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Lili Azin Milani

https://www.etis.ee/CV/Lili Azin_Milani/est
27.11.1981
737 4039
lili.milani@ut.ee
C-8759-2011
Keeled: rootsi keel - emakeel, inglise keel - väga hea, eesti keel - väga hea, pärsia keel - väga hea, prantsuse keel - hea, vene keel - vähe.

Teenistuskäik

Töökohad ja ametid
2018–...   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, Juhtivteadur (1,00)
10.09.2012–30.11.2012   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, direktori kohusetäitja
2011–31.03.2017   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, Sekveneerimise ja genotüpiseerimise tuumiklabori juhataja (0,20)
2010–2012   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, Järeldoktor (1,00)
01.01.2009–31.12.2010   
Uppsala Ülikool, Lapsepuhkus (0.80)
01.01.2009–31.12.2010   
Uppsala Ülikool, Teadur (0.20)
01.01.2004–31.12.2009   
Uppsala Ülikool, doktorant
01.01.2004–31.12.2004   
Uppsala Ülikooli WCN SNP genotüpiseerimise osakond, laborant
2001–2003   
Tartu Ülikool, Arstiteaduskond, Patoloogilise anatoomia ja kohtuarstiteaduse instituut, Patoloogilise anatoomia õppetool, laborant (0,50)
 
 
Haridustee
2004–2009   
Uppsala ülikool, Meditsiiniliste Teaduste Osakond, Molekulaarne Meditsiin; PhD
2000–2004   
Tartu Ülikool, Molekulaar- ja Rakubioloogia Instituut; BSc
1994–2000   
Tallinna Inglise Kolledz; keskkool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2019−...   
Inimõiguste kaitse, edendamise ja olukorra jälgimise nõukoja liige
2018−...   
Frontiers in Genetics Associate Editor
2016−...   
ETAg-i personaalsete uurimistoetuste ekspertkomisjoni liige
2005−2007   
WCN praktilise kursuse “Applied bioinformatics and methodologies in SNP genotyping” juhendaja, Uppsala Ülikool
2004−2006   
EU/EMBO praktilise kursuse “Advanced techniques in molecular medicine” korraldaja ja juhendaja, Uppsala Ülikool

Kvalifikatsioon

Teaduskraadid
Lili Azin Milani, doktorikraad, 2009, (juh) Ann-Christine Syvänen, Gene Expression in Cancer Cells: Detection of Splice Variants, Allele-specific Expression and DNA Methylation, Uppsala Ülikool.
 
 
Teaduspreemiad ja tunnustused
2019, Lili Azin Milani, Riigi teaduspreemia keemia ja molekulaarbioloogia alal teadustöö „Geneetika- ja genoomikaalased alusuuringud personaalmeditsiini rakendamiseks Eestis“ eest (Esko, Mägi, Fischer, Milani)
2019, Lili Azin Milani, Tartu Ülikooli aumärk
2015, Lili Azin Milani, Vabariigi Presidendi kultuurirahastu noore teadlase preemia
2012, Lili Azin Milani, Eesti Teadusfondi uurimistoetus (4 aastaks)
2011, Lili Azin Milani, MOBILITAS Järeldoktori uurimistoetus (3 aaastaks)
2008, Lili Azin Milani, Anna Lundins stipendium väljapaistvatele doktorantidele
2008, Lili Azin Milani, Keystone Symposia stipendium: Vähi genoomika ja epigenoomika konverentsiks
2008, Lili Azin Milani, Hedströms stipendium väljapaistavatele vanem doktorantidele
2007, Lili Azin Milani, Anna Lundins stipendium väljapaistvatele doktorantidele
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.3. Geneetika
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.3. Geneetika; TÄPSUSTUS: epigeneetika, geeniekspressioon, molekulaarne meditsiin
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; CERCS KLASSIFIKAATOR: B220 Geneetika, tsütogeneetika
 
 
Lisainfo
Osalemine WCN kursustel “Applied bioinformatics and methodologies in SNP genotyping”, Uppsala ja Stockholm, Rootsi 13-19 november, 2004
Osalemine J.D. Terwilliger kursustel “Study design issues for gene mapping in complex traits”, Tartu, Estonia 24-26 mai, 2004
Osalemine CSHL kursustel “Eukaryotic gene expression”, Cold Spring Harbor Laboratory, USA 25. juuni - 15. august, 2005

