intracellular energetic units in red muscle cells. Biochemical Journal, 356, 643−657.

5.1.

2001

Saks, V.; Kay, L.; Sikk, P.; Kaambre, T.; Seppet, E.; Piirsoo, A. (2001). Intracellular energetic units in muscle cells? Biophysical Journal, 80 (1), 583A−583A.

1.1.

2000

Saks, V.A.; Kongas, O.; Vendelin, M.; Kay, L. (2000). Role of the creatine/phosphocreatine system in the regulation of mitochondrial respiration. Acta Physiologica Scandinavica, 168 (4), 635−641. DOI: 10.1046/j.1365-201x.2000.00715.x.

1.1.

2000

Vendelin, M.; Kongas, O.; Saks, V. (2000). Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer. American Journal of Physiology - Cell Physiology, 278 (4), C747−C764.

1.1.

2000

Kay, L.; Nicolay, K.; Wieringa, B.; Saks, V.; Wallimann, T. (2000). Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ. Journal of Biological Chemistry, 275 (10), 6937−6944.

1.1.

2000

DosSantos, P.; Aliev, M. K.; Diolez, P.; Duclos, F.; Besse, P.; Bonoron-Adele, S.; Sikk, P.; Canioni, P.; Saks, V.A. (2000). Metabolic control of contractile performance in isolated perfused rat heart. Analysis of experimental data by reaction:diffusion mathematical model. Journal of Molecular and Cellular Cardiology, 32, 1703−1734.

1.1.

2000

Tiivel, T.; Kadaya, L.; Kuznetsov, A.; Kaambre, T.; Peet, N.; Sikk, P.; Braun, U.; Ventura-Clapier, R.; Saks, V.; Seppet, EK. (2000). Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry, 208, 119−128.

3.1.

2000

Saks, V.; Vendelin, M.; Kongas, O.; Kay, L. (2000). Creatine-phosphocreatine pathway in the intracellular networks of energy transfer and signal transduction in muscle cells. Creatine: from basic science to clinical application, 0928-9550. Ed. Paoletti, R.; Poli, A.; Jackson, A.S. Dordrecht: Kluwer Academic Publishers, 1−9. (Medical science symposia series; 14).

5.1.

2000

Saks, VA.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Tonkonogi, M.; Seppet, E.; Sahlin, K. (2000). Metabolic channelling in cardiac cells: Dependence of kinetics of respiration regulation on source of ADP. Biophysical Journal, 78 (1), 197A−197A.

5.1.

2000

Kongas, O.; Vendelin, M.; Saks, V. (2000). In silico regulation of oxidative phosphorylation in muscle cells in health and disease. Biophysical Journal, 78 (1), 1159Pos.

1.1.

1999

Tonkonogi, M.; Walsh, B.; Tiivel, T.; Saks, V.; Sahlin, K. (1999). Mitochondrial function in human skeletal muscle is not impaired by high intensity exercise. Pflugers Archiv-European Journal of Physiology, 437 (4), 562−568.

1.2.

1999

Kongas, O.; Vendelin, M.; Saks, V. (1999). Modeling of intracellular compartmentalized energy and metabolic fluxes in the heart. Medical & Biological Engineering & Computing, 37, 27−32.

5.1.

1999

Saks, V.A.; Aliev, M.; Kongas, O.; Vendelin, M. (1999). The regulation of mitochondrial activity in muscle cells by cytosolic factors: Experimental and theoretical analyses. Biophysical Journal, 76 (1), A2, Part 2.

5.2.

1999

Kadaja, Lumme; Peet, Nadežda; Braun, U; Vibo, Riina; Metsküla, Kaja; Tiivel, Toomas; Käämbre, Tuuli; Sikk, P; Kuznetsov, A; Ventura-Clapier, R; Saks, Valdur; Seppet, Evelin (1999). Oksüdatiivse fosforüülimise postnataalne regulatsioon roti müokardis in situ. Arstiteaduskonna aastakonverents, 7. oktoober 1999 : teesid, 35−36.

1.1.

1998

Saks, V.A.; Veksler, V.I.; Kuznetsov, A.V.; Kay, L.; Sikk, P.; Tiivel, T.; Tranqui, L.; Olivares, J.; Winkler, K.; Wiedemann, F.; Kunz, W.S. (1998). Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo. Molecular and Cellular Biochemistry, 184, 81−100.

1.1.

1998

Saks, V.; Aliev, M.; DosSantos, P.; Vendelin, M.; Kongas, O. (1998). Mathematical model of energy transfer in hearts with inhibited or ablated creatine kinase system. Magnetic Resonance Materials in Physics, Biology and Medicine, 6, 124−125. DOI: 10.1016/S1352-8661(98)00037-4.

1.1.

1998

Voloschuk, S.G.; Belikova, Yu.O.; Klushnik, T.P.; Benivalensky, D.S.; Saks, V.A. (1998). Comparative study of the kinetics of respiration and protein content of skinned fibers from different muscle types. Biokhimiya, 63 (2), 190−193.

1.1.

1998

Saks, V.A..; VenturaClapier, R.; Leverve, X.; Rossi, A.; Rigoulet, M. (1998). What do we not know of cellular bioenergetics? – a general view on the state of the art. Molecular and Cellular Biochemistry, 184, 3−9.

1.1.

1998

Saks, V.A.; DosSantos, P.; Gellerich, F.N.; Diolez, P. (1998). Quantitative studies of enzyme - substrate compartmentation, functional coupling and metabolic channelling in muscle cells. Molecular and Cellular Biochemistry, 184, 291−307.

1.1.

1998

Aliev, M.K.; vanDorsten, F.A.; Nederhoff, M.G.; vanEchteld, C.J.A.; Veksler, V.; Nicolay, K.; Saks, V.A. (1998). Mathematical model of compartmentalized energy transfer: its use for analysis and interpretation of 31P - NMR studies of isolated heart of creatine kinase deficient mice. Molecular and Cellular Biochemistry, 184, 209−229.

1.1.

1998

Rossi, A.; Kay, L.; Saks, V.A. (1998). Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: a potential cause for altered energy transfer in cardiac muscle? Molecular and Cellular Biochemistry, 184, 401−408.

1.1.

1998

Khuchua, Z.AL.; Qin, W.; Boero, J.; Cheng, J.; Payne, M.; Saks, V.A.; Strauss, A.W. (1998). Octamer formation by cardiac sarcomeric mitochondrial creatine kinase is mediated by charged N – terminal residues. Journal of Biological Chemistry, 273 (36), 22990−22996.

1.1.

1998

Novel-Chaté, V.; Mateo, P.; Saks, V.A.; Hoerter, J.A.; Rossi, A. (1998). Chronic exposure to hypoxic environment alters the mechanism of energy transfer in myocardium. Journal of Molecular and Cellular Cardiology, 30 (7), 1295−1303.

1.2.

1998

Seppet, E. K.; Kadaya, L.; Peet, N.; Käämbre, T.; Sikk, P.; Saks, V. A. (1998). The 27.5 kD protein appears to control the oxidative phosphorylation in slow twitch muscle cells. Pathophysiology, 5, 121−121.

1.1.

1997

Anflous, K.; Saks, V.; Mateo, P.; Samson, F.; Veksler, V.; Ventura-Clapier, R. (1997). Mitochondrial creatine kinase isoform expression does not correlate with its mode of action. Biochemical Journal, 322, 73−78.

1.1.

1997

Aliev, M.K.; Saks, V.A. (1997). Compartmentalised energy transfer in cardiomyocytes. Use of mathematical modelling for analysis of in vivo regulation of respiration. Biophysical Journal, 73 (1), 428−445.

1.1.

1997

Kay, L.; Daneshrad, Z.; Saks, V.A.; Rossi, A. (1997). Alteration in the control of mitochondrial respiration by outer mitochondrial membrane and creatine during heart preservation. Cardiovascular Research, 34 (3), 547−556.

1.1.

1997

Kay, L.; Saks, V.A.; Rossi, A. (1997). Early alteration of the control of mitochondrial function in myocardial ischemia. Journal of Molecular and Cellular Cardiology, 29 (12), 3399−3411.

1.1.

1997

Kay, L.; Li, ZL.; Mericskay, M.; Olivares, J.; Tranqui, L.; Fontaine, E.; Tiivel, T.; Sikk, P.; Kaambre, T.; Samuel, JL.; Rappaport, L.; Usson, Y.; Leverve, X.; Paulin, D.; Saks, VA. (1997). Study of regulation of mitochondrial respiration in vivo An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1322 (1), 41−59. DOI: 10.1016/S0005-2728(97)00071-6.

