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Olen nõus

Jaanus Remme

https://www.etis.ee/CV/Jaanus_Remme/est
18.12.1953
737 5031
507 1261 (5031)
jaanus.remme@ut.ee
A-4614-2011

Teenistuskäik

Töökohad ja ametid
01.01.2016–31.08.2019   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut, molekulaarbioloogia professor (1,00)
1997–...   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, Professor (1,00)
1980-1995 KBFI insensr, grupijuht, teadur, vanemteadur
1993-1997 Tartu Ülikool van. teadur, dotsent
1997 Tartu Ülikool, professor
01.01.2008–31.08.2012   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, õppetooli juhataja
01.01.2008–31.12.2015   
Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, molekulaarbioloogia professor (1,00)
01.09.2007–31.12.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, õppetooli juhataja
01.09.2007–31.12.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, molekulaarbioloogia professor (1,00)
01.09.2006–31.08.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, juhataja
01.09.2002–31.08.2007   
Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut, molekulaarbioloogia professor (1,00)
 
 
Haridustee
1972. Tallinna spordi-internaatkool
1980. Tartu Ülikool Bioloogia-Geograafia teadusk., bioloog-geneetik
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2005−...   
Ajakira Eesti TA Toimetised, keemia seeria toimetuse kolleegiumi liige
2005−2020   
TÜMRI nõukogu liige
2005−2015   
Ajakirja Central European Journal of Biology (VERSITA) toimetuse kolleegiumi liige
2003−2003   
2003, umbes 1 kuu TÜMRI juhataja
 
 
Teenistuskäigu lisainfo
Lisainfo puudub;

Kvalifikatsioon

Teaduskraadid
Jaanus Remme, doktorikraad, 1993, (juh) Richard Villems, Studies of the peptidyltransferase centre of the E. coli ribosome, Tartu Ülikool, Bioloogia-geograafiateaduskond.
 
 
Teaduspreemiad ja tunnustused
2013, Jaanus Remme, Uurimuste tsükli “Ribosoomide biogenees ja funktsioneerimine bakterites” eest
2002, Jaanus Remme, Valgetähe orden 3. klass
2000, Jaanus Remme, HHMI International Research Award 2001 - 2005 "Functional Importance of the transient rRNA structures during ribosome large subunit assembly in E. coli
 
 
Teadustöö põhisuunad
VALDKOND: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; PÕHISUUND: Valgu biosüntees, RNA bioloogia
VALDKOND: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; PÕHISUUND: Valgu biosüntees, ribosoomide biogenees, RNA struktuur ja funktsioonid
VALDKOND: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia; CERCS ERIALA: P320 Nukleiinhappesüntees, proteiinisüntees ; PÕHISUUND: Valkude ja RNA sünteesil osalevate makromolekulide ja nende komplekside struktuur ja funktsioonid. Valkude biosüntees, ribosoomi biogenees.
 
