Valdur Saks

https://www.etis.ee/CV/Valdur_Saks/est
3.09.1943
639 8363
644 8643
valdur.saks@ujf-grenoble.fr

Teenistuskäik

Töökohad ja ametid
Eesti TA Küberneetika Instituut, noorem teaduslik töötaja 1970-1971
Moskva Ülikooli keemiateaduskonna noorem teaduslik töötaja 1971-1972
Moskva Kardiokeskuse vanem teaduslik töötaja 1972-1981
Moskva Kardiokeskuse bioenergeetika laboratooriumi juhataja 1981-1993
Eesti TA Keemilise ja Bioloogilise Füüsika Instituudi Bioenergeetika laboratooriumi juhataja k.t. - 1993 kuni tänaseni
Grenoble'i Joseph Fourier Ülikooli Südameraku füsioloogia laboratooriumi titulaarprofessor, 1994 - kuni tanaseni
Töötanud lühiajaliselt koostööprogrammide läbiviimisel: University of Pennsylvania, Philadelphia, USA, 1975-1978
John Hopkinsi Ülikoolis Baltimore'is, USA, 1978-1981
Universite Paris-Sud, Orsay, France korduvalt aastatel 1981-1993
01.01.2015–31.12.2016   
Keemilise ja Bioloogilise Füüsika Instituut, Vanemteadur (0,10)
01.09.2007–31.12.2014   
Keemilise ja Bioloogilise Füüsika Instituut, Juhtivteadur (0,50)
1996–01.09.2007   
Keemilise ja Bioloogilise Füüsika Instituut, Vanemteadur (0,50)
 
 
Haridustee
kõrgem, Moskva Ülikool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2010−...   
ajakirja PLoS One akadeemiline toimetaja
1993 Eesti Teaduste Akadeemia akadeemik
International Society for Heart Research, Täitevkomitee liige
American Heart Association, Basic Science Council
International Federation of Cardiological Societies
Venemaa Biokeemia Ühing
American Physiological Society
American Biophysical Society
Osavõtt väljaannete toimetamisest:
Journal of Molecular and Cellular Cardiology, USA
Il Cuore, Italy
Cardioscience, Italy
Journal of Physiology, Poland

Kvalifikatsioon

Teaduskraadid
Valdur Saks, doktorikraad, 1971, (juh) I. V. Berezin, Oksüdeeriva fosforüleerimise süsteemi stabiliseerimine tema funktsioneerimisel, Moskva Ülikool.
 
 
Teaduspreemiad ja tunnustused
2008, Valdur Saks, Riigi teaduspreemia uurimuste tsükli „ Molekulaarne süsteemne bioenergeetika” eest
2006, Valdur Saks, Valgetähe orden, 4 . klass
1988, Valdur Saks, NSVL Riiklik Preemia 1978ÜRO ja UNICEF'i rahvusvaheline preemia "Research for Development"
 
 
Teadustöö põhisuunad
VALDKOND: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia
 
 
Lisainfo
Keemiakandidaat Bioloogiadoktor
1971 Moskva Ülikoolis
1981Moskva Kardiokeskus

