See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Heiki Vija

https://www.etis.ee/CV/Heiki_Vija/est
11.10.1956
6398 364
heiki.vija@kbfi.ee

Teenistuskäik

Töökohad ja ametid
1996–...   
Keemilise ja Bioloogilise Füüsika Instituut, Teadur (1,00)
01.01.1988–31.12.2006   
Kemotex Bio, insener
01.01.1986–31.12.1996   
KBFI, insener
01.01.1984–31.12.1988   
KI Katsetehas, katsetootja
01.01.1980–31.12.1984   
KETUL, teadur
 
 
Haridustee
2008–2008   
Tallinna Tehnikaülikool magistriõpe
2002–2002   
SWEDAC assessori koolitus laborite akrediteerimiseks
1984–1984   
Kromatograafiliste määramismeetodite ekspertiisi kursus Üleliidulise Kohtuekspertiisi Teadusliku Uurimise Instituudi juures
1982–1982   
Naftasaaduste ja kütte- määrdeanete kriminalistilise ekspertiisi kursus Üleliidulise Kohtuekspertiisi Teadusliku Uurimise Instituudi juures
1975–1980   
Tartu Ülikool, analüütiline keemia

Kvalifikatsioon

Teaduskraadid
Heiki Vija, magistrikraad (teaduskraad), 2008, (juh) Jüri Siigur; Aivar Lõokene, Toksiliste peptiidide eraldamine rohelisest (Amanita phalloides) ja valgest (Amanita virosa) kärbseseenest, Tallinna Tehnikaülikool, Keemia ja materjalitehnoloogia teaduskond, Keemia-ja materjalitehnoloogia teaduskonna dekanaat.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.9. Keskkonnaohtlikke aineid käsitlevad uuringud; CERCS KLASSIFIKAATOR: P305 Keskkonnakeemia ; TÄPSUSTUS: HPLC, UPLC, FPLC kromatograafia, Massspektromeetria,Fluorimeetria,Röntgenfluoressents, Peptiidsüntees ja keemiline süntees.
 
 
Lisainfo
Kromatograafiliste ja keemiliste meetodite erialaassessor Eesti Akrediteerimiskeskuse juures

