Thomas Fehniger

27.07.1948
+ 372 620 4460
+46 738328012
thomas.fehniger@telia.com

Teenistuskäik

Töökohad ja ametid
01.01.2009–...    Senior Researcher; Department of Electrical Measurements, Lund Institute of Technology (LTH), Lund University
2009–31.12.2012    Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut , Kliinilise medistsiini õppetool, Professor (0,50)
01.01.2005–31.12.2009    Category Manager of Human Clinical Samples, AstraZeneca R&D, Sweden
01.01.1999–31.12.2004    Team Leader, Translational Sciences, AstraZeneca R&D, Respiratory and Inflammation, Lund Sweden
01.01.1998–31.12.1999    Astra Draco AB, Lund, juhtivteadur immunofarmakoloogia alal
01.01.1992–31.12.1995    Stocholmi Linnavalitsus,Stocholmi Mikrobioloogia Laboratoorium, viroloog
01.01.1989–31.12.1998    Nakkushaiguste osakond, Karolinska Instituut, Stocholm, Immunoloogia osakond, Stocholmi Ülikool, teadur (HIV viroloogia ja tsütokiinide bioloogia)
01.01.1988–31.12.1989    Dept of Infectious Diseases, Roslagstull Hospital,Karolinska Institute, Stockholm,Visiting Scientist of the Swedish Medical Research Council
01.01.1985–31.12.1988    Armauer Hansen Institute, All Africa Leprosy and Rehabilitation Hospital, Addis Ababa, Ethiopia,Field Research in tropical infectious diseases, HIV,Addis Ababa University, Thesis advisor of two graduate students
01.01.1975–31.12.1985    Dept Microbiology and Immunology, School of Medicine,University of California at Los Angeles, Graduate degree studies,Staff Research Associate
01.01.1973–31.12.1975    Surgery Branch, National Cancer Institute, Bethesda USA,,Biomedical research trainee, Biologist
 
 
Haridustee
1993–1993    Associate Professor (Docent) in Immunology,Stockholm University, Sweden
1980–1985    School of Medicine, University of California, Los Angeles,Doctor of Medical Microbiology and Immunology

Kvalifikatsioon

 
 
Teadustöö põhisuunad
VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin
VALDKOND: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika
VALDKOND: 4. Loodusteadused ja tehnika; 4.9. Meditsiinitehnika

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2013
1.1.
2013
1.1.
2013
5.2.
2013
1.1.
2012
1.1.
2012
1.2.
2012
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.2.
2011
2.2.
2011
3.2.
2011
1.1.
2010
1.2.
2010
1.2.
2010
3.1.
2009
3.5.
2009
5.1.
2009
5.1.
2009
1.1.
2008
1.1.
2007
5.1.
2007
5.1.
2007
1.1.
2006
1.1.
2005
1.1.
2005
1.2.
2005
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2003
1.1.
2003
1.1.
2002
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2000
3.2.
2000
1.1.
1999
1.1.
1999
1.1.
1999
1.1.
1999
1.1.
1998
1.1.
1998
3.1.
1998
1.1.
1997
1.1.
1997
1.1.
1997
5.1.
1997
5.2.
1997
1.1.
1996
1.1.
1996
1.1.
1995
5.1.
1995
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1991
3.1.
1991
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1988
1.1.
1988
1.1.
1987
1.2.
1987
1.1.
1986
1.1.
1986
1.1.
1986
1.1.
1986
1.2.
1986
2.3.
1985
1.1.
1984
1.1.
1983
1.1.
1983
1.1.
1982
1.1.
1982
1.1.
1979
1.1.
1976
1.1.
1976