 
Lisainfo
filosoofiadoktor
Tartu Ülikool, 1993

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Lilleorg, Silva; Reier, Kaspar; Pulk, Arto; Liiv, Aivar; Tammsalu, Triin; Peil, Lauri; Cate, JamieH D; Remme, Jaanus (2019). Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase. Biochimie, 156, 169−180.10.1016/j.biochi.2018.10.013.
1.1.
2019
Kisly, I., Remme, J., Tamm, T. (2019). Ribosomal protein eL24, involved in two intersubunit bridges, stimulates translation initiation and elongation. Nucleic Acids Research, 47 (1), 406−420.10.1093/nar/gky1083.
1.1.
2019
Aleksashin NA, Leppik M, Hockenberry AJ, Klepacki D, Vázquez-Laslop N, Jewett MC, Remme J, Mankin AS. (2019). Assembly and functionality of the ribosome with tethered subunits. Nature Communications, 10 (1), 930.10.1038/s41467-019-08892-w.
1.1.
2019
Ainelo, Andres; Porosk, Rando; Kilk, Kalle; Rosendahl, Sirli; Remme, Jaanus; Horak, Rita (2019). Pseudomonas putida Responds to the Toxin GraT by Inducing Ribosome Biogenesis Factors and Repressing TCA Cycle Enzymes. Toxins, 11 (2), ARTN 103.10.3390/toxins11020103.
1.1.
2018
O’Connor,Michael; Leppik,Margus; Remme, Jaanus (2018). Pseudouridine-Free Escherichia coli Ribosomes. Journal of Bacteriology, 200 (4), e00540-17.10.1128/JB.00540-17.
1.1.
2017
Mets, Toomas; Lippus, Markus; Schryer, David; Liiv, Aivar; Kasari, Villu; Paier, Anton; Maiväli, Ülo; Remme, Jaanus; Tenson, Tanel; Kaldalu, Niilo (2017). Toxins MazF and MqsR cleave Escherichia coli ribosomal RNA precursors at multiple sites. RNA Biology, 14 (1), 124−135.10.1080/15476286.2016.1259784.
1.1.
2017
Lilleorg, Silva; Reier, Kaspar; Remme, Jaanus; Liiv, Aivar (2017). The Intersubunit Bridge B1b of the Bacterial Ribosome Facilitates Initiation of Protein Synthesis and Maintenance of Translational Fidelity. Journal of Molecular Biology, 429 (7), 1067−1080.10.1016/j.jmb.2017.02.015.
1.1.
2017
Leppik, Margus; Liiv, Aivar; Remme, Jaanus (2017). Random pseuoduridylation in vivo reveals critical region of Escherichia coli 23S rRNA for ribosome assembly. Nucleic Acids Research, 45 (10), 6098−6108.10.1093/nar/gkx160.
1.1.
2016
Ainelo, Andres; Tamman, Hedvig; Leppik, Margus; Remme, Jaanus; Hõrak, Rita (2016). The toxin GraT inhibits ribosome biogenesis. Molecular Microbiology, 719−734.10.1111/mmi.13344.
1.1.
2016
Kisly, Ivan; Gulay, Suna P.; Mäeorg, Uno; Dinman, Jonathan D.; Remme, Jaanus; Tamm, Tiina. (2016). The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome. Journal of Molecular Biology, 428 (10), 2203−2216.10.1016/j.jmb.2016.03.023.
1.1.
2014
Starosta, AL; Lassak, J; Peil, L; Atkinson, GC; Virumäe, K; Tenson, T; Remme, J; Jung, K; Wilson, DN. (2014). Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site. Nucleic Acids Research, 42 (16), 10711−10719.10.1093/nar/gku768.
1.1.
2014
Piir, K.; Tamm, T.; Kisly, I.; Tammsalu, T.; Remme, J. (2014). Stepwise Splitting of Ribosomal Proteins from Yeast Ribosomes by LiCl. PLoS ONE, 9 (7), e101561.10.1371/journal.pone.0101561.
1.1.
2014
Starosta, Agata L.; Lassak, Jürgen; Peil, Lauri; Atkinson, Gemma C.; Woolstenhulme, Christopher J.; Virumäe, Kai; Buskirk, Allen; Tenson, Tanel; Remme, Jaanus; Jung, Kirsten; Wilson, Daniel N. (2014). A conserved proline triplet in Val-tRNA synthetase and the origin of elongation factor P. Cell Reports, 9 (2), 476−483.10.1016/j.celrep.2014.09.008.
1.1.
2013