Jooksvad projektid

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2021
Klepinina, Ljudmila; Klepinin, Aleksandr; Truu, Laura; Chekulayev, Vladimir; Vija, Heiki; Kuus, Kaisa; Teino, Indrek; Pook, Martin; Maimets, Toivo; Kaambre, Tuuli (2021). Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS ONE, 16 (1), e0245348. DOI: 10.1371/journal.pone.0245348.
1.1.
2021
Jemec Kokalj, Anita; Dolar, Andraz; Titova, Jelizaveta; Visnapuu, Meeri; Škrlep, Luka; Drobne, Damjana; Vija, Heiki; Kisand, Vambola; Heinlaan, Margit (2021). Long term exposure to virgin and recycled LDPE microplastics induced minor effects in the freshwater and terrestrial crustaceans Daphnia magna and Porcellio scaber. Polymers, 13 (5). DOI: 10.3390/polym13050771.
1.1.
2020
Kubo, Anna-Liisa; Vasiliev, Grigory; Vija, Heiki; Krištal, Jekaterina; Tõugu, Vello; Visnapuu, Meeri; Kisand, Vambola; Kahru, Anne; Bondarenko, Olesja (2020). Surface carboxylation or PEGylation decreases CuO nanoparticles’ cytotoxicity to human cells in vitro without compromising their antibacterial properties. Archives of Toxicology.
1.1.
2020
Heinlaan, M.; Kasemets, K.; Aruoja, V.; Blinova, I.; Bondarenko, O.; Lukjanova, A.; Khosrovyan, A.; Kurvet, I.; Pullerits, M.; Sihtmäe, M.; Vasiliev, G.; Vija, H.; Kahru, A. (2020). Hazard evaluation of polystyrene nanoplastic with nine bioassays did not show particle-specific acute toxicity. The Science of The Total Environment, 707. DOI: 10.1016/j.scitotenv.2019.136073.
1.1.
2020
Rosenberg, M.; Visnapuu, M.; Vija, H.; Kisand, V.; Kasemets, K.; Kahru, A.; Ivask, A. (2020). Selective antibiofilm properties and biocompatibility of nano-ZnO and nano-ZnO/Ag coated surfaces. Scientific Reports, 10 (1). DOI: 10.1038/s41598-020-70169-w.
6.6.
2020
Rosenberg, M.; Visnapuu, M.; Vija, H.; Kisand, V.; Kasemets, K.; Kahru, A.; Ivask, A. (2020). Selective antibiofilm properties and biocompatibility of nano-ZnO and nano-ZnO/Ag coated surfaces. bioRxiv. DOI: 10.1101/2020.03.18.996967.
1.1.
2019
Kasemets, K., Käosaar, S., Vija, H., Fascio, U., Mantecca, P. (2019). Toxicity of differently sized and charged silver nanoparticles to yeast Saccharomyces cerevisiae BY4741: a nano-bio interaction perspective. Nanotoxicology, 13, 8, 1041−1059. DOI: 10.1080/17435390.2019.1621401.
5.2.
2019
Heinlaan, Margit; Aruoja, Villem; Blinova, Irina; Bondarenko, Olesja; Lukjanova, Aljona; Kasemets, Kaja; Khosrovyan, Alla; Kurvet, Imbi; Pullerits, Mirjam; Sihtmäe, Mariliis; Vasiliev, Grigory; Vija, Heiki; Kahru, Anne (2019). Acute toxicity evaluation of polystyrene nanoplastics with ten different bioassays. Abstracts_Meeting_48: SETAC Europe 29th Annual Meeting, Helsingi, 26-30 May, 2019. SETAC, 254.
5.2.
2019
Visnapuu, Triinu; Ernits, Karin; Vija, Heiki; Bondarenko, Olesja; Adamberg, Signe; Aasamets, Anneli; Adamberg, Kaarel; Alamäe, Tiina (2019). Levan as a versatile biopolymer for coating metal nanoparticles and functionalizing food. 1st Meeting COST ACTION 18132, Functional glyconanomaterials for the development of diagnostics and targeted therapeutic probes, Caparica, Portugal, 18-20.11. Universidade Nova de Lisboa, 35.
1.1.
2018
Ivask, Angela; Pilkington, Emily, H.; Blin, Thomas; Kakinen, Aleksandr; Vija, Heiki; Visnapuu, Meeri; Quinn, John, F.; Whittaker, Michael, R.; Qiao, Ruirui; Davis, THomas, P.; Ke, Pu-Chun; Voelcker, Nicolas, H. (2018). Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an in vitro blood brain barrier model. Biomaterials Science, 6, 314−323. DOI: 10.1039/C7BM01012E.
1.1.
2018
Visnapuu, Meeri; Rosenberg, Merilin; Truska, Egle; Nõmmiste, Ergo; Šutka, Andris; Kahru, Anne; Rähn, Mihkel; Vija, Heiki; Orupõld, Kaja; Kisand, Vambola; Ivask, Angela (2018). UVA-induced antimicrobial activity of ZnO/Ag nanocomposite covered surfaces. Colloids and Surfaces B Biointerfaces, 169, 222−232. DOI: 10.1016/j.colsurfb.2018.05.009.
1.1.
2018
Blinova,I.; Lukjanova,A.; Muna,M.; Vija,H. and Kahru,A. (2018). Evaluation of the potential hazard of lanthanides to freshwater microcrustaceans. The Science of The Total Environment, 642, 1100−1107. DOI: 10.1016/j.scitotenv.2018.06.155.
1.1.
2018
Rosenberg, Merilin; Vija, Heiki; Kahru, Anne; Keevil, C. William; Ivask, Angela (2018). Rapid in situ assessment of Cu-ion mediated effects and antibacterial efficacy of copper surfaces. Scientific Reports, 8 (8172 ), 1−12. DOI: 10.1038/s41598-018-26391-8.
1.1.
2018
Blinova, Irina; Vija, Heiki; Lukjanova, Aljona; Muna, Marge; Syvertsen-Wiig, Guttorm; Kahru, Anne (2018). Assessment of the hazard of nine (doped) lanthanides-based ceramic oxides to four aquatic species. The Science of The Total Environment, 612, 1171−1176. DOI: 10.1016/j.scitotenv.2017.08.274.
1.1.
2018
Kubo, Anna-Liisa; Capjak, Ivona; VinkovićVrček, Ivana; Bondarenko, Olesja, M.; Kurvet, Imbi; Vija, Heiki; Ivask, Angela; Kasemets, Kaja; Kahru, Anne (2018). Antimicrobial potency of differently coated 10 and 50 nm silver nanoparticles against clinically relevant bacteria Escherichia coli and Staphylococcus aureus. Colloids and Surfaces B Biointerfaces, 170, 401−410. DOI: 10.1016/j.colsurfb.2018.06.027.
5.1.
2018
Ounpuu, Ljudmila; Klepinin, Aleksandr; Niemeister, Elen; Vija, Heiki; Kaambre, Tuuli; (2018). The phosphotransfer network and metabolic plasticity of colon cancer cells. P7 b/12−P7 b/12.
5.2.
2018
Muna, M.; Lukjanova, A.; Vija, H.; Kahru, A.; Blinova, I. (2018). Toxicity of lanthanides to freshwater microcrustaceans. SETAC Europe 28th Annual Meeting 13th–17th May 2018. Rome, Italy: Society of Environmental Toxicology and Chemistry Europe (SETAC Europe), 327−327.
1.1.
2017
Mardo, Karin; Visnapuu, Triinu; Vija, Heiki; Aasamets, Anneli; Viigand, Katrin; Alamäe, Tiina (2017). A Highly Active Endo-Levanase BT1760 of a Dominant Mammalian Gut Commensal Bacteroides thetaiotaomicron Cleaves Not Only Various Bacterial Levans, but Also Levan of Timothy Grass. PLoS ONE, 12 (1), e0169989−e0169989. DOI: 10.1371/journal.pone.0169989.
1.1.
2017
Kurvet, I.; Juganson, K.; Vija, H.; Sihtmäe, M.; Blinova, I.; Syvertsen-Wiig, G.; Kahru, A. (2017). Toxicity of Nine (Doped) Rare Earth Metal Oxides and Respective Individual Metals to Aquatic Microorganisms Vibrio fischeri and Tetrahymena thermophila. Materials, 10 (7), 754. DOI: 10.3390/ma10070754.
1.1.
2017
Muna, Marge; Heinlaan, Margit; Blinova, Irina; Vija, Heiki; Kahru, Anne (2017). Evaluation of the effect of test medium on total Cu body burden of nano CuO-exposed Daphnia magna: A TXRF spectroscopy study. Environmental Pollution, 231, 1488−1496. DOI: 10.1016/j.envpol.2017.07.083.
1.1.
2017
Joonas, Elise; Aruoja, Villem; Olli, Kalle; Syvertsen-Wiig, Guttom; Vija, Heiki; Kahru, Anne (2017). Potency of (doped) rare earth oxide particles and their constituent metals to inhibit algal growth and induce direct toxic effects. The Science of The Total Environment, 593-504, 478−486. DOI: 10.1016/j.scitotenv.2017.03.184.
5.2.
2017
Muna, Marge; Heinlaan, Margit; Blinova, Irina; Vija, Heiki; Kahru, Anne (2017). Effect of test media on the toxicity of nano CuO, ZnO and Ag to Daphnia magna and total Cu body burden. ABSTRACT BOOK: Final conference of the COST Action ES1205 Engineered Nanomaterials from Wastewater Treatment & Stormwater to Rivers 7 – 8 February 2017 University of Aveiro. Aveiro, Portugal: COST Action ES1205, 188−190.
1.1.
2016
Bondarenko, Olesja M; Ivask, Angela; Kahru, Anne; Vija, Heiki; Titma, Tiina; Visnapuu, Meeri; Joost, Urmas; Pudova, Ksenia; Adamberg, Signe; Visnapuu, Triinu; Alamäe, Tiina. (2016). Bacterial polysaccharide levan as stabilizing, non-toxic and functional coating material for microelement-nanoparticles. Carbohydrate Polymers, 136, 710−720. DOI: 10.1016/j.carbpol.2015.09.093.
5.1.
2016
Juganson, Katre; Blinova, Irina; Vija, Heiki; Kahru, Anne (2016). The effects of rare earth composite oxide mesoparticles and their ionic constituents to the ciliated protozoan Tetrahymena thermophila. Toxicology Letters, 258. Elsevier, S149.
5.1.
2016
Mardo, Karin; Visnapuu, Triinu; Aasamets, Anneli; Viigand, Katrin; Bondarenko, Olesja; Vija, Heiki; Adamberg Kaarel; Adamberg, Signe; Alamäe, Tiina. (2016). Enzymatic synthesis and ways of further treatment of fructooligosaccharides and polymeric levan for prebiotic efficiency studies. New Biotechnology, 33: 17th European Congress on Biotechnology; Krakov, Poland; 3-6.07.2016. ELSEVIER, S122−123. DOI: 10.1016/j.nbt.2016.06.1148.
5.2.
2016
Blinova, I.; Vija, H.; Kurvet, I.; Kahru, A. (2016). Ecotoxicological evaluation of technology-critical elements. Book of Abstracts: Interfaces Against Pollution, Environmental Challenges & Opportunities: Interfaces Against Pollution (IAP2016), Lleida, Spain, 4.-7. september 2016. Spain: Universitat de Lleida, 129.
5.2.
2016
Kahru, A.; Blinova, I.; Kurvet, I.; Juganson, K.; Vija, H.; Joonas, E. and Syvertsen-Wiig, G. (2016). Effects of (doped) rare earth oxides on algae, bacteria, protozoa and crustaceans. Book of Abstracts: Interfaces Against Pollution, Environmental Challenges & Opportunities: Interfaces Against Pollution (IAP2016), Lleida, Spain, 4.-7. september 2016. Spain: Universitat de Lleida, 160.
5.2.
2016
Muna, M.; Heinlaan, M.; Blinova, I.; Vija, H.; Kahru, A. (2016). Exposure of Freshwater Zooplankton to Copper Nanoparticles: Toxicity and Copper Body Burden. Book of Abstracts: EcoBalt 2016. Tartu: EcoBalt2016, 33.
5.2.
2016
Mardo, K.; Visnapuu, T.; Aasamets, A.; Kõrgesaar, K; Vija, H.; Alamäe, T. (2016). NOVEL PREBIOTIC FRUCTOOLIGOSACCHARIDES PREPARED BY ENZYMATIC SYNTHESIS AND DEGRADATION OF LEVAN. In: 3rd Congress of Baltic Microbiologists, Vilnius, 18-21 October 2016. 3rd Congress of Baltic Microbiologists, Vilnius, 18-21 October 2016.
5.2.
2016
Heinlaan, M.; Muna, M.; Vija, H.; Blinova, H.; Kahru, A. (2016). At Equitoxic Concentrations, CuO Nanoparticles Lead to Higher Copper Body Burden in Daphnia magna Compared to Soluble Cu-salt. Abstract Book of 8th Int Nanotoxicology Congress: 8th Int Nanotoxicology Congress, June 1-4, Boston, USA. Boston, USA: 8th Int Nanotoxicology Congress, June 1-4, Boston, USA, 122−122.
5.2.
2016
Heinlaan, Margit; Muna, Marge; Vija, Heiki; Slaveykova, Vera; Kahru, Anne (2016). Exposure to sublethal concentrations of metal nanoparticles may lead to disturbed feeding behavior and elevated metal body burden of Daphnia magna. Abstract Book: SETAC Europe 2016, Nantes, France 22-26.05.2016. Setac, TU037−TU037.
1.1.
2015
Ivask, A.; Titma, T.; Visnapuu, M.; Vija, H.; Kakinen, A.; Sihtmae, M.; Pokhel, S.; Madler, L.; Heinlaan, M.; Kisand, V.; Shimmo, R.; Kahru, A. (2015). Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In Vitro. Current Topics in Medicinal Chemistry, 15 (18), 1914−1929. DOI: doi.org/10.2174/1568026615666150506150109.
3.2.
2015
Jõgi, E; Metsla, K; Visnapuu, T; Aasamets, A; Vija, H; Alamäe, T. (2015). Synthesis and purification of functional fructans. Proceedings of the 11th International Conference on Polysaccharides-Glycoscience.: 11th International Conference on Polysaccharides-Glycoscience, 7-9 October, Prague, Czeck Republic. Ed. Rapkova, R; Copikova, J; Šarka, E. Czech Chemical Society, 5−9.
5.2.
2015
Visnapuu, T; Aasamets, A; Jõgi, E; Metsla, K; Vija, H; Adamberg, S; Alamäe, T. (2015). Levansucrase Lsc3 as a feasible catalyst for the synthesis of novel prebiotics. The 4th Beneficial Microbes Conference 16-18 March 2015, the Netherlands.
5.2.
2015
Jõgi, Erik; Viigand, Katrin; Metsla, Kati; Visnapuu, Triinu; Vija, Heiki; Alamäe, Tiina (2015). Yeast-aided Purification of Levansucrase-produced Prebiotic Fructooligosaccharides. 32nd International Specialized Symposium on Yeasts, 13-17 September 2015, Perugia, Italy.
5.2.
2015
Kahru, A.; Aruoja, V.; Ivask, A.; Pokhrel, S.; Madler, L.; Sihtmäe, M.; Käkinen, A.; Vija, H. (2015). Toxicity of 11 Metal Oxide Nanoparticles: FP7 project MODERN. Book of Abstracts, CompNanoTox, European Conference on Computational Nanotoxicology, 4-6 November 2015, Malaga, Spain: European Conference on Computational Nanotoxicology, Malaga, Spain, 4-6 November 2015. , 63−63.
1.1.
2014
Mardo, Karin; Visnapuu, Triinu; Gromkova, Maria; Aasamets, Anneli; Viigand, Katrin; Vija, Heiki; Alamäe, Tiina. (2014). High-Throughput Assay of Levansucrase Variants in Search of Feasible Catalysts for the Synthesis of Fructooligosaccharides and Levan. Molecules, 19 (6), 8434−8455. DOI: 10.3390/molecules19068434.
1.1.
2014
Ivask, A.; Kurvet, I.; Kasemets, K.; Blinova, I.; Aruoja, V.; Suppi, S.; Vija, H.; Käkinen, A.; Titma, T.; Heinlaan, M.; Visnapuu, M.; Koller, D.; Kisand, V.; Kahru, A. (2014). Size-dependent Toxicity of Silver Nanoparticles to Bacteria, Yeast, Algae, Crustaceans and Mammalian Cells in Vitro. PLoS ONE, 9 (7), e102108.
1.1.
2014
Mardo, Karin; Visnapuu, Triinu; Vija, Heiki; Elmi, Triin; Alamäe, Tiina (2014). Mutational analysis of conserved regions harbouring catalytic triad residues of the levansucrase protein encoded by lsc-3 (lsc3) gene of Pseudomonas syringae pv. tomato DC3000. Biotechnology and Applied Biochemistry, 61 (1), 11−22. DOI: 10.1002/bab.1129.
1.1.
2014
Adamberg, Signe; Tomson, Katrin; Vija, Heiki; Puurand, Marju; Kabanova, Natalja; Visnapuu, Triinu; Jõgi, Eerik; Alamäe, Tiina; Adamberg, Kaarel (2014). Degradation of fructans and production of propionic acid by Bacteroides thetaiotaomicron are enhanced by the shortage of amino acids. Frontiers in Nutrition, 1 (21), 1−10. DOI: 10.3389/fnut.2014.00021.
3.1.
2014
Aasamets, Anneli; Visnapuu, Triinu; Vija, Heiki; Jõgi, Eerik; Alamäe, Tiina (2014). Production of levan and fructooligosaccharides using levansucrase of Pseudomonas syringae pv. tomato. Proceedings of the 10th International Conference on Polysaccharides-Glycoscience: 10th International Conference on Polysaccharides-Glycoscience. Ed. Copikova, J; Šarka, E. Prague, Czech Republic: Czech Chemical Society, 12−16.
3.4.
2014
Adamberg, S.; Tomson, K.; Vija, H.; Visnapuu, T.; Adamberg, K. (2014). Co-metabolism of amino acids and polyfructans by Bacteroides thetaiotaomicron in defined media. ENGIHR Conference, Karlsruhe, 24-26. September 2014; http://www.engihr.eu/2014-engihr-conference/.