1.1.

1996

Pelouch, V.; Kolar, F.; Khuchua, Z.; Elizarova, G.; Milerova, M.; Oštadal, B.; Saks, V. (1996). Cardiac phosphocreatine deficiency induced by GPA during postnatal development in rat. Molecular and Cellular Biochemistry, 164, 67−76.

1.1.

1996

Saks, V.A.; Ventura-Clapier, R.; Aliev, M. (1996). Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells. Biochimica et Biophysica Acta, 1274 (3), 81−88.

1.1.

1996

Saks, V.A.; Aliev, M.K. (1996). Is there the creatine kinase equilibrium in working heart cells? Biochemical and Biophysical Research Communications, 227 (2), 360−367.

1.1.

1996

Nascimben, L.; Ingwall, J.; Pauletto, P.; Friedrich, J.; Gwathmey, J.K.; Saks, V.A.; Pessina, A.C.; Allen, P.D. (1996). Creatine kinase system in failing and nonfailing human myocardium. Circulation, 94 (8), 1894−1901.

1.1.

1996

Saks, VA.; Tiivel, T.; Kay, L.; NovelChate, V.; Daneshrad, Z.; Rossi, A.; Fontaine, E.; Keriel, C.; Leverve, X.; VenturaClapier, R.; Anflous, K.; Samuel, JL.; Rappaport, L. (1996). On the regulation of cellular energetics in health and disease. Molecular and Cellular Biochemistry, 161, 195−208.

1.1.

1996

Kuznetsov, AV.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Daneshrad, Z.; Rossi, A.; Kadaja, L.; Peet, N.; Seppet, E.; Saks, VA. (1996). Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. European Journal of Biochemistry, 241 (3), 909−915.

1.1.

1996

Bichevin, V.; Kaambre, H.; Sammelselg, V.; Kelle, H.; Asari, E.; Saks, O. (1996). Exoemissive noise activity of different metallic materials. Review of Scientific Instruments, 67 (11), 3951−3953.

1.3.

1996

Martin, Ivar; Männik, Erik; Lille, Ülo; Lakomkin, Vladimir; Steinschneider, Aleksandr; Kuznetsov, Andrei; Ljapina, Svetlana; Saks, Valdur (1996). The effect of the trimer of 16,16-dimethyl-15-keto-PGB1 on metabolic and functional post-ischemic recovery of the heart. Proceedings of the Estonian Academy of Sciences. Biology, 3/4, 93−101.

3.1.

1996

Saks, V.A.; Stepanov, V.A.; Jaliashvili, I.V.; Konorev, E.A.; Kryzanovsky, S.; Ettore, Strumia (1996). Molecular and cellular mechanisms of action for the cardioprotective and therapeutic role of creatine phosphate. M. Conway, J.F.Clark. Creatine and Creatine phosphate: scientific and clinical perspectives (91−114). . San Diego- London - New York: Academic Press.

1.1.

1995

Saks, V.; Belikova, Y.; Vasilyeva, E.; Kuznetsov, A.; Fontaine, E.; Keriel, C.; Leverve, X. (1995). Correlation between degree of rupture of outer mitochondrial membrane and changes of kinetics of regulation of respiration by ADP in permeabilized heart and liver cells. Biochemical and Biophysical Research Communications, 208 (3), 919−926.

1.1.

1995

Novel-Chate, V.; Aussedat, J.; Saks, V.A.; Rossi, A. (1995). Adaptation to chronic hypoxia alters cardiac metabolic response to  stimulation: novel face of phosphocreatine overshoot phenomenon. Journal of Molecular and Cellular Cardiology, 27 (8), 1679−1687.

1.1.

1995

Fontaine, E.M.; Keriel, C.; Lantuejoul, S.; Rigoulet, M.; Leverve, X.M.; Saks, V. (1995). Cytoplasmic cellular structures control permeability of outer mitochondrial membrane for ADP and oxidative phosphorylation in rat liver cells. Biochemical and Biophysical Research Communications, 213 (1), 138−146.

1.1.

1995

Saks, VA.; Kuznetsov, AV.; Khuchua, ZA.; Vasilyeva, EV.; Belikova, JO.; Kesvatera, T.; Tiivel, T. (1995). Control of cellular respiration in-vivo by mitochondrial outer-membrane and by creatine-kinase - a new speculative hypothesis - possible involvement of mitochondrial-cytoskeleton interactions. Journal of Molecular and Cellular Cardiology, 27 (1), 625−645.

3.4.

1995

Saks, V.A.; Kay, L.; Rossi, A.; Toompuu, M.; Utno, L.; Rätsep, I.; Sulling, T. (1995). A novel method for evaluation of efficiency of heart preservation and intraoperational protection by analysis of the respiration of skinned cardiac fibers. Heart Surgery 1995: 6th International Symposium on Cardiac Surgery. Rome (Italy), May 29-June 1st. Rome (Italy), 197−212.

1.1.

1994

Clark, J. F.; Khuchua, Z.; Kuznetsov, A.V.; Vassileva, E.; Boehm, E.; Radda, G. K.; Saks, V. A. (1994). Actions of the creatine analogue beta-guanidinopropionic acid on rat heart mitochondria. Biochemical Journal, 300, 211−216.

1.1.

1994

Saks, V. A.; Khuchua, Z. A.; Vasilyeva, E. V.; Belikova, Y. O.; Kuznetsov, A. (1994). Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration. A Synthesis. Molecular and Cellular Biochemistry, 133, 155−192.

1.1.

1994

Clark, J.F.; Kuznetsov, A.V.; Khuchua, Z.; Veksler, V.; Ventura-Clapier, R.; Saks, V. (1994). Creatine kinase function in mitochondria isolated from gravid and non-gravid guinea - pig uteri. FEBS Letters, 347, 147−151.

1.1.

1994

Saks, V. A.; Khuchua, Z. A.; Vasilyeva, E. V.; Belikova, Y. O.; Kuznetsov, A. (1994). Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration. A Synthesis. Saks V. A., Ventura-Clapier R.. Cellular Bioenergetics. Role of coupled creatine kinase (155−192). . Dordrecht-Boston-London: Kluwer Academic Publishers.

1.1.

1994

Aliev, M. K.; Saks, V. A. (1994). Mathematical modelling of intracellular transport processes and the creatine kinase systems: a probability approach. Saks V. A., Ventura-Clapier R.. Cellular Bioenergetics. Role of coupled creatine kinase (333−346). . Dordrecht-Boston-London: Kluwer Academic Publishers.

1.1.

1994

Panchenko, E.; Dobrovolsky, A.; Rogoza, A.; Sorokin, E.; Ageeva, N.; Markova, L.; Titaeva, E.; Anuchin, V.; Karpov, Y.; Saks, V. (1994). The effect of exogenous phosphocreatine on maximal walking distance, blood rheology, platelet aggregation, and fibrinolysis in patients with intermittent claudication. International Angiology, 13 (1), 59−64.

1.1.

1994

Seppet, EK.; Saks, VA. (1994). Thyroid-hormones and the creatine-kinase system in cardiac-cells. Molecular and Cellular Biochemistry, 133, 299−309.

2.1.

1994

Saks, V. A.; Ventura-Clapier, R. (toim.) (1994). Cellular Bioenergetics. Role ocoupled creatine kinase. Dordrecht-Boston: Kluwer Academic Publishers.

3.2.

1994

Kapelko, V. I.; Popovich, M. I.; Veksler, V. I.; Ventura-Clapier, R.; Khuchua, Z.A.; Saks, V. A. (1994). Subcellular basis for increased diastolic stiffness in experimental cardiomyopathies. Nagano M., Takeda N., Dhalla N. S.. The Cardiomyopathic Heart (185−195). . New York: Raven Press.

3.2.

1994

Saks, V. A.; Vasilyeva, E. V.; Khuchua, Z. A.; Belikova, Y. O.; Aliev, M. K.; Kesvatera, T.; Tiivel, T.; Anflous, K.; Ventura-Clapier, R.; Keriel, Ch.; Fontaine, E.; Leverve, X. (1994). ADP diffusion gradients and metabolic oscillatory signals to mitochondria in the heart and liver cells. Gnaiger E., Gellerich F., Wyss M., Steinlechner R., Azzone G. F.. What is controlling life. Modern trends in Biothermokinetics (178−180). . Innsbruck: Innsbruck University Press.

