GLUTHIONE ANALOGUES AND THEIR USE AS ANTIOXIDANTS
Patentne leiutis: GLUTHIONE ANALOGUES AND THEIR USE AS ANTIOXIDANTS; Omanikud: Vulpes Ltd; Autorid: Ursel Soomets, Mihkel Zilmer, Ülo Langel, Eero Vasar; Prioriteedi number: 0002232-7; Prioriteedi kuupäev: 15.06.2000.
Patentne leiutis
GLUTHIONE ANALOGUES AND THEIR USE AS ANTIOXIDANTS
GLUTHIONE ANALOGUES AND THEIR USE AS ANTIOXIDANTS
Glutathione analogues are disclosed. These have Formula (I): X-Glu-Y-Gly-Z, wherein Glu is glutamyl or $g(g)-glutamyl, and Gly is glycine or glycyl, X is selected from the group consisting of H-; (O-R)tyrosyl; biotinyl-(O-R)tyrosyl; anthraniloyl-(O-R)tyrosyl; (O-R) tyrosyl-aminohexanoyl-; and 5-alkoxy tryptophyl-; Y is selected from the group consisting of cysteinyl, serinyl, methionyl or selenocysteinyl; and Z is selected from the group consisting of -H; (O-R)tyrosine; and aminohexanoyl-(O-R)tyrosine, and wherein each amino acids can be either a L- or a D- enantiomer; the peptide bonds may optionally be methylated, and the carboxyl groups are free acids, amides, or mono- or di-alkyl esters, and R is selected from alkyl, alkenyl, aryl and aryl containing one or several heteroatoms in the ring(s); with the provisio that X is not H when Y is L-cysteinyl and Gly is L-glycyl. Glutathione analogues for use as antioxidants, e.g. in cosmetics and pharmaceutical compositions, use of the gluthathione analogues for the manufacture of a medicament for the prophylactic and/or therapeutic treatment of a disease or disorder associated with oxidative degeneration of cells, such as Alzheimer's disease or Parkinson's disease, and a method of such treatment, are also described.
  • Vulpes Ltd
Prioriteeditaotlus
15.06.2000
0002232-7
Rahvusvaheline (IPC)
C07K 5/02 (2006.01), A61K 38/00 (2006.01)
Rootsi Kuningriik
Kaitstud
Järgnevad taotlused (1)
KuupäevNumberPatendiametRiikURLFailStaatus
14.06.2001PCT/SE2001/001351WIPOKaitstud