5.1.
2014
Aruoja, V.; Pokhrel, S.; Sihtmäe, M.; Vija, H.; Kahru, A. (2014). Mechanisms behind toxicity of 11 metal oxide nanoparticles to alga Pseudokirchneriella subcapitata. Toxicology Letters, 229 (229), S187−S187.
5.1.
2014
Visnapuu, Triinu; Aasamets, Anneli; Mardo, Karin; Jõgi, Eerik; Vija, Heiki; Alamäe, Tiina (2014). Synthesis of potential prebiotics using Pseudomonas syringae DC3000 levansucrase Lsc3. New Biotechnology, 31: 16th European Congress on Biotechnology, Edinburgh (UK) 13-16.07.2014. , S17. DOI: 10.1016/j.nbt.2014.05.1652.
5.2.
2014
Ivask, Angela; Visnapuu, Triinu; Bondarenko, Olesja; Vija, Heiki; Titma, Tiina; Alamäe, Tiina (2014). Functional Food Ingredients: synthesis and characterization of nanoparticles coated with levan from Pseudomonas syringae DC3000 and evaluation of their in vitro effects on bacteria and mammalian cells. Book of abstracts: 2nd Congress of Baltic Microbiologists, Tartu.
5.2.
2014
Jõgi, Eerik; Visnapuu, Triinu; Vija, Heiki; Alamäe, Tiina (2014). The production of fructooligosaccharides with P. syringae pv. tomato DC3000 levansucrase Lsc3 and purification of polymerization products. International Scientific Conference on Probiotics and Prebiotics (IPC2014); Budapest, Hungary; 24-26.06.2014.
5.2.
2014
Aasamets, Anneli; Visnapuu, Triinu; Vija, Heiki; Jõgi, Eerik; Alamäe, Tiina (2014). Optimization of reaction conditions for cost-efficient production of levan and fructooligosaccharides using levansucrase of Pseudomonas syringae DC3000. 2nd Congress of Baltic Microbiologists, Tartu, Estonia, 16.-19.10.
5.2.
2014
Adamberg, S.; Tomson, K.; Vija, H.; Puurand, M.; Adamberg, K. (2014). Functional Food Ingredients: metabolism of fructans by Bacteroides thetaiotaomicron and colon microbiota studied by isothermal microcalorimetry. Second Congress of Baltic Microbiologists, Tartu, 17 - 18 October, 2014.
1.1.
2013
Samel, Mari; Vija, Heiki; Kurvet, Imbi; Künnis-Beres, Kai; Trummal, Katrin; Subbi, Juhan; Kahru, Anne; Siigur, Jüri (2013). Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells. Toxins, 5, 203−223. DOI: 10.3390/toxins5020203.
3.4.
2013
Adamberg, S.; Tomson, K.; Vija, H.; Wadström, T.; Ljungh, Å.; Adamberg, K. (2013). Can isothermal microcalorimetry be used to characterise bacterial growth on prebiotic oligosaccharides? ENGIHR Conference, Valencia (Spain), 18-20 September 2013.
5.1.
2013
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Samel, Mari; Vija, Heiki; Siigur, Jüri (2013). Vipera lebetina (snake) venom components affecting hemostasis. Journal of Thrombosis and Haemostasis, 11 (Supplement 2), 893−893.
5.2.
2013
Visnapuu, Triinu; Mardo, Karin; Vija, Heiki; Mäe, Andres (2013). Mutational analysis of conserved regions of the levansucrase Lsc3 from Pseudomonas syringae DC3000. EuroCarb17. 17th European Carbohydrate Symposium, Tel-Aviv, Israel, 7.-11.07..
5.2.
2012
Kahru, A.; Mortimer, M.; Blinova, I.; Bondarenko, O.; Kurvet, I.; Ivask, A.; Vija, H.; Käkinen, A.; Kanarbik, L.; Juganson, K.; Aruoja, V.; Sihtmäe, M.; Künnis, K. (2012). Comparative study of physico-chemical properties and biological effects of silver and silica nanoparticles to bacteria and environmentally relevant non-vertebrate species. Nordic environmental chemistry conference (NECC 2012). Harjattula Manor on Kakskerta, Åbo/Turku, Finland on June 4-7, 2012..
1.1.
2011
Siigur, Ene; Tõnismägi, Külli; Trummal, Katrin; Samel, Mari; Vija, Heiki; Aaspõllu, Anu; Rönnholm, Gunilla; Subbi, Juhan; Kalkkinen, Nisse; Siigur, Jüri. (2011). A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie, 93, 321−330.10.1016/j.biochi.2010.10.004.
5.1.
2011
Siigur, Ene; Trummal, Katrin; Samel, Mari; Tonismagi, Kylli; Vija, Heiki; Subbi, Juhan; Siigur, Juri (2011). Multifunctional metalloproteinase from Vipera Lebetina venom. Journal of Thrombosis and Haemostasis, Volume 9: XXIII Congress of the International Society on Thrombosis and Haemostasis. Ed. Greaves, Mike; Lane, David; Ozaki, Yukio;. Kyoto: Wiley-Blackwell,. (Supplement; 2).
5.2.
2011
Käkinen, Aleksandr; Vija, Heiki; Bondarenko, Olesja; Juganson, Katre; Blinova, Irina; Kahru, Anne. (2011). Physico-chemical Characterisation of Silver and Copper Nanoparticles for Ecotoxicological Studies. Book of Abstracts: 14th IUPAC International Symposium on Macro Molecular Complexes, MMC-14, Helsinki, Soome 14-17.08.2011. , 201−201.
5.2.
2011
Samel, Mari; Vija, Heiki ; Kurvet, Imbi; Subbi, Juhan; Kahru, Anne; Siigur, Jüri. (2011). Antiplatelet, antibacterial and anticancer effect of PLA2-S from Vipera lebetina, Vipera berus berus and Naja naja oxiana venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 160−160.
1.1.
2010
Pochard, I.; Labbez, C.; Nonat, A.; Vija, H.; Jönsson, B. (2010). The effect of polycations on early cement paste. Cement and Concrete Research, 40, 1488−1494.
1.1.
2010
Sepp, Mervi; Vendelin, Marko; Vija, Heiki; Birkedal, Rikke (2010). ADP Compartmentation analysis reveals coupling between pyruvate kinase and ATPases in heart muscle. Biophysical Journal, 98 (12), 2785−2793.10.1016/j.bpj.2010.03.025.
1.1.
2010
Siigur, Jüri; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Rönnholm, Gunilla; Kalkkinen, Nisse; Siigur, Ene. (2010). Separation and analysis of peptides and proteins from Vipera lebetina snake venom. Procedia Chemistry, 2, 109−115.
5.1.
2010
Siigur, Jüri; Trummal, Katrin; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Siigur, Ene; Subbi, Juhan. (2010). Specificity Studies of Proteinases from Vipera lebetina Snake Venom. Journal of Thrombosis and Haemostasis, 8 (Supplement s1), 54−54.
5.1.
2010
Sepp, Mervi; Vendelin, Marko; Vija, Heiki; Birkedal, Rikke (2010). Analysis of intracellular ADP compartmentation reveals functional coupling between pyruvate kinase and ATPases in rat cardiomyocytes. Biophysical Journal, 98, 734a. DOI: 10.1016/j.bpj.2009.12.4027.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri. (2009). Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A2 from the snake venom of Vipera lebetina (Levantine viper). Toxicon, 54 (4), 429−439. DOI: 10.1016/j.toxicon.2009.05.010.
1.1.
2009
Paalme, Viiu; Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Järvekülg, Lilian; Vija, Heiki; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2009). Nerve growth factor from Vipera lebetina venom. Toxicon, 54 (3), 329−336. DOI: 10.1016/j.toxicon.2009.05.001.
1.1.
2009
Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Tõnismägi, Külli; Trummal, Katrin; Subbi, Juhan; Siigur, Jüri (2009). VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom Purification and cDNA cloning. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 153, 253−260. DOI: 10.1016/j.cbpb.2009.03.002.
1.1.
2009
Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu; Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.
1.1.
2009
Vija, Heiki; Kesvatera, Tõnu (2009). The effect of solvent composition on complex formation of S100B protein with peptides. Proceedings of the Estonian Academy of Sciences, 58 (1), 67−72.
5.1.
2009
Siigur, Ene; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri (2009). Haemostasis affecting proteases from Vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 7, PP-MO-149−PP-MO-149.
5.2.
2009
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan;Siigur, Ene (2009). Acidic Platelet Aggregation Inhibiting Phospholipas A2s from the Snake Venom of Vipera lebetina (Levantine viper). EFATH 2009: 4th International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis, Boston Massachusetts USA, 17-19 July. Boston, Massachusetts, 20.
5.2.
2009
Siigur, J; Vija, H; Samel, M; Tõnismägi, K; Trummal, K; Aaspõllu, A; Subbi, J; Rönnholm, G; Kalkkinen, N; Siigur, E. (2009). Separation and Analysis of Peptides and Proteins from Vipera Lebetina Snake Venom. NoSSS2009 5thConference on Separation and Related Techniques by Nordic Separation Science Society, Tallinn Universityof Technology, 26-29 August 2009. Tallinna Tehnikaülikooli Kirjastus, 133−133.
1.1.
2008
Samel, M.; Tõnismägi, K.; Rönnholm, G.; Vija, H.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2008). L-Amino acid oxidase from Naja naja oxiana venom. Comparative Biochemistry and Physiology, 149 (4), 572−580. DOI: 10.1016/j.cbpb.2007.11.008.
5.2.
2008
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Subbi, Juhan; Siigur, Ene (2008). Acidic platelet aggregation inhibiting phospholipase A2 from Vipera lebetina snake venom In:16th European Section Meeting of the International Society on Toxinology, Book of abstracts, Leuven,Belgium, 7-10 September 2008 pp.54-55. 16th European Section Meeting of the International Society on Toxinology, Book of abstracts: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 54−55.
1.3.
2007
Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Aaspõllu, Anu; Siigur, Ene; Siigur, Jüri. (2007). Heterodimeric disintegrin and phospholipase A2 from Vipera lebetina snake venom. Latvijas Kimijas Žurnals (Latvian Journal of Chemistry), 3, 291−292.
5.1.
2007
Siigur, Ene; Samel, Mari; Tõnismägi, Külli; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Pikver, Rein; Subbi, Juhan; Siigur, Jüri (2007). Platelet aggregation inhibiting components from vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 5: XXI congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland, 6-12 July 2007. P-S-272−P-S-272. (Supplement 2).
1.1.
2006
Samel, M.; Vija, H.; Rönnholm, G.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2006). Isolation and characterization of an apoptotic and platelet aggragation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom. Biochimica et Biophysica Acta, 1764, 707−714.
5.2.
2006
Siigur, Jüri; Vija, Heiki; Aaspõllu, Anu; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Siigur, Ene. (2006). Heterodimeric Disintegrin VLT-2 from Vipera lebetina Snake Venom. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. 275−275.
1.1.
2005
Siigur, J.; Tonismagi, K.; Trummal, K.; Aaspollu, A; Samel, M; Vija, H; Subbi, J; Kalkkinen, N.; Siigur, E. (2005). Vipera lebetina Venom Contains All Types of Snake Venom Metalloproteases. Pathophysiology of haemostasis and thrombosis., 34, 209−214.
1.1.
2003
Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2003). Metalloproteinase with factor X activating and fibrinogenolytic activities from Vipera berus berus venom. Comparative Biochemistry and Physiology, 135B, 575−582.
1.1.
2003
Vallikivi, I.; Lille, Ü.; Lõokene, A.; Metsala, A.; Sikk, P.; Tõugu, V.; Vija, H.; Villo, L.; Parve, O. (2003). Lipase action on some non-triglyceride substrates. Journal of Molecular Catalysis B: Enzymatic, 22, 279−298. DOI: 10.1016/S1381-1177(03)00043-2.
5.2.
2003
Siigur, Jüri; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Tammiste, Indrek; Siigur, Ene. (2003). HETERODIMERIC DISINTEGRINS IN Vipera lebetina SNAKE VENOM GLANDARE SYNTHESIZED FROM DIFFERENT GENES. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Ed. Julian White and Vaughan Williams. 29−29.
1.1.
2002
Siigur, J.; Trummal, K.; Tõnismägi, K.; Samel, M.; Siigur, E.; Vija, H.; Tammiste, I.; Subbi, J. (2002). Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy, 16, 161−170.
5.2.
2002
Kesvatera, T.; Jönsson, B.; Telling, A.; Tõugu, V.; Vija, H.; Thulin, E.; Linse, S. (2002). pKa Shifts of Ionizable Groups in Folded Apo Calbindin D9k and Their Manifestation in Ca2+ Binding. 1: The Lise Meitner Symposium: Current Progress in Protein Folding and Design, March 26-27, 2002, Lund, Sweden. Lund, Rootsi,.
1.1.
2001
Siigur, E.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2001). Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochimica et Biophysica Acta, 1568 (1), 90−98.
1.1.
2001
Siigur, J.; Aaspõllu, A.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, E. (2001). Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 31 (3), 123−132.
1.1.
2001
Kesvatera, T.; Jönsson, B.; Telling, A.; Tõugu, V.; Vija, H.; Thulin, E.; Linse, S. (2001). Calbindin D9k: A Protein Optimized for Calcium Binding at Neutral pH. Biochemistry, 40 (50), 15334−15340.
1.1.
2001
Seppet, EK.; Kaambre, T.; Sikk, P.; Tiivel, T.; Vija, H.; Tonkonogi, M.; Sahlin, K.; Kay, L.; Appaix, F.; Braun, U.; Eimre, M.; Saks, VA. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1504, 379−395. DOI: 10.1016/S0005-2728(00)00269-3.
1.1.
2000
Trummal, K.; Vija, H.; Subbi, J.; Siigur, J. (2000). MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochimica et Biophysica Acta, 1476 (2), 331−336.
1.1.
1999
Käämbre, T.; Tõugu, V.; Käämbre, P.; Vija, H.; Sikk, P. (1999). Hydrolysis of emulsified mixtures of triacylglycerols by pancreatic lipase. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1431 (1), 97−106. DOI: 10.1016/S0167-4838(99)00047-3.
1.1.
1997
Vija, H.; Telling, A.; Tõugu, V. (1997). Lipase-catalyzed synthesis of iso-amyl acetate in supercritical carbon dioxide and in hexane. Bioorganic & Medicinal Chemistry Letters, 7 (3), 259−262.
1.1.
1997
Parve, O.; Vallikivi, I.; Lahe, L.; Metsala, A.; Lille, U.; Tougu, V.; Vija, H.; Pehk, T (1997). Lipase-catalysed enantioselective hydrolysis of bicyclo[3.2.0]heptanol esters in supercritical carbon dioxide. Bioorganic & Medicinal Chemistry Letters, 7 (7), 811−816.
1.1.
1997
Parve, O.; Vallikivi, I.; Metsala, A.; Lille, Ü.; Tõugu, V.; Sikk, P.; Käämbre, T.; Vija, H.; Pehk, T (1997). Lipase-catalysed enantioselective hydrolysis: Interpretation of the kinetic results in terms of frontier orbital localisation. Tetrahedron, 53 (13), 4889−4900.
3.5.
1996
Lille, Ülo; Metsala, Andrus; Parve, Omar; Tõugu, Vello; Vija, Heiki. (1996). "Lipolase" allub sekundaarsete alkoholide enantioeelistuse üldisele reeglile nii vesi- kui ka superkriitilise (SK)SO2 keskkonnas. XVII Eesti keemiapäevad : teaduskonverentsi ettekannete referaadid = 17th Estonian Chemistry Days : abstracts of scientific conference. Tartu: TTY puuduv kirjastus, 101−102.
1.1.
1989
Pehk, T; Haga, M; Vija, H; Lippmaa, E. (1989). High-fieldD 2D NMR-Spectroscopy of Amanitin isomers. Magnetic Resonance in Chemistry, 27, 173−183.

