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Olen nõus

Aavo-Valdur Mikelsaar

https://www.etis.ee/CV/Aavo-Valdur_Mikelsaar/est
26.07.1941
737 4211
aavo-valdur.mikelsaar@ut.ee

Teenistuskäik

Töökohad ja ametid
14.06.2012–...   
Tartu Ülikool, Arstiteaduskond, Biomeditsiini instituut, Professor (1,00)
2011–28.02.2011   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, Inimese bioloogia ja geneetika õppetool, juhataja (1,00)
1993–14.06.2012   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, Inimese bioloogia ja geneetika õppetool, Professor (1,00)
1987–2011   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, juhataja (1,00)
01.01.1967–31.12.1970   
NSVL Teaduste Akadeemia Molekulaarbioloogia Instituut, Moskva, aspirant
1965–1987   
Tartu Ülikool, Arstiteaduskond, Üld- ja molekulaarpatoloogia instituut, teadur Tartu ülikoolis 1965-1967; teadur, vanemteadur, laborijuhataja Tartu ülikoolis 1970-1987 (1,00)
 
 
Haridustee
lõpetanud Tartu Ülikooli arstiteaduskonna, arst, 1959; aspirantuur Moskvas Teaduste Akadeemia Molekulaarbioloogia Instituudis 1967-1970; õpingud Viini ülikoolis, 1976-77; Tampere ülikoolis 1988 ja Lübeki Meditsiini ülikoolis, 1993
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2013−...   
TÜ arstiteaduskonna nõukogu liige
2013−...   
TÜ arstiteaduskonna bio-ja siirdemeditsiini instituudi nõukogu liige
2013−...   
Eesti Regeneratiivse Meditsiini Seltsi juhatuse liige
2012−...   
ETAGi programmi TerVE nõukogu liige
2011−...   
TÜ ÜMPI inimese bioloogia ja geneetika õppetooli juhataja alates 2011; juhendanud 4 teaduste kandidaati, 1 magister ja 4 teaduste doktorit
2000−...   
Eesti Inimesegeneetika Ühingu Juhatuse liige
1994−...   
Euroopa Inimesegeneetika Ühingu liige
1987−2011   
Tartu Ülikool, Arstiteaduskond, Üld-ja molekulaarpatoloogia instituut; juhataja

Kvalifikatsioon

Teaduskraadid
Aavo-Valdur Mikelsaar, doktorikraad, 1980, (juh) -, Inimese kromosoomide struktuurne polümorfism, Meditsiinigeneetika Instituut, Moskva.
 
 
Teaduspreemiad ja tunnustused
0, Aavo-Valdur Mikelsaar, Eesti Punase Risti III järgu orden, 2001
 
 
Teadustöö põhisuunad
ETIS VALDKOND: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS VALDKOND: B200 Tsütoloogia, onkoloogia, kantseroloogia
ETIS VALDKOND: 3. Terviseuuringud; 3.1. Biomeditsiin
 
 
Lisainfo
meditsiinikandidaat; bioloogiadoktor
meditsiinikandidaadi kraadi andis välja NSVL MTA, 1970; ja bioloogiadoktorikraadi sama asutus aastal 1980