Peil, L.; Starosta, AL.; Lassak, J.; Atkinson, GC; Virumäe, K.; Spitzer, M.; Tenson, T.; Jung, K.; Remme, J.; Wilson, DN. (2013). Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P. Proceedings of the National Academy of Sciences of the United States of America, 110 (38), 15265−15270.10.1073/pnas.1310642110.
1.1.
2013
Samhita, L.; Virumäe, K.; Remme, J.; Varshney, U. (2013). Initiation with elongator tRNAs. Journal of Bacteriology, 195 (18), 4202−4209.10.1128/JB.00637-13.
1.1.
2012
Leppik, M., Ero, R., Liiv, A., Kipper, K., Remme, J. (2012). Different sensitivity of H69 modification enzymes RluD and RlmH to mutations in Escherichia coli 23S rRNA. Biochimie, 94 (5), 1080−1089.
1.1.
2012
Peil, L.; Starosta, A.; Virumäe, K.; Atkinson, G.C.; Tenson, T.; Remme, J.; Wilson, D.N. (2012). Lysine 34 of translation elongation factor EF-P is hydroxylated by YfcM. Nature Chemical Biology, 8 (8), 695−697.10.1038/nchembio.1001.
1.1.
2011
Remme, J. (2011). How to avoid undesirable interactions during ribosome assembly? Molecular Microbiology, 82 (2), 269−271.10.1111/j.1365-2958.2011.07838.x.
1.1.
2011
Siibak, T.; Peil, L.; Dönhofer, A.; Tats, A.; Remm, M.; Wilson, D.; Tenson, T.; Remme, J. (2011). Antibiotic-induced ribosomal assembly defects result from changes in the synthesis of ribosomal proteins. Molecular Microbiology, 80 (1), 54−67.10.1111/j.1365-2958.2011.07555.x.
1.1.
2011
Kipper, K., Sild, S., Hetenyi, C., Remme, J., Liiv, A. (2011). Pseudouridylation of 23S rRNA helix 69 promotes peptide release by release factor RF2 but not by release factor RF1. Biochimie, 93 (5), 834−844.10.1016/j.biochi.2010.12.018.
1.1.
2010
Ero, R.; Leppik, M.; Liiv, A.; Remme, J. (2010). Specificity and kinetics of 23S rRNA modification enzymes RlmH and RluD. RNA-A Publication of the RNA Society, 16 (11), 2075 −2084.10.1261/rna.2234310.
1.1.
2010
Siibak, T.; Remme, J. (2010). Subribosomal particle analysis reveals the stages of bacterial ribosome assembly at which rRNA nucleotides are modified. RNA-A Publication of the RNA Society, 16 (10), 2023−2032.10.1261/rna.2160010.
1.1.
2010
Pulk, A.; Liiv, A.; Peil, L.; Maiväli, Ü.; Nierhaus, K.; Remme, J. (2010). Ribosome reactivation by replacement of damaged proteins. Molecular Microbiology, 75 (4), 801−814.10.1111/j.1365-2958.2009.07002.x.
1.1.
2009
Siibak, T; Peil, L;Xiong, L; Mankin, A;Remme, J;Tenson, T. (2009). Erythromycin- and Chloramphenicol-Induced Ribosomal Assembly Defects Are Secondary Effects of Protein Synthesis Inhibition. Chemotherapy Research and Practice, 53 (2), 563−571.
1.1.
2009
Kipper, K.; Hetényi, C.; Sild, S.; Remme, J.; Liiv, A. (2009). Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity. Journal of Molecular Biology, 385 (2), 405−422.10.1016/j.jmb.2008.10.065.
1.1.
2008
Ero, R.; Peil, L.; Liiv, A.; Remme, J. (2008). Identification of pseudouridine methyltransferase in Escherichia coli. RNA-A Publication of the RNA Society, 14 (10), 2223−2233.10.1261/rna.1186608.
1.1.
2008
Peil, L.; Virumäe, K.; Remme, J. (2008). Ribosome assembly in Escherichia coli strains lacking the RNA helicase DeaD/CsdA or DbpA. FEBS Journal, 275 (15), 3772−3782.10.1111/j.1742-4658.2008.06523.x.
1.1.
2007
Leppik, Margus; Peil, Lauri; Kipper, Kalle; Liiv, Aivar; Remme, Jaanus (2007). Substrate specificity of the pseudouridine synthase RluD in Escherichia coli. FEBS Journal, 274 (21), 5759−5766.
6.3.
2007
Maiväli, Ü.; Remme, J. (2007). Elu piirid. Rohtmets, I., Kukk, T. (_EditorsAbbr). Lehed ja tähed IV (78−85).. MTÜ Loodusajakiri.
1.1.
2006