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2020
Andlauer, Till F. M.; Guzman-Parra, Jose; Streit, Fabian; Strohmaier, Jana; González, Maria José; Gil Flores, Susana; Cabaleiro Fabeiro, Francisco J.; del Río Noriega, Francisco; Perez, Fermin Perez; Haro González, Jesus; Orozco Diaz, Guillermo; de Diego-Otero, Yolanda; Moreno-Küstner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C. ... Rietschel, Marcella (2020). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, online.10.1038/s41380-019-0558-2 [ilmumas].
1.1.
2020
Coleman, Jonathan R. I.; Peyrot, Wouter J.; Purves, Kirstin L.; Davis, Katrina A. S.; Rayner, Christopher; Choi, Shing Wan; Hubel, Christopher; Gaspar, Helena A.; Kan, Carol; Van der Auwera, Sandra; Adams, Mark James; Lyall, Donald M.; Choi, Karmel W.; Dunn, Erin C.; Vassos, Evangelos; Danese, Andrea; Maughan, Barbara; Grabe, Hans J.; Lewis, Cathryn M.; O'Reilly, Paul F. ... Sullivan, Patrick F. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry.10.1038/s41380-019-0546-6.
1.1.
2020
Glanville, Kylie P.; Coleman, Jonathan R., I; Hanscombe, Ken B.; Euesden, Jack; Choi, Shing Wan; Purves, Kirstin L.; Breen, Gerome; Air, Tracy M.; Andlauer, Till F. M.; Baune, Bernhard T.; Binder, Elisabeth B.; Blackwood, Douglas H. R.; Boomsma, Dorret, I; Buttenschon, Henriette N.; Colodro-Conde, Lucia; Dannlowski, Udo; Direk, Nese; Dunn, Erin C.; Forstner, Andreas J.; de Geus, Eco J. C. ... Borglum, Anders D. (2020). Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Biological Psychiatry, 87 (5), 419−430.10.1016/j.biopsych.2019.06.031.
1.1.
2020
Saare, Mario; Tserel, Liina; Haljasmägi, Liis; Taalberg, Egon; Peet, Nadežda; Eimre, Margus; Vetik, Rait; Kingo, Külli; Saks, Kai; Tamm, Riin; Milani, Lili; Kisand, Kai; Peterson, Pärt (2020). Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. Aging Cell, ARTN e13127.10.1111/acel.13127.
1.1.
2020
Whiffin, Nicola; Armean, Irina M; Kleinman, Aaron; Marshall, Jamie L; Minikel, Eric V; Goodrich, Julia K; Quaife, Nicholas M; Cole, Joanne B; Wang, Qingbo; Karczewski, Konrad J; Cummings, Beryl B; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco A S; Merchant, Kalpana M; ,; , ... MacArthur, Daniel G (2020). The effect of LRRK2 loss-of-function variants in humans. Nature Medicine, 26 (6), 869−877.10.1038/s41591-020-0893-5.
1.1.
2020
Huang, Y.; Ollikainen, M.; Muniandy, M.; Zhang, T.; van Dongen, J.; Hao, G.; van der Most, P.J.; Pan, Y.; Pervjakova, N.; Sun, Y.V.; Hui, Q.; Lahti, J.; Fraszczyk, E.; Lu, X.; Sun, D.; Richard, M.A.; Willemsen, G.; Heikkila, K.; Mateo Leach, I.; Mononen, N. ... Wang, X. (2020). Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure. Scientific Reports, 76 (1), 195−205.10.1161/HYPERTENSIONAHA.120.14973.
1.1.
2020
Sulkava, Sonja; Taka, Antti-Mathias; Kantojärvi, Katri; Pölkki, Pirjo; Morales-Muñoz, Isabel; Milani, Lili; Porkka-Heiskanen, Tarja; Saarenpää-Heikkilä, Outi; Kylliäinen, Anneli; Juulia Paavonen, E; Paunio, Tiina (2020). Variation near MTNR1A associates with early development and interacts with seasons. Journal of Sleep Research, e12925−e12925.10.1111/jsr.12925 [ilmumas].
1.1.
2020
Zhou, Yitian; Krebs, Kristi; Milani, Lili; Lauschke, Volker M (2020). Global frequencies of clinically important HLA alleles and their implications for the cost-effectiveness of preemptive pharmacogenetic testing. Clinical pharmacology and therapeutics.10.1002/cpt.1944 [ilmumas].
1.1.
2020
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei ... Fornage, Myriam (2020). Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry.10.1038/s41380-020-0719-3 [ilmumas].
1.1.
2020
Shen, X.; Howard, D.M.; Adams, M.J.; Hill, W.D.; Clarke, T.K.; McIntosh, A.M.; Deary, I.J.; Wray, N.R.; Ripke, S.; Mattheisen, M.; Trzaskowski, M.; Byrne, E.M.; Abdellaoui, A.; Agerbo, E.; Air, T.M.; Andlauer, T.F.M.; Bacanu, S.A.; Bækvad-Hansen, M.; Beekman, A.T.F.; Bigdeli, T.B. ... Owen, M.J. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications, 11 (1).10.1038/s41467-020-16022-0.
1.1.
2020
Bovijn, Jonas; Krebs, Kristi; Chen, Chia-Yen; Boxall, Ruth; Censin, Jenny C; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Laber, Samantha; Millwood, Iona Y; Lin, Kuang; Li, Liming; Chen, Zhengming; Milani, Lili; Smith, George Davey; Walters, Robin G; Mägi, Reedik; Neale, Benjamin M; Lindgren, Cecilia M; Holmes, Michael V (2020). Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics. Science Translational Medicine, 12 (549).10.1126/scitranslmed.aay6570.
1.1.
2020
Huang, Yisong; Ollikainen, Miina; Muniandy, Maheswary; Zhang, Tao; van Dongen, Jenny; Hao, Guang; van Der Most, Peter J.; Pan, Yue; Pervjakova, Natalia; Sun, Yan, V; Hui, Qin; Lahti, Jari; Fraszczyk, Eliza; Lu, Xueling; Sun, Dianjianyi; Richard, Melissa A.; Willemsen, Gonneke; Heikkila, Kauko; Leach, Irene Mateo; Mononen, Nina ... Wang, Xiaoling (2020). Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure. Hypertension, 76 (1), 195−205.10.1161/HYPERTENSIONAHA.120.14973.
1.1.
2020
Pankratov, Vasili; Montinaro, Francesco; Kushniarevich, Alena; Hudjashov, Georgi; Jay, Flora; Saag, Lauri; Flores, Rodrigo; Marnetto, Davide; Seppel, Marten; Kals, Mart; Vosa, Urmo; Taccioli, Cristian; Mols, Mart; Milani, Lili; Aasa, Anto; Lawson, Daniel John; Esko, Tonu; Magi, Reedik; Pagani, Luca; Metspalu, Andres ... Metspalu, Mait (2020). Differences in local population history at the finest level: the case of the Estonian population. European Journal of Human Genetics.10.1038/s41431-020-0699-4 [ilmumas].
3.1.
2020
MORRISON M; TEARE, H; Bertier, G; BUCHANAN, J; Bylstra, Y; Gaff, C; Jackson, L; Kato, K; Kaufmann, E; Kelly, S; Lazaro-Munoz, G; Leitsalu, L; Milani, L; Schaefer, O; Schickhardt, C; Shabani, M; Tutty, E; Winkler, E; WORDSWORTH, S. (2020). Implications of secondary findings for clinical contexts. In: Secondary Findings in Genomic Research (155−201). Academic Press.
3.1.
2020
Morrison, Michael; Teare, Harriet; Bertier, Gabrielle; Buchanan, James; Bylstra, Yasmin; Gaff, Clara; Jackson, Leigh; Kato, Kazuto; Kaufmann, Elke; Kelly, Susan; Lazaro-Munoz, Gabriel; Leitsalu, Liis; Milani, Lili; Schaefer, G. Owen; Schickhardt, Christoph; Shabani, Mahsa; Tutty, Erin; Winkler, Eva C.; Wordsworth, Sarah (2020). Implications of secondary findings for clinical contexts. In: Langanke, M.; Erdmann, P.; Brothers, KB. (Ed.). SECONDARY FINDINGS IN GENOMIC RESEARCH (155−201). LONDON: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD. (Translational and Applied Genomics).10.1016/B978-0-12-816549-2.00008-4.
1.1.
2019
Reisberg, Sulev; Krebs, Kristi; Lepamets, Maarja; Kals, Mart; Mägi, Reedik; Metsalu, Kristjan; Lauschke, Volker M.; Vilo, Jaak; Milani, Lili; (2019). Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions. Genetics in medicine.10.1038/s41436-018-0337-5.
1.1.
2019
Tasa, T,; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 442−454.10.1038/s41431-018-0300-6.
1.1.
2019
Virtanen, V.B.; Salo, P.P.; Cao, J.; Löf-Granström, A.; Milani, L.; Metspalu, A.; Rintala, R.J.; Saarenpää-Heikkilä, O.; Paunio, T.; Wester, T.; Nordenskjöld, A.; Perola, M.; Pakarinen, M.P. (2019). Noncoding RET variants explain the strong association with Hirschsprung disease in patients without rare coding sequence variant. European Journal of Medical Genetics, 62 (4), 229−234.10.1016/j.ejmg.2018.07.019.
1.1.
2019
Kaleviste, Epp; Saare, Mario; Leahy, Timothy Ronan; Bondet, Vincent; Duffy, Darragh; Mogensen, Trine; Jørgensen, Sofie E; Nurm, Helke; Ip, Winnie; Davies, E Graham; Sauer, Sascha; Syvänen, Ann-Christine; Milani, Lili; Peterson, Pärt; Kisand, Kai (2019). Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined. European Journal of Immunology.10.1002/eji.201847955.
1.1.
2019
de Vries, Paul S.; Brown, Michael R.; Bentley, Amy R.; Sung, Yun J.; Winkler, Thomas W.; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T.; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E.; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Richard, Melissa A.; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C. (2019). Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology, 188 (6), 1033−1054.10.1093/aje/kwz005.
1.1.
2019
Timmers, Paul Rhj; Mounier, Ninon; Lall, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew D; Clark, David W; ,; Agbessi, M; Ahsan, H; Alves, I; Andiappan, A; Awadalla, P; Battle, A; Bonder, M J; Boomsma, D; Christiansen, M; Claringbould, A; Deelen, P ... Joshi, Peter K (2019). Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife, 8, e39856.10.7554/eLife.39856.
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648.10.1038/s41588-019-0378-y.
1.1.
2019
Lahtinen, Alexandra; Puttonen, Sampsa; Vanttola, Päivi; Viitasalo, Katriina; Sulkava, Sonja; Pervjakova, Natalia; Joensuu, Anni; Salo, Perttu; Toivola, Auli; Härmä, Mikko; Milani, Lili; Perola, Markus; Paunio, Tiina (2019). A distinctive DNA methylation pattern in insufficient sleep. Scientific Reports, 9, ARTN 1193.10.1038/s41598-018-38009-0.
1.1.
2019
Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Donnelly, Peter; Bates, Lesley; Barroso, Ines; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Deloukas, Panos; Duncanson, Audrey ... Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 180 (3), 223−231.10.1002/ajmg.b.32716.
1.1.
2019
Stahl, Eli A; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, Maciej; Byrne, Enda M; Pers, Tune H; Holmans, Peter A; Richards, Alexander L; Abbott, Liam; Agerbo, Esben ... , (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51 (5), 793−803.10.1038/s41588-019-0397-8.
1.1.
2019
Grove, Jakob; Ripke, Stephan; Als, Thomas D.; Mattheisen, Manuel; Walters, Raymond K.; Won, Hyejung; Pallesen, Jonatan; Agerbo, Esben; Andreassen, Ole A.; Anney, Richard; Awashti, Swapnil; Belliveau, Rich; Bettella, Francesco; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Christensen, Jane H.; Churchhouse, Claire ... Wilson, Catherine H. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431−447.10.1038/s41588-019-0344-8.
1.1.
2019
Foo, Jerome C.; Streit, Fabian; Frank, Josef; Witt, Stephanie H.; Treutlein, Jens; Baune, Bernhard T.; Moebus, Susanne; Joeckel, Karl-Heinz; Forstner, Andreas J.; Noethen, Markus M.; Rietschel, Marcella; Sartorius, Alexander; Kranaster, Laura; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 180 (1), 35−45.10.1002/ajmg.b.32700.
1.1.
2019
Arnau-Soler, Aleix; Macdonald-Dunlop, Erin; Adams, Mark J.; Clarke, Toni-Kim; MacIntyre, Donald J.; Milburn, Keith; Navrady, Lauren; Hayward, Caroline; McIntosh, Andrew M.; Thomson, Pippa A.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Agerbo, Esben; Air, Tracy M.; Andlauer, Till F. M.; Bacanu, Silviu-Alin ... Sullivan, Patrick F. (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9, ARTN 14.10.1038/s41398-018-0360-y.
1.1.
2019
Linner, Richard Karlsson; Biroli, Pietro; Kong, Edward; Meddens, Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Mael; Tino, Stephen P.; Abdellaoui, Abdel; Hammerschlag, Anke R.; Nivard, Michel G.; Okbay, Aysu; Rietveld, Cornelius A.; Timshel, Pascal N.; Trzaskowski, Maciej; de Vlaming, Ronald; Zund, Christian L.; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H. ... Beauchamp, Jonathan P. (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 (2), 245−261.10.1038/s41588-018-0309-3.
1.1.
2019
Huckins, Laura M.; Dobbyn, Amanda; Ruderfer, Douglas M.; Hoffman, Gabriel; Wang, Weiqing; Pardinas, Antonio F.; Rajagopal, Veera M.; Als, Thomas D.; Nguyen, Hoang T.; Girdhar, Kiran; Boocock, James; Roussos, Panos; Fromer, Menachem; Kramer, Robin; Domenici, Enrico; Gamazon, Eric R.; Purcell, Shaun; Demontis, Ditte; Borglum, Anders D.; Walters, James T. R. ... Sullivan, Patrick F. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51 (4), 659−677.10.1038/s41588-019-0364-4.
1.1.
2019
Choi, Karmel W.; Chen, Chia-Yen; Stein, Murray B.; Klimentidis, Yann C.; Wang, Min-Jung; Koenen, Karestan C.; Smoller, Jordan W.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, TracyM.; Andlauer, Till F. M.; Bacanu, Silviu-Alin; Baekvad-Hansen, Marie; Beekman, Aartjan T. F. ... Sullivan, Patrick F. (2019). Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults A 2-Sample Mendelian Randomization Study. JAMA Psychiatry, 76 (4), 399−408.10.1001/jamapsychiatry.2018.4175.
1.1.
2019
Czamara, Darina; Eraslan, Goekcen; Page, Christian M.; Lahti, Jari; Lahti-Pulkkinen, Marius; Hamalainen, Esa; Kajantie, Eero; Laivuori, Hannele; Villa, Pia M.; Reynolds, Rebecca M.; Nystad, Wenche; Haberg, Siri E.; London, Stephanie J.; O'Donnell, Kieran J.; Garg, Elika; Meaney, Michael J.; Entringer, Sonja; Wadhwa, Pathik D.; Buss, Claudia; Jones, Meaghan J. ... Sullivan, Patrick F. (2019). Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns. Nature Communications, 10 (1), 2548.10.1038/s41467-019-10461-0.
1.1.
2019
Musliner, Katherine L.; Mortensen, Preben B.; McGrath, John J.; Suppli, Nis P.; Hougaard, David M.; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Andreassen, Ole; Pedersen, Carsten B.; Pedersen, Marianne G.; Mors, Ole; Nordentoft, Merete; Borglum, Anders D.; Werge, Thomas; Agerbo, Esben; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan ... Sklar, Pamela (2019). Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population. JAMA Psychiatry, 76 (5), 516−525.10.1001/jamapsychiatry.2018.4166.
1.1.
2019
Fang, Hai; Beckmann, Georg; Bountra, Chas; Bowness, Paul; Burgess-Brown, Nicola; Carpenter, Liz; Chen, Liye; Damerell, David; Egner, Ursula; Fujii, Ryo; Howe, Trevor; Jakobsson, Per-Johan; Katopodis, Andreas; Knight, Julian C.; Marsden, Brian D.; De Martino, Julie; Matthias, Gstaiger; McVean, Gilean; Mueller-Fahrnow, Anke; Malarstig, Anders ... Fairfax, Benjamin P. (2019). A genetics-led approach defines the drug target landscape of 30 immune-related traits. Nature Genetics, 51 (7), 1082−1095.10.1038/s41588-019-0456-1.
1.1.
2019
Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W.; Chasman, Daniel, I; Bentley, Amy R.; Kraja, Aldi T.; Ntalla, Ioanna; Warren, Helen R.; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K.; Brown, Michael R.; Aschard, Hugues; Feitosa, Mary F.; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan ... Morrison, Alanna C. (2019). A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Human Molecular Genetics, 28 (15), 2615−2633.10.1093/hmg/ddz070.
1.1.
2019
Krebs, Kristi; Milani, Lili (2019). Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good. Human Genomics, 13 (1), 39−39.10.1186/s40246-019-0229-z.
1.1.
2019
Clark, David W.; Okada, Yukinori; Moore, Kristjan H. S.; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L. K.; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M. ... Wilson, James F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, ARTN 4957.10.1038/s41467-019-12283-6.
1.1.
2019
Polimanti, Renato; Peterson, Roseann E.; Ong, Jue-Sheng; MacGregor, Stuart; Edwards, Alexis C.; Clarke, Toni-Kim; Frank, Josef; Gerring, Zachary; Gillespie, Nathan A.; Lind, Penelope A.; Maes, Hermine H.; Martin, Nicholas G.; Mbarek, Hamdi; Medland, Sarah E.; Streit, Fabian; Agrawal, Arpana; Edenberg, Howard J.; Kendler, Kenneth S.; Lewis, Cathryn M.; Sullivan, Patrick F. ... Neale, Benjamin M. (2019). Evidence of causal effect of major depression on alcohol dependence: findings from the psychiatric genomics consortium. Psychological Medicine, 49 (7), 1218−1226.10.1017/S0033291719000667.
1.1.
2019
Barbu, Miruna C.; Zeng, Yanni; Shen, Xueyi; Cox, Simon R.; Clarke, Toni-Kim; Gibson, Jude; Adams, Mark J.; Johnstone, Mandy; Haley, Chris S.; Lawrie, Stephen M.; Deary, Ian J.; McIntosh, Andrew M.; Whalley, Heather C.; Agee, Michelle; Alipanahi, Babak; Auton, Adam; Bell, RobertK; Bryc, Katarzyna; Elson, Sarah L.; Fontanillas, Pierre ... Sullivan, Patrick F. (2019). Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Biological Psychiatry-cognitive Neuroscience and Neuroimaging, 4 (1), 91−100.10.1016/j.bpsc.2018.07.006.
6.6.
2019
Milani, Lili (2019). MIS SIND NÄRVI AJAB | Arstid ei tea midagi! Perefoorumid on nõmedad? Vale puha. Delfi - Eesti Päevaleht.
6.8.
2019
Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P; Esko, Tõnu; Giri, Ayush; Graff, Mariaelisa; Guo, Xiuqing; Hendricks, Audrey E; Karaderi, Tugce; Lempradl, Adelheid; Locke, Adam E; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; Young, Kristin L; Alfred, Tamuno ... Loos, Ruth J F (2019). Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, 51 (7), 1191−1192.10.1038/s41588-019-0447-2.
1.1.
2018
Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
1.1.
2018
Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
1.1.
2018
Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. Jornal Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
1.1.
2018
Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLOS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
1.1.
2018
Lauschke, Volker M.; Milani, Lili; Ingelman-Sundberg, Magnus (2018). Pharmacogenomic Biomarkers for Improved Drug Therapy- Recent Progress and Future Developments. Aaps Journal, 20 (1), UNSP 4.10.1208/s12248-017-0161-x.
1.1.
2018
Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M.; Andlauer, Till M. F.; Bacanu, Silviu-Alin; Baekvad-Hansen, Marie; Beekman, Aartjan F. T.; Bigdeli, Tim B.; Binder, Elisabeth B.; Blackwood, Douglas R. H.; Bryois, Julien; Buttenschon, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668−684.10.1038/s41588-018-0090-3.
1.1.
2018
Wahl, Annika; Kasela, Silva; Carnero-Montoro, Elena; van Iterson, Maarten; Stambuk, Jerko; Sharma, Sapna; van den Akker, Erik; Klaric, Lucija; Benedetti, Elisa; Razdorov, Genadij; Trbojevic-Akmacic, Irena; Vuckovic, Frano; Ugrina, Ivo; Beekman, Marian; Deelen, Joris; van Heemst, Diana; Heijmans, Bastiaan T.; Wuhrer, Manfred; Plomp, Rosina; Keser, Toma ... Gieger, Christian (2018). IgG glycosylation and DNA methylation are interconnected with smoking. Biochimica et Biophysica Acta - General Subjects, 1862 (3), 637−648.10.1016/j.bbagen.2017.10.012.
1.1.
2018
Lu, Y.; Pouget, J. G.; Andreassen, O. A.; Djurovic, S.; Esko, T.; Hultman, C. M.; Metspalu, A.; Milani, L.; Werge, T.; Sullivan, P. F. (2018). Genetic risk scores and family history as predictors of schizophrenia in Nordic registers. Psychological Medicine, 48 (7), 1201−1208.10.1017/S0033291717002665.
1.1.
2018
Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alexander W.; Ori, Anil P. S.; Loohuis, Loes M. Olde; Domenici, Enrico; Di Florio, Arianna; Papiol, Sergi; Kalman, Janos L.; Trubetskoy, Vassily; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Albani, Diego ... Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. Cell, 173 (7), ARTN 1715.e16−1732.10.1016/j.cell.2018.05.046.
1.1.
2018
de Jong, Simone; Abdalla Diniz, Mateus Jose; Saloma, Andiara; Gadelha, Ary; Santoro, Marcos L.; Ota, Vanessa K.; Noto, Cristiano; Curtis, Charlesg; Newhouse, Stephen J.; Patel, Hamel; Hall, Lynsey S.; O'Reilly, Paul F.; Belangero, Sintia, I; Bressan, Rodrigo A.; Breen, Gerome; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M. ... Shi, Jianxin (2018). Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder. Communications Biology, 1, ARTN 163.10.1038/s42003-018-0155-y.
1.1.
2018
Evangelou, Evangelos; Warren, Helen R.; Mosen-Ansorena, David; Mifsu, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrer, Claudia P.; Karaman, Ibrahim; Ng, FuLiang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N.; Giri, Ayush; Edwards, Digna R. Velez; Sun, Yan, V; Cho, Kelly; Gaziano, J. Michael ... Caulfield, Mark J. (2018). Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (10), 1412−1429.10.1038/s41588-018-0205-x.
1.1.
2018
Turcot, Valerie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.; Bradfield, Jonathan P.; Esko, Tõnu; Giri, Ayush; Graff, Mariaelisa; Guo, Xiuqing; Hendricks, Audrey E.; Karaderi, Tugce; Lempradl, Adelheid; Locke, Adam E.; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; Young, Kristin L.; Alfred, Tamuno ... Loos, Ruth J. F. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, 50 (1), 26−45.10.1038/s41588-017-0011-x.
1.1.
2018
Parmar, Priyanka; Lowry, Estelle; Cugliari, Giovanni; Suderman, Matthew; Wilson, Rory; Karhunen, Ville; Andrew, Toby; Wiklund, Petri; Wielscher, Matthias; Guarrera, Simonetta; Teumer, Alexander; Lehne, Benjamin; Milani, Lili; de Klein, Niek; Mishra, Pashupati P.; Melton, Phillip E.; Mandaviya, Pooja R.; Kasela, Silva; Nano, Jana; Zhang, Weihua ... Sebert, Sylvain (2018). Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults. EBioMedicine, 38, 206−216.10.1016/j.ebiom.2018.10.066.
6.3.
2018
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2018). Mis tunne on olla (noor) naisteadlane? Sirp, 8−9.
6.3.
2018
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2018). Kolm ettepanekut Eesti teaduse jätkusuutlikkuse tagamiseks. Postimees, 11.04.2018.
6.8.
2018
Turcot, Valerie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.; Bradfield, Jonathan P.; Esko, Tonu; Giri, Ayush; Graff, Mariaelisa; Guo, Xiuqing; Hendricks, Audrey E.; Karaderi, Tugce; Lempradl, Adelheid; Locke, Adam E.; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; Young, Kristin L.; Alfred, Tamuno ... Loos, Ruth J. F. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 26, 2018). Nature Genetics, 50 (5), 766−767.10.1038/s41588-018-0082-3.