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2014
Mikelsaar, Ruth; Paves, Heiti; Org, Katrin; Mikelsaar, A.-V. (2014). Chromosome variant 1qh- and its influence on the 3D organization of chromosome 1 heterochromatin in interphase nucleus of patients with endometriosis. Journal of Genetics, 93 (1), 219−223.
5.2.
2014
Mikelsaar, A-V.; Vorobjova, A.; Saag, M.; Mikelsaar, Ruth; Juronen, E. (2014). Expression of mucins and glutathione-S-transferases in dental stem cells isolated from human third molar. Cytochemical study. Abstract of the 12th Annual Meeting of ISSCR (International Society for Stem Cell Research), Vancouver(Canada), 2014. F-L-4021.
5.2.
2013
Mikelsaar1, Aavo-Valdur1 (2013). Diverse functions of titin in non-muscle cells. European J Human Genetics, 21: European Human Genetics Conference 2013, June 8 - 11, Pris France. Nature Publishing Group, 407−407.
5.2.
2013
Mikelsaar, Ruth; Paves, H.; Org, K.; Mikelsaar, A.-V. (2013). Kromosoomvariant 1qh- ja 1. kromosoomi konstitutiivse heterokromatiini 3D-organisatsioon interfaasituumas endometrioosihaigetel (I auhind). Eesti Arst . 18−18. (92,Lisa 2).
5.2.
2013
Mikelsaar, A.-V.; Masso, R.; Masso, M.; Sünter, A.; Mikelsaar, R.; Juronen, E. (2013). Titiin mittelihasrakkudes. Evolutsiooniline analüüs. Eesti Arst, 92. , 37−37. (Lisa 2).
1.1.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, R.; Toomik, P.; Kõiveer, A.; Mikelsaar, I.; Juronen, E. (2012). Epitope of titin a-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells. Cell Division, 7, Art No 21. DOI: 10.1186/1747-1028-7-21.
3.2.
2012
Mikelsaar Aavo-Valdur, Sünter Alar, Toomik Peeter, Karpson Kalmer, Juronen Erkki (2012). Development of new monoclonal antibodies for immunocytochemical characterization of neural stem and differentiated cells. In: Tao Sun (Ed.). Neural Stem Cells (93−118). . University Campus, STeP Ri Slavka Krautzeka 83/A 51000 Rijeka, Croatia: INTECH Open Access Publisher.
5.2.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, Ruth; Toomik, P.; Mikelsaar, I.; Juronen, E. (2012). Evolutionary aspects of centriole associated proteins. Europ J Human Genetics: European Human Genetics Conference 2012 in conj. with the European Meeting on Psychosocial Aspects of Genetics, Nürnberg. , 251.
3.1.
2011
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter; Mikelsaar, Ruth; Juronen, Erkki (2011). New data on the centrosome proteins. Chromosome Research. The Biology of Chromatin and Chromosomes, 19: 8th European Cytogenetics Conference, Altândega Congress & Exhibition Centre, Portugal, 2-5. july 2011. Springer, S199. (Supplement 1).
1.1.
2010
Mikelsaar, A-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Kalev, I.; Kõiveer, A.; Piirsoo, A.; Karpson, K.; Juronen, E. (2010). Titin A-band-specific Monoclonal Antibody Tit1 5H1.1. Cellular Titin As a Centriolar Protein in Non-muscle Cells. Hybridoma, 29 (5), 391−401. DOI: 10.1089/hyb.2009.0116.
5.2.
2010
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Juronen, E. (2010). Titin or a titin-like protein as a human centriolar protein? European Journal of Human Genetics, Supplement 1: European Human Genetics Conference 2010 in conjuction with European Meeting on Psychosocial Aspects of Genetics. Swedish Exhibition & Converence Centre: Nature Publishing Group, 109. (18).
1.1.
2009
Mikelsaar, Aavo-Valdur (2009). Clone F10H2.B3 anti-Ku80. Hybridoma, 28 (2), 155−156. DOI: 10.1089/hyb.2008.0089.
1.1.
2009
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K.; Juronen, E. (2009). New Anti-Ku80 Monoclonal Antibody F10H2.B3 As a Useful Marker for Dividing Cells in Culture. Hybridoma, 107−111. DOI: 10.1089/hyb.2008.0077.
5.1.
2009
Mikelsaar, A.-V. ; Sünter, A.; Toomik, P.; Karpson, K. ; Mikelsaar, R.; Juronen, E.. (2009). The subcellular localisation of Ku80 during mitotic cycle - an immunocytochemical analysis using anti Ku80 Mab F10H2.B3. Chromosome Research, 17: 7th European Cytogenetics Conference, Stockholm, 4-7 July 2009. Ed. Herbert Macgregor. Dordrecht, The Netherlands/Norwel,MA,USA: Springer Heidelberg, S172−S172.
5.2.
2009
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Mikelsar, R.; Kalev, I.; Vaidla, E.; Kõiveer, A.; Piirsoo, A.; Juronen, E. (2009). Tsellulaarne titiin. Uued monokloonsedantikehad Tit1 ja Tit2 2E8.1. (613−613). TÜ arstiteaduskonna päevade teesid, Tartu, 2009. Tartu.
5.2.
2008
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K. (2008). Identification Of New Cell Surface Markers For Human Neural Stem/Progenitor Cells. HUPO 2008 7-th world congress, Amsterdam, 16-20 august. Wiley-V C H Verlag Gmbh.
5.1.
2007
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter (2007). Is titin a human nuclear and chromosomal protein? Chromosome Research: 6th European Cytogenetics Conference (6th ECC). Holland: Springer, 260−260. (15).
6.3.
2007
Mikelsaar, A.-V. (2007). Nobeli auhind füsioloogias ja meditsiinis 2007. Eesti Arst, 86 (12), 863−865.
1.1.
2006
Kalev, I.; Kaasik, A.; Zarkovski, A.; Mikelsaar, AV. (2006). Chemokine receptor CCR5 expression in in vitro differentiating human fetal neural stem/progenitor and glioblastoma cells. Neuroscience Letters, 394 (1), 22−27.
5.2.
2006
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter (2006). Semenogeliin kui teatavat tüüpi neuraalsetest tüvi-eellasrakkudest diferentseerunud ajurakkude (marker?). Eesti Arst. Eesti Arst, 649.
6.7.
2006
Kõks, S.; Kaasik, A.; Ehrlich, K.; Mikelsaar, A-V.; Lainjärv, H.; Rätsep, R.; Metsvaht, T.; Laisk, T. (2006). Arstiteaduskonna aastakonverents II [Videosalvestis] : Uutest arengutest biomeditsiinis.
5.2.
2005
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K.; Piirsoo, A.; Žarkovski, A.; Kaasik, A.; Püssa, T. (2005). Antikeha Y 1C7.A3 antigeen on tõenäoliselt titiini üks isovorm. Eesti Arst, 84 (9): Arstiteaduskonna päevad 2005 Tartus Biomeedikumis 5.-6. oktoober. Tartu: Eesti Arst, 673.
5.2.
2005
Mikelsaar, A.; Sunter, A.; Toomik, P.; Piirsoo, A.; Zharkovski, A.; Kaasik, A.; Pussa, T. (2005). Monoclonal Antibody Y1C7.A3 Probably Recognizes Titin in Neural, Muscle, and Other Nonmuscle Cells. Molecular & Cellular Proteomics, 4: HUPO 4th Annual World Congress. American Society for Biochemistry and Molecular Biology,ASBMB, 190−190.
5.2.
2004
Mikelsaar, Aavo-Valdur; Karpson, Kalmer; Piirsoo, Andres; Toomik, Peeter; Sünter, Alar; Kõiveer, Anu (2004). Antikeha Y 1C7.A3 antigeeni koe- ja arenguspetsiifiline ekspressioon. Eesti Arst, 9, 618.
5.2.
2004
Väli, Marika; Pokk, Paavo; Veromann, Siiri; Mikelsaar, Aavo-Valdur (2004). Etanooli manustamine on katarakti ja glaukoomi reaalne risk. Eesti Arst, 9, 632.
1.1.
2003
Kalev, I.; Osolin, K.; Pärlist, P.; Zilmer, M.; Rajasalu, T.; Podar, T.; Mikelsaar, AV. (2003). CC-chemokine receptor CCR5-del32 mutation as a modifying pathogenetic factor in type I diabetes. Journal of Diabetes and its Complications, 17 (6), 387−391.