Tööstusomand

13.03.2021

Heiki Vija

https://www.etis.ee/CV/Heiki_Vija/eng
11.10.1956
6398 364
heiki.vija@kbfi.ee

Career

Institutions and positions
1996–...   
National Institute of Chemical Physics and Biophysics, Researcher (1,00)
01.01.1988–31.12.2006   
engineer, Kemotex Bio
01.01.1986–31.12.1996   
engineer, Department of biochemistry, NICPB
01.01.1984–31.12.1988   
chemist, Pilot Production Factory
01.01.1980–31.12.1984   
research scientist, KETUL
 
 
Education
2008–2008   
Tallinn University of Technology graduate school
2002–2002   
SWEDAC assessor training course for laboratory accreditation
1984–1984   
Cource of expert assessment of chromatographic methods of determination at All-Union Forensic Research Institute
1982–1982   
Cource of expert assessment of oil products, heating fuels and lubricants at All-Union Forensic Research Institute
1975–1980   
Department of Chemistry, Tartu State University, Diploma (M. Sc.)

Qualifications

Academic degrees
Heiki Vija, Research Master's Degree, 2008, (sup) Jüri Siigur; Aivar Lõokene, Toksiliste peptiidide eraldamine rohelisest (Amanita phalloides) ja valgest (Amanita virosa) kärbseseenest (Isolation of toxic peptides from Deathcap (Amanita phalloides) and Destroying Angel (Amanita virosa)), Tallinn University of Technology Faculty of Chemical and Materials Technology, Faculty of Chemical and Materials Technology, Deans Office.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.9. Research into Substances Hazardous to the Environment; CERCS CLASSIFICATION: P305 Environmental chemistry ; SPECIFICATION: HPLC, UPLC, FPLC Chromatography, Massspectrometry, Fluorimetry, X-Ray Fluoressents, Peptide- and chemical synthesis.
 