6.8.
2018
Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez ... McCarthy, Mark I (2018). Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 5, 180002−180002.10.1038/sdata.2018.2.
6.8.
2018
Evangelou, Evangelos; Warren, Helen R; Mosen-Ansorena, David; Mifsud, Borbala; Pazoki, Raha; Gao, He; Ntritsos, Georgios; Dimou, Niki; Cabrera, Claudia P; Karaman, Ibrahim; Ng, Fu Liang; Evangelou, Marina; Witkowska, Katarzyna; Tzanis, Evan; Hellwege, Jacklyn N; Giri, Ayush; Velez Edwards, Digna R; Sun, Yan V; Cho, Kelly; Gaziano, J Michael ... Caulfield, Mark J (2018). Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50 (12), 1755−1755.10.1038/s41588-018-0297-3.
6.8.
2018
Turcot, Valerie; Lu, Yingchang; Highland, Heather M.; Schurmann, Claudia; Justice, Anne E.; Fine, Rebecca S.; Bradfield, Jonathan P.; Esko, Tonu; Giri, Ayush; Graff, Mariaelisa; Guo, Xiuqing; Hendricks, Audrey E.; Karaderi, Tugce; Lempradl, Adelheid; Locke, Adam E.; Mahajan, Anubha; Marouli, Eirini; Sivapalaratnam, Suthesh; Young, Kristin L.; Alfred, Tamuno ... Loos, Ruth J. F. (2018). Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity (vol 50, pg 765, 2017). Nature Genetics, 50 (5), 765−766.10.1038/s41588-018-0050-y.
1.1.
2017
Wahl, Simone; Drong, Alexander; Lehne, Benjamin; Loh, Marie; Scott, William R; Kunze, Sonja; Tsai, Pei-Chien; Ried, Janina S; Zhang, Weihua; Yang, Youwen; Tan, Sili; Fiorito, Giovanni; Franke, Lude; Guarrera, Simonetta; Kasela, Silva; Kriebel, Jennifer; Richmond, Rebecca C; Adamo, Marco; Afzal, Uzma; Ala-Korpela, Mika ... Chambers, John C (2017). Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541 (7635), 81−86.10.1038/nature20784.
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2017
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201.10.1038/mp.2016.71.
1.1.
2017
Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, Tasa T, Metspalu A, Milani L, Peterson P. (2017). DNA breaks and chromatin structural changes enhance the transcription of Autoimmune Regulator target genes. Journal of Biological Chemistry, 292 (16), 6542−6554.10.1074/jbc.M116.764704.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 114 (3), E327−E336.10.1073/pnas.1619052114.
1.1.
2017
R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical pharmacology and therapeutics, 101 (5), 684−695.10.1002/cpt.540.
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2017
Nath, Artika P.; Ritchie, Scott C.; Byars, Sean G.; Fearnley, Liam G.; Havulinna, Aki S.; Joensuu, Anni; Kangas, Antti J.; Soininen, Pasi; Wennerstrom, Annika; Milani, Lili; Metspalu, Andres; Mannisto, Satu; Wurtz, Peter; Kettunen, Johannes; Raitoharju, Emma; Kahonen, Mika; Juonala, Markus; Palotie, Aarno; Ala-Korpela, Mika; Ripatti, Samuli ... Inouye, Michael (2017). An interaction map of circulating metabolites, immune gene networks, and their genetic regulation. Genome Biology, 18, ARTN 146.10.1186/s13059-017-1279-y.
1.1.
2017
Robinson, Matthew R.; English, Geoffrey; Moser, Gerhard; Lloyd-Jones, Luke R.; Triplett, Marcus A.; Zhu, Zhihong; Nolte, Ilja M.; van Vliet-Ostaptchouk, Jana V.; Snieder, Harold; Esko, Tonu; Milani, Lili; Magi, Reedik; Metspalu, Andres; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Ingelsson, Erik; Johannesson, Magnus; Yang, Jian; Cesarini, David; Visscher, Peter M. (2017). Genotype-covariate interaction effects and the heritability of adult body mass index. Nature Genetics, 49 (8), 1174−1186.10.1038/ng.3912.
1.1.
2017
Mihailov, E.; Nikopensius, T.; Reigo, A.; Nikkolo, C.; Kals, M.; Aruaas, K.; Milani, L.; Seepter, H.; Metspalu, A. (2017). Whole-exome sequencing identifies a potential TTN mutation in a multiplex family with inguinal hernia. Hernia, 21 (1), 95−100.10.1007/s10029-016-1491-9.
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2017
Manning, Alisa; Highland, Heather M.; Gasser, Jessica; Sim, Xueling; Tukiainen, Taru; Fontanillas, Pierre; Grarup, Niels; Rivas, Manuel A.; Mahajan, Anubha; Locke, Adam E.; Cingolani, Pablo; Pers, Tune H.; Vinuela, Ana; Brown, Andrew A.; Wu, Ying; Flannick, Jason; Fuchsberger, Christian; Gamazon, Eric R.; Gaulton, Kyle J.; Im, Hae Kyung ... Lindgren, Cecilia M. (2017). A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes, 66 (7), 2019−2032.10.2337/db16-1329.
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2017
Marshall, Christian R.; Marshall, Christian R.; Howrigan, Daniel P.; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S.; Antaki, Danny; Shetty, Aniket; Holmans, Peter A.; Pinto, Dalila; Gujral, Madhusudan; Brandler, William M.; Malhotra, Dheeraj; Wang, Zhouzhi; Fajarado, Karin V. Fuentes; Maile, Michelle S.; Ripke, Stephan; Agartz, Ingrid; Albus, Margot ... Sebat, Jonathan (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics, 1, 27−35.10.1038/ng.3725.
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2017
Mandaviya PR, Aïssi D, Dekkers KF, Joehanes R, Kasela S, Truong V, Stolk L, Heemst DV, Ikram MA, Lindemans J, Slagboom PE, Trégouët DA, Uitterlinden AG, Wei C, Wells P, Gagnon F, van Greevenbroek MM, Heijmans BT, Milani L, Morange PE, van Meurs JB, Heil SG; BIOS Consortium. (2017). Homocysteine levels associate with subtle changes in leukocyte DNA methylation: an epigenome-wide analysis. Epigenomics, 9 (11), 1403−1422.10.2217/epi-2017-0038.
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Kasela, Silva; Kisand, Kai; Tserel, Liina; Kaleviste, Epp; Remm, Anu; Fischer, Krista; Esko, Tõnu; Westra, Harm-Jan; Fairfax, Benjamin P; Makino, Seiko; Knight, Julian C; Franke, Lude; Metspalu, Andres; Peterson, Pärt; Milani, Lili (2017). Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells. PLOS Genetics, 13 (3, 3), ARTN e1006643.10.1371/journal.pgen.1006643.
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Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M.; Agarwala, Vineeta; Gaulton, Kyle J.; Caulkins, Lizz; Koesterer, Ryan; Ma, Clement; Moutsianas, Loukas; McCarthy, Davis J.; Rivas, Manuel A.; Perry, John R. B.; Sim, Xueling; Blackwell, Thomas W.; Robertson, Neil R.; Rayner, N. William; Cingolani, Pablo; Locke, Adam E.; Tajes, Juan Fernandez ... McCarthy, Mark I. (2017). Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, ARTN 170179.10.1038/sdata.2017.179.
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2017
Day, Felix R.; Thompson, Deborah J.; Helgason, Hannes; Chasman, Daniel I.; Finucane, Hilary; Sulem, Patrick; Ruth, Katherine S.; Whalen, Sean; Sarkar, Abhishek K.; Albrecht, Eva; Altmaier, Elisabeth; Amini, Marzyeh; Barbieri, Caterina M.; Boutin, Thibaud; Campbell, Archie; Demerath, Ellen; Giri, Ayush; He, Chunyan; Hottenga, Jouke J.; Karlsson, Robert ... Perry, John R. B. (2017). Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nature Genetics, 49 (6), 834−845.10.1038/ng.3841.
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Linner, R. Karlsson; Marioni, R. E.; Rietveld, C. A.; Simpkin, A. J.; Davies, N. M.; Watanabe, K.; Armstrong, N. J.; Auro, K.; Baumbach, C.; Bonder, M. J.; Buchwald, J.; Fiorito, G.; Ismail, K.; Iurato, S.; Joensuu, A.; Karell, P.; Kasela, S.; Lahti, J.; Mcrae, A. F.; Mandaviya, P. R. ... Benjamin, D. J. (2017). An epigenome-wide association study meta-analysis of educational attainment. Molecular Psychiatry, 22 (12), 1680−1690.10.1038/mp.2017.210.
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Gupta, R; Qaiser, B; He, L; Hiekkalinna, T S; Zheutlin, A B; Therman, S; Ollikainen, M; Ripatti, S; Perola, M; Salomaa, V; Milani, L; Cannon, T D; Madden, P A F; Korhonen, T; Kaprio, J; Loukola, A (2017). Neuregulin signaling pathway in smoking behavior. Translational Psychiatry, 7 (8), e1212−e1212.10.1038/tp.2017.183.
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Kantojärvi, Katri; Liuhanen, Johanna; Saarenpää-Heikkilä, Outi; Satomaa, Anna-Liisa; Kylliäinen, Anneli; Pölkki, Pirjo; Jaatela, Julia; Toivola, Auli; Milani, Lili; Himanen, Sari-Leena; Porkka-Heiskanen, Tarja; Paavonen, Juulia; Paunio, Tiina (2017). Variants in calcium voltage-gated channel subunit Alpha1 C-gene (CACNA1C) are associated with sleep latency in infants. PLOS ONE, 12 (8), e0180652−e0180652.10.1371/journal.pone.0180652.
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Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark D.W., Nutile T., Barnes C.L.K., Timmers P.R.H.J., Shen X., Gandin I., McDaid A.F., Hansen T.F., Gordon S.D., Giulianini F., Boutin T.S., Abdellaoui A., Zhao W., Medina-Gomez C., Bartz T.M., Trompet S., Lange L.A., Raffield L., van der Spek A.,/.../,Bertram L., Pendleton N., Kardia S.L.R., Ciullo M., Becker D.M., Wong A., Psaty B.M., van Duijn C.M., Wilson J.G., Jukema J.W., Kiemeney L., Uitterlinden A.G, Franceschini N., North K.E., Weir D.R., Metspalu A., Boomsma D.I., Hayward C., Chasman D., Martin N.G., Sattar N., Campbell H., Esko T., Kutalik Z., Wilson J.F. (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, 910.10.1038/s41467-017-00934-5.
1.1.
2017
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, Robertson NR, Rayner NW, Cingolani P, Locke AE, Tajes JF, Highland HM, Dupuis J, Chines PS, Lindgren CM, Hartl C, Jackson AU, Chen H, Huyghe JR, van de Bunt M, Pearson RD, Kumar A, Müller-Nurasyid M, Grarup N, Stringham HM, Gamazon ER, Lee J, Chen Y, Scott RA, Below JE, Chen P, Huang J, Go MJ, Stitzel ML, Pasko D, Parker SCJ, Varga TV, Green T, Beer NL, Day-Williams AG, Ferreira T, Fingerlin T, Horikoshi M, Hu C, Huh I, Ikram MK, Kim BJ, Kim Y, Kim YJ, Kwon MS, Lee J, Lee S, Lin KH, Maxwell TJ, Nagai Y, Wang X, Welch RP, Yoon J, Zhang W, Barzilai N, Voight BF, Han BG, Jenkinson CP, Kuulasmaa T, Kuusisto J, Manning A, Ng MCY, Palmer ND, Balkau B, Stančáková A, Abboud HE, Boeing H, Giedraitis V, Prabhakaran D, Gottesman O, Scott J, Carey J, Kwan P, Grant G, Smith JD, Neale BM, Purcell S, Butterworth AS, Howson JMM, Lee HM, Lu Y, Kwak SH, Zhao W, Danesh J, Lam VKL, Park KS, Saleheen D, So WY, Tam CHT, Afzal U, Aguilar D, Arya R, Aung T, Chan E, Navarro C, Cheng CY, Palli D, Correa A, Curran JE, Rybin D, Farook VS, Fowler SP, Freedman BI, Griswold M, Hale DE, Hicks PJ, Khor CC, Kumar S, Lehne B, Thuillier D, Lim WY, Liu J, Loh M, Musani SK, Puppala S, Scott WR, Yengo L, Tan ST, Taylor HA, Thameem F, Wilson G, Wong TY, Njølstad PR, Levy JC, Mangino M, Bonnycastle LL, Schwarzmayr T, Fadista J, Surdulescu GL, Herder C, Groves CJ, Wieland T, Bork-Jensen J, Brandslund I, Christensen C, Koistinen HA, Doney ASF, Kinnunen L, Esko T, Farmer AJ, Hakaste L, Hodgkiss D, Kravic J, Lyssenko V, Hollensted M, Jørgensen ME, Jørgensen T, Ladenvall C, Justesen JM, Käräjämäki A, Kriebel J, Rathmann W, Lannfelt L, Lauritzen T, Narisu N, Linneberg A, Melander O, Milani L, Neville M, Orho-Melander M, Qi L, Qi Q, Roden M, Rolandsson O, Swift A, Rosengren AH, Stirrups K, Wood AR, Mihailov E, Blancher C, Carneiro MO, Maguire J, Poplin R, Shakir K, Fennell T, DePristo M, de Angelis MH, Deloukas P, Gjesing AP, Jun G, Nilsson P, Murphy J, Onofrio R, Thorand B, Hansen T, Meisinger C, Hu FB, Isomaa B, Karpe F, Liang L, Peters A, Huth C, O'Rahilly SP, Palmer CNA, Pedersen O, Rauramaa R, Tuomilehto J, Salomaa V, Watanabe RM, Syvänen AC, Bergman RN, Bharadwaj D, Bottinger EP, Cho YS, Chandak GR, Chan JC, Chia KS, Daly MJ, Ebrahim SB, Langenberg C, Elliott P, Jablonski KA, Lehman DM, Jia W, Ma RCW, Pollin TI, Sandhu M, Tandon N, Froguel P, Barroso I, Teo YY, Zeggini E, Loos RJF, Small KS, Ried JS, DeFronzo RA, Grallert H, Glaser B, Metspalu A, Wareham NJ, Walker M, Banks E, Gieger C, Ingelsson E, Im HK, Illig T, Franks PW, Buck G, Trakalo J, Buck D, Prokopenko I, Mägi R, Lind L, Farjoun Y, Owen KR, Gloyn AL, Strauch K, Tuomi T, Kooner JS, Lee JY, Park T, Donnelly P, Morris AD, Hattersley AT, Bowden DW, Collins FS, Atzmon G, Chambers JC, Spector TD, Laakso M, Strom TM, Bell GI, Blangero J, Duggirala R, Tai ES, McVean G, Hanis CL, Wilson JG, Seielstad M, Frayling TM, Meigs JB, Cox NJ, Sladek R, Lander ES, Gabriel S, Mohlke KL, Meitinger T, Groop L, Abecasis G, Scott LJ, Morris AP, Kang HM, Altshuler D, Burtt NP, Florez JC, Boehnke M, McCarthy MI. (2017). Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data, 4, 170179.10.1038/sdata.2017.179.
6.3.
2017
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Teadlaste koostöö ettevõtetega – kellele seda vaja on? Sirp, 37−37.
6.3.
2017
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Põlevkivist elektri tootmisest on kujunemas piinlik igand. Sirp, 28−29.
6.3.
2017
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Teadus kui haridusuuenduse toetuspunkt, vundament, vaade ja garantii. Sirp, 34−35.
6.3.
2017
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Teadlaste otselepingud ja vaesus. Sirp, 33−35.
6.3.
2017
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Kuhu viib teadlaste karjääriredel? Sirp, 7−8.
6.8.
2017
Lokk, Kaie; Vooder, Tõnu; Kolde, Raivo; Välk, Kristjan; Võsa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tõnisson, Neeme (2017). Correction: Methylation Markers of Early-Stage Non-Small Cell Lung Cancer. PLOS ONE, 12 (1), e0170833−e0170833.10.1371/journal.pone.0170833.
6.8.
2017
Lokk, Kaie; Vooder, Tonu; Kolde, Raivo; Valk, Kristjan; Vosa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tonisson, Neeme (2017). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer (vol 7, e39813, 2012). PLOS ONE, 1, ARTN e0170833.10.1371/journal.pone.0170833.
1.1.
2016
Lessard, Samuel; Manning, Alisa K; Low-Kam, Cécile; Auer, Paul L; Giri, Ayush; Graff, Mariaelisa; Schurmann, Claudia; Yaghootkar, Hanieh; Luan, Jian'an; Esko, Tonu; Karaderi, Tugce; Bottinger, Erwin P; Lu, Yingchang; Carlson, Chris; Caulfield, Mark; Dubé, Marie-Pierre; Jackson, Rebecca D; Kooperberg, Charles; McKnight, Barbara; Mongrain, Ian ... Lettre, Guillaume (2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. Human Molecular Genetics, 25 (10), 1−11.10.1093/hmg/ddw055.
1.1.
2016
Ivanov, Maxim; Kals, Mart; Lauschke, Volker; Barragan, Isabel; Ewels, Philip; Käller, Max; Axelsson, Tomas; Lehtiö, Janne; Milani, Lili; Ingelman-Sundberg, Magnus (2016). Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression. Nucleic Acids Research, 44 (14), 6756−6769.doi:10.1093/nar/gkw316.
1.1.
2016
Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van, Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ ... Sullivan, PF . (2016). Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience, 19 (3), 420−433.10.1038/nn.4228.
1.1.
2016
Pettai, Kristi; Milani, Lili; Tammiste, Anu; Võsa, Urmo; Kolde, Raivo; Eller, Triin; Nutt, David; Metspalu, Andres; Maron, Eduard (2016). Whole-genome expression analysis reveals genes associated with treatment response to escitalopram in major depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 26 (9), 1475−1483.10.1016/j.euroneuro.2016.06.007.
1.1.
2016
Limbach, Maia; Saare, Mario; Tserel, Liina; Kisand, Kai; Eglit, Triin; Sauer, Sascha; Axelsson, Tomas; Syvänen, Ann-Christine; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2016). Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. Journal of Autoimmunity, 67, 46−56.10.1016/j.jaut.2015.09.006.
1.1.
2016
Thiéry, Odile; Vasar, Martti; Jairus, Teele; Davison, John; Roux, Christophe; Kivistik, Paula-Ann; Metspalu, Andres; Milani, Lili; Saks, Ülle; Moora, Mari; Zobel, Martin; Öpik, Maarja (2016). Sequence variation in nuclear ribosomal small subunit, internal transcribed spacer and large subunit regions of Rhizophagus irregularis and Gigaspora margarita is high and isolate-dependent. Molecular Ecology, 25 (12), 2816−2832.10.1111/mec.13655.
1.1.
2016
Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement; Fontanillas, Pierre; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M ... McCarthy, Mark I (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41−47.10.1038/nature18642.
1.1.
2016
Okbay, Aysu; Beauchamp, Jonathan P; Fontana, Mark Alan; Lee, James J; Pers, Tune H; Rietveld, Cornelius A; Turley, Patrick; Chen, Guo-Bo; Emilsson, Valur; Meddens, S Fleur W; Oskarsson, Sven; Pickrell, Joseph K; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; Ahluwalia, Tarunveer S; Bacelis, Jonas; Baumbach, Clemens; Bjornsdottir, Gyda ... Benjamin, Daniel J (2016). Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533 (7604), 539−542.10.1038/nature17671.
1.1.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8), 856−866.10.1038/ng.3598.
1.1.
2016
Barban N, Jansen R, de Vlaming R, Vaez A, Mandemakers JJ, Tropf FC, Shen X, Wilson JF, Chasman DI, Nolte IM, Tragante V, van der Laan SW, Perry JR, Kong A; BIOS Consortium, Ahluwalia TS, Albrecht E, Yerges-Armstrong L, Atzmon G, Auro K, Ayers K, Bakshi A, Ben-Avraham D, Berger K, Bergman A, Bertram L, Bielak LF, Bjornsdottir G, Bonder MJ, Broer L, Bui M, Barbieri C, Cavadino A, Chavarro JE, Turman C, Concas MP, Cordell HJ, Davies G, Eibich P, Eriksson N, Esko T, Eriksson J, Falahi F, Felix JF, Fontana MA, Franke L, Gandin I, Gaskins AJ, Gieger C, Gunderson EP, Guo X, Hayward C, He C, Hofer E, Huang H, Joshi PK, Kanoni S, Karlsson R, Kiechl S, Kifley A, Kluttig A, Kraft P, Lagou V, Lecoeur C, Lahti J, Li-Gao R, Lind PA, Liu T, Makalic E, Mamasoula C, Matteson L, Mbarek H, McArdle PF, McMahon G, Meddens SF, Mihailov E, Miller M, Missmer SA, Monnereau C, van der Most PJ, Myhre R, Nalls MA, Nutile T, Kalafati IP, Porcu E, Prokopenko I, Rajan KB, Rich-Edwards J, Rietveld CA, Robino A, Rose LM, Rueedi R, Ryan KA, Saba Y, Schmidt D, Smith JA, Stolk L, Streeten E, Tönjes A, Thorleifsson G, Ulivi S, Wedenoja J, Wellmann J, Willeit P, Yao J, Yengo L, Zhao JH, Zhao W, Zhernakova DV, Amin N, Andrews H, Balkau B, Barzilai N, Bergmann S, Biino G, Bisgaard H, Bønnelykke K, Boomsma DI, Buring JE, Campbell H, Cappellani S, Ciullo M, Cox SR, Cucca F, Toniolo D, Davey-Smith G, Deary IJ, Dedoussis G, Deloukas P, van Duijn CM, de Geus EJ, Eriksson JG, Evans DA, Faul JD, Sala CF, Froguel P, Gasparini P, Girotto G, Grabe HJ, Greiser KH, Groenen PJ, de Haan HG, Haerting J, Harris TB, Heath AC, Heikkilä K, Hofman A, Homuth G, Holliday EG, Hopper J, Hyppönen E, Jacobsson B, Jaddoe VW, Johannesson M, Jugessur A, Kähönen M, Kajantie E, Kardia SL, Keavney B, Kolcic I, Koponen P, Kovacs P, Kronenberg F, Kutalik Z, La Bianca M, Lachance G, Iacono WG, Lai S, Lehtimäki T, Liewald DC; LifeLines Cohort Study, Lindgren CM, Liu Y, Luben R, Lucht M, Luoto R, Magnus P, Magnusson PK, Martin NG, McGue M, McQuillan R, Medland SE, Meisinger C, Mellström D, Metspalu A, Traglia M, Milani L, Mitchell P, Montgomery GW, Mook-Kanamori D, de Mutsert R, Nohr EA, Ohlsson C, Olsen J, Ong KK, Paternoster L, Pattie A, Penninx BW, Perola M, Peyser PA, Pirastu M, Polasek O, Power C, Kaprio J, Raffel LJ, Räikkönen K, Raitakari O, Ridker PM, Ring SM, Roll K, Rudan I, Ruggiero D, Rujescu D, Salomaa V, Schlessinger D, Schmidt H, Schmidt R, Schupf N, Smit J, Sorice R, Spector TD, Starr JM, Stöckl D, Strauch K, Stumvoll M, Swertz MA, Thorsteinsdottir U, Thurik AR, Timpson NJ, Tung JY, Uitterlinden AG, Vaccargiu S, Viikari J, Vitart V, Völzke H, Vollenweider P, Vuckovic D, Waage J, Wagner GG, Wang JJ, Wareham NJ, Weir DR, Willemsen G, Willeit J, Wright AF, Zondervan KT, Stefansson K, Krueger RF, Lee JJ, Benjamin DJ, Cesarini D, Koellinger PD, den Hoed M, Snieder H, Mills MC. (2016). Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nature Genetics, 48 (12), 1462−1472.10.1038/ng.3698.
1.1.
2016
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stančáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D'Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N, Graff M, Grallert H, Grarup N, Gräßler J, Grewal J, Hamsten A, Harder MN, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Havulinna AS, Heliövaara M, Hillege H, Hofman A, Holmen O, Homuth G, Hottenga JJ, Hui J, Husemoen LL, Hysi PG, Isaacs A, Ittermann T, Jalilzadeh S, James AL, Jørgensen T, Jousilahti P, Jula A, Marie Justesen J, Justice AE, Kähönen M, Karaleftheri M, Tee Khaw K, Keinanen-Kiukaanniemi SM, Kinnunen L, Knekt PB, Koistinen HA, Kolcic I, Kooner IK, Koskinen S, Kovacs P, Kyriakou T, Laitinen T, Langenberg C, Lewin AM, Lichtner P, Lindgren CM, Lindström J, Linneberg A, Lorbeer R, Lorentzon M, Luben R, Lyssenko V, Männistö S, Manunta P, Leach IM, McArdle WL, Mcknight B, Mohlke KL, Mihailov E, Milani L, Mills R, Montasser ME, Morris AP, Müller G, Musk AW, Narisu N, Ong KK, Oostra BA, Osmond C, Palotie A, Pankow JS, Paternoster L, Penninx BW, Pichler I, Pilia MG, Polašek O, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rayner NW, Ribel-Madsen R, Rice TK, Richards M, Ridker PM, Rivadeneira F, Ryan KA, Sanna S, Sarzynski MA, Scholtens S, Scott RA, Sebert S, Southam L, Sparsø TH, Steinthorsdottir V, Stirrups K, Stolk RP, Strauch K, Stringham HM, Swertz MA, Swift AJ, Tönjes A, Tsafantakis E, van der Most PJ, Van Vliet-Ostaptchouk JV, Vandenput L, Vartiainen E, Venturini C, Verweij N, Viikari JS, Vitart V, Vohl MC, Vonk JM, Waeber G, Widén E, Willemsen G, Wilsgaard T, Winkler TW, Wright AF, Yerges-Armstrong LM, Hua Zhao J, Carola Zillikens M, Boomsma DI, Bouchard C, Chambers JC, Chasman DI, Cusi D, Gansevoort RT, Gieger C, Hansen T, Hicks AA, Hu F, Hveem K, Jarvelin MR, Kajantie E, Kooner JS, Kuh D, Kuusisto J, Laakso M, Lakka TA, Lehtimäki T, Metspalu A, Njølstad I, Ohlsson C, Oldehinkel AJ, Palmer LJ, Pedersen O, Perola M, Peters A, Psaty BM, Puolijoki H, Rauramaa R, Rudan I, Salomaa V, Schwarz PE, Shudiner AR, Smit JH, Sørensen TI, Spector TD, Stefansson K, Stumvoll M, Tremblay A, Tuomilehto J, Uitterlinden AG, Uusitupa M, Völker U, Vollenweider P, Wareham NJ, Watkins H, Wilson JF, Zeggini E, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, van Duijn CM, Fox C, Groop LC, Heid IM, Hunter DJ, Kaplan RC, McCarthy MI, North KE, O'Connell JR, Schlessinger D, Thorsteinsdottir U, Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJ. (2016). A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications, e13357, 1−11.10.1038/ncomms13357.