5.2.
2003
Mikelsaar, Aavo-Valdur; Karpson, Kalmer; Sünter, Alar (2003). Uued monokloonsed antikehad raku pinna markeritena. Eesti Arst, 9, 641.
1.3.
2002
Kalev, I.; Podar, T.; Oselin, K.; Pärlist, P.; Tasa, G.; Mikelsaar, A. (2002). Kemokiiniretseptori CCR5 geeni polümorfism eestlastel ja mutatsiooni ccr5-delta-32 seos diabeediga. Eesti Arst, 2, 62−69.
5.1.
2002
Kalev, I.; Mikelsaar, A.; Podar, T. (2002). A hypothesis about two kind of function of the CC-chemokine receptor CCR5 in the case of diabetes. European Journal of Human Genetics, 10, 163−163.
5.2.
2002
Sünter, A.; Kostina, O.; Mikelsaar, A.-V. (2002). Transkriptsiooni- ja replikatsiooni/reparatsioonifaktorid närvikoe tüvirakkude ja kasvajarakkude 2D-elektroforegrammil. Eesti Arst, 81 (9), 587.
1.1.
2001
Parlist, P.; Mikelsaar, AV.; Tasa, G.; Beckman, L. (2001). The frequency of C282Y and H63D mutations in Hemochromatosis gene in native Estonians. European Journal of Epidemiology, 17 (3), 213−216.
1.1.
2001
Zerjal, T.; Beckman, L.; Beckman, G.; Mikelsaar, AV.; Krumina, A.; Kucinskas, V.; Hurles, ME.; Tyler-Smith, C. (2001). Geographical, linguistic, and cultural influences on genetic diversity: Y-chromosomal distribution in Northern European populations. Molecular Biology and Evolution, 18 (6), 1077−1087.
1.1.
2001
Tasa, G.; Kals, J.; Muru, K.; Juronen, E.; Piirsoo, A.; Veromann, S.; Janes, S.; Mikelsaar, AV.; Lang, A. (2001). A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. Investigative Ophthalmology & Visual Science, 42 (12), 2762−2764.
1.2.
2001
Kalev, I.; Oselin, K.; Pärlist, P.; Podar, T.; Mikelsaar, A. (2001). CC-chemokine receptor CCR5 gene polymorphism analysis in diabetes Type I and Type II patients in Estonia. European Journal of Human Genetics, 9 (269), 269.
5.2.
2001
Kalev, I.; Oselin, K.; Pärlist, P.; Podar, T.; Mikelsaar, A. - V. (2001). CC - chemokine receptor CCR5 gene polymorphism analysis in diabetes Type I and Type II patients in Estonia. Scandinavian Journal of Immunology, 54: 11 International Congress of Immunology; Stockholm, Sweden; 22 - 27 July 2001. Wiley Online Library, 112−112.
6.3.
2001
Lill, Anne; Mikelsaar, Aavo-Valdur; Metspalu, Andres; Õunap, Katrin (2001). Omapärased lapsed ja sünnieelne diagnostika. Anna, 4, 32−33.
1.1.
2000
Juronen, E.; Tasa, G.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. Experimental Eye Research, 71 (5), 447−452.
1.1.
2000
Kalev, I.; Mikelsaar, AV.; Beckman, L.; Tasa, G.; Parlist, P. (2000). High frequency of the HIV-1 protective CCR5 Delta 32 deletion in native Estonians. European Journal of Epidemiology, 16 (12), 1107−1109.
1.1.
2000
Rosser, ZH.; Zerjal, T.; Hurles, ME.; Adojaan, M.; Alavantic, D.; Kivisild, T.; Mikelsaar, AV.; Parik, J.; Rootsi, S.; Villems, R.; et, al. (2000). Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. The American Journal of Human Genetics, 67 (6), 1526−1543.
1.1.
2000
Juronen, E.; Tasa, T.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. Investigative Ophthalmology & Visual Science, 41 (8), 2262−2267.
5.1.
2000
Mikelsaar, R.; Varb, K.; Lissitsina, J.; Mikelsaar, A.-V. (2000). Extra marker chromosome in an infertile man. European Journal of Human Genetics, 8. 92.
1.1.
1999
Beckman, L.; Sikstrom, C.; Mikelsaar, AV.; Krumina, A.; Kucinskas, V.; Beckman, G. (1999). alpha(1)-antitrypsin (PI) alleles as markers of Westeuropean influence in the Baltic Sea region. Human Heredity, 49 (1), 52−55.
1.1.
1998
Beckman, L.; Sikstrom, C.; Mikelsaar, AV.; Krumina, A.; Ambrasiene, D.; Kucinskas, V.; Beckman, G. (1998). Transferrin variants as markers of migrations and admixture between populations in the Baltic Sea region. Human Heredity, 48 (4), 185−191.
5.1.
1998
Mikelsaar, AV.; Beckman, L.; Tasa, G.; Parlist, P.; Mikelsaar, R. (1998). The frequency of hemochromatosis mutation C282Y in Estonian population. European Journal of Human Genetics, 6, 106−106.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochemistry and Molecular Biology International, 39 (1), 21−29.
1.1.
1996
Tasa, G.; Juronen, E.; Viikmaa, M.; Tiidla, A.; Parlist, P.; Uuskula, M.; Kalev, I.; Mikelsaar, AV. (1996). Distribution of glutathione S-transferase T1 phenotypes in the Estonian population. Gene Geography, 10 (3), 181−189.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Production and characterization of monoclonal antibodies against class theta glutathione S-transferase T1-1. Hybridoma, 15 (1), 77−82.
1.1.
1995
Talvik, T.; Haldre, S.; Soot, A.; Hamarik, M.; Piirsoo, A.; Mikelsaar, AV. (1995). Creatine-kinase isoenzyme bb concentrations in cerebrospinal-fluid in asphyxiated preterm neonates. Acta Paediatrica, 84 (10), 1183−1187.
1.1.
1995
Tasa, G.; Uuskula, M.; Hirvonen, A.; Mikelsaar, AV. (1995). Optimization of pcr to yield successful amplification from heparin-contaminated dna. Methods in Molecular and Cellular Biology, 5 (2), 122−124.
1.1.
1995
Tasa, G.; Juronen, E.; Uuskula, M.; Viikmaa, M.; Mikelsaar, AV. (1995). Phenotyping of glutathione-s-transferase m1 in the Estonian population by elisa using gstm1a and gstm1b specific monoclonal-antibodies. Clinica Chimica Acta, 239 (2), 191−196.
1.1.
1994
Juronen, E.; Tasa, G.; Uuskula, M.; Parik, J.; Mikelsaar, AV. (1994). Allele-specific monoclonal-antibodies against glutathione-s-transferase mu1-1. Hybridoma, 13 (6), 477−484.
1.1.
1994
Mikelsaar, AV.; Tasa, G.; Parlist, P.; Uuskula, M. (1994). Human glutathione-s-transferase gstm1 genetic-polymorphism in Estonia. Human Heredity, 44 (5), 248−251.
1.1.
1992
Sikut, R.; Veromann, S.; Piirsoo, A.; Mikelsaar, AV.; Saar, H.; Reintam, MA. (1992). Ovarian carcinomas express a sperm acrosomal antigen, defined by monoclonal-antibody 9h8. Tumor Biology, 13 (4), 217−225.
1.2.
1992
Mikelsaar, R.; Mikelsaar, A.-V.; Kudrjavtseva, G. (1992). Newborn Screening for Congenital Hypothyroidism in Estonia. Infant Screening, 15 (4), 17−18.
5.2.
1992
Juronen, E; Sikut, R; Veske, A; Mikelsaar, AV (1992). Development of monoclonal antibodies based ELISA methods for thyroxine and thyrotropin iin human sera.
1.1.
1989
Toropova, BG.; Glebov, AV.; Okulov, VB.; Yuronen, EI.; Mikelsaar, AVN. (1989). Factors influencing the human blood-serum myoglobin levels measured by enzyme-immunoassay. Laboratornoe Delo, 12, 54−55.
1.1.
1988
Juronen, EI.; Viikmaa, MH.; Mikelsaar, AVN. (1988). Rapid, simple and sensitive antigen capture elisa for the quantitation of myoglobin using monoclonal-antibodies. Journal of Immunological Methods, 111 (1), 109−115.
1.1.
1988
Yuronen, EI.; Viykman, MG.; Mikelsaar, AVN. (1988). Use of monoclonal-antibodies for quantitative estimation of myoglobin by means of solid-phase immunoenzyme sandwich assay. Voprosy Meditsinskoi Khimii, 34 (4), 132−136.
1.1.
1987