1.1.

1993

Nemirovskaia, T.L.; Shenkman, B.S.; Nekrasov, A.N.; Kuznetsov, A.V.; Saks, V.A. (1993). Effect of training on the structural-metabolic indicators in athletes skeletal muscles. Biokhimiya, 58 (3), 471−479.

1.1.

1993

Saks, V.A.; Vassilyeva, E.V.; Belikova, YU.O.; Kuznetsov, A.V.; Lyapina, A.; Petrova, L.; Perov, N.A. (1993). Retarded diffusion of ADP in cardiomyocytes: Possible role of outer mitochondrial membrane and creatine kinase in cellular regulation of oxidative phosphorylation. Biochimica et Biophysica Acta, 1144 (2), 134−148.

1.1.

1993

Aliev, M.K.; Saks, V. A. (1993). Quantitative analysis of the "phosphocreatine shuttle": I. A probability approach to the description of phosphocreatine production in the coupled creatine kinase - ATP/ADP translocase - oxidative phosphorylation reactions in heart mitochondria. Biochimica et Biophysica Acta, 1143 (3), 291−300.

1.1.

1993

Saks, V.A.; Strumia, E. (1993). Phosphocreatine: Molecular and cellular aspects of the mechanism of cardioprotective action. Current Therapeutical Research, 53 (5), 565−598.

1.3.

1993

Galyautdinov, G.S.; Saks, V.A.; Kots, YA.I.; Vdovenko, L.G. (1993). Clinical application of phosphocreatine (Neoton) in congestive heart failure. I. Evaluation of general clinical efficiency. Il. Cuore, 10 (2), 185−193.

1.1.

1992

Dzhavadov, S.A.; Dzokharidze, T.Z.; Dzhaliashvili, I.V.; Gelfgat, E.S.; Saks, V.A.; Pogacha, G. (1992). Energy metabolism and contractile function of the heart in diabetic cardiomyopathy: effect of ischemia and reperfusion. Biokhimiya, 57 (12), 1917−1929.

1.1.

1992

Korchazkina, O. V.; Lakomkin, V. L.; Veksler, V. I.; Elizarova, G. V.; Saks, V. A.; Kapelko, V. I.; Kupriyanov, V. V. (1992). Metabolic and functional consequances of complete inhibition of creatine kinase by iodoacetamide in the perfused heart. Biokhimiya, 57 (2), 203−213.

1.1.

1992

Branishte, T.A.; Kuznetsov, A.V.; Khuchua, Z.A.; Samko, A.N.; Naumov, V.G.; Semenovsky, M.L.; Belenkov, Iu.N.; Saks, V.A. (1992). Cellular mechanisms of impaired cardiac energetics in patients with dilated cardiomyopathy: decrease in mitochondrial respiration and creatine kinase expression. Kardiologiia, 32 (5), 13−16.

1.1.

1992

Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Korchazhkina, O.V.; Ruuge, E.K.; Saks, V.A. (1992). Functional significance of 2 pathways of energy transport in cardiomyocytes. Kardiologiia, 32 (4), 71−74.

1.1.

1992

Saks, V.A.; Konorev, E.A.; Grigoriants, R.A.; Belenkov, Iu.N. (1992). Biochemistry of normal and ischemic cardiomyocytes: current state of studies. Kardiologiia, 32 (3), 82−91.

1.1.

1992

Kuznetsov, A.V.; Veksler, V.I.; Sharov, V.G.; Dzhavadov, S.A.; Saks, V.A. (1992). Quantitative relatioship between ischemic heart disease and parameters of energy metabolism. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 3, 21−26.

1.1.

1992

Jaliashvili, I.V.; Konorev, E.A.; Medvedeva, N.V.; Lakomkin, V.L.; Saks, V.A. (1992). The role of calcium ions in the molecular mechanism of the protective mechanism of exogenous phosphocreatine. Biokhimiya, 57 (2), 300−311.

1.1.

1992

Saks, V. A.; Dzhaliashvili, I. V.; Konorev, E. A.; Strumia, E. (1992). Molecular and cellular aspects of the cardioprotective mechanism of phosphocreatine. Biokhimiya, 57 (12), 1763−1784.

1.1.

1992

Moibenko, A.A.; Marchenko, G.I.; Kotsuruba, V.N.; Popovich, L.F.; Zarzhevskaya, V.K.; Saks, V.A. (1992). Effect of exogenous phosphocreatine on endothelium endothelium-dependent vascular reactions in immune cardiac injury. Current Therapeutical Research, 52 (6), 791−801.

1.2.

1992

Khuchua, Z.A.; Kuznetsov, A.V.; Vassilyeva, E.V.; Ventura-Clapier, R.; Clark, J.; Steinschneider, A.Ya.; Korchazhkina, O.V.; Lakomkin, V.L.; Branishte, Th.; Ruuge, E.K.; Kapelko, V.I.; Saks, V.A. (1992). The creatine kinase system and cardiomyopathy. The American Journal of Cardiovascular Pathology, 4 (3), 223−234.

1.3.

1992

Saks, V. A.; Ventura-Clapier, R. (1992). Biochemical organization of energy metabolism in muscle. J. Biochem. Organization, 1, 9−30.

3.2.

1992

Saks, V.A.; Kapelko, V.I.; Ruda, M.Y.; Semenovsky, M.L.; Strumia, E. (1992). Phosphocreatine as effective drug in clinical cardiology. P.P.De Deyn, B.Marsecau, V.Stalon and I.A.Qureshi. Guanidino Compounds in Biology and Medicine (239−248). . John Libbey & Company Ltd..

1.1.

1991

Klushnik, T.P.; Spunde, A.Ya.; Yakovlev, A.G.; Khuchua, Z.A.; Saks, V.A.; Vartanyan, M.E. (1991). b21552150Intracellular alterations of the creatine kinase isoforms in brains of schizophrenic patients. Molecular and Chemical Neuropathology, 15 (3), 271−278.

1.1.

1991

Konorev, E.A.; Medvedeva, N.V.; Dzhaliashvili, I.V.; Lakomkin, V.L.; Saks, V.A. (1991). Participation of calcium ions in the molecular mechanism of cardioprotective action of exogenous phosphocreatine. Basic research in cardiology, 86 (4), 327−339.

1.1.

1991

Konorev, E.A.; Medvedeva, N.V.; Dzhaliashvili, I.V.; Stepanov, V.A.; Saks, V.A. (1991). Effects of phosphocreatine and its structural analogues on membranes. Biokhimiya, 56 (9), 1701−1709.

1.1.

1991

Saks, V.A.; Belikova, Yu.O.; Kuznetsov, A.V. (1991). In vivo regulation of mitochondrial respiration in cardiomyocytes: Specific restrictions for intracellular diffusion of ADP. Biochimica et Biophysica Acta, 1074 (2), 302−311.

1.1.

1991

Konorev, E.A.; Sharov, V.G.; Saks, V.A. (1991). Improvement in contractile recovery of isolated rat heart after cardiologic ischemic arrest with endogenous phosphocreatine: Involvement of antiperoxidative effect? Cardiovascular Research, 25 (2), 164−171.

1.1.

1991

Seppet, EK.; Kairane, CB.; Khuchua, ZA.; Kadaya, LY.; Kallikorm, AP.; Saks, VA. (1991). Hormone regulation of cardiac energy-metabolism. 3. Effect of thyroid state on distribution of creatine-kinase isoenzymes and creatine-controlled respiration in cardiac-muscle. Journal of Applied Cardiology, 6 (5), 301−311.

1.1.

1991

Seppet, EK.; Kadaya, LY.; Hata, T.; Kallikorm, AP.; Saks, VA.; Vetter, R.; Dhalla, NS. (1991). Thyroid control over membrane processes in rat-heart. American Journal of Physiology, 261 (4), 66−71.

1.1.

1990

Konorev, E.A.; Saks, A.A.; Sharov, V.G.; Makhotina, L.A. (1990). Oxidative myocardial damage: Protective action of exogenous phosphocreatine. Biulleten eksperimental'noi biologii i meditsiny, 109 (3), 224−226.

1.1.

1990

Belikova, Yu.O.; Kuznetsov, A.V.; Saks, V.A. (1990). Specific restriction for intracellular diffusion of ADP in cardiomyocytes. Biokhimiya, 55 (11), 1944−1957.