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2015
Guzun, Rita; Kaambre, Tuuli; Bagur, Rafaela; Grichine, Alexei; Usson, Yves; Varikmaa, Minna; Anmann, Tiia; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Boucher, Francois; Dos Santos, Pierre; Schlattner, Uwe; Wallimann, Theo; Kuznetsov, Andrey; Dzeja, Petras; Aliev, Mayis; Saks, Valdur (2015). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica, 213 (1), 84−106.10.1111/apha.12287.
1.1.
2014
Anmann, Tiia; Varikmaa, Minna; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor, Chekulayev, Vladimir'; Saks, Valdur; Kaambre, Tuuli. (2014). Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochimica et Biophysica Acta - Bioenergetics, 1837 (8), 1350−1361.10.1016/j.bbabio.2014.03.015.
1.1.
2014
Varikmaa, M.; Bagur, R.; Kaambre, T.; Grichine, A.; Timohhina, N.; Tepp, K.; Shevchuk, I.; Chekulayev, V.; Metsis, M.; Boucher, F.; Saks, V.; Kuznetsov, A. V.; Guzun, R. (2014). Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochimica et Biophysica Acta - Bioenergetics, 1837 (2), 232−245.10.1016/j.bbabio.2013.10.011.
1.1.
2014
Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Shevchuk, Igor; Tepp, Kersti; Kaldma, Andrus; Koit, Andre; Saks, Valdur; Kaambre, Tuuli (2014). Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. Journal of Bioenergetics and Biomembranes, 46 (1), 17−31.10.1007/s10863-013-9529-5.
3.1.
2014
Saks, V.; Schlattner, U.;Tokarska-Schlattner, M.; Wallimann, T.; Bagur, R.; Zorman, S.; Pelosse, M.; Dos Santos, P.; Boucher, F; Kaambre, T.; Guzun, R. (2014). Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine,Phosphotransfer Pathways, and AMPK Signaling. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (Ed.). " SYSTEMS BIOLOGY OF METABOLIC AND SIGNALING NETWORKS: ENERGY, MASS AND INFORMATION TRANSFER." (261−320).. Heidelberg: Springer-Verlag Berlin. (Springer Series in Biophysics; 16).10.1007/978-3-642-38505-6_11.
3.1.
2014
Aon, M. A.; Lloyd, D.; Saks, V. (2014). From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (_EditorsAbbr). Systems Biology of Metabolic and Signaling Networks (3−17).. Springer-Verlag Heidelberg.10.1007/978-3-642-38505-6_1.
1.1.
2013
Kaambre, Tuuli; Chekulayev, Vladimir; Shevchuk, Igor; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Bagur, Rafaela; Klepinin, Aleksandr; Anmann, Tiia; Koit, Andre; Kaldma, Andrus; Guzun, Rita; Valvere, Vahur; Saks, Valdur (2013). Metabolic Control Analysis of Respiration in Human Cancer Tissue. Frontiers in Physiology, 4, 1−6.10.3389/fphys.2013.00151.
1.1.
2013
Varikmaa, M.; Guzun, R.; Grichine, A.; Gonzalez-Granillo, M;, Usson, Y.: Boucher, F.; Kaambre, T.; Saks, V. (2013). Matters of the heart in bioenergetics: mitochondrial fusion into continuous reticulum is not needed for maximal respiratory activity. Journal of Bioenergetics and Biomembranes, 45 (4), 319−331.10.1007/s10863-012-9494-4.
1.3.
2013
Käämbre, Tuuli; Koit, Andre; Ševtšuk, Igor; Tšekulajev, Vladimir; Tepp, Kersti; Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur (2013). Uusi suundi kasvajate energiametabolismi uuringutes. Eesti Arst, 92 (5), 261−267.
1.3.
2013
Anmann, Tiia; Varikmaa, Minna; Tepp, Kersti; Timohhina, Natalja; Ševtšuk, Igor; Tšekulajev, Vladimir; Saks, Valdur; Käämbre, Tuuli (2013). Südamerakkude sünnijärgse arengu bioenergeetilised aspektid: struktuuri ja funktsiooni vaheliste seoste väljakujunemine. Eesti Arst, 92 (7), 372−381.
3.5.
2013
Käämbre, T., Ševtšuk, I., Saks, V. (2013). Süsteemibioloogia ja süsteemibioenergeetika: kuidas uurida struktuuri ja funktsiooni vahelisi seoseid. Teoreetilise bioloogia kevadkool: 39. Teoreetilise bioloogia kevadkool, Mustjõe, Aegviidu. Toim. Sõber, Virve; Laanisto, Lauri; Öpik, Maarja; Tammaru, Toomas; Kull, Kalevi. Tartu: Eesti Looduseuurijate Selts, 29−40. (Schola Biotheoretica; 39).
3.5.
2013
Varikmaa, M; Bagur, R; Metsis, M; Grichine, A; Tepp, K; Käämbre, T; Saks, V and Guzun, R. (2013). Fine-tuning mitochondria function by betaII tubulin in striated muscles. Barcelona BioMed Conference "The microtubule cytoskeleton in development and disease"..
5.1.
2013
Quetglas, RB; Karu-Varikmaa, M; Tepp, K; Metsis, M; Kaambre, T; Grichine, A; Boucher, F; Saks, V; Guzun, R (2013). Regulation of Respiration in Permeabilized Muscle Cells: Apparent KM for ADP Shows the Mitochondrial Outer Membrane Permeability. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. 447A−448A. (2; 1).
5.1.
2013
Karu, M ; Bagun, R ; Metsis, M ; Grichine, A; Tepp, K ; Kaambre, T; Saks, V; Guzun, R (2013). Unpolymerized beta II Tubulin in Regulation of Mitocondrial Function in Muscle Cells. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. 302A−302A. (2; 1).
5.1.
2013
Koit, Andre; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Bogovskaja, Jelena; Valvere, Vahur Saks, Valdur; Kaambre, Tuuli (2013). Bioenergetic profiling of human breast cancer: unusual organisation of the respiratory chain. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 922.10.1016/j.mito.2013.07.064.
5.1.
2013
Kaldma, Andrus; Koit, Andre; Shevchuk, Igor; Chekulayev, Vladimir; Tepp, Kersti; Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur; Kaambre, Tuuli (2013). Regulation of respiration of human colorectal cancer: application of Metabolic Control Analysis. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 900.
5.1.
2013
Shevchuk, Igor; Koit, Andre; Kaldma, Andrus; Timohhina, Natalja; Chekulayev, Vladimir; Tepp, Kersti; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur; Kaambre, Tuuli (2013). Comparative aspects of bioenergetic profiling of tumor clinical material and cell cultures. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 907.10.1016/j.mito.2013.07.027.
1.1.
2012
Guzun, R.; Aguilaniu, B.; Wuyam, B.; Mezin, P.; Koechlin-Ramonatxo, C.; Auffray, C.; Saks, V.; Pison, C. (2012). Effects of training at mild exercise intensities on quadriceps muscle energy metabolism in patients with chronic obstructive pulmonary disease. Acta Physiologica, 205 (2), 236−246.10.1111/j.1748-1716.2011.02388.x.
1.1.
2012
Tokarska-Schlattner, M., Epand, R.F., Meiler, F et al.. (2012). Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects. PLoS ONE, 7, e43178.
1.1.
2012
Kuznetsov, A.V.; Guzun, R.; Boucher, F.; Bagur, R.; Käämbre, T.; Saks, V. (2012). Mysterious Ca2+-independent muscular contraction: deja vu. Biochemical Journal, 445, 333−336.DOI:BJ20120439[pii]10.1042/BJ20120439.
1.1.
2012
Käämbre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Tepp, K.; Bogovskaja, J.; Kütner, R.; Valvere, V.; Saks, V. (2012). Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. Journal of Bioenergetics and Biomembranes, 44 (5), 539−558.DOI:10.1007/s10863-012-9457-9.
1.1.
2012
Guzun, R.; Gonzalez-Granillo, M.; Karu-Varikmaa, M.; Grichine, A.; Usson, Y.; Käämbre, T.; Guerrero-Roesch, K.; Kuznetsov, A.; Schlattner, U.; Saks, V. (2012). Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1818, 1545−1554.DOI:10.1016/j.bbamem.2011.12.034.
1.1.
2012
Gonzalez-Granillo, M.; Grichine, A.; Guzun, R.; Ussov, Y.; Tepp, K.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Kuznetsov, A.V.; Grimm, M.; Saks, V.; Käämbre, T. (2012). Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. Journal of Molecular and Cellular Cardiology, 52, 437−447.DOI:10.1016/j.yjmcc.2011.07.027.
1.1.
2012
Saks, V.; Kuznetsov, A.V.; Gonzalez-Granillo, M.; Tepp, K.; Timohhina, N.; Karu-Varikmaa, M.; Käämbre, T.; Santos, P.D.; Boucher, F.; Guzun, R. (2012). Intracellular energetic Units regulate metabolism in cardiac cells. Journal of Molecular and Cellular Cardiology, 419−436.DOI:10.1016/j.yjmcc.2011.07.015.
5.1.
2012
Tepp, K.; Kaambre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Valvere, V.; Saks, V. (2012). Comparative investigation of bioenergetic properties of human colorectal and breast cancer. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S136. (supplement to volume 1817).
5.1.
2012
Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Tepp, K.; Klepinin, A.; Saks, V.; Kaambre, T. (2012). Metabolic control analysis of integrated energy metabolism in permeabilized neuroblastoma cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S135. (supplement for volume 1817).
5.2.
2012
Timohhina, N.; Anmann, T.; Klepinin, A.; Tepp, K.; Shevchuk, I.; Käämbre, T.; Saks, V. (2012). Postnatal developments of rat heart: formation of intracellular energetic units. In New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. June 12-15, 2012; Hradec Kralove, Czech Republic, Hradec Kralove. 40−40.
5.2.
2012
Tepp, K.; Timohhina, N.; Chekulayev, V.; Saks, V.; Kaambre, T.; Shevchuk, I. (2012). Control Analysis of Intracellular Energetic Unit in cardiac cell. In New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. June 12-15, 2012; Hradec Kralove, Czech Republic, Hradec Kralove. 39−39.
5.2.
2012
Klepinin, A.; Karu-Varikmaa, M.; Shevchuk, I.; Chekulayev, V.; Tepp, K.; Saks, V. and Käämbre, T. (2012). Intracellular energetic units organized by tubulin. New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. Hradec Kralove, Czech Republic, Hradec Kralove, June 12-15, 2012. 39-40−40.
1.1.
2011
Aliev, M., Guzun, R., Karu-Varikmaa, M., Kaambre, T., Wallimann, T., Saks, V. (2011). Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modeling. International Journal of Molecular Sciences, 12 (12), 9296−9331.10.3390/ijms12129296.
1.1.
2011
Kuznetsov, A.V.; Margreiter, R.; Amberger, A.; Saks, V.; Grimm, M. (2011). Changes in mitochondrial dysfunction in doxorubicin-induced cell death. Biochimica et Biophysica Acta, 1813 (6), 1144−1152.
1.1.
2011
Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Kuznetsov, A.V.; Guzun, R.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochimica et Biophysica Acta, 1807 (12), 1549−1561.
1.1.
2011
Guzun, R.; Timohhina, N.; Tepp, K.; Gonzalez-Granillo, M.; Shevchuk, I.; Chekulayev, V.; Kuznetsov, A.V.; Käämbre, T.; Saks, V.A. (2011). Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function. Amino Acids, 40, 1333−1348.
1.1.
2011
Guzun, R.; Karu-Varikmaa, M.; Granillo, M.G.; Kuznetsov, A.V.; Michel, L.; Cottet-Rousselle, C.; Saaremäe, M.; Käämbre, T.; Metsis, M.; Grimm, M.; Auffray, C.; Saks, V. (2011). Mitochondria-cytoskeleton interaction: Distribution of β-tubulins in cardiomyocytes and HL-1 cells. Biochimica et Biophysica Acta, 1807 (4), 458−469.
5.1.
2011
Karu-Varikmaa, M.; Metsis, M.; Guzun, R.; Käämbre, T.; Grichine, A.; Saks, V. (2011). Investigation of interactions between mitochondrial creatine kinase and ATP/ADP channel. FEBS Journal, 278, 374−375.
5.1.
2011
Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux control with mitochondrial interactosome in cardiac cell. FEBS Journal, 278, 377−377.
5.1.
2011
Saks, V.; Aliev, M.; Tepp, K.; Karu-Varikmaa, M.; Chekulaev, V.; Shevchuk, I.; Käämbre, T.; Guzun, R. (2011). Quantitative Analysis of Integrated Energy Metabolism of Muscle Cells: Experimental and Theoretical Studies. Biophysical Journal, 100, 2a−2a.
5.2.
2011
Gonzalez-Granillo, M.A.; Karu-Varikmaa, M.; Saaremäe, M.; Michel, L.; Käämbre, T.; Saks, V.; Guzun, R. (2011). Mitochondrial Interactosome in Energy Metabolism in Healthy and Cancer Cells. Biophysical Journal, 100, 298a−298a.
5.2.
2011
Karu-Varikmaa, M.; Saaremäe, M.; Sikk, P.; Käämbre, T.; Metsis, M.; Saks, V. (2011). Regulation of Mitochondrial Respiration by Different Tubulin Isoforms in Vivo. Biophysical Journal, 100, 459a−459a.
1.1.
2010
Tepp, Kersti; Timohhina, Natalya; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes - experimental study. Acta Biochimica Polonica, 57 (4), 421−430.
1.1.
2010
Guzun, R.; Saks, V. (2010). Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo. International Journal of Molecular Sciences, 11, 982−1019.
1.1.
2010
Tokarska-Schlattner, M.; Lucchinetti, E.; Zaugg, M.; Kay, L.; Gratia, S.; Guzun, R.; Saks, VA.; Schlattner, U. (2010). Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 298 (4), R1075−R1088.10.1152/ajpregu.00360.2009.
1.1.
2010
Saks, Valdur; Guzun, Rita; Timohhina, Natalja; Tepp, Kersti; Varikmaa, Minna; Monge, Claire; Beraud, Nathalie; Käämbre, Tuuli; Kuznetsov, Andrey; Kadaja, Lumme; Eimre, Margus; Seppet, Enn. (2010). Structure–function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1797, 678−697.
1.1.
2010
Guerrero, K.; Monge, C.; Brückner, A.; Puurand, U.; Kadaja, L.; Käämbre, T.; Seppet, E.; Saks, V. (2010). Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Molecular and Cellular Biochemistry, 337, 239−249.10.1007/s11010-009-0304-1.
3.1.
2010
Monge, Claire; Guzun, Rita; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Sikk, Peeter; Käämbre, Tuuli; Saks, Valdur (2010). Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells. In: Oliver L. Svensson (Ed.). Mitochondria: Structure, Functions and Dysfunctions (441−470).. Nova Science Publisher Inc..
5.1.
2010
Varikmaa, Minna; Metsis, Madis; Guzun, Rita; Käämbre, Tuuli; Grichine, Alexei; Saks, Valdur (2010). Novel Method for Investigation of Interactions between Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase. Biophysical Journal, 98: Biophysical Society 54th Annual Meeting, February 20-24 , San Fransisco. 2010, 735a. (3).
5.1.
2010
Saks, V.; Guzun, R.; Timohhina, N.; Tepp, K.; Varikmaa, M.; Monge, C.; Beraud, N.; Kaambre, T.; Kuznetsov, A.; Kadaja, L.; Margus, E.; Seppet, E. (2010). Systems biology and bioenergetics: Structure-function relationships in feedback regulation of energy fluxes in vivo Mitochondrial interactosome. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−138. (Supplement 1).
5.1.
2010
Tepp, Kersti; Timohhina, Natalja; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−139. (Supplement 1).
1.1.
2009
Saks, V. (2009). Molecular System Bioenergetics-New Aspects of Metabolic Research. International Journal of Molecular Sciences, 10 (8), 3655−3657.
1.1.
2009
Kuznetsov, A.V.; Hermann, M.; Saks, V.; Hengster, P.; Margreiter, R. (2009). The cell-type specificity of mitochondrial dynamics. International Journal of Biochemistry & Cell Biology, 41 (10), 1928−1939.
1.1.
2009
Beraud, Nathalie; Pelloux, Sophie; Usson, Yves; Kuznetsov, Andrey V.; Ronot, Xavier; Tourneur, Yves; Saks, Valdur (2009). Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells. Journal of Bioenergetics and Biomembranes, 41 (2), 195−214.10.1007/s10863-009-9214-x.
1.1.
2009
Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.
1.1.
2009
Guzun, R.; Timohhina, N.; Tepp, K.; Monge, C.; Käämbre, T.; Sikk, P.; Kuznetsov, AV.; Pison, C.; Saks, V. (2009). Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ importance of system level properties. Biochimica et Biophysica Acta - Bioenergetics, 1787 (9), 1089−1105.10.1016/j.bbabio.2009.03.024.
1.1.
2009
Monge, Claire; Beraud, Nathalie; Tepp, Kersti; Pelloux, Sophie; Chahboun, Siham; Käämbre, Tuuli; Kadaja, Lumme; Roosimaa, Mart; Piirsoo, Andres; Tourneur, Yves; Kuznetsov, Andrey V; Saks, Valdur; Seppet, Enn (2009). Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Canadian Journal of Physiology and Pharmacology, 87 (4), 318−326.
1.1.
2009
Saks, Valdur; Monge, Claire; Guzun, Rita (2009). Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research. International Journal of Molecular Sciences, 10, 1161−1192.
1.1.
2009
Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu; Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.
5.2.
2009
Beraud, Nathalie; Pelloux, Sophie; Usson, Yves; Kuznetsov, Andrey V.; Ronot, Xavier; Tourneur, Yves; Saks, Valdur (2009). Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non-beating Hl-1 cells. Biophysical Journal, 96, 243a.10.1016/j.bpj.2008.12.1197.
6.7.
2009
Saks, Valdur; Engelbrecht, Jüri; Seppet, Enn; Vendelin, Marko (2009). Molekulaarne süsteemne bioenergeetika : kommentaar Eesti Vabariigi teaduse aastapreemia pälvinud tööde tsüklile. Mägi, Vahur (_EditorsAbbr). Tallinna Tehnikaülikooli aastaraamat 2008. XVI (291−298).. Tallinn: TTÜ kirjastus.
1.1.
2008
Rostovtseva, Tatiana K.; Sheldon, Kely L.; Hassanzadeh, Elnaz; Monge, Claire; Saks, Valdur; Bezrukov, Sergey M.; Sackett, Dan L. (2008). Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proceedings of the National Academy of Sciences of the United States of America, 105 (48), 18746−18751.
1.1.
2008
Kuznetsov, A.V.; Veksler, V.; Gellerich, F.N.; Saks, V.; Margreiter, R.; Kunz, W.S. (2008). Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nature Protocols, 3 (6), 965−976.
1.1.
2008
Saks, V. (2008). The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and alive. Journal of Physiology-London, 586 (12), 2817−2818.
1.1.
2008
Monge, C.; Beraud, N.; Kuznetsov, A.V.; Rostovtseva, T.; Sackett, D.; Schlattner, U.; Vendelin, M.; Saks, V.A. (2008). Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion insitu, roles of tubulin, and mitochondrial creatine kinase. Molecular and Cellular Biochemistry, 318, 147−165.10.1007/s11010-008-9865-7.
1.1.
2008
Saks, V.; Beraud, N.; Wallimann, T. (2008). Metabolic compartmentation - A system level property of muscle cells. International Journal of Molecular Sciences, 9 (5), 751−767.
1.1.
2008
Eimre, M.; Paju, K.; Pelloux, S.; Beraud, N.; Roosimaa, M.; Kadaja, L.; Gruno, M.; Peet, N.; Orlova, E.; Remmelkoor, R.; Piirsoo, A.; Saks, V.; Seppet, E. (2008). Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochimica et Biophysica Acta - Bioenergetics, 1777 (6), 514−524.
1.3.
2008
Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Tiivel, Toomas; Timohhina, Natalja; Nutt, Anu; Tepp, Kersti; Saks, Valdur (2008). Südamelihase rakkude struktuuri olulisusest rakuhingamise regulatsioonis. Eesti Arst, 1, 19−22.
5.1.
2008
Seppet, E.; Paju, K.; Roosimaa, M.; Kadaja, L.; Peet, N.; Eimre, M.; Orlova, E.; Saks, V. (2008). Distinct organization of energy metabolism in HL-1 cardiac cells and cardiomyocytes. Journal of Molecular and Cellular Cardiology, 44 (4), 780−781.10.1016/j.yjmcc.2008.02.166.
5.2.
2008
Guzun, Rita; Timokhina, Nathalia; Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Saks, Valdur (2008). DIFFERENT STEADY STATE KINETICS OF REGULATION OF MtCK – DEPENDENT RESPIRATION IN ISOLATED MITOCHONDRIA AND PERMEABILIZED CARDIAC CELL in situ. Biophysical Society 52nd Annual Meeting & 16th International Biophysics Congress February 2-6, 2008 Long Beach, California.
5.2.
2008
Seppet, Enn; Saks, Valdur (2008). Structure-function relationships in organization of energy metabolism in cardiac cells. Experimental and Clinical Cardiology, 13: Mendel Symposium II: genes and the Heart, Joint Meeting of the japan and European sections of the International Academy of cardiovascular Sciences; Leblice, Czech Republic; September 24 to 27. _EditorsAbbr Ostadal, B. Canada: Pulsus Group Inc, 151−151.
5.2.
2008
Seppet, E.; Paju, K.; Roosimaa, M.; Kadaja, L.; Peet, N.; Eimre, M.; Orlova, E.; Saks, V. (2008). Distinct organization of energy metabolism in different types of cardiac cells. NATO Advanced Research Workshop on Translational Knowledge for Heart Research; Istanbul, Turkey; 12-16 May 2008.
6.7.
2008
[Saks, Valdur; Engelbrecht, Jüri; Seppet, Enn; Vendelin, Marko] (2008). Teaduspreemia geo-ja bioteaduste alal tööde tsükli "Molekulaarne süsteemne bioenergeetia" eest. Villems,Richard (_EditorsAbbr). Eesti Vabariigi teaduspreemiad 2008 (110−123).. Tallinn: Eesti Teaduste Akadeemia.
3.1.
2007
Saks, V. (2007). From the discovery of oxygen to molecular system bioenergetics. In: V.Saks (_EditorsAbbr). MOLECULAR SYSTEM BIOENERGETICS./ ENERGY FOR LIFE (x).. Manheim: Wiley-VCH.
3.1.
2007
Saks, Valdur; Dzeja, Petras P.; Guzun, Rita; Aliev, Mayis K.; Vendelin, Marko; Terzic, André; Wallimann, Theo (2007). System analysis of cardiac energetics - excitation-contraction coupling: integration of mitochondrial respiration, phosphotransfer pathways, metabolic pacing and substrate supply in the heart. In: Saks, Valdur (_EditorsAbbr). Molecular system bioenergetics: energy for life (367−406).. Weinheim: Wiley-VCH.10.1002/9783527621095.ch11.
3.1.
2007
Saks, V.; Monge, C.; Anmann, T.; Dzeja, P. (2007). Integrated and organized cellular energetic systems: theories of cell energetics, compartmentation and metabolic channeling. In: V.Saks (_EditorsAbbr). MOLECULAR SYSTEM BIOENERGETICS./ ENERGY FOR LIFE (59−97).. Manheim: Wiley-VCH.
3.1.
2007
Saks, V.; Kaambre, T.; Guzun, R.; Anmann, T.; Sikk, P.; Schlattner, U.; Wallimann, T.; Aliev, M.; Vendelin, M. (2007). The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches. In: Salomons, G.S.; Wyss, M. (Ed.). Creatine and Creatine Kinase in Health and Disease (27−65).. Dordrecht: Springer. (Subcellular Biochemistry; 46).10.1007/978-1-4020-6486-9_3.
3.1.
2007
Vendelin, Marko; Saks, Valdur; Engelbrecht, Jüri (2007). Principles of mathematical modeling and in silico studies of integrated cellular energetics. In: Saks,Valdur (_EditorsAbbr). Molecular system bioenergetics: energy for life (407−433).. Weinheim: Wiley-VCH.10.1002/9783527621095.ch12.
3.1.
2007
Saks, V.A.; Vendelin, M.; Aliev, M.K.; Kekelidze, T.; Engelbrecht, J. (2007). Mechanisms and modeling of energy transfer between intracellular compartments. In: Lajtha, A.; Gibson, G. E.; Dienel, G. A. (_EditorsAbbr). Handbook of Neurochemistry and Molecular Neurobiology : Brain Energetics. Integration of Molecular and Cellular Processes (815−860).. New York: Springer. (8.1).10.1007/978-0-387-30411-3_30.
4.1.
2007
Saks, Valdur (Editor) (2007). Molecular System Bioenergetics: Energy for Life. Manheim: Wiley-VCH.
5.1.
2007
Saks, V.A.; Vendelin, M.; Aliev, M.; Monge, C.; Engelbrecht, J. (2007). Molecular system bioenergetics: Mechanisms and modelling of energy transfer between intracellular compartments. Journal of Neurochemistry, 102, 16.
5.1.
2007
Vendelin, M.; Anmann, T.; Kaambre, T.; Sikk, P.; Saks, V. (2007). Modeling of the coupled enzyme systems: model of mitochondrial creatine kinase (miCK) and adenine nucleotide translocase (ANT) coupling. Biophysical Journal, Suppl S, 660A.
5.1.
2007
Anmann, T., Monge, C., Bemud, N., Pelloux, S., Toumeur, Y., Saks, V. (2007). Coupled creatine kinase systems in cardiac cells and synaptosomes: a comparative kinetic study. Biophysical Society Meeting Abstracts: 51st Annual Meeting of the Biophysical-Society, Baltimore, MD, MAR 03-07, 2007. BioPhysical Society, 621A. (Biophysical Journal Supplement).
1.1.
2006
Anmann, T.; Guzun, R.; Beraud, N.; Pelloux, S.; Kuznetsov, A.V.; Kogerman, L.; Kaambre, T.; Sikk, P.; Paju, K.; Peet, N.; Seppet, E.; Ojeda, C.; Tourneur, Y.; Saks, V. (2006). Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells - Importance of cell structure/organization for respiration regulation. Biochimica et Biophysica Acta - Bioenergetics, 1757 (12), 1597−1606 .10.1016/j.bbabio.2006.09.008.
1.1.
2006
Saks, Valdur; Dzeja, Petras; Schlattner, Uwe; Vendelin, Marko; Terzic, Andre; Wallimann, Theo (2006). Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. The Journal of Physiology, 571 (2), 253−273.
1.1.
2006
Eimre, M.; Puhke, R.; Alev, K.; Seppet, E.; Sikkut, A.; Peet, N.; Kadaja, L.; Lenzner, A.; Haviko, T.; Seene, T.; Saks, V.A.; Seppet, E.K. (2006). Altered mitochondrial apparent affinity for ADP and impaired function of mitochondrial creatine kinase in gluteus medius of patients with hip osteoarthritis. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 290 (5), R1271−R1275.
1.1.
2006
Pelloux, S.; Robillard, J.; Ferrera, R.; Bilbaut, A.; Ojeda, C.; Saks, V.; Ovize, M.; Tourneur, Y. (2006). Non beating HL-1 cells for confocal microscopy. Application to mitochondrial functions during cardiac preconditioning. Progress in Biophysics and Molecular Biology, 90, 270−298.
1.2.
2006
Seppet, E.K.; Eimre, M.; Anmann, T.; Seppet, E.; Piirsoo, A.; Peet, N.; Paju, K.; Guzun, R.; Beraud, N.; Pelloux, S.; Tourneur, Y.; Kuznetsov, A.V.; Käämbre, T.; Sikk, P.; Saks, V.A. (2006). Structure-function relationships in regulation of the energy transfer between mitochondria and ATPases in cardiac cells. Experimental and Clinical Cardiology, 11 (3), 189−194.
3.1.
2006
Saks, V.; Guerrero, K.; Vendelin, M.; Engelbrecht, J.; Seppet, E. (2006). The creatine kinase isoenzymes in organized metabolic networks and regulation of cellular respiration: a new role for Maxwell's demon. In: Vial, C. (_EditorsAbbr). Creatine Kinase (223−267).. New York: Nova Science Publishers. (Molecular Anatomy and Physiology of Proteins).
3.2.
2006
Saks, V.; Aliev, M.; Guzun, R.; Beraud, N.; Monge, C.; Anmann, T.; Kuznetsov, A.; Seppet, E. (2006). Biophysics of the organized metabolic networks in muscle and brain cells. In: Pandalai, S.G. (_EditorsAbbr). Recent Research Developments in Biophysics (269−318).. Kerala, India: Transworld Research Networks.
5.1.
2006
Seppet, E.K.; Eimre, M.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Kaambre, T.; Saks, VA. (2006). Calcium-induced contraction of sarcomeres changes the interaction between mitochondria and ATPases in permeabilized cardiac cells. Journal of Molecular and Cellular Cardiology, 40 (6), 931−931.
5.1.
2006
Beraud, N.; Pelloux, S.; Kuznetsov, A.; Guzun, R.; Anmann, T.; Tourneur, Y.; Ojeda, C.; Saks, V. (2006). Comparative bioeneregetics of isolated cardiomyocytes and HL-1 cells: Mitochondrial dynamics, respiration regulation and creatine kinase expression. 514−515.
5.2.
2006
Eimre, M.; Seppet, E.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Käämbre, T.; Saks, V. (2006). Kaltsiumist põhjustatud sarkomeeride kontraktsioon muudab mitokondrite ja ATPaaside vahelist interaktsiooni permeabiliseeritud südamerakkudes. 85. 645−646.
1.1.
2005
Guerrero, Karen; Wuyam, Bernard; Mezin, Paulette; Vivodtzev, Isabelle; Vendelin, Marko; Borel, Jean Christian; Hacini, Rachid; Chavanon, Olivier; Imbeaud, Sandrine; Saks, Valdur; Pison, Christophe (2005). Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 289 (4), R1144−R1154.
1.1.
2005
Vendelin, Marko; Beraud, Nathalie; Guerrero, Karen; Andrienko, Tatiana; Kuznetsov, Andrey V.; Olivares, Jose; Kay, Laurence; Saks, Valdur A. (2005). Mitochondrial regular arrangement in muscle cells: a "crystal-like" pattern. American Journal of Physiology - Cell Physiology, 288 (3), C757−C767.
1.1.
2005
Saks, V.A.; Wallimann, T.; Schlattner, U. (2005). Calcium and energy transfer. Journal of Physiology-London, 565 (2), 703−703.
1.1.
2005
Peltier, S.; Burelle, Y.; Novel-Chate, V.; Demaison, L.; Verdys, M.; Saks, V.; Keriel, C.; Leverve, XM. (2005). Effect of exogenous adenosine and monensin on glycolytic flux in isolated perfused normoxic rat hearts: Role of pyruvate kinase. Molecular and Cellular Biochemistry, 277, 55−61.
1.1.
2005
Anmann, T.; Eimre, M.; Kuznetsov, AV.; Andrienko, T.; Kaambre, T.; Sikk, P.; Seppet, E.; Tiivel, T.; Vendelin, M.; Seppet, E.; Saks, VA. (2005). Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal, 272 (12), 3145−3161.10.1111/j.1742-4658.2005.04734.x.
1.1.
2005
Seppet, E.; Eimre, M.; Peet, N.; Paju, K.; Orlova, E.; Ress, M.; Kovask, S.; Piirsoo, A.; Saks, VA.; Gellerich, FN.; Zierz, S.; Seppet, EK. (2005). Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Molecular and Cellular Biochemistry, 270, 49−61.
1.1.
2005
Seppet, E. K.; Eimre, M.; Anmann, T.; Seppet, E.; Peet, N.; Käämbre, T.; Paju, K.; Piirsoo, A.; Kuznetsov, A. V.; Vendelin, M.; Gellerich, F. N.; Zierz, S.; Saks, V. A. (2005). Intracellular energetic units in healthy and diseased hearts. Experimental and Clinical Cardiology, 10 (3), 173−183.
5.1.
2005
Kuznetsov, AV.; Kaambre, T.; Sikk, P.; Saks, V. (2005). Ca2+ and regulation of mitochondrial respiration: Functional and confocal imaging studies. 23, Suppl 2. 8−8.
1.1.
2004
Saks, V.; Kuznetsov, A.V.; Vendelin, M.; Guerrero, K.; Kay, L.; Seppet, E.K. (2004). Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism. Molecular and Cellular Biochemistry, 256/257, 185−199.10.1023/B:MCBI.0000009868.92189.fb.
1.1.
2004
Vendelin, Marko; Eimre, Margus; Seppet, Evelin; Peet, Nadezda; Andrienko, Tatiana; Lemba, Maris; Engelbrecht, Jüri; Seppet, Enn K.; Saks, Valdur A. (2004). Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscle. Molecular and Cellular Biochemistry, 256, 229−241.10.1023/B:MCBI.0000009871.04141.64.
1.1.
2004
Vendelin, Marko; Lemba, Maris; Saks, Valdur A. (2004). Analysis of functional coupling: Mitochondrial creatine kinase and adenine nucleotide translocase. Biophysical Journal, 87 (1), 696−713.
1.1.
2004
Ovadi, J.; Saks, V. (2004). On the origin of intracellular compartmentation and organized metabolic systems. Molecular and Cellular Biochemistry, 5−12.
1.1.
2004