Kivi, S.; Mikelsaar, AV. (1987). C-band polymorphisms in lymphocytes of patients with ovarian or breast adenocarcinoma. Cancer Genetics and Cytogenetics, 28 (1), 77−85.
1.1.
1985
Kivi, S.; Mikelsaar, AV. (1985). Polymorphism of Ag-stained nucleolus organizer regions in lymphocytes of patients with ovarian or breast adenocarcinoma. Human Genetics, 69 (4), 350−352.
1.1.
1984
Mikelsaar, AV.; Schwarzacher, HG. (1984). Clonal inheritance versus variability of ribosomal-RNA gene activity in human-fibroblasts. Human Genetics, 66 (4), 372−372.
5.1.
1984
Piirsoo, AO.; Yuronen, EI.; Parik, YY.; Khaldre, SY.; Mikelsaar, AN.; Viikmaa, MG.; Krinka, A. (1984). Hybridomes producing monoclonal-antibodies for myoglobins and isoenzymes of human bb-creatinephosphokinase. Tsitologiya, 26 (9), 1077−1077.
5.1.
1984
Mikelsaar, AV.; Kivi, S. (1984). Population polymorphism in ag staining of nors. Acta Anatomica, 120, 50−50.
5.1.
1983
Piirsoo, AO.; Viikmaa, MK.; Mikelsaar, AVN.; Khint, RA. (1983). Production by a hybrid, of producers of monoclonal-antibodies to human myoglobin. Tsitologiya, 25 (9), 1090−1091.
5.1.
1981
Mikelsaar, AV.; Ilus, T. (1981). Body size and q-polymorphisms. Clinical Genetics, 19 (6), 524−524.
1.1.
1980
Kivi, S.; Mikelsaar, AV. (1980). Q-band and c-band polymorphisms in patients with ovarian or breast-carcinoma. Human Genetics, 56 (1), 111−114.
1.1.
1980
Kaosaar, M.; Mikelsaar, AV. (1980). Partial short arm deletion of the x-chromosome 46,x,del(x)(qter-]p21-). Human Genetics, 53 (2), 275−277.
1.1.
1979
Mikelsaar, AV.; Ilus, T. (1979). Populational polymorphisms in silver staining of nucleolus organizer regions (nors) in human acrocentric chromosomes. Human Genetics, 51 (3), 281−285.
1.1.
1979
Sigmund, J.; Schwarzacher, HG.; Mikelsaar, AV. (1979). Satellite association frequency and number of nucleoli depend on cell-cycle duration and nor-activity - studies on 1st, 2nd, and 3rd mitoses of lymphocyte-cultures. Human Genetics, 50 (1), 81−91.
1.1.
1978
Mikelsaar, AV.; Schwarzacher, HG. (1978). Comparison of silver staining of nucleolus organizer regions in human lymphocytes and fibroblasts. Human Genetics, 42 (3), 291−299.
1.1.
1978
Mikelsaar, AV.; Ilus, T.; Kivi, S. (1978). Variant chromosome-3 (inv3) in normal newborns and their parents, and in children with mental-retardation. Human Genetics, 41 (1), 109−113.
1.1.
1978
Schwarzacher, HG.; Mikelsaar, AV.; Schnedl, W. (1978). Nature of Ag-staining of nucleolus organizer regions - electron-microscopic and light-microscopic studies on human cells in interphase, mitosis, and meiosis. Cytogenetics and Cell Genetics, 20, 24−39.
3.4.
1978
Schwarzacher, H.G.; Mikelsaar, A.V.; Schnedl, W. (1978). Human nucleolus organizers. Verhandlungen der Anatomischen Gesellschaft, 72, 367−368.
1.1.
1977
Schnedl, W.; Mikelsaar, AV.; Breitenbach, M.; Dann, O. (1977). Dipi and dapi - fluorescence banding with only negligible fading. Human Genetics, 36 (2), 167−172.
1.1.
1977
Mikelsaar, AV.; Schmid, M.; Krone, W.; Schwarzacher, HG.; Schnedl, W. (1977). Frequency of Ag-stained nucleolus organizer regions in acrocentric chromosomes of man. Human Genetics, 37 (1), 73−77.
1.1.
1977
Mikelsaar, AV.; Schwarzacher, HG.; Schnedl, W.; Wagenbichler, P. (1977). Inheritance of Ag-stainability of nucleolus organizer regions - investigations in 7 families with trisomy-21. Human Genetics, 38 (2), 183−188.
1.1.
1977
Schnedl, W.; Breitenbach, M.; Mikelsaar, AV.; Stranzinger, G. (1977). Mithramycin and dipi - pair of fluorochromes specific for gc-rich and at-rich DNA respectively. Human Genetics, 36 (3), 299−305.
1.1.
1976
Kaosaar, ME.; Mikelsaar, AVN.; Talvik, TA.; Mikelsaar, RVA. (1976). Case of trisomy for short arm of chromosome no9 (+9(p)). Human Genetics, 34 (1), 77−80.
1.1.
1975
Mikelsaar, AVN.; Kaosaar, ME.; Tuur, SJ.; Viikmaa, MH.; Talvik, TA.; Laats, J. (1975). Human karyotype polymorphism. 3. Routine and fluorescence microscopic investigation of chromosomes in normal adults and mentally-retarded children. Humangenetik, 26 (1), 1−23.
1.1.
1974
Mikelsaa, AV.; Viikmaa, MH.; Tuur, SJ.; Kaosaar, ME. (1974). Human karyotype polymorphism. 2. Distribution of individuals according to presence of brilliant bands in chromosomes 3,4, and 13 in a normal adult population. Humangenetik, 23 (1), 59−63.
1.1.
1974
Tuur, S.; Kaosaar, M.; Mikelsaar, AV. (1974). 1q+ variants in a normal adult population (one with a pericentric inversion). Humangenetik, 24 (3), 217−220.
1.1.
1973
Mikelsaar, AV.; Lazjuk, GJ.; Lurie, JW.; Tuur, S.; Kaosaar, ME.; Mikelsaar, R.; Loolaid, VE. (1973). A 4p-syndrome. A case report. Humangenetik, 19 (3), 345−347.
1.1.
1973
Kaosaar, ME.; Mikelsaa, AV. (1973). Chromosome investigation in married couples with repeated spontaneous abortions. Humangenetik, 17 (4), 277−283.
1.1.
1973
Kulazhen, VP.; Lazyuk, GI.; Mikelsaa, AV.; Kotovich, LG.; Usoev, SS.; Levchenk, NN. (1973). Heteromorphism of homologs of first chromosome pair in father combined with phenotypical patau syndrome in fetus. Genetika, 9 (3), 138.
1.1.
1973
Mikelsaa, AV.; Tuur, SJ.; Kaosaar, ME. (1973). Human karyotype polymorphism. 1. Routine and fluorescence microscopic investigation of chromosomes in a normal adult population. Humangenetik, 20 (2), 89−101.
1.1.
1973
Talvik, T.; Mikelsaar, AV.; Mikelsaar, R.; Kaosaar, M.; Tuur, S. (1973). Inherited translocations in 2 families (t(14q+ - 10q-) and t(13q- - 21q+)). Humangenetik, 19, 215−226.
1.1.
1972
Mikelsaa, AV. (1972). Application of reflected light in light field microscopy for quantitative autoradiography aimed to examine replication pattern in chromosomes. Tsitologiya, 14 (8), 1061.
1.1.
1972
Talvik, TA.; Mikelsaar, RV.; Mikelsaar, AN. (1972). Family reciprocal translocation between c-group chromosome and d-group chromosome[46, t(cq- - dq+)]. Genetika, 8 (5), 123.
1.1.
1971
Talvik, TA.; Mikelsaar, A-VN.; Mikelsaar, RV-A.; Kask, VA. (1971). A Ring Heterosoma (46,XXr or 46,XYr) in a 2,5 Year Old Girl. Genetika, 7, 136−142.
1.1.
1971
Mikelsaar, A-V.N; Naidionova, MM.; Talvik, T.A.; Mikelsaar, Ruth V.-A. Kaselaid VL; Zucker, EI; Grinberg, KN. (1971). XX/X0 Mosaicism in a new-born female infant with an atypical phenotype. Genetika, 2, 152−160.
1.1.
1971
Mikelsaar, A-VN.; Blumina, MG.; Kuznetsova, LI.; Mikelsaar, RV-A.; Lurie, IV. (1971). A Double Chromosome Aberration 47,XX,21+/47,XXp-q-,21+ in a Girl with Symptoms of Down's and Turner's Syndromes. Genetika, 5, 156−161.
1.1.
1971
Mikelsaar, A-VN.; Blumina, MG.; Kuznetsova, LI.; Mikelsaar, RV. (1971). Children with an XYY sex chromosome set. Genetika, 8, 156−165.
1.1.
1970
Mikelsaa, AV.; Ananjeva, EV.; Gindilis, VM. (1970). Probable pericentric inversion in chromosome no 1 in a female child (46,xx,inv(ip+q-)). Humangenetik, 9 (4), 316.
1.1.
1969
Mikelsaa, AV.; Talvik, TA. (1969). Partial deletion of long arm of chromosome-18. Humangenetik, 7 (4), 359.
6.09.2021