1.1.
2016
Guerra, D.; Ghiselli, F.; Milani, L.; Breton, S.; Passamonti, M. (2016). Early replication dynamics of sex-linked mitochondrial DNAs in the doubly uniparental inheritance species Ruditapes philippinarum (Bivalvia Veneridae). Heredity, 116 (3), 314−322.10.1038/hdy.2015.105.
1.1.
2016
Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G; Social Science Genetic Association Consortium, Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences of the United States of America, 113 (47), 13366−13371.10.1073/pnas.1605334113.
1.1.
2016
Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; Davis, Avery; Hammond, Timothy R.; Kamitaki, Nolan; Tooley, Katherine; Presumey, Jessy; Baum, Matthew; Van Doren, Vanessa; Genovese, Giulio; Rose, Samuel A.; Handsaker, Robert E.; Daly, Mark J.; Carroll, Michael C.; Stevens, Beth; McCarroll, Steven A. (2016). Schizophrenia risk from complex variation of complement component 4. Nature, 530 (7589), 177−194.10.1038/nature16549.
5.1.
2016
Tasa, Tonis; Metsvaht, Tuuli; Kalamees, Riste; Milani, Lili; Vilo, Jaak; Lutsar, Irja (2016). Personalised Bayesian Dose Adjustment of Vancomycin in Neonates. Human Heredity, 81 (4), 236−236.
5.1.
2016
Peterson, P.; Tserel, L.; Kolde, R.; Limbach, M.; Tretyakov, K.; Kasela, S.; Kisand, K.; Saare, M.; Vilo, J.; Metspalu, A.; Milani, L. (2016). Age-related profiling of DNA methylation in CD8+T cells reveals changes in immune response and transcriptional regulator genes. European Journal of Immunology, 879−879.
5.1.
2016
Kantojarvi, K.; Liuhanen, J.; Saarenpaa-Heikkila, O.; Satomaa, A. -L; Kylliainen, A.; Polkki, P.; Jaatela, J.; Milani, L.; Himanen, S. -L.; Porkka-Heiskanen, T.; Paavonen, J.; Paunio, T. (2016). Variants in CACNA1C are associated with sleep regulation in infants. European Neuropsychopharmacology, 192−192.WOS:000413843800345.
6.8.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno. (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (10), 1296−1296.10.1038/ng1016-1296c.
6.8.
2016
Nikopensius, T.; Saag, M.; Jagomagi, T.; Annilo, T.; Kals, M.; Kivistik, P. A.; Milani, L.; Metspalu, A. (2016). A missense mutation in DUSP6 is associated with Class III malocclusion (vol 92, pg 893, 2013). Journal Of Dental Research, 8, 955−955.10.1177/0022034516651438.
1.1.
2015
Westra, HJ; Arends, D; Esko, T; Peters, MJ; Schurmann, C; Schramm, K; Kettunen, J; Yaghootkar, H; Fairfax, BP; Andiappan, AK; Li, Y; Fu, J; Karjalainen, J; Platteel, M; Visschedijk, M; Weersma, RK; Kasela, S; Milani, L; Tserel, L; Peterson, P ... Franke, L. (2015). Cell Specific eQTL Analysis without Sorting Cells. PLOS Genetics, 11 (5), e1005223.10.1371/journal.pgen.1005223.
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2015
Bulik-Sullivan, BK.; Loh, PR.; Finucane, HK.; Ripke, S.; Yang, J.; Schizophrenia Working Group of the Psychiatric, Genomics Consortium; Patterson, N.; Daly, MJ.; Price, AL.; Neale, BM. (2015). LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nature Genetics, 47 (3), 291−295.10.1038/ng.3211.
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2015
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Huan, Tianxiao; Esko, Tõnu; Peters, Marjolein J; Pilling, Luke C; Schramm, Katharina; Schurmann, Claudia; Chen, Brian H; Liu, Chunyu; Joehanes, Roby; Johnson, Andrew D; Yao, Chen; Ying, Sai-Xia; Courchesne, Paul; Milani, Lili; Raghavachari, Nalini; Wang, Richard; Liu, Poching; Reinmaa, Eva; Dehghan, Abbas; Hofman, Albert ... Levy, Daniel. (2015). A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension. PLOS Genetics, 11 (3), e1005035.10.1371/journal.pgen.1005035.
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Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Locke, AE; Mägi, R; Strawbridge, RJ; Pers, TH; Fischer, K; Justice, AE; Workalemahu, T; Wu, JM; Buchkovich, ML; Heard-Costa, NL; Roman, TS; Drong, AW; Song, C; Gustafsson, S; Day, FR; Esko, T ... Mohlke, KL. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187−196.10.1038/nature14132.
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Putku, Margus; Kals, Mart; Inno, Rain; Kasela, Silva; Org, Elin; Kožich, Viktor; Milani, Lili; Laan, Maris (2015). CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs. Human Genetics, 134 (3), 291−303.10.1007/s00439-014-1521-6.
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Milani, Lili; Leitsalu, Liis; Metspalu, Andres (2015). An epidemiological perspective of personalized medicine: the Estonian experience. Journal of Internal Medicine, 277 (2), 188−200.10.1111/joim.12320.
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The, Coffee, and, Caffeine, Genetics, Consortium; Cornelis, MC; Byrne, EM; Esko, T; Nalls, MA; Ganna, A; Paynter, N; Monda, KL; Amin, N; Fischer, K; Renstrom, F; Ngwa, JS; Huikari, V; Cavadino, A; Nolte, IM; Teumer, A; Yu, K; Marques-Vidal, P; Rawal, R; Manichaikul, A ... Chasman, DI. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647−656.10.1038/mp.2014.107.
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Yang, J; Bakshi, A; Zhu, Z; Hemani, G; Vinkhuyzen, AAE; Lee, SH (; Robinson, MR; Perry, JRB; Nolte, IM; van Vliet-Ostaptchouk, JV; Snieder, H; Esko, T; Milani, L; Magi, R; Metspalu, A; Hamsten, A; Magnusson, PKE; Pedersen, NL; Ingelsson, E; Soranzo, N ... Visscher, PM. (2015). Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics, 47 (10), 1114−1120.10.1038/ng.3390.
1.1.
2015
Kato, N; Loh, M; Takeuchi, F; Verweij, N; Wang, X; Zhang, W; Kelly, TN; Saleheen, D; Lehne, B; Mateo, Leach, I; Drong, AW; Abbott, J; Wahl, S; Tan, ST; Scott, WR; Campanella, G; Chadeau-Hyam, M; Afzal, U; Ahluwalia, TS; Bonder, MJ ... Chambers, JC. (2015). Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nature Genetics, 47 (11), 1282−1293.10.1038/ng.3405.
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2015
Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F.; Chu, Su; Czajkowski, Jacek; Esko, Tonu; Fall, Tove; Kilpelainen, Tuomas O.; Lu, Yingchang; Magi, Reedik; Mihailov, Evelin; Pers, Tune H.; Rueeger, Sina; Teumer, Alexander; Ehret, Georg B.; Ferreira, Teresa; Heard-Costa, Nancy L.; Karjalainen, Juha ... Loos, Ruth J. F. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLOS Genetics, 11 (10), ARTN e1005378.10.1371/journal.pgen.1005378.
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Locke, AE.; Kahali, B.; Berndt, SI.; Justice, AE.; Pers, TH.; Day, FR.; Powell, C.; Vedantam, S.; Buchkovich, ML.; Yang, J.; Croteau-Chonka, DC.; Esko, T.; Fall, T.; Ferreira, T.; Gustafsson, S.; Kutalik, Z.; Luan, J.; Mägi, R.; Randall, JC.; Winkler, TW. ... Speliotes, EK. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197−206.10.1038/nature14177.
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Peters, Marjolein J.; Joehanes, Roby; Pilling, Luke C.; Schurmann, Claudia; Conneely, Karen N.; Powell, Joseph; Reinmaa, Eva; Sutphin, George L.; Zhernakova, Alexandra; Schramm, Katharina; Wilson, Yana A.; Kobes, Sayuko; Tukiainen, Taru; Ramos, Yolande F.; Goering, Harald H. H.; Fornage, Myriam; Liu, Yongmei; Gharib, Sina A.; Stranger, Barbara E.; De Jager, Philip L. ... Johnson, Andrew D. (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, ARTN 8570.10.1038/ncomms9570.
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Joshi, Peter K.; Esko, Tõnu; Mattsson, Hannele; Eklund, Niina; Gandin, Ilaria; Nutile, Teresa; Jackson, Anne U.; Schurmann, Claudia; Smith, Albert V.; Zhang, Weihua; Okada, Yukinori; Stancakova, Alena; Faul, Jessica D.; Zhao, Wei; Bartz, Traci M.; Concas, Maria Pina; Franceschini, Nora; Enroth, Stefan; Vitart, Veronique; Trompet, Stella ... Wilson, James F. (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523 (7561), 459−476.10.1038/nature14618.
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2014
Benyamin, B; Esko, T; Ried, JS; Radhakrishnan, A; Vermeulen, SH; Traglia, M; Gögele, M; Anderson, D; Broer, L; Podmore, C; Luan, J; Kutalik, Z; Sanna, S; van, der, Meer, P; Tanaka, T; Wang, F; Westra, HJ; Franke, L; Mihailov, E; Milani, L ... Whitfield, JB. (2014). Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications, 5 (4926), 1−7.10.1038/ncomms5926.
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2014
Knappskog, S.; Gansmo, L.B.; Dibirova, K.; Metspalu, A.; Cybulski, C.; Peterlongo, P.; Aaltonen, L.; Vatten, L.; Romundstad, P.; Hveem, K.; Devilee, P.; Evans, G.D.; Lin, D.; Van, Camp, G.; Manolopoulos, V.G.; Osorio, A.; Milani, L.; Ozcelik, T.; Zalloua, P.; Mouzaya, F. ... Lønning, P.E. (2014). Population, distribution, and, ancestry, of, the, cancer, protective, MDM2, SNP285, (rs117039649). Oncotarget, 5 (18), 8224−8234.
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2014
Dumas, O.; Laurent, E.; Bousquet, J.; Metspalu, A.; Milani, L.; Kauffmann, F.; Le Moual, N. (2014). Occupational irritants and asthma: an Estonian cross-sectional study of 34 000 adults. European Respiratory Journal, 44 (3), 647−656.10.1183/09031936.00172213.
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2014
González, JR; Cáceres, A; Esko, T; Cuscó, I; Puig, M; Esnaola, M; Reina, J; Siroux, V; Bouzigon, E; Nadif, R; Reinmaa, E; Milani, L; Bustamante, M; Jarvis, D; Antó, JM; Sunyer, J; Demenais, F; Kogevinas, M; Metspalu, A; Cáceres, M ... Pérez-Jurado, LA. (2014). A Common 16p11.2 Inversion Underlies the Joint Susceptibility to Asthma and Obesity. American Journal of Human Genetics, 94 (3), 361−372.10.1016/j.ajhg.2014.01.015.
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2014
Perry, J.R.B.; Day, F.; Elks, C.E.; Sulem, P.; Thompson, D.J.; Ferreira, T.; He, C.; Chasman, D.I.; Esko, T.; Thorleifsson, G.; Albrecht, E.; Ang, W.Q.; Corre, T.; Cousminer, D.L.; Feenstra, B.; Franceschini, N.; Ganna, A.; Johnson, A.D.; Kjellqvist, S.; Lunetta, K.L. ... Ong, K.K. (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92.10.1038/nature13545.
1.1.
2014
Schizophrenia Working Group of the Psychiatric Genomics Consortium ... Metspalu, A; Milani, L; Nelis, M; Esko, T. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511 (7510), 421−427.10.1038/nature13595.
1.1.
2014
Metsalu, Tauno; Viltrop, Triin; Tiirats, Airi; Rajashekar, Balaji; Reimann, Ene; Kõks, Sulev; Rull, Kristiina; Milani, Lili; Acharya, Ganesh; Basnet, Purusotam; Vilo, Jaak; Mägi, Reedik; Metspalu, Andres; Peters, Maire; Haller-Kikkatalo, Kadri; Salumets, Andres (2014). Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. Epigenetics, 9 (10), 1397−1409.10.4161/15592294.2014.970052.
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Winkler, T.W.; Day, FR.; Croteau-Chonka, DC.; Wood, AR.; Locke, AE.; Magi, R.; Ferreira, T.; Fall, T.; Graff, M.; Justice, AE.; Luan, JA.; Gustafsson, S.; Randall, JC.; Vedantam, S.; Workalemahu, T.; Kilpelainen, TO.; Scherag, A.; Esko, T.; Kutalik, Z.; Heid, IM. ... Loos, RJF (2014). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5), 1192−1212.10.1038/nprot.2014.071.
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Tserel, Liina; Limbach, Maia; Saare, Mario; Kisand, Kai; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2014). CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing. Immunity and Ageing, 11 (1), Article Number: 1 (1-5).
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Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y14; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J ... Frayling, TM. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173−1186.10.1038/ng.3097.
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2014
Knappskog, Stian; Gansmo, Liv B.; Dibirova, Khadizha; Metspalu, Andres; Cybulski, Cezary; Peterlongo, Paolo; Aaltonen, Lauri; Vatten, Lars; Romundstad, Pal; Hveem, Kristian; Devilee, Peter; Evans, Gareth D.; Lin, Dongxin; Van Camp, Guy; Manolopoulos, Vangelis G.; Osorio, Ana; Milani, Lili; Ozcelik, Tayfun; Zalloua, Pierre; Mouzaya, Francis ... Lonning, Per E. (2014). Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649). Oncotarget, 5 (18), 8223−8234.
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2014
Viltrop, T.; Metsalu, T.; Tiirats, A.; Rajashekar, B.; Reimann, E.; Koks, S.; Rull, K.; Milani, L.; Vilo, J.; Maegi, R.; Metspalu, A.; Peters, M.; Haller-Kikkatalo, K.; Salumets, A. (2014). Imprinting landscape of human placenta as discovered by whole transcriptome RNA-sequencing and exome variant data analysis. Human Reproduction, 29, 72−72.
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2013
Ivanov, M; Kals, M; Kacevska, M; Barragan, I; Kasuga, K; Rane, A; Metspalu, A; Milani, L; Ingelman-Sundberg, M. (2013). Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function. Genome Biology, 14 (8), R83.
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2013
Westra, HJ; Peters, MJ; Esko, T; Yaghootkar, H; Schurmann, C; Kettunen, J; Christiansen, MW; Fairfax, BP; Schramm, K; Powell, JE; Zhernakova, A; Zhernakova, DV; Veldink, JH; Van den Berg, LH; Karjalainen, J; Withoff, S; Uitterlinden, AG; Hofman, A; Rivadeneira, F; 't Hoen, PA ... Franke, L. (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45 (10), 1238−U195.10.1038/ng.2756.
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Nikopensius, T; Saag, M; Jagomägi, T; Annilo, T; Kals, M; Kivistik, P.A; Milani, L; Metspalu, A. (2013). A Missense Mutation in DUSP6 is Associated with Class III Malocclusion. Journal of Dental Research, 92 (10), 893−898.10.1177/0022034513502790.
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Rietveld, CA; Medland, SE; Derringer, J; Yang, J; Esko, T; Martin, NW; Westra, HJ; Shakhbazov, K; Abdellaoui, A; Agrawal, A; Albrecht, E; Alizadeh, BZ; Amin, N; Barnard, J; Baumeister, SE; Benke, KS; Bielak, LF; Boatman, JA; Boyle, PA; Davies, G ... Koellinger, PD. (2013). GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science, 340 (6139), 1467−1471.10.1126/science.1235488.
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2013
den Hoed, M; Eijgelsheim, M; Esko, T; Brundel, BJ; Peal, DS; Evans, DM; Nolte, IM; Segrè, AV; Holm, H; Handsaker, RE; Westra, HJ; Johnson, T; Isaacs, A; Yang, J; Lundby, A; Zhao, JH; Kim, YJ; Go, MJ; Almgren, P; Bochud, M ... Loos, RJ. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6), 621.
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Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69.10.1038/ng.2606.
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Ivanov, Mart; Kals, Mart; Kacevska, Marina; Metspalu, Andres; Ingelman-Sundberg, Magnus; Milani, Lili. (2013). In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes. Nucleic Acids Research, 2013/01/15, 1−9.
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Perry, JR; Corre, T; Esko, T; Chasman, DI; Fischer, K; Franceschini, N; He, C; Kutalik, Z; Mangino, M; Rose, LM; Smith, AV; Stolk, L; Sulem, P; Weedon, MN; Zhuang, WV; Arnold, A; Ashworth, A; Bergmann, S; Buring, JE; Burri, A ... Murray, A (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Human Molecular Genetics, 22(7) (1), 1465−1472.10.1093/hmg/dds551.
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Kacevska, Marina; Ivanov, Maxim; Wyss, Annika; Kasela, Silva; Milani, Lili; Rane, Anders; Ingelman-Sundberg, Magnus (2012). DNA methylation dynamics in the hepatic CYP3A4 gene promoter. Biochimie, 94 (11), 2338−2344.10.1016/j.biochi.2012.07.013.
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Lokk, Kaie; Vooder, Tõnu; Kolde, Raivo; Välk, Kristjan; Võsa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltšina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tõnisson, Neeme (2012). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer. PLOS ONE, 7 (6), e39813− .10.1371/journal.pone.0039813.
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Nordlund, J.; Milani, L.; Lundmark, A.; Lönnerholm, G.; Syvänen, AC. (2012). DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission. PLoS ONE, 7 (4), e34513.
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Tserel, L.; Saare, M.; Kisand, K.; Milani, L.; Metspalu, A.; Peterson, P. (2012). Patterns of DNA methylation in the T-cells and monocytes from the elderly and the young. Immunology, 137, 432−433.
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Tõnisson, N.; Lokk, K.; Vooder, T.; Kolde, R.; Välk, K.; Roosipuu, R.; Võsa, U.; Milani, L.; Fischer, K.; Koltšina, M.; Urgard, E.; Annilo, T.; Metspalu, A. (2012). Altered DNA methylation in early-stage non-small-cell lung cancer. European Journal of Human Genetics: European Human Genetics Conference; Nürnberg, Saksamaa; 23.–26. juuni, 2012. Nature Publishing Group, 174−174. (20; Suppl 1).
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Metspalu, A.; Leitsalu, L.; Milani, L.; Esko, T.; Allik, A.; Lilienthal, M.-L.; Haller, T.; Kaasik, A.-T.;Nelis, M.; Hass, M.; Fischer, K.; Krjutškov, K.; Leego, E.; Alavere, H.; Perola, M. (2011). The Estonian biobank - the gateway for the stratified medicine. In: Engelbrecht, J. (Ed.). Research in Estonia. Present and future. (283−301).. Tallinn: Estonian Academy of Sciences.
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Milani, L.; Lundmark, A.; Kiialainen, A.; Nordlund, J.; Flaegstad, T.; Forestier, E.; Heyman, M.; Jonmundsson, G.; Kanerva, J.; Schmiegelow, K.; Söderhäll, S.; Gustafsson, M. G.; Lönnerholm, G.; Syvänen, A. C. (2010). DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood, 115 (6), 1214−1225.10.1182/blood-2009-04-214668.
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Mukonzo, J. K.; Roshammar, D.; Waako, P.; Andersson, M.; Fukasawa, T.; Milani, L.; Svensson, J. O.;Ogwal-Okeng, J.;Gustafsson, L. L.;Aklillu, E. (2009). A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans. British Journal of Clinical Pharmacology, 68, 690−699.
1.1.
2009
Ghotbi R, Gomez A, Milani L, Tybring G, Syvänen A-C, Bertilsson L, Ingelman-Sundberg M, Aklillu E (2009). Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers. The pharmacogenomics journal, 9 (3), 208−217.10.1038/tpj.2009.4.
1.1.
2009
Milani, L.; Lundmark, A.; Nordlund, J.; Kiialainen, A.; Flaegstad, T.; Jonmundsson, G.; Kanerva, J.; Schmiegelow, K.; Gunderson, K.L.; Lönnerholm, G.; Syvänen, A-C. (2009). Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation. Genome Research, 19 (1), 1−11.10.1101/gr.083931.108.
3.1.
2009
Milani, Lili; Syvänen, Ann-Christine. (2009). Genotyping single nucleotide polymorphisms by multiplex minisequencing using tag-arrays. In: DNA Microarrays for Biomedical Research (215−229).. Humana Press. (Methods in Molecular Biology).
1.1.
2008
Schnorrer, F.; Ahlford, A.; Chen, D.; Milani, L.; Syvänen, AC. (2008). Positional cloning by fast-track SNP-mapping in Drosophila melanogaster. Nature Protocols, 3 (11), 1751−1765.10.1038/nprot.2008.175.
1.1.
2008
Kristjansdottir, G.; Sandling, JK.; Bonetti, A.; Roos, IM.; Milani, L.; Wang, C.; Gustafsdottir, SM.; Sigurdsson, S.; Lundmark, A.; Tienari, PJ.; Koivisto, K.; Elovaara, I.; Pirttilä, T.; Reunanen, M.; Peltonen, L.; Saarela, J.; Hillert, J.; Olsson, T.; Landegren, U.; Alcina, A. ... Syvänen, A-C. (2008). Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. Journal of Medical Genetics, 45 (6), 362−369.
1.1.
2008
Sigurdsson, S.; Goring, HH.; Kristjansdottir, G.; Milani, L.; Nordmark, G.; Sandling, JK.; Eloranta, ML.; Feng, D.; Sangster-Guity, N.; Gunnarsson, I.; Svenungsson, E.; Sturfelt, G.; Jonsen, A.; Truedsson, L.; Barnes, BJ.; Alm, G.; Rönnblom, L.; Syvänen, A-C.. (2008). Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Human Molecular Genetics, 17 (6), 872−881.10.1093/hmg/ddm359.
1.1.
2008
Gupta M, Milani L, Hermansson M, Simonsson B, Markevarn B, Syvänen A-C, Barbany G. (2008). Expression of BCR-ABL1 oncogene relative to ABL1 gene changes overtime in chronic myeloid leukemia. Biochemical and Biophysical Research Communications, 366 (3), 848−851.10.1016/j.bbrc.2007.12.029.
1.1.
2007
Dideberg, V; Kristjansdottir, G; Milani, L; Libioulle, C; Sigurdsson, S; Louis, E; Wiman, AC; Vermeire, S; Rutgeerts, P; Belaiche, J; Franchimont, D; Van Gossum, A; Bours, V; Syvänen, A-C. (2007). An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Human Molecular Genetics, 16 (24), 3008−3016.10.1093/hmg/ddm259.
1.1.
2007
Milani L, Gupta M, Andersen M, Dhar S, Fryknäs M, Isaksson A, Larsson R, Syvänen A-C. (2007). Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells. Nucleic Acids Research, 35, e34−e34.10.1093/nar/gkl1152.
1.1.
2006
Milani L, Fredriksson M, Syvänen A-C. (2006). Detection of alternatively spliced transcripts in leukemia cell lines by minisequencing on microarrays. Clinical Chemistry, 52, 202−211.10.1373/clinchem.2005.062042.