 
Additional information
Expert of chromatographics and chemicals methods at Estonian Accreditation Centre

Projects in progress

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2021
Klepinina, Ljudmila; Klepinin, Aleksandr; Truu, Laura; Chekulayev, Vladimir; Vija, Heiki; Kuus, Kaisa; Teino, Indrek; Pook, Martin; Maimets, Toivo; Kaambre, Tuuli (2021). Colon cancer cell differentiation by sodium butyrate modulates metabolic plasticity of Caco-2 cells via alteration of phosphotransfer network. PLoS ONE, 16 (1), e0245348. DOI: 10.1371/journal.pone.0245348.
1.1.
2021
Jemec Kokalj, Anita; Dolar, Andraz; Titova, Jelizaveta; Visnapuu, Meeri; Škrlep, Luka; Drobne, Damjana; Vija, Heiki; Kisand, Vambola; Heinlaan, Margit (2021). Long term exposure to virgin and recycled LDPE microplastics induced minor effects in the freshwater and terrestrial crustaceans Daphnia magna and Porcellio scaber. Polymers, 13 (5). DOI: 10.3390/polym13050771.
1.1.
2020
Kubo, Anna-Liisa; Vasiliev, Grigory; Vija, Heiki; Krištal, Jekaterina; Tõugu, Vello; Visnapuu, Meeri; Kisand, Vambola; Kahru, Anne; Bondarenko, Olesja (2020). Surface carboxylation or PEGylation decreases CuO nanoparticles’ cytotoxicity to human cells in vitro without compromising their antibacterial properties. Archives of Toxicology.
1.1.
2020
Heinlaan, M.; Kasemets, K.; Aruoja, V.; Blinova, I.; Bondarenko, O.; Lukjanova, A.; Khosrovyan, A.; Kurvet, I.; Pullerits, M.; Sihtmäe, M.; Vasiliev, G.; Vija, H.; Kahru, A. (2020). Hazard evaluation of polystyrene nanoplastic with nine bioassays did not show particle-specific acute toxicity. The Science of The Total Environment, 707. DOI: 10.1016/j.scitotenv.2019.136073.
1.1.
2020
Rosenberg, M.; Visnapuu, M.; Vija, H.; Kisand, V.; Kasemets, K.; Kahru, A.; Ivask, A. (2020). Selective antibiofilm properties and biocompatibility of nano-ZnO and nano-ZnO/Ag coated surfaces. Scientific Reports, 10 (1). DOI: 10.1038/s41598-020-70169-w.
6.6.
2020
Rosenberg, M.; Visnapuu, M.; Vija, H.; Kisand, V.; Kasemets, K.; Kahru, A.; Ivask, A. (2020). Selective antibiofilm properties and biocompatibility of nano-ZnO and nano-ZnO/Ag coated surfaces. bioRxiv. DOI: 10.1101/2020.03.18.996967.
1.1.
2019
Kasemets, K., Käosaar, S., Vija, H., Fascio, U., Mantecca, P. (2019). Toxicity of differently sized and charged silver nanoparticles to yeast Saccharomyces cerevisiae BY4741: a nano-bio interaction perspective. Nanotoxicology, 13, 8, 1041−1059. DOI: 10.1080/17435390.2019.1621401.
5.2.
2019
Heinlaan, Margit; Aruoja, Villem; Blinova, Irina; Bondarenko, Olesja; Lukjanova, Aljona; Kasemets, Kaja; Khosrovyan, Alla; Kurvet, Imbi; Pullerits, Mirjam; Sihtmäe, Mariliis; Vasiliev, Grigory; Vija, Heiki; Kahru, Anne (2019). Acute toxicity evaluation of polystyrene nanoplastics with ten different bioassays. Abstracts_Meeting_48: SETAC Europe 29th Annual Meeting, Helsingi, 26-30 May, 2019. SETAC, 254.
5.2.
2019
Visnapuu, Triinu; Ernits, Karin; Vija, Heiki; Bondarenko, Olesja; Adamberg, Signe; Aasamets, Anneli; Adamberg, Kaarel; Alamäe, Tiina (2019). Levan as a versatile biopolymer for coating metal nanoparticles and functionalizing food. 1st Meeting COST ACTION 18132, Functional glyconanomaterials for the development of diagnostics and targeted therapeutic probes, Caparica, Portugal, 18-20.11. Universidade Nova de Lisboa, 35.
1.1.
2018
Ivask, Angela; Pilkington, Emily, H.; Blin, Thomas; Kakinen, Aleksandr; Vija, Heiki; Visnapuu, Meeri; Quinn, John, F.; Whittaker, Michael, R.; Qiao, Ruirui; Davis, THomas, P.; Ke, Pu-Chun; Voelcker, Nicolas, H. (2018). Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an in vitro blood brain barrier model. Biomaterials Science, 6, 314−323. DOI: 10.1039/C7BM01012E.
1.1.
2018
Visnapuu, Meeri; Rosenberg, Merilin; Truska, Egle; Nõmmiste, Ergo; Šutka, Andris; Kahru, Anne; Rähn, Mihkel; Vija, Heiki; Orupõld, Kaja; Kisand, Vambola; Ivask, Angela (2018). UVA-induced antimicrobial activity of ZnO/Ag nanocomposite covered surfaces. Colloids and Surfaces B Biointerfaces, 169, 222−232. DOI: 10.1016/j.colsurfb.2018.05.009.
1.1.
2018
Blinova,I.; Lukjanova,A.; Muna,M.; Vija,H. and Kahru,A. (2018). Evaluation of the potential hazard of lanthanides to freshwater microcrustaceans. The Science of The Total Environment, 642, 1100−1107. DOI: 10.1016/j.scitotenv.2018.06.155.
1.1.
2018
Rosenberg, Merilin; Vija, Heiki; Kahru, Anne; Keevil, C. William; Ivask, Angela (2018). Rapid in situ assessment of Cu-ion mediated effects and antibacterial efficacy of copper surfaces. Scientific Reports, 8 (8172 ), 1−12. DOI: 10.1038/s41598-018-26391-8.
1.1.
2018
Blinova, Irina; Vija, Heiki; Lukjanova, Aljona; Muna, Marge; Syvertsen-Wiig, Guttorm; Kahru, Anne (2018). Assessment of the hazard of nine (doped) lanthanides-based ceramic oxides to four aquatic species. The Science of The Total Environment, 612, 1171−1176. DOI: 10.1016/j.scitotenv.2017.08.274.
1.1.
2018
Kubo, Anna-Liisa; Capjak, Ivona; VinkovićVrček, Ivana; Bondarenko, Olesja, M.; Kurvet, Imbi; Vija, Heiki; Ivask, Angela; Kasemets, Kaja; Kahru, Anne (2018). Antimicrobial potency of differently coated 10 and 50 nm silver nanoparticles against clinically relevant bacteria Escherichia coli and Staphylococcus aureus. Colloids and Surfaces B Biointerfaces, 170, 401−410. DOI: 10.1016/j.colsurfb.2018.06.027.
5.1.
2018
Ounpuu, Ljudmila; Klepinin, Aleksandr; Niemeister, Elen; Vija, Heiki; Kaambre, Tuuli; (2018). The phosphotransfer network and metabolic plasticity of colon cancer cells. P7 b/12−P7 b/12.
5.2.
2018
Muna, M.; Lukjanova, A.; Vija, H.; Kahru, A.; Blinova, I. (2018). Toxicity of lanthanides to freshwater microcrustaceans. SETAC Europe 28th Annual Meeting 13th–17th May 2018. Rome, Italy: Society of Environmental Toxicology and Chemistry Europe (SETAC Europe), 327−327.
1.1.
2017
Mardo, Karin; Visnapuu, Triinu; Vija, Heiki; Aasamets, Anneli; Viigand, Katrin; Alamäe, Tiina (2017). A Highly Active Endo-Levanase BT1760 of a Dominant Mammalian Gut Commensal Bacteroides thetaiotaomicron Cleaves Not Only Various Bacterial Levans, but Also Levan of Timothy Grass. PLoS ONE, 12 (1), e0169989−e0169989. DOI: 10.1371/journal.pone.0169989.
1.1.
2017
Kurvet, I.; Juganson, K.; Vija, H.; Sihtmäe, M.; Blinova, I.; Syvertsen-Wiig, G.; Kahru, A. (2017). Toxicity of Nine (Doped) Rare Earth Metal Oxides and Respective Individual Metals to Aquatic Microorganisms Vibrio fischeri and Tetrahymena thermophila. Materials, 10 (7), 754. DOI: 10.3390/ma10070754.
1.1.
2017
Muna, Marge; Heinlaan, Margit; Blinova, Irina; Vija, Heiki; Kahru, Anne (2017). Evaluation of the effect of test medium on total Cu body burden of nano CuO-exposed Daphnia magna: A TXRF spectroscopy study. Environmental Pollution, 231, 1488−1496. DOI: 10.1016/j.envpol.2017.07.083.
1.1.
2017
Joonas, Elise; Aruoja, Villem; Olli, Kalle; Syvertsen-Wiig, Guttom; Vija, Heiki; Kahru, Anne (2017). Potency of (doped) rare earth oxide particles and their constituent metals to inhibit algal growth and induce direct toxic effects. The Science of The Total Environment, 593-504, 478−486. DOI: 10.1016/j.scitotenv.2017.03.184.
5.2.
2017
Muna, Marge; Heinlaan, Margit; Blinova, Irina; Vija, Heiki; Kahru, Anne (2017). Effect of test media on the toxicity of nano CuO, ZnO and Ag to Daphnia magna and total Cu body burden. ABSTRACT BOOK: Final conference of the COST Action ES1205 Engineered Nanomaterials from Wastewater Treatment & Stormwater to Rivers 7 – 8 February 2017 University of Aveiro. Aveiro, Portugal: COST Action ES1205, 188−190.
1.1.
2016
Bondarenko, Olesja M; Ivask, Angela; Kahru, Anne; Vija, Heiki; Titma, Tiina; Visnapuu, Meeri; Joost, Urmas; Pudova, Ksenia; Adamberg, Signe; Visnapuu, Triinu; Alamäe, Tiina. (2016). Bacterial polysaccharide levan as stabilizing, non-toxic and functional coating material for microelement-nanoparticles. Carbohydrate Polymers, 136, 710−720. DOI: 10.1016/j.carbpol.2015.09.093.
5.1.
2016
Juganson, Katre; Blinova, Irina; Vija, Heiki; Kahru, Anne (2016). The effects of rare earth composite oxide mesoparticles and their ionic constituents to the ciliated protozoan Tetrahymena thermophila. Toxicology Letters, 258. Elsevier, S149.
5.1.
2016
Mardo, Karin; Visnapuu, Triinu; Aasamets, Anneli; Viigand, Katrin; Bondarenko, Olesja; Vija, Heiki; Adamberg Kaarel; Adamberg, Signe; Alamäe, Tiina. (2016). Enzymatic synthesis and ways of further treatment of fructooligosaccharides and polymeric levan for prebiotic efficiency studies. New Biotechnology, 33: 17th European Congress on Biotechnology; Krakov, Poland; 3-6.07.2016. ELSEVIER, S122−123. DOI: 10.1016/j.nbt.2016.06.1148.
5.2.
2016
Blinova, I.; Vija, H.; Kurvet, I.; Kahru, A. (2016). Ecotoxicological evaluation of technology-critical elements. Book of Abstracts: Interfaces Against Pollution, Environmental Challenges & Opportunities: Interfaces Against Pollution (IAP2016), Lleida, Spain, 4.-7. september 2016. Spain: Universitat de Lleida, 129.
5.2.
2016
Kahru, A.; Blinova, I.; Kurvet, I.; Juganson, K.; Vija, H.; Joonas, E. and Syvertsen-Wiig, G. (2016). Effects of (doped) rare earth oxides on algae, bacteria, protozoa and crustaceans. Book of Abstracts: Interfaces Against Pollution, Environmental Challenges & Opportunities: Interfaces Against Pollution (IAP2016), Lleida, Spain, 4.-7. september 2016. Spain: Universitat de Lleida, 160.
5.2.
2016
Muna, M.; Heinlaan, M.; Blinova, I.; Vija, H.; Kahru, A. (2016). Exposure of Freshwater Zooplankton to Copper Nanoparticles: Toxicity and Copper Body Burden. Book of Abstracts: EcoBalt 2016. Tartu: EcoBalt2016, 33.
5.2.
2016
Mardo, K.; Visnapuu, T.; Aasamets, A.; Kõrgesaar, K; Vija, H.; Alamäe, T. (2016). NOVEL PREBIOTIC FRUCTOOLIGOSACCHARIDES PREPARED BY ENZYMATIC SYNTHESIS AND DEGRADATION OF LEVAN. In: 3rd Congress of Baltic Microbiologists, Vilnius, 18-21 October 2016. 3rd Congress of Baltic Microbiologists, Vilnius, 18-21 October 2016.
5.2.
2016