Ojeda, C.; Joseph, P.; Saks, V. A.; Piriou, V.; Tourneur, Y. (2004). Subcellular heterogeneity in mitochondrial red-ox responses to KATP channel agonists in freshly isolated rabbit cardiomyocytes. Molecular and Cellular Biochemistry, 367−377.
1.1.
2004
Kuznetsov, A. V.; Schneeberger, S.; Seiler, R.; Brandacher, G.; Mark, W.; Steurer, W.; Saks, V.; Usson, Y.; Margreiter, R.; Gnaiger, E. (2004). Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. American Journal of Physiology - Heart and Circulatory Physiology, 286 (5), H1633−H1641.
1.1.
2004
Kuznetsov, A. V.; Schneeberger, S.; Renz, O.; Meusburger, H.; Saks, V.; Usson, Y.; Margreiter, R. (2004). Functional heterogeneity of mitochondria after cardiac cold ischemia and reperfusion revealed by confocal imaging. Transplantation, 77, 754−756.
1.1.
2004
Kulp, M.; Kaljurand, M.; Kaambre, T.; Sikk, P.; Saks, V (2004). In situ monitoring of kinetics of metabolic conversion of ATP to ADP catalyzed by mgatpases of muscle Gastrocnemius skinned fibers using micellar electrokinetic chromatography. Electrophoresis, 25 (17), 2996−3002.
1.1.
2004
Seppet, EK.; Eimre, M.; Andrienko, T.; Kaambre, T.; Sikk, P.; Kuznetsov, AV.; Saks, V. (2004). Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modelling. Molecular and Cellular Biochemistry, 256, 219−227.
5.1.
2004
Vendelin, Marko; Lemba, Maris; Saks, Valdur A. (2004). Analysis of functional coupling: Mitochondrial creatine kinase and adenine nucleotide translocase. Biochimica et Biophysica Acta - Bioenergetics, 1658, 198.
5.1.
2004
Vendelin, M.; Guerrero, K.; Andrienko, T.; Saks, V. (2004). Intracellular restrictions of diffusion and metabolic channeling of ADP in cardiac muscle cells. Biophysical Journal, 86 (1), 336A, Part 2 Suppl. S, JAN 2004.
5.1.
2004
Saks, V.; Andrienko, T.; Kuznetsov, A.; Zorov, D; Käämbre, T.; Sikk, P. (2004). Ca2+ contraction and mitochondria in heart: A mechanochemical link? 86. 336A−337A.
5.1.
2004
Seppet, E.; Eimre, M.; Peet, N.; Paju, K.; Ress, M.; Kovask, S.; Saks, VA.; Gellerich, FN.; Zierz, S.; Seppet, EK. (2004). Intracellular energetic units in diseased human atrial myocardium. Journal of Molecular and Cellular Cardiology, 36 (5), 758−758.
1.1.
2003
Aliev, MK.; Saks, VA. (2003). Analysis of the mechanism of functioning of mitochondrial adenine nucleotide translocase using mathematical models. Biofizika, 48 (6), 1075−1085.
1.1.
2003
Vendelin, M.; Bovendeerd, P.H.M.; Saks, V.; Engelbrecht, J.; Arts, T. (2003). Simulating cardiac mechanoenergetics in the left ventricle. Functional Imaging and Modeling of The Heart, Proceedings. 72−80. (Lecture Notes in Computer Science).
1.1.
2003
Andrienko, T.; Kuznetsov, A.V.;Kaambre, T.; Usson, Y.; Orosco, A.; Appaix, F.; Tiivel, T.; Sikk, P.; Vendelin, M.; Margreiter, R.; Saks, V.A. (2003). Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. The Journal of Experimental Biology, 206 (12), 2059−2072.
1.1.
2003
Saks, Valdur; Kuznetsov, Andrey; Andrienko, Tatiana; Usson, Yves; Appaix, Florence; Guerrero, Karen; Kaambre, Tuuli; Sikk, Peeter; Lemba, Maris; Vendelin, Marko (2003). Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophysical Journal, 84 (5), 3436−3456.10.1016/S0006-3495(03)70065-4.
1.1.
2003
Kuznetsov, A.V.; Kunz, W. S.; Saks, V.; Usson, Y.; Mazat, J. P.; Letellier, T.; Gellerich, F. N.; Margreiter, R. (2003). Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibers. Analytical Biochemistry, 319 (2), 296−303.
1.1.
2003
Appaix, F.; Kuznetsov, A. V.; Usson, Y.; Kay, L.; Andrienko, T.; Olivares, J.; Kaambre, T.; Sikk, P.; Margreiter, R.; Saks, V. (2003). Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Experimental Physiology, 88, 175−190.10.1113/eph8802511.
3.1.
2003
Seppet, E.; Peet, N.; Paju, K.; Ress, M.; Saks, V.; Gellerich, FN; Chen, Y.; Trumbeckaite, S.; Prondzinsky, R; Silber, R.; Werdan, K; Zierz, S.; Seppet, E. (2003). Mitochondrial function in failing human myocardium in vivo: atrioventricular differences. In: Singal P.K.; Dixon, I.M.C.; Kirshenbaum, L.A.; Dhalla, N.S. (Ed.). Cardiac Remodeling and Failure (459−470).. Dodrecht: Kluwer Academic Publishers. (Progress in Experimental Cardiology; 5).
3.1.
2003
Saks, V.A.; Kay, L.; Appaix, F.; Andrienko, T.; Seppet, E. (2003). Creatine kinase and brain energy metabolism: Function and disease. In: Kekelidze, T.; Holtzman, D. (_EditorsAbbr). Creatine Kinase and Brain Energy Metabolism (3−25).. Amsterdam, The Netherlands: IOS Press. (NATO Science Series: Life and Behavioural Sciences; 342).
3.1.
2003
Saks, V.; Appaix, F.; Usson, Y.; Guerrero, K.; Olivares, J.; Seppet, E.; Aliev, M.; Margreiter, R.; Kuznetsov, A. (2003). Localized control of oxidative phosphorylation within intracellular energetic units in heart cells: A possible solution of some old problems. In: Dhalla, N.S.; Hryshko, L.; Kardami, E. (_EditorsAbbr). Signal Transduction and Cardiac Hypertrophy (265−284).. Boston, USA: Kluwer Academic Publishers.
1.1.
2002
Vendelin, M.; Bovendeerd, P.; Saks, V.; Engelbrecht, J. (2002). Cardiac mechanoenergetics in silico. Neuroendocrinology Letters, 23 (1), 13−20.
1.1.
2002
Boudina, S.; Laclau, M. N.; Tariosse, L.; Daret, D.; Gouverneur, G.; Bonoron-Adele, S.; Saks, V. A.; DosSantos, P. (2002). Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. American Journal of Physiology - Heart and Circulatory Physiology, 282 (3), H821−H831.
1.1.
2002
Aliev, M.K.; DosSantos, P.; Hoerter, J.A.; Soboll, S.; Tikhonov, A.N.; Saks, V.A. (2002). Water content and its intracellular distribution in intact and saline perfused rat hearts revisited. Cardiovascular Research, 53 (1), 48−58.
1.1.
2002
Appaix, F.; Guerrero, K.; Rampal, D.; Izikki, M.; Kaambre, T.; Sikk, P.; Brdiczka, D.; Riva-Lavieille, C.; Olivares, J.; Longuet, M.; Antonsson, B.; Saks, V. (2002). Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochimica et Biophysica Acta, 1556, 156−167.
5.1.
2002
Saks, V.; Kay, L.; Andrienko, T.; Vendelin, M. (2002). Local restrictions of ADP diffusion between intracellular energetic units in cardiomyocytes. Biophysical Journal, 82 (1), 2991.
1.1.
2001
Walsh, B.; Tonkonogi, M.; Soderlund, K.; Hultman, E.; Saks, V.; Sahlin, K. (2001). The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. Journal of Physiology-London, 537 (3), 971−978.
1.1.
2001
Riva, C.; Chevrier, C.; Pasqual, N.; Saks, V.; Rossi, A. (2001). Bcl-2/Bax protein expression in heart, slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions. Molecular and Cellular Biochemistry, 226, 9−16.
1.1.
2001
Laclau, M. N.; Boudina, S.; Thambo, J. B.; Tariosse, L.; Gouverneur, G.; Bonoron-Adele, S.; Saks, V.A.; Garlid, K. D.; DosSantos, P. (2001). Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. Journal of Molecular and Cellular Cardiology, 33 (5), 947−956.
1.1.
2001
Menin, L.; Panchichkina, M.; Keriel, C.; Olivares, J.; Braun, U.; Seppert, EK.; Saks, VA. (2001). Macrocompartmentation of total creatine in cardiomyocytes revisited. Molecular and Cellular Biochemistry, 220, 149−159.
1.1.
2001
Seppet, EK.; Kaambre, T.; Sikk, P.; Tiivel, T.; Vija, H.; Tonkonogi, M.; Sahlin, K.; Kay, L.; Appaix, F.; Braun, U.; Eimre, M.; Saks, VA. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta - Bioenergetics, 1504, 379−395.10.1016/S0005-2728(00)00269-3.
1.1.
2001
Saks, VA.; Kaambre, T.; Sikk, P.; Eimre, M.; Orlova, E.; Paju, K.; Piirsoo, A.; Appaix, F.; Kay, L.; Regitz-Zagrosek, V.; Fleck, E.; Seppet, E. (2001). Intracellular energetic units in red muscle cells. Biochemical Journal, 356, 643−657.
5.1.
2001
Saks, V.; Kay, L.; Sikk, P.; Kaambre, T.; Seppet, E.; Piirsoo, A. (2001). Intracellular energetic units in muscle cells? Biophysical Journal, 80 (1), 583A−583A.
1.1.
2000
Saks, V.A.; Kongas, O.; Vendelin, M.; Kay, L. (2000). Role of the creatine/phosphocreatine system in the regulation of mitochondrial respiration. Acta Physiologica Scandinavica, 168 (4), 635−641.10.1046/j.1365-201x.2000.00715.x.
1.1.
2000
Vendelin, M.; Kongas, O.; Saks, V. (2000). Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer. American Journal of Physiology - Cell Physiology, 278 (4), C747−C764.
1.1.
2000
Kay, L.; Nicolay, K.; Wieringa, B.; Saks, V.; Wallimann, T. (2000). Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ. Journal of Biological Chemistry, 275 (10), 6937−6944.
1.1.
2000
DosSantos, P.; Aliev, M. K.; Diolez, P.; Duclos, F.; Besse, P.; Bonoron-Adele, S.; Sikk, P.; Canioni, P.; Saks, V.A. (2000). Metabolic control of contractile performance in isolated perfused rat heart. Analysis of experimental data by reaction:diffusion mathematical model. Journal of Molecular and Cellular Cardiology, 32, 1703−1734.
1.1.
2000
Tiivel, T.; Kadaya, L.; Kuznetsov, A.; Kaambre, T.; Peet, N.; Sikk, P.; Braun, U.; Ventura-Clapier, R.; Saks, V.; Seppet, EK. (2000). Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry, 208, 119−128.
3.1.
2000
Saks, V.; Vendelin, M.; Kongas, O.; Kay, L. (2000). Creatine-phosphocreatine pathway in the intracellular networks of energy transfer and signal transduction in muscle cells. Creatine: from basic science to clinical application, 0928-9550. _EditorsAbbr Paoletti, R.; Poli, A.; Jackson, A.S. Dordrecht: Kluwer Academic Publishers, 1−9. (Medical science symposia series; 14).
5.1.
2000
Saks, VA.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Tonkonogi, M.; Seppet, E.; Sahlin, K. (2000). Metabolic channelling in cardiac cells: Dependence of kinetics of respiration regulation on source of ADP. Biophysical Journal, 78 (1), 197A−197A.
5.1.
2000
Kongas, O.; Vendelin, M.; Saks, V. (2000). In silico regulation of oxidative phosphorylation in muscle cells in health and disease. Biophysical Journal, 78 (1), 1159Pos.
1.1.
1999
Tonkonogi, M.; Walsh, B.; Tiivel, T.; Saks, V.; Sahlin, K. (1999). Mitochondrial function in human skeletal muscle is not impaired by high intensity exercise. Pflugers Archiv-European Journal of Physiology, 437 (4), 562−568.
1.2.
1999
Kongas, O.; Vendelin, M.; Saks, V. (1999). Modeling of intracellular compartmentalized energy and metabolic fluxes in the heart. Medical & Biological Engineering & Computing, 37, 27−32.
5.1.
1999
Saks, V.A.; Aliev, M.; Kongas, O.; Vendelin, M. (1999). The regulation of mitochondrial activity in muscle cells by cytosolic factors: Experimental and theoretical analyses. Biophysical Journal, 76 (1), A2, Part 2.
5.2.
1999
Kadaja, Lumme; Peet, Nadežda; Braun, U; Vibo, Riina; Metsküla, Kaja; Tiivel, Toomas; Käämbre, Tuuli; Sikk, P; Kuznetsov, A; Ventura-Clapier, R; Saks, Valdur; Seppet, Evelin (1999). Oksüdatiivse fosforüülimise postnataalne regulatsioon roti müokardis in situ. Arstiteaduskonna aastakonverents, 7. oktoober 1999 : teesid, 35−36.
1.1.
1998
Saks, V.A.; Veksler, V.I.; Kuznetsov, A.V.; Kay, L.; Sikk, P.; Tiivel, T.; Tranqui, L.; Olivares, J.; Winkler, K.; Wiedemann, F.; Kunz, W.S. (1998). Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo. Molecular and Cellular Biochemistry, 184, 81−100.
1.1.
1998
Saks, V.; Aliev, M.; DosSantos, P.; Vendelin, M.; Kongas, O. (1998). Mathematical model of energy transfer in hearts with inhibited or ablated creatine kinase system. Magnetic Resonance Materials in Biology, Physics, and Medicine, 6, 124−125.10.1016/S1352-8661(98)00037-4.
1.1.
1998
Voloschuk, S.G.; Belikova, Yu.O.; Klushnik, T.P.; Benivalensky, D.S.; Saks, V.A. (1998). Comparative study of the kinetics of respiration and protein content of skinned fibers from different muscle types. Biokhimiya, 63 (2), 190−193.
1.1.
1998
Saks, V.A..; VenturaClapier, R.; Leverve, X.; Rossi, A.; Rigoulet, M. (1998). What do we not know of cellular bioenergetics? – a general view on the state of the art. Molecular and Cellular Biochemistry, 184, 3−9.
1.1.
1998
Saks, V.A.; DosSantos, P.; Gellerich, F.N.; Diolez, P. (1998). Quantitative studies of enzyme - substrate compartmentation, functional coupling and metabolic channelling in muscle cells. Molecular and Cellular Biochemistry, 184, 291−307.
1.1.
1998
Aliev, M.K.; vanDorsten, F.A.; Nederhoff, M.G.; vanEchteld, C.J.A.; Veksler, V.; Nicolay, K.; Saks, V.A. (1998). Mathematical model of compartmentalized energy transfer: its use for analysis and interpretation of 31P - NMR studies of isolated heart of creatine kinase deficient mice. Molecular and Cellular Biochemistry, 184, 209−229.
1.1.
1998
Rossi, A.; Kay, L.; Saks, V.A. (1998). Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: a potential cause for altered energy transfer in cardiac muscle? Molecular and Cellular Biochemistry, 184, 401−408.
1.1.
1998
Khuchua, Z.AL.; Qin, W.; Boero, J.; Cheng, J.; Payne, M.; Saks, V.A.; Strauss, A.W. (1998). Octamer formation by cardiac sarcomeric mitochondrial creatine kinase is mediated by charged N – terminal residues. Journal of Biological Chemistry, 273 (36), 22990−22996.
1.1.
1998
Novel-Chaté, V.; Mateo, P.; Saks, V.A.; Hoerter, J.A.; Rossi, A. (1998). Chronic exposure to hypoxic environment alters the mechanism of energy transfer in myocardium. Journal of Molecular and Cellular Cardiology, 30 (7), 1295−1303.
1.2.
1998
Seppet, E. K.; Kadaya, L.; Peet, N.; Käämbre, T.; Sikk, P.; Saks, V. A. (1998). The 27.5 kD protein appears to control the oxidative phosphorylation in slow twitch muscle cells. Pathophysiology, 5, 121−121.
1.1.
1997
Anflous, K.; Saks, V.; Mateo, P.; Samson, F.; Veksler, V.; Ventura-Clapier, R. (1997). Mitochondrial creatine kinase isoform expression does not correlate with its mode of action. Biochemical Journal, 322, 73−78.
1.1.
1997
Aliev, M.K.; Saks, V.A. (1997). Compartmentalised energy transfer in cardiomyocytes. Use of mathematical modelling for analysis of in vivo regulation of respiration. Biophysical Journal, 73 (1), 428−445.
1.1.
1997
Kay, L.; Daneshrad, Z.; Saks, V.A.; Rossi, A. (1997). Alteration in the control of mitochondrial respiration by outer mitochondrial membrane and creatine during heart preservation. Cardiovascular Research, 34 (3), 547−556.
1.1.
1997
Kay, L.; Saks, V.A.; Rossi, A. (1997). Early alteration of the control of mitochondrial function in myocardial ischemia. Journal of Molecular and Cellular Cardiology, 29 (12), 3399−3411.
1.1.
1997
Kay, L.; Li, ZL.; Mericskay, M.; Olivares, J.; Tranqui, L.; Fontaine, E.; Tiivel, T.; Sikk, P.; Kaambre, T.; Samuel, JL.; Rappaport, L.; Usson, Y.; Leverve, X.; Paulin, D.; Saks, VA. (1997). Study of regulation of mitochondrial respiration in vivo An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochimica et Biophysica Acta - Bioenergetics, 1322 (1), 41−59.10.1016/S0005-2728(97)00071-6.
1.1.
1996
Pelouch, V.; Kolar, F.; Khuchua, Z.; Elizarova, G.; Milerova, M.; Oštadal, B.; Saks, V. (1996). Cardiac phosphocreatine deficiency induced by GPA during postnatal development in rat. Molecular and Cellular Biochemistry, 164, 67−76.
1.1.
1996
Saks, V.A.; Ventura-Clapier, R.; Aliev, M. (1996). Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells. Biochimica et Biophysica Acta, 1274 (3), 81−88.
1.1.
1996
Saks, V.A.; Aliev, M.K. (1996). Is there the creatine kinase equilibrium in working heart cells? Biochemical and Biophysical Research Communications, 227 (2), 360−367.
1.1.
1996
Nascimben, L.; Ingwall, J.; Pauletto, P.; Friedrich, J.; Gwathmey, J.K.; Saks, V.A.; Pessina, A.C.; Allen, P.D. (1996). Creatine kinase system in failing and nonfailing human myocardium. Circulation, 94 (8), 1894−1901.
1.1.
1996
Saks, VA.; Tiivel, T.; Kay, L.; NovelChate, V.; Daneshrad, Z.; Rossi, A.; Fontaine, E.; Keriel, C.; Leverve, X.; VenturaClapier, R.; Anflous, K.; Samuel, JL.; Rappaport, L. (1996). On the regulation of cellular energetics in health and disease. Molecular and Cellular Biochemistry, 161, 195−208.
1.1.
1996
Kuznetsov, AV.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Daneshrad, Z.; Rossi, A.; Kadaja, L.; Peet, N.; Seppet, E.; Saks, VA. (1996). Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. European Journal of Biochemistry, 241 (3), 909−915.
1.1.
1996
Bichevin, V.; Kaambre, H.; Sammelselg, V.; Kelle, H.; Asari, E.; Saks, O. (1996). Exoemissive noise activity of different metallic materials. Review of Scientific Instruments, 67 (11), 3951−3953.
1.3.
1996
Martin, Ivar; Männik, Erik; Lille, Ülo; Lakomkin, Vladimir; Steinschneider, Aleksandr; Kuznetsov, Andrei; Ljapina, Svetlana; Saks, Valdur (1996). The effect of the trimer of 16,16-dimethyl-15-keto-PGB1 on metabolic and functional post-ischemic recovery of the heart. Proceedings of the Estonian Academy of Sciences. Biology, 3/4, 93−101.
3.1.
1996
Saks, V.A.; Stepanov, V.A.; Jaliashvili, I.V.; Konorev, E.A.; Kryzanovsky, S.; Ettore, Strumia (1996). Molecular and cellular mechanisms of action for the cardioprotective and therapeutic role of creatine phosphate. M. Conway, J.F.Clark. Creatine and Creatine phosphate: scientific and clinical perspectives (91−114).. San Diego- London - New York: Academic Press.
1.1.
1995
Saks, V.; Belikova, Y.; Vasilyeva, E.; Kuznetsov, A.; Fontaine, E.; Keriel, C.; Leverve, X. (1995). Correlation between degree of rupture of outer mitochondrial membrane and changes of kinetics of regulation of respiration by ADP in permeabilized heart and liver cells. Biochemical and Biophysical Research Communications, 208 (3), 919−926.
1.1.
1995
Novel-Chate, V.; Aussedat, J.; Saks, V.A.; Rossi, A. (1995). Adaptation to chronic hypoxia alters cardiac metabolic response to  stimulation: novel face of phosphocreatine overshoot phenomenon. Journal of Molecular and Cellular Cardiology, 27 (8), 1679−1687.
1.1.
1995
Fontaine, E.M.; Keriel, C.; Lantuejoul, S.; Rigoulet, M.; Leverve, X.M.; Saks, V. (1995). Cytoplasmic cellular structures control permeability of outer mitochondrial membrane for ADP and oxidative phosphorylation in rat liver cells. Biochemical and Biophysical Research Communications, 213 (1), 138−146.
1.1.
1995
Saks, VA.; Kuznetsov, AV.; Khuchua, ZA.; Vasilyeva, EV.; Belikova, JO.; Kesvatera, T.; Tiivel, T. (1995). Control of cellular respiration in-vivo by mitochondrial outer-membrane and by creatine-kinase - a new speculative hypothesis - possible involvement of mitochondrial-cytoskeleton interactions. Journal of Molecular and Cellular Cardiology, 27 (1), 625−645.
3.4.
1995
Saks, V.A.; Kay, L.; Rossi, A.; Toompuu, M.; Utno, L.; Rätsep, I.; Sulling, T. (1995). A novel method for evaluation of efficiency of heart preservation and intraoperational protection by analysis of the respiration of skinned cardiac fibers. Heart Surgery 1995: 6th International Symposium on Cardiac Surgery. Rome (Italy), May 29-June 1st. Rome (Italy), 197−212.
1.1.
1994
Clark, J. F.; Khuchua, Z.; Kuznetsov, A.V.; Vassileva, E.; Boehm, E.; Radda, G. K.; Saks, V. A. (1994). Actions of the creatine analogue beta-guanidinopropionic acid on rat heart mitochondria. Biochemical Journal, 300, 211−216.
1.1.
1994
Saks, V. A.; Khuchua, Z. A.; Vasilyeva, E. V.; Belikova, Y. O.; Kuznetsov, A. (1994). Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration. A Synthesis. Molecular and Cellular Biochemistry, 133, 155−192.
1.1.
1994
Clark, J.F.; Kuznetsov, A.V.; Khuchua, Z.; Veksler, V.; Ventura-Clapier, R.; Saks, V. (1994). Creatine kinase function in mitochondria isolated from gravid and non-gravid guinea - pig uteri. FEBS Letters, 347, 147−151.
1.1.
1994
Saks, V. A.; Khuchua, Z. A.; Vasilyeva, E. V.; Belikova, Y. O.; Kuznetsov, A. (1994). Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration. A Synthesis. Saks V. A., Ventura-Clapier R.. Cellular Bioenergetics. Role of coupled creatine kinase (155−192).. Dordrecht-Boston-London: Kluwer Academic Publishers.
1.1.
1994
Aliev, M. K.; Saks, V. A. (1994). Mathematical modelling of intracellular transport processes and the creatine kinase systems: a probability approach. Saks V. A., Ventura-Clapier R.. Cellular Bioenergetics. Role of coupled creatine kinase (333−346).. Dordrecht-Boston-London: Kluwer Academic Publishers.
1.1.
1994
Panchenko, E.; Dobrovolsky, A.; Rogoza, A.; Sorokin, E.; Ageeva, N.; Markova, L.; Titaeva, E.; Anuchin, V.; Karpov, Y.; Saks, V. (1994). The effect of exogenous phosphocreatine on maximal walking distance, blood rheology, platelet aggregation, and fibrinolysis in patients with intermittent claudication. International Angiology, 13 (1), 59−64.
1.1.
1994
Seppet, EK.; Saks, VA. (1994). Thyroid-hormones and the creatine-kinase system in cardiac-cells. Molecular and Cellular Biochemistry, 133, 299−309.
2.1.
1994
Saks, V. A.; Ventura-Clapier, R. (toim.) (1994). Cellular Bioenergetics. Role ocoupled creatine kinase. Dordrecht-Boston: Kluwer Academic Publishers.
3.2.
1994
Kapelko, V. I.; Popovich, M. I.; Veksler, V. I.; Ventura-Clapier, R.; Khuchua, Z.A.; Saks, V. A. (1994). Subcellular basis for increased diastolic stiffness in experimental cardiomyopathies. Nagano M., Takeda N., Dhalla N. S.. The Cardiomyopathic Heart (185−195).. New York: Raven Press.
3.2.
1994
Saks, V. A.; Vasilyeva, E. V.; Khuchua, Z. A.; Belikova, Y. O.; Aliev, M. K.; Kesvatera, T.; Tiivel, T.; Anflous, K.; Ventura-Clapier, R.; Keriel, Ch.; Fontaine, E.; Leverve, X. (1994). ADP diffusion gradients and metabolic oscillatory signals to mitochondria in the heart and liver cells. Gnaiger E., Gellerich F., Wyss M., Steinlechner R., Azzone G. F.. What is controlling life. Modern trends in Biothermokinetics (178−180).. Innsbruck: Innsbruck University Press.
1.1.
1993
Nemirovskaia, T.L.; Shenkman, B.S.; Nekrasov, A.N.; Kuznetsov, A.V.; Saks, V.A. (1993). Effect of training on the structural-metabolic indicators in athletes skeletal muscles. Biokhimiya, 58 (3), 471−479.
1.1.
1993
Saks, V.A.; Vassilyeva, E.V.; Belikova, YU.O.; Kuznetsov, A.V.; Lyapina, A.; Petrova, L.; Perov, N.A. (1993). Retarded diffusion of ADP in cardiomyocytes: Possible role of outer mitochondrial membrane and creatine kinase in cellular regulation of oxidative phosphorylation. Biochimica et Biophysica Acta, 1144 (2), 134−148.
1.1.
1993
Aliev, M.K.; Saks, V. A. (1993). Quantitative analysis of the "phosphocreatine shuttle": I. A probability approach to the description of phosphocreatine production in the coupled creatine kinase - ATP/ADP translocase - oxidative phosphorylation reactions in heart mitochondria. Biochimica et Biophysica Acta, 1143 (3), 291−300.
1.1.
1993
Saks, V.A.; Strumia, E. (1993). Phosphocreatine: Molecular and cellular aspects of the mechanism of cardioprotective action. Current Therapeutical Research, 53 (5), 565−598.
1.3.
1993
Galyautdinov, G.S.; Saks, V.A.; Kots, YA.I.; Vdovenko, L.G. (1993). Clinical application of phosphocreatine (Neoton) in congestive heart failure. I. Evaluation of general clinical efficiency. Il. Cuore, 10 (2), 185−193.
1.1.
1992
Dzhavadov, S.A.; Dzokharidze, T.Z.; Dzhaliashvili, I.V.; Gelfgat, E.S.; Saks, V.A.; Pogacha, G. (1992). Energy metabolism and contractile function of the heart in diabetic cardiomyopathy: effect of ischemia and reperfusion. Biokhimiya, 57 (12), 1917−1929.
1.1.
1992
Korchazkina, O. V.; Lakomkin, V. L.; Veksler, V. I.; Elizarova, G. V.; Saks, V. A.; Kapelko, V. I.; Kupriyanov, V. V. (1992). Metabolic and functional consequances of complete inhibition of creatine kinase by iodoacetamide in the perfused heart. Biokhimiya, 57 (2), 203−213.
1.1.
1992
Branishte, T.A.; Kuznetsov, A.V.; Khuchua, Z.A.; Samko, A.N.; Naumov, V.G.; Semenovsky, M.L.; Belenkov, Iu.N.; Saks, V.A. (1992). Cellular mechanisms of impaired cardiac energetics in patients with dilated cardiomyopathy: decrease in mitochondrial respiration and creatine kinase expression. Kardiologiya, 32 (5), 13−16.
1.1.
1992
Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Korchazhkina, O.V.; Ruuge, E.K.; Saks, V.A. (1992). Functional significance of 2 pathways of energy transport in cardiomyocytes. Kardiologiya, 32 (4), 71−74.
1.1.
1992
Saks, V.A.; Konorev, E.A.; Grigoriants, R.A.; Belenkov, Iu.N. (1992). Biochemistry of normal and ischemic cardiomyocytes: current state of studies. Kardiologiya, 32 (3), 82−91.
1.1.
1992
Kuznetsov, A.V.; Veksler, V.I.; Sharov, V.G.; Dzhavadov, S.A.; Saks, V.A. (1992). Quantitative relatioship between ischemic heart disease and parameters of energy metabolism. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 3, 21−26.
1.1.
1992
Jaliashvili, I.V.; Konorev, E.A.; Medvedeva, N.V.; Lakomkin, V.L.; Saks, V.A. (1992). The role of calcium ions in the molecular mechanism of the protective mechanism of exogenous phosphocreatine. Biokhimiya, 57 (2), 300−311.
1.1.
1992
Saks, V. A.; Dzhaliashvili, I. V.; Konorev, E. A.; Strumia, E. (1992). Molecular and cellular aspects of the cardioprotective mechanism of phosphocreatine. Biokhimiya, 57 (12), 1763−1784.
1.1.
1992
Moibenko, A.A.; Marchenko, G.I.; Kotsuruba, V.N.; Popovich, L.F.; Zarzhevskaya, V.K.; Saks, V.A. (1992). Effect of exogenous phosphocreatine on endothelium endothelium-dependent vascular reactions in immune cardiac injury. Current Therapeutical Research, 52 (6), 791−801.
1.2.
1992
Khuchua, Z.A.; Kuznetsov, A.V.; Vassilyeva, E.V.; Ventura-Clapier, R.; Clark, J.; Steinschneider, A.Ya.; Korchazhkina, O.V.; Lakomkin, V.L.; Branishte, Th.; Ruuge, E.K.; Kapelko, V.I.; Saks, V.A. (1992). The creatine kinase system and cardiomyopathy. The American Journal of Cardiovascular Pathology, 4 (3), 223−234.
1.3.
1992
Saks, V. A.; Ventura-Clapier, R. (1992). Biochemical organization of energy metabolism in muscle. J. Biochem. Organization, 1, 9−30.
3.2.
1992
Saks, V.A.; Kapelko, V.I.; Ruda, M.Y.; Semenovsky, M.L.; Strumia, E. (1992). Phosphocreatine as effective drug in clinical cardiology. P.P.De Deyn, B.Marsecau, V.Stalon and I.A.Qureshi. Guanidino Compounds in Biology and Medicine (239−248).. John Libbey & Company Ltd..
1.1.
1991
Klushnik, T.P.; Spunde, A.Ya.; Yakovlev, A.G.; Khuchua, Z.A.; Saks, V.A.; Vartanyan, M.E. (1991). b21552150Intracellular alterations of the creatine kinase isoforms in brains of schizophrenic patients. Molecular and Chemical Neuropathology, 15 (3), 271−278.
1.1.
1991
Konorev, E.A.; Medvedeva, N.V.; Dzhaliashvili, I.V.; Lakomkin, V.L.; Saks, V.A. (1991). Participation of calcium ions in the molecular mechanism of cardioprotective action of exogenous phosphocreatine. Basic research in cardiology, 86 (4), 327−339.
1.1.
1991
Konorev, E.A.; Medvedeva, N.V.; Dzhaliashvili, I.V.; Stepanov, V.A.; Saks, V.A. (1991). Effects of phosphocreatine and its structural analogues on membranes. Biokhimiya, 56 (9), 1701−1709.
1.1.
1991
Saks, V.A.; Belikova, Yu.O.; Kuznetsov, A.V. (1991). In vivo regulation of mitochondrial respiration in cardiomyocytes: Specific restrictions for intracellular diffusion of ADP. Biochimica et Biophysica Acta, 1074 (2), 302−311.
1.1.
1991
Konorev, E.A.; Sharov, V.G.; Saks, V.A. (1991). Improvement in contractile recovery of isolated rat heart after cardiologic ischemic arrest with endogenous phosphocreatine: Involvement of antiperoxidative effect? Cardiovascular Research, 25 (2), 164−171.
1.1.
1991
Seppet, EK.; Kairane, CB.; Khuchua, ZA.; Kadaya, LY.; Kallikorm, AP.; Saks, VA. (1991). Hormone regulation of cardiac energy-metabolism. 3. Effect of thyroid state on distribution of creatine-kinase isoenzymes and creatine-controlled respiration in cardiac-muscle. Journal of Applied Cardiology, 6 (5), 301−311.
1.1.
1991
Seppet, EK.; Kadaya, LY.; Hata, T.; Kallikorm, AP.; Saks, VA.; Vetter, R.; Dhalla, NS. (1991). Thyroid control over membrane processes in rat-heart. American Journal of Physiology, 261 (4), 66−71.
1.1.
1990
Konorev, E.A.; Saks, A.A.; Sharov, V.G.; Makhotina, L.A. (1990). Oxidative myocardial damage: Protective action of exogenous phosphocreatine. Biulleten eksperimental'noi biologii i meditsiny, 109 (3), 224−226.
1.1.
1990
Belikova, Yu.O.; Kuznetsov, A.V.; Saks, V.A. (1990). Specific restriction for intracellular diffusion of ADP in cardiomyocytes. Biokhimiya, 55 (11), 1944−1957.
1.1.
1990
Seppet, EK.; Kadaya, LY.; Kallikorm, AP.; Saks, VA. (1990). Hormone regulation of cardiac energy-metabolism. 2. The effect of thyroid state on the coupling between the reactions of oxidative-phosphorylation and phosphocreatine synthesis in rat-heart mitochondria. Journal of Applied Cardiology, 5 (5), 367−381.
1.1.
1990
Seppet, EK.; Kadaya, AI.; Kallikorm, AP.; Saks, VA. (1990). Synthesis of phosphocreatine in myocardial mitochondria of hyperthyroid rats. Biochemistry (Moscow), 55 (6), 809−814.
1.1.
1989
Konorev, E.A.; Saks, V.A.; Sharov, V.G.; Yevstigneeva, R.P. (1989). Improvement of contraction and metabolism of rat isolated heart in postischemic reperfusion with phosphocreatine and tocopheryl phosphate and their combinations. Vestnik Akademii Meditsinskikh Nauk SSSR, 12, 55−63.
1.1.
1989
Sharov, V.G.; Beskrovnova, N.N.; Kryzhanovsky, S.A.; Bobkov, J.G.; Saks, V.A.; Kaverina, N.V. (1989). Ultrastructure of Purkinje cells in the subendocardium and false tendons in early experimental myocardial infarction complicated by fibrillation in the dog. Virchows Archiv B-Cell Pathology, 57 (2), 131−139.