Thomas Fehniger

27.07.1948
+ 372 620 4460
+46 738328012
thomas.fehniger@telia.com

Career

Institution and position
01.01.2009–...    Senior Researcher; Department of Electrical Measurements, Lund Institute of Technology (LTH), Lund University
2009–31.12.2012    Tallinn University of Technology , Technomedicum of TUT, Department of Clinical Medicine, Chair of Clinical Medicine, Professor (0,50)
01.01.2005–31.12.2009    Category Manager of Human Clinical Samples, AstraZeneca R&D, Sweden
01.01.1999–31.12.2004    Team Leader, Translational Sciences, AstraZeneca R&D, Respiratory and Inflammation, Lund Sweden
01.01.1998–31.12.1999    Astra Draco AB, Lund. Principle Scientist in Immunopharmacology
01.01.1992–31.12.1995    Stockholms County Council, Stockholm Central Microbiological Laboratories, Stockholm. Clinical diagnostic virology
01.01.1989–31.12.1998    Dept of Infectious Diseases, Karolinska Institute, Stockholm and Dept of Immunology, Stockholm University, Researcher in HIV virology, cytokine biology
01.01.1988–31.12.1989    Dept of Infectious Diseases, Roslagstull Hospital,Karolinska Institute, Stockholm,Visiting Scientist of the Swedish Medical Research Council
01.01.1985–31.12.1988    Armauer Hansen Institute, All Africa Leprosy and Rehabilitation Hospital, Addis Ababa, Ethiopia,Field Research in tropical infectious diseases, HIV,Addis Ababa University, Thesis advisor of two graduate students
01.01.1975–31.12.1985    Dept Microbiology and Immunology, School of Medicine,University of California at Los Angeles, Graduate degree studies,Staff Research Associate
01.01.1973–31.12.1975    Surgery Branch, National Cancer Institute, Bethesda USA,,Biomedical research trainee, Biologist
 
 
Education
1993–1993    Associate Professor (Docent) in Immunology,Stockholm University,Sweden
1980–1985    School of Medicine, University of California, Los Angeles,Doctor of Medical Microbiology and Immunology

Qualifications

 
 
Field of research
FIELD OF RESEARCH: 3. Health; 3.1. Biomedicine
FIELD OF RESEARCH: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies
FIELD OF RESEARCH: 4. Natural Sciences and Engineering; 4.9. Medical Engineering
 
 

