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Tõnu Margus

https://www.etis.ee/CV/Tõnu_Margus/est
tmargus@ebc.ee

Teenistuskäik

Töökohad ja ametid
1981a. lõpetanud Tartu H.Trefneri nimelise gümnaasiumi.
1981a. vastu võetud Tartu Ülikooli Bioloogia-Geograafia teaduskonda bioloogia erialale.
1983 a.tööl molekularbioloogia laboris. Esimene juhendaja Tago Sarapuu.
1986 a. lõpetanud Tartu Ülikooli bioloogia teaduskonna geneetika erialal. Kaitstud diplomitöö teemal “ t-RNA’e seondumine E.coli ribosoomidega.”
1986 a. asunud tööle KBFI molekulaargeneetika sektorisse Tartus.
1997 a. asus töötle bioinformaatika konsultandina Eesti Biokeskuses ja arvutiadministraatorina TÜMRI's
2005 a. arvutispetsialist TÜMRI's ja spetsialist TÜTI's
01.02.2014–31.01.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, bioinformaatika teadur (1,00)
01.09.2007–31.05.2008   
Eesti Biokeskus, Arvutihoolduse spetsialist (0,20)
01.05.2005–31.12.2007   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut, spetsialist (0,50)
01.05.2005–31.08.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, arvutispetsialist (0,50)
1997–2007   
Eesti Biokeskus, bioinformaatika spetsialist (0,20)
 
 
Haridustee
2007–2013   
geenitehnoloogia bioinformaatika doktorant
1981–1986   
Tartu Ülikool Bioloogia ja Geograafia teaduskond

Kvalifikatsioon

Teaduskraadid
Tõnu Margus, doktorikraad, 2013, (juh) Tanel Tenson; Maido Remm, Distribution and phylogeny of the bacterial translational GTPases and the Mqsr/YgiT regulatory system (Translatsiooniliste GTPaaside ja Mqsr/YgiT regulatoorse süsteemi levik ning evolutsioon bakterites), Tartu Ülikool.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS KLASSIFIKAATOR: B110 Bioinformaatika, meditsiiniinformaatika, biomatemaatika, biomeetrika
 
 
Lisainfo
bakalaureus
Tartu Ülikool

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2014
Huik, K.; Avi, R.; Uibopuu, H.; Pauskar, M.; Margus, T.; Karki, T.; Krispin, T.; Kool, P.; Rüütel, K.; Talu, A.; Abel-Ollo, K.; Uusküla, A.; Carrillo, AQ.; He, W.; Ahuja, SK.; Lutsar, I. (2014). Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population. Jaids-Journal of Acquired Immune Deficiency Syndromes, 66 (3), 239−244. DOI: 10.1097/QAI.0000000000000127.
1.1.
2013
Rull, Kristiina; Christiansen, Ole Bjarne; Nagirnaja, Liina; Steffensen, Rudi; Margus, Tõnu; Laan, Maris (2013). A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage. Fertility and Sterility, 99 (7), 1930−1936. DOI: 10.1016/j.fertnstert.2013.02.019.
1.1.
2013
Keis, M; Remm, J; Ho, SYW; Davison, J; Tammeleht, E; Tumanov, IL; Saveljev, AP; Männil, P; Kojola, I; Abramov, AV; Margus, T; Saarma, U. (2013). Complete mitochondrial genomes and a novel spatial genetic method reveal cryptic phylogeographic structure and migration patterns among brown bears in north-western Eurasia. Journal of Biogeography, 40 (5), 915−927.10.1111/jbi.12043.
1.1.
2011
Margus, T.; Remm, M.; Tenson, T. (2011). A Computational Study of Elongation Factor G (EFG) Duplicated Genes: Diverged Nature Underlying the Innovation on the Same Structural Template. PLoS ONE, 6, e22789.
1.1.
2010
Kasari, V.; Kurg, K.; Margus, T.; Tenson, T.; Kaldalu, N. (2010). The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. Journal of Bacteriology, 192 (11), 2908−2919. DOI: 10.1128/JB.01266-09.
1.1.
2009
Loogväli, E-L.; Kivisild, T.; Margus, T.; Villems, R. (2009). Explaining the imperfection of the molecular clock of hominid mitochondria. PLoS ONE, e8260. DOI: 10.1371/journal.pone.0008260.
1.1.
2008
Rull, K.; Nagirnaja, L.; Ulander, V.-M.; Kelgo, P.; Margus, T.; Kaare, M.; Aittomäki, K.; Laan, M. (2008). Chorionic Gonadotropin Beta gene variants are associated with recurrent miscarriage in two European populations. Journal of Clinical Endocrinology and Metabolism, 93 (12), 4697−4706. DOI: 10.1210/jc.2008-1101.
1.1.
2007
Margus, T.; Remm, M.; Tenson, T. (2007). Phylogenetic distribution of translational GTPases in bacteria. BMC Genomics, 8, 15. DOI: 10.1186/1471-2164-8-15.
1.1.
2005
Hallast, P.; Nagirnaja, L.; Margus, T.; Laan, M. (2005). Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin beta gene cluster. Genome Research, 15 (11), 1535−1546.
1.1.
1998
Liiv, A.; Tenson, T.; Margus, T.; Remme, J. (1998). Multiple functions of the transcribed spacers in ribosomal RNA operons. Biological Chemistry, 379 (7), 783−793.
1.1.
1993
Lewicki, BTU.; Margus, T.; Remme, J.; Nierhaus, KH. (1993). Coupling of ribosomal-RNA transcription and ribosomal assembly invivo - formation of active ribosomal-subunits in escherichia-coli requires transcription of ribosomal-RNA genes by host RNA- polymerase which cannot be replaced by bacteriophage-t7 RNA- polyme. Journal of Molecular Biology, 231 (3), 581−593.
1.1.
1989
Remme, J.; Margus, T.; Villems, R.; Nierhaus, KH. (1989). The 3rd ribosomal transfer RNA- binding site, the e-site, is occupied in native polysomes. European Journal of Biochemistry, 183 (2), 281−284.
23.08.2019