Tööstusomand

4.09.2020

Lili Azin Milani

https://www.etis.ee/CV/Lili Azin_Milani/eng
27.11.1981
737 4039
lili.milani@ut.ee
C-8759-2011
Language Skills: Swedish (native), English (fluent), Estonian (fluent), Persian (fluent), French (good), Russian (moderate).

Career

Institutions and positions
2018–...   
University of Tartu, Estonian Genome Center, Research Professor (1,00)
10.09.2012–30.11.2012   
University of Tartu, Estonian Genome Center , Acting Director
2011–31.03.2017   
University of Tartu, Estonian Genome Center, Head of Sequencing and Genotyping Core Facility (0,20)
2010–2012   
University of Tartu, Estonian Genome Center, Post-Doc (1,00)
01.01.2009–31.12.2010   
Uppsala University, Maternity leave (0.80)
01.01.2009–31.12.2010   
Uppsala University, Researcher (0.20)
01.01.2004–31.12.2009   
Uppsala University, PhD student
01.01.2004–31.12.2004   
Research assistant at WCN SNP genotyping unit, Uppsala University
2001–2003   
University of Tartu, Faculty of Medicine, Department of Pathological Anatomy and Forensic Medicine, Chair of Pathological Anatomy, Research assistant (0,50)
 
 
Education
2004–2009   
Uppsala University, Department of Medical Sciences, Molecular medicine; PhD
2000–2004   
Tartu University, Institute of Molecular and Cell Biology; BSc
1994–2000   
Tallinn English College; secondary school
 
 
R&D related managerial and administrative work
2019−...   
Member of the Protection, Promotion and Situation Monitoring Council for Human Rights
2018−...   
Frontiers in Genetics Associate Editor
2016−...   
Member of the Evaluation Board for Personal Research Support of Estonian Research Council
2005−2007   
Course instructor at WCN practical course “Applied bioinformatics and methodologies in SNP genotyping”, Uppsala University
2004−2006   
Course instructor and organizer at EU/EMBO practical course “Advanced techniques in molecular medicine”, Uppsala University

Qualifications

Academic degrees
Lili Azin Milani, Doctor's Degree, 2009, (sup) Ann-Christine Syvänen, Gene Expression in Cancer Cells: Detection of Splice Variants, Allele-specific Expression and DNA Methylation, Uppsala University.
 
 
Honours & awards
2019, Lili Azin Milani, National Science Award in chemistry and molecular biology for the series of works "Basic research on genetics and genomics for the implementation of personal medicine in Estonia" (Esko, Mägi, Fischer, Milani)
2019, Lili Azin Milani, University of Tartu, badge of distinction
2015, Lili Azin Milani, Young Scientist Award of the Cultural Foundation of the President
2012, Lili Azin Milani, Estonian Science Foundation grant (4 years)
2011, Lili Azin Milani, MOBILITAS Postdoctoral Research grant (3 years)
2008, Lili Azin Milani, Anna Lundins scholarship for outstanding graduate students
2008, Lili Azin Milani, Keystone Symposia scholarship: Cancer Genomics and Epigenomics meeting
2008, Lili Azin Milani, Hedströms scholarship for outstanding senior graduate students
2007, Lili Azin Milani, Anna Lundins scholarship for outstanding graduate students
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.3. Genetics
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.3. Genetics; SPECIFICATION: epigenetics, gene expression, molecular medicine
ETIS CLASSIFICATION: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; CERCS CLASSIFICATION: B220 Genetics, cytogenetics
 
 
Additional information
WCN course “Applied bioinformatics and methodologies in SNP genotyping”, Uppsala and Stockholm, Sweden 13-19 November, 2004
J.D. Terwilliger course: “Study design issues for gene mapping in complex traits”, Tartu, Estonia 24-26 May, 2004
CSHL course “Eukaryotic gene expression”, Cold Spring Harbor Laboratory, USA 25 June - 15 August, 2005