1.1.

1990

Seppet, EK.; Kadaya, LY.; Kallikorm, AP.; Saks, VA. (1990). Hormone regulation of cardiac energy-metabolism. 2. The effect of thyroid state on the coupling between the reactions of oxidative-phosphorylation and phosphocreatine synthesis in rat-heart mitochondria. Journal of Applied Cardiology, 5 (5), 367−381.

1.1.

1990

Seppet, EK.; Kadaya, AI.; Kallikorm, AP.; Saks, VA. (1990). Synthesis of phosphocreatine in myocardial mitochondria of hyperthyroid rats. Biochemistry (Moscow), 55 (6), 809−814.

1.1.

1989

Konorev, E.A.; Saks, V.A.; Sharov, V.G.; Yevstigneeva, R.P. (1989). Improvement of contraction and metabolism of rat isolated heart in postischemic reperfusion with phosphocreatine and tocopheryl phosphate and their combinations. Vestnik Akademii Meditsinskikh Nauk SSSR, 12, 55−63.

1.1.

1989

Sharov, V.G.; Beskrovnova, N.N.; Kryzhanovsky, S.A.; Bobkov, J.G.; Saks, V.A.; Kaverina, N.V. (1989). Ultrastructure of Purkinje cells in the subendocardium and false tendons in early experimental myocardial infarction complicated by fibrillation in the dog. Virchows Archiv B-Cell Pathology, 57 (2), 131−139.

1.1.

1989

Kuznetsov, A.V.; Khuchua, Z.A.; Vassilyeva, E.V.; Medvedeva, N.V.; Saks, V.A. (1989). Heart mitochondrial creatine kinase revisited: The outer mitochondrial membrane is not important for coupling of phosphocreatine production to oxidative phosphorylation. Archives of Biochemistry and Biophysics, 268 (1), 176−190.

1.1.

1989

Kuznetsov, A.V.; Veksler, V.I.; Sharov, V.G.; Kapelko, V.I.; Saks, V.A. (1989). Estimation of functional parameters of mitochondria insitu by recording respiration of skinned heart figers. Bulletin of Experimental Biology and Medicine, 107 (2), 174−176.

1.1.

1989

Khuchua, Z.A.; VenturaClapier, R.; Kuznetsov, A.V.; Grishin, M.N.; Saks, V.A. (1989). Alteration in the creatine kinase in the myocardium of the cardiomyopathic hamsters. Biochemical and Biophysical Research Communications, 165 (2), 748−757.

1.3.

1989

Semenovsky, M.L.; Mogilevsky, G.M.; Shumakov, V.I.; Sharov, V.G.; Saks, V.A. (1989). Metabolic protection of myocardium during surgery: Blood cardioplegia in combination with exogenous phosphocreatine. Sov. Med. Rev. A. Cardiol, 2, 233−266.

1.3.

1989

Afonskaya, N.I.; Samarenko, M.B.; Vikhert, A.M.; Cherpachenko, N.M.; Sharov, V.G.; Saks, V.A.; Ruda, M.Ya. (1989). Phosphocreatine in the treatment of patients with acute myocardial infarction. Sov. Med. Rev. A. Cardiol, 2, 267−294.

1.1.

1988

Ruda, M.Ya.; Samarenko, M.B.; Afonskaya, N.I.; Saks, V.A. (1988). Reduction of ventricular arrythmias by phosphocreatine (Neoton) in patients with acute myocardial infarction. American Heart Journal, 116 (2), 393−397.

1.1.

1988

Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Severina, M.Yu.; Veksler, V.I.; Saks, V.A. (1988). The cardiac contractile failure induced by chronic creatine and phosphocreatine deficiency. Journal of Molecular and Cellular Cardiology, 20 (6), 465−479.

1.1.

1988

Kupriyanov, V.V.; Lakomkin, V.L.; Steinschneider, A.Ya.; Severina, M. Yu.; Kapelko, V.I.; Ruuge, E.K.; Saks, V.A. (1988). Relationships between pre-ischemic ATP and glycogen content and post-ischemic recovery of rat heart. Journal of Molecular and Cellular Cardiology, 20 (12), 1151−1162.

1.1.

1988

Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Zueva, M.Yu.; Saks, V.A. (1988). Mechanisms of the cardiac contractile function and energy metabolism adaptation to conditions of chronic depletion of phosphocreatine. Fiziologicheskii Zhurnal, 34 (1), 3−11.

1.1.

1988

Seppet, EK.; Eimre, MA.; Kallikorm, AP.; Saks, VA. (1988). Effect of exogenous phosphocreatine on heart-muscle contractility modulated by hyperthyroidism and extracellular calcium-concentration. Journal of Applied Cardiology, 3 (6), 369−380.

1.3.

1988

Saks, V.A.; Machotina, L.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Kapelko, V.I.; Preobrazhansky, A.N.; Medvedeva, N.V.; Vititnova, M.B.; Kacharava, V.P.; Kryzhanovsky, S.A.; Konorev, E.A.; Pitchugin, V.V.; Sharov, V.G.; Kaverina, N.V. (1988). Sechenov Physiological Journal of the USSR. Bull. Cardiology Research Centre USSR, 2, 42−50.

1.1.

1987

Elizarova, G. V.; Sykhanov, A. A.; Saks, V. A. (1987). Myofibrillar creatine kinase reversible binding to contractile proteins, stoichiometric ratio to myosin and functional significance. Biokhimia, 52 (4), 667−675.

1.1.

1987

Saks, V. A.; Khuchua, Z. A.; Kuznetsov, A. V. (1987). Specific inhibition of ATP-ADP translocase in cardiac mitoplasts by antibodies against mitochondrial creatine kinase. Biochimica et Biophysica Acta, 891 (2), 138−144.

1.1.

1987

Veksler, V. I.; Kuznetsov, A. V.; Sharov, V. G.; Kapelko, V. I.; Saks, V. A. (1987). Mitochondrial respiratory parameters in cardiac tissue a novel method of assessment by using saponin-skinned fibers. Biochimica et Biophysica Acta, 892 (2), 191−196.

1.1.

1987

Kupriyanov, V.V.; Steinschneider, A.Ya.; Lakomkin, V.L.; Zueva, M.Yu.; Kapelko, V.I.; Saks, V.A. (1987). Metabolism of exogenous phosphocreatine and 3-phosphono-2-imino-1-methyl-4-oxoimidazolodine in perfused rat heart during ischemia. Biokhimia, 52 (3), 437−444.

1.1.

1987

Shteinshneider, A.Ya.; Kupriyanov, V.V.; Ruuge, E.K.; Saks, V.A. (1987). 3-Phosphono-2-imino-1-methyl-4-oxoimidazolidine is a competitive substrate of AMP-dephosphorylating enzymes in rat heart cytosol. Biokhimia, 52 (4), 577−583.

1.1.

1987

Kapelko, V. I.; Saks, V. A.; Novikova, N. A.; Golikov, M. A.; Kupriyanov, V. V.; Popovoch, M. I. (1987). Adaptation of cardiac contractile function to conditions of chronic energy. Journal of Molecular and Cellular Cardiology, 19 (Suppl IV), 61.

1.1.

1987

Saks, V. A.; Kuznetsov, A. V.; Javadov, S. A.; Kupriyanov, V. V.; Sharov, V. G.; Veksler, V. I.; Kapelko, V. I. (1987). Contents of high energy phosphates and rates of mitochondrial oxidative reactions: significance for cardiac contractile function. Journal of Molecular and Cellular Cardiology, 19 (Suppl. IV), 60.

1.1.

1987

Khuchua, Z.A.; Kuznetsov, A.V.; Chernousova, G.B.; Lyulina, N.V.; Saks, V.A. (1987). Immunochemical study on the structural basis of functional coupling between creatine kinase and ATP-ADP translocase in heart mitochondria. Biologicheskie Membrany, 4 (4), 415−425.

1.1.

1987

Ventura-Clapier, R.; Saks, V. A.; Vassort, Guy; Lauer, Claudine; Elizarova, G. V. (1987). Reversible MM-creatine kinase binding to cardiac myofibrils. American Journal of Physiology-Cell Physiology, 253 (22), 444−455.

1.1.