Tõnu Margus

https://www.etis.ee/CV/Tõnu_Margus/eng
tmargus@ebc.ee

Career

Institutions and positions
01.02.2014–31.01.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Research Fellow in Bioinformatics (1,00)
01.09.2007–31.05.2008   
Estonian Biocentre, Specialist (0,20)
01.05.2005–31.12.2007   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Specialist (0,50)
01.05.2005–31.08.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Specialist (0,50)
1997–2007   
Estonian Biocentre, bioinformatics specialis (0,20)
 
 
Education
2007–2013   
PhD student gene technology/bioinformatics
1981–1986   
University of Tartu Faculty of Biology and Geography

Qualifications

Academic degrees
Tõnu Margus, Doctor's Degree, 2013, (sup) Tanel Tenson; Maido Remm, Distribution and phylogeny of the bacterial translational GTPases and the Mqsr/YgiT regulatory system, University of Tartu.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS CLASSIFICATION: B110 Bioinformatics, medical informatics, biomathematics, biometrics
 
 

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2014
Huik, K.; Avi, R.; Uibopuu, H.; Pauskar, M.; Margus, T.; Karki, T.; Krispin, T.; Kool, P.; Rüütel, K.; Talu, A.; Abel-Ollo, K.; Uusküla, A.; Carrillo, AQ.; He, W.; Ahuja, SK.; Lutsar, I. (2014). Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population. Jaids-Journal of Acquired Immune Deficiency Syndromes, 66 (3), 239−244. DOI: 10.1097/QAI.0000000000000127.
1.1.
2013
Rull, Kristiina; Christiansen, Ole Bjarne; Nagirnaja, Liina; Steffensen, Rudi; Margus, Tõnu; Laan, Maris (2013). A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage. Fertility and Sterility, 99 (7), 1930−1936. DOI: 10.1016/j.fertnstert.2013.02.019.
1.1.
2013
Keis, M; Remm, J; Ho, SYW; Davison, J; Tammeleht, E; Tumanov, IL; Saveljev, AP; Männil, P; Kojola, I; Abramov, AV; Margus, T; Saarma, U. (2013). Complete mitochondrial genomes and a novel spatial genetic method reveal cryptic phylogeographic structure and migration patterns among brown bears in north-western Eurasia. Journal of Biogeography, 40 (5), 915−927.10.1111/jbi.12043.
1.1.
2011
Margus, T.; Remm, M.; Tenson, T. (2011). A Computational Study of Elongation Factor G (EFG) Duplicated Genes: Diverged Nature Underlying the Innovation on the Same Structural Template. PLoS ONE, 6, e22789.
1.1.
2010
Kasari, V.; Kurg, K.; Margus, T.; Tenson, T.; Kaldalu, N. (2010). The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. Journal of Bacteriology, 192 (11), 2908−2919. DOI: 10.1128/JB.01266-09.
1.1.
2009
Loogväli, E-L.; Kivisild, T.; Margus, T.; Villems, R. (2009). Explaining the imperfection of the molecular clock of hominid mitochondria. PLoS ONE, e8260. DOI: 10.1371/journal.pone.0008260.
1.1.
2008
Rull, K.; Nagirnaja, L.; Ulander, V.-M.; Kelgo, P.; Margus, T.; Kaare, M.; Aittomäki, K.; Laan, M. (2008). Chorionic Gonadotropin Beta gene variants are associated with recurrent miscarriage in two European populations. Journal of Clinical Endocrinology and Metabolism, 93 (12), 4697−4706. DOI: 10.1210/jc.2008-1101.
1.1.
2007
Margus, T.; Remm, M.; Tenson, T. (2007). Phylogenetic distribution of translational GTPases in bacteria. BMC Genomics, 8, 15. DOI: 10.1186/1471-2164-8-15.
1.1.
2005
Hallast, P.; Nagirnaja, L.; Margus, T.; Laan, M. (2005). Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin beta gene cluster. Genome Research, 15 (11), 1535−1546.
1.1.
1998
Liiv, A.; Tenson, T.; Margus, T.; Remme, J. (1998). Multiple functions of the transcribed spacers in ribosomal RNA operons. Biological Chemistry, 379 (7), 783−793.
1.1.
1993
Lewicki, BTU.; Margus, T.; Remme, J.; Nierhaus, KH. (1993). Coupling of ribosomal-RNA transcription and ribosomal assembly invivo - formation of active ribosomal-subunits in escherichia-coli requires transcription of ribosomal-RNA genes by host RNA- polymerase which cannot be replaced by bacteriophage-t7 RNA- polyme. Journal of Molecular Biology, 231 (3), 581−593.
1.1.
1989
Remme, J.; Margus, T.; Villems, R.; Nierhaus, KH. (1989). The 3rd ribosomal transfer RNA- binding site, the e-site, is occupied in native polysomes. European Journal of Biochemistry, 183 (2), 281−284.
23.08.2019