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2020
Andlauer, Till F. M.; Guzman-Parra, Jose; Streit, Fabian; Strohmaier, Jana; González, Maria José; Gil Flores, Susana; Cabaleiro Fabeiro, Francisco J.; del Río Noriega, Francisco; Perez, Fermin Perez; Haro González, Jesus; Orozco Diaz, Guillermo; de Diego-Otero, Yolanda; Moreno-Küstner, Berta; Auburger, Georg; Degenhardt, Franziska; Heilmann-Heimbach, Stefanie; Herms, Stefan; Hoffmann, Per; Frank, Josef; Foo, Jerome C. ... Rietschel, Marcella (2020). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, online.10.1038/s41380-019-0558-2 [forthcoming].
1.1.
2020
Coleman, Jonathan R. I.; Peyrot, Wouter J.; Purves, Kirstin L.; Davis, Katrina A. S.; Rayner, Christopher; Choi, Shing Wan; Hubel, Christopher; Gaspar, Helena A.; Kan, Carol; Van der Auwera, Sandra; Adams, Mark James; Lyall, Donald M.; Choi, Karmel W.; Dunn, Erin C.; Vassos, Evangelos; Danese, Andrea; Maughan, Barbara; Grabe, Hans J.; Lewis, Cathryn M.; O'Reilly, Paul F. ... Sullivan, Patrick F. (2020). Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank. Molecular Psychiatry.10.1038/s41380-019-0546-6.
1.1.
2020
Glanville, Kylie P.; Coleman, Jonathan R., I; Hanscombe, Ken B.; Euesden, Jack; Choi, Shing Wan; Purves, Kirstin L.; Breen, Gerome; Air, Tracy M.; Andlauer, Till F. M.; Baune, Bernhard T.; Binder, Elisabeth B.; Blackwood, Douglas H. R.; Boomsma, Dorret, I; Buttenschon, Henriette N.; Colodro-Conde, Lucia; Dannlowski, Udo; Direk, Nese; Dunn, Erin C.; Forstner, Andreas J.; de Geus, Eco J. C. ... Borglum, Anders D. (2020). Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression. Biological Psychiatry, 87 (5), 419−430.10.1016/j.biopsych.2019.06.031.
1.1.
2020
Saare, Mario; Tserel, Liina; Haljasmägi, Liis; Taalberg, Egon; Peet, Nadežda; Eimre, Margus; Vetik, Rait; Kingo, Külli; Saks, Kai; Tamm, Riin; Milani, Lili; Kisand, Kai; Peterson, Pärt (2020). Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism. Aging Cell, ARTN e13127.10.1111/acel.13127.
1.1.
2020
Whiffin, Nicola; Armean, Irina M; Kleinman, Aaron; Marshall, Jamie L; Minikel, Eric V; Goodrich, Julia K; Quaife, Nicholas M; Cole, Joanne B; Wang, Qingbo; Karczewski, Konrad J; Cummings, Beryl B; Francioli, Laurent; Laricchia, Kristen; Guan, Anna; Alipanahi, Babak; Morrison, Peter; Baptista, Marco A S; Merchant, Kalpana M; ,; , ... MacArthur, Daniel G (2020). The effect of LRRK2 loss-of-function variants in humans. Nature Medicine, 26 (6), 869−877.10.1038/s41591-020-0893-5.
1.1.
2020
Huang, Y.; Ollikainen, M.; Muniandy, M.; Zhang, T.; van Dongen, J.; Hao, G.; van der Most, P.J.; Pan, Y.; Pervjakova, N.; Sun, Y.V.; Hui, Q.; Lahti, J.; Fraszczyk, E.; Lu, X.; Sun, D.; Richard, M.A.; Willemsen, G.; Heikkila, K.; Mateo Leach, I.; Mononen, N. ... Wang, X. (2020). Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure. Scientific Reports, 76 (1), 195−205.10.1161/HYPERTENSIONAHA.120.14973.
1.1.
2020
Sulkava, Sonja; Taka, Antti-Mathias; Kantojärvi, Katri; Pölkki, Pirjo; Morales-Muñoz, Isabel; Milani, Lili; Porkka-Heiskanen, Tarja; Saarenpää-Heikkilä, Outi; Kylliäinen, Anneli; Juulia Paavonen, E; Paunio, Tiina (2020). Variation near MTNR1A associates with early development and interacts with seasons. Journal of Sleep Research, e12925−e12925.10.1111/jsr.12925 [forthcoming].
1.1.
2020
Zhou, Yitian; Krebs, Kristi; Milani, Lili; Lauschke, Volker M (2020). Global frequencies of clinically important HLA alleles and their implications for the cost-effectiveness of preemptive pharmacogenetic testing. Clinical pharmacology and therapeutics.10.1002/cpt.1944 [forthcoming].
1.1.
2020
de Las Fuentes, Lisa; Sung, Yun Ju; Noordam, Raymond; Winkler, Thomas; Feitosa, Mary F; Schwander, Karen; Bentley, Amy R; Brown, Michael R; Guo, Xiuqing; Manning, Alisa; Chasman, Daniel I; Aschard, Hugues; Bartz, Traci M; Bielak, Lawrence F; Campbell, Archie; Cheng, Ching-Yu; Dorajoo, Rajkumar; Hartwig, Fernando P; Horimoto, A R V R; Li, Changwei ... Fornage, Myriam (2020). Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry.10.1038/s41380-020-0719-3 [forthcoming].
1.1.
2020
Shen, X.; Howard, D.M.; Adams, M.J.; Hill, W.D.; Clarke, T.K.; McIntosh, A.M.; Deary, I.J.; Wray, N.R.; Ripke, S.; Mattheisen, M.; Trzaskowski, M.; Byrne, E.M.; Abdellaoui, A.; Agerbo, E.; Air, T.M.; Andlauer, T.F.M.; Bacanu, S.A.; Bækvad-Hansen, M.; Beekman, A.T.F.; Bigdeli, T.B. ... Owen, M.J. (2020). A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. Nature Communications, 11 (1).10.1038/s41467-020-16022-0.
1.1.
2020
Bovijn, Jonas; Krebs, Kristi; Chen, Chia-Yen; Boxall, Ruth; Censin, Jenny C; Ferreira, Teresa; Pulit, Sara L; Glastonbury, Craig A; Laber, Samantha; Millwood, Iona Y; Lin, Kuang; Li, Liming; Chen, Zhengming; Milani, Lili; Smith, George Davey; Walters, Robin G; Mägi, Reedik; Neale, Benjamin M; Lindgren, Cecilia M; Holmes, Michael V (2020). Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics. Science Translational Medicine, 12 (549).10.1126/scitranslmed.aay6570.
1.1.
2020
Huang, Yisong; Ollikainen, Miina; Muniandy, Maheswary; Zhang, Tao; van Dongen, Jenny; Hao, Guang; van Der Most, Peter J.; Pan, Yue; Pervjakova, Natalia; Sun, Yan, V; Hui, Qin; Lahti, Jari; Fraszczyk, Eliza; Lu, Xueling; Sun, Dianjianyi; Richard, Melissa A.; Willemsen, Gonneke; Heikkila, Kauko; Leach, Irene Mateo; Mononen, Nina ... Wang, Xiaoling (2020). Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure. Hypertension, 76 (1), 195−205.10.1161/HYPERTENSIONAHA.120.14973.
1.1.
2020
Pankratov, Vasili; Montinaro, Francesco; Kushniarevich, Alena; Hudjashov, Georgi; Jay, Flora; Saag, Lauri; Flores, Rodrigo; Marnetto, Davide; Seppel, Marten; Kals, Mart; Vosa, Urmo; Taccioli, Cristian; Mols, Mart; Milani, Lili; Aasa, Anto; Lawson, Daniel John; Esko, Tonu; Magi, Reedik; Pagani, Luca; Metspalu, Andres ... Metspalu, Mait (2020). Differences in local population history at the finest level: the case of the Estonian population. European Journal of Human Genetics.10.1038/s41431-020-0699-4 [forthcoming].
3.1.
2020
MORRISON M; TEARE, H; Bertier, G; BUCHANAN, J; Bylstra, Y; Gaff, C; Jackson, L; Kato, K; Kaufmann, E; Kelly, S; Lazaro-Munoz, G; Leitsalu, L; Milani, L; Schaefer, O; Schickhardt, C; Shabani, M; Tutty, E; Winkler, E; WORDSWORTH, S. (2020). Implications of secondary findings for clinical contexts. In: Secondary Findings in Genomic Research (155−201). Academic Press.
3.1.
2020
Morrison, Michael; Teare, Harriet; Bertier, Gabrielle; Buchanan, James; Bylstra, Yasmin; Gaff, Clara; Jackson, Leigh; Kato, Kazuto; Kaufmann, Elke; Kelly, Susan; Lazaro-Munoz, Gabriel; Leitsalu, Liis; Milani, Lili; Schaefer, G. Owen; Schickhardt, Christoph; Shabani, Mahsa; Tutty, Erin; Winkler, Eva C.; Wordsworth, Sarah (2020). Implications of secondary findings for clinical contexts. In: Langanke, M.; Erdmann, P.; Brothers, KB. (Ed.). SECONDARY FINDINGS IN GENOMIC RESEARCH (155−201). LONDON: ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD. (Translational and Applied Genomics).10.1016/B978-0-12-816549-2.00008-4.
1.1.
2019
Reisberg, Sulev; Krebs, Kristi; Lepamets, Maarja; Kals, Mart; Mägi, Reedik; Metsalu, Kristjan; Lauschke, Volker M.; Vilo, Jaak; Milani, Lili; (2019). Translating genotype data of 44,000 biobank participants into clinical pharmacogenetic recommendations: challenges and solutions. Genetics in medicine.10.1038/s41436-018-0337-5.
1.1.
2019
Tasa, T,; Krebs, K.; Kals, M.; Mägi, R.; Lauschke, V.M.; Haller, T.; Puurand, T.; Remm, M.; Esko, T.; Metspalu, A.; Vilo, J.; Milani, L. (2019). Genetic variation in the Estonian population: pharmacogenomics study of adverse drug effects using electronic health records. European Journal of Human Genetics, 442−454.10.1038/s41431-018-0300-6.
1.1.
2019
Virtanen, V.B.; Salo, P.P.; Cao, J.; Löf-Granström, A.; Milani, L.; Metspalu, A.; Rintala, R.J.; Saarenpää-Heikkilä, O.; Paunio, T.; Wester, T.; Nordenskjöld, A.; Perola, M.; Pakarinen, M.P. (2019). Noncoding RET variants explain the strong association with Hirschsprung disease in patients without rare coding sequence variant. European Journal of Medical Genetics, 62 (4), 229−234.10.1016/j.ejmg.2018.07.019.
1.1.
2019
Kaleviste, Epp; Saare, Mario; Leahy, Timothy Ronan; Bondet, Vincent; Duffy, Darragh; Mogensen, Trine; Jørgensen, Sofie E; Nurm, Helke; Ip, Winnie; Davies, E Graham; Sauer, Sascha; Syvänen, Ann-Christine; Milani, Lili; Peterson, Pärt; Kisand, Kai (2019). Interferon signature in patients with STAT1 gain-of-function mutation is epigenetically determined. European Journal of Immunology.10.1002/eji.201847955.
1.1.
2019
de Vries, Paul S.; Brown, Michael R.; Bentley, Amy R.; Sung, Yun J.; Winkler, Thomas W.; Ntalla, Ioanna; Schwander, Karen; Kraja, Aldi T.; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E.; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Richard, Melissa A.; Noordam, Raymond; Aschard, Hugues ... Morrison, Alanna C. (2019). Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology, 188 (6), 1033−1054.10.1093/aje/kwz005.
1.1.
2019
Timmers, Paul Rhj; Mounier, Ninon; Lall, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew D; Clark, David W; ,; Agbessi, M; Ahsan, H; Alves, I; Andiappan, A; Awadalla, P; Battle, A; Bonder, M J; Boomsma, D; Christiansen, M; Claringbould, A; Deelen, P ... Joshi, Peter K (2019). Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife, 8, e39856.10.7554/eLife.39856.
1.1.
2019
Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F ... Cupples, L Adrienne (2019). Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics, 51 (4), 636−648.10.1038/s41588-019-0378-y.
1.1.
2019
Lahtinen, Alexandra; Puttonen, Sampsa; Vanttola, Päivi; Viitasalo, Katriina; Sulkava, Sonja; Pervjakova, Natalia; Joensuu, Anni; Salo, Perttu; Toivola, Auli; Härmä, Mikko; Milani, Lili; Perola, Markus; Paunio, Tiina (2019). A distinctive DNA methylation pattern in insufficient sleep. Scientific Reports, 9, ARTN 1193.10.1038/s41598-018-38009-0.
1.1.
2019
Harold, Denise; Connolly, Siobhan; Riley, Brien P.; Kendler, Kenneth S.; McCarthy, Shane E.; McCombie, William R.; Richards, Alex; Owen, Michael J.; O'Donovan, Michael C.; Walters, James; Donnelly, Peter; Bates, Lesley; Barroso, Ines; Blackwell, Jenefer M.; Bramon, Elvira; Brown, Matthew A.; Casas, Juan P.; Corvin, Aiden; Deloukas, Panos; Duncanson, Audrey ... Morris, Derek W. (2019). Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophrenia. American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 180 (3), 223−231.10.1002/ajmg.b.32716.
1.1.
2019
Stahl, Eli A; Breen, Gerome; Forstner, Andreas J; McQuillin, Andrew; Ripke, Stephan; Trubetskoy, Vassily; Mattheisen, Manuel; Wang, Yunpeng; Coleman, Jonathan R I; Gaspar, Héléna A; de Leeuw, Christiaan A; Steinberg, Stacy; Pavlides, Jennifer M Whitehead; Trzaskowski, Maciej; Byrne, Enda M; Pers, Tune H; Holmans, Peter A; Richards, Alexander L; Abbott, Liam; Agerbo, Esben ... , (2019). Genome-wide association study identifies 30 loci associated with bipolar disorder. Nature Genetics, 51 (5), 793−803.10.1038/s41588-019-0397-8.
1.1.
2019
Grove, Jakob; Ripke, Stephan; Als, Thomas D.; Mattheisen, Manuel; Walters, Raymond K.; Won, Hyejung; Pallesen, Jonatan; Agerbo, Esben; Andreassen, Ole A.; Anney, Richard; Awashti, Swapnil; Belliveau, Rich; Bettella, Francesco; Buxbaum, Joseph D.; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Cerrato, Felecia; Chambert, Kimberly; Christensen, Jane H.; Churchhouse, Claire ... Wilson, Catherine H. (2019). Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics, 51 (3), 431−447.10.1038/s41588-019-0344-8.
1.1.
2019
Foo, Jerome C.; Streit, Fabian; Frank, Josef; Witt, Stephanie H.; Treutlein, Jens; Baune, Bernhard T.; Moebus, Susanne; Joeckel, Karl-Heinz; Forstner, Andreas J.; Noethen, Markus M.; Rietschel, Marcella; Sartorius, Alexander; Kranaster, Laura; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J. ... Sullivan, Patrick F. (2019). Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy. American Journal of Medical Genetics Part B-neuropsychiatric Genetics, 180 (1), 35−45.10.1002/ajmg.b.32700.
1.1.
2019
Arnau-Soler, Aleix; Macdonald-Dunlop, Erin; Adams, Mark J.; Clarke, Toni-Kim; MacIntyre, Donald J.; Milburn, Keith; Navrady, Lauren; Hayward, Caroline; McIntosh, Andrew M.; Thomson, Pippa A.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Agerbo, Esben; Air, Tracy M.; Andlauer, Till F. M.; Bacanu, Silviu-Alin ... Sullivan, Patrick F. (2019). Genome-wide by environment interaction studies of depressive symptoms and psychosocial stress in UK Biobank and Generation Scotland. Translational Psychiatry, 9, ARTN 14.10.1038/s41398-018-0360-y.
1.1.
2019
Linner, Richard Karlsson; Biroli, Pietro; Kong, Edward; Meddens, Fleur W.; Wedow, Robbee; Fontana, Mark Alan; Lebreton, Mael; Tino, Stephen P.; Abdellaoui, Abdel; Hammerschlag, Anke R.; Nivard, Michel G.; Okbay, Aysu; Rietveld, Cornelius A.; Timshel, Pascal N.; Trzaskowski, Maciej; de Vlaming, Ronald; Zund, Christian L.; Bao, Yanchun; Buzdugan, Laura; Caplin, Ann H. ... Beauchamp, Jonathan P. (2019). Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences. Nature Genetics, 51 (2), 245−261.10.1038/s41588-018-0309-3.
1.1.
2019
Huckins, Laura M.; Dobbyn, Amanda; Ruderfer, Douglas M.; Hoffman, Gabriel; Wang, Weiqing; Pardinas, Antonio F.; Rajagopal, Veera M.; Als, Thomas D.; Nguyen, Hoang T.; Girdhar, Kiran; Boocock, James; Roussos, Panos; Fromer, Menachem; Kramer, Robin; Domenici, Enrico; Gamazon, Eric R.; Purcell, Shaun; Demontis, Ditte; Borglum, Anders D.; Walters, James T. R. ... Sullivan, Patrick F. (2019). Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nature Genetics, 51 (4), 659−677.10.1038/s41588-019-0364-4.
1.1.
2019
Choi, Karmel W.; Chen, Chia-Yen; Stein, Murray B.; Klimentidis, Yann C.; Wang, Min-Jung; Koenen, Karestan C.; Smoller, Jordan W.; Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, TracyM.; Andlauer, Till F. M.; Bacanu, Silviu-Alin; Baekvad-Hansen, Marie; Beekman, Aartjan T. F. ... Sullivan, Patrick F. (2019). Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults A 2-Sample Mendelian Randomization Study. JAMA Psychiatry, 76 (4), 399−408.10.1001/jamapsychiatry.2018.4175.
1.1.
2019
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Musliner, Katherine L.; Mortensen, Preben B.; McGrath, John J.; Suppli, Nis P.; Hougaard, David M.; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Andreassen, Ole; Pedersen, Carsten B.; Pedersen, Marianne G.; Mors, Ole; Nordentoft, Merete; Borglum, Anders D.; Werge, Thomas; Agerbo, Esben; Stahl, Eli A.; Breen, Gerome; Forstner, Andreas J.; McQuillin, Andrew; Ripke, Stephan ... Sklar, Pamela (2019). Association of Polygenic Liabilities for Major Depression, Bipolar Disorder, and Schizophrenia With Risk for Depression in the Danish Population. JAMA Psychiatry, 76 (5), 516−525.10.1001/jamapsychiatry.2018.4166.
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Sung, Yun Ju; de Las Fuentes, Lisa; Winkler, Thomas W.; Chasman, Daniel, I; Bentley, Amy R.; Kraja, Aldi T.; Ntalla, Ioanna; Warren, Helen R.; Guo, Xiuqing; Schwander, Karen; Manning, Alisa K.; Brown, Michael R.; Aschard, Hugues; Feitosa, Mary F.; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan ... Morrison, Alanna C. (2019). A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Human Molecular Genetics, 28 (15), 2615−2633.10.1093/hmg/ddz070.
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Krebs, Kristi; Milani, Lili (2019). Translating pharmacogenomics into clinical decisions: do not let the perfect be the enemy of the good. Human Genomics, 13 (1), 39−39.10.1186/s40246-019-0229-z.
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Clark, David W.; Okada, Yukinori; Moore, Kristjan H. S.; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L. K.; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M. ... Wilson, James F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, ARTN 4957.10.1038/s41467-019-12283-6.
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Barbu, Miruna C.; Zeng, Yanni; Shen, Xueyi; Cox, Simon R.; Clarke, Toni-Kim; Gibson, Jude; Adams, Mark J.; Johnstone, Mandy; Haley, Chris S.; Lawrie, Stephen M.; Deary, Ian J.; McIntosh, Andrew M.; Whalley, Heather C.; Agee, Michelle; Alipanahi, Babak; Auton, Adam; Bell, RobertK; Bryc, Katarzyna; Elson, Sarah L.; Fontanillas, Pierre ... Sullivan, Patrick F. (2019). Association of Whole-Genome and NETRIN1 Signaling Pathway-Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank. Biological Psychiatry-cognitive Neuroscience and Neuroimaging, 4 (1), 91−100.10.1016/j.bpsc.2018.07.006.
6.6.
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Milani, Lili (2019). MIS SIND NÄRVI AJAB | Arstid ei tea midagi! Perefoorumid on nõmedad? Vale puha. Delfi - Eesti Päevaleht.
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Sung, Yun J.; Winkler, Thomas W.; de las Fuentes, Lisa; Bentley, Amy R.; Brown, Michael R.; Kraja, Aldi T.; Schwander, Karen; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K.; Li, Changwei; Feitosa, Mary F.; Kilpelainen, Tuomas O.; Richard, Melissa A. ... Chasman, Daniel I. (2018). A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics, 102 (3), 375−400.10.1016/j.ajhg.2018.01.015.
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Lee, James J; Wedow, Robbee; Okbay, Aysu; Kong, Edward; Maghzian, Omeed; Zacher, Meghan; Nguyen-Viet, Tuan Anh; Bowers, Peter; Sidorenko, Julia; Karlsson Linnér, Richard; Fontana, Mark Alan; Kundu, Tushar; Lee, Chanwook; Li, Hui; Li, Ruoxi; Royer, Rebecca; Timshel, Pascal N; Walters, Raymond K; Willoughby, Emily A; Yengo, Loïc ... Cesarini, David (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. Nature Genetics, 50 (8), 1112−1121.10.1038/s41588-018-0147-3.
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Zhou, Yitian; Mägi, Reedik; Milani, Lili; Lauschke, Volker M (2018). Global genetic diversity of human apolipoproteins and effects on cardiovascular disease risk. Jornal Lipid Research, 59 (10), 1987−2000.10.1194/jlr.P086710.
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Feitosa, Mary F; Kraja, Aldi T; Chasman, Daniel I; Sung, Yun J; Winkler, Thomas W; Ntalla, Ioanna; Guo, Xiuqing; Franceschini, Nora; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Marten, Jonathan; Musani, Solomon K; Li, Changwei; Bentley, Amy R; Brown, Michael R; Schwander, Karen; Richard, Melissa A; Noordam, Raymond; Aschard, Hugues ... Levy, Daniel (2018). Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLOS ONE, 13 (6), e0198166−e0198166.10.1371/journal.pone.0198166.
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Lauschke, Volker M.; Milani, Lili; Ingelman-Sundberg, Magnus (2018). Pharmacogenomic Biomarkers for Improved Drug Therapy- Recent Progress and Future Developments. Aaps Journal, 20 (1), UNSP 4.10.1208/s12248-017-0161-x.
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Wray, Naomi R.; Ripke, Stephan; Mattheisen, Manuel; Trzaskowski, Maciej; Byrne, Enda M.; Abdellaoui, Abdel; Adams, Mark J.; Agerbo, Esben; Air, Tracy M.; Andlauer, Till M. F.; Bacanu, Silviu-Alin; Baekvad-Hansen, Marie; Beekman, Aartjan F. T.; Bigdeli, Tim B.; Binder, Elisabeth B.; Blackwood, Douglas R. H.; Bryois, Julien; Buttenschon, Henriette N.; Bybjerg-Grauholm, Jonas; Cai, Na ... Sullivan, Patrick F. (2018). Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nature Genetics, 50 (5), 668−684.10.1038/s41588-018-0090-3.