Iskakova, E.; Szaflarski, W.; Dreyfus, M.; Remme, J.; Nierhaus, K. (2006). Troubleshooting coupled in vitro transcription–translation system derived from Escherichia coli cells: synthesis of high-yield fully active proteins. Nucleic Acids Research, 34 (19), e135.
1.1.
2006
Pulk, A; Maiväli, Ü; Remme, J. (2006). Identification of nucleotides in E. coli 16S rRNA essential for ribosome subunit association. RNA-A Publication of the RNA Society, 12 (5), 790−796.
1.1.
2005
Xu, JH.; Golshani, A.; Aoki, H.; Remme, J.; Chosay, J.; Shinabarger, DL.; Ganoza, MC. (2005). Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E-coli. Biochemical and Biophysical Research Communications, 328 (2), 471−476.
1.1.
2005
Liiv, A.; Karitkina, D.; Maivali, U.; Remme, J. (2005). Analysis of the function of E-coli 23S rRNA helix-loop 69 by mutagenesis. BMC Molecular Biology, 6, -.
1.1.
2004
Ougland, R.; Zhang, CM.; Liiv, A.; Johansen, RF.; Seeberg, E.; Remme, J.; Falnes, PO. (2004). AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Molecular Cell, 16 (1), 107−116.
1.1.
2004
Liiv, A.; Remme, J. (2004). Importance of transient structures during post-transcriptional refolding of the pre-23 S rRNA and ribosomal large subunit assembly. Journal of Molecular Biology, 342 (3), 725−741.
1.1.
2004
Maiväli, U.; Remme, J. (2004). Definition of bases in 23S rRNA essential for ribosomal subunit association. RNA-A Publication of the RNA Society, 10 (4), 600−604.
1.1.
2003
Allas, U.; Liiv, A.; Remme, J. (2003). Functional interaction between RNase III and the Escherichia coli ribosome. BMC Molecular Biology, 4, -.
1.1.
2002
Virumae, K.; Saarma, U.; Horowitz, J.; Remme, J. (2002). Functional importance of the 3 '-terminal adenosine of tRNA in ribosomal translation. Journal of Biological Chemistry, 277 (27), 24128−24134.
1.1.
2002
Maiväli, Ü.; Pulk, A.; Loogväli, EL.; Remme, J. (2002). Accessibility of phosphates in domain I of 23 S rRNA in the ribosomal 50 S subunit as detected by R-p phosphorothioates. Biochimica et Biophysica Acta - Gene Structure and Expression, 1579 (1), 1−7.
1.1.
2001
Ofengand, J.; Malhotra, A.; Remme, J.; Gutgsell, NS.; Del Campo, M.; Jean-Charles, S.; Peil, L.; Kaya, Y. (2001). Pseudouridines and psendouridine synthases of the ribosome. Cold Spring Harbor Symposia on Quantitative Biology, 66, 147−159.
1.1.
2001
Maivali, U.; Saarma, U.; Remme, J. (2001). Mutations in the Escherichia coli 23S rRNA increase the rate of peptidyl-tRNA dissociation from the ribosome. Molecular Biology, 35 (4), 569−574.
6.3.
1999
Remme, J.; Zobel, K. (1999). Uus aastatuhat ja loodusteaduste lõhenemine. Horisont, 5, 12−15.
1.1.
1998
Saarma, U.; Spahn, CMT.; Nierhaus, KH.; Remme, J. (1998). Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase center. RNA-A Publication of the RNA Society, 4 (2), 189−194.
1.1.
1998
Liiv, A.; Remme, J. (1998). Base-pairing of 23 S rRNA ends is essential for ribosomal large subunit assembly. Journal of Molecular Biology, 276 (3), 537−545.
1.1.
1998
Liiv, A.; Tenson, T.; Margus, T.; Remme, J. (1998). Multiple functions of the transcribed spacers in ribosomal RNA operons. Biological Chemistry, 379 (7), 783−793.
1.1.
1997
Saarma, U.; Remme, J.; Ehrenberg, M.; Bilgin, N. (1997). An A to U transversion at position 1067 of 23 S rRNA from Escherichia coli impairs EF-Tu and EF-G function. Journal of Molecular Biology, 272 (3), 327−335.
1.1.
1996
Liiv, A.; Tenson, T.; Remme, J. (1996). Analysis of the ribosome large subunit assembly and 23 S rRNA stability in vivo. Journal of Molecular Biology, 263 (3), 396−410.