1987

Ventura-Clapier, R.; Veksler, V. I.; Elizarova, G. V.; Mekfi, H.; Levitskaya, E. L.; Saks, V. A. (1987). Contractile properties and creatine kinase activity of myofilaments following ischemia and reperfusion of the rat heart. Biochemical Medicine and Metabolic Biology, 38 (3), 300−310.

1.1.

1987

Sharov, V. G.; Saks, V. A.; Kupriyanov, V. V.; Lakomkin, V. L.; Kapelko, V. I.; Steinschneider, A. Ya.; Javadov, S. A. (1987). Protection of ischemic myocardium by exogenous phosphocreatine (Neoton): I. Morphological and 31p-NMR studies. Journal of Thoracic and Cardiovascular Surgery, 94 (5), 749−761.

1.1.

1987

Kupriyanov, V. V.; Lakomkin, V. L.; Steinschneider, A. Ya.; Novikova, N. A.; Severina, M. Yu.; Kapelko, V. I.; Saks, V. A. (1987). The role of phosphocreatine and ATP in contraction of normal and ischemic heart. Biomedica Biochimica Acta, 46, 493−498.

1.1.

1987

Kupriyanov, V. V.; Lakomkin, V. L.; Kapelko, V. I.; Steinschneider, A. Ya.; Ruuge, E. K.; Saks, V. A. (1987). Dissociation of adenosine triphosphate levels and contractile function in isovolumic hearts perfused with 2-deoxyglucose. Journal of Molecular and Cellular Cardiology, 19 (8), 729−744.

1.1.

1987

Semenovsky, M. L.; Shumakov, V. I.; Sharov, V. G.; Mogilevsky, G. M.; Asmolovsky, A. V.; Makhotina, L. A.; Saks, V. A. (1987). Protection of ischemic mytocardium by exogenous phosphocreatine. II. Clinical, ultrastructural and biochemical evaluations. Journal of Thoracic and Cardiovascular Surgery, 94 (5), 762−769.

1.1.

1987

Seppet, EK.; Kallikorm, AP.; Javadov, SA.; Preobrazhensky, AN.; Lakomkin, VA.; Saks, VA. (1987). Energy-dependence of heart contractility impairment in conditions of calcium overload. Kardiologiya, 27 (7), 72−76.

3.1.

1987

Saks, V. A.; Kapelko, V. I.; Kupriyanov, V. V.; Khuchua, Z. A.; Lakomkin, V. L.; Novikova, N. A.; Ruuge, E. K.; Sharov, V. G.; Steinschneider, A. Ya.; Zueva, M. Yu. (1987). Control of energy transport in cardiac muscle. Dissociation of ATP levels from contractile function: cardiac failure due to phosphocreatine dediciency. Dhalla N. S., Pierce G. N., Beamish R. E.. Heart function & Metabolism (377−395). . Boston: Martinus Nijhoff Publishers.

3.2.

1987

Saks, V. A.; Bobkov, I. G. (1987). Creatine phosphate: biochemistry, pharmacology and clinical efficiency. Strumia, E... . Torino: Edizoni Minerva Medica.

3.2.

1987

Lakomkin, V. L.; Steinschneider, A. Ya.; Novikova, N. A.; Kapelko, V. I.; Saks, V. A. (1987). Phosphocreatine, ATP in energy supply for cardiac contraction. Metabolism and Development of Nervous System (276−281). . Chichester; Prague: Academia.

3.2.

1987

Kupriyanov, V. V.; Balaban, R. S.; Steinschneider, A. Ya.; Lakomkin, V. L .; Ruuge, E. K.; Smirnov, V. N.; Saks, V. A. (1987). 31p-NMR study of creatine kinase reaction mechanism in vitro and in vivo. Smirnov V. N ., Katz A .. Myocardial metabolism Cardiology reviews, suppl. 2 (120−130). . London: Harwood Academic Publishers.

3.2.

1987

Saks, V. A.; Sharov, V. G.; Kupriyanov, V. V.; Krizhanovsky, S. A.; Semenovsky, M. L.; Mogilevsky, G. M.; Lakomkin, V. L.; Steinschneider, A. Ya.; Preobrazhensky, A. N.; Javadov, S. A.; Anyukhovsky, E. P.; Beskrovnova, N. A.; Rosenschtraukh, L. V.; Kaverina, N. V. (1987). Phosphocreatine and related compounds: protective action on the ischemic myocardium. Smirnov V. N., Katz A.. Myocardial metabolism. Cardiology reviews, suppl. 2 (189−200). . London: Harwood Academic Publishers.

3.2.

1987

Saks, V. A.; Javadov, S. A.; Pozin, E.; Preobrazhensky, A. N. (1987). Biochemical basis of the protective action of phosphocreatine on the ischemic myocardium. L. D` Alessandro Case. Heart surgery-87 (155−170). . Roma: Editrice Scietifica Internationale.

1.1.

1986

Kupriyanov, V. V.; Lyulina, N. V.; Steinschneider, A. Ya.; Zueva, M. Yu.; Saks, V. A. (1986). Creatine kinase - catelyzed ATP-phosphocreatine exchange. Comparison of 31p-NMR saturation transfer technique and radioisotope tracer methods. FEBS Letters, 208 (1), 89−93.

1.1.

1986

Dzhavadov, S. A.; Preobrazhensky, A. N.; Saks, V. A. (1986). Effect of phosphocreatine on the lysophosphoglyceride level during total ischemia of rat myocardium. Biokhimia, 51 (4), 668−674.

1.1.

1986

Preobrazhensky, A.N.; Javadov, S.A.; Saks, V.A. (1986). Study on the hypothetical mechanism of protective effect of phosphocreatine on ischemic myocardium. Biokhimia, 51 (4), 675−683.

1.1.

1986

Saks, V.A.; Vassort, G.; Ventura-Clapier, R. (1986). Reversible MM-creatine kinase binding to Triton-treated isolated rat papillary muscles. The Journal of Physiology, 377, 117.

1.1.

1986

Anyukhovsky, E. P.; Javadov, S. A.; Preobrazhensky, A. N.; Beloshapko, G. G.; Rosenshtraukh, L. V.; Saks, V.A. (1986). Effect f phosphocreatine and related compounds on the phospholipid metabolism of ischemic heart. Biochemical Medicine and Metabolic Biology, 35 (3), 327−334.

1.1.

1986

Chazov, E.I.; Semenovsky, M.L.; Smirnov, V.N.; Shumakov, V.I.; Saks, V.A.; Sharov, V.G.; Mogilevsky, G.M.; Severin, V.V.; Asmolovsky, A.V.; Makhotina, L.A. (1986). Morphological and biochemical criteria of the efficiency of clinical application of phosphocreatine (Neoton) for intraoperational protection of myocardium. Fiziologicheskii Zhurnal, 32 (1), 3−13.

1.1.

1986

Sharov, V. G.; Afonskaya, N. I.; Ruda, M. Y.; Cherpachenko, N. M.; Posin, G. Ya.; Markosyan, R. A.; Shepeleva, I. I.; Samarenko, M. B.; Saks, V. A. (1986). Protection of ischemic myocardium by exogenous phosphocreatine (Neoton): Pharmacokinatics of phosphocreatine, reduction of infarct size, stabilization of sarcolemma of ischemic cardiomyocytes and antithrombotic action. Biochemical Medicine and Metabolic Biology, 35 (1), 101−114.

1.1.

1986

Kuznetsov, A. V.; Saks, V. A. (1986). Affinity modification of creatine kinase and ATP-ADP translocase in heart mitochondria determination of their molar stoichiometry. Biochemical and Biophysical Research Communications, 134 (1), 359−366.

1.1.

1986

Saks, V. A.; Khuchua, Z. A.; Kuznetsov, A. V.; Veksler, V. I.; Sharov, V. G. (1986). Heart mitochondria in physiological salt solution not ionic strength but salt composition is important for association of creatine kinase with the inner membrane surface. Biochemical and Biophysical Research Communications, 139 (3), 1262−1271.

3.1.

1986

Saks, V. A.; Kuznetsov, A. V.; Khuchua, Z.; Kupriyanov, V. V. (1986). Compartmentation of adenine nucleotides and phosphocreatine shuttle in cardiac cells some new evidence. Brautbar N.. Advances in experimental medicine and biology (103−116). . New York: Plenum Press.

3.2.