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Wahl, Annika; Kasela, Silva; Carnero-Montoro, Elena; van Iterson, Maarten; Stambuk, Jerko; Sharma, Sapna; van den Akker, Erik; Klaric, Lucija; Benedetti, Elisa; Razdorov, Genadij; Trbojevic-Akmacic, Irena; Vuckovic, Frano; Ugrina, Ivo; Beekman, Marian; Deelen, Joris; van Heemst, Diana; Heijmans, Bastiaan T.; Wuhrer, Manfred; Plomp, Rosina; Keser, Toma ... Gieger, Christian (2018). IgG glycosylation and DNA methylation are interconnected with smoking. Biochimica et Biophysica Acta - General Subjects, 1862 (3), 637−648.10.1016/j.bbagen.2017.10.012.
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Lu, Y.; Pouget, J. G.; Andreassen, O. A.; Djurovic, S.; Esko, T.; Hultman, C. M.; Metspalu, A.; Milani, L.; Werge, T.; Sullivan, P. F. (2018). Genetic risk scores and family history as predictors of schizophrenia in Nordic registers. Psychological Medicine, 48 (7), 1201−1208.10.1017/S0033291717002665.
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Ruderfer, Douglas M.; Ripke, Stephan; McQuillin, Andrew; Boocock, James; Stahl, Eli A.; Pavlides, Jennifer M. Whitehead; Mullins, Niamh; Charney, Alexander W.; Ori, Anil P. S.; Loohuis, Loes M. Olde; Domenici, Enrico; Di Florio, Arianna; Papiol, Sergi; Kalman, Janos L.; Trubetskoy, Vassily; Adolfsson, Rolf; Agartz, Ingrid; Agerbo, Esben; Akil, Huda; Albani, Diego ... Kendler, Kenneth S. (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. Cell, 173 (7), ARTN 1715.e16−1732.10.1016/j.cell.2018.05.046.
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6.3.
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2017
Wahl, Simone; Drong, Alexander; Lehne, Benjamin; Loh, Marie; Scott, William R; Kunze, Sonja; Tsai, Pei-Chien; Ried, Janina S; Zhang, Weihua; Yang, Youwen; Tan, Sili; Fiorito, Giovanni; Franke, Lude; Guarrera, Simonetta; Kasela, Silva; Kriebel, Jennifer; Richmond, Rebecca C; Adamo, Marco; Afzal, Uzma; Ala-Korpela, Mika ... Chambers, John C (2017). Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541 (7635), 81−86.10.1038/nature20784.
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Guha M, Saare M, Maslovskaja J, Kisand K, Liiv I, Haljasorg U, Tasa T, Metspalu A, Milani L, Peterson P. (2017). DNA breaks and chromatin structural changes enhance the transcription of Autoimmune Regulator target genes. Journal of Biological Chemistry, 292 (16), 6542−6554.10.1074/jbc.M116.764704.
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Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences of the United States of America, 114 (3), E327−E336.10.1073/pnas.1619052114.
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R Tamm, R Mägi, R Tremmel, S Winter, E Mihailov, A Smid, A Möricke, K Klein, M Schrappe, M Stanulla, R Houlston, R Weinshilboum, Irena Mlinarič Raščan, A Metspalu, L Milani, M Schwab, E Schaeffeler. (2017). Polymorphic Variation in TPMT Is the Principal Determinant of TPMT Phenotype: A Meta-Analysis of Three Genome-Wide Association Studies. Clinical pharmacology and therapeutics, 101 (5), 684−695.10.1002/cpt.540.
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Mihailov, E.; Nikopensius, T.; Reigo, A.; Nikkolo, C.; Kals, M.; Aruaas, K.; Milani, L.; Seepter, H.; Metspalu, A. (2017). Whole-exome sequencing identifies a potential TTN mutation in a multiplex family with inguinal hernia. Hernia, 21 (1), 95−100.10.1007/s10029-016-1491-9.
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Marshall, Christian R.; Marshall, Christian R.; Howrigan, Daniel P.; Merico, Daniele; Thiruvahindrapuram, Bhooma; Wu, Wenting; Greer, Douglas S.; Antaki, Danny; Shetty, Aniket; Holmans, Peter A.; Pinto, Dalila; Gujral, Madhusudan; Brandler, William M.; Malhotra, Dheeraj; Wang, Zhouzhi; Fajarado, Karin V. Fuentes; Maile, Michelle S.; Ripke, Stephan; Agartz, Ingrid; Albus, Margot ... Sebat, Jonathan (2017). Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects. Nature Genetics, 1, 27−35.10.1038/ng.3725.
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Kantojärvi, Katri; Liuhanen, Johanna; Saarenpää-Heikkilä, Outi; Satomaa, Anna-Liisa; Kylliäinen, Anneli; Pölkki, Pirjo; Jaatela, Julia; Toivola, Auli; Milani, Lili; Himanen, Sari-Leena; Porkka-Heiskanen, Tarja; Paavonen, Juulia; Paunio, Tiina (2017). Variants in calcium voltage-gated channel subunit Alpha1 C-gene (CACNA1C) are associated with sleep latency in infants. PLOS ONE, 12 (8), e0180652−e0180652.10.1371/journal.pone.0180652.
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2017
Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark D.W., Nutile T., Barnes C.L.K., Timmers P.R.H.J., Shen X., Gandin I., McDaid A.F., Hansen T.F., Gordon S.D., Giulianini F., Boutin T.S., Abdellaoui A., Zhao W., Medina-Gomez C., Bartz T.M., Trompet S., Lange L.A., Raffield L., van der Spek A.,/.../,Bertram L., Pendleton N., Kardia S.L.R., Ciullo M., Becker D.M., Wong A., Psaty B.M., van Duijn C.M., Wilson J.G., Jukema J.W., Kiemeney L., Uitterlinden A.G, Franceschini N., North K.E., Weir D.R., Metspalu A., Boomsma D.I., Hayward C., Chasman D., Martin N.G., Sattar N., Campbell H., Esko T., Kutalik Z., Wilson J.F. (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, 910.10.1038/s41467-017-00934-5.
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6.3.
2017
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Teadlaste koostöö ettevõtetega – kellele seda vaja on? Sirp, 37−37.
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2017
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2017
Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Teadlaste otselepingud ja vaesus. Sirp, 33−35.
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Aru, Juhan; Espak, Peeter; Grossberg, Maarja; Heinsalu, Els; Karjust, Kristo; Kogermann, Karin; Kurig, Heisi; Köster, Kajar; Küngas, Rainer; Leijen, Äli; Liiv, Innar; Milani, Lili; Mõtus, Kerli; Näripea, Eva; Ojavee, Kärt; Oras, Ester; Preegel, Gert; Purge, Priit; Raju, Marju; Raudla, Ringa ... Voll, Hendrik (2017). Kuhu viib teadlaste karjääriredel? Sirp, 7−8.
6.8.
2017
Lokk, Kaie; Vooder, Tõnu; Kolde, Raivo; Välk, Kristjan; Võsa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tõnisson, Neeme (2017). Correction: Methylation Markers of Early-Stage Non-Small Cell Lung Cancer. PLOS ONE, 12 (1), e0170833−e0170833.10.1371/journal.pone.0170833.
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2017
Lokk, Kaie; Vooder, Tonu; Kolde, Raivo; Valk, Kristjan; Vosa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tonisson, Neeme (2017). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer (vol 7, e39813, 2012). PLOS ONE, 1, ARTN e0170833.10.1371/journal.pone.0170833.
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2016
Lessard, Samuel; Manning, Alisa K; Low-Kam, Cécile; Auer, Paul L; Giri, Ayush; Graff, Mariaelisa; Schurmann, Claudia; Yaghootkar, Hanieh; Luan, Jian'an; Esko, Tonu; Karaderi, Tugce; Bottinger, Erwin P; Lu, Yingchang; Carlson, Chris; Caulfield, Mark; Dubé, Marie-Pierre; Jackson, Rebecca D; Kooperberg, Charles; McKnight, Barbara; Mongrain, Ian ... Lettre, Guillaume (2016). Testing the role of predicted gene knockouts in human anthropometric trait variation. Human Molecular Genetics, 25 (10), 1−11.10.1093/hmg/ddw055.
1.1.
2016
Ivanov, Maxim; Kals, Mart; Lauschke, Volker; Barragan, Isabel; Ewels, Philip; Käller, Max; Axelsson, Tomas; Lehtiö, Janne; Milani, Lili; Ingelman-Sundberg, Magnus (2016). Single base resolution analysis of 5-hydroxymethylcytosine in 188 human genes: implications for hepatic gene expression. Nucleic Acids Research, 44 (14), 6756−6769.doi:10.1093/nar/gkw316.
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2016
Franke, B; Stein, JL; Ripke, S; Anttila, V; Hibar, DP; van, Hulzen, KJ; Arias-Vasquez, A; Smoller, JW; Nichols, TE; Neale, MC; McIntosh, AM; Lee, P; McMahon, FJ; Meyer-Lindenberg, A; Mattheisen, M; Andreassen, OA; Gruber, O; Sachdev, PS; Roiz-Santiañez, R; Saykin, AJ ... Sullivan, PF . (2016). Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept. Nature Neuroscience, 19 (3), 420−433.10.1038/nn.4228.
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2016
Pettai, Kristi; Milani, Lili; Tammiste, Anu; Võsa, Urmo; Kolde, Raivo; Eller, Triin; Nutt, David; Metspalu, Andres; Maron, Eduard (2016). Whole-genome expression analysis reveals genes associated with treatment response to escitalopram in major depression. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 26 (9), 1475−1483.10.1016/j.euroneuro.2016.06.007.
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2016
Limbach, Maia; Saare, Mario; Tserel, Liina; Kisand, Kai; Eglit, Triin; Sauer, Sascha; Axelsson, Tomas; Syvänen, Ann-Christine; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2016). Epigenetic profiling in CD4+ and CD8+ T cells from Graves' disease patients reveals changes in genes associated with T cell receptor signaling. Journal of Autoimmunity, 67, 46−56.10.1016/j.jaut.2015.09.006.
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2016
Thiéry, Odile; Vasar, Martti; Jairus, Teele; Davison, John; Roux, Christophe; Kivistik, Paula-Ann; Metspalu, Andres; Milani, Lili; Saks, Ülle; Moora, Mari; Zobel, Martin; Öpik, Maarja (2016). Sequence variation in nuclear ribosomal small subunit, internal transcribed spacer and large subunit regions of Rhizophagus irregularis and Gigaspora margarita is high and isolate-dependent. Molecular Ecology, 25 (12), 2816−2832.10.1111/mec.13655.
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2016
Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement; Fontanillas, Pierre; Moutsianas, Loukas; McCarthy, Davis J; Rivas, Manuel A; Perry, John R B; Sim, Xueling; Blackwell, Thomas W; Robertson, Neil R; Rayner, N William; Cingolani, Pablo; Locke, Adam E; Tajes, Juan Fernandez; Highland, Heather M ... McCarthy, Mark I (2016). The genetic architecture of type 2 diabetes. Nature, 536 (7614), 41−47.10.1038/nature18642.
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2016
Okbay, Aysu; Beauchamp, Jonathan P; Fontana, Mark Alan; Lee, James J; Pers, Tune H; Rietveld, Cornelius A; Turley, Patrick; Chen, Guo-Bo; Emilsson, Valur; Meddens, S Fleur W; Oskarsson, Sven; Pickrell, Joseph K; Thom, Kevin; Timshel, Pascal; de Vlaming, Ronald; Abdellaoui, Abdel; Ahluwalia, Tarunveer S; Bacelis, Jonas; Baumbach, Clemens; Bjornsdottir, Gyda ... Benjamin, Daniel J (2016). Genome-wide association study identifies 74 loci associated with educational attainment. Nature, 533 (7604), 539−542.10.1038/nature17671.
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2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno (2016). Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (8), 856−866.10.1038/ng.3598.
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2016
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2016
Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stančáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D'Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N, Graff M, Grallert H, Grarup N, Gräßler J, Grewal J, Hamsten A, Harder MN, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Havulinna AS, Heliövaara M, Hillege H, Hofman A, Holmen O, Homuth G, Hottenga JJ, Hui J, Husemoen LL, Hysi PG, Isaacs A, Ittermann T, Jalilzadeh S, James AL, Jørgensen T, Jousilahti P, Jula A, Marie Justesen J, Justice AE, Kähönen M, Karaleftheri M, Tee Khaw K, Keinanen-Kiukaanniemi SM, Kinnunen L, Knekt PB, Koistinen HA, Kolcic I, Kooner IK, Koskinen S, Kovacs P, Kyriakou T, Laitinen T, Langenberg C, Lewin AM, Lichtner P, Lindgren CM, Lindström J, Linneberg A, Lorbeer R, Lorentzon M, Luben R, Lyssenko V, Männistö S, Manunta P, Leach IM, McArdle WL, Mcknight B, Mohlke KL, Mihailov E, Milani L, Mills R, Montasser ME, Morris AP, Müller G, Musk AW, Narisu N, Ong KK, Oostra BA, Osmond C, Palotie A, Pankow JS, Paternoster L, Penninx BW, Pichler I, Pilia MG, Polašek O, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rayner NW, Ribel-Madsen R, Rice TK, Richards M, Ridker PM, Rivadeneira F, Ryan KA, Sanna S, Sarzynski MA, Scholtens S, Scott RA, Sebert S, Southam L, Sparsø TH, Steinthorsdottir V, Stirrups K, Stolk RP, Strauch K, Stringham HM, Swertz MA, Swift AJ, Tönjes A, Tsafantakis E, van der Most PJ, Van Vliet-Ostaptchouk JV, Vandenput L, Vartiainen E, Venturini C, Verweij N, Viikari JS, Vitart V, Vohl MC, Vonk JM, Waeber G, Widén E, Willemsen G, Wilsgaard T, Winkler TW, Wright AF, Yerges-Armstrong LM, Hua Zhao J, Carola Zillikens M, Boomsma DI, Bouchard C, Chambers JC, Chasman DI, Cusi D, Gansevoort RT, Gieger C, Hansen T, Hicks AA, Hu F, Hveem K, Jarvelin MR, Kajantie E, Kooner JS, Kuh D, Kuusisto J, Laakso M, Lakka TA, Lehtimäki T, Metspalu A, Njølstad I, Ohlsson C, Oldehinkel AJ, Palmer LJ, Pedersen O, Perola M, Peters A, Psaty BM, Puolijoki H, Rauramaa R, Rudan I, Salomaa V, Schwarz PE, Shudiner AR, Smit JH, Sørensen TI, Spector TD, Stefansson K, Stumvoll M, Tremblay A, Tuomilehto J, Uitterlinden AG, Uusitupa M, Völker U, Vollenweider P, Wareham NJ, Watkins H, Wilson JF, Zeggini E, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, van Duijn CM, Fox C, Groop LC, Heid IM, Hunter DJ, Kaplan RC, McCarthy MI, North KE, O'Connell JR, Schlessinger D, Thorsteinsdottir U, Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJ. (2016). A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nature Communications, e13357, 1−11.10.1038/ncomms13357.
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2016
Guerra, D.; Ghiselli, F.; Milani, L.; Breton, S.; Passamonti, M. (2016). Early replication dynamics of sex-linked mitochondrial DNAs in the doubly uniparental inheritance species Ruditapes philippinarum (Bivalvia Veneridae). Heredity, 116 (3), 314−322.10.1038/hdy.2015.105.
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2016
Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G; Social Science Genetic Association Consortium, Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences of the United States of America, 113 (47), 13366−13371.10.1073/pnas.1605334113.
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2016
Sekar, Aswin; Bialas, Allison R.; de Rivera, Heather; Davis, Avery; Hammond, Timothy R.; Kamitaki, Nolan; Tooley, Katherine; Presumey, Jessy; Baum, Matthew; Van Doren, Vanessa; Genovese, Giulio; Rose, Samuel A.; Handsaker, Robert E.; Daly, Mark J.; Carroll, Michael C.; Stevens, Beth; McCarroll, Steven A. (2016). Schizophrenia risk from complex variation of complement component 4. Nature, 530 (7589), 177−194.10.1038/nature16549.
5.1.
2016
Tasa, Tonis; Metsvaht, Tuuli; Kalamees, Riste; Milani, Lili; Vilo, Jaak; Lutsar, Irja (2016). Personalised Bayesian Dose Adjustment of Vancomycin in Neonates. Human Heredity, 81 (4), 236−236.
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2016
Peterson, P.; Tserel, L.; Kolde, R.; Limbach, M.; Tretyakov, K.; Kasela, S.; Kisand, K.; Saare, M.; Vilo, J.; Metspalu, A.; Milani, L. (2016). Age-related profiling of DNA methylation in CD8+T cells reveals changes in immune response and transcriptional regulator genes. European Journal of Immunology, 879−879.
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2016
Kantojarvi, K.; Liuhanen, J.; Saarenpaa-Heikkila, O.; Satomaa, A. -L; Kylliainen, A.; Polkki, P.; Jaatela, J.; Milani, L.; Himanen, S. -L.; Porkka-Heiskanen, T.; Paavonen, J.; Paunio, T. (2016). Variants in CACNA1C are associated with sleep regulation in infants. European Neuropsychopharmacology, 192−192.WOS:000413843800345.
6.8.
2016
Gormley, Padhraig; Anttila, Verneri; Winsvold, Bendik S; Palta, Priit; Esko, Tonu; Pers, Tune H; Farh, Kai-How; Cuenca-Leon, Ester; Muona, Mikko; Furlotte, Nicholas A; Kurth, Tobias; Ingason, Andres; McMahon, George; Ligthart, Lannie; Terwindt, Gisela M; Kallela, Mikko; Freilinger, Tobias M; Ran, Caroline; Gordon, Scott G; Stam, Anine H ... Palotie, Aarno. (2016). Corrigendum: Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine. Nature Genetics, 48 (10), 1296−1296.10.1038/ng1016-1296c.
6.8.
2016
Nikopensius, T.; Saag, M.; Jagomagi, T.; Annilo, T.; Kals, M.; Kivistik, P. A.; Milani, L.; Metspalu, A. (2016). A missense mutation in DUSP6 is associated with Class III malocclusion (vol 92, pg 893, 2013). Journal Of Dental Research, 8, 955−955.10.1177/0022034516651438.
1.1.
2015
Westra, HJ; Arends, D; Esko, T; Peters, MJ; Schurmann, C; Schramm, K; Kettunen, J; Yaghootkar, H; Fairfax, BP; Andiappan, AK; Li, Y; Fu, J; Karjalainen, J; Platteel, M; Visschedijk, M; Weersma, RK; Kasela, S; Milani, L; Tserel, L; Peterson, P ... Franke, L. (2015). Cell Specific eQTL Analysis without Sorting Cells. PLOS Genetics, 11 (5), e1005223.10.1371/journal.pgen.1005223.
1.1.
2015
Bulik-Sullivan, BK.; Loh, PR.; Finucane, HK.; Ripke, S.; Yang, J.; Schizophrenia Working Group of the Psychiatric, Genomics Consortium; Patterson, N.; Daly, MJ.; Price, AL.; Neale, BM. (2015). LD Score regression distinguishes confounding from polygenicity in genome-wide association studies. Nature Genetics, 47 (3), 291−295.10.1038/ng.3211.
1.1.
2015
Peyrot, WJ; Lee, SH; Milaneschi, Y; Abdellaoui, A; Byrne, EM; Esko, T; de, Geus, EJ; Hemani, G; Hottenga, JJ; Kloiber, S; Levinson, DF; Lucae, S; Martin, NG; Medland, SE; Metspalu, A; Milani, L; Noethen, MM; Potash, JB; Rietschel, M; Rietveld, CA ... SSGAC, Corporate, Collaborator. (2015). The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects. Molecular Psychiatry, 20 (6), 735−743.10.1038/mp.2015.50.
1.1.
2015
Huan, Tianxiao; Esko, Tõnu; Peters, Marjolein J; Pilling, Luke C; Schramm, Katharina; Schurmann, Claudia; Chen, Brian H; Liu, Chunyu; Joehanes, Roby; Johnson, Andrew D; Yao, Chen; Ying, Sai-Xia; Courchesne, Paul; Milani, Lili; Raghavachari, Nalini; Wang, Richard; Liu, Poching; Reinmaa, Eva; Dehghan, Abbas; Hofman, Albert ... Levy, Daniel. (2015). A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension. PLOS Genetics, 11 (3), e1005035.10.1371/journal.pgen.1005035.
1.1.
2015
Zhu, Z; Bakshi, A; Vinkhuyzen, AA; Hemani, G; Lee, SH; Nolte, IM; van, Vliet-Ostaptchouk, JV; Snieder, H; The, LifeLines, Cohort, Study; Esko, T; Milani, L; Mägi, R; Metspalu, A; Hill, WG; Weir, BS; Goddard, ME; Visscher, PM; Yang, J. (2015). Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits. American Journal of Human Genetics, 96 (3), 377−85.10.1016/j.ajhg.2015.01.001.
1.1.
2015
Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Locke, AE; Mägi, R; Strawbridge, RJ; Pers, TH; Fischer, K; Justice, AE; Workalemahu, T; Wu, JM; Buchkovich, ML; Heard-Costa, NL; Roman, TS; Drong, AW; Song, C; Gustafsson, S; Day, FR; Esko, T ... Mohlke, KL. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187−196.10.1038/nature14132.
1.1.
2015
Putku, Margus; Kals, Mart; Inno, Rain; Kasela, Silva; Org, Elin; Kožich, Viktor; Milani, Lili; Laan, Maris (2015). CDH13 promoter SNPs with pleiotropic effect on cardiometabolic parameters represent methylation QTLs. Human Genetics, 134 (3), 291−303.10.1007/s00439-014-1521-6.
1.1.
2015
Milani, Lili; Leitsalu, Liis; Metspalu, Andres (2015). An epidemiological perspective of personalized medicine: the Estonian experience. Journal of Internal Medicine, 277 (2), 188−200.10.1111/joim.12320.
1.1.
2015
The, Coffee, and, Caffeine, Genetics, Consortium; Cornelis, MC; Byrne, EM; Esko, T; Nalls, MA; Ganna, A; Paynter, N; Monda, KL; Amin, N; Fischer, K; Renstrom, F; Ngwa, JS; Huikari, V; Cavadino, A; Nolte, IM; Teumer, A; Yu, K; Marques-Vidal, P; Rawal, R; Manichaikul, A ... Chasman, DI. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647−656.10.1038/mp.2014.107.
1.1.
2015