1.1.
1996
Spahn, CMT.; Remme, J.; Schafer, MA.; Nierhaus, KH. (1996). Mutational analysis of two highly conserved UGG sequences of 23 S rRNA from Escherichia coli. Journal of Biological Chemistry, 271 (51), 32849−32856.
1.1.
1993
Lewicki, BTU.; Margus, T.; Remme, J.; Nierhaus, KH. (1993). Coupling of ribosomal-RNA transcription and ribosomal assembly invivo - formation of active ribosomal-subunits in escherichia-coli requires transcription of ribosomal-RNA genes by host RNA- polymerase which cannot be replaced by bacteriophage-t7 RNA- polyme. Journal of Molecular Biology, 231 (3), 581−593.
3.1.
1993
Saarma, U.; Lewicki, BTU.; Margus, T.; Nigul, S.; Remme, J. (1993). Analysis of mutations in the 23S rRNA. Nierhaus, K.H.; Franchesci, F.; Subramanian, A.R.; Erdmann, V.A.; Wittmann-Liebold, B.. The Translational Apparatus: structure, function, regulation, evolution (445−454).. New York: Plenum Press.
1.1.
1992
Saarma, U.; Remme, J. (1992). Novel mutants of 23s RNA - characterization of functional-properties. Nucleic Acids Research, 20 (12), 3147−3152.
3.1.
1990
Rheinberger, H.-J.; Geigenmüller, U.; Gnirke, A.; Hausner, T.-P.; Remme, J.; Saruyama, H.; Nierhaus, K. H. (1990). Allosteric three-site model for the ribosomal elongation cycle. The Ribosomes, Structure, Function and Genetics. _EditorsAbbr Hill, W.E.; Dahlberg, A.; Garrett, R.A.; Moore, P.B.; Schlessinger, D.; Warner, J.R. Washington, D.C.: American Society of Microbiology, 318−330.
1.1.
1989
Remme, J.; Margus, T.; Villems, R.; Nierhaus, KH. (1989). The 3rd ribosomal transfer RNA- binding site, the e-site, is occupied in native polysomes. European Journal of Biochemistry, 183 (2), 281−284.
1.1.
1986
Iusupova, GZ.; Remme, JL.; Belitsina, NV.; Spirin, AS. (1986). Template-free ribosomal synthesis of polylysine from individual lysyl-transfer RNA lys. Doklady Akademii Nauk SSSR, 289 (3), 725−728.
1.1.
1985
Maimets, T.O.; Remme, J. L.; Villems, R. L.-E. (1985). Stimulation of 50S subparticle peptidyl transferase activity of with alcohols. Molecular Biology, 19 (3), 510−515.
1.1.
1985
Remme, J.; Villems, R. (1985). On the physicochemical rationale of the genetic-code. FEBS Letters, 189 (2), 159−162.
1.1.
1985
Maimets, TO.; Remme, YL.; Villems, RlE. (1985). Stimulation of 50s-subparticle peptidyl transferase-activity with alcohols. Molecular Biology, 19 (3), 510−515.
1.1.
1985
Remme, J.; Metspalu, E.; Maimets, T.; Villems, R. (1985). The properties of the complex between ribosomal protein-l2 and transfer-rna. FEBS Letters, 190 (2), 275−278.
1.1.
1984
Maimets, T. O.; Ustav, M. B.; Remme, J. L.; Villems, R. L.-E. (1984). The L16 protein of the escherichia-coli ribosome: its possible role in protein biosynthesis. Molecular Biology, 18 (6), 1305−1313.
1.1.
1984
Maimets, T.; Remme, J.; Villems, R. (1984). Ribosomal protein L16 binds to the 3'-end of transfer-rna. FEBS Letters, 166 (1), 53−56.
1.1.
1984
Maimets, TO.; Ustav, MB.; Remme, YL.; Villems, RlE. (1984). The l16 protein of the escherichia-coli ribosome - possible role in protein-biosynthesis. Molecular Biology, 18 (6), 1305−1313.
1.1.
1983
Remme, J.; Maimets, T.; Ustav, M.; Villems, R. (1983). The interaction of ribosomal protein-l16 and its fragments with transfer-rna. FEBS Letters, 153 (2), 267−269.
1.1.
1979
Ustav, MB.; Remme, JL.; Lind, AJ.; Villems, RlE. (1979). New efficient route to immobilization of ribonucleic-acids and nucleotides on agarose. Bioorganicheskaya Khimiya, 5 (3), 365−369.
18.04.2019