Aavo-Valdur Mikelsaar

https://www.etis.ee/CV/Aavo-Valdur_Mikelsaar/eng
26.07.1941
737 4211
aavo-valdur.mikelsaar@ut.ee

Career

Institutions and positions
14.06.2012–...   
University of Tartu, Faculty of Medicine, Institute of Biomedicine, Professor (1,00)
2011–28.02.2011   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Chair of Human Biology and Genetics, head (1,00)
1993–14.06.2012   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, Chair of Human Biology and Genetics, Professor (1,00)
1987–2011   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, director (1,00)
01.01.1967–31.12.1970   
Institute of Molecular Biology, Academy of Sciences, Moscow, postgraduate student
1965–1987   
University of Tartu, Faculty of Medicine, Departement of General and Molecular Pathology, researcher, head of laboratory , Tartu University, 1965-1967; 1970-1987 (1,00)
 
 
Education
graduated from the Medical Faculty of Tartu University, 1965, physician; postgraduate studium in the Institute of Molecular Biology, Academy of Sciences, Moscow, 1967-1970; studium at University of Vienna 1976-77; studium in Tampere University, 1988; studium in Medical University of Luebeck, 1993
 
 
R&D related managerial and administrative work
2013−...   
member of the Council of the Faculty of Medicine, University of Tartu
2013−...   
member of the Council of the Institute of Biomedicine and Translational Medicine of the University of Tartu
2013−...   
board member of the Estonian Society of Regenerative Medicine
2012−...   
member of the council of program TerVE of Estonian Research Council
2011−...   
head of the chair of human biology and genetics, Tartu University, since 2011; 8 Ph.D. , 1 magister
2000−...   
board member of the Estonian Society of Human genetics
1994−...   
member of European Society of Human Genetics
1987−2011   
University of Tartu, Faculty of Medicine, Department of General and Molecular Pathology; director

Qualifications

Academic degrees
Aavo-Valdur Mikelsaar, Doctor's Degree, 1980, (sup) -, Inimese kromosoomide struktuurne polümorfism, Meditsiinigeneetika Instituut, Moskva.
 
 
Honours & awards
0, Aavo-Valdur Mikelsaar, The IIIrd class Order of the Estonian Red Cross, in 2001
 
 
Fields of research
ETIS RESEARCH FIELD: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS RESEARCH FIELD: B200 Cytology, oncology, cancerology
ETIS RESEARCH FIELD: 3. Health; 3.1. Biomedicine
 
 
Additional information
cand.of medical science and doctor of biological sci. 1970, candidate of medical sciences, Academy of Medical Sciences, Moscow, and doctor of biological sciences, Academy of Medical Sciences, Moscow, 1980