1.1.
1989
Kuznetsov, A.V.; Khuchua, Z.A.; Vassilyeva, E.V.; Medvedeva, N.V.; Saks, V.A. (1989). Heart mitochondrial creatine kinase revisited: The outer mitochondrial membrane is not important for coupling of phosphocreatine production to oxidative phosphorylation. Archives of Biochemistry and Biophysics, 268 (1), 176−190.
1.1.
1989
Kuznetsov, A.V.; Veksler, V.I.; Sharov, V.G.; Kapelko, V.I.; Saks, V.A. (1989). Estimation of functional parameters of mitochondria insitu by recording respiration of skinned heart figers. Bulletin of Experimental Biology and Medicine, 107 (2), 174−176.
1.1.
1989
Khuchua, Z.A.; VenturaClapier, R.; Kuznetsov, A.V.; Grishin, M.N.; Saks, V.A. (1989). Alteration in the creatine kinase in the myocardium of the cardiomyopathic hamsters. Biochemical and Biophysical Research Communications, 165 (2), 748−757.
1.3.
1989
Semenovsky, M.L.; Mogilevsky, G.M.; Shumakov, V.I.; Sharov, V.G.; Saks, V.A. (1989). Metabolic protection of myocardium during surgery: Blood cardioplegia in combination with exogenous phosphocreatine. Sov. Med. Rev. A. Cardiol, 2, 233−266.
1.3.
1989
Afonskaya, N.I.; Samarenko, M.B.; Vikhert, A.M.; Cherpachenko, N.M.; Sharov, V.G.; Saks, V.A.; Ruda, M.Ya. (1989). Phosphocreatine in the treatment of patients with acute myocardial infarction. Sov. Med. Rev. A. Cardiol, 2, 267−294.
1.1.
1988
Ruda, M.Ya.; Samarenko, M.B.; Afonskaya, N.I.; Saks, V.A. (1988). Reduction of ventricular arrythmias by phosphocreatine (Neoton) in patients with acute myocardial infarction. American Heart Journal, 116 (2), 393−397.
1.1.
1988
Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Severina, M.Yu.; Veksler, V.I.; Saks, V.A. (1988). The cardiac contractile failure induced by chronic creatine and phosphocreatine deficiency. Journal of Molecular and Cellular Cardiology, 20 (6), 465−479.
1.1.
1988
Kupriyanov, V.V.; Lakomkin, V.L.; Steinschneider, A.Ya.; Severina, M. Yu.; Kapelko, V.I.; Ruuge, E.K.; Saks, V.A. (1988). Relationships between pre-ischemic ATP and glycogen content and post-ischemic recovery of rat heart. Journal of Molecular and Cellular Cardiology, 20 (12), 1151−1162.
1.1.
1988
Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Zueva, M.Yu.; Saks, V.A. (1988). Mechanisms of the cardiac contractile function and energy metabolism adaptation to conditions of chronic depletion of phosphocreatine. Fiziologicheskii Zhurnal, 34 (1), 3−11.
1.1.
1988
Seppet, EK.; Eimre, MA.; Kallikorm, AP.; Saks, VA. (1988). Effect of exogenous phosphocreatine on heart-muscle contractility modulated by hyperthyroidism and extracellular calcium-concentration. Journal of Applied Cardiology, 3 (6), 369−380.
1.3.
1988
Saks, V.A.; Machotina, L.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Kapelko, V.I.; Preobrazhansky, A.N.; Medvedeva, N.V.; Vititnova, M.B.; Kacharava, V.P.; Kryzhanovsky, S.A.; Konorev, E.A.; Pitchugin, V.V.; Sharov, V.G.; Kaverina, N.V. (1988). Sechenov Physiological Journal of the USSR. Bull. Cardiology Research Centre USSR, 2, 42−50.
1.1.
1987
Elizarova, G. V.; Sykhanov, A. A.; Saks, V. A. (1987). Myofibrillar creatine kinase reversible binding to contractile proteins, stoichiometric ratio to myosin and functional significance. Biokhimia, 52 (4), 667−675.
1.1.
1987
Saks, V. A.; Khuchua, Z. A.; Kuznetsov, A. V. (1987). Specific inhibition of ATP-ADP translocase in cardiac mitoplasts by antibodies against mitochondrial creatine kinase. Biochimica et Biophysica Acta, 891 (2), 138−144.
1.1.
1987
Veksler, V. I.; Kuznetsov, A. V.; Sharov, V. G.; Kapelko, V. I.; Saks, V. A. (1987). Mitochondrial respiratory parameters in cardiac tissue a novel method of assessment by using saponin-skinned fibers. Biochimica et Biophysica Acta, 892 (2), 191−196.
1.1.
1987
Kupriyanov, V.V.; Steinschneider, A.Ya.; Lakomkin, V.L.; Zueva, M.Yu.; Kapelko, V.I.; Saks, V.A. (1987). Metabolism of exogenous phosphocreatine and 3-phosphono-2-imino-1-methyl-4-oxoimidazolodine in perfused rat heart during ischemia. Biokhimia, 52 (3), 437−444.
1.1.
1987
Shteinshneider, A.Ya.; Kupriyanov, V.V.; Ruuge, E.K.; Saks, V.A. (1987). 3-Phosphono-2-imino-1-methyl-4-oxoimidazolidine is a competitive substrate of AMP-dephosphorylating enzymes in rat heart cytosol. Biokhimia, 52 (4), 577−583.
1.1.
1987
Kapelko, V. I.; Saks, V. A.; Novikova, N. A.; Golikov, M. A.; Kupriyanov, V. V.; Popovoch, M. I. (1987). Adaptation of cardiac contractile function to conditions of chronic energy. Journal of Molecular and Cellular Cardiology, 19 (Suppl IV), 61.
1.1.
1987
Saks, V. A.; Kuznetsov, A. V.; Javadov, S. A.; Kupriyanov, V. V.; Sharov, V. G.; Veksler, V. I.; Kapelko, V. I. (1987). Contents of high energy phosphates and rates of mitochondrial oxidative reactions: significance for cardiac contractile function. Journal of Molecular and Cellular Cardiology, 19 (Suppl. IV), 60.
1.1.
1987
Khuchua, Z.A.; Kuznetsov, A.V.; Chernousova, G.B.; Lyulina, N.V.; Saks, V.A. (1987). Immunochemical study on the structural basis of functional coupling between creatine kinase and ATP-ADP translocase in heart mitochondria. Biologicheskie Membrany, 4 (4), 415−425.
1.1.
1987
Ventura-Clapier, R.; Saks, V. A.; Vassort, Guy; Lauer, Claudine; Elizarova, G. V. (1987). Reversible MM-creatine kinase binding to cardiac myofibrils. American Journal of Physiology-Cell Physiology, 253 (22), 444−455.
1.1.
1987
Ventura-Clapier, R.; Veksler, V. I.; Elizarova, G. V.; Mekfi, H.; Levitskaya, E. L.; Saks, V. A. (1987). Contractile properties and creatine kinase activity of myofilaments following ischemia and reperfusion of the rat heart. Biochemical Medicine and Metabolic Biology, 38 (3), 300−310.
1.1.
1987
Sharov, V. G.; Saks, V. A.; Kupriyanov, V. V.; Lakomkin, V. L.; Kapelko, V. I.; Steinschneider, A. Ya.; Javadov, S. A. (1987). Protection of ischemic myocardium by exogenous phosphocreatine (Neoton): I. Morphological and 31p-NMR studies. Journal of Thoracic and Cardiovascular Surgery, 94 (5), 749−761.
1.1.
1987
Kupriyanov, V. V.; Lakomkin, V. L.; Steinschneider, A. Ya.; Novikova, N. A.; Severina, M. Yu.; Kapelko, V. I.; Saks, V. A. (1987). The role of phosphocreatine and ATP in contraction of normal and ischemic heart. Biomedica Biochimica Acta, 46, 493−498.
1.1.
1987
Kupriyanov, V. V.; Lakomkin, V. L.; Kapelko, V. I.; Steinschneider, A. Ya.; Ruuge, E. K.; Saks, V. A. (1987). Dissociation of adenosine triphosphate levels and contractile function in isovolumic hearts perfused with 2-deoxyglucose. Journal of Molecular and Cellular Cardiology, 19 (8), 729−744.
1.1.
1987
Semenovsky, M. L.; Shumakov, V. I.; Sharov, V. G.; Mogilevsky, G. M.; Asmolovsky, A. V.; Makhotina, L. A.; Saks, V. A. (1987). Protection of ischemic mytocardium by exogenous phosphocreatine. II. Clinical, ultrastructural and biochemical evaluations. Journal of Thoracic and Cardiovascular Surgery, 94 (5), 762−769.
1.1.
1987
Seppet, EK.; Kallikorm, AP.; Javadov, SA.; Preobrazhensky, AN.; Lakomkin, VA.; Saks, VA. (1987). Energy-dependence of heart contractility impairment in conditions of calcium overload. Kardiologiya, 27 (7), 72−76.
3.1.
1987
Saks, V. A.; Kapelko, V. I.; Kupriyanov, V. V.; Khuchua, Z. A.; Lakomkin, V. L.; Novikova, N. A.; Ruuge, E. K.; Sharov, V. G.; Steinschneider, A. Ya.; Zueva, M. Yu. (1987). Control of energy transport in cardiac muscle. Dissociation of ATP levels from contractile function: cardiac failure due to phosphocreatine dediciency. Dhalla N. S., Pierce G. N., Beamish R. E.. Heart function & Metabolism (377−395).. Boston: Martinus Nijhoff Publishers.
3.2.
1987
Saks, V. A.; Bobkov, I. G. (1987). Creatine phosphate: biochemistry, pharmacology and clinical efficiency. Strumia, E.... Torino: Edizoni Minerva Medica.
3.2.
1987
Lakomkin, V. L.; Steinschneider, A. Ya.; Novikova, N. A.; Kapelko, V. I.; Saks, V. A. (1987). Phosphocreatine, ATP in energy supply for cardiac contraction. Metabolism and Development of Nervous System (276−281).. Chichester; Prague: Academia.
3.2.
1987
Kupriyanov, V. V.; Balaban, R. S.; Steinschneider, A. Ya.; Lakomkin, V. L .; Ruuge, E. K.; Smirnov, V. N.; Saks, V. A. (1987). 31p-NMR study of creatine kinase reaction mechanism in vitro and in vivo. Smirnov V. N ., Katz A .. Myocardial metabolism Cardiology reviews, suppl. 2 (120−130).. London: Harwood Academic Publishers.
3.2.
1987
Saks, V. A.; Sharov, V. G.; Kupriyanov, V. V.; Krizhanovsky, S. A.; Semenovsky, M. L.; Mogilevsky, G. M.; Lakomkin, V. L.; Steinschneider, A. Ya.; Preobrazhensky, A. N.; Javadov, S. A.; Anyukhovsky, E. P.; Beskrovnova, N. A.; Rosenschtraukh, L. V.; Kaverina, N. V. (1987). Phosphocreatine and related compounds: protective action on the ischemic myocardium. Smirnov V. N., Katz A.. Myocardial metabolism. Cardiology reviews, suppl. 2 (189−200).. London: Harwood Academic Publishers.
3.2.
1987
Saks, V. A.; Javadov, S. A.; Pozin, E.; Preobrazhensky, A. N. (1987). Biochemical basis of the protective action of phosphocreatine on the ischemic myocardium. L. D` Alessandro Case. Heart surgery-87 (155−170).. Roma: Editrice Scietifica Internationale.
1.1.
1986
Kupriyanov, V. V.; Lyulina, N. V.; Steinschneider, A. Ya.; Zueva, M. Yu.; Saks, V. A. (1986). Creatine kinase - catelyzed ATP-phosphocreatine exchange. Comparison of 31p-NMR saturation transfer technique and radioisotope tracer methods. FEBS Letters, 208 (1), 89−93.
1.1.
1986
Dzhavadov, S. A.; Preobrazhensky, A. N.; Saks, V. A. (1986). Effect of phosphocreatine on the lysophosphoglyceride level during total ischemia of rat myocardium. Biokhimia, 51 (4), 668−674.
1.1.
1986
Preobrazhensky, A.N.; Javadov, S.A.; Saks, V.A. (1986). Study on the hypothetical mechanism of protective effect of phosphocreatine on ischemic myocardium. Biokhimia, 51 (4), 675−683.
1.1.
1986
Saks, V.A.; Vassort, G.; Ventura-Clapier, R. (1986). Reversible MM-creatine kinase binding to Triton-treated isolated rat papillary muscles. Journal of Physiology-London, 377, 117.
1.1.
1986
Anyukhovsky, E. P.; Javadov, S. A.; Preobrazhensky, A. N.; Beloshapko, G. G.; Rosenshtraukh, L. V.; Saks, V.A. (1986). Effect f phosphocreatine and related compounds on the phospholipid metabolism of ischemic heart. Biochemical Medicine and Metabolic Biology, 35 (3), 327−334.
1.1.
1986
Chazov, E.I.; Semenovsky, M.L.; Smirnov, V.N.; Shumakov, V.I.; Saks, V.A.; Sharov, V.G.; Mogilevsky, G.M.; Severin, V.V.; Asmolovsky, A.V.; Makhotina, L.A. (1986). Morphological and biochemical criteria of the efficiency of clinical application of phosphocreatine (Neoton) for intraoperational protection of myocardium. Fiziologicheskii Zhurnal, 32 (1), 3−13.
1.1.
1986
Sharov, V. G.; Afonskaya, N. I.; Ruda, M. Y.; Cherpachenko, N. M.; Posin, G. Ya.; Markosyan, R. A.; Shepeleva, I. I.; Samarenko, M. B.; Saks, V. A. (1986). Protection of ischemic myocardium by exogenous phosphocreatine (Neoton): Pharmacokinatics of phosphocreatine, reduction of infarct size, stabilization of sarcolemma of ischemic cardiomyocytes and antithrombotic action. Biochemical Medicine and Metabolic Biology, 35 (1), 101−114.
1.1.
1986
Kuznetsov, A. V.; Saks, V. A. (1986). Affinity modification of creatine kinase and ATP-ADP translocase in heart mitochondria determination of their molar stoichiometry. Biochemical and Biophysical Research Communications, 134 (1), 359−366.
1.1.
1986
Saks, V. A.; Khuchua, Z. A.; Kuznetsov, A. V.; Veksler, V. I.; Sharov, V. G. (1986). Heart mitochondria in physiological salt solution not ionic strength but salt composition is important for association of creatine kinase with the inner membrane surface. Biochemical and Biophysical Research Communications, 139 (3), 1262−1271.
3.1.
1986
Saks, V. A.; Kuznetsov, A. V.; Khuchua, Z.; Kupriyanov, V. V. (1986). Compartmentation of adenine nucleotides and phosphocreatine shuttle in cardiac cells some new evidence. Brautbar N.. Advances in experimental medicine and biology (103−116).. New York: Plenum Press.
3.2.
1986
Belenkov, Yu. N.; Saks, V. A.; Sharov, V. G.; Semenovsky, M. L.; Mogilevsky, G. M.; Afonskaya, N. I.; Ruda, M. Y.; Samarenko, M. B. (1986). Phosphocreatine action on ischemic myocardium experimental research and clinical trial. Mason Ztacia. Progress in Molecular Genetics and Frontiere della Cardiologia (111−133).. Milano: x.
5.1.
1986
Seppet, E.; Kallikorm, A.; Saks, V.; Antaloczy, Z. (1986). Effect of phosphocreatine on hyperthyroid rat-heart contractility. Acta Physiologica Hungarica, 68, 282−282.
1.1.
1985
Rosenshtraukh, L. V.; Saks, V. A.; Anyukovsky, E. P.; Beloshapko, G. G.; Yushmanova, A. V. (1985). The antiarrhythmic action of phosphocreatine in acute myocardial ischemia. Biochemical Medicine, 34 (1), 120−128.
1.1.
1985
Seppet, EK.; Aodyaan, AJ.; Kallikorm, AP.; Chernousova, GB.; Lyulina, NV.; Sharov, VG.; Severin, VV.; Popovich, MI.; Saks, VA. (1985). Hormone regulation of cardiac energy-metabolism. 1. Creatine transport across cell-membranes of euthyroid and hyperthyroid rat-heart. Biochemical Medicine, 34 (3), 267−279.
1.1.
1985
Saks, V. A.; Kuznetsov, A. V.; Kupriyanov, V. V.; Miceli, M. V.; Jacobus, W. J. (1985). Creatine kinase of rat heart mitochondria. The demostration of functional coupling to oxidative phosphorylation in an inner membrane-matrix preparation. Journal of Biological Chemistry, 260 (12), 7757−7764.
1.1.
1985
Mogilevsky, G.M.; Sharov, V.G.; Saks, V.A.; Semenovsky, M.L. (1985). Structural-biochemical characterization of the efficiency of the intraoperational myocardium protection. Arkhiv Patologii, 47 (6), 24−29.
1.3.
1985
Kupriyanov, V.V.; Steinschneider, A.Ya.; Lakomkin, V.L.; Ruuge, E.K.; Kapelko, V.I.; Saks, V.A. (1985). 31P-NMR study of protective effect of phosphocreatine on ischemic myocardium under cardioplegia. Bull. Cardiology Research Centre USSR, 1, 14−19.
3.2.
1985
Saks, V. A.; Sharov, G.; Kupriyanov, V. V.; Semenovsky, M. L.; Mogilevsky, G. M.; Lakomkin, V. L.; Steinschneider, A. Ya.; Afonskaya, N. I.; Ruda, M.Ya.; Samarenko, M. B. (1985). Phosphocreatine and myocardial protection: biochemical, pharmacological and clinical aspects. Conoscere e curare il cuore 85 (348−373).. Rome: Schiaparelli Farmaceutici.
3.4.
1985
Saks, V. A.; Kupriyanov, V. V.; Ventura-Clapier, R. (1985). Mechanism of energy supply for contraction: biochemical and NMR studies. Proceedings of the 16th FEBS Congress, part A. VNU Science press, 281−290.
1.1.
1984
Kupriyanov, V. V.; Steinschneider, A. Ya.; Ruuge, E. K.; Kapelko, V. I.; Zueva, M. Ya.; Lakomkin, V. L.; Smirnov, V. N.; Saks, V. A. (1984). Regulation of energy flux through the creatine kinase reaction in vitro and in perfused rat heart. 31p-NMR Studies. Biochimica et Biophysica Acta, 805 (4), 319−331.
1.1.
1984
Saks, V. A.; Ventura-Clapier, R.; Khuchua, Z. A.; Preobrazhensky, A. N.; Emelin, I. V. (1984). Creatine kinase in regulation of heart function and metabolism. I Further evidence for compartmentation of adenine nucleotides in cardiac myofibrillar and sarcolemmal coupled ATPase-creatine kinase systems. Biochimica et Biophysica Acta, 803 (4), 254−264.
1.1.
1984
Seppet, EK.; Adoyaan, AI.; Kallikorm, AP.; Chernousova, GV.; Lyulina, NV.; Severin, VV.; Popovich, MI.; Saks, VA. (1984). Hyperthyroid cardiomyopathy - abnormalities in creatine transport and hypersensitivity to ischemic-injury. Vestnik Akademii Meditsinskikh Nauk SSSR, 10, 48−56.
1.2.
1984
Saks, V. A.; Sharov, V. G.; Kupriyanov, V. V.; Smirnov, V. N.; Semenovsky, M. L. (1984). Protective action of phosphocreatine on ischemic myocardium. Journal of Molecular and Cellular Cardiology, 16 (Suppl. 2), 113.
3.1.
1984
Saks, V. A.; Chernousova, G. B.; Lyulina, N. V.; Khuchua, Z. A.; Preobrazhensky, A. N.; Ventura-Clapier, R. (1984). Role of multienzyme complexes in intracellular compartmentation of adenine nucleotides and in regulation of cardiac energy metabolism. Cellular and molecular aspects of the regulation of the heart (41−48).. Berlin: Akademie Verlag Gmbh.
1.1.
1983
Gellerich, F. N.; Schlame, M.; Saks, V. A. (1983). Creatine kinase of heart mitochondria: no changes in its kinetic properties after inhibition of the adenine nucleotide translocator. Biomedica Biochimica Acta, 42 (10), 1335−1337.
1.1.
1983
Kupriyanov, V. V.; Preobrazhensky, A. N.; Saks, V. A. (1983). Mechanism of passive Ca2+ permeability of vesicular sarcolemmal preparations from rat hearts. Biochimica et Biophysica Acta, 728 (2), 239−253.
1.1.
1983
Kupriyanov, V. V.; Steinschneider, A. Ya.; Ruuge, E. K.; Smirnov, V. N.; Saks, V. A. (1983). 31p-NMR SPECTRUM of phosphocreatine: ducterium-induced splitting of the signal. Biochemical and Biophysical Research Communications, 114 (3), 1117−1125.
1.1.
1982
Preobrazhenskii, A. N.; Kupriyanov, V. V.; Saks, V. A.; Grosse, R.; Spitzer, E. (1982). Effect of cardenolids and sodium ion gradient on ATP - dependent Ca2+ accumulation in cardiac sarcolemmal vesicles. Biokhimia, 47 (1), 126−136.
1.1.
1982
Gellerich, F.; Saks, V. A. (1982). Control of heart mitochondrial oxygen consumption by creatine kinase: the importance of enzyme localization. Biochemical and Biophysical Research Communications, 105 (4), 1473−1481.
1.2.
1982
Saks, V. A.; Kupriyanov, V. V. (1982). Intracellular energy transport and control of cardiac contraction. Advances in Myocardiology, 3, 475−497.
1.2.
1982
Preobrazhensky, A. N.; Saks, V. A. (1982). The cardiac sarcolemmal protein kinase reaction. Kinetic characteristics and sensitivity to cyclic AMP. Advances in Myocardiology, 3, 273−288.
1.1.
1981
Kupriyanov, V. V.; Elizarova, G. V.; Saks, V. A. (1981). Determination of molar content of creatine kinase in cardiac mitochondria by SH - reagents. Biokhimia, 46 (5), 930−941.
1.1.
1981
Preobrazhensky, A.N.; Saks, V.A. (1981). Some properties of the reaction catalyzed by protein kinase bound to cardiac sarcolemma. Biokhimia, 46 (9), 1681−1693.
1.1.
1981
Kupriyanov, V. V.; Preobrazhensky, A. N.; Saks, V. A. (1981). Study of passive Ca2+ permeability of ventricular sarcolemmal preparations from myocardium. Biokhimia, 46 (10), 1863−1879.
1.1.
1980
Saks, V. A.; Kupriyanov, V. V.; Elizarova, G. V.; Jacobus, W. E. (1980). Studies of energy transport in heart cells. The importance of creatine kinase localization for the coupling of mitochondrial phosphorylcreatine production to oxidative phosphorylation. Journal of Biological Chemistry, 255 (2), 755−763.
1.1.
1980
Kupriyanov, V.V.; Panasenko, N.A.; Saks, V.A. (1980). The kinetics of the interaction of analogs of guanidine substrates with muscle creatine kinase. Bioorganicheskaya Khimiya, 6 (1), 116−137.
1.1.
1980
Saks, V.A.; Smirnov, V.N. (1980). Molecular mechanisms of changes in myocardial energy metabolism in pathological conditions. Kardiologiya, 20 (5), 10−12.
1.1.
1980
Grosse, R.; Spitzer, E.; Kupriyanov, V. V.; Saks, V. A.; Repke, K. K. H. (1980). Coordinate interplay between (n+, K+ ) antiport across the membrane of resieles forward from the plasme membrane of cardiac muscle cells. Biochimica et Biophysica Acta, 603 (1), 142−156.
1.1.
1980
Kupriyanov, VV.; Seppet, EK.; Emelin, IV.; Saks, VA. (1980). Phosphocreatine production coupled to the glycolytic reactions in the cytosol of cardiac-cells. Biochimica et Biophysica Acta, 592 (2), 197−210.
3.2.
1980
Rosenshtraukh, L. V.; Saks, V. A.; Sharov, V. G.; Yuryavichyus, I. A.; Chazov, E. I. (1980). Regulation of mechanical and electrical activity of the hypodynamic myocardium by creatine phosphate. Energy transport, protein synthesis and hormonal control of heart metabolism (89−112).. Betheda: US Department of Health and Human Services.
3.2.
1980
Chazov, E. I.; Smirnov, V. N.; Saks, V. A.; Rosenshtraukh, L. V.; Lipina, N. V.; Levitsky, D. O. (1980). Energy metabolism and ion fluxes across cardiac membranes. M. Tajuddin, P. K. Das, M. Tariq, N. S. Dhalla. Advances in myocardiology (1).. Baltimore: University Park Press.
3.2.
1980
Saks, V. A.; Kupriyanov, V. V.; Elizarova, G. V.; Seppet, E. K.; Jacobus, W. E. (1980). Regulation of phosphorylcreatine synthesis in myocardial cells: the coupling of transphosphorylation to glycosis and mitochondrial oxidative phosphorylation and the significance of creatine kinase compartmentation. Energy transport, protein synthesis and hormonal control of heart metabolism (89−112).. Betheda: US Department of Health and Human Services. (NIH Publication ; N 80 - 2017).
3.2.
1980
Saks, V.A. (1980). Creatine kinase isoenzymes and control of cardiac contraction. Jacobus J. W., Ingwall J.. Heart creatine kinase: the integration of isoenzymes for energy distribution (109−124).. Baltimore: Williams & Wilkins.
1.1.
1979
Rosenshtraukh, L. V.; Saks, V. A.; Yuriavichus, I. A.; Nesterenko, N. V.; Undrovinas, A. I.; Smirnov, V. N.; Chazov, E. I. (1979). Effect of creatine phosphate on the slow inward calcium current, action potential and the contractile force of frog attrium and ventricle. Biochemical Medicine, 21 (1), 1−15.
1.1.
1979
Sharov, V.G.; Shepeleva, I.I.; Saks, V.A. (1979). Electron microscopic investigation of permeability of the sarcolemma of rat cardiac myocytes during acute anoxia of the myocardium. Bulletin of Experimental Biology and Medicine, 88 (8), 917−921.
1.1.
1979
Kupriyanov, V.V.; Seppet, E.K.; Emelin, I.V.; Saks, V.A. (1979). Steady state kinetics of pyruvate kinase from muscle. Biokhimia, 44 (1), 104−115.
1.1.
1979
Erashova, N.S.; Saks, V.A.; Sharov, V.G.; Lyzlova, S.N. (1979). Creatine kinase from muscle cell nuclei. Biokhimia, 44 (2), 372−378.
1.1.
1979
Saks, V.A.; Kats, V.M.; Vetter, R.; Lylina, V.N.; Shell, W. (1979). The effect of calcium ions on the creatine kinase systems of myocardial cells. Biokhimia, 44, 1600−1611.
1.1.
1979
Saks, VA.; Seppet, EK.; Smirnov, VN. (1979). Does oxidative-phosphorylation increase the rate of creatine-phosphate synthesis in heart-mitochondria or not. Journal of Molecular and Cellular Cardiology, 11 (12), 1265−1273.
1.1.
1979
Kupriyanov, VV.; Seppet, EK.; Emelin, IV.; Saks, VA. (1979). Steady-state kinetics of muscular pyruvate-kinase. Biochemistry (Moscow), 44 (1), 87−95.
1.3.
1979
Rosenshtraukh, L. V.; Saks, V. A.; Yuriavichus, I. A.; Nesterenko, N. V.; Undrovinas, A. I.; Smirnov, V. N. (1979). Effect of creatine phosphate on the slow inward calcium current, action potential, and the contractile force of frog atrium and ventricle. Fisioliologitšeski Zhurnal SSSR, 65, 405−413.
1.3.
1979
Shepeleva, I.I.; Saprygin, D.B.; Saks, V.A.; Kramer, A.A.; Kashtelyan, L.S. (1979). Experimental substantiation of myocardial affection visualization by means of pyrophosphate-99m Tc. Meditsinskaya Radiologiya, 3, 16−22.
1.1.
1978
Kupriyanov, V.V.; Seppet, E.K.; Saks, V.A. (1978). Creatine phosphate synthesis coupled to the glycolytic reactions in heart cells cytosol. Biokhimia, 43 (8), 1468−1476.
1.1.
1978
Saks, V. A.; Rosenshtraukh, L. V.; Smirnov, V. N.; Chazov, E. I. (1978). Role of creatine phosphokinase in cellular function and metabolism. Canadian Journal of Physiology and Pharmacology, 56 (5), 691−706.
1.1.
1978
Rosenshtraukh, L. V.; Saks, V. A.; Undrovinas, A. I.; Chazov, E. I.; Smirnov, V. N.; Sharov, V. G. (1978). Studies of energy transport in heart cells. The effect of creatine phosphate on the frog ventricular contractile force and action potential duration. Biochemical Medicine, 19 (2), 148−164.
1.1.
1978
Levitsky, D. O.; Levchenko, T. S.; Saks, V. A.; Sharov, V. G.; Smirnov, V. N. (1978). The role of creatine phosphokinase in supplyng energy for the calcium pump system of heart sarcoplasmic reticulum. Membrane Biochemistry, 2 (1), 81−96.
1.1.
1978
Erashova, N. S.; Saks, V. A.; Sharov, V. G.; Lyzlova, S. N. (1978). Creatine kinase bound to cardiac cells nuclei. Biochemical and Biophysical Research Communications, 82 (4), 1217−1222.
1.1.
1978
Sharov, V.G.; Orlova, Z.R.; Saks, V.A. (1978). Ultrastructural bases of acute cardiac insufficiency not associated with rhythm disorders. Arkhiv Patologii, 40 (10), 3−14.
1.1.
1978
Seppet, EK.; Kupriyanov, VV.; Saks, VA. (1978). Adenylate kinase from heart. 2. Steady-state kinetics of reverse reaction (adp formation). Bioorganicheskaya Khimiya, 4 (1), 95−108.
1.1.
1978
Kupriyanov, VV.; Seppet, EK.; Saks, VA. (1978). Creatine-phosphate synthesis coupled with glycolytic reactions in myocardial-cell cytosol. Biochemistry (Moscow), 43 (8), 1153−1161.
1.1.
1977
Saks, V.A.; Seppet, E.K.; Lyulina, N.V. (1977). A comparative study of the role of creatine phosphokinase isoenzymes in energy metabolism of skeletal and heart muscle. Biokhimia, 42 (4), 579−588.
1.1.
1977
Levitsky, D.O.; Levchenko, T.S.; Saks, V.A.; Sharov, V.G.; Smirnov, V.N. (1977). The functional coupling between Ca2+ -ATPase and creatine phosphokinase in heart muscle sarcoplasmic reticulum. Biochimia, 42 (10), 1766−1773.
1.1.
1977
Sharov, V. G.; Saks, V. A.; Smirnov, V. N.; Chazov, E. I. (1977). An electron microscopic histochemical investigation of creatine phosphokinase in heart cells. Biochimica et Biophysica Acta, 468 (3), 495−501.
1.1.
1977
Saks, V. A.; Lipina, N. V.; Sharov, V. G.; Smirnov, V. N.; Chazov, E. I.; Grosse, Richard (1977). The localization of the MM isoenzyme of creatine phosphokinase on the surface membrane of myocardial vells and its functional coupling to analain-inhibited (Na+, K+ ) ATPase. Biochimica et Biophysica Acta, 465 (3), 550−558.
1.1.
1977
Kupriyanov, VV.; Seppet, EK.; Saks, VA. (1977). Adenylate kinase from heart. 1. Kinetics of forward reaction. Bioorganicheskaya Khimiya, 3 (12), 1682−1695.
1.1.
1977
Saks, VA.; Seppet, EK.; Lyulina, NV. (1977). Comparative investigation of role of creatine-phosphokinase isoenzymes in energy-metabolism of skeletal-muscles and myocardium. Biochemistry (Moscow), 42 (4), 445−452.
1.3.
1977
Rosenshtraukh, L.V.; Saks, V.A.; Undrovinas, A.I.; Yuryavichus, A.I.; Yushmanova, A.V.; Sharov, V.G.; Seppet, E.K.; Smirnov, V.N.; Chazov, E.I. (1977). The role of creatine phosphokinase systems in regulation of the force of contraction of frog heart muscle. Fisioliologitšeski Zhurnal SSSR, 63, 681−688.
1.1.
1976
Saks, V. A.; Lipina, N. V.; Smirnov, V. N.; Chazov, E. I. (1976). Studies of energy transport in heart cells. The functional coupling between mitochondrial creatine phosphokinase and ATP-ADP translocase: kinetic evidence. Archives of Biochemistry and Biophysics, 173 (1), 34−41.
1.1.
1976
Saks, V. A.; Chernousova, G. B.; Vetter, R.; Smirnov, V. N.; Chazov, E. I. (1976). Kinetic propenties and the functional role of particulate MM-isoenzyme of creatine phosphokinase bound to heart muscle myofibrilis. FEBS Letters, 62 (3), 293−296.
1.1.
1976
Saks, V.A.; Lipina, N.V.; Chernousova, G.B.; Sharov, V.G.; Smirnov, V.N.; Grosse, R. (1976). Functional coupling of MM isoenzyme of creatine kinase with MgATPase of myofibrils and Na,K-ATPase of plasmatic membrane of heart cells. Biochimia, 41 (12), 2099−2109.
1.1.
1976
Saks, V. A.; Lipina, N.V.; Lyulina, N.V.; Chernousova, G.B.; Vetter, R.; Smirnov, V.N.; Chazov, E.I. (1976). Functional characteristics of creatine kinase reactions in heart mitochondria and myofibrils. Biochimia, 41 (8), 1450−1470.
1.1.
1976
Saks, V. A.; Rosenshtraukh, L. V.; Undrovinas, A. I.; Smirnov, V. N.; Chazov, E. I. (1976). Studies of energy transport in heart cells. Intracellular creatine content as a regulatory factor of frog heart energetics and fonce of contraction. Biochemical Medicine, 16 (1), 21−36.
1.3.
1976
Rosenshtraukh, L.V.; Saks, V.A.; Undrovinas, A.I.; Yushmanova, A.V.; Smirnov, V.N.; Chazov, E.I. (1976). A study of the dependence of the frog heart muscle contractile force àn intracellular energy transport processes. Fisioliologitšeski Zhurnal SSSR, 62, 1199−1210.
1.1.
1975
Saks, V. A.; Chernousova, G. B.; Gukovsky, D. E.; Smirnov, V. N.; Chazov, E. I. (1975). Studies of Energy Transport in heart cells. Mitochondrial isoenzyme of creatine phosphokinase: kinetic properties and regulatort action of Mg 2+ ions. European Journal of Biochemistry, 57 (1), 273−290.
1.3.
1975
Saks, V.A.; Lyulina, N.V.; Chernousova, G.B.; Voronkov, Yu.I.; Smirnov, V.N.; Chazov, E.I. (1975). Study of the role of mitochondrial creatine kinase in the process of energy transport in the heart cells. Kardiologiya, 9, 103−110.
1.1.
1974
Saks, V. A.; Chernousova, G. B.; Voronkov, U. I.; Smirnov, V. N.; Chazov, E. I. (1974). Study of energy transport mechanism in myocardial cells. Circulation Research, 34-35 (Suppl. III), 138−149.
1.3.
1974
Saks, V.A.; Voronkov, Yu.I. (1974). Diagnostic significance of serum creatine kinase activity in myocardial infarction. Terapevticheskii Arkhiv, 6, 32−38.
21.04.2019