Heinlaan, M.; Muna, M.; Vija, H.; Blinova, H.; Kahru, A. (2016). At Equitoxic Concentrations, CuO Nanoparticles Lead to Higher Copper Body Burden in Daphnia magna Compared to Soluble Cu-salt. Abstract Book of 8th Int Nanotoxicology Congress: 8th Int Nanotoxicology Congress, June 1-4, Boston, USA. Boston, USA: 8th Int Nanotoxicology Congress, June 1-4, Boston, USA, 122−122.
5.2.
2016
Heinlaan, Margit; Muna, Marge; Vija, Heiki; Slaveykova, Vera; Kahru, Anne (2016). Exposure to sublethal concentrations of metal nanoparticles may lead to disturbed feeding behavior and elevated metal body burden of Daphnia magna. Abstract Book: SETAC Europe 2016, Nantes, France 22-26.05.2016. Setac, TU037−TU037.
1.1.
2015
Ivask, A.; Titma, T.; Visnapuu, M.; Vija, H.; Kakinen, A.; Sihtmae, M.; Pokhel, S.; Madler, L.; Heinlaan, M.; Kisand, V.; Shimmo, R.; Kahru, A. (2015). Toxicity of 11 Metal Oxide Nanoparticles to Three Mammalian Cell Types In Vitro. Current Topics in Medicinal Chemistry, 15 (18), 1914−1929. DOI: doi.org/10.2174/1568026615666150506150109.
3.2.
2015
Jõgi, E; Metsla, K; Visnapuu, T; Aasamets, A; Vija, H; Alamäe, T. (2015). Synthesis and purification of functional fructans. Proceedings of the 11th International Conference on Polysaccharides-Glycoscience.: 11th International Conference on Polysaccharides-Glycoscience, 7-9 October, Prague, Czeck Republic. Ed. Rapkova, R; Copikova, J; Šarka, E. Czech Chemical Society, 5−9.
5.2.
2015
Visnapuu, T; Aasamets, A; Jõgi, E; Metsla, K; Vija, H; Adamberg, S; Alamäe, T. (2015). Levansucrase Lsc3 as a feasible catalyst for the synthesis of novel prebiotics. The 4th Beneficial Microbes Conference 16-18 March 2015, the Netherlands.
5.2.
2015
Jõgi, Erik; Viigand, Katrin; Metsla, Kati; Visnapuu, Triinu; Vija, Heiki; Alamäe, Tiina (2015). Yeast-aided Purification of Levansucrase-produced Prebiotic Fructooligosaccharides. 32nd International Specialized Symposium on Yeasts, 13-17 September 2015, Perugia, Italy.
5.2.
2015
Kahru, A.; Aruoja, V.; Ivask, A.; Pokhrel, S.; Madler, L.; Sihtmäe, M.; Käkinen, A.; Vija, H. (2015). Toxicity of 11 Metal Oxide Nanoparticles: FP7 project MODERN. Book of Abstracts, CompNanoTox, European Conference on Computational Nanotoxicology, 4-6 November 2015, Malaga, Spain: European Conference on Computational Nanotoxicology, Malaga, Spain, 4-6 November 2015. , 63−63.
1.1.
2014
Mardo, Karin; Visnapuu, Triinu; Gromkova, Maria; Aasamets, Anneli; Viigand, Katrin; Vija, Heiki; Alamäe, Tiina. (2014). High-Throughput Assay of Levansucrase Variants in Search of Feasible Catalysts for the Synthesis of Fructooligosaccharides and Levan. Molecules, 19 (6), 8434−8455. DOI: 10.3390/molecules19068434.
1.1.
2014
Ivask, A.; Kurvet, I.; Kasemets, K.; Blinova, I.; Aruoja, V.; Suppi, S.; Vija, H.; Käkinen, A.; Titma, T.; Heinlaan, M.; Visnapuu, M.; Koller, D.; Kisand, V.; Kahru, A. (2014). Size-dependent Toxicity of Silver Nanoparticles to Bacteria, Yeast, Algae, Crustaceans and Mammalian Cells in Vitro. PLoS ONE, 9 (7), e102108.
1.1.
2014
Mardo, Karin; Visnapuu, Triinu; Vija, Heiki; Elmi, Triin; Alamäe, Tiina (2014). Mutational analysis of conserved regions harbouring catalytic triad residues of the levansucrase protein encoded by lsc-3 (lsc3) gene of Pseudomonas syringae pv. tomato DC3000. Biotechnology and Applied Biochemistry, 61 (1), 11−22. DOI: 10.1002/bab.1129.
1.1.
2014
Adamberg, Signe; Tomson, Katrin; Vija, Heiki; Puurand, Marju; Kabanova, Natalja; Visnapuu, Triinu; Jõgi, Eerik; Alamäe, Tiina; Adamberg, Kaarel (2014). Degradation of fructans and production of propionic acid by Bacteroides thetaiotaomicron are enhanced by the shortage of amino acids. Frontiers in Nutrition, 1 (21), 1−10. DOI: 10.3389/fnut.2014.00021.
3.1.
2014
Aasamets, Anneli; Visnapuu, Triinu; Vija, Heiki; Jõgi, Eerik; Alamäe, Tiina (2014). Production of levan and fructooligosaccharides using levansucrase of Pseudomonas syringae pv. tomato. Proceedings of the 10th International Conference on Polysaccharides-Glycoscience: 10th International Conference on Polysaccharides-Glycoscience. Ed. Copikova, J; Šarka, E. Prague, Czech Republic: Czech Chemical Society, 12−16.
3.4.
2014
Adamberg, S.; Tomson, K.; Vija, H.; Visnapuu, T.; Adamberg, K. (2014). Co-metabolism of amino acids and polyfructans by Bacteroides thetaiotaomicron in defined media. ENGIHR Conference, Karlsruhe, 24-26. September 2014; http://www.engihr.eu/2014-engihr-conference/.
5.1.
2014
Aruoja, V.; Pokhrel, S.; Sihtmäe, M.; Vija, H.; Kahru, A. (2014). Mechanisms behind toxicity of 11 metal oxide nanoparticles to alga Pseudokirchneriella subcapitata. Toxicology Letters, 229 (229), S187−S187.
5.1.
2014
Visnapuu, Triinu; Aasamets, Anneli; Mardo, Karin; Jõgi, Eerik; Vija, Heiki; Alamäe, Tiina (2014). Synthesis of potential prebiotics using Pseudomonas syringae DC3000 levansucrase Lsc3. New Biotechnology, 31: 16th European Congress on Biotechnology, Edinburgh (UK) 13-16.07.2014. , S17. DOI: 10.1016/j.nbt.2014.05.1652.
5.2.
2014
Ivask, Angela; Visnapuu, Triinu; Bondarenko, Olesja; Vija, Heiki; Titma, Tiina; Alamäe, Tiina (2014). Functional Food Ingredients: synthesis and characterization of nanoparticles coated with levan from Pseudomonas syringae DC3000 and evaluation of their in vitro effects on bacteria and mammalian cells. Book of abstracts: 2nd Congress of Baltic Microbiologists, Tartu.
5.2.
2014
Jõgi, Eerik; Visnapuu, Triinu; Vija, Heiki; Alamäe, Tiina (2014). The production of fructooligosaccharides with P. syringae pv. tomato DC3000 levansucrase Lsc3 and purification of polymerization products. International Scientific Conference on Probiotics and Prebiotics (IPC2014); Budapest, Hungary; 24-26.06.2014.
5.2.
2014
Aasamets, Anneli; Visnapuu, Triinu; Vija, Heiki; Jõgi, Eerik; Alamäe, Tiina (2014). Optimization of reaction conditions for cost-efficient production of levan and fructooligosaccharides using levansucrase of Pseudomonas syringae DC3000. 2nd Congress of Baltic Microbiologists, Tartu, Estonia, 16.-19.10.
5.2.
2014
Adamberg, S.; Tomson, K.; Vija, H.; Puurand, M.; Adamberg, K. (2014). Functional Food Ingredients: metabolism of fructans by Bacteroides thetaiotaomicron and colon microbiota studied by isothermal microcalorimetry. Second Congress of Baltic Microbiologists, Tartu, 17 - 18 October, 2014.
1.1.
2013
Samel, Mari; Vija, Heiki; Kurvet, Imbi; Künnis-Beres, Kai; Trummal, Katrin; Subbi, Juhan; Kahru, Anne; Siigur, Jüri (2013). Interactions of PLA2-s from Vipera lebetina, Vipera berus berus and Naja naja oxiana Venom with Platelets, Bacterial and Cancer Cells. Toxins, 5, 203−223. DOI: 10.3390/toxins5020203.
3.4.
2013
Adamberg, S.; Tomson, K.; Vija, H.; Wadström, T.; Ljungh, Å.; Adamberg, K. (2013). Can isothermal microcalorimetry be used to characterise bacterial growth on prebiotic oligosaccharides? ENGIHR Conference, Valencia (Spain), 18-20 September 2013.
5.1.
2013
Siigur, Ene; Trummal, Katrin; Tõnismägi, Külli; Aaspõllu, Anu; Samel, Mari; Vija, Heiki; Siigur, Jüri (2013). Vipera lebetina (snake) venom components affecting hemostasis. Journal of Thrombosis and Haemostasis, 11 (Supplement 2), 893−893.
5.2.
2013
Visnapuu, Triinu; Mardo, Karin; Vija, Heiki; Mäe, Andres (2013). Mutational analysis of conserved regions of the levansucrase Lsc3 from Pseudomonas syringae DC3000. EuroCarb17. 17th European Carbohydrate Symposium, Tel-Aviv, Israel, 7.-11.07..
5.2.
2012
Kahru, A.; Mortimer, M.; Blinova, I.; Bondarenko, O.; Kurvet, I.; Ivask, A.; Vija, H.; Käkinen, A.; Kanarbik, L.; Juganson, K.; Aruoja, V.; Sihtmäe, M.; Künnis, K. (2012). Comparative study of physico-chemical properties and biological effects of silver and silica nanoparticles to bacteria and environmentally relevant non-vertebrate species. Nordic environmental chemistry conference (NECC 2012). Harjattula Manor on Kakskerta, Åbo/Turku, Finland on June 4-7, 2012..
1.1.
2011
Siigur, Ene; Tõnismägi, Külli; Trummal, Katrin; Samel, Mari; Vija, Heiki; Aaspõllu, Anu; Rönnholm, Gunilla; Subbi, Juhan; Kalkkinen, Nisse; Siigur, Jüri. (2011). A new tyrosine-specific chymotrypsin-like and angiotensin-degrading serine proteinase from Vipera lebetina snake venom. Biochimie, 93, 321−330.10.1016/j.biochi.2010.10.004.
5.1.
2011
Siigur, Ene; Trummal, Katrin; Samel, Mari; Tonismagi, Kylli; Vija, Heiki; Subbi, Juhan; Siigur, Juri (2011). Multifunctional metalloproteinase from Vipera Lebetina venom. Journal of Thrombosis and Haemostasis, Volume 9: XXIII Congress of the International Society on Thrombosis and Haemostasis. Ed. Greaves, Mike; Lane, David; Ozaki, Yukio;. Kyoto: Wiley-Blackwell,. (Supplement; 2).
5.2.
2011
Käkinen, Aleksandr; Vija, Heiki; Bondarenko, Olesja; Juganson, Katre; Blinova, Irina; Kahru, Anne. (2011). Physico-chemical Characterisation of Silver and Copper Nanoparticles for Ecotoxicological Studies. Book of Abstracts: 14th IUPAC International Symposium on Macro Molecular Complexes, MMC-14, Helsinki, Soome 14-17.08.2011. , 201−201.
5.2.
2011
Samel, Mari; Vija, Heiki ; Kurvet, Imbi; Subbi, Juhan; Kahru, Anne; Siigur, Jüri. (2011). Antiplatelet, antibacterial and anticancer effect of PLA2-S from Vipera lebetina, Vipera berus berus and Naja naja oxiana venom. PROGRAM&ABSTRACTS BOOK; http://istmeetingvlc2011.ibv.csic.es: 17th Congress of the European Section of the INTERNATIONAL SOCIETY on TOXINOLOGY September 11-15,2011, Valencia, Spain. Valencia, 160−160.
1.1.
2010
Pochard, I.; Labbez, C.; Nonat, A.; Vija, H.; Jönsson, B. (2010). The effect of polycations on early cement paste. Cement and Concrete Research, 40, 1488−1494.
1.1.
2010
Sepp, Mervi; Vendelin, Marko; Vija, Heiki; Birkedal, Rikke (2010). ADP Compartmentation analysis reveals coupling between pyruvate kinase and ATPases in heart muscle. Biophysical Journal, 98 (12), 2785−2793.10.1016/j.bpj.2010.03.025.
1.1.
2010