1986

Belenkov, Yu. N.; Saks, V. A.; Sharov, V. G.; Semenovsky, M. L.; Mogilevsky, G. M.; Afonskaya, N. I.; Ruda, M. Y.; Samarenko, M. B. (1986). Phosphocreatine action on ischemic myocardium experimental research and clinical trial. Mason Ztacia. Progress in Molecular Genetics and Frontiere della Cardiologia (111−133). . Milano: x.

5.1.

1986

Seppet, E.; Kallikorm, A.; Saks, V.; Antaloczy, Z. (1986). Effect of phosphocreatine on hyperthyroid rat-heart contractility. Acta Physiologica Hungarica, 68, 282−282.

1.1.

1985

Rosenshtraukh, L. V.; Saks, V. A.; Anyukovsky, E. P.; Beloshapko, G. G.; Yushmanova, A. V. (1985). The antiarrhythmic action of phosphocreatine in acute myocardial ischemia. Biochemical Medicine, 34 (1), 120−128.

1.1.

1985

Seppet, EK.; Aodyaan, AJ.; Kallikorm, AP.; Chernousova, GB.; Lyulina, NV.; Sharov, VG.; Severin, VV.; Popovich, MI.; Saks, VA. (1985). Hormone regulation of cardiac energy-metabolism. 1. Creatine transport across cell-membranes of euthyroid and hyperthyroid rat-heart. Biochemical Medicine, 34 (3), 267−279.

1.1.

1985

Saks, V. A.; Kuznetsov, A. V.; Kupriyanov, V. V.; Miceli, M. V.; Jacobus, W. J. (1985). Creatine kinase of rat heart mitochondria. The demostration of functional coupling to oxidative phosphorylation in an inner membrane-matrix preparation. Journal of Biological Chemistry, 260 (12), 7757−7764.

1.1.

1985

Mogilevsky, G.M.; Sharov, V.G.; Saks, V.A.; Semenovsky, M.L. (1985). Structural-biochemical characterization of the efficiency of the intraoperational myocardium protection. Arkhiv Patologii, 47 (6), 24−29.

1.3.

1985

Kupriyanov, V.V.; Steinschneider, A.Ya.; Lakomkin, V.L.; Ruuge, E.K.; Kapelko, V.I.; Saks, V.A. (1985). 31P-NMR study of protective effect of phosphocreatine on ischemic myocardium under cardioplegia. Bull. Cardiology Research Centre USSR, 1, 14−19.

3.2.

1985

Saks, V. A.; Sharov, G.; Kupriyanov, V. V.; Semenovsky, M. L.; Mogilevsky, G. M.; Lakomkin, V. L.; Steinschneider, A. Ya.; Afonskaya, N. I.; Ruda, M.Ya.; Samarenko, M. B. (1985). Phosphocreatine and myocardial protection: biochemical, pharmacological and clinical aspects. Conoscere e curare il cuore 85 (348−373). . Rome: Schiaparelli Farmaceutici.

3.4.

1985

Saks, V. A.; Kupriyanov, V. V.; Ventura-Clapier, R. (1985). Mechanism of energy supply for contraction: biochemical and NMR studies. Proceedings of the 16th FEBS Congress, part A. VNU Science press, 281−290.

1.1.

1984

Kupriyanov, V. V.; Steinschneider, A. Ya.; Ruuge, E. K.; Kapelko, V. I.; Zueva, M. Ya.; Lakomkin, V. L.; Smirnov, V. N.; Saks, V. A. (1984). Regulation of energy flux through the creatine kinase reaction in vitro and in perfused rat heart. 31p-NMR Studies. Biochimica et Biophysica Acta, 805 (4), 319−331.

1.1.

1984

Saks, V. A.; Ventura-Clapier, R.; Khuchua, Z. A.; Preobrazhensky, A. N.; Emelin, I. V. (1984). Creatine kinase in regulation of heart function and metabolism. I Further evidence for compartmentation of adenine nucleotides in cardiac myofibrillar and sarcolemmal coupled ATPase-creatine kinase systems. Biochimica et Biophysica Acta, 803 (4), 254−264.

1.1.

1984

Seppet, EK.; Adoyaan, AI.; Kallikorm, AP.; Chernousova, GV.; Lyulina, NV.; Severin, VV.; Popovich, MI.; Saks, VA. (1984). Hyperthyroid cardiomyopathy - abnormalities in creatine transport and hypersensitivity to ischemic-injury. Vestnik Akademii Meditsinskikh Nauk SSSR, 10, 48−56.

1.2.

1984

Saks, V. A.; Sharov, V. G.; Kupriyanov, V. V.; Smirnov, V. N.; Semenovsky, M. L. (1984). Protective action of phosphocreatine on ischemic myocardium. Journal of Molecular and Cellular Cardiology, 16 (Suppl. 2), 113.

3.1.

1984

Saks, V. A.; Chernousova, G. B.; Lyulina, N. V.; Khuchua, Z. A.; Preobrazhensky, A. N.; Ventura-Clapier, R. (1984). Role of multienzyme complexes in intracellular compartmentation of adenine nucleotides and in regulation of cardiac energy metabolism. Cellular and molecular aspects of the regulation of the heart (41−48). . Berlin: Akademie Verlag Gmbh.

1.1.

1983

Gellerich, F. N.; Schlame, M.; Saks, V. A. (1983). Creatine kinase of heart mitochondria: no changes in its kinetic properties after inhibition of the adenine nucleotide translocator. Biomedica Biochimica Acta, 42 (10), 1335−1337.

1.1.

1983

Kupriyanov, V. V.; Preobrazhensky, A. N.; Saks, V. A. (1983). Mechanism of passive Ca2+ permeability of vesicular sarcolemmal preparations from rat hearts. Biochimica et Biophysica Acta, 728 (2), 239−253.

1.1.

1983

Kupriyanov, V. V.; Steinschneider, A. Ya.; Ruuge, E. K.; Smirnov, V. N.; Saks, V. A. (1983). 31p-NMR SPECTRUM of phosphocreatine: ducterium-induced splitting of the signal. Biochemical and Biophysical Research Communications, 114 (3), 1117−1125.

1.1.

1982

Preobrazhenskii, A. N.; Kupriyanov, V. V.; Saks, V. A.; Grosse, R.; Spitzer, E. (1982). Effect of cardenolids and sodium ion gradient on ATP - dependent Ca2+ accumulation in cardiac sarcolemmal vesicles. Biokhimia, 47 (1), 126−136.

1.1.

1982

Gellerich, F.; Saks, V. A. (1982). Control of heart mitochondrial oxygen consumption by creatine kinase: the importance of enzyme localization. Biochemical and Biophysical Research Communications, 105 (4), 1473−1481.

1.2.

1982

Saks, V. A.; Kupriyanov, V. V. (1982). Intracellular energy transport and control of cardiac contraction. Advances in Myocardiology, 3, 475−497.

1.2.

1982

Preobrazhensky, A. N.; Saks, V. A. (1982). The cardiac sarcolemmal protein kinase reaction. Kinetic characteristics and sensitivity to cyclic AMP. Advances in Myocardiology, 3, 273−288.

1.1.

1981

Kupriyanov, V. V.; Elizarova, G. V.; Saks, V. A. (1981). Determination of molar content of creatine kinase in cardiac mitochondria by SH - reagents. Biokhimia, 46 (5), 930−941.

1.1.

1981

Preobrazhensky, A.N.; Saks, V.A. (1981). Some properties of the reaction catalyzed by protein kinase bound to cardiac sarcolemma. Biokhimia, 46 (9), 1681−1693.

1.1.

1981

Kupriyanov, V. V.; Preobrazhensky, A. N.; Saks, V. A. (1981). Study of passive Ca2+ permeability of ventricular sarcolemmal preparations from myocardium. Biokhimia, 46 (10), 1863−1879.

1.1.

1980

Saks, V. A.; Kupriyanov, V. V.; Elizarova, G. V.; Jacobus, W. E. (1980). Studies of energy transport in heart cells. The importance of creatine kinase localization for the coupling of mitochondrial phosphorylcreatine production to oxidative phosphorylation. Journal of Biological Chemistry, 255 (2), 755−763.

1.1.

1980

Kupriyanov, V.V.; Panasenko, N.A.; Saks, V.A. (1980). The kinetics of the interaction of analogs of guanidine substrates with muscle creatine kinase. Биоорганическая химия, 6 (1), 116−137.

1.1.

1980

Saks, V.A.; Smirnov, V.N. (1980). Molecular mechanisms of changes in myocardial energy metabolism in pathological conditions. Kardiologiia, 20 (5), 10−12.