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2013
1.1.
2013
1.1.
2013
5.2.
2013
1.1.
2012
1.1.
2012
1.2.
2012
1.1.
2011
1.1.
2011
1.1.
2011
1.1.
2011
1.2.
2011
2.2.
2011
3.2.
2011
1.1.
2010
1.2.
2010
1.2.
2010
3.1.
2009
3.5.
2009
5.1.
2009
5.1.
2009
1.1.
2008
1.1.
2007
5.1.
2007
5.1.
2007
1.1.
2006
1.1.
2005
1.1.
2005
1.2.
2005
1.1.
2004
1.1.
2004
1.1.
2004
1.1.
2003
1.1.
2003
1.1.
2002
1.1.
2001
1.1.
2001
1.1.
2001
1.1.
2000
3.2.
2000
1.1.
1999
1.1.
1999
1.1.
1999
1.1.
1999
1.1.
1998
1.1.
1998
3.1.
1998
1.1.
1997
1.1.
1997
1.1.
1997
5.1.
1997
5.2.
1997
1.1.
1996
1.1.
1996
1.1.
1995
5.1.
1995
1.1.
1992
1.1.
1992
1.1.
1992
1.1.
1991
3.1.
1991
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1990
1.1.
1988
1.1.
1988
1.1.
1987
1.2.
1987
1.1.
1986
1.1.
1986
1.1.
1986
1.1.
1986
1.2.
1986
2.3.
1985
1.1.
1984
1.1.
1983
1.1.
1983
1.1.
1982
1.1.
1982
1.1.
1979
1.1.
1976
1.1.
1976
  • Leitud 2 kirjet
ProgrammNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusRahastamine kokku
MUUVE430Measurement of airway wall thickness in COPD with identification of new biological markers in airway tissue from COPD patients11.08.200930.09.2011Ruth SepperTallinna Tehnikaülikool; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut 119 994,12 EUR
MTTMTT12Põletiku biomõõdikud01.01.201031.12.2012Thomas FehnigerTallinna Tehnikaülikool, TTÜ Tehnomeedikum287 602,42 EUR
  • Leitud 36 kirjet
PublikatsioonKlassifikaatorFail
Nilsson, C.L.; Berven, F.; Selheim, F.; Liu, H.L.; Moskal, J.R.; Kroes, R.A.; Sulman, E.P.; Conrad, C.A.; Lang, F.F.; Andren, P.E.; Nilsson, A.; Carlsohn, E.; Lilja, H.; Malm, J.; Fenyo, D.; Subramaniyam, D.; Wang, X.D.; Gonzales-Gonzales, M.; Dasilva, N.; Diez, P. ... Marko-Varga, G. (2013). Chromosome 19 Annotations with Disease Speciation: A First Report from the Global Research Consortium. Journal of Proteome Research, 12 (1), 135−150, 10.1021/pr3008607.1.1.
Suits, F.; Fehniger, T.E.; Vegvari, A.; Marko-Varga, G.; Horvatovich, P. (2013). Correlation Queries for Mass Spectrometry Imaging. Analytical Chemistry, 85 (9), 4398−4404, 10.1021/ac303658t.1.1.
Vegvari, A.; Fehniger, T.E.; Rezeli, M.; Laurell, T.; Dome, B.; Jansson, B.; Welinder, C.; Marko-Varga, G. (2013). Experimental Models to Study Drug Distributions in Tissue Using MALDI Mass Spectrometry Imaging. Journal of Proteome Research, 12 (12), 5626−5633, 10.1021/pr400581b.1.1.
Sepper, R.; Prikk, K.; Pilden, B.; Karm, M.; Fehniger, T. (2013). Macrophage Polarization Is Associated With Accelerated MUC5B Expression By BALF Alveolar Macrophages In Smokers&#39; Lung. <i>American Thoracic Society International Conference Abstracts: American Thoracic Society 2013 International Conference, Philadelphia Pennsylvania, May 17-22, 2013 .</i> 5.2.
Sepper, R.; Prikk, K.; Metsis, M.; Sergejeva, S.; Pugatsjova, N.; Bragina, O.; Marran, S.; Fehniger, T. (2012). Mucin5B expression by lung alveolar macrophages is increased in long-term smokers. Journal of Leukocyte Biology, 92 (2), 319−324, 10.1189/jlb.0111047.1.1.
Marko-Varga, G.; Vegvari, A.; Welinder, C.; Lindberg, H.; Rezeli, M.; Edula, G.; Svensson, K.J.; Belting, M.; Laurell, T.; Fehniger, T.E. (2012). Standardization and Utilization of Biobank Resources in Clinical Protein Science with Examples of Emerging Applications. Journal of Proteome Research, 11 (11), 5124−5134, 10.1021/pr300185k.1.1.
Marko-Varga, G.; Végvári, Á.; Rezeli, M.; Prikk, K.; Ross, P.; Dahlbäck, M.; Edula, G.; Sepper, R.; Fehniger, T. (2012). Understanding Drug Uptake and Binding within Targeted Disease Micro-Environments in Patients: A New Tool for Translational Medicine. Clinical and Translational Medicine, 1, 9 pp., 10.1186/2001-1326-1-8.1.2.
Fehniger, T.E.; Marko-Varga, G.A. (2011). Clinical proteomics today. Journal of Proteome Research, 10 (1), 3, 10.1021/pr1012569.1.1.
Fehniger, T.E.; Végvári, A.; Rezeli, M.; Prikk, K; Ross, P.; Dahlbäck, M.; Edula, G.; Sepper, R.; Marko-Varga, G. (2011). Direct Demonstration of Tissue Uptake of an Inhaled Drug: Proof-of-Principle Study Using Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging. Analytical Chemistry, 83 (21), 8329−8336, 10.1021/ac2014349.1.1.
Marko-Varga, G.; Fehniger, T. E.; Rezeli, M.; Döme, B., Laurell, T.; Végvári, A. (2011). Drug localization in different lung cancer phenotypes by MALDI mass spectrometry imaging. Journal of Proteomics, 74 (7), 982−992, 10.1016/j.jprot.2011.03.019.1.1.