Valdur Saks

https://www.etis.ee/CV/Valdur_Saks/eng
3.09.1943
639 8363
644 8643
valdur.saks@ujf-grenoble.fr

Career

Institution(s) and position(s)
Institute of Cybernetics, Academy of Sciences of Estonia, junior research scientist 1970-1971
Moscow University, department of Chemistry, junior research scientist 1971-1972
Moscow Cardiocenter, senior research scientist 1972-1981
Moscow Cardiocenter, head of the laboratory of Bioenergetics 1981-1993
National Institute of Chemical Physis and Biophysics, head of the laboratory of Bioenergetics 1993 until today
Joseph Fourier University, Grenoble, Professor of the laboratory of Physiology of the Heart Cell 1994 until today
University of Pennsylvania, Philadelphia, USA, 1975-1978
John Hopkins University, Baltimore, USA, 1978-1981
Universite Paris-Sud, Orsay, France repeatedly in years 1981-1993
Work in cooperation:
01.01.2015–31.12.2016   
National Institute of Chemical Physics and Biophysics, Senior Research Fellow (0,10)
01.09.2007–31.12.2014   
National Institute of Chemical Physics and Biophysics, leading researcher (0,50)
 
 
Education
higher, Moscow University
 
 
R&D related managerial and administrative work
2010−...   
academic editor of the journal PLoS One
Member of the Academy of Sciences of Estonia 1993
International Society for Heart Research, member of the executive committee
American Heart Association, Basic Science Council
International Federation of Cardiological Societies
Biochemical Society of Russia
American Physiological Society
American Biophysical Society
Participation in editorial board:
Journal of Molecular and Cellular Cardiology, USA
Il Cuore, Italy
Cardioscience, Italy
Journal of Physiology, Poland

Qualifications

Academic degrees
Valdur Saks, Doctor's Degree, 1971, (sup) I. V. Berezin, Oksüdeeriva fosforüleerimise süsteemi stabiliseerimine tema funktsioneerimisel (Stabilisation of the system of oxidative phosphorylation by its functioning), Moskva Ülikool.
 