Siigur, Jüri; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Rönnholm, Gunilla; Kalkkinen, Nisse; Siigur, Ene. (2010). Separation and analysis of peptides and proteins from Vipera lebetina snake venom. Procedia Chemistry, 2, 109−115.
5.1.
2010
Siigur, Jüri; Trummal, Katrin; Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Siigur, Ene; Subbi, Juhan. (2010). Specificity Studies of Proteinases from Vipera lebetina Snake Venom. Journal of Thrombosis and Haemostasis, 8 (Supplement s1), 54−54.
5.1.
2010
Sepp, Mervi; Vendelin, Marko; Vija, Heiki; Birkedal, Rikke (2010). Analysis of intracellular ADP compartmentation reveals functional coupling between pyruvate kinase and ATPases in rat cardiomyocytes. Biophysical Journal, 98, 734a. DOI: 10.1016/j.bpj.2009.12.4027.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan; Siigur, Jüri. (2009). Purification, characterization, and cDNA cloning of acidic platelet aggregation inhibiting phospholipases A2 from the snake venom of Vipera lebetina (Levantine viper). Toxicon, 54 (4), 429−439. DOI: 10.1016/j.toxicon.2009.05.010.
1.1.
2009
Paalme, Viiu; Trummal, Katrin; Samel, Mari; Tõnismägi, Külli; Järvekülg, Lilian; Vija, Heiki; Subbi, Juhan; Siigur, Jüri; Siigur, Ene (2009). Nerve growth factor from Vipera lebetina venom. Toxicon, 54 (3), 329−336. DOI: 10.1016/j.toxicon.2009.05.001.
1.1.
2009
Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.
1.1.
2009
Vija, Heiki; Samel, Mari; Siigur, Ene; Aaspõllu, Anu; Tõnismägi, Külli; Trummal, Katrin; Subbi, Juhan; Siigur, Jüri (2009). VGD and MLD-motifs containing heterodimeric disintegrin viplebedin-2 from Vipera lebetina snake venom Purification and cDNA cloning. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 153, 253−260. DOI: 10.1016/j.cbpb.2009.03.002.
1.1.
2009
Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu; Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.
1.1.
2009
Vija, Heiki; Kesvatera, Tõnu (2009). The effect of solvent composition on complex formation of S100B protein with peptides. Proceedings of the Estonian Academy of Sciences, 58 (1), 67−72.
5.1.
2009
Siigur, Ene; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Subbi, Juhan; Siigur, Jüri (2009). Haemostasis affecting proteases from Vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 7, PP-MO-149−PP-MO-149.
5.2.
2009
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Subbi, Juhan;Siigur, Ene (2009). Acidic Platelet Aggregation Inhibiting Phospholipas A2s from the Snake Venom of Vipera lebetina (Levantine viper). EFATH 2009: 4th International Conference on Exogenous Factors Affecting Thrombosis and Haemostasis, Boston Massachusetts USA, 17-19 July. Boston, Massachusetts, 20.
5.2.
2009
Siigur, J; Vija, H; Samel, M; Tõnismägi, K; Trummal, K; Aaspõllu, A; Subbi, J; Rönnholm, G; Kalkkinen, N; Siigur, E. (2009). Separation and Analysis of Peptides and Proteins from Vipera Lebetina Snake Venom. NoSSS2009 5thConference on Separation and Related Techniques by Nordic Separation Science Society, Tallinn Universityof Technology, 26-29 August 2009. Tallinna Tehnikaülikooli Kirjastus, 133−133.
1.1.
2008
Samel, M.; Tõnismägi, K.; Rönnholm, G.; Vija, H.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2008). L-Amino acid oxidase from Naja naja oxiana venom. Comparative Biochemistry and Physiology, 149 (4), 572−580. DOI: 10.1016/j.cbpb.2007.11.008.
5.2.
2008
Siigur, Jüri; Vija, Heiki; Samel, Mari; Aaspõllu, Anu; Trummal, Katrin; Subbi, Juhan; Siigur, Ene (2008). Acidic platelet aggregation inhibiting phospholipase A2 from Vipera lebetina snake venom In:16th European Section Meeting of the International Society on Toxinology, Book of abstracts, Leuven,Belgium, 7-10 September 2008 pp.54-55. 16th European Section Meeting of the International Society on Toxinology, Book of abstracts: 16th European Section Meeting of the International Society on Toxinology; Leuven,Belgium, 7-10 September 2008. Ed. Jan Tytgat. Leuven, 54−55.
1.3.
2007
Vija, Heiki; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Aaspõllu, Anu; Siigur, Ene; Siigur, Jüri. (2007). Heterodimeric disintegrin and phospholipase A2 from Vipera lebetina snake venom. Latvijas Kimijas Žurnals (Latvian Journal of Chemistry), 3, 291−292.
5.1.
2007
Siigur, Ene; Samel, Mari; Tõnismägi, Külli; Vija, Heiki; Trummal, Katrin; Aaspõllu, Anu; Pikver, Rein; Subbi, Juhan; Siigur, Jüri (2007). Platelet aggregation inhibiting components from vipera lebetina snake venom. Journal of Thrombosis and Haemostasis, 5: XXI congress of the International Society on Thrombosis and Haemostasis, Geneva, Switzerland, 6-12 July 2007. P-S-272−P-S-272. (Supplement 2).
1.1.
2006
Samel, M.; Vija, H.; Rönnholm, G.; Siigur, J.; Kalkkinen, N.; Siigur, E. (2006). Isolation and characterization of an apoptotic and platelet aggragation inhibiting L-amino acid oxidase from Vipera berus berus (common viper) venom. Biochimica et Biophysica Acta, 1764, 707−714.
5.2.
2006
Siigur, Jüri; Vija, Heiki; Aaspõllu, Anu; Samel, Mari; Tõnismägi, Külli; Trummal, Katrin; Pikver, Rein; Subbi, Juhan; Siigur, Ene. (2006). Heterodimeric Disintegrin VLT-2 from Vipera lebetina Snake Venom. 15th World Congress on Animal, Plant and Microbial Toxins, Abstract Book: 15th World Congress on Animal, Plant and Microbial Toxins, Glasgow, Scotland, 23-28 july 2006. 275−275.
1.1.
2005
Siigur, J.; Tonismagi, K.; Trummal, K.; Aaspollu, A; Samel, M; Vija, H; Subbi, J; Kalkkinen, N.; Siigur, E. (2005). Vipera lebetina Venom Contains All Types of Snake Venom Metalloproteases. Pathophysiology of haemostasis and thrombosis., 34, 209−214.
1.1.
2003
Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2003). Metalloproteinase with factor X activating and fibrinogenolytic activities from Vipera berus berus venom. Comparative Biochemistry and Physiology, 135B, 575−582.
1.1.
2003
Vallikivi, I.; Lille, Ü.; Lõokene, A.; Metsala, A.; Sikk, P.; Tõugu, V.; Vija, H.; Villo, L.; Parve, O. (2003). Lipase action on some non-triglyceride substrates. Journal of Molecular Catalysis B: Enzymatic, 22, 279−298. DOI: 10.1016/S1381-1177(03)00043-2.
5.2.
2003
Siigur, Jüri; Aaspõllu, Anu; Trummal, Katrin; Tõnismägi, Külli; Samel, Mari; Vija, Heiki; Tammiste, Indrek; Siigur, Ene. (2003). HETERODIMERIC DISINTEGRINS IN Vipera lebetina SNAKE VENOM GLANDARE SYNTHESIZED FROM DIFFERENT GENES. 14th World Congress on Animal, Plant and Microbial Toxins, Programme&Abstract Book: 14th World Congress on Animal, Plant and Microbial Toxins, Adelaide, Australia, 14-19September 2003. Ed. Julian White and Vaughan Williams. 29−29.
1.1.
2002
Siigur, J.; Trummal, K.; Tõnismägi, K.; Samel, M.; Siigur, E.; Vija, H.; Tammiste, I.; Subbi, J. (2002). Use of MALDI-TOF mass spectrometry for specificity studies of biomedically important proteases. Spectroscopy, 16, 161−170.
5.2.
2002
Kesvatera, T.; Jönsson, B.; Telling, A.; Tõugu, V.; Vija, H.; Thulin, E.; Linse, S. (2002). pKa Shifts of Ionizable Groups in Folded Apo Calbindin D9k and Their Manifestation in Ca2+ Binding. 1: The Lise Meitner Symposium: Current Progress in Protein Folding and Design, March 26-27, 2002, Lund, Sweden. Lund, Rootsi,.
1.1.
2001
Siigur, E.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, J. (2001). Factor X activator from Vipera lebetina snake venom, molecular characterization and substrate specificity. Biochimica et Biophysica Acta, 1568 (1), 90−98.
1.1.
2001
Siigur, J.; Aaspõllu, A.; Tõnismägi, K.; Trummal, K.; Samel, M.; Vija, H.; Subbi, J.; Siigur, E. (2001). Proteases from Vipera lebetina venom affecting coagulation and fibrinolysis. Haemostasis, 31 (3), 123−132.
1.1.
2001
Kesvatera, T.; Jönsson, B.; Telling, A.; Tõugu, V.; Vija, H.; Thulin, E.; Linse, S. (2001). Calbindin D9k: A Protein Optimized for Calcium Binding at Neutral pH. Biochemistry, 40 (50), 15334−15340.
1.1.
2001
Seppet, EK.; Kaambre, T.; Sikk, P.; Tiivel, T.; Vija, H.; Tonkonogi, M.; Sahlin, K.; Kay, L.; Appaix, F.; Braun, U.; Eimre, M.; Saks, VA. (2001). Functional complexes of mitochondria with Ca,MgATPases of myofibrils and sarcoplasmic reticulum in muscle cells. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1504, 379−395. DOI: 10.1016/S0005-2728(00)00269-3.
1.1.
2000
Trummal, K.; Vija, H.; Subbi, J.; Siigur, J. (2000). MALDI-TOF mass spectrometry analysis of substrate specificity of lebetase, a direct-acting fibrinolytic metalloproteinase from Vipera lebetina snake venom. Biochimica et Biophysica Acta, 1476 (2), 331−336.
1.1.
1999
Käämbre, T.; Tõugu, V.; Käämbre, P.; Vija, H.; Sikk, P. (1999). Hydrolysis of emulsified mixtures of triacylglycerols by pancreatic lipase. Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology, 1431 (1), 97−106. DOI: 10.1016/S0167-4838(99)00047-3.
1.1.
1997
Vija, H.; Telling, A.; Tõugu, V. (1997). Lipase-catalyzed synthesis of iso-amyl acetate in supercritical carbon dioxide and in hexane. Bioorganic & Medicinal Chemistry Letters, 7 (3), 259−262.
1.1.
1997
Parve, O.; Vallikivi, I.; Lahe, L.; Metsala, A.; Lille, U.; Tougu, V.; Vija, H.; Pehk, T (1997). Lipase-catalysed enantioselective hydrolysis of bicyclo[3.2.0]heptanol esters in supercritical carbon dioxide. Bioorganic & Medicinal Chemistry Letters, 7 (7), 811−816.
1.1.
1997
Parve, O.; Vallikivi, I.; Metsala, A.; Lille, Ü.; Tõugu, V.; Sikk, P.; Käämbre, T.; Vija, H.; Pehk, T (1997). Lipase-catalysed enantioselective hydrolysis: Interpretation of the kinetic results in terms of frontier orbital localisation. Tetrahedron, 53 (13), 4889−4900.
3.5.
1996
Lille, Ülo; Metsala, Andrus; Parve, Omar; Tõugu, Vello; Vija, Heiki. (1996). "Lipolase" allub sekundaarsete alkoholide enantioeelistuse üldisele reeglile nii vesi- kui ka superkriitilise (SK)SO2 keskkonnas. XVII Eesti keemiapäevad : teaduskonverentsi ettekannete referaadid = 17th Estonian Chemistry Days : abstracts of scientific conference. Tartu: TTY puuduv kirjastus, 101−102.
1.1.
1989
Pehk, T; Haga, M; Vija, H; Lippmaa, E. (1989). High-fieldD 2D NMR-Spectroscopy of Amanitin isomers. Magnetic Resonance in Chemistry, 27, 173−183.