1.1.

1980

Grosse, R.; Spitzer, E.; Kupriyanov, V. V.; Saks, V. A.; Repke, K. K. H. (1980). Coordinate interplay between (n+, K+ ) antiport across the membrane of resieles forward from the plasme membrane of cardiac muscle cells. Biochimica et Biophysica Acta, 603 (1), 142−156.

1.1.

1980

Kupriyanov, VV.; Seppet, EK.; Emelin, IV.; Saks, VA. (1980). Phosphocreatine production coupled to the glycolytic reactions in the cytosol of cardiac-cells. Biochimica et Biophysica Acta, 592 (2), 197−210.

3.2.

1980

Rosenshtraukh, L. V.; Saks, V. A.; Sharov, V. G.; Yuryavichyus, I. A.; Chazov, E. I. (1980). Regulation of mechanical and electrical activity of the hypodynamic myocardium by creatine phosphate. Energy transport, protein synthesis and hormonal control of heart metabolism (89−112). . Betheda: US Department of Health and Human Services.

3.2.

1980

Chazov, E. I.; Smirnov, V. N.; Saks, V. A.; Rosenshtraukh, L. V.; Lipina, N. V.; Levitsky, D. O. (1980). Energy metabolism and ion fluxes across cardiac membranes. M. Tajuddin, P. K. Das, M. Tariq, N. S. Dhalla. Advances in myocardiology (1). . Baltimore: University Park Press.

3.2.

1980

Saks, V. A.; Kupriyanov, V. V.; Elizarova, G. V.; Seppet, E. K.; Jacobus, W. E. (1980). Regulation of phosphorylcreatine synthesis in myocardial cells: the coupling of transphosphorylation to glycosis and mitochondrial oxidative phosphorylation and the significance of creatine kinase compartmentation. Energy transport, protein synthesis and hormonal control of heart metabolism (89−112). . Betheda: US Department of Health and Human Services. (NIH Publication ; N 80 - 2017).

3.2.

1980

Saks, V.A. (1980). Creatine kinase isoenzymes and control of cardiac contraction. Jacobus J. W., Ingwall J.. Heart creatine kinase: the integration of isoenzymes for energy distribution (109−124). . Baltimore: Williams & Wilkins.

1.1.

1979

Rosenshtraukh, L. V.; Saks, V. A.; Yuriavichus, I. A.; Nesterenko, N. V.; Undrovinas, A. I.; Smirnov, V. N.; Chazov, E. I. (1979). Effect of creatine phosphate on the slow inward calcium current, action potential and the contractile force of frog attrium and ventricle. Biochemical Medicine, 21 (1), 1−15.

1.1.

1979

Sharov, V.G.; Shepeleva, I.I.; Saks, V.A. (1979). Electron microscopic investigation of permeability of the sarcolemma of rat cardiac myocytes during acute anoxia of the myocardium. Bulletin of Experimental Biology and Medicine, 88 (8), 917−921.

1.1.

1979

Kupriyanov, V.V.; Seppet, E.K.; Emelin, I.V.; Saks, V.A. (1979). Steady state kinetics of pyruvate kinase from muscle. Biokhimia, 44 (1), 104−115.

1.1.

1979

Erashova, N.S.; Saks, V.A.; Sharov, V.G.; Lyzlova, S.N. (1979). Creatine kinase from muscle cell nuclei. Biokhimia, 44 (2), 372−378.

1.1.

1979

Saks, V.A.; Kats, V.M.; Vetter, R.; Lylina, V.N.; Shell, W. (1979). The effect of calcium ions on the creatine kinase systems of myocardial cells. Biokhimia, 44, 1600−1611.

1.1.

1979

Saks, VA.; Seppet, EK.; Smirnov, VN. (1979). Does oxidative-phosphorylation increase the rate of creatine-phosphate synthesis in heart-mitochondria or not. Journal of Molecular and Cellular Cardiology, 11 (12), 1265−1273.

1.1.

1979

Kupriyanov, VV.; Seppet, EK.; Emelin, IV.; Saks, VA. (1979). Steady-state kinetics of muscular pyruvate-kinase. Biochemistry (Moscow), 44 (1), 87−95.

1.3.

1979

Rosenshtraukh, L. V.; Saks, V. A.; Yuriavichus, I. A.; Nesterenko, N. V.; Undrovinas, A. I.; Smirnov, V. N. (1979). Effect of creatine phosphate on the slow inward calcium current, action potential, and the contractile force of frog atrium and ventricle. Fisioliologitšeski Zhurnal SSSR, 65, 405−413.

1.3.

1979

Shepeleva, I.I.; Saprygin, D.B.; Saks, V.A.; Kramer, A.A.; Kashtelyan, L.S. (1979). Experimental substantiation of myocardial affection visualization by means of pyrophosphate-99m Tc. Meditsinskaya Radiologiya, 3, 16−22.

1.1.

1978

Kupriyanov, V.V.; Seppet, E.K.; Saks, V.A. (1978). Creatine phosphate synthesis coupled to the glycolytic reactions in heart cells cytosol. Biokhimia, 43 (8), 1468−1476.

1.1.

1978

Saks, V. A.; Rosenshtraukh, L. V.; Smirnov, V. N.; Chazov, E. I. (1978). Role of creatine phosphokinase in cellular function and metabolism. Canadian Journal of Physiology and Pharmacology, 56 (5), 691−706.

1.1.

1978

Rosenshtraukh, L. V.; Saks, V. A.; Undrovinas, A. I.; Chazov, E. I.; Smirnov, V. N.; Sharov, V. G. (1978). Studies of energy transport in heart cells. The effect of creatine phosphate on the frog ventricular contractile force and action potential duration. Biochemical Medicine, 19 (2), 148−164.

1.1.

1978

Levitsky, D. O.; Levchenko, T. S.; Saks, V. A.; Sharov, V. G.; Smirnov, V. N. (1978). The role of creatine phosphokinase in supplyng energy for the calcium pump system of heart sarcoplasmic reticulum. Membrane Biochemistry, 2 (1), 81−96.

1.1.

1978

Erashova, N. S.; Saks, V. A.; Sharov, V. G.; Lyzlova, S. N. (1978). Creatine kinase bound to cardiac cells nuclei. Biochemical and Biophysical Research Communications, 82 (4), 1217−1222.

1.1.

1978

Sharov, V.G.; Orlova, Z.R.; Saks, V.A. (1978). Ultrastructural bases of acute cardiac insufficiency not associated with rhythm disorders. Arkhiv Patologii, 40 (10), 3−14.

1.1.

1978

Seppet, EK.; Kupriyanov, VV.; Saks, VA. (1978). Adenylate kinase from heart. 2. Steady-state kinetics of reverse reaction (adp formation). Bioorganicheskaya Khimiya, 4 (1), 95−108.

1.1.

1978

Kupriyanov, VV.; Seppet, EK.; Saks, VA. (1978). Creatine-phosphate synthesis coupled with glycolytic reactions in myocardial-cell cytosol. Biochemistry (Moscow), 43 (8), 1153−1161.

1.1.

1977

Saks, V.A.; Seppet, E.K.; Lyulina, N.V. (1977). A comparative study of the role of creatine phosphokinase isoenzymes in energy metabolism of skeletal and heart muscle. Biokhimia, 42 (4), 579−588.

1.1.

1977

Levitsky, D.O.; Levchenko, T.S.; Saks, V.A.; Sharov, V.G.; Smirnov, V.N. (1977). The functional coupling between Ca2+ -ATPase and creatine phosphokinase in heart muscle sarcoplasmic reticulum. Biochimia, 42 (10), 1766−1773.

1.1.

1977

Sharov, V. G.; Saks, V. A.; Smirnov, V. N.; Chazov, E. I. (1977). An electron microscopic histochemical investigation of creatine phosphokinase in heart cells. Biochimica et Biophysica Acta, 468 (3), 495−501.

1.1.

1977

Saks, V. A.; Lipina, N. V.; Sharov, V. G.; Smirnov, V. N.; Chazov, E. I.; Grosse, Richard (1977). The localization of the MM isoenzyme of creatine phosphokinase on the surface membrane of myocardial vells and its functional coupling to analain-inhibited (Na+, K+ ) ATPase. Biochimica et Biophysica Acta, 465 (3), 550−558.

1.1.