 
Honours & awards
2008, Valdur Saks, 2008, Yearly Award, Biosciences and Environment; National Science Award
2006, Valdur Saks, The White Star Order 4th Class
 
 
Field of research
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.1. Biochemistry
 
 
Additional information
Candidate in chemistry
Doctor in biology 1971 Moscow University
1981 Moscow Cardiocenter

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2015
Guzun, Rita; Kaambre, Tuuli; Bagur, Rafaela; Grichine, Alexei; Usson, Yves; Varikmaa, Minna; Anmann, Tiia; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Boucher, Francois; Dos Santos, Pierre; Schlattner, Uwe; Wallimann, Theo; Kuznetsov, Andrey; Dzeja, Petras; Aliev, Mayis; Saks, Valdur (2015). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica, 213 (1), 84−106.10.1111/apha.12287.
1.1.
2014
Anmann, Tiia; Varikmaa, Minna; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor, Chekulayev, Vladimir'; Saks, Valdur; Kaambre, Tuuli. (2014). Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochimica et Biophysica Acta - Bioenergetics, 1837 (8), 1350−1361.10.1016/j.bbabio.2014.03.015.
1.1.
2014
Varikmaa, M.; Bagur, R.; Kaambre, T.; Grichine, A.; Timohhina, N.; Tepp, K.; Shevchuk, I.; Chekulayev, V.; Metsis, M.; Boucher, F.; Saks, V.; Kuznetsov, A. V.; Guzun, R. (2014). Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochimica et Biophysica Acta - Bioenergetics, 1837 (2), 232−245.10.1016/j.bbabio.2013.10.011.
1.1.
2014
Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Shevchuk, Igor; Tepp, Kersti; Kaldma, Andrus; Koit, Andre; Saks, Valdur; Kaambre, Tuuli (2014). Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. Journal of Bioenergetics and Biomembranes, 46 (1), 17−31.10.1007/s10863-013-9529-5.
3.1.
2014
Saks, V.; Schlattner, U.;Tokarska-Schlattner, M.; Wallimann, T.; Bagur, R.; Zorman, S.; Pelosse, M.; Dos Santos, P.; Boucher, F; Kaambre, T.; Guzun, R. (2014). Systems Level Regulation of Cardiac Energy Fluxes Via Metabolic Cycles: Role of Creatine,Phosphotransfer Pathways, and AMPK Signaling. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (Ed.). " SYSTEMS BIOLOGY OF METABOLIC AND SIGNALING NETWORKS: ENERGY, MASS AND INFORMATION TRANSFER." (261−320).. Heidelberg: Springer-Verlag Berlin. (Springer Series in Biophysics; 16).10.1007/978-3-642-38505-6_11.
3.1.
2014
Aon, M. A.; Lloyd, D.; Saks, V. (2014). From Physiology, Genomes, Systems, and Self-Organization to Systems Biology: The Historical Roots of a Twenty-First Century Approach to Complexity. In: Aon, Miguel A.; Saks, Valdur; Schlattner, Uwe (_EditorsAbbr). Systems Biology of Metabolic and Signaling Networks (3−17).. Springer-Verlag Heidelberg.10.1007/978-3-642-38505-6_1.
1.1.
2013
Kaambre, Tuuli; Chekulayev, Vladimir; Shevchuk, Igor; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Bagur, Rafaela; Klepinin, Aleksandr; Anmann, Tiia; Koit, Andre; Kaldma, Andrus; Guzun, Rita; Valvere, Vahur; Saks, Valdur (2013). Metabolic Control Analysis of Respiration in Human Cancer Tissue. Frontiers in Physiology, 4, 1−6.10.3389/fphys.2013.00151.
1.1.
2013
Varikmaa, M.; Guzun, R.; Grichine, A.; Gonzalez-Granillo, M;, Usson, Y.: Boucher, F.; Kaambre, T.; Saks, V. (2013). Matters of the heart in bioenergetics: mitochondrial fusion into continuous reticulum is not needed for maximal respiratory activity. Journal of Bioenergetics and Biomembranes, 45 (4), 319−331.10.1007/s10863-012-9494-4.
1.3.
2013
Käämbre, Tuuli; Koit, Andre; Ševtšuk, Igor; Tšekulajev, Vladimir; Tepp, Kersti; Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur (2013). Uusi suundi kasvajate energiametabolismi uuringutes. Eesti Arst, 92 (5), 261−267.
1.3.
2013
Anmann, Tiia; Varikmaa, Minna; Tepp, Kersti; Timohhina, Natalja; Ševtšuk, Igor; Tšekulajev, Vladimir; Saks, Valdur; Käämbre, Tuuli (2013). Südamerakkude sünnijärgse arengu bioenergeetilised aspektid: struktuuri ja funktsiooni vaheliste seoste väljakujunemine [Bioenergetic aspects of postnatal development of cardiac cells: formation of structure-function relationship]. Eesti Arst, 92 (7), 372−381.
3.5.
2013
Käämbre, T., Ševtšuk, I., Saks, V. (2013). Süsteemibioloogia ja süsteemibioenergeetika: kuidas uurida struktuuri ja funktsiooni vahelisi seoseid. Teoreetilise bioloogia kevadkool: 39. Teoreetilise bioloogia kevadkool, Mustjõe, Aegviidu. Toim. Sõber, Virve; Laanisto, Lauri; Öpik, Maarja; Tammaru, Toomas; Kull, Kalevi. Tartu: Eesti Looduseuurijate Selts, 29−40. (Schola Biotheoretica; 39).
3.5.
2013
Varikmaa, M; Bagur, R; Metsis, M; Grichine, A; Tepp, K; Käämbre, T; Saks, V and Guzun, R. (2013). Fine-tuning mitochondria function by betaII tubulin in striated muscles. Barcelona BioMed Conference "The microtubule cytoskeleton in development and disease"..
5.1.
2013
Quetglas, RB; Karu-Varikmaa, M; Tepp, K; Metsis, M; Kaambre, T; Grichine, A; Boucher, F; Saks, V; Guzun, R (2013). Regulation of Respiration in Permeabilized Muscle Cells: Apparent KM for ADP Shows the Mitochondrial Outer Membrane Permeability. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. 447A−448A. (2; 1).
5.1.
2013
Karu, M ; Bagun, R ; Metsis, M ; Grichine, A; Tepp, K ; Kaambre, T; Saks, V; Guzun, R (2013). Unpolymerized beta II Tubulin in Regulation of Mitocondrial Function in Muscle Cells. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. 302A−302A. (2; 1).
5.1.
2013
Koit, Andre; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Bogovskaja, Jelena; Valvere, Vahur Saks, Valdur; Kaambre, Tuuli (2013). Bioenergetic profiling of human breast cancer: unusual organisation of the respiratory chain. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 922.10.1016/j.mito.2013.07.064.
5.1.
2013
Kaldma, Andrus; Koit, Andre; Shevchuk, Igor; Chekulayev, Vladimir; Tepp, Kersti; Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur; Kaambre, Tuuli (2013). Regulation of respiration of human colorectal cancer: application of Metabolic Control Analysis. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 900.
5.1.
2013
Shevchuk, Igor; Koit, Andre; Kaldma, Andrus; Timohhina, Natalja; Chekulayev, Vladimir; Tepp, Kersti; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur; Kaambre, Tuuli (2013). Comparative aspects of bioenergetic profiling of tumor clinical material and cell cultures. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 907.10.1016/j.mito.2013.07.027.
1.1.
2012
Guzun, R.; Aguilaniu, B.; Wuyam, B.; Mezin, P.; Koechlin-Ramonatxo, C.; Auffray, C.; Saks, V.; Pison, C. (2012). Effects of training at mild exercise intensities on quadriceps muscle energy metabolism in patients with chronic obstructive pulmonary disease. Acta Physiologica, 205 (2), 236−246.10.1111/j.1748-1716.2011.02388.x.
1.1.
2012
Tokarska-Schlattner, M., Epand, R.F., Meiler, F et al.. (2012). Phosphocreatine interacts with phospholipids, affects membrane properties and exerts membrane-protective effects. PLoS ONE, 7, e43178.
1.1.
2012
Kuznetsov, A.V.; Guzun, R.; Boucher, F.; Bagur, R.; Käämbre, T.; Saks, V. (2012). Mysterious Ca2+-independent muscular contraction: deja vu. Biochemical Journal, 445, 333−336.DOI:BJ20120439[pii]10.1042/BJ20120439.
1.1.
2012
Käämbre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Tepp, K.; Bogovskaja, J.; Kütner, R.; Valvere, V.; Saks, V. (2012). Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. Journal of Bioenergetics and Biomembranes, 44 (5), 539−558.DOI:10.1007/s10863-012-9457-9.
1.1.
2012
Guzun, R.; Gonzalez-Granillo, M.; Karu-Varikmaa, M.; Grichine, A.; Usson, Y.; Käämbre, T.; Guerrero-Roesch, K.; Kuznetsov, A.; Schlattner, U.; Saks, V. (2012). Regulation of respiration in muscle cells in vivo by VDAC through interaction with the cytoskeleton and MtCK within Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1818, 1545−1554.DOI:10.1016/j.bbamem.2011.12.034.
1.1.
2012
Gonzalez-Granillo, M.; Grichine, A.; Guzun, R.; Ussov, Y.; Tepp, K.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Kuznetsov, A.V.; Grimm, M.; Saks, V.; Käämbre, T. (2012). Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. Journal of Molecular and Cellular Cardiology, 52, 437−447.DOI:10.1016/j.yjmcc.2011.07.027.
1.1.
2012
Saks, V.; Kuznetsov, A.V.; Gonzalez-Granillo, M.; Tepp, K.; Timohhina, N.; Karu-Varikmaa, M.; Käämbre, T.; Santos, P.D.; Boucher, F.; Guzun, R. (2012). Intracellular energetic Units regulate metabolism in cardiac cells. Journal of Molecular and Cellular Cardiology, 419−436.DOI:10.1016/j.yjmcc.2011.07.015.
5.1.
2012
Tepp, K.; Kaambre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Valvere, V.; Saks, V. (2012). Comparative investigation of bioenergetic properties of human colorectal and breast cancer. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S136. (supplement to volume 1817).
5.1.
2012
Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Tepp, K.; Klepinin, A.; Saks, V.; Kaambre, T. (2012). Metabolic control analysis of integrated energy metabolism in permeabilized neuroblastoma cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S135. (supplement for volume 1817).
5.2.
2012
Timohhina, N.; Anmann, T.; Klepinin, A.; Tepp, K.; Shevchuk, I.; Käämbre, T.; Saks, V. (2012). Postnatal developments of rat heart: formation of intracellular energetic units. In New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. June 12-15, 2012; Hradec Kralove, Czech Republic, Hradec Kralove. 40−40.
5.2.
2012
Tepp, K.; Timohhina, N.; Chekulayev, V.; Saks, V.; Kaambre, T.; Shevchuk, I. (2012). Control Analysis of Intracellular Energetic Unit in cardiac cell. In New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. June 12-15, 2012; Hradec Kralove, Czech Republic, Hradec Kralove. 39−39.
5.2.
2012
Klepinin, A.; Karu-Varikmaa, M.; Shevchuk, I.; Chekulayev, V.; Tepp, K.; Saks, V. and Käämbre, T. (2012). Intracellular energetic units organized by tubulin. New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. Hradec Kralove, Czech Republic, Hradec Kralove, June 12-15, 2012. 39-40−40.
1.1.
2011
Aliev, M., Guzun, R., Karu-Varikmaa, M., Kaambre, T., Wallimann, T., Saks, V. (2011). Molecular system bioenergics of the heart: experimental studies of metabolic compartmentation and energy fluxes versus computer modeling. International Journal of Molecular Sciences, 12 (12), 9296−9331.10.3390/ijms12129296.
1.1.
2011
Kuznetsov, A.V.; Margreiter, R.; Amberger, A.; Saks, V.; Grimm, M. (2011). Changes in mitochondrial dysfunction in doxorubicin-induced cell death. Biochimica et Biophysica Acta, 1813 (6), 1144−1152.
1.1.
2011
Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Kuznetsov, A.V.; Guzun, R.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochimica et Biophysica Acta, 1807 (12), 1549−1561.
1.1.
2011
Guzun, R.; Timohhina, N.; Tepp, K.; Gonzalez-Granillo, M.; Shevchuk, I.; Chekulayev, V.; Kuznetsov, A.V.; Käämbre, T.; Saks, V.A. (2011). Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function. Amino Acids, 40, 1333−1348.
1.1.
2011
Guzun, R.; Karu-Varikmaa, M.; Granillo, M.G.; Kuznetsov, A.V.; Michel, L.; Cottet-Rousselle, C.; Saaremäe, M.; Käämbre, T.; Metsis, M.; Grimm, M.; Auffray, C.; Saks, V. (2011). Mitochondria-cytoskeleton interaction: Distribution of β-tubulins in cardiomyocytes and HL-1 cells. Biochimica et Biophysica Acta, 1807 (4), 458−469.
5.1.
2011
Karu-Varikmaa, M.; Metsis, M.; Guzun, R.; Käämbre, T.; Grichine, A.; Saks, V. (2011). Investigation of interactions between mitochondrial creatine kinase and ATP/ADP channel. FEBS Journal, 278, 374−375.
5.1.
2011
Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux control with mitochondrial interactosome in cardiac cell. FEBS Journal, 278, 377−377.
5.1.
2011
Saks, V.; Aliev, M.; Tepp, K.; Karu-Varikmaa, M.; Chekulaev, V.; Shevchuk, I.; Käämbre, T.; Guzun, R. (2011). Quantitative Analysis of Integrated Energy Metabolism of Muscle Cells: Experimental and Theoretical Studies. Biophysical Journal, 100, 2a−2a.
5.2.
2011
Gonzalez-Granillo, M.A.; Karu-Varikmaa, M.; Saaremäe, M.; Michel, L.; Käämbre, T.; Saks, V.; Guzun, R. (2011). Mitochondrial Interactosome in Energy Metabolism in Healthy and Cancer Cells. Biophysical Journal, 100, 298a−298a.
5.2.
2011
Karu-Varikmaa, M.; Saaremäe, M.; Sikk, P.; Käämbre, T.; Metsis, M.; Saks, V. (2011). Regulation of Mitochondrial Respiration by Different Tubulin Isoforms in Vivo. Biophysical Journal, 100, 459a−459a.
1.1.
2010
Tepp, Kersti; Timohhina, Natalya; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes - experimental study. Acta Biochimica Polonica, 57 (4), 421−430.
1.1.
2010
Guzun, R.; Saks, V. (2010). Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo. International Journal of Molecular Sciences, 11, 982−1019.
1.1.
2010
Tokarska-Schlattner, M.; Lucchinetti, E.; Zaugg, M.; Kay, L.; Gratia, S.; Guzun, R.; Saks, VA.; Schlattner, U. (2010). Early effects of doxorubicin in perfused heart: transcriptional profiling reveals inhibition of cellular stress response genes. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 298 (4), R1075−R1088.10.1152/ajpregu.00360.2009.
1.1.
2010
Saks, Valdur; Guzun, Rita; Timohhina, Natalja; Tepp, Kersti; Varikmaa, Minna; Monge, Claire; Beraud, Nathalie; Käämbre, Tuuli; Kuznetsov, Andrey; Kadaja, Lumme; Eimre, Margus; Seppet, Enn. (2010). Structure–function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1797, 678−697.
1.1.
2010
Guerrero, K.; Monge, C.; Brückner, A.; Puurand, U.; Kadaja, L.; Käämbre, T.; Seppet, E.; Saks, V. (2010). Study of possible interactions of tubulin, microtubular network, and STOP protein with mitochondria in muscle cells. Molecular and Cellular Biochemistry, 337, 239−249.10.1007/s11010-009-0304-1.
3.1.
2010
Monge, Claire; Guzun, Rita; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Sikk, Peeter; Käämbre, Tuuli; Saks, Valdur (2010). Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells. In: Oliver L. Svensson (Ed.). Mitochondria: Structure, Functions and Dysfunctions (441−470).. Nova Science Publisher Inc..
5.1.
2010
Varikmaa, Minna; Metsis, Madis; Guzun, Rita; Käämbre, Tuuli; Grichine, Alexei; Saks, Valdur (2010). Novel Method for Investigation of Interactions between Mitochondrial Creatine Kinase and Adenine Nucleotide Translocase. Biophysical Journal, 98: Biophysical Society 54th Annual Meeting, February 20-24 , San Fransisco. 2010, 735a. (3).
5.1.
2010
Saks, V.; Guzun, R.; Timohhina, N.; Tepp, K.; Varikmaa, M.; Monge, C.; Beraud, N.; Kaambre, T.; Kuznetsov, A.; Kadaja, L.; Margus, E.; Seppet, E. (2010). Systems biology and bioenergetics: Structure-function relationships in feedback regulation of energy fluxes in vivo Mitochondrial interactosome. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−138. (Supplement 1).
5.1.
2010
Tepp, Kersti; Timohhina, Natalja; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−139. (Supplement 1).
1.1.
2009
Saks, V. (2009). Molecular System Bioenergetics-New Aspects of Metabolic Research. International Journal of Molecular Sciences, 10 (8), 3655−3657.
1.1.
2009
Kuznetsov, A.V.; Hermann, M.; Saks, V.; Hengster, P.; Margreiter, R. (2009). The cell-type specificity of mitochondrial dynamics. International Journal of Biochemistry & Cell Biology, 41 (10), 1928−1939.
1.1.
2009
Beraud, Nathalie; Pelloux, Sophie; Usson, Yves; Kuznetsov, Andrey V.; Ronot, Xavier; Tourneur, Yves; Saks, Valdur (2009). Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non beating Hl-1 cells. Journal of Bioenergetics and Biomembranes, 41 (2), 195−214.10.1007/s10863-009-9214-x.
1.1.
2009
Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.
1.1.
2009
Guzun, R.; Timohhina, N.; Tepp, K.; Monge, C.; Käämbre, T.; Sikk, P.; Kuznetsov, AV.; Pison, C.; Saks, V. (2009). Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ importance of system level properties. Biochimica et Biophysica Acta - Bioenergetics, 1787 (9), 1089−1105.10.1016/j.bbabio.2009.03.024.
1.1.
2009
Monge, Claire; Beraud, Nathalie; Tepp, Kersti; Pelloux, Sophie; Chahboun, Siham; Käämbre, Tuuli; Kadaja, Lumme; Roosimaa, Mart; Piirsoo, Andres; Tourneur, Yves; Kuznetsov, Andrey V; Saks, Valdur; Seppet, Enn (2009). Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Canadian Journal of Physiology and Pharmacology, 87 (4), 318−326.
1.1.
2009
Saks, Valdur; Monge, Claire; Guzun, Rita (2009). Philosophical Basis and Some Historical Aspects of Systems Biology: From Hegel to Noble - Applications for Bioenergetic Research. International Journal of Molecular Sciences, 10, 1161−1192.
1.1.
2009
Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu; Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.
5.2.
2009
Beraud, Nathalie; Pelloux, Sophie; Usson, Yves; Kuznetsov, Andrey V.; Ronot, Xavier; Tourneur, Yves; Saks, Valdur (2009). Mitochondrial dynamics in heart cells: very low amplitude high frequency fluctuations in adult cardiomyocytes and flow motion in non-beating Hl-1 cells. Biophysical Journal, 96, 243a.10.1016/j.bpj.2008.12.1197.
6.7.
2009
Saks, Valdur; Engelbrecht, Jüri; Seppet, Enn; Vendelin, Marko (2009). Molekulaarne süsteemne bioenergeetika : kommentaar Eesti Vabariigi teaduse aastapreemia pälvinud tööde tsüklile. Mägi, Vahur (_EditorsAbbr). Tallinna Tehnikaülikooli aastaraamat 2008. XVI (291−298).. Tallinn: TTÜ kirjastus.
1.1.
2008
Rostovtseva, Tatiana K.; Sheldon, Kely L.; Hassanzadeh, Elnaz; Monge, Claire; Saks, Valdur; Bezrukov, Sergey M.; Sackett, Dan L. (2008). Tubulin binding blocks mitochondrial voltage-dependent anion channel and regulates respiration. Proceedings of the National Academy of Sciences of the United States of America, 105 (48), 18746−18751.
1.1.
2008
Kuznetsov, A.V.; Veksler, V.; Gellerich, F.N.; Saks, V.; Margreiter, R.; Kunz, W.S. (2008). Analysis of mitochondrial function in situ in permeabilized muscle fibers, tissues and cells. Nature Protocols, 3 (6), 965−976.
1.1.
2008
Saks, V. (2008). The phosphocreatine-creatine kinase system helps to shape muscle cells and keep them healthy and alive. Journal of Physiology-London, 586 (12), 2817−2818.
1.1.
2008
Monge, C.; Beraud, N.; Kuznetsov, A.V.; Rostovtseva, T.; Sackett, D.; Schlattner, U.; Vendelin, M.; Saks, V.A. (2008). Regulation of respiration in brain mitochondria and synaptosomes: restrictions of ADP diffusion insitu, roles of tubulin, and mitochondrial creatine kinase. Molecular and Cellular Biochemistry, 318, 147−165.10.1007/s11010-008-9865-7.
1.1.
2008
Saks, V.; Beraud, N.; Wallimann, T. (2008). Metabolic compartmentation - A system level property of muscle cells. International Journal of Molecular Sciences, 9 (5), 751−767.
1.1.
2008
Eimre, M.; Paju, K.; Pelloux, S.; Beraud, N.; Roosimaa, M.; Kadaja, L.; Gruno, M.; Peet, N.; Orlova, E.; Remmelkoor, R.; Piirsoo, A.; Saks, V.; Seppet, E. (2008). Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes. Biochimica et Biophysica Acta - Bioenergetics, 1777 (6), 514−524.
1.3.
2008
Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Tiivel, Toomas; Timohhina, Natalja; Nutt, Anu; Tepp, Kersti; Saks, Valdur (2008). Südamelihase rakkude struktuuri olulisusest rakuhingamise regulatsioonis. Eesti Arst, 1, 19−22.
5.1.
2008
Seppet, E.; Paju, K.; Roosimaa, M.; Kadaja, L.; Peet, N.; Eimre, M.; Orlova, E.; Saks, V. (2008). Distinct organization of energy metabolism in HL-1 cardiac cells and cardiomyocytes. Journal of Molecular and Cellular Cardiology, 44 (4), 780−781.10.1016/j.yjmcc.2008.02.166.
5.2.
2008
Guzun, Rita; Timokhina, Nathalia; Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Saks, Valdur (2008). DIFFERENT STEADY STATE KINETICS OF REGULATION OF MtCK – DEPENDENT RESPIRATION IN ISOLATED MITOCHONDRIA AND PERMEABILIZED CARDIAC CELL in situ. Biophysical Society 52nd Annual Meeting & 16th International Biophysics Congress February 2-6, 2008 Long Beach, California.
5.2.
2008
Seppet, Enn; Saks, Valdur (2008). Structure-function relationships in organization of energy metabolism in cardiac cells. Experimental and Clinical Cardiology, 13: Mendel Symposium II: genes and the Heart, Joint Meeting of the japan and European sections of the International Academy of cardiovascular Sciences; Leblice, Czech Republic; September 24 to 27. _EditorsAbbr Ostadal, B. Canada: Pulsus Group Inc, 151−151.
5.2.
2008
Seppet, E.; Paju, K.; Roosimaa, M.; Kadaja, L.; Peet, N.; Eimre, M.; Orlova, E.; Saks, V. (2008). Distinct organization of energy metabolism in different types of cardiac cells. NATO Advanced Research Workshop on Translational Knowledge for Heart Research; Istanbul, Turkey; 12-16 May 2008.
6.7.
2008
[Saks, Valdur; Engelbrecht, Jüri; Seppet, Enn; Vendelin, Marko] (2008). Teaduspreemia geo-ja bioteaduste alal tööde tsükli "Molekulaarne süsteemne bioenergeetia" eest. Villems,Richard (_EditorsAbbr). Eesti Vabariigi teaduspreemiad 2008 (110−123).. Tallinn: Eesti Teaduste Akadeemia.
3.1.
2007
Saks, V. (2007). From the discovery of oxygen to molecular system bioenergetics. In: V.Saks (_EditorsAbbr). MOLECULAR SYSTEM BIOENERGETICS./ ENERGY FOR LIFE (x).. Manheim: Wiley-VCH.
3.1.
2007
Saks, Valdur; Dzeja, Petras P.; Guzun, Rita; Aliev, Mayis K.; Vendelin, Marko; Terzic, André; Wallimann, Theo (2007). System analysis of cardiac energetics - excitation-contraction coupling: integration of mitochondrial respiration, phosphotransfer pathways, metabolic pacing and substrate supply in the heart. In: Saks, Valdur (_EditorsAbbr). Molecular system bioenergetics: energy for life (367−406).. Weinheim: Wiley-VCH.10.1002/9783527621095.ch11.
3.1.
2007
Saks, V.; Monge, C.; Anmann, T.; Dzeja, P. (2007). Integrated and organized cellular energetic systems: theories of cell energetics, compartmentation and metabolic channeling. In: V.Saks (_EditorsAbbr). MOLECULAR SYSTEM BIOENERGETICS./ ENERGY FOR LIFE (59−97).. Manheim: Wiley-VCH.
3.1.
2007
Saks, V.; Kaambre, T.; Guzun, R.; Anmann, T.; Sikk, P.; Schlattner, U.; Wallimann, T.; Aliev, M.; Vendelin, M. (2007). The creatine kinase phosphotransfer network: thermodynamic and kinetic considerations, the impact of the mitochondrial outer membrane and modelling approaches. In: Salomons, G.S.; Wyss, M. (Ed.). Creatine and Creatine Kinase in Health and Disease (27−65).. Dordrecht: Springer. (Subcellular Biochemistry; 46).10.1007/978-1-4020-6486-9_3.
3.1.
2007
Vendelin, Marko; Saks, Valdur; Engelbrecht, Jüri (2007). Principles of mathematical modeling and in silico studies of integrated cellular energetics. In: Saks,Valdur (_EditorsAbbr). Molecular system bioenergetics: energy for life (407−433).. Weinheim: Wiley-VCH.10.1002/9783527621095.ch12.
3.1.
2007
Saks, V.A.; Vendelin, M.; Aliev, M.K.; Kekelidze, T.; Engelbrecht, J. (2007). Mechanisms and modeling of energy transfer between intracellular compartments. In: Lajtha, A.; Gibson, G. E.; Dienel, G. A. (_EditorsAbbr). Handbook of Neurochemistry and Molecular Neurobiology : Brain Energetics. Integration of Molecular and Cellular Processes (815−860).. New York: Springer. (8.1).10.1007/978-0-387-30411-3_30.
4.1.
2007
Saks, Valdur (Editor) (2007). Molecular System Bioenergetics: Energy for Life. Manheim: Wiley-VCH.
5.1.
2007
Saks, V.A.; Vendelin, M.; Aliev, M.; Monge, C.; Engelbrecht, J. (2007). Molecular system bioenergetics: Mechanisms and modelling of energy transfer between intracellular compartments. Journal of Neurochemistry, 102, 16.
5.1.
2007
Vendelin, M.; Anmann, T.; Kaambre, T.; Sikk, P.; Saks, V. (2007). Modeling of the coupled enzyme systems: model of mitochondrial creatine kinase (miCK) and adenine nucleotide translocase (ANT) coupling. Biophysical Journal, Suppl S, 660A.
5.1.
2007
Anmann, T., Monge, C., Bemud, N., Pelloux, S., Toumeur, Y., Saks, V. (2007). Coupled creatine kinase systems in cardiac cells and synaptosomes: a comparative kinetic study. Biophysical Society Meeting Abstracts: 51st Annual Meeting of the Biophysical-Society, Baltimore, MD, MAR 03-07, 2007. BioPhysical Society, 621A. (Biophysical Journal Supplement).
1.1.
2006
Anmann, T.; Guzun, R.; Beraud, N.; Pelloux, S.; Kuznetsov, A.V.; Kogerman, L.; Kaambre, T.; Sikk, P.; Paju, K.; Peet, N.; Seppet, E.; Ojeda, C.; Tourneur, Y.; Saks, V. (2006). Different kinetics of the regulation of respiration in permeabilized cardiomyocytes and in HL-1 cardiac cells - Importance of cell structure/organization for respiration regulation. Biochimica et Biophysica Acta - Bioenergetics, 1757 (12), 1597−1606 .10.1016/j.bbabio.2006.09.008.
1.1.
2006
Saks, Valdur; Dzeja, Petras; Schlattner, Uwe; Vendelin, Marko; Terzic, Andre; Wallimann, Theo (2006). Cardiac system bioenergetics: metabolic basis of the Frank-Starling law. The Journal of Physiology, 571 (2), 253−273.
1.1.
2006
Eimre, M.; Puhke, R.; Alev, K.; Seppet, E.; Sikkut, A.; Peet, N.; Kadaja, L.; Lenzner, A.; Haviko, T.; Seene, T.; Saks, V.A.; Seppet, E.K. (2006). Altered mitochondrial apparent affinity for ADP and impaired function of mitochondrial creatine kinase in gluteus medius of patients with hip osteoarthritis. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 290 (5), R1271−R1275.
1.1.
2006
Pelloux, S.; Robillard, J.; Ferrera, R.; Bilbaut, A.; Ojeda, C.; Saks, V.; Ovize, M.; Tourneur, Y. (2006). Non beating HL-1 cells for confocal microscopy. Application to mitochondrial functions during cardiac preconditioning. Progress in Biophysics and Molecular Biology, 90, 270−298.
1.2.
2006
Seppet, E.K.; Eimre, M.; Anmann, T.; Seppet, E.; Piirsoo, A.; Peet, N.; Paju, K.; Guzun, R.; Beraud, N.; Pelloux, S.; Tourneur, Y.; Kuznetsov, A.V.; Käämbre, T.; Sikk, P.; Saks, V.A. (2006). Structure-function relationships in regulation of the energy transfer between mitochondria and ATPases in cardiac cells. Experimental and Clinical Cardiology, 11 (3), 189−194.
3.1.
2006
Saks, V.; Guerrero, K.; Vendelin, M.; Engelbrecht, J.; Seppet, E. (2006). The creatine kinase isoenzymes in organized metabolic networks and regulation of cellular respiration: a new role for Maxwell's demon. In: Vial, C. (_EditorsAbbr). Creatine Kinase (223−267).. New York: Nova Science Publishers. (Molecular Anatomy and Physiology of Proteins).
3.2.
2006
Saks, V.; Aliev, M.; Guzun, R.; Beraud, N.; Monge, C.; Anmann, T.; Kuznetsov, A.; Seppet, E. (2006). Biophysics of the organized metabolic networks in muscle and brain cells. In: Pandalai, S.G. (_EditorsAbbr). Recent Research Developments in Biophysics (269−318).. Kerala, India: Transworld Research Networks.
5.1.
2006
Seppet, E.K.; Eimre, M.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Kaambre, T.; Saks, VA. (2006). Calcium-induced contraction of sarcomeres changes the interaction between mitochondria and ATPases in permeabilized cardiac cells. Journal of Molecular and Cellular Cardiology, 40 (6), 931−931.
5.1.
2006
Beraud, N.; Pelloux, S.; Kuznetsov, A.; Guzun, R.; Anmann, T.; Tourneur, Y.; Ojeda, C.; Saks, V. (2006). Comparative bioeneregetics of isolated cardiomyocytes and HL-1 cells: Mitochondrial dynamics, respiration regulation and creatine kinase expression. 514−515.
5.2.
2006
Eimre, M.; Seppet, E.; Paju, K.; Orlova, E.; Piirsoo, A.; Sikk, P.; Käämbre, T.; Saks, V. (2006). Kaltsiumist põhjustatud sarkomeeride kontraktsioon muudab mitokondrite ja ATPaaside vahelist interaktsiooni permeabiliseeritud südamerakkudes. 85. 645−646.
1.1.
2005
Guerrero, Karen; Wuyam, Bernard; Mezin, Paulette; Vivodtzev, Isabelle; Vendelin, Marko; Borel, Jean Christian; Hacini, Rachid; Chavanon, Olivier; Imbeaud, Sandrine; Saks, Valdur; Pison, Christophe (2005). Functional coupling of adenine nucleotide translocase and mitochondrial creatine kinase is enhanced after exercise training in lung transplant skeletal muscle. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 289 (4), R1144−R1154.
1.1.
2005
Vendelin, Marko; Beraud, Nathalie; Guerrero, Karen; Andrienko, Tatiana; Kuznetsov, Andrey V.; Olivares, Jose; Kay, Laurence; Saks, Valdur A. (2005). Mitochondrial regular arrangement in muscle cells: a "crystal-like" pattern. American Journal of Physiology - Cell Physiology, 288 (3), C757−C767.
1.1.
2005
Saks, V.A.; Wallimann, T.; Schlattner, U. (2005). Calcium and energy transfer. Journal of Physiology-London, 565 (2), 703−703.
1.1.
2005
Peltier, S.; Burelle, Y.; Novel-Chate, V.; Demaison, L.; Verdys, M.; Saks, V.; Keriel, C.; Leverve, XM. (2005). Effect of exogenous adenosine and monensin on glycolytic flux in isolated perfused normoxic rat hearts: Role of pyruvate kinase. Molecular and Cellular Biochemistry, 277, 55−61.
1.1.
2005
Anmann, T.; Eimre, M.; Kuznetsov, AV.; Andrienko, T.; Kaambre, T.; Sikk, P.; Seppet, E.; Tiivel, T.; Vendelin, M.; Seppet, E.; Saks, VA. (2005). Calcium-induced contraction of sarcomeres changes the regulation of mitochondrial respiration in permeabilized cardiac cells. FEBS Journal, 272 (12), 3145−3161.10.1111/j.1742-4658.2005.04734.x.
1.1.
2005
Seppet, E.; Eimre, M.; Peet, N.; Paju, K.; Orlova, E.; Ress, M.; Kovask, S.; Piirsoo, A.; Saks, VA.; Gellerich, FN.; Zierz, S.; Seppet, EK. (2005). Compartmentation of energy metabolism in atrial myocardium of patients undergoing cardiac surgery. Molecular and Cellular Biochemistry, 270, 49−61.
1.1.
2005
Seppet, E. K.; Eimre, M.; Anmann, T.; Seppet, E.; Peet, N.; Käämbre, T.; Paju, K.; Piirsoo, A.; Kuznetsov, A. V.; Vendelin, M.; Gellerich, F. N.; Zierz, S.; Saks, V. A. (2005). Intracellular energetic units in healthy and diseased hearts. Experimental and Clinical Cardiology, 10 (3), 173−183.
5.1.
2005
Kuznetsov, AV.; Kaambre, T.; Sikk, P.; Saks, V. (2005). Ca2+ and regulation of mitochondrial respiration: Functional and confocal imaging studies. 23, Suppl 2. 8−8.
1.1.
2004
Saks, V.; Kuznetsov, A.V.; Vendelin, M.; Guerrero, K.; Kay, L.; Seppet, E.K. (2004). Functional coupling as a basic mechanism of feedback regulation of cardiac energy metabolism. Molecular and Cellular Biochemistry, 256/257, 185−199.10.1023/B:MCBI.0000009868.92189.fb.
1.1.
2004
Vendelin, Marko; Eimre, Margus; Seppet, Evelin; Peet, Nadezda; Andrienko, Tatiana; Lemba, Maris; Engelbrecht, Jüri; Seppet, Enn K.; Saks, Valdur A. (2004). Intracellular diffusion of adenosine phosphates is locally restricted in cardiac muscle. Molecular and Cellular Biochemistry, 256, 229−241.10.1023/B:MCBI.0000009871.04141.64.
1.1.
2004
Vendelin, Marko; Lemba, Maris; Saks, Valdur A. (2004). Analysis of functional coupling: Mitochondrial creatine kinase and adenine nucleotide translocase. Biophysical Journal, 87 (1), 696−713.