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2014
Mikelsaar, Ruth; Paves, Heiti; Org, Katrin; Mikelsaar, A.-V. (2014). Chromosome variant 1qh- and its influence on the 3D organization of chromosome 1 heterochromatin in interphase nucleus of patients with endometriosis. Journal of Genetics, 93 (1), 219−223.
5.2.
2014
Mikelsaar, A-V.; Vorobjova, A.; Saag, M.; Mikelsaar, Ruth; Juronen, E. (2014). Expression of mucins and glutathione-S-transferases in dental stem cells isolated from human third molar. Cytochemical study. Abstract of the 12th Annual Meeting of ISSCR (International Society for Stem Cell Research), Vancouver(Canada), 2014. F-L-4021.
5.2.
2013
Mikelsaar1, Aavo-Valdur1 (2013). Diverse functions of titin in non-muscle cells. European J Human Genetics, 21: European Human Genetics Conference 2013, June 8 - 11, Pris France. Nature Publishing Group, 407−407.
5.2.
2013
Mikelsaar, Ruth; Paves, H.; Org, K.; Mikelsaar, A.-V. (2013). Kromosoomvariant 1qh- ja 1. kromosoomi konstitutiivse heterokromatiini 3D-organisatsioon interfaasituumas endometrioosihaigetel (I auhind). Eesti Arst . 18−18. (92,Lisa 2).
5.2.
2013
Mikelsaar, A.-V.; Masso, R.; Masso, M.; Sünter, A.; Mikelsaar, R.; Juronen, E. (2013). Titiin mittelihasrakkudes. Evolutsiooniline analüüs. Eesti Arst, 92. , 37−37. (Lisa 2).
1.1.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, R.; Toomik, P.; Kõiveer, A.; Mikelsaar, I.; Juronen, E. (2012). Epitope of titin a-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells. Cell Division, 7, Art No 21. DOI: 10.1186/1747-1028-7-21.
3.2.
2012
Mikelsaar Aavo-Valdur, Sünter Alar, Toomik Peeter, Karpson Kalmer, Juronen Erkki (2012). Development of new monoclonal antibodies for immunocytochemical characterization of neural stem and differentiated cells. In: Tao Sun (Ed.). Neural Stem Cells (93−118). . University Campus, STeP Ri Slavka Krautzeka 83/A 51000 Rijeka, Croatia: INTECH Open Access Publisher.
5.2.
2012
Mikelsaar, A.-V.; Sünter, A.; Mikelsaar, Ruth; Toomik, P.; Mikelsaar, I.; Juronen, E. (2012). Evolutionary aspects of centriole associated proteins. Europ J Human Genetics: European Human Genetics Conference 2012 in conj. with the European Meeting on Psychosocial Aspects of Genetics, Nürnberg. , 251.
3.1.
2011
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter; Mikelsaar, Ruth; Juronen, Erkki (2011). New data on the centrosome proteins. Chromosome Research. The Biology of Chromatin and Chromosomes, 19: 8th European Cytogenetics Conference, Altândega Congress & Exhibition Centre, Portugal, 2-5. july 2011. Springer, S199. (Supplement 1).
1.1.
2010
Mikelsaar, A-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Kalev, I.; Kõiveer, A.; Piirsoo, A.; Karpson, K.; Juronen, E. (2010). Titin A-band-specific Monoclonal Antibody Tit1 5H1.1. Cellular Titin As a Centriolar Protein in Non-muscle Cells. Hybridoma, 29 (5), 391−401. DOI: 10.1089/hyb.2009.0116.
5.2.
2010
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Mikelsaar, R.; Juronen, E. (2010). Titin or a titin-like protein as a human centriolar protein? European Journal of Human Genetics, Supplement 1: European Human Genetics Conference 2010 in conjuction with European Meeting on Psychosocial Aspects of Genetics. Swedish Exhibition & Converence Centre: Nature Publishing Group, 109. (18).
1.1.
2009
Mikelsaar, Aavo-Valdur (2009). Clone F10H2.B3 anti-Ku80. Hybridoma, 28 (2), 155−156. DOI: 10.1089/hyb.2008.0089.
1.1.
2009
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K.; Juronen, E. (2009). New Anti-Ku80 Monoclonal Antibody F10H2.B3 As a Useful Marker for Dividing Cells in Culture. Hybridoma, 107−111. DOI: 10.1089/hyb.2008.0077.
5.1.
2009
Mikelsaar, A.-V. ; Sünter, A.; Toomik, P.; Karpson, K. ; Mikelsaar, R.; Juronen, E.. (2009). The subcellular localisation of Ku80 during mitotic cycle - an immunocytochemical analysis using anti Ku80 Mab F10H2.B3. Chromosome Research, 17: 7th European Cytogenetics Conference, Stockholm, 4-7 July 2009. Ed. Herbert Macgregor. Dordrecht, The Netherlands/Norwel,MA,USA: Springer Heidelberg, S172−S172.
5.2.
2009
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Mikelsar, R.; Kalev, I.; Vaidla, E.; Kõiveer, A.; Piirsoo, A.; Juronen, E. (2009). Tsellulaarne titiin. Uued monokloonsedantikehad Tit1 ja Tit2 2E8.1 [Cellular titin]. (613−613). TÜ arstiteaduskonna päevade teesid, Tartu, 2009. Tartu.
5.2.
2008
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K. (2008). Identification Of New Cell Surface Markers For Human Neural Stem/Progenitor Cells. HUPO 2008 7-th world congress, Amsterdam, 16-20 august. Wiley-V C H Verlag Gmbh.
5.1.
2007
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter (2007). Is titin a human nuclear and chromosomal protein? Chromosome Research: 6th European Cytogenetics Conference (6th ECC). Holland: Springer, 260−260. (15).
6.3.
2007
Mikelsaar, A.-V. (2007). Nobeli auhind füsioloogias ja meditsiinis 2007. Eesti Arst, 86 (12), 863−865.
1.1.
2006
Kalev, I.; Kaasik, A.; Zarkovski, A.; Mikelsaar, AV. (2006). Chemokine receptor CCR5 expression in in vitro differentiating human fetal neural stem/progenitor and glioblastoma cells. Neuroscience Letters, 394 (1), 22−27.
5.2.
2006
Mikelsaar, Aavo-Valdur; Sünter, Alar; Toomik, Peeter (2006). Semenogeliin kui teatavat tüüpi neuraalsetest tüvi-eellasrakkudest diferentseerunud ajurakkude (marker?). Eesti Arst. Eesti Arst, 649.
6.7.
2006
Kõks, S.; Kaasik, A.; Ehrlich, K.; Mikelsaar, A-V.; Lainjärv, H.; Rätsep, R.; Metsvaht, T.; Laisk, T. (2006). Arstiteaduskonna aastakonverents II [Videosalvestis] : Uutest arengutest biomeditsiinis.
5.2.
2005
Mikelsaar, A.-V.; Sünter, A.; Toomik, P.; Karpson, K.; Piirsoo, A.; Žarkovski, A.; Kaasik, A.; Püssa, T. (2005). Antikeha Y 1C7.A3 antigeen on tõenäoliselt titiini üks isovorm. Eesti Arst, 84 (9): Arstiteaduskonna päevad 2005 Tartus Biomeedikumis 5.-6. oktoober. Tartu: Eesti Arst, 673.
5.2.
2005
Mikelsaar, A.; Sunter, A.; Toomik, P.; Piirsoo, A.; Zharkovski, A.; Kaasik, A.; Pussa, T. (2005). Monoclonal Antibody Y1C7.A3 Probably Recognizes Titin in Neural, Muscle, and Other Nonmuscle Cells. Molecular & Cellular Proteomics, 4: HUPO 4th Annual World Congress. American Society for Biochemistry and Molecular Biology,ASBMB, 190−190.
5.2.
2004
Mikelsaar, Aavo-Valdur; Karpson, Kalmer; Piirsoo, Andres; Toomik, Peeter; Sünter, Alar; Kõiveer, Anu (2004). Antikeha Y 1C7.A3 antigeeni koe- ja arenguspetsiifiline ekspressioon. Eesti Arst, 9, 618.
5.2.
2004
Väli, Marika; Pokk, Paavo; Veromann, Siiri; Mikelsaar, Aavo-Valdur (2004). Etanooli manustamine on katarakti ja glaukoomi reaalne risk. Eesti Arst, 9, 632.
1.1.
2003
Kalev, I.; Osolin, K.; Pärlist, P.; Zilmer, M.; Rajasalu, T.; Podar, T.; Mikelsaar, AV. (2003). CC-chemokine receptor CCR5-del32 mutation as a modifying pathogenetic factor in type I diabetes. Journal of Diabetes and its Complications, 17 (6), 387−391.
5.2.
2003