Rezeli, M.; Végvári, A.; Fehniger, T.E.; Laurell, T.; Marko-Varga, G. (2011). Moving towards high density clinical signature studies with a human proteome catalogue developing multiplexing mass spectrometry assay panels. Journal of Clinical Bioinformatics, 1, 1−9, 10.1186/2043-9113-1-7.1.1.
Végvár, A.; Welinder, C.; Lindberg, H.; Fehniger, T.E.; Marko-Varga, G. (2011). Biobank resources for future patient care: developments, principles and concepts. Journal of Clinical Bioinformatics, 1, 1−11, 10.1186/2043-9113-1-24.1.2.
Marko-Varga G.A., Végvári Á., Fehniger T.E (2011). A Protein Shake-up. Public Service Review: European Union, 21, 250−252.2.2.
Végvári, A.; Rezeli, M.; Döme, B.; Fehniger, T. E; Marko-Varga, G.. (2011). Translational Science for Targeted Personalized Medicine Treatment. In: S. Sanders (_EditorsAbbr). Selected Presentations from the 2011 Sino-American Symposium on Clinical and Translational Medicine : A Sponsored Supplement To Science (36−37). The American Association for the Advancement of Science.3.2.
Végvári, A.; Fehniger, T. E; Gustavsson, L.; Nilsson, A.; Andrén, P. E; Kenne, K. K; Nilsson, J.; Laurell , T.; Marko-Varga, G. (2010). Essential tactics of tissue preparation and matrix nano-spotting for successful compound imaging mass spectrometry. Journal of Proteomics, pp. 31 , 10.1016/j.jprot.2010.02.021.1.1.
Nilsson A, Fehniger TE, Gustavsson L, Andersson M, Kenne K, Marko-Varga G, Andrén PE. (2010). Fine mapping the spatial distribution and concentration of unlabeled drugs within tissue micro-compartments using imaging mass spectrometry. PLoS ONE, 14 (5), 1−8.1.2.
Fehniger, T. E.; Marko-Varga, G. (2010). Proteomics and Disease Revisited: The Challenge of Providing Proteomic Tools into Clinical Practice. Journal of Proteomic Research, 1−3.1.2.
Svartengren, M; Engström, G.; Anderson, M.; Hallberg, G.; de Verdier, M.G.; Dahlbäck, M.; Lindberg, C.M.; Forsman-Semb, K.; Nihlén, U.; Fehniger, T.E. (2009). Twins studies as a model for studies on the interaction between smoking and genetic factors in the development of chronic bronchitis. <i>Biochemical Society Transactions; 37, Part 4: Conference on Biochemical Basic of Respiratory Disease, Loughborough, England, March 05-06, 2009 .</i> Portland Press Ltd, 814−818.3.1.
Shaker, S.B.; von Wachenfeldt, K.A.; Larsson, S.; Mile, I.; Persdotter, S.; Dahlback, M.; Broberg, P.; Stoel, B.; Bach, K.S.; Hestad, M.; Fehniger, T.E.; Dirksen, A. (2008). Identification of patients with chronic obstructive pulmonary disease (COPD) by measurement of plasma biomarkers. The Clinical Respiratory Journal, 2 (1), 17−25, 10.1111/j.1752-699X.2007.00032.x.1.1.
Plymoth, A.; Löfdahl C.G., Ekberg-Jansson, A., Dahlbäck, M.; Broberg, P.; Foster, M.; Fehniger, T.E.;Marko-Varga, G. (2007). Protein expression patterns associated with progression of chronic obstructive pulmonary disease in bronchoalveolar lavage of smokers. Clinical Chemistry, 53 (4), 636−644, 10.1373/clinchem.2006.076075.1.1.
Plymoth, A.; Yang, Z.; Lofdahl, C.G.; Ekberg-Jansson, A.; Dahlback, M.; Fehniger, T.E.; Marko-Varga, G.; Hancock, W.S. (2006). Rapid proteome analysis of bronchoalveolar lavage samples of lifelong smokers and never-smokers by micro-scale liquid chromatography and mass spectrometry. Clinical Chemistry, 52 (4), 671−679, 10.1373/clinchem.2005.060715.1.1.
Marko-Varga, G.; Lindberg, H., Lofdahl, C.G.; Jonsson, P.; Hansson, L.; Dahlback, M.; Lindquist, E.; Johansson, L.; Foster, M.; Fehniger, T.E. (2005). Discovery of biomarker candidates within disease by protein profiling: principles and concepts. Journal of Proteome Research, 4 (4), 1200−1212, 10.1021/pr050122w.1.1.
Jansson, A.H.; Smailagic, A.; Andersson, A.M.; Zackrisson, C.; Fehniger, T.E.; Stevens, T.R.; Wang, X. (2005). Evaluation of excised lung gas volume measurements in animals with genetic or induced emphysema. Respiratory Physiology &amp; Neurobiology, 150, 240−250, 10.1016/j.resp.2005.04.016.1.1.
Fehniger, T. E.; Laurel , T.; Marko-Varga, G. (2005). Integrating disease knowledge and technology to deliver protein targets and biomarkers into drug discovery projects. Drug Discovery Today : Technologies, 2 (4), 345−351.1.2.