1.1.
2004
Ovadi, J.; Saks, V. (2004). On the origin of intracellular compartmentation and organized metabolic systems. Molecular and Cellular Biochemistry, 5−12.
1.1.
2004
Ojeda, C.; Joseph, P.; Saks, V. A.; Piriou, V.; Tourneur, Y. (2004). Subcellular heterogeneity in mitochondrial red-ox responses to KATP channel agonists in freshly isolated rabbit cardiomyocytes. Molecular and Cellular Biochemistry, 367−377.
1.1.
2004
Kuznetsov, A. V.; Schneeberger, S.; Seiler, R.; Brandacher, G.; Mark, W.; Steurer, W.; Saks, V.; Usson, Y.; Margreiter, R.; Gnaiger, E. (2004). Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. American Journal of Physiology - Heart and Circulatory Physiology, 286 (5), H1633−H1641.
1.1.
2004
Kuznetsov, A. V.; Schneeberger, S.; Renz, O.; Meusburger, H.; Saks, V.; Usson, Y.; Margreiter, R. (2004). Functional heterogeneity of mitochondria after cardiac cold ischemia and reperfusion revealed by confocal imaging. Transplantation, 77, 754−756.
1.1.
2004
Kulp, M.; Kaljurand, M.; Kaambre, T.; Sikk, P.; Saks, V (2004). In situ monitoring of kinetics of metabolic conversion of ATP to ADP catalyzed by mgatpases of muscle Gastrocnemius skinned fibers using micellar electrokinetic chromatography. Electrophoresis, 25 (17), 2996−3002.
1.1.
2004
Seppet, EK.; Eimre, M.; Andrienko, T.; Kaambre, T.; Sikk, P.; Kuznetsov, AV.; Saks, V. (2004). Studies of mitochondrial respiration in muscle cells in situ: Use and misuse of experimental evidence in mathematical modelling. Molecular and Cellular Biochemistry, 256, 219−227.
5.1.
2004
Vendelin, Marko; Lemba, Maris; Saks, Valdur A. (2004). Analysis of functional coupling: Mitochondrial creatine kinase and adenine nucleotide translocase. Biochimica et Biophysica Acta - Bioenergetics, 1658, 198.
5.1.
2004
Vendelin, M.; Guerrero, K.; Andrienko, T.; Saks, V. (2004). Intracellular restrictions of diffusion and metabolic channeling of ADP in cardiac muscle cells. Biophysical Journal, 86 (1), 336A, Part 2 Suppl. S, JAN 2004.
5.1.
2004
Saks, V.; Andrienko, T.; Kuznetsov, A.; Zorov, D; Käämbre, T.; Sikk, P. (2004). Ca2+ contraction and mitochondria in heart: A mechanochemical link? 86. 336A−337A.
5.1.
2004
Seppet, E.; Eimre, M.; Peet, N.; Paju, K.; Ress, M.; Kovask, S.; Saks, VA.; Gellerich, FN.; Zierz, S.; Seppet, EK. (2004). Intracellular energetic units in diseased human atrial myocardium. Journal of Molecular and Cellular Cardiology, 36 (5), 758−758.
1.1.
2003
Aliev, MK.; Saks, VA. (2003). Analysis of the mechanism of functioning of mitochondrial adenine nucleotide translocase using mathematical models. Biofizika, 48 (6), 1075−1085.
1.1.
2003
Vendelin, M.; Bovendeerd, P.H.M.; Saks, V.; Engelbrecht, J.; Arts, T. (2003). Simulating cardiac mechanoenergetics in the left ventricle. Functional Imaging and Modeling of The Heart, Proceedings. 72−80. (Lecture Notes in Computer Science).
1.1.
2003
Andrienko, T.; Kuznetsov, A.V.;Kaambre, T.; Usson, Y.; Orosco, A.; Appaix, F.; Tiivel, T.; Sikk, P.; Vendelin, M.; Margreiter, R.; Saks, V.A. (2003). Metabolic consequences of functional complexes of mitochondria, myofibrils and sarcoplasmic reticulum in muscle cells. The Journal of Experimental Biology, 206 (12), 2059−2072.
1.1.
2003
Saks, Valdur; Kuznetsov, Andrey; Andrienko, Tatiana; Usson, Yves; Appaix, Florence; Guerrero, Karen; Kaambre, Tuuli; Sikk, Peeter; Lemba, Maris; Vendelin, Marko (2003). Heterogeneity of ADP diffusion and regulation of respiration in cardiac cells. Biophysical Journal, 84 (5), 3436−3456.10.1016/S0006-3495(03)70065-4.
1.1.
2003
Kuznetsov, A.V.; Kunz, W. S.; Saks, V.; Usson, Y.; Mazat, J. P.; Letellier, T.; Gellerich, F. N.; Margreiter, R. (2003). Cryopreservation of mitochondria and mitochondrial function in cardiac and skeletal muscle fibers. Analytical Biochemistry, 319 (2), 296−303.
1.1.
2003
Appaix, F.; Kuznetsov, A. V.; Usson, Y.; Kay, L.; Andrienko, T.; Olivares, J.; Kaambre, T.; Sikk, P.; Margreiter, R.; Saks, V. (2003). Possible role of cytoskeleton in intracellular arrangement and regulation of mitochondria. Experimental Physiology, 88, 175−190.10.1113/eph8802511.
3.1.
2003
Seppet, E.; Peet, N.; Paju, K.; Ress, M.; Saks, V.; Gellerich, FN; Chen, Y.; Trumbeckaite, S.; Prondzinsky, R; Silber, R.; Werdan, K; Zierz, S.; Seppet, E. (2003). Mitochondrial function in failing human myocardium in vivo: atrioventricular differences. In: Singal P.K.; Dixon, I.M.C.; Kirshenbaum, L.A.; Dhalla, N.S. (Ed.). Cardiac Remodeling and Failure (459−470).. Dodrecht: Kluwer Academic Publishers. (Progress in Experimental Cardiology; 5).
3.1.
2003
Saks, V.A.; Kay, L.; Appaix, F.; Andrienko, T.; Seppet, E. (2003). Creatine kinase and brain energy metabolism: Function and disease. In: Kekelidze, T.; Holtzman, D. (_EditorsAbbr). Creatine Kinase and Brain Energy Metabolism (3−25).. Amsterdam, The Netherlands: IOS Press. (NATO Science Series: Life and Behavioural Sciences; 342).
3.1.
2003
Saks, V.; Appaix, F.; Usson, Y.; Guerrero, K.; Olivares, J.; Seppet, E.; Aliev, M.; Margreiter, R.; Kuznetsov, A. (2003). Localized control of oxidative phosphorylation within intracellular energetic units in heart cells: A possible solution of some old problems. In: Dhalla, N.S.; Hryshko, L.; Kardami, E. (_EditorsAbbr). Signal Transduction and Cardiac Hypertrophy (265−284).. Boston, USA: Kluwer Academic Publishers.
1.1.
2002
Vendelin, M.; Bovendeerd, P.; Saks, V.; Engelbrecht, J. (2002). Cardiac mechanoenergetics in silico. Neuroendocrinology Letters, 23 (1), 13−20.
1.1.
2002
Boudina, S.; Laclau, M. N.; Tariosse, L.; Daret, D.; Gouverneur, G.; Bonoron-Adele, S.; Saks, V. A.; DosSantos, P. (2002). Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart. American Journal of Physiology - Heart and Circulatory Physiology, 282 (3), H821−H831.
1.1.
2002
Aliev, M.K.; DosSantos, P.; Hoerter, J.A.; Soboll, S.; Tikhonov, A.N.; Saks, V.A. (2002). Water content and its intracellular distribution in intact and saline perfused rat hearts revisited. Cardiovascular Research, 53 (1), 48−58.
1.1.
2002
Appaix, F.; Guerrero, K.; Rampal, D.; Izikki, M.; Kaambre, T.; Sikk, P.; Brdiczka, D.; Riva-Lavieille, C.; Olivares, J.; Longuet, M.; Antonsson, B.; Saks, V. (2002). Bax and heart mitochondria: uncoupling and inhibition of respiration without permeability transition. Biochimica et Biophysica Acta, 1556, 156−167.
5.1.
2002
Saks, V.; Kay, L.; Andrienko, T.; Vendelin, M. (2002). Local restrictions of ADP diffusion between intracellular energetic units in cardiomyocytes. Biophysical Journal, 82 (1), 2991.
1.1.
2001
Walsh, B.; Tonkonogi, M.; Soderlund, K.; Hultman, E.; Saks, V.; Sahlin, K. (2001). The role of phosphorylcreatine and creatine in the regulation of mitochondrial respiration in human skeletal muscle. Journal of Physiology-London, 537 (3), 971−978.
1.1.
2001
Riva, C.; Chevrier, C.; Pasqual, N.; Saks, V.; Rossi, A. (2001). Bcl-2/Bax protein expression in heart, slow-twitch and fast-twitch muscles in young rats growing under chronic hypoxia conditions. Molecular and Cellular Biochemistry, 226, 9−16.
1.1.
2001
Laclau, M. N.; Boudina, S.; Thambo, J. B.; Tariosse, L.; Gouverneur, G.; Bonoron-Adele, S.; Saks, V.A.; Garlid, K. D.; DosSantos, P. (2001). Cardioprotection by ischemic preconditioning preserves mitochondrial function and functional coupling between adenine nucleotide translocase and creatine kinase. Journal of Molecular and Cellular Cardiology, 33 (5), 947−956.
1.1.
2001
Menin, L.; Panchichkina, M.; Keriel, C.; Olivares, J.; Braun, U.; Seppert, EK.; Saks, VA. (2001). Macrocompartmentation of total creatine in cardiomyocytes revisited. Molecular and Cellular Biochemistry, 220, 149−159.
1.1.
2001
Seppet, EK.; Kaambre, T.; Sikk, P.; Tiivel, T.; Vija, H.; Tonkonogi, M.; Sahlin, K.; Kay, L.; Appaix, F.; Braun, U.; Eimre, M.; Saks, VA. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta - Bioenergetics, 1504, 379−395.10.1016/S0005-2728(00)00269-3.
1.1.
2001
Saks, VA.; Kaambre, T.; Sikk, P.; Eimre, M.; Orlova, E.; Paju, K.; Piirsoo, A.; Appaix, F.; Kay, L.; Regitz-Zagrosek, V.; Fleck, E.; Seppet, E. (2001). Intracellular energetic units in red muscle cells. Biochemical Journal, 356, 643−657.
5.1.
2001
Saks, V.; Kay, L.; Sikk, P.; Kaambre, T.; Seppet, E.; Piirsoo, A. (2001). Intracellular energetic units in muscle cells? Biophysical Journal, 80 (1), 583A−583A.
1.1.
2000
Saks, V.A.; Kongas, O.; Vendelin, M.; Kay, L. (2000). Role of the creatine/phosphocreatine system in the regulation of mitochondrial respiration. Acta Physiologica Scandinavica, 168 (4), 635−641.10.1046/j.1365-201x.2000.00715.x.
1.1.
2000
Vendelin, M.; Kongas, O.; Saks, V. (2000). Regulation of mitochondrial respiration in heart cells analyzed by reaction-diffusion model of energy transfer. American Journal of Physiology - Cell Physiology, 278 (4), C747−C764.
1.1.
2000
Kay, L.; Nicolay, K.; Wieringa, B.; Saks, V.; Wallimann, T. (2000). Direct evidence for the control of mitochondrial respiration by mitochondrial creatine kinase in oxidative muscle cells in situ. Journal of Biological Chemistry, 275 (10), 6937−6944.
1.1.
2000
DosSantos, P.; Aliev, M. K.; Diolez, P.; Duclos, F.; Besse, P.; Bonoron-Adele, S.; Sikk, P.; Canioni, P.; Saks, V.A. (2000). Metabolic control of contractile performance in isolated perfused rat heart. Analysis of experimental data by reaction:diffusion mathematical model. Journal of Molecular and Cellular Cardiology, 32, 1703−1734.
1.1.
2000
Tiivel, T.; Kadaya, L.; Kuznetsov, A.; Kaambre, T.; Peet, N.; Sikk, P.; Braun, U.; Ventura-Clapier, R.; Saks, V.; Seppet, EK. (2000). Developmental changes in regulation of mitochondrial respiration by ADP and creatine in rat heart in vivo. Molecular and Cellular Biochemistry, 208, 119−128.
3.1.
2000
Saks, V.; Vendelin, M.; Kongas, O.; Kay, L. (2000). Creatine-phosphocreatine pathway in the intracellular networks of energy transfer and signal transduction in muscle cells. Creatine: from basic science to clinical application, 0928-9550. _EditorsAbbr Paoletti, R.; Poli, A.; Jackson, A.S. Dordrecht: Kluwer Academic Publishers, 1−9. (Medical science symposia series; 14).
5.1.
2000
Saks, VA.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Tonkonogi, M.; Seppet, E.; Sahlin, K. (2000). Metabolic channelling in cardiac cells: Dependence of kinetics of respiration regulation on source of ADP. Biophysical Journal, 78 (1), 197A−197A.
5.1.
2000
Kongas, O.; Vendelin, M.; Saks, V. (2000). In silico regulation of oxidative phosphorylation in muscle cells in health and disease. Biophysical Journal, 78 (1), 1159Pos.
1.1.
1999
Tonkonogi, M.; Walsh, B.; Tiivel, T.; Saks, V.; Sahlin, K. (1999). Mitochondrial function in human skeletal muscle is not impaired by high intensity exercise. Pflugers Archiv-European Journal of Physiology, 437 (4), 562−568.
1.2.
1999
Kongas, O.; Vendelin, M.; Saks, V. (1999). Modeling of intracellular compartmentalized energy and metabolic fluxes in the heart. Medical & Biological Engineering & Computing, 37, 27−32.
5.1.
1999
Saks, V.A.; Aliev, M.; Kongas, O.; Vendelin, M. (1999). The regulation of mitochondrial activity in muscle cells by cytosolic factors: Experimental and theoretical analyses. Biophysical Journal, 76 (1), A2, Part 2.
5.2.
1999
Kadaja, Lumme; Peet, Nadežda; Braun, U; Vibo, Riina; Metsküla, Kaja; Tiivel, Toomas; Käämbre, Tuuli; Sikk, P; Kuznetsov, A; Ventura-Clapier, R; Saks, Valdur; Seppet, Evelin (1999). Oksüdatiivse fosforüülimise postnataalne regulatsioon roti müokardis in situ. Arstiteaduskonna aastakonverents, 7. oktoober 1999 : teesid, 35−36.
1.1.
1998
Saks, V.A.; Veksler, V.I.; Kuznetsov, A.V.; Kay, L.; Sikk, P.; Tiivel, T.; Tranqui, L.; Olivares, J.; Winkler, K.; Wiedemann, F.; Kunz, W.S. (1998). Permeabilized cell and skinned fiber techniques in studies of mitochondrial function in vivo. Molecular and Cellular Biochemistry, 184, 81−100.
1.1.
1998
Saks, V.; Aliev, M.; DosSantos, P.; Vendelin, M.; Kongas, O. (1998). Mathematical model of energy transfer in hearts with inhibited or ablated creatine kinase system. Magnetic Resonance Materials in Biology, Physics, and Medicine, 6, 124−125.10.1016/S1352-8661(98)00037-4.
1.1.
1998
Voloschuk, S.G.; Belikova, Yu.O.; Klushnik, T.P.; Benivalensky, D.S.; Saks, V.A. (1998). Comparative study of the kinetics of respiration and protein content of skinned fibers from different muscle types. Biokhimiya, 63 (2), 190−193.
1.1.
1998
Saks, V.A..; VenturaClapier, R.; Leverve, X.; Rossi, A.; Rigoulet, M. (1998). What do we not know of cellular bioenergetics? – a general view on the state of the art. Molecular and Cellular Biochemistry, 184, 3−9.
1.1.
1998
Saks, V.A.; DosSantos, P.; Gellerich, F.N.; Diolez, P. (1998). Quantitative studies of enzyme - substrate compartmentation, functional coupling and metabolic channelling in muscle cells. Molecular and Cellular Biochemistry, 184, 291−307.
1.1.
1998
Aliev, M.K.; vanDorsten, F.A.; Nederhoff, M.G.; vanEchteld, C.J.A.; Veksler, V.; Nicolay, K.; Saks, V.A. (1998). Mathematical model of compartmentalized energy transfer: its use for analysis and interpretation of 31P - NMR studies of isolated heart of creatine kinase deficient mice. Molecular and Cellular Biochemistry, 184, 209−229.
1.1.
1998
Rossi, A.; Kay, L.; Saks, V.A. (1998). Early ischemia-induced alterations of the outer mitochondrial membrane and the intermembrane space: a potential cause for altered energy transfer in cardiac muscle? Molecular and Cellular Biochemistry, 184, 401−408.
1.1.
1998
Khuchua, Z.AL.; Qin, W.; Boero, J.; Cheng, J.; Payne, M.; Saks, V.A.; Strauss, A.W. (1998). Octamer formation by cardiac sarcomeric mitochondrial creatine kinase is mediated by charged N – terminal residues. Journal of Biological Chemistry, 273 (36), 22990−22996.
1.1.
1998
Novel-Chaté, V.; Mateo, P.; Saks, V.A.; Hoerter, J.A.; Rossi, A. (1998). Chronic exposure to hypoxic environment alters the mechanism of energy transfer in myocardium. Journal of Molecular and Cellular Cardiology, 30 (7), 1295−1303.
1.2.
1998
Seppet, E. K.; Kadaya, L.; Peet, N.; Käämbre, T.; Sikk, P.; Saks, V. A. (1998). The 27.5 kD protein appears to control the oxidative phosphorylation in slow twitch muscle cells. Pathophysiology, 5, 121−121.
1.1.
1997
Anflous, K.; Saks, V.; Mateo, P.; Samson, F.; Veksler, V.; Ventura-Clapier, R. (1997). Mitochondrial creatine kinase isoform expression does not correlate with its mode of action. Biochemical Journal, 322, 73−78.
1.1.
1997
Aliev, M.K.; Saks, V.A. (1997). Compartmentalised energy transfer in cardiomyocytes. Use of mathematical modelling for analysis of in vivo regulation of respiration. Biophysical Journal, 73 (1), 428−445.
1.1.
1997
Kay, L.; Daneshrad, Z.; Saks, V.A.; Rossi, A. (1997). Alteration in the control of mitochondrial respiration by outer mitochondrial membrane and creatine during heart preservation. Cardiovascular Research, 34 (3), 547−556.
1.1.
1997
Kay, L.; Saks, V.A.; Rossi, A. (1997). Early alteration of the control of mitochondrial function in myocardial ischemia. Journal of Molecular and Cellular Cardiology, 29 (12), 3399−3411.
1.1.
1997
Kay, L.; Li, ZL.; Mericskay, M.; Olivares, J.; Tranqui, L.; Fontaine, E.; Tiivel, T.; Sikk, P.; Kaambre, T.; Samuel, JL.; Rappaport, L.; Usson, Y.; Leverve, X.; Paulin, D.; Saks, VA. (1997). Study of regulation of mitochondrial respiration in vivo An analysis of influence of ADP diffusion and possible role of cytoskeleton. Biochimica et Biophysica Acta - Bioenergetics, 1322 (1), 41−59.10.1016/S0005-2728(97)00071-6.
1.1.
1996
Pelouch, V.; Kolar, F.; Khuchua, Z.; Elizarova, G.; Milerova, M.; Oštadal, B.; Saks, V. (1996). Cardiac phosphocreatine deficiency induced by GPA during postnatal development in rat. Molecular and Cellular Biochemistry, 164, 67−76.
1.1.
1996
Saks, V.A.; Ventura-Clapier, R.; Aliev, M. (1996). Metabolic control and metabolic capacity: two aspects of creatine kinase functioning in the cells. Biochimica et Biophysica Acta, 1274 (3), 81−88.
1.1.
1996
Saks, V.A.; Aliev, M.K. (1996). Is there the creatine kinase equilibrium in working heart cells? Biochemical and Biophysical Research Communications, 227 (2), 360−367.
1.1.
1996
Nascimben, L.; Ingwall, J.; Pauletto, P.; Friedrich, J.; Gwathmey, J.K.; Saks, V.A.; Pessina, A.C.; Allen, P.D. (1996). Creatine kinase system in failing and nonfailing human myocardium. Circulation, 94 (8), 1894−1901.
1.1.
1996
Saks, VA.; Tiivel, T.; Kay, L.; NovelChate, V.; Daneshrad, Z.; Rossi, A.; Fontaine, E.; Keriel, C.; Leverve, X.; VenturaClapier, R.; Anflous, K.; Samuel, JL.; Rappaport, L. (1996). On the regulation of cellular energetics in health and disease. Molecular and Cellular Biochemistry, 161, 195−208.
1.1.
1996
Kuznetsov, AV.; Tiivel, T.; Sikk, P.; Kaambre, T.; Kay, L.; Daneshrad, Z.; Rossi, A.; Kadaja, L.; Peet, N.; Seppet, E.; Saks, VA. (1996). Striking differences between the kinetics of regulation of respiration by ADP in slow-twitch and fast-twitch muscles in vivo. European Journal of Biochemistry, 241 (3), 909−915.
1.1.
1996
Bichevin, V.; Kaambre, H.; Sammelselg, V.; Kelle, H.; Asari, E.; Saks, O. (1996). Exoemissive noise activity of different metallic materials. Review of Scientific Instruments, 67 (11), 3951−3953.
1.3.
1996
Martin, Ivar; Männik, Erik; Lille, Ülo; Lakomkin, Vladimir; Steinschneider, Aleksandr; Kuznetsov, Andrei; Ljapina, Svetlana; Saks, Valdur (1996). The effect of the trimer of 16,16-dimethyl-15-keto-PGB1 on metabolic and functional post-ischemic recovery of the heart. Proceedings of the Estonian Academy of Sciences. Biology, 3/4, 93−101.
3.1.
1996
Saks, V.A.; Stepanov, V.A.; Jaliashvili, I.V.; Konorev, E.A.; Kryzanovsky, S.; Ettore, Strumia (1996). Molecular and cellular mechanisms of action for the cardioprotective and therapeutic role of creatine phosphate. M. Conway, J.F.Clark. Creatine and Creatine phosphate: scientific and clinical perspectives (91−114).. San Diego- London - New York: Academic Press.
1.1.
1995
Saks, V.; Belikova, Y.; Vasilyeva, E.; Kuznetsov, A.; Fontaine, E.; Keriel, C.; Leverve, X. (1995). Correlation between degree of rupture of outer mitochondrial membrane and changes of kinetics of regulation of respiration by ADP in permeabilized heart and liver cells. Biochemical and Biophysical Research Communications, 208 (3), 919−926.
1.1.
1995
Novel-Chate, V.; Aussedat, J.; Saks, V.A.; Rossi, A. (1995). Adaptation to chronic hypoxia alters cardiac metabolic response to  stimulation: novel face of phosphocreatine overshoot phenomenon. Journal of Molecular and Cellular Cardiology, 27 (8), 1679−1687.
1.1.
1995
Fontaine, E.M.; Keriel, C.; Lantuejoul, S.; Rigoulet, M.; Leverve, X.M.; Saks, V. (1995). Cytoplasmic cellular structures control permeability of outer mitochondrial membrane for ADP and oxidative phosphorylation in rat liver cells. Biochemical and Biophysical Research Communications, 213 (1), 138−146.
1.1.
1995
Saks, VA.; Kuznetsov, AV.; Khuchua, ZA.; Vasilyeva, EV.; Belikova, JO.; Kesvatera, T.; Tiivel, T. (1995). Control of cellular respiration in-vivo by mitochondrial outer-membrane and by creatine-kinase - a new speculative hypothesis - possible involvement of mitochondrial-cytoskeleton interactions. Journal of Molecular and Cellular Cardiology, 27 (1), 625−645.
3.4.
1995
Saks, V.A.; Kay, L.; Rossi, A.; Toompuu, M.; Utno, L.; Rätsep, I.; Sulling, T. (1995). A novel method for evaluation of efficiency of heart preservation and intraoperational protection by analysis of the respiration of skinned cardiac fibers. Heart Surgery 1995: 6th International Symposium on Cardiac Surgery. Rome (Italy), May 29-June 1st. Rome (Italy), 197−212.
1.1.
1994
Clark, J. F.; Khuchua, Z.; Kuznetsov, A.V.; Vassileva, E.; Boehm, E.; Radda, G. K.; Saks, V. A. (1994). Actions of the creatine analogue beta-guanidinopropionic acid on rat heart mitochondria. Biochemical Journal, 300, 211−216.
1.1.
1994
Saks, V. A.; Khuchua, Z. A.; Vasilyeva, E. V.; Belikova, Y. O.; Kuznetsov, A. (1994). Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration. A Synthesis. Molecular and Cellular Biochemistry, 133, 155−192.
1.1.
1994
Clark, J.F.; Kuznetsov, A.V.; Khuchua, Z.; Veksler, V.; Ventura-Clapier, R.; Saks, V. (1994). Creatine kinase function in mitochondria isolated from gravid and non-gravid guinea - pig uteri. FEBS Letters, 347, 147−151.
1.1.
1994
Saks, V. A.; Khuchua, Z. A.; Vasilyeva, E. V.; Belikova, Y. O.; Kuznetsov, A. (1994). Metabolic compartmentation and substrate channelling in muscle cells. Role of coupled creatine kinases in in vivo regulation of cellular respiration. A Synthesis. Saks V. A., Ventura-Clapier R.. Cellular Bioenergetics. Role of coupled creatine kinase (155−192).. Dordrecht-Boston-London: Kluwer Academic Publishers.
1.1.
1994
Aliev, M. K.; Saks, V. A. (1994). Mathematical modelling of intracellular transport processes and the creatine kinase systems: a probability approach. Saks V. A., Ventura-Clapier R.. Cellular Bioenergetics. Role of coupled creatine kinase (333−346).. Dordrecht-Boston-London: Kluwer Academic Publishers.
1.1.
1994
Panchenko, E.; Dobrovolsky, A.; Rogoza, A.; Sorokin, E.; Ageeva, N.; Markova, L.; Titaeva, E.; Anuchin, V.; Karpov, Y.; Saks, V. (1994). The effect of exogenous phosphocreatine on maximal walking distance, blood rheology, platelet aggregation, and fibrinolysis in patients with intermittent claudication. International Angiology, 13 (1), 59−64.
1.1.
1994
Seppet, EK.; Saks, VA. (1994). Thyroid-hormones and the creatine-kinase system in cardiac-cells. Molecular and Cellular Biochemistry, 133, 299−309.
2.1.
1994
Saks, V. A.; Ventura-Clapier, R. (toim.) (1994). Cellular Bioenergetics. Role ocoupled creatine kinase. Dordrecht-Boston: Kluwer Academic Publishers.
3.2.
1994
Kapelko, V. I.; Popovich, M. I.; Veksler, V. I.; Ventura-Clapier, R.; Khuchua, Z.A.; Saks, V. A. (1994). Subcellular basis for increased diastolic stiffness in experimental cardiomyopathies. Nagano M., Takeda N., Dhalla N. S.. The Cardiomyopathic Heart (185−195).. New York: Raven Press.
3.2.
1994
Saks, V. A.; Vasilyeva, E. V.; Khuchua, Z. A.; Belikova, Y. O.; Aliev, M. K.; Kesvatera, T.; Tiivel, T.; Anflous, K.; Ventura-Clapier, R.; Keriel, Ch.; Fontaine, E.; Leverve, X. (1994). ADP diffusion gradients and metabolic oscillatory signals to mitochondria in the heart and liver cells. Gnaiger E., Gellerich F., Wyss M., Steinlechner R., Azzone G. F.. What is controlling life. Modern trends in Biothermokinetics (178−180).. Innsbruck: Innsbruck University Press.
1.1.
1993
Nemirovskaia, T.L.; Shenkman, B.S.; Nekrasov, A.N.; Kuznetsov, A.V.; Saks, V.A. (1993). Effect of training on the structural-metabolic indicators in athletes skeletal muscles. Biokhimiya, 58 (3), 471−479.
1.1.
1993
Saks, V.A.; Vassilyeva, E.V.; Belikova, YU.O.; Kuznetsov, A.V.; Lyapina, A.; Petrova, L.; Perov, N.A. (1993). Retarded diffusion of ADP in cardiomyocytes: Possible role of outer mitochondrial membrane and creatine kinase in cellular regulation of oxidative phosphorylation. Biochimica et Biophysica Acta, 1144 (2), 134−148.
1.1.
1993
Aliev, M.K.; Saks, V. A. (1993). Quantitative analysis of the "phosphocreatine shuttle": I. A probability approach to the description of phosphocreatine production in the coupled creatine kinase - ATP/ADP translocase - oxidative phosphorylation reactions in heart mitochondria. Biochimica et Biophysica Acta, 1143 (3), 291−300.
1.1.
1993
Saks, V.A.; Strumia, E. (1993). Phosphocreatine: Molecular and cellular aspects of the mechanism of cardioprotective action. Current Therapeutical Research, 53 (5), 565−598.
1.3.
1993
Galyautdinov, G.S.; Saks, V.A.; Kots, YA.I.; Vdovenko, L.G. (1993). Clinical application of phosphocreatine (Neoton) in congestive heart failure. I. Evaluation of general clinical efficiency. Il. Cuore, 10 (2), 185−193.
1.1.
1992
Dzhavadov, S.A.; Dzokharidze, T.Z.; Dzhaliashvili, I.V.; Gelfgat, E.S.; Saks, V.A.; Pogacha, G. (1992). Energy metabolism and contractile function of the heart in diabetic cardiomyopathy: effect of ischemia and reperfusion. Biokhimiya, 57 (12), 1917−1929.
1.1.
1992
Korchazkina, O. V.; Lakomkin, V. L.; Veksler, V. I.; Elizarova, G. V.; Saks, V. A.; Kapelko, V. I.; Kupriyanov, V. V. (1992). Metabolic and functional consequances of complete inhibition of creatine kinase by iodoacetamide in the perfused heart. Biokhimiya, 57 (2), 203−213.
1.1.
1992
Branishte, T.A.; Kuznetsov, A.V.; Khuchua, Z.A.; Samko, A.N.; Naumov, V.G.; Semenovsky, M.L.; Belenkov, Iu.N.; Saks, V.A. (1992). Cellular mechanisms of impaired cardiac energetics in patients with dilated cardiomyopathy: decrease in mitochondrial respiration and creatine kinase expression. Kardiologiya, 32 (5), 13−16.
1.1.
1992
Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Korchazhkina, O.V.; Ruuge, E.K.; Saks, V.A. (1992). Functional significance of 2 pathways of energy transport in cardiomyocytes. Kardiologiya, 32 (4), 71−74.
1.1.
1992
Saks, V.A.; Konorev, E.A.; Grigoriants, R.A.; Belenkov, Iu.N. (1992). Biochemistry of normal and ischemic cardiomyocytes: current state of studies. Kardiologiya, 32 (3), 82−91.
1.1.
1992
Kuznetsov, A.V.; Veksler, V.I.; Sharov, V.G.; Dzhavadov, S.A.; Saks, V.A. (1992). Quantitative relatioship between ischemic heart disease and parameters of energy metabolism. Vestnik Rossiiskoi Akademii Meditsinskikh Nauk, 3, 21−26.
1.1.
1992
Jaliashvili, I.V.; Konorev, E.A.; Medvedeva, N.V.; Lakomkin, V.L.; Saks, V.A. (1992). The role of calcium ions in the molecular mechanism of the protective mechanism of exogenous phosphocreatine. Biokhimiya, 57 (2), 300−311.
1.1.
1992
Saks, V. A.; Dzhaliashvili, I. V.; Konorev, E. A.; Strumia, E. (1992). Molecular and cellular aspects of the cardioprotective mechanism of phosphocreatine. Biokhimiya, 57 (12), 1763−1784.
1.1.
1992
Moibenko, A.A.; Marchenko, G.I.; Kotsuruba, V.N.; Popovich, L.F.; Zarzhevskaya, V.K.; Saks, V.A. (1992). Effect of exogenous phosphocreatine on endothelium endothelium-dependent vascular reactions in immune cardiac injury. Current Therapeutical Research, 52 (6), 791−801.
1.2.
1992
Khuchua, Z.A.; Kuznetsov, A.V.; Vassilyeva, E.V.; Ventura-Clapier, R.; Clark, J.; Steinschneider, A.Ya.; Korchazhkina, O.V.; Lakomkin, V.L.; Branishte, Th.; Ruuge, E.K.; Kapelko, V.I.; Saks, V.A. (1992). The creatine kinase system and cardiomyopathy. The American Journal of Cardiovascular Pathology, 4 (3), 223−234.
1.3.
1992
Saks, V. A.; Ventura-Clapier, R. (1992). Biochemical organization of energy metabolism in muscle. J. Biochem. Organization, 1, 9−30.
3.2.
1992
Saks, V.A.; Kapelko, V.I.; Ruda, M.Y.; Semenovsky, M.L.; Strumia, E. (1992). Phosphocreatine as effective drug in clinical cardiology. P.P.De Deyn, B.Marsecau, V.Stalon and I.A.Qureshi. Guanidino Compounds in Biology and Medicine (239−248).. John Libbey & Company Ltd..
1.1.
1991
Klushnik, T.P.; Spunde, A.Ya.; Yakovlev, A.G.; Khuchua, Z.A.; Saks, V.A.; Vartanyan, M.E. (1991). b21552150Intracellular alterations of the creatine kinase isoforms in brains of schizophrenic patients. Molecular and Chemical Neuropathology, 15 (3), 271−278.
1.1.
1991
Konorev, E.A.; Medvedeva, N.V.; Dzhaliashvili, I.V.; Lakomkin, V.L.; Saks, V.A. (1991). Participation of calcium ions in the molecular mechanism of cardioprotective action of exogenous phosphocreatine. Basic research in cardiology, 86 (4), 327−339.
1.1.
1991
Konorev, E.A.; Medvedeva, N.V.; Dzhaliashvili, I.V.; Stepanov, V.A.; Saks, V.A. (1991). Effects of phosphocreatine and its structural analogues on membranes. Biokhimiya, 56 (9), 1701−1709.
1.1.
1991
Saks, V.A.; Belikova, Yu.O.; Kuznetsov, A.V. (1991). In vivo regulation of mitochondrial respiration in cardiomyocytes: Specific restrictions for intracellular diffusion of ADP. Biochimica et Biophysica Acta, 1074 (2), 302−311.
1.1.
1991
Konorev, E.A.; Sharov, V.G.; Saks, V.A. (1991). Improvement in contractile recovery of isolated rat heart after cardiologic ischemic arrest with endogenous phosphocreatine: Involvement of antiperoxidative effect? Cardiovascular Research, 25 (2), 164−171.
1.1.
1991
Seppet, EK.; Kairane, CB.; Khuchua, ZA.; Kadaya, LY.; Kallikorm, AP.; Saks, VA. (1991). Hormone regulation of cardiac energy-metabolism. 3. Effect of thyroid state on distribution of creatine-kinase isoenzymes and creatine-controlled respiration in cardiac-muscle. Journal of Applied Cardiology, 6 (5), 301−311.
1.1.
1991
Seppet, EK.; Kadaya, LY.; Hata, T.; Kallikorm, AP.; Saks, VA.; Vetter, R.; Dhalla, NS. (1991). Thyroid control over membrane processes in rat-heart. American Journal of Physiology, 261 (4), 66−71.
1.1.
1990
Konorev, E.A.; Saks, A.A.; Sharov, V.G.; Makhotina, L.A. (1990). Oxidative myocardial damage: Protective action of exogenous phosphocreatine. Biulleten eksperimental'noi biologii i meditsiny, 109 (3), 224−226.
1.1.
1990
Belikova, Yu.O.; Kuznetsov, A.V.; Saks, V.A. (1990). Specific restriction for intracellular diffusion of ADP in cardiomyocytes. Biokhimiya, 55 (11), 1944−1957.
1.1.
1990
Seppet, EK.; Kadaya, LY.; Kallikorm, AP.; Saks, VA. (1990). Hormone regulation of cardiac energy-metabolism. 2. The effect of thyroid state on the coupling between the reactions of oxidative-phosphorylation and phosphocreatine synthesis in rat-heart mitochondria. Journal of Applied Cardiology, 5 (5), 367−381.
1.1.
1990
Seppet, EK.; Kadaya, AI.; Kallikorm, AP.; Saks, VA. (1990). Synthesis of phosphocreatine in myocardial mitochondria of hyperthyroid rats. Biochemistry (Moscow), 55 (6), 809−814.
1.1.
1989
Konorev, E.A.; Saks, V.A.; Sharov, V.G.; Yevstigneeva, R.P. (1989). Improvement of contraction and metabolism of rat isolated heart in postischemic reperfusion with phosphocreatine and tocopheryl phosphate and their combinations. Vestnik Akademii Meditsinskikh Nauk SSSR, 12, 55−63.
1.1.
1989
Sharov, V.G.; Beskrovnova, N.N.; Kryzhanovsky, S.A.; Bobkov, J.G.; Saks, V.A.; Kaverina, N.V. (1989). Ultrastructure of Purkinje cells in the subendocardium and false tendons in early experimental myocardial infarction complicated by fibrillation in the dog. Virchows Archiv B-Cell Pathology, 57 (2), 131−139.
1.1.
1989