Mikelsaar, Aavo-Valdur; Karpson, Kalmer; Sünter, Alar (2003). Uued monokloonsed antikehad raku pinna markeritena. Eesti Arst, 9, 641.
1.3.
2002
Kalev, I.; Podar, T.; Oselin, K.; Pärlist, P.; Tasa, G.; Mikelsaar, A. (2002). Kemokiiniretseptori CCR5 geeni polümorfism eestlastel ja mutatsiooni ccr5-delta-32 seos diabeediga. Eesti Arst, 2, 62−69.
5.1.
2002
Kalev, I.; Mikelsaar, A.; Podar, T. (2002). A hypothesis about two kind of function of the CC-chemokine receptor CCR5 in the case of diabetes. European Journal of Human Genetics, 10, 163−163.
5.2.
2002
Sünter, A.; Kostina, O.; Mikelsaar, A.-V. (2002). Transkriptsiooni- ja replikatsiooni/reparatsioonifaktorid närvikoe tüvirakkude ja kasvajarakkude 2D-elektroforegrammil. Eesti Arst, 81 (9), 587.
1.1.
2001
Parlist, P.; Mikelsaar, AV.; Tasa, G.; Beckman, L. (2001). The frequency of C282Y and H63D mutations in Hemochromatosis gene in native Estonians. European Journal of Epidemiology, 17 (3), 213−216.
1.1.
2001
Zerjal, T.; Beckman, L.; Beckman, G.; Mikelsaar, AV.; Krumina, A.; Kucinskas, V.; Hurles, ME.; Tyler-Smith, C. (2001). Geographical, linguistic, and cultural influences on genetic diversity: Y-chromosomal distribution in Northern European populations. Molecular Biology and Evolution, 18 (6), 1077−1087.
1.1.
2001
Tasa, G.; Kals, J.; Muru, K.; Juronen, E.; Piirsoo, A.; Veromann, S.; Janes, S.; Mikelsaar, AV.; Lang, A. (2001). A novel mutation in the M1S1 gene responsible for gelatinous droplike corneal dystrophy. Investigative Ophthalmology & Visual Science, 42 (12), 2762−2764.
1.2.
2001
Kalev, I.; Oselin, K.; Pärlist, P.; Podar, T.; Mikelsaar, A. (2001). CC-chemokine receptor CCR5 gene polymorphism analysis in diabetes Type I and Type II patients in Estonia. European Journal of Human Genetics, 9 (269), 269.
5.2.
2001
Kalev, I.; Oselin, K.; Pärlist, P.; Podar, T.; Mikelsaar, A. - V. (2001). CC - chemokine receptor CCR5 gene polymorphism analysis in diabetes Type I and Type II patients in Estonia. Scandinavian Journal of Immunology, 54: 11 International Congress of Immunology; Stockholm, Sweden; 22 - 27 July 2001. Wiley Online Library, 112−112.
6.3.
2001
Lill, Anne; Mikelsaar, Aavo-Valdur; Metspalu, Andres; Õunap, Katrin (2001). Omapärased lapsed ja sünnieelne diagnostika. Anna, 4, 32−33.
1.1.
2000
Juronen, E.; Tasa, G.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. Experimental Eye Research, 71 (5), 447−452.
1.1.
2000
Kalev, I.; Mikelsaar, AV.; Beckman, L.; Tasa, G.; Parlist, P. (2000). High frequency of the HIV-1 protective CCR5 Delta 32 deletion in native Estonians. European Journal of Epidemiology, 16 (12), 1107−1109.
1.1.
2000
Rosser, ZH.; Zerjal, T.; Hurles, ME.; Adojaan, M.; Alavantic, D.; Kivisild, T.; Mikelsaar, AV.; Parik, J.; Rootsi, S.; Villems, R.; et, al. (2000). Y-chromosomal diversity in Europe is clinal and influenced primarily by geography, rather than by language. The American Journal of Human Genetics, 67 (6), 1526−1543.
1.1.
2000
Juronen, E.; Tasa, T.; Veromann, S.; Parts, L.; Tiidla, A.; Pulges, R.; Panov, A.; Soovere, L.; Koka, K.; Mikelsaar, AV. (2000). Polymorphic glutathione S-transferases as genetic risk factors for senile cortical cataract in Estonians. Investigative Ophthalmology & Visual Science, 41 (8), 2262−2267.
5.1.
2000
Mikelsaar, R.; Varb, K.; Lissitsina, J.; Mikelsaar, A.-V. (2000). Extra marker chromosome in an infertile man. European Journal of Human Genetics, 8. 92.
1.1.
1999
Beckman, L.; Sikstrom, C.; Mikelsaar, AV.; Krumina, A.; Kucinskas, V.; Beckman, G. (1999). alpha(1)-antitrypsin (PI) alleles as markers of Westeuropean influence in the Baltic Sea region. Human Heredity, 49 (1), 52−55.
1.1.
1998
Beckman, L.; Sikstrom, C.; Mikelsaar, AV.; Krumina, A.; Ambrasiene, D.; Kucinskas, V.; Beckman, G. (1998). Transferrin variants as markers of migrations and admixture between populations in the Baltic Sea region. Human Heredity, 48 (4), 185−191.
5.1.
1998
Mikelsaar, AV.; Beckman, L.; Tasa, G.; Parlist, P.; Mikelsaar, R. (1998). The frequency of hemochromatosis mutation C282Y in Estonian population. European Journal of Human Genetics, 6, 106−106.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Purification, characterization and tissue distribution of human class theta glutathione S-transferase T1-1. Biochemistry and Molecular Biology International, 39 (1), 21−29.
1.1.
1996
Tasa, G.; Juronen, E.; Viikmaa, M.; Tiidla, A.; Parlist, P.; Uuskula, M.; Kalev, I.; Mikelsaar, AV. (1996). Distribution of glutathione S-transferase T1 phenotypes in the Estonian population. Gene Geography, 10 (3), 181−189.
1.1.
1996
Juronen, E.; Tasa, G.; Uuskula, M.; Pooga, M.; Mikelsaar, AV. (1996). Production and characterization of monoclonal antibodies against class theta glutathione S-transferase T1-1. Hybridoma, 15 (1), 77−82.
1.1.
1995
Talvik, T.; Haldre, S.; Soot, A.; Hamarik, M.; Piirsoo, A.; Mikelsaar, AV. (1995). Creatine-kinase isoenzyme bb concentrations in cerebrospinal-fluid in asphyxiated preterm neonates. Acta Paediatrica, 84 (10), 1183−1187.
1.1.
1995
Tasa, G.; Uuskula, M.; Hirvonen, A.; Mikelsaar, AV. (1995). Optimization of pcr to yield successful amplification from heparin-contaminated dna. Methods in Molecular and Cellular Biology, 5 (2), 122−124.
1.1.
1995
Tasa, G.; Juronen, E.; Uuskula, M.; Viikmaa, M.; Mikelsaar, AV. (1995). Phenotyping of glutathione-s-transferase m1 in the Estonian population by elisa using gstm1a and gstm1b specific monoclonal-antibodies. Clinica Chimica Acta, 239 (2), 191−196.
1.1.
1994
Juronen, E.; Tasa, G.; Uuskula, M.; Parik, J.; Mikelsaar, AV. (1994). Allele-specific monoclonal-antibodies against glutathione-s-transferase mu1-1. Hybridoma, 13 (6), 477−484.
1.1.
1994
Mikelsaar, AV.; Tasa, G.; Parlist, P.; Uuskula, M. (1994). Human glutathione-s-transferase gstm1 genetic-polymorphism in Estonia. Human Heredity, 44 (5), 248−251.
1.1.
1992
Sikut, R.; Veromann, S.; Piirsoo, A.; Mikelsaar, AV.; Saar, H.; Reintam, MA. (1992). Ovarian carcinomas express a sperm acrosomal antigen, defined by monoclonal-antibody 9h8. Tumor Biology, 13 (4), 217−225.
1.2.
1992
Mikelsaar, R.; Mikelsaar, A.-V.; Kudrjavtseva, G. (1992). Newborn Screening for Congenital Hypothyroidism in Estonia. Infant Screening, 15 (4), 17−18.
5.2.
1992
Juronen, E; Sikut, R; Veske, A; Mikelsaar, AV (1992). Development of monoclonal antibodies based ELISA methods for thyroxine and thyrotropin iin human sera.
1.1.
1989
Toropova, BG.; Glebov, AV.; Okulov, VB.; Yuronen, EI.; Mikelsaar, AVN. (1989). Factors influencing the human blood-serum myoglobin levels measured by enzyme-immunoassay. Laboratornoe Delo, 12, 54−55.
1.1.
1988
Juronen, EI.; Viikmaa, MH.; Mikelsaar, AVN. (1988). Rapid, simple and sensitive antigen capture elisa for the quantitation of myoglobin using monoclonal-antibodies. Journal of Immunological Methods, 111 (1), 109−115.
1.1.
1988
Yuronen, EI.; Viykman, MG.; Mikelsaar, AVN. (1988). Use of monoclonal-antibodies for quantitative estimation of myoglobin by means of solid-phase immunoenzyme sandwich assay. Voprosy Meditsinskoi Khimii, 34 (4), 132−136.
