Eesti Teadusinfosüsteem

Patentne leiutis: Self-replicating vector for dna immunization against hiv ; Omanikud: FINNISH IMMUNOTECHNOLOGY LTD; Autorid: Pärt Peterson, Marja Tähtinen, Kai Krohn, Annamari Päivi Ranki; Prioriteedi number: FI19980000463 19980227; Prioriteedi kuupäev: 27.02.1998.

Patentne leiutis

Self-replicating vector for dna immunization against hiv

Self-replicating vector for dna immunization against hiv

A nucleotide sequence encoding the HIV regulatory protein NEF, REV or TAT or an immunologically active fragment thereof is inserted into a vector comprising papilloma virus nucleotide sequences necessary and sufficient for long-term persistence. The resulting vectors are self-replicating and have a high copy number. They express the HIV genes in high amounts for a long period of time. The vectors elicit both a humoral and cell-mediated immune response and are therefore potential DNA immunization vaccines against HIV. The invention is directed to said vectors and vaccines and to a method for preparing the vectors. The invention is further directed to a host cell comprising the vector, to the use of the vector in the manufacture of a vaccine and to a method of preventing or treating HIV.

27.02.1998

FI19980000463 19980227

Rahvusvaheline (IPC)

international: A61P31/18; C07K14/16; C12N15/48; C12N15/49; C12N15/79; C12N15/85; A61K39/00; C12N15/63; (IPC1-7): A61K48/00; C12N15/49; C12N15/86 cooperative: C07K14/005; C12N15/85; A61K2039/51; A61K39/00; C12N2740/16322; C12N2800/108; C12N2830/42; C12N2840/20

C07K14/16

Soome Vabariik

Kaitstud