Kuznetsov, A.V.; Khuchua, Z.A.; Vassilyeva, E.V.; Medvedeva, N.V.; Saks, V.A. (1989). Heart mitochondrial creatine kinase revisited: The outer mitochondrial membrane is not important for coupling of phosphocreatine production to oxidative phosphorylation. Archives of Biochemistry and Biophysics, 268 (1), 176−190.
1.1.
1989
Kuznetsov, A.V.; Veksler, V.I.; Sharov, V.G.; Kapelko, V.I.; Saks, V.A. (1989). Estimation of functional parameters of mitochondria insitu by recording respiration of skinned heart figers. Bulletin of Experimental Biology and Medicine, 107 (2), 174−176.
1.1.
1989
Khuchua, Z.A.; VenturaClapier, R.; Kuznetsov, A.V.; Grishin, M.N.; Saks, V.A. (1989). Alteration in the creatine kinase in the myocardium of the cardiomyopathic hamsters. Biochemical and Biophysical Research Communications, 165 (2), 748−757.
1.3.
1989
Semenovsky, M.L.; Mogilevsky, G.M.; Shumakov, V.I.; Sharov, V.G.; Saks, V.A. (1989). Metabolic protection of myocardium during surgery: Blood cardioplegia in combination with exogenous phosphocreatine. Sov. Med. Rev. A. Cardiol, 2, 233−266.
1.3.
1989
Afonskaya, N.I.; Samarenko, M.B.; Vikhert, A.M.; Cherpachenko, N.M.; Sharov, V.G.; Saks, V.A.; Ruda, M.Ya. (1989). Phosphocreatine in the treatment of patients with acute myocardial infarction. Sov. Med. Rev. A. Cardiol, 2, 267−294.
1.1.
1988
Ruda, M.Ya.; Samarenko, M.B.; Afonskaya, N.I.; Saks, V.A. (1988). Reduction of ventricular arrythmias by phosphocreatine (Neoton) in patients with acute myocardial infarction. American Heart Journal, 116 (2), 393−397.
1.1.
1988
Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Severina, M.Yu.; Veksler, V.I.; Saks, V.A. (1988). The cardiac contractile failure induced by chronic creatine and phosphocreatine deficiency. Journal of Molecular and Cellular Cardiology, 20 (6), 465−479.
1.1.
1988
Kupriyanov, V.V.; Lakomkin, V.L.; Steinschneider, A.Ya.; Severina, M. Yu.; Kapelko, V.I.; Ruuge, E.K.; Saks, V.A. (1988). Relationships between pre-ischemic ATP and glycogen content and post-ischemic recovery of rat heart. Journal of Molecular and Cellular Cardiology, 20 (12), 1151−1162.
1.1.
1988
Kapelko, V.I.; Kupriyanov, V.V.; Novikova, N.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Zueva, M.Yu.; Saks, V.A. (1988). Mechanisms of the cardiac contractile function and energy metabolism adaptation to conditions of chronic depletion of phosphocreatine. Fiziologicheskii Zhurnal, 34 (1), 3−11.
1.1.
1988
Seppet, EK.; Eimre, MA.; Kallikorm, AP.; Saks, VA. (1988). Effect of exogenous phosphocreatine on heart-muscle contractility modulated by hyperthyroidism and extracellular calcium-concentration. Journal of Applied Cardiology, 3 (6), 369−380.
1.3.
1988
Saks, V.A.; Machotina, L.A.; Lakomkin, V.L.; Steinschneider, A.Ya.; Kapelko, V.I.; Preobrazhansky, A.N.; Medvedeva, N.V.; Vititnova, M.B.; Kacharava, V.P.; Kryzhanovsky, S.A.; Konorev, E.A.; Pitchugin, V.V.; Sharov, V.G.; Kaverina, N.V. (1988). Sechenov Physiological Journal of the USSR. Bull. Cardiology Research Centre USSR, 2, 42−50.
1.1.
1987
Elizarova, G. V.; Sykhanov, A. A.; Saks, V. A. (1987). Myofibrillar creatine kinase reversible binding to contractile proteins, stoichiometric ratio to myosin and functional significance. Biokhimia, 52 (4), 667−675.
1.1.
1987
Saks, V. A.; Khuchua, Z. A.; Kuznetsov, A. V. (1987). Specific inhibition of ATP-ADP translocase in cardiac mitoplasts by antibodies against mitochondrial creatine kinase. Biochimica et Biophysica Acta, 891 (2), 138−144.
1.1.
1987
Veksler, V. I.; Kuznetsov, A. V.; Sharov, V. G.; Kapelko, V. I.; Saks, V. A. (1987). Mitochondrial respiratory parameters in cardiac tissue a novel method of assessment by using saponin-skinned fibers. Biochimica et Biophysica Acta, 892 (2), 191−196.
1.1.
1987
Kupriyanov, V.V.; Steinschneider, A.Ya.; Lakomkin, V.L.; Zueva, M.Yu.; Kapelko, V.I.; Saks, V.A. (1987). Metabolism of exogenous phosphocreatine and 3-phosphono-2-imino-1-methyl-4-oxoimidazolodine in perfused rat heart during ischemia. Biokhimia, 52 (3), 437−444.
1.1.
1987
Shteinshneider, A.Ya.; Kupriyanov, V.V.; Ruuge, E.K.; Saks, V.A. (1987). 3-Phosphono-2-imino-1-methyl-4-oxoimidazolidine is a competitive substrate of AMP-dephosphorylating enzymes in rat heart cytosol. Biokhimia, 52 (4), 577−583.
1.1.
1987
Kapelko, V. I.; Saks, V. A.; Novikova, N. A.; Golikov, M. A.; Kupriyanov, V. V.; Popovoch, M. I. (1987). Adaptation of cardiac contractile function to conditions of chronic energy. Journal of Molecular and Cellular Cardiology, 19 (Suppl IV), 61.
1.1.
1987
Saks, V. A.; Kuznetsov, A. V.; Javadov, S. A.; Kupriyanov, V. V.; Sharov, V. G.; Veksler, V. I.; Kapelko, V. I. (1987). Contents of high energy phosphates and rates of mitochondrial oxidative reactions: significance for cardiac contractile function. Journal of Molecular and Cellular Cardiology, 19 (Suppl. IV), 60.
1.1.
1987
Khuchua, Z.A.; Kuznetsov, A.V.; Chernousova, G.B.; Lyulina, N.V.; Saks, V.A. (1987). Immunochemical study on the structural basis of functional coupling between creatine kinase and ATP-ADP translocase in heart mitochondria. Biologicheskie Membrany, 4 (4), 415−425.
1.1.
1987
Ventura-Clapier, R.; Saks, V. A.; Vassort, Guy; Lauer, Claudine; Elizarova, G. V. (1987). Reversible MM-creatine kinase binding to cardiac myofibrils. American Journal of Physiology-Cell Physiology, 253 (22), 444−455.
1.1.
1987
Ventura-Clapier, R.; Veksler, V. I.; Elizarova, G. V.; Mekfi, H.; Levitskaya, E. L.; Saks, V. A. (1987). Contractile properties and creatine kinase activity of myofilaments following ischemia and reperfusion of the rat heart. Biochemical Medicine and Metabolic Biology, 38 (3), 300−310.
1.1.
1987
Sharov, V. G.; Saks, V. A.; Kupriyanov, V. V.; Lakomkin, V. L.; Kapelko, V. I.; Steinschneider, A. Ya.; Javadov, S. A. (1987). Protection of ischemic myocardium by exogenous phosphocreatine (Neoton): I. Morphological and 31p-NMR studies. Journal of Thoracic and Cardiovascular Surgery, 94 (5), 749−761.
1.1.
1987
Kupriyanov, V. V.; Lakomkin, V. L.; Steinschneider, A. Ya.; Novikova, N. A.; Severina, M. Yu.; Kapelko, V. I.; Saks, V. A. (1987). The role of phosphocreatine and ATP in contraction of normal and ischemic heart. Biomedica Biochimica Acta, 46, 493−498.
1.1.
1987
Kupriyanov, V. V.; Lakomkin, V. L.; Kapelko, V. I.; Steinschneider, A. Ya.; Ruuge, E. K.; Saks, V. A. (1987). Dissociation of adenosine triphosphate levels and contractile function in isovolumic hearts perfused with 2-deoxyglucose. Journal of Molecular and Cellular Cardiology, 19 (8), 729−744.
1.1.
1987
Semenovsky, M. L.; Shumakov, V. I.; Sharov, V. G.; Mogilevsky, G. M.; Asmolovsky, A. V.; Makhotina, L. A.; Saks, V. A. (1987). Protection of ischemic mytocardium by exogenous phosphocreatine. II. Clinical, ultrastructural and biochemical evaluations. Journal of Thoracic and Cardiovascular Surgery, 94 (5), 762−769.
1.1.
1987
Seppet, EK.; Kallikorm, AP.; Javadov, SA.; Preobrazhensky, AN.; Lakomkin, VA.; Saks, VA. (1987). Energy-dependence of heart contractility impairment in conditions of calcium overload. Kardiologiya, 27 (7), 72−76.
3.1.
1987
Saks, V. A.; Kapelko, V. I.; Kupriyanov, V. V.; Khuchua, Z. A.; Lakomkin, V. L.; Novikova, N. A.; Ruuge, E. K.; Sharov, V. G.; Steinschneider, A. Ya.; Zueva, M. Yu. (1987). Control of energy transport in cardiac muscle. Dissociation of ATP levels from contractile function: cardiac failure due to phosphocreatine dediciency. Dhalla N. S., Pierce G. N., Beamish R. E.. Heart function & Metabolism (377−395).. Boston: Martinus Nijhoff Publishers.
3.2.
1987
Saks, V. A.; Bobkov, I. G. (1987). Creatine phosphate: biochemistry, pharmacology and clinical efficiency. Strumia, E.... Torino: Edizoni Minerva Medica.
3.2.
1987
Lakomkin, V. L.; Steinschneider, A. Ya.; Novikova, N. A.; Kapelko, V. I.; Saks, V. A. (1987). Phosphocreatine, ATP in energy supply for cardiac contraction. Metabolism and Development of Nervous System (276−281).. Chichester; Prague: Academia.
3.2.
1987
Kupriyanov, V. V.; Balaban, R. S.; Steinschneider, A. Ya.; Lakomkin, V. L .; Ruuge, E. K.; Smirnov, V. N.; Saks, V. A. (1987). 31p-NMR study of creatine kinase reaction mechanism in vitro and in vivo. Smirnov V. N ., Katz A .. Myocardial metabolism Cardiology reviews, suppl. 2 (120−130).. London: Harwood Academic Publishers.
3.2.
1987
Saks, V. A.; Sharov, V. G.; Kupriyanov, V. V.; Krizhanovsky, S. A.; Semenovsky, M. L.; Mogilevsky, G. M.; Lakomkin, V. L.; Steinschneider, A. Ya.; Preobrazhensky, A. N.; Javadov, S. A.; Anyukhovsky, E. P.; Beskrovnova, N. A.; Rosenschtraukh, L. V.; Kaverina, N. V. (1987). Phosphocreatine and related compounds: protective action on the ischemic myocardium. Smirnov V. N., Katz A.. Myocardial metabolism. Cardiology reviews, suppl. 2 (189−200).. London: Harwood Academic Publishers.
3.2.
1987
Saks, V. A.; Javadov, S. A.; Pozin, E.; Preobrazhensky, A. N. (1987). Biochemical basis of the protective action of phosphocreatine on the ischemic myocardium. L. D` Alessandro Case. Heart surgery-87 (155−170).. Roma: Editrice Scietifica Internationale.
1.1.
1986
Kupriyanov, V. V.; Lyulina, N. V.; Steinschneider, A. Ya.; Zueva, M. Yu.; Saks, V. A. (1986). Creatine kinase - catelyzed ATP-phosphocreatine exchange. Comparison of 31p-NMR saturation transfer technique and radioisotope tracer methods. FEBS Letters, 208 (1), 89−93.
1.1.
1986
Dzhavadov, S. A.; Preobrazhensky, A. N.; Saks, V. A. (1986). Effect of phosphocreatine on the lysophosphoglyceride level during total ischemia of rat myocardium. Biokhimia, 51 (4), 668−674.
1.1.
1986
Preobrazhensky, A.N.; Javadov, S.A.; Saks, V.A. (1986). Study on the hypothetical mechanism of protective effect of phosphocreatine on ischemic myocardium. Biokhimia, 51 (4), 675−683.
1.1.
1986
Saks, V.A.; Vassort, G.; Ventura-Clapier, R. (1986). Reversible MM-creatine kinase binding to Triton-treated isolated rat papillary muscles. Journal of Physiology-London, 377, 117.
1.1.
1986
Anyukhovsky, E. P.; Javadov, S. A.; Preobrazhensky, A. N.; Beloshapko, G. G.; Rosenshtraukh, L. V.; Saks, V.A. (1986). Effect f phosphocreatine and related compounds on the phospholipid metabolism of ischemic heart. Biochemical Medicine and Metabolic Biology, 35 (3), 327−334.
1.1.
1986
Chazov, E.I.; Semenovsky, M.L.; Smirnov, V.N.; Shumakov, V.I.; Saks, V.A.; Sharov, V.G.; Mogilevsky, G.M.; Severin, V.V.; Asmolovsky, A.V.; Makhotina, L.A. (1986). Morphological and biochemical criteria of the efficiency of clinical application of phosphocreatine (Neoton) for intraoperational protection of myocardium. Fiziologicheskii Zhurnal, 32 (1), 3−13.
1.1.
1986
Sharov, V. G.; Afonskaya, N. I.; Ruda, M. Y.; Cherpachenko, N. M.; Posin, G. Ya.; Markosyan, R. A.; Shepeleva, I. I.; Samarenko, M. B.; Saks, V. A. (1986). Protection of ischemic myocardium by exogenous phosphocreatine (Neoton): Pharmacokinatics of phosphocreatine, reduction of infarct size, stabilization of sarcolemma of ischemic cardiomyocytes and antithrombotic action. Biochemical Medicine and Metabolic Biology, 35 (1), 101−114.
1.1.
1986
Kuznetsov, A. V.; Saks, V. A. (1986). Affinity modification of creatine kinase and ATP-ADP translocase in heart mitochondria determination of their molar stoichiometry. Biochemical and Biophysical Research Communications, 134 (1), 359−366.
1.1.
1986
Saks, V. A.; Khuchua, Z. A.; Kuznetsov, A. V.; Veksler, V. I.; Sharov, V. G. (1986). Heart mitochondria in physiological salt solution not ionic strength but salt composition is important for association of creatine kinase with the inner membrane surface. Biochemical and Biophysical Research Communications, 139 (3), 1262−1271.
3.1.
1986
Saks, V. A.; Kuznetsov, A. V.; Khuchua, Z.; Kupriyanov, V. V. (1986). Compartmentation of adenine nucleotides and phosphocreatine shuttle in cardiac cells some new evidence. Brautbar N.. Advances in experimental medicine and biology (103−116).. New York: Plenum Press.
3.2.
1986
Belenkov, Yu. N.; Saks, V. A.; Sharov, V. G.; Semenovsky, M. L.; Mogilevsky, G. M.; Afonskaya, N. I.; Ruda, M. Y.; Samarenko, M. B. (1986). Phosphocreatine action on ischemic myocardium experimental research and clinical trial. Mason Ztacia. Progress in Molecular Genetics and Frontiere della Cardiologia (111−133).. Milano: x.
5.1.
1986
Seppet, E.; Kallikorm, A.; Saks, V.; Antaloczy, Z. (1986). Effect of phosphocreatine on hyperthyroid rat-heart contractility. Acta Physiologica Hungarica, 68, 282−282.
1.1.
1985
Rosenshtraukh, L. V.; Saks, V. A.; Anyukovsky, E. P.; Beloshapko, G. G.; Yushmanova, A. V. (1985). The antiarrhythmic action of phosphocreatine in acute myocardial ischemia. Biochemical Medicine, 34 (1), 120−128.
1.1.
1985
Seppet, EK.; Aodyaan, AJ.; Kallikorm, AP.; Chernousova, GB.; Lyulina, NV.; Sharov, VG.; Severin, VV.; Popovich, MI.; Saks, VA. (1985). Hormone regulation of cardiac energy-metabolism. 1. Creatine transport across cell-membranes of euthyroid and hyperthyroid rat-heart. Biochemical Medicine, 34 (3), 267−279.
1.1.
1985
Saks, V. A.; Kuznetsov, A. V.; Kupriyanov, V. V.; Miceli, M. V.; Jacobus, W. J. (1985). Creatine kinase of rat heart mitochondria. The demostration of functional coupling to oxidative phosphorylation in an inner membrane-matrix preparation. Journal of Biological Chemistry, 260 (12), 7757−7764.
1.1.
1985
Mogilevsky, G.M.; Sharov, V.G.; Saks, V.A.; Semenovsky, M.L. (1985). Structural-biochemical characterization of the efficiency of the intraoperational myocardium protection. Arkhiv Patologii, 47 (6), 24−29.
1.3.
1985
Kupriyanov, V.V.; Steinschneider, A.Ya.; Lakomkin, V.L.; Ruuge, E.K.; Kapelko, V.I.; Saks, V.A. (1985). 31P-NMR study of protective effect of phosphocreatine on ischemic myocardium under cardioplegia. Bull. Cardiology Research Centre USSR, 1, 14−19.
3.2.
1985
Saks, V. A.; Sharov, G.; Kupriyanov, V. V.; Semenovsky, M. L.; Mogilevsky, G. M.; Lakomkin, V. L.; Steinschneider, A. Ya.; Afonskaya, N. I.; Ruda, M.Ya.; Samarenko, M. B. (1985). Phosphocreatine and myocardial protection: biochemical, pharmacological and clinical aspects. Conoscere e curare il cuore 85 (348−373).. Rome: Schiaparelli Farmaceutici.
3.4.
1985
Saks, V. A.; Kupriyanov, V. V.; Ventura-Clapier, R. (1985). Mechanism of energy supply for contraction: biochemical and NMR studies. Proceedings of the 16th FEBS Congress, part A. VNU Science press, 281−290.
1.1.
1984
Kupriyanov, V. V.; Steinschneider, A. Ya.; Ruuge, E. K.; Kapelko, V. I.; Zueva, M. Ya.; Lakomkin, V. L.; Smirnov, V. N.; Saks, V. A. (1984). Regulation of energy flux through the creatine kinase reaction in vitro and in perfused rat heart. 31p-NMR Studies. Biochimica et Biophysica Acta, 805 (4), 319−331.
1.1.
1984
Saks, V. A.; Ventura-Clapier, R.; Khuchua, Z. A.; Preobrazhensky, A. N.; Emelin, I. V. (1984). Creatine kinase in regulation of heart function and metabolism. I Further evidence for compartmentation of adenine nucleotides in cardiac myofibrillar and sarcolemmal coupled ATPase-creatine kinase systems. Biochimica et Biophysica Acta, 803 (4), 254−264.
1.1.
1984
Seppet, EK.; Adoyaan, AI.; Kallikorm, AP.; Chernousova, GV.; Lyulina, NV.; Severin, VV.; Popovich, MI.; Saks, VA. (1984). Hyperthyroid cardiomyopathy - abnormalities in creatine transport and hypersensitivity to ischemic-injury. Vestnik Akademii Meditsinskikh Nauk SSSR, 10, 48−56.
1.2.
1984
Saks, V. A.; Sharov, V. G.; Kupriyanov, V. V.; Smirnov, V. N.; Semenovsky, M. L. (1984). Protective action of phosphocreatine on ischemic myocardium. Journal of Molecular and Cellular Cardiology, 16 (Suppl. 2), 113.
3.1.
1984
Saks, V. A.; Chernousova, G. B.; Lyulina, N. V.; Khuchua, Z. A.; Preobrazhensky, A. N.; Ventura-Clapier, R. (1984). Role of multienzyme complexes in intracellular compartmentation of adenine nucleotides and in regulation of cardiac energy metabolism. Cellular and molecular aspects of the regulation of the heart (41−48).. Berlin: Akademie Verlag Gmbh.
1.1.
1983
Gellerich, F. N.; Schlame, M.; Saks, V. A. (1983). Creatine kinase of heart mitochondria: no changes in its kinetic properties after inhibition of the adenine nucleotide translocator. Biomedica Biochimica Acta, 42 (10), 1335−1337.
1.1.
1983
Kupriyanov, V. V.; Preobrazhensky, A. N.; Saks, V. A. (1983). Mechanism of passive Ca2+ permeability of vesicular sarcolemmal preparations from rat hearts. Biochimica et Biophysica Acta, 728 (2), 239−253.
1.1.
1983
Kupriyanov, V. V.; Steinschneider, A. Ya.; Ruuge, E. K.; Smirnov, V. N.; Saks, V. A. (1983). 31p-NMR SPECTRUM of phosphocreatine: ducterium-induced splitting of the signal. Biochemical and Biophysical Research Communications, 114 (3), 1117−1125.
1.1.
1982
Preobrazhenskii, A. N.; Kupriyanov, V. V.; Saks, V. A.; Grosse, R.; Spitzer, E. (1982). Effect of cardenolids and sodium ion gradient on ATP - dependent Ca2+ accumulation in cardiac sarcolemmal vesicles. Biokhimia, 47 (1), 126−136.
1.1.
1982
Gellerich, F.; Saks, V. A. (1982). Control of heart mitochondrial oxygen consumption by creatine kinase: the importance of enzyme localization. Biochemical and Biophysical Research Communications, 105 (4), 1473−1481.
1.2.
1982
Saks, V. A.; Kupriyanov, V. V. (1982). Intracellular energy transport and control of cardiac contraction. Advances in Myocardiology, 3, 475−497.
1.2.
1982
Preobrazhensky, A. N.; Saks, V. A. (1982). The cardiac sarcolemmal protein kinase reaction. Kinetic characteristics and sensitivity to cyclic AMP. Advances in Myocardiology, 3, 273−288.
1.1.
1981
Kupriyanov, V. V.; Elizarova, G. V.; Saks, V. A. (1981). Determination of molar content of creatine kinase in cardiac mitochondria by SH - reagents. Biokhimia, 46 (5), 930−941.
1.1.
1981
Preobrazhensky, A.N.; Saks, V.A. (1981). Some properties of the reaction catalyzed by protein kinase bound to cardiac sarcolemma. Biokhimia, 46 (9), 1681−1693.
1.1.
1981
Kupriyanov, V. V.; Preobrazhensky, A. N.; Saks, V. A. (1981). Study of passive Ca2+ permeability of ventricular sarcolemmal preparations from myocardium. Biokhimia, 46 (10), 1863−1879.
1.1.
1980
Saks, V. A.; Kupriyanov, V. V.; Elizarova, G. V.; Jacobus, W. E. (1980). Studies of energy transport in heart cells. The importance of creatine kinase localization for the coupling of mitochondrial phosphorylcreatine production to oxidative phosphorylation. Journal of Biological Chemistry, 255 (2), 755−763.
1.1.
1980
Kupriyanov, V.V.; Panasenko, N.A.; Saks, V.A. (1980). The kinetics of the interaction of analogs of guanidine substrates with muscle creatine kinase. Bioorganicheskaya Khimiya, 6 (1), 116−137.
1.1.
1980
Saks, V.A.; Smirnov, V.N. (1980). Molecular mechanisms of changes in myocardial energy metabolism in pathological conditions. Kardiologiya, 20 (5), 10−12.
1.1.
1980
Grosse, R.; Spitzer, E.; Kupriyanov, V. V.; Saks, V. A.; Repke, K. K. H. (1980). Coordinate interplay between (n+, K+ ) antiport across the membrane of resieles forward from the plasme membrane of cardiac muscle cells. Biochimica et Biophysica Acta, 603 (1), 142−156.
1.1.
1980
Kupriyanov, VV.; Seppet, EK.; Emelin, IV.; Saks, VA. (1980). Phosphocreatine production coupled to the glycolytic reactions in the cytosol of cardiac-cells. Biochimica et Biophysica Acta, 592 (2), 197−210.
3.2.
1980
Rosenshtraukh, L. V.; Saks, V. A.; Sharov, V. G.; Yuryavichyus, I. A.; Chazov, E. I. (1980). Regulation of mechanical and electrical activity of the hypodynamic myocardium by creatine phosphate. Energy transport, protein synthesis and hormonal control of heart metabolism (89−112).. Betheda: US Department of Health and Human Services.
3.2.
1980
Chazov, E. I.; Smirnov, V. N.; Saks, V. A.; Rosenshtraukh, L. V.; Lipina, N. V.; Levitsky, D. O. (1980). Energy metabolism and ion fluxes across cardiac membranes. M. Tajuddin, P. K. Das, M. Tariq, N. S. Dhalla. Advances in myocardiology (1).. Baltimore: University Park Press.
3.2.
1980
Saks, V. A.; Kupriyanov, V. V.; Elizarova, G. V.; Seppet, E. K.; Jacobus, W. E. (1980). Regulation of phosphorylcreatine synthesis in myocardial cells: the coupling of transphosphorylation to glycosis and mitochondrial oxidative phosphorylation and the significance of creatine kinase compartmentation. Energy transport, protein synthesis and hormonal control of heart metabolism (89−112).. Betheda: US Department of Health and Human Services. (NIH Publication ; N 80 - 2017).
3.2.
1980
Saks, V.A. (1980). Creatine kinase isoenzymes and control of cardiac contraction. Jacobus J. W., Ingwall J.. Heart creatine kinase: the integration of isoenzymes for energy distribution (109−124).. Baltimore: Williams & Wilkins.
1.1.
1979
Rosenshtraukh, L. V.; Saks, V. A.; Yuriavichus, I. A.; Nesterenko, N. V.; Undrovinas, A. I.; Smirnov, V. N.; Chazov, E. I. (1979). Effect of creatine phosphate on the slow inward calcium current, action potential and the contractile force of frog attrium and ventricle. Biochemical Medicine, 21 (1), 1−15.
1.1.
1979
Sharov, V.G.; Shepeleva, I.I.; Saks, V.A. (1979). Electron microscopic investigation of permeability of the sarcolemma of rat cardiac myocytes during acute anoxia of the myocardium. Bulletin of Experimental Biology and Medicine, 88 (8), 917−921.
1.1.
1979
Kupriyanov, V.V.; Seppet, E.K.; Emelin, I.V.; Saks, V.A. (1979). Steady state kinetics of pyruvate kinase from muscle. Biokhimia, 44 (1), 104−115.
1.1.
1979
Erashova, N.S.; Saks, V.A.; Sharov, V.G.; Lyzlova, S.N. (1979). Creatine kinase from muscle cell nuclei. Biokhimia, 44 (2), 372−378.
1.1.
1979
Saks, V.A.; Kats, V.M.; Vetter, R.; Lylina, V.N.; Shell, W. (1979). The effect of calcium ions on the creatine kinase systems of myocardial cells. Biokhimia, 44, 1600−1611.
1.1.
1979
Saks, VA.; Seppet, EK.; Smirnov, VN. (1979). Does oxidative-phosphorylation increase the rate of creatine-phosphate synthesis in heart-mitochondria or not. Journal of Molecular and Cellular Cardiology, 11 (12), 1265−1273.
1.1.
1979
Kupriyanov, VV.; Seppet, EK.; Emelin, IV.; Saks, VA. (1979). Steady-state kinetics of muscular pyruvate-kinase. Biochemistry (Moscow), 44 (1), 87−95.
1.3.
1979
Rosenshtraukh, L. V.; Saks, V. A.; Yuriavichus, I. A.; Nesterenko, N. V.; Undrovinas, A. I.; Smirnov, V. N. (1979). Effect of creatine phosphate on the slow inward calcium current, action potential, and the contractile force of frog atrium and ventricle. Fisioliologitšeski Zhurnal SSSR, 65, 405−413.
1.3.
1979
Shepeleva, I.I.; Saprygin, D.B.; Saks, V.A.; Kramer, A.A.; Kashtelyan, L.S. (1979). Experimental substantiation of myocardial affection visualization by means of pyrophosphate-99m Tc. Meditsinskaya Radiologiya, 3, 16−22.
1.1.
1978
Kupriyanov, V.V.; Seppet, E.K.; Saks, V.A. (1978). Creatine phosphate synthesis coupled to the glycolytic reactions in heart cells cytosol. Biokhimia, 43 (8), 1468−1476.
1.1.
1978
Saks, V. A.; Rosenshtraukh, L. V.; Smirnov, V. N.; Chazov, E. I. (1978). Role of creatine phosphokinase in cellular function and metabolism. Canadian Journal of Physiology and Pharmacology, 56 (5), 691−706.
1.1.
1978
Rosenshtraukh, L. V.; Saks, V. A.; Undrovinas, A. I.; Chazov, E. I.; Smirnov, V. N.; Sharov, V. G. (1978). Studies of energy transport in heart cells. The effect of creatine phosphate on the frog ventricular contractile force and action potential duration. Biochemical Medicine, 19 (2), 148−164.
1.1.
1978
Levitsky, D. O.; Levchenko, T. S.; Saks, V. A.; Sharov, V. G.; Smirnov, V. N. (1978). The role of creatine phosphokinase in supplyng energy for the calcium pump system of heart sarcoplasmic reticulum. Membrane Biochemistry, 2 (1), 81−96.
1.1.
1978
Erashova, N. S.; Saks, V. A.; Sharov, V. G.; Lyzlova, S. N. (1978). Creatine kinase bound to cardiac cells nuclei. Biochemical and Biophysical Research Communications, 82 (4), 1217−1222.
1.1.
1978
Sharov, V.G.; Orlova, Z.R.; Saks, V.A. (1978). Ultrastructural bases of acute cardiac insufficiency not associated with rhythm disorders. Arkhiv Patologii, 40 (10), 3−14.
1.1.
1978
Seppet, EK.; Kupriyanov, VV.; Saks, VA. (1978). Adenylate kinase from heart. 2. Steady-state kinetics of reverse reaction (adp formation). Bioorganicheskaya Khimiya, 4 (1), 95−108.
1.1.
1978
Kupriyanov, VV.; Seppet, EK.; Saks, VA. (1978). Creatine-phosphate synthesis coupled with glycolytic reactions in myocardial-cell cytosol. Biochemistry (Moscow), 43 (8), 1153−1161.
1.1.
1977
Saks, V.A.; Seppet, E.K.; Lyulina, N.V. (1977). A comparative study of the role of creatine phosphokinase isoenzymes in energy metabolism of skeletal and heart muscle. Biokhimia, 42 (4), 579−588.
1.1.
1977
Levitsky, D.O.; Levchenko, T.S.; Saks, V.A.; Sharov, V.G.; Smirnov, V.N. (1977). The functional coupling between Ca2+ -ATPase and creatine phosphokinase in heart muscle sarcoplasmic reticulum. Biochimia, 42 (10), 1766−1773.
1.1.
1977
Sharov, V. G.; Saks, V. A.; Smirnov, V. N.; Chazov, E. I. (1977). An electron microscopic histochemical investigation of creatine phosphokinase in heart cells. Biochimica et Biophysica Acta, 468 (3), 495−501.
1.1.
1977
Saks, V. A.; Lipina, N. V.; Sharov, V. G.; Smirnov, V. N.; Chazov, E. I.; Grosse, Richard (1977). The localization of the MM isoenzyme of creatine phosphokinase on the surface membrane of myocardial vells and its functional coupling to analain-inhibited (Na+, K+ ) ATPase. Biochimica et Biophysica Acta, 465 (3), 550−558.
1.1.
1977
Kupriyanov, VV.; Seppet, EK.; Saks, VA. (1977). Adenylate kinase from heart. 1. Kinetics of forward reaction. Bioorganicheskaya Khimiya, 3 (12), 1682−1695.
1.1.
1977
Saks, VA.; Seppet, EK.; Lyulina, NV. (1977). Comparative investigation of role of creatine-phosphokinase isoenzymes in energy-metabolism of skeletal-muscles and myocardium. Biochemistry (Moscow), 42 (4), 445−452.
1.3.
1977
Rosenshtraukh, L.V.; Saks, V.A.; Undrovinas, A.I.; Yuryavichus, A.I.; Yushmanova, A.V.; Sharov, V.G.; Seppet, E.K.; Smirnov, V.N.; Chazov, E.I. (1977). The role of creatine phosphokinase systems in regulation of the force of contraction of frog heart muscle. Fisioliologitšeski Zhurnal SSSR, 63, 681−688.
1.1.
1976
Saks, V. A.; Lipina, N. V.; Smirnov, V. N.; Chazov, E. I. (1976). Studies of energy transport in heart cells. The functional coupling between mitochondrial creatine phosphokinase and ATP-ADP translocase: kinetic evidence. Archives of Biochemistry and Biophysics, 173 (1), 34−41.
1.1.
1976
Saks, V. A.; Chernousova, G. B.; Vetter, R.; Smirnov, V. N.; Chazov, E. I. (1976). Kinetic propenties and the functional role of particulate MM-isoenzyme of creatine phosphokinase bound to heart muscle myofibrilis. FEBS Letters, 62 (3), 293−296.
1.1.
1976
Saks, V.A.; Lipina, N.V.; Chernousova, G.B.; Sharov, V.G.; Smirnov, V.N.; Grosse, R. (1976). Functional coupling of MM isoenzyme of creatine kinase with MgATPase of myofibrils and Na,K-ATPase of plasmatic membrane of heart cells. Biochimia, 41 (12), 2099−2109.
1.1.
1976
Saks, V. A.; Lipina, N.V.; Lyulina, N.V.; Chernousova, G.B.; Vetter, R.; Smirnov, V.N.; Chazov, E.I. (1976). Functional characteristics of creatine kinase reactions in heart mitochondria and myofibrils. Biochimia, 41 (8), 1450−1470.
1.1.
1976
Saks, V. A.; Rosenshtraukh, L. V.; Undrovinas, A. I.; Smirnov, V. N.; Chazov, E. I. (1976). Studies of energy transport in heart cells. Intracellular creatine content as a regulatory factor of frog heart energetics and fonce of contraction. Biochemical Medicine, 16 (1), 21−36.
1.3.
1976
Rosenshtraukh, L.V.; Saks, V.A.; Undrovinas, A.I.; Yushmanova, A.V.; Smirnov, V.N.; Chazov, E.I. (1976). A study of the dependence of the frog heart muscle contractile force àn intracellular energy transport processes. Fisioliologitšeski Zhurnal SSSR, 62, 1199−1210.
1.1.
1975
Saks, V. A.; Chernousova, G. B.; Gukovsky, D. E.; Smirnov, V. N.; Chazov, E. I. (1975). Studies of Energy Transport in heart cells. Mitochondrial isoenzyme of creatine phosphokinase: kinetic properties and regulatort action of Mg 2+ ions. European Journal of Biochemistry, 57 (1), 273−290.
1.3.
1975
Saks, V.A.; Lyulina, N.V.; Chernousova, G.B.; Voronkov, Yu.I.; Smirnov, V.N.; Chazov, E.I. (1975). Study of the role of mitochondrial creatine kinase in the process of energy transport in the heart cells. Kardiologiya, 9, 103−110.
1.1.
1974
Saks, V. A.; Chernousova, G. B.; Voronkov, U. I.; Smirnov, V. N.; Chazov, E. I. (1974). Study of energy transport mechanism in myocardial cells. Circulation Research, 34-35 (Suppl. III), 138−149.
1.3.
1974
Saks, V.A.; Voronkov, Yu.I. (1974). Diagnostic significance of serum creatine kinase activity in myocardial infarction. Terapevticheskii Arkhiv, 6, 32−38.
21.04.2019
Detailne otsing
  • Leitud 9 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF7117Energeetilise metabolismi kompartmentaliseeritud süsteemid ja nende häired südame-, maoepiteeli- ja ajurakkudes01.01.200731.12.2010Enn SeppetTartu Ülikool, Arstiteaduskond75 160,08 EUR
IUTIUT23-1Integreeritud energeetilise metabolismi regulatsioonimehhanismid kasvaja- ning lihasrakkudes. 01.01.201431.12.2019Tuuli KäämbreKeemilise ja Bioloogilise Füüsika Instituut1 013 400,00 EUR
SFSF0180114Bs08Integreeritud energeetilise metabolismi regulatsioonimehhanismid lihasrakkudes01.01.200831.12.2013Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut657 119,57 EUR
ETFETF6142Kompartmentaliseeritud energia transpordi võrgud kardiomüotsüütides ja eelkohastumise mehhanismid01.01.200531.12.2008Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut91 581,62 EUR
ETFETF5515Mitokondrite ja ATPaaside funktsionaalsed kompleksid kui energeetilise metabolismi põhiüksused oksüdatiivsetes lihasrakkudes01.01.200331.12.2006Enn SeppetTartu Ülikool, Arstiteaduskond61 035,62 EUR
SFSF0182549Bs03Mitokondrite ja ATPaaside integratsiooni ja regulatsiooni mehhanismid normaalses oksüdatiivses lihasrakus01.01.200331.12.2007Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut229 890,20 EUR
ETFETF7823Raku energiaühikute moodustumise dünaamika tüvirakkude differentseerumise protsessis lihasrakkudeks ja nende degradatsioon vananemise käigus01.01.200931.12.2012Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut88 352,54 EUR
ETFETF8987Vähirakkude bioenergeetilise profiili määramine diagnostikas ja ravis. 01.01.201231.12.2015Tuuli KäämbreKeemilise ja Bioloogilise Füüsika Instituut69 600,00 EUR
APSF0180114Bs08APVäikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180114Bs08 raames01.01.201031.12.2011Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut63 533,29 EUR