1.1.
1987
Kivi, S.; Mikelsaar, AV. (1987). C-band polymorphisms in lymphocytes of patients with ovarian or breast adenocarcinoma. Cancer Genetics and Cytogenetics, 28 (1), 77−85.
1.1.
1985
Kivi, S.; Mikelsaar, AV. (1985). Polymorphism of Ag-stained nucleolus organizer regions in lymphocytes of patients with ovarian or breast adenocarcinoma. Human Genetics, 69 (4), 350−352.
1.1.
1984
Mikelsaar, AV.; Schwarzacher, HG. (1984). Clonal inheritance versus variability of ribosomal-RNA gene activity in human-fibroblasts. Human Genetics, 66 (4), 372−372.
5.1.
1984
Piirsoo, AO.; Yuronen, EI.; Parik, YY.; Khaldre, SY.; Mikelsaar, AN.; Viikmaa, MG.; Krinka, A. (1984). Hybridomes producing monoclonal-antibodies for myoglobins and isoenzymes of human bb-creatinephosphokinase. Tsitologiya, 26 (9), 1077−1077.
5.1.
1984
Mikelsaar, AV.; Kivi, S. (1984). Population polymorphism in ag staining of nors. Acta Anatomica, 120, 50−50.
5.1.
1983
Piirsoo, AO.; Viikmaa, MK.; Mikelsaar, AVN.; Khint, RA. (1983). Production by a hybrid, of producers of monoclonal-antibodies to human myoglobin. Tsitologiya, 25 (9), 1090−1091.
5.1.
1981
Mikelsaar, AV.; Ilus, T. (1981). Body size and q-polymorphisms. Clinical Genetics, 19 (6), 524−524.
1.1.
1980
Kivi, S.; Mikelsaar, AV. (1980). Q-band and c-band polymorphisms in patients with ovarian or breast-carcinoma. Human Genetics, 56 (1), 111−114.
1.1.
1980
Kaosaar, M.; Mikelsaar, AV. (1980). Partial short arm deletion of the x-chromosome 46,x,del(x)(qter-]p21-). Human Genetics, 53 (2), 275−277.
1.1.
1979
Mikelsaar, AV.; Ilus, T. (1979). Populational polymorphisms in silver staining of nucleolus organizer regions (nors) in human acrocentric chromosomes. Human Genetics, 51 (3), 281−285.
1.1.
1979
Sigmund, J.; Schwarzacher, HG.; Mikelsaar, AV. (1979). Satellite association frequency and number of nucleoli depend on cell-cycle duration and nor-activity - studies on 1st, 2nd, and 3rd mitoses of lymphocyte-cultures. Human Genetics, 50 (1), 81−91.
1.1.
1978
Mikelsaar, AV.; Schwarzacher, HG. (1978). Comparison of silver staining of nucleolus organizer regions in human lymphocytes and fibroblasts. Human Genetics, 42 (3), 291−299.
1.1.
1978
Mikelsaar, AV.; Ilus, T.; Kivi, S. (1978). Variant chromosome-3 (inv3) in normal newborns and their parents, and in children with mental-retardation. Human Genetics, 41 (1), 109−113.
1.1.
1978
Schwarzacher, HG.; Mikelsaar, AV.; Schnedl, W. (1978). Nature of Ag-staining of nucleolus organizer regions - electron-microscopic and light-microscopic studies on human cells in interphase, mitosis, and meiosis. Cytogenetics and Cell Genetics, 20, 24−39.
3.4.
1978
Schwarzacher, H.G.; Mikelsaar, A.V.; Schnedl, W. (1978). Human nucleolus organizers. Verhandlungen der Anatomischen Gesellschaft, 72, 367−368.
1.1.
1977
Schnedl, W.; Mikelsaar, AV.; Breitenbach, M.; Dann, O. (1977). Dipi and dapi - fluorescence banding with only negligible fading. Human Genetics, 36 (2), 167−172.
1.1.
1977
Mikelsaar, AV.; Schmid, M.; Krone, W.; Schwarzacher, HG.; Schnedl, W. (1977). Frequency of Ag-stained nucleolus organizer regions in acrocentric chromosomes of man. Human Genetics, 37 (1), 73−77.
1.1.
1977
Mikelsaar, AV.; Schwarzacher, HG.; Schnedl, W.; Wagenbichler, P. (1977). Inheritance of Ag-stainability of nucleolus organizer regions - investigations in 7 families with trisomy-21. Human Genetics, 38 (2), 183−188.
1.1.
1977
Schnedl, W.; Breitenbach, M.; Mikelsaar, AV.; Stranzinger, G. (1977). Mithramycin and dipi - pair of fluorochromes specific for gc-rich and at-rich DNA respectively. Human Genetics, 36 (3), 299−305.
1.1.
1976
Kaosaar, ME.; Mikelsaar, AVN.; Talvik, TA.; Mikelsaar, RVA. (1976). Case of trisomy for short arm of chromosome no9 (+9(p)). Human Genetics, 34 (1), 77−80.
1.1.
1975
Mikelsaar, AVN.; Kaosaar, ME.; Tuur, SJ.; Viikmaa, MH.; Talvik, TA.; Laats, J. (1975). Human karyotype polymorphism. 3. Routine and fluorescence microscopic investigation of chromosomes in normal adults and mentally-retarded children. Humangenetik, 26 (1), 1−23.
1.1.
1974
Mikelsaa, AV.; Viikmaa, MH.; Tuur, SJ.; Kaosaar, ME. (1974). Human karyotype polymorphism. 2. Distribution of individuals according to presence of brilliant bands in chromosomes 3,4, and 13 in a normal adult population. Humangenetik, 23 (1), 59−63.
1.1.
1974
Tuur, S.; Kaosaar, M.; Mikelsaar, AV. (1974). 1q+ variants in a normal adult population (one with a pericentric inversion). Humangenetik, 24 (3), 217−220.
1.1.
1973
Mikelsaar, AV.; Lazjuk, GJ.; Lurie, JW.; Tuur, S.; Kaosaar, ME.; Mikelsaar, R.; Loolaid, VE. (1973). A 4p-syndrome. A case report. Humangenetik, 19 (3), 345−347.
1.1.
1973
Kaosaar, ME.; Mikelsaa, AV. (1973). Chromosome investigation in married couples with repeated spontaneous abortions. Humangenetik, 17 (4), 277−283.
1.1.
1973
Kulazhen, VP.; Lazyuk, GI.; Mikelsaa, AV.; Kotovich, LG.; Usoev, SS.; Levchenk, NN. (1973). Heteromorphism of homologs of first chromosome pair in father combined with phenotypical patau syndrome in fetus. Genetika, 9 (3), 138.
1.1.
1973
Mikelsaa, AV.; Tuur, SJ.; Kaosaar, ME. (1973). Human karyotype polymorphism. 1. Routine and fluorescence microscopic investigation of chromosomes in a normal adult population. Humangenetik, 20 (2), 89−101.
1.1.
1973
Talvik, T.; Mikelsaar, AV.; Mikelsaar, R.; Kaosaar, M.; Tuur, S. (1973). Inherited translocations in 2 families (t(14q+ - 10q-) and t(13q- - 21q+)). Humangenetik, 19, 215−226.
1.1.
1972
Mikelsaa, AV. (1972). Application of reflected light in light field microscopy for quantitative autoradiography aimed to examine replication pattern in chromosomes. Tsitologiya, 14 (8), 1061.
1.1.
1972
Talvik, TA.; Mikelsaar, RV.; Mikelsaar, AN. (1972). Family reciprocal translocation between c-group chromosome and d-group chromosome[46, t(cq- - dq+)]. Genetika, 8 (5), 123.
1.1.
1971
Talvik, TA.; Mikelsaar, A-VN.; Mikelsaar, RV-A.; Kask, VA. (1971). A Ring Heterosoma (46,XXr or 46,XYr) in a 2,5 Year Old Girl. Genetika, 7, 136−142.
1.1.
1971
Mikelsaar, A-V.N; Naidionova, MM.; Talvik, T.A.; Mikelsaar, Ruth V.-A. Kaselaid VL; Zucker, EI; Grinberg, KN. (1971). XX/X0 Mosaicism in a new-born female infant with an atypical phenotype. Genetika, 2, 152−160.
1.1.
1971
Mikelsaar, A-VN.; Blumina, MG.; Kuznetsova, LI.; Mikelsaar, RV-A.; Lurie, IV. (1971). A Double Chromosome Aberration 47,XX,21+/47,XXp-q-,21+ in a Girl with Symptoms of Down's and Turner's Syndromes. Genetika, 5, 156−161.
1.1.
1971
Mikelsaar, A-VN.; Blumina, MG.; Kuznetsova, LI.; Mikelsaar, RV. (1971). Children with an XYY sex chromosome set. Genetika, 8, 156−165.
1.1.
1970
Mikelsaa, AV.; Ananjeva, EV.; Gindilis, VM. (1970). Probable pericentric inversion in chromosome no 1 in a female child (46,xx,inv(ip+q-)). Humangenetik, 9 (4), 316.
1.1.
1969
Mikelsaa, AV.; Talvik, TA. (1969). Partial deletion of long arm of chromosome-18. Humangenetik, 7 (4), 359.
6.09.2021

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