Industrial property

13.03.2021

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
PRGPRG749Antimikroobsed kitosaani nanokomposiidid biomeditsiinilisteks rakendusteks: efektiivsus ja ohutus01.01.202031.12.2024Kaja KasemetsKeemilise ja Bioloogilise Füüsika Instituut514 250,00 EUR
ETFETF7251Biomeditsiiniliselt olulised valgud ja peptiidid madude mürkidestl01.01.200731.12.2010Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut54 053,92 EUR
SFSF0222603s03Funktsionaalne proteoomika - struktuuri-aktiivsuse seosed ning molekulaarne äratundmine looduslikes valgukooslustes01.01.200331.12.2007Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut643 270,75 EUR
ETFETF5554Hemostaasi, angiogeneesi ja apoptoosi mõjutavad valgud viperiidsete madude mürkidest.01.01.200331.12.2006Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut29 542,52 EUR
PUT; PUT_OPPUT748In vitro toksikoloogilisete meetodite arendamine uute antimikroobsete nanomaterjalide eesmärgipäraseks disainiks01.01.201531.05.2018Angela IvaskKeemilise ja Bioloogilise Füüsika Instituut268 620,00 EUR
SFSF0180114Bs08Integreeritud energeetilise metabolismi regulatsioonimehhanismid lihasrakkudes01.01.200831.12.2013Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut657 119,57 EUR
MUUKBFI,MG-11Kütusest väävli eraldamise adsorbendi süntees ja uurimine19.07.201130.09.2011Heiki VijaKeemilise ja Bioloogilise Füüsika Instituut9 600,00 EUR
ETFETF8899Maomürkide valgud ja peptiidid kui bioloogiliste protsesside modulaatorid01.01.201131.12.2014Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut48 000,00 EUR
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