Yang, J; Bakshi, A; Zhu, Z; Hemani, G; Vinkhuyzen, AAE; Lee, SH (; Robinson, MR; Perry, JRB; Nolte, IM; van Vliet-Ostaptchouk, JV; Snieder, H; Esko, T; Milani, L; Magi, R; Metspalu, A; Hamsten, A; Magnusson, PKE; Pedersen, NL; Ingelsson, E; Soranzo, N ... Visscher, PM. (2015). Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index. Nature Genetics, 47 (10), 1114−1120.10.1038/ng.3390.
1.1.
2015
Kato, N; Loh, M; Takeuchi, F; Verweij, N; Wang, X; Zhang, W; Kelly, TN; Saleheen, D; Lehne, B; Mateo, Leach, I; Drong, AW; Abbott, J; Wahl, S; Tan, ST; Scott, WR; Campanella, G; Chadeau-Hyam, M; Afzal, U; Ahluwalia, TS; Bonder, MJ ... Chambers, JC. (2015). Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nature Genetics, 47 (11), 1282−1293.10.1038/ng.3405.
1.1.
2015
Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F.; Chu, Su; Czajkowski, Jacek; Esko, Tonu; Fall, Tove; Kilpelainen, Tuomas O.; Lu, Yingchang; Magi, Reedik; Mihailov, Evelin; Pers, Tune H.; Rueeger, Sina; Teumer, Alexander; Ehret, Georg B.; Ferreira, Teresa; Heard-Costa, Nancy L.; Karjalainen, Juha ... Loos, Ruth J. F. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLOS Genetics, 11 (10), ARTN e1005378.10.1371/journal.pgen.1005378.
1.1.
2015
Locke, AE.; Kahali, B.; Berndt, SI.; Justice, AE.; Pers, TH.; Day, FR.; Powell, C.; Vedantam, S.; Buchkovich, ML.; Yang, J.; Croteau-Chonka, DC.; Esko, T.; Fall, T.; Ferreira, T.; Gustafsson, S.; Kutalik, Z.; Luan, J.; Mägi, R.; Randall, JC.; Winkler, TW. ... Speliotes, EK. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197−206.10.1038/nature14177.
1.1.
2015
Day, Felix R; Ruth, Katherine S; Thompson, Deborah J; Lunetta, Kathryn L; Pervjakova, Natalia; Chasman, Daniel I; Stolk, Lisette; Finucane, Hilary K; Sulem, Patrick; Bulik-Sullivan, Brendan; Esko, Tõnu; Johnson, Andrew D; Elks, Cathy E; Franceschini, Nora; He, Chunyan; Altmaier, Elisabeth; Brody, Jennifer A; Franke, Lude L; Huffman, Jennifer E; Keller, Margaux F ... Murray, Anna (2015). Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47 (11), 1294−303.10.1038/ng.3412.
1.1.
2015
Peters, Marjolein J.; Joehanes, Roby; Pilling, Luke C.; Schurmann, Claudia; Conneely, Karen N.; Powell, Joseph; Reinmaa, Eva; Sutphin, George L.; Zhernakova, Alexandra; Schramm, Katharina; Wilson, Yana A.; Kobes, Sayuko; Tukiainen, Taru; Ramos, Yolande F.; Goering, Harald H. H.; Fornage, Myriam; Liu, Yongmei; Gharib, Sina A.; Stranger, Barbara E.; De Jager, Philip L. ... Johnson, Andrew D. (2015). The transcriptional landscape of age in human peripheral blood. Nature Communications, 6, ARTN 8570.10.1038/ncomms9570.
1.1.
2015
Tserel, Liina; Kolde, Raivo; Limbach, Maia; Tretyakov, Konstantin; Kasela, Silva; Kisand, Kai; Saare, Mario; Vilo, Jaak; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2015). Age-related profiling of DNA methylation in CD8+ T cells reveals changes in immune response and transcriptional regulator genes. Scientific Reports, 5 (13107), 1−11.10.1038/srep13107.
1.1.
2015
Leitsalu, Liis; Haller, Toomas; Esko, Tõnu; Tammesoo, Mari-Liis; Alavere, Helene; Snieder, Harold; Perola, Markus; Ng, Pauline C; Mägi, Reedik; Milani, Lili; Fischer, Krista; Metspalu, Andres (2015). Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu. International Journal of Epidemiology, 44 (4), 1137−1147.10.1093/ije/dyt268.
1.1.
2015
Day, Felix R.; Ruth, Katherine S.; Thompson, Deborah J.; Lunetta, Kathryn L.; Pervjakova, Natalia; Chasman, Daniel I.; Stolk, Lisette; Finucane, Hilary K.; Sulem, Patrick; Bulik-Sullivan, Brendan; Esko, Tonu; Johnson, Andrew D.; Elks, Cathy E.; Franceschini, Nora; He, Chunyan; Altmaier, Elisabeth; Brody, Jennifer A.; Franke, Lude L.; Huffman, Jennifer E.; Keller, Margaux F. ... Murray, Anna (2015). Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair EDITORIAL COMMENT. Obstetrical & Gynecological Survey, 12, 758−762.10.1097/01.ogx.0000473766.71624.99.
1.1.
2015
Yang, Jian; Bakshi, Andrew; Zhu, Zhihong; Hemani, Gibran; Vinkhuyzen, Anna A E; Nolte, Ilja M; van Vliet-Ostaptchouk, Jana V; Snieder, Harold; , ; Esko, Tonu; Milani, Lili; Mägi, Reedik; Metspalu, Andres; Hamsten, Anders; Magnusson, Patrik K E; Pedersen, Nancy L; Ingelsson, Erik; Visscher, Peter M (2015). Genome-wide genetic homogeneity between sexes and populations for human height and body mass index. Human Molecular Genetics, 24 (25), 7445−7449.10.1093/hmg/ddv443.
1.1.
2015
Joshi, Peter K.; Esko, Tõnu; Mattsson, Hannele; Eklund, Niina; Gandin, Ilaria; Nutile, Teresa; Jackson, Anne U.; Schurmann, Claudia; Smith, Albert V.; Zhang, Weihua; Okada, Yukinori; Stancakova, Alena; Faul, Jessica D.; Zhao, Wei; Bartz, Traci M.; Concas, Maria Pina; Franceschini, Nora; Enroth, Stefan; Vitart, Veronique; Trompet, Stella ... Wilson, James F. (2015). Directional dominance on stature and cognition in diverse human populations. Nature, 523 (7561), 459−476.10.1038/nature14618.
6.6.
2015
Milani, L. (2015). Toome geenid lauale. Sirp.
6.8.
2015
Benyamin, B; Esko, T; Ried, JS; Radhakrishnan, A; Vermeulen, SH; Traglia, M; Gögele, M; Anderson, D; Broer, L; Podmore, C; Luan, J; Kutalik, Z; Sanna, S; van, der, Meer, P; Tanaka, T; Wang, F; Westra, HJ; Franke, L; Mihailov, E; Milani, L ... Whitfield, JB. (2015). Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications, 6, ARTN 6542.10.1038/ncomms7542.
1.1.
2014
Benyamin, B; Esko, T; Ried, JS; Radhakrishnan, A; Vermeulen, SH; Traglia, M; Gögele, M; Anderson, D; Broer, L; Podmore, C; Luan, J; Kutalik, Z; Sanna, S; van, der, Meer, P; Tanaka, T; Wang, F; Westra, HJ; Franke, L; Mihailov, E; Milani, L ... Whitfield, JB. (2014). Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. Nature Communications, 5 (4926), 1−7.10.1038/ncomms5926.
1.1.
2014
Knappskog, S.; Gansmo, L.B.; Dibirova, K.; Metspalu, A.; Cybulski, C.; Peterlongo, P.; Aaltonen, L.; Vatten, L.; Romundstad, P.; Hveem, K.; Devilee, P.; Evans, G.D.; Lin, D.; Van, Camp, G.; Manolopoulos, V.G.; Osorio, A.; Milani, L.; Ozcelik, T.; Zalloua, P.; Mouzaya, F. ... Lønning, P.E. (2014). Population, distribution, and, ancestry, of, the, cancer, protective, MDM2, SNP285, (rs117039649). Oncotarget, 5 (18), 8224−8234.
1.1.
2014
Bonder, MJ; Kasela, S; Kals, M; Tamm, R; Lokk, K; Barragan, I; Buurman, WA; Deelen, P; Greve, J-W; Ivanov, M; Rensen, SS; van Vliet-Ostaptchouk, JV; Wolfs, MG; Fu, J; Hofker, MH; Wijmenga, C; Zhernakova, A; Ingelman-Sundberg, M; Lude Franke, L; Milani, L. (2014). Genetic and epigenetic regulation of gene expression in fetal and adult human livers. BMC Genomics, 15 (860), 1−28.10.1186/1471-2164-15-860.
1.1.
2014
Dumas, O.; Laurent, E.; Bousquet, J.; Metspalu, A.; Milani, L.; Kauffmann, F.; Le Moual, N. (2014). Occupational irritants and asthma: an Estonian cross-sectional study of 34 000 adults. European Respiratory Journal, 44 (3), 647−656.10.1183/09031936.00172213.
1.1.
2014
González, JR; Cáceres, A; Esko, T; Cuscó, I; Puig, M; Esnaola, M; Reina, J; Siroux, V; Bouzigon, E; Nadif, R; Reinmaa, E; Milani, L; Bustamante, M; Jarvis, D; Antó, JM; Sunyer, J; Demenais, F; Kogevinas, M; Metspalu, A; Cáceres, M ... Pérez-Jurado, LA. (2014). A Common 16p11.2 Inversion Underlies the Joint Susceptibility to Asthma and Obesity. American Journal of Human Genetics, 94 (3), 361−372.10.1016/j.ajhg.2014.01.015.
1.1.
2014
Perry, J.R.B.; Day, F.; Elks, C.E.; Sulem, P.; Thompson, D.J.; Ferreira, T.; He, C.; Chasman, D.I.; Esko, T.; Thorleifsson, G.; Albrecht, E.; Ang, W.Q.; Corre, T.; Cousminer, D.L.; Feenstra, B.; Franceschini, N.; Ganna, A.; Johnson, A.D.; Kjellqvist, S.; Lunetta, K.L. ... Ong, K.K. (2014). Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature, 514 (7520), 92.10.1038/nature13545.
1.1.
2014
Schizophrenia Working Group of the Psychiatric Genomics Consortium ... Metspalu, A; Milani, L; Nelis, M; Esko, T. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511 (7510), 421−427.10.1038/nature13595.
1.1.
2014
Metsalu, Tauno; Viltrop, Triin; Tiirats, Airi; Rajashekar, Balaji; Reimann, Ene; Kõks, Sulev; Rull, Kristiina; Milani, Lili; Acharya, Ganesh; Basnet, Purusotam; Vilo, Jaak; Mägi, Reedik; Metspalu, Andres; Peters, Maire; Haller-Kikkatalo, Kadri; Salumets, Andres (2014). Using RNA sequencing for identifying gene imprinting and random monoallelic expression in human placenta. Epigenetics, 9 (10), 1397−1409.10.4161/15592294.2014.970052.
1.1.
2014
Winkler, T.W.; Day, FR.; Croteau-Chonka, DC.; Wood, AR.; Locke, AE.; Magi, R.; Ferreira, T.; Fall, T.; Graff, M.; Justice, AE.; Luan, JA.; Gustafsson, S.; Randall, JC.; Vedantam, S.; Workalemahu, T.; Kilpelainen, TO.; Scherag, A.; Esko, T.; Kutalik, Z.; Heid, IM. ... Loos, RJF (2014). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5), 1192−1212.10.1038/nprot.2014.071.
1.1.
2014
Tserel, Liina; Limbach, Maia; Saare, Mario; Kisand, Kai; Metspalu, Andres; Milani, Lili; Peterson, Pärt (2014). CpG sites associated with NRP1, NRXN2 and miR-29b-2 are hypomethylated in monocytes during ageing. Immunity and Ageing, 11 (1), Article Number: 1 (1-5).
1.1.
2014
Evangelou, E; Kerkhof, HJ; Styrkarsdottir, U; Ntzani, EE; Bos, SD; Esko, T; Evans, DS; Metrustry, S; Panoutsopoulou, K; Ramos, YF; Thorleifsson, G; Tsilidis, KK; arcOGEN, Consortium; Arden, N; Aslam, N; Bellamy, N; Birrell, F; Blanco, FJ; Carr, A; Chapman, K ... Valdes, AM. (2014). A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Annals of Rheumatic Diseases, 73 (12), 2130−2136.10.1136/annrheumdis-2012-203114.
1.1.
2014
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y14; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J ... Frayling, TM. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173−1186.10.1038/ng.3097.
1.1.
2014
Knappskog, Stian; Gansmo, Liv B.; Dibirova, Khadizha; Metspalu, Andres; Cybulski, Cezary; Peterlongo, Paolo; Aaltonen, Lauri; Vatten, Lars; Romundstad, Pal; Hveem, Kristian; Devilee, Peter; Evans, Gareth D.; Lin, Dongxin; Van Camp, Guy; Manolopoulos, Vangelis G.; Osorio, Ana; Milani, Lili; Ozcelik, Tayfun; Zalloua, Pierre; Mouzaya, Francis ... Lonning, Per E. (2014). Population distribution and ancestry of the cancer protective MDM2 SNP285 (rs117039649). Oncotarget, 5 (18), 8223−8234.
1.1.
2014
Kretschmer, A.; Moeller, G.; Lee, H.; Laumen, H.; von Toerne, C.; Schramm, K.; Prokisch, H.; Eyerich, S.; Wahl, S.; Baurecht, H.; Franke, A.; Claussnitzer, M.; Eyerich, K.; Teumer, A.; Milani, L.; Klopp, N.; Hauck, S. M.; Illig, T.; Peters, A.; Waldenberger, M. ... Weidinger, S. (2014). A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding. Allergy, 69 (5), 632−642.10.1111/all.12394.
5.1.
2014
Viltrop, T.; Metsalu, T.; Tiirats, A.; Rajashekar, B.; Reimann, E.; Koks, S.; Rull, K.; Milani, L.; Vilo, J.; Maegi, R.; Metspalu, A.; Peters, M.; Haller-Kikkatalo, K.; Salumets, A. (2014). Imprinting landscape of human placenta as discovered by whole transcriptome RNA-sequencing and exome variant data analysis. Human Reproduction, 29, 72−72.
1.1.
2013
Ivanov, M; Kals, M; Kacevska, M; Barragan, I; Kasuga, K; Rane, A; Metspalu, A; Milani, L; Ingelman-Sundberg, M. (2013). Ontogeny, distribution and potential roles of 5-hydroxymethylcytosine in human liver function. Genome Biology, 14 (8), R83.
1.1.
2013
Westra, HJ; Peters, MJ; Esko, T; Yaghootkar, H; Schurmann, C; Kettunen, J; Christiansen, MW; Fairfax, BP; Schramm, K; Powell, JE; Zhernakova, A; Zhernakova, DV; Veldink, JH; Van den Berg, LH; Karjalainen, J; Withoff, S; Uitterlinden, AG; Hofman, A; Rivadeneira, F; 't Hoen, PA ... Franke, L. (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45 (10), 1238−U195.10.1038/ng.2756.
1.1.
2013
Nikopensius, T; Saag, M; Jagomägi, T; Annilo, T; Kals, M; Kivistik, P.A; Milani, L; Metspalu, A. (2013). A Missense Mutation in DUSP6 is Associated with Class III Malocclusion. Journal of Dental Research, 92 (10), 893−898.10.1177/0022034513502790.
1.1.
2013
Rietveld, CA; Medland, SE; Derringer, J; Yang, J; Esko, T; Martin, NW; Westra, HJ; Shakhbazov, K; Abdellaoui, A; Agrawal, A; Albrecht, E; Alizadeh, BZ; Amin, N; Barnard, J; Baumeister, SE; Benke, KS; Bielak, LF; Boatman, JA; Boyle, PA; Davies, G ... Koellinger, PD. (2013). GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science, 340 (6139), 1467−1471.10.1126/science.1235488.
1.1.
2013
den Hoed, M; Eijgelsheim, M; Esko, T; Brundel, BJ; Peal, DS; Evans, DM; Nolte, IM; Segrè, AV; Holm, H; Handsaker, RE; Westra, HJ; Johnson, T; Isaacs, A; Yang, J; Lundby, A; Zhao, JH; Kim, YJ; Go, MJ; Almgren, P; Bochud, M ... Loos, RJ. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6), 621.
1.1.
2013
Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69.10.1038/ng.2606.
1.1.
2013
Ivanov, Mart; Kals, Mart; Kacevska, Marina; Metspalu, Andres; Ingelman-Sundberg, Magnus; Milani, Lili. (2013). In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes. Nucleic Acids Research, 2013/01/15, 1−9.
1.1.
2013
Perry, JR; Corre, T; Esko, T; Chasman, DI; Fischer, K; Franceschini, N; He, C; Kutalik, Z; Mangino, M; Rose, LM; Smith, AV; Stolk, L; Sulem, P; Weedon, MN; Zhuang, WV; Arnold, A; Ashworth, A; Bergmann, S; Buring, JE; Burri, A ... Murray, A (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Human Molecular Genetics, 22(7) (1), 1465−1472.10.1093/hmg/dds551.
1.1.
2012
Kacevska, Marina; Ivanov, Maxim; Wyss, Annika; Kasela, Silva; Milani, Lili; Rane, Anders; Ingelman-Sundberg, Magnus (2012). DNA methylation dynamics in the hepatic CYP3A4 gene promoter. Biochimie, 94 (11), 2338−2344.10.1016/j.biochi.2012.07.013.
1.1.
2012
McQuillan, R.; Eklund, N.; Pirastu, N.; Kuningas, M.; McEvoy, BP.; Esko, T.; Corre, T.; Davies, G.; Kaakinen, M.; Lyytikäinen, LP.; Kristiansson, K.; Havulinna, AS.; Gögele, M.; Vitart, V.; Tenesa, A.; Aulchenko, Y.; Hayward, C.; Johansson, A.; Boban, M.; Ulivi, S. ... on behalf of the ROHgen, Consortium. (2012). Evidence of Inbreeding Depression on Human Height. PLOS Genetics, 8 (7), e1002655.10.1371/journal.pgen.1002655.
1.1.
2012
Lokk, Kaie; Vooder, Tõnu; Kolde, Raivo; Välk, Kristjan; Võsa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltšina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tõnisson, Neeme (2012). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer. PLOS ONE, 7 (6), e39813− .10.1371/journal.pone.0039813.
1.1.
2012
Nordlund, J.; Milani, L.; Lundmark, A.; Lönnerholm, G.; Syvänen, AC. (2012). DNA methylation analysis of bone marrow cells at diagnosis of acute lymphoblastic leukemia and at remission. PLoS ONE, 7 (4), e34513.
5.1.
2012
Tserel, L.; Saare, M.; Kisand, K.; Milani, L.; Metspalu, A.; Peterson, P. (2012). Patterns of DNA methylation in the T-cells and monocytes from the elderly and the young. Immunology, 137, 432−433.
5.2.
2012
Tõnisson, N.; Lokk, K.; Vooder, T.; Kolde, R.; Välk, K.; Roosipuu, R.; Võsa, U.; Milani, L.; Fischer, K.; Koltšina, M.; Urgard, E.; Annilo, T.; Metspalu, A. (2012). Altered DNA methylation in early-stage non-small-cell lung cancer. European Journal of Human Genetics: European Human Genetics Conference; Nürnberg, Saksamaa; 23.–26. juuni, 2012. Nature Publishing Group, 174−174. (20; Suppl 1).
6.7.
2012
Kaasik, Aidula-Taie; Keis, Aime; Metspalu, Andres; Allik, Annely; Mölder, Ene; Leego, Erkki; Alavere, Helene; Lilienthal, Kadri Fischer, Krista; Leitsalu-Moynihan, Liis; Milani, Lili; Tammesoo, Mari-Liis; Väli-Täht, Maris; Leego, Merike; Hass, Merli; Tamm, Riin; Nikopensius, Tiit; Esko, Tõnu; Haller, Toomas (2012). Estonian Genome Center : 2001-2011. Tartu: University of Tartu.
3.2.
2011
Metspalu, A.; Leitsalu, L.; Milani, L.; Esko, T.; Allik, A.; Lilienthal, M.-L.; Haller, T.; Kaasik, A.-T.;Nelis, M.; Hass, M.; Fischer, K.; Krjutškov, K.; Leego, E.; Alavere, H.; Perola, M. (2011). The Estonian biobank - the gateway for the stratified medicine. In: Engelbrecht, J. (Ed.). Research in Estonia. Present and future. (283−301).. Tallinn: Estonian Academy of Sciences.
1.1.
2010
Milani, L.; Lundmark, A.; Kiialainen, A.; Nordlund, J.; Flaegstad, T.; Forestier, E.; Heyman, M.; Jonmundsson, G.; Kanerva, J.; Schmiegelow, K.; Söderhäll, S.; Gustafsson, M. G.; Lönnerholm, G.; Syvänen, A. C. (2010). DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia. Blood, 115 (6), 1214−1225.10.1182/blood-2009-04-214668.
1.1.
2009
Mukonzo, J. K.; Roshammar, D.; Waako, P.; Andersson, M.; Fukasawa, T.; Milani, L.; Svensson, J. O.;Ogwal-Okeng, J.;Gustafsson, L. L.;Aklillu, E. (2009). A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans. British Journal of Clinical Pharmacology, 68, 690−699.
1.1.
2009
Ghotbi R, Gomez A, Milani L, Tybring G, Syvänen A-C, Bertilsson L, Ingelman-Sundberg M, Aklillu E (2009). Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers. The pharmacogenomics journal, 9 (3), 208−217.10.1038/tpj.2009.4.
1.1.
2009
Milani, L.; Lundmark, A.; Nordlund, J.; Kiialainen, A.; Flaegstad, T.; Jonmundsson, G.; Kanerva, J.; Schmiegelow, K.; Gunderson, K.L.; Lönnerholm, G.; Syvänen, A-C. (2009). Allele-specific gene expression patterns in primary leukemic cells reveal regulation of gene expression by CpG site methylation. Genome Research, 19 (1), 1−11.10.1101/gr.083931.108.
3.1.
2009
Milani, Lili; Syvänen, Ann-Christine. (2009). Genotyping single nucleotide polymorphisms by multiplex minisequencing using tag-arrays. In: DNA Microarrays for Biomedical Research (215−229).. Humana Press. (Methods in Molecular Biology).
1.1.
2008
Schnorrer, F.; Ahlford, A.; Chen, D.; Milani, L.; Syvänen, AC. (2008). Positional cloning by fast-track SNP-mapping in Drosophila melanogaster. Nature Protocols, 3 (11), 1751−1765.10.1038/nprot.2008.175.
1.1.
2008
Kristjansdottir, G.; Sandling, JK.; Bonetti, A.; Roos, IM.; Milani, L.; Wang, C.; Gustafsdottir, SM.; Sigurdsson, S.; Lundmark, A.; Tienari, PJ.; Koivisto, K.; Elovaara, I.; Pirttilä, T.; Reunanen, M.; Peltonen, L.; Saarela, J.; Hillert, J.; Olsson, T.; Landegren, U.; Alcina, A. ... Syvänen, A-C. (2008). Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations. Journal of Medical Genetics, 45 (6), 362−369.
1.1.
2008
Sigurdsson, S.; Goring, HH.; Kristjansdottir, G.; Milani, L.; Nordmark, G.; Sandling, JK.; Eloranta, ML.; Feng, D.; Sangster-Guity, N.; Gunnarsson, I.; Svenungsson, E.; Sturfelt, G.; Jonsen, A.; Truedsson, L.; Barnes, BJ.; Alm, G.; Rönnblom, L.; Syvänen, A-C.. (2008). Comprehensive evaluation of the genetic variants of interferon regulatory factor 5 (IRF5) reveals a novel 5 bp length polymorphism as strong risk factor for systemic lupus erythematosus. Human Molecular Genetics, 17 (6), 872−881.10.1093/hmg/ddm359.
1.1.
2008
Gupta M, Milani L, Hermansson M, Simonsson B, Markevarn B, Syvänen A-C, Barbany G. (2008). Expression of BCR-ABL1 oncogene relative to ABL1 gene changes overtime in chronic myeloid leukemia. Biochemical and Biophysical Research Communications, 366 (3), 848−851.10.1016/j.bbrc.2007.12.029.
1.1.
2007
Dideberg, V; Kristjansdottir, G; Milani, L; Libioulle, C; Sigurdsson, S; Louis, E; Wiman, AC; Vermeire, S; Rutgeerts, P; Belaiche, J; Franchimont, D; Van Gossum, A; Bours, V; Syvänen, A-C. (2007). An insertion-deletion polymorphism in the interferon regulatory Factor 5 (IRF5) gene confers risk of inflammatory bowel diseases. Human Molecular Genetics, 16 (24), 3008−3016.10.1093/hmg/ddm259.
1.1.
2007
Milani L, Gupta M, Andersen M, Dhar S, Fryknäs M, Isaksson A, Larsson R, Syvänen A-C. (2007). Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells. Nucleic Acids Research, 35, e34−e34.10.1093/nar/gkl1152.
1.1.
2006
Milani L, Fredriksson M, Syvänen A-C. (2006). Detection of alternatively spliced transcripts in leukemia cell lines by minisequencing on microarrays. Clinical Chemistry, 52, 202−211.10.1373/clinchem.2005.062042.

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