Fehniger, T.E.; Sato-Folatre, J.G.; Malmström, J.; Berglund, M.; Lindberg, C.;, Brange, C.; Lindberg, H.; Marko-Varga, G. (2004). Exploring the context of the lung proteome within the airway mucosa following allergen challenge. Journal of Proteome Research, 3 (2), 307−320, 10.1021/pr0499702.1.1.
  • Leitud 15 kirjet
PealkiriJuhendatavKraadJuhendajaKaitsmise staatusKaitsmise aastaAsutus
A comparison of surface antigens of fourAmare Gessessemagistrikraad (teaduskraad)Thomas FehnigerKaitstud1987Addis Ababa University, Addis Ababa, Ethiopia
A longitudinal study of phagocyte function and viral coinfection in HIV infected individuals.Reinhardt W. FlødoktorikraadThomas FehnigerKaitstud1994University of Bergen, Bergen, Norway
A serological study of human herpervirus type 6 (HHV-6).Ferda Atakermagistrikraad (teaduskraad)Thomas FehnigerKaitstud1993Karolinska Institute, Solna/Huddinge, Sweden
An evaluation of the performance of the biosensor in serotyping HIV-1.Niamh Walshmagistrikraad (teaduskraad)Thomas FehnigerKaitstud1995Karolinska Institute, Solna/Huddinge, Sweden
Clinico-epidemeiological and immunoimmunodiagnosticGenene MengistudoktorikraadThomas FehnigerKaitstud1992Karolinska Institute, Solna/Huddinge, Sweden
EGF is associated with MUC5B expression in human bronchoalveolar lavage fluid alveolar macrophages.magistrikraadKaiu Prikk; Thomas FehnigerKaitstud2012Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
Expression of MMP9, MMP25 and timp1 by alveolar macrophages in lung emphysema and COPD - magistrikraadKaiu Prikk; Thomas FehnigerKaitstud2011Tallinna Tehnikaülikool, TTÜ Tehnomeedikum, Kliinilise meditsiini instituut , Kliinilise medistsiini õppetool
HIV Infection in Ethiopia: Studies of the Infecting Virus and the host responseSeyoum AyehuniedoktorikraadThomas FehnigerKaitstud1992Karolinska Institute,Solna/Huddinge, Sweden
Immunohistochemical characterization of cytokine and chemokine expression profiles in human lung tissueSophie Singbrantmagistrikraad (teaduskraad)Thomas FehnigerKaitstud2003Lund University, Lund, Sweden
Immunohistochemical characterization of inflammation and mucin expression in airway tissue of COPD patientsBelma Jusufovicmagistrikraad (teaduskraad)Thomas FehnigerKaitstud2005Lund University,Lund, Sweden
In vitro and invitro studies of the Human Immunodeficiency Virus (HIV-1) p24 proteinTegest Kebedemagistrikraad (teaduskraad)Thomas FehnigerKaitstud1997Karolinska Institute, Solna/Huddinge, Sweden
Makrofaagide polarisatsiooni muutus suitsetamisest tingitud krooniliste hingamisteede haiguste korral ja seos MUC5B ekspressioonigamagistrikraadKaiu Prikk; Thomas FehnigerKaitstud2013Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Geenitehnoloogia õppetool
Patterns of antibody reactivity with cytomegalovirus antigens by healthy and HIV-1 infected EthiopiansKarima K. Maashomagistrikraad (teaduskraad)Thomas FehnigerKaitstud1991Karolinska Institute, Solna/Huddinge, Sweden
Prevalence of Anti-HIV antibodies in prostitutes and their clients in Addis Ababa EthiopiaSeyoum Ayehuniemagistrikraad (teaduskraad)Thomas FehnigerKaitstud1987Addis Ababa University, Addis Ababa, Ethiopia
Põletiku biomarkerid: suitsetamisest tingitud krooniliste hingamisteede haiguste arengus ja progressioonis - doktorikraadThomas Fehniger; Kaiu PrikkJuhendamiselTallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut
  • Leitud 4 kirjet
TüüpPrioriteedi numberPrioriteedi kuupäevPrioriteedi klassifikaatorPealkiriAutoridFailAsutused
Patentne leiutis0508863.82.04.2005Rahvusvaheline (IPC) ELASTIN PEPTIDE FINGERPRINTS AND ANALYSIS METHODS FOR MMP12 RELATED TO COPDThomas Fehniger; Per Broberg; Stephan Uebel; Gyorgy Marko-VargaASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (All Except US).
Patentne leiutis0500653-1 22.03.2005Rahvusvaheline (IPC)(WO/2006/101436) A PEPTIDE FINGERPRINT FROM THE DE RADATION OF ELASTIN BY HNEThomas Fehniger; PER BROBERG; CLAES LINDBERG; GYÖRGY MARKO VARGA; STEFAN UEBELASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (All Except US).
Patentne leiutis0508863.8 29.04.2005Rahvusvaheline (IPC)(WO/2006/118522) PEPTIDES AS BIOMARKERS OF COPDThomas Fehniger; Per Broberg; György Marko-Varga; Claes LindbergASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (All Except US).
Patentne leiutis0202346-330.07.2002Rahvusvaheline (IPC)WO/2004/011664) PROTEIN OR CARBOHYDRATE PROFILINGThomas Fehniger; György Marko-VargaASTRAZENECA AB [SE/SE]; S-151 85 Södertälje (SE) (