1977

Kupriyanov, VV.; Seppet, EK.; Saks, VA. (1977). Adenylate kinase from heart. 1. Kinetics of forward reaction. Bioorganicheskaya Khimiya, 3 (12), 1682−1695.

1.1.

1977

Saks, VA.; Seppet, EK.; Lyulina, NV. (1977). Comparative investigation of role of creatine-phosphokinase isoenzymes in energy-metabolism of skeletal-muscles and myocardium. Biochemistry (Moscow), 42 (4), 445−452.

1.3.

1977

Rosenshtraukh, L.V.; Saks, V.A.; Undrovinas, A.I.; Yuryavichus, A.I.; Yushmanova, A.V.; Sharov, V.G.; Seppet, E.K.; Smirnov, V.N.; Chazov, E.I. (1977). The role of creatine phosphokinase systems in regulation of the force of contraction of frog heart muscle. Fisioliologitšeski Zhurnal SSSR, 63, 681−688.

1.1.

1976

Saks, V. A.; Lipina, N. V.; Smirnov, V. N.; Chazov, E. I. (1976). Studies of energy transport in heart cells. The functional coupling between mitochondrial creatine phosphokinase and ATP-ADP translocase: kinetic evidence. Archives of Biochemistry and Biophysics, 173 (1), 34−41.

1.1.

1976

Saks, V. A.; Chernousova, G. B.; Vetter, R.; Smirnov, V. N.; Chazov, E. I. (1976). Kinetic propenties and the functional role of particulate MM-isoenzyme of creatine phosphokinase bound to heart muscle myofibrilis. FEBS Letters, 62 (3), 293−296.

1.1.

1976

Saks, V.A.; Lipina, N.V.; Chernousova, G.B.; Sharov, V.G.; Smirnov, V.N.; Grosse, R. (1976). Functional coupling of MM isoenzyme of creatine kinase with MgATPase of myofibrils and Na,K-ATPase of plasmatic membrane of heart cells. Biochimia, 41 (12), 2099−2109.

1.1.

1976

Saks, V. A.; Lipina, N.V.; Lyulina, N.V.; Chernousova, G.B.; Vetter, R.; Smirnov, V.N.; Chazov, E.I. (1976). Functional characteristics of creatine kinase reactions in heart mitochondria and myofibrils. Biochimia, 41 (8), 1450−1470.

1.1.

1976

Saks, V. A.; Rosenshtraukh, L. V.; Undrovinas, A. I.; Smirnov, V. N.; Chazov, E. I. (1976). Studies of energy transport in heart cells. Intracellular creatine content as a regulatory factor of frog heart energetics and fonce of contraction. Biochemical Medicine, 16 (1), 21−36.

1.3.

1976

Rosenshtraukh, L.V.; Saks, V.A.; Undrovinas, A.I.; Yushmanova, A.V.; Smirnov, V.N.; Chazov, E.I. (1976). A study of the dependence of the frog heart muscle contractile force àn intracellular energy transport processes. Fisioliologitšeski Zhurnal SSSR, 62, 1199−1210.

1.1.

1975

Saks, V. A.; Chernousova, G. B.; Gukovsky, D. E.; Smirnov, V. N.; Chazov, E. I. (1975). Studies of Energy Transport in heart cells. Mitochondrial isoenzyme of creatine phosphokinase: kinetic properties and regulatort action of Mg 2+ ions. European Journal of Biochemistry, 57 (1), 273−290.

1.3.

1975

Saks, V.A.; Lyulina, N.V.; Chernousova, G.B.; Voronkov, Yu.I.; Smirnov, V.N.; Chazov, E.I. (1975). Study of the role of mitochondrial creatine kinase in the process of energy transport in the heart cells. Kardiologiia, 9, 103−110.

1.1.

1974

Saks, V. A.; Chernousova, G. B.; Voronkov, U. I.; Smirnov, V. N.; Chazov, E. I. (1974). Study of energy transport mechanism in myocardial cells. Circulation Research, 34-35 (Suppl. III), 138−149.

1.3.

1974

Saks, V.A.; Voronkov, Yu.I. (1974). Diagnostic significance of serum creatine kinase activity in myocardial infarction. Terapevticheskii Arkhiv, 6, 32−38.

Viimati uuendatud

10.08.2021

Valdur Saks

https://www.etis.ee/CV/Valdur_Saks/eng

Date of birth

3.09.1943

Phone

639 8363

Phone

644 8643

E-mail

Palun lisage siia ainult üks aadress. Sellele meiliaadressile saadetakse ETISe teated (nt rahastusotsused, andmete kinnitamisega seotud info).

valdur.saks@ujf-grenoble.fr

Career

Institutions and positions

Institute of Cybernetics, Academy of Sciences of Estonia, junior research scientist 1970-1971

Moscow University, department of Chemistry, junior research scientist 1971-1972

Moscow Cardiocenter, senior research scientist 1972-1981

Moscow Cardiocenter, head of the laboratory of Bioenergetics 1981-1993

National Institute of Chemical Physis and Biophysics, head of the laboratory of Bioenergetics 1993 until today

Joseph Fourier University, Grenoble, Professor of the laboratory of Physiology of the Heart Cell 1994 until today

University of Pennsylvania, Philadelphia, USA, 1975-1978

John Hopkins University, Baltimore, USA, 1978-1981

Universite Paris-Sud, Orsay, France repeatedly in years 1981-1993

Work in cooperation:

01.01.2015–31.12.2016

National Institute of Chemical Physics and Biophysics, Senior Research Fellow (0,10)

01.09.2007–31.12.2014

National Institute of Chemical Physics and Biophysics, leading researcher (0,50)

Education

higher, Moscow University

R&D related managerial and administrative work

2010−...

academic editor of the journal PLoS One

Member of the Academy of Sciences of Estonia 1993

International Society for Heart Research, member of the executive committee

American Heart Association, Basic Science Council

International Federation of Cardiological Societies

Biochemical Society of Russia

American Physiological Society

American Biophysical Society

Participation in editorial board:

Journal of Molecular and Cellular Cardiology, USA

Il Cuore, Italy

Cardioscience, Italy

Journal of Physiology, Poland

Qualifications

Academic degrees

Valdur Saks, Doctor's Degree, 1971, (sup) I. V. Berezin, Oksüdeeriva fosforüleerimise süsteemi stabiliseerimine tema funktsioneerimisel (Stabilisation of the system of oxidative phosphorylation by its functioning), Moskva Ülikool.

Honours & awards

2008, Valdur Saks, 2008, Yearly Award, Biosciences and Environment; National Science Award

2006, Valdur Saks, The White Star Order 4th Class

Fields of research

ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry

Additional information

Candidate in chemistry
Doctor in biology 1971 Moscow University
1981 Moscow Cardiocenter

Completed projects

Source of funding	Number	Title	Project start	Project end	Principal investigator	R&D institutions	Funding by financier
Institutional Research Funding (IUT)	IUT23-1	Integreeritud energeetilise metabolismi regulatsioonimehhanismid kasvaja- ning lihasrakkudes.	01.01.2014	31.12.2019	Tuuli Käämbre	National Institute of Chemical Physics and Biophysics	1 013 400 EUR
Estonian Science Foundation Research Grant (ETF)	ETF8987	Vähirakkude bioenergeetilise profiili määramine diagnostikas ja ravis.	01.01.2012	31.12.2015	Tuuli Käämbre	National Institute of Chemical Physics and Biophysics	69 600 EUR

Dissertations under supervision

Title	Person supervised	Degree	Supervisor	Defence status	Year of defence	R&D institutions
Soolevähi metaboolne remodelleerimine: muutused energiavoogudes	Kaldma, Andrus	Doctor's Degree	Tuuli Käämbre; Natalja Timohhina	Defended	2017	Tallinn University of Technology

Andrus Kaldma, Doctor's Degree, 2017, (sup) Tuuli Käämbre; Natalja Timohhina, Soolevähi metaboolne remodelleerimine: muutused energiavoogudes (Metabolic remodeling of human colorectal cancer: alterations in energy fluxes), Tallinn University of Technology Faculty of Science.

Eesti Teadusinfosüsteem

Valdur Saks

Teenistuskäik

Kvalifikatsioon

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Valdur Saks

Career

Qualifications

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Otsi projekti

Eesti Teadusinfosüsteem

Valdur Saks

Teenistuskäik

Kvalifikatsioon

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Valdur Saks

Career

Qualifications

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Otsi projekti

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Otsi programmi