Jaanus Remme

https://www.etis.ee/CV/Jaanus_Remme/eng
18.12.1953
737 5031
507 1261 (5031)
jaanus.remme@ut.ee
A-4614-2011

Career

Institution and occupation
01.01.2016–31.08.2019   
University of Tartu, Faculty of Science and Technology, Institute of Molecular and Cell Biology, Professor of Molecular Biology (1,00)
1997–...   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Professor (1,00)
1980-1995 ICPB technician, research fellow, senior research fellow
1993-1997 Tartu University, senior research fellow, assistent professor
1997 Tartu University, professor
01.01.2008–31.08.2012   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Head of Chair
01.01.2008–31.12.2015   
University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Professor of Molecular Biology (1,00)
01.09.2007–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Head of Chair
01.09.2007–31.12.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Professor (1,00)
01.09.2006–31.08.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Head
01.09.2002–31.08.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Professor (1,00)
 
 
Education
1972. Tallinn sports boarding school
1980. Tartu University, faculty of Biology and Geography,
biology, genetics
 
 
R&D related managerial and administrative work
2005−...   
2005−2020   
Member of scientific council of IMCB
2005−2015   
2003−2003   
2003, about 1 month, director of IMCB
 
 
Additional career information
;

Qualifications

Academic degrees
Jaanus Remme, Doctor's Degree, 1993, (sup) Richard Villems, Studies of the peptidyltransferase centre of the E. coli ribosome (Studies of the peptidyltransferase centre of the E. coli ribosome), University of Tartu, Faculty of Biology and Geography.
 
 
Honours & awards
2013, Jaanus Remme, National Science Award
2002, Jaanus Remme, White-cross order, 3. class
2000, Jaanus Remme, HHMI International Research Award 2001 - 2005 "Functional Importance of the transient rRNA structures during ribosome large subunit assembly in E. coli
 
 
Field of research
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.1. Biochemistry; SPECIALITY: Protein biosynthesis, RNA biology
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.1. Biochemistry; SPECIALITY: Protein biosynthesis, Ribosome biogenesis, Structure-function of RNA
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.1. Biochemistry; CERCS SPECIALTY: P320 Nucleic acids, protein synthesis ; SPECIALITY: Structure and functions of macromolecules and their complexes involved in biosynthesis of RNA and proteins. Protein biosynthesis, ribosome biogenesis.
 
 
Additional information
doctor of philosophy
Tartu University, 1993

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Lilleorg, Silva; Reier, Kaspar; Pulk, Arto; Liiv, Aivar; Tammsalu, Triin; Peil, Lauri; Cate, JamieH D; Remme, Jaanus (2019). Bacterial ribosome heterogeneity: Changes in ribosomal protein composition during transition into stationary growth phase. Biochimie, 156, 169−180.10.1016/j.biochi.2018.10.013.
1.1.
2019
Kisly, I., Remme, J., Tamm, T. (2019). Ribosomal protein eL24, involved in two intersubunit bridges, stimulates translation initiation and elongation. Nucleic Acids Research, 47 (1), 406−420.10.1093/nar/gky1083.
1.1.
2019
Aleksashin NA, Leppik M, Hockenberry AJ, Klepacki D, Vázquez-Laslop N, Jewett MC, Remme J, Mankin AS. (2019). Assembly and functionality of the ribosome with tethered subunits. Nature Communications, 10 (1), 930.10.1038/s41467-019-08892-w.
1.1.
2019
Ainelo, Andres; Porosk, Rando; Kilk, Kalle; Rosendahl, Sirli; Remme, Jaanus; Horak, Rita (2019). Pseudomonas putida Responds to the Toxin GraT by Inducing Ribosome Biogenesis Factors and Repressing TCA Cycle Enzymes. Toxins, 11 (2), ARTN 103.10.3390/toxins11020103.
1.1.
2018
O’Connor,Michael; Leppik,Margus; Remme, Jaanus (2018). Pseudouridine-Free Escherichia coli Ribosomes. Journal of Bacteriology, 200 (4), e00540-17.10.1128/JB.00540-17.
1.1.
2017
Mets, Toomas; Lippus, Markus; Schryer, David; Liiv, Aivar; Kasari, Villu; Paier, Anton; Maiväli, Ülo; Remme, Jaanus; Tenson, Tanel; Kaldalu, Niilo (2017). Toxins MazF and MqsR cleave Escherichia coli ribosomal RNA precursors at multiple sites. RNA Biology, 14 (1), 124−135.10.1080/15476286.2016.1259784.
1.1.
2017
Lilleorg, Silva; Reier, Kaspar; Remme, Jaanus; Liiv, Aivar (2017). The Intersubunit Bridge B1b of the Bacterial Ribosome Facilitates Initiation of Protein Synthesis and Maintenance of Translational Fidelity. Journal of Molecular Biology, 429 (7), 1067−1080.10.1016/j.jmb.2017.02.015.
1.1.
2017
Leppik, Margus; Liiv, Aivar; Remme, Jaanus (2017). Random pseuoduridylation in vivo reveals critical region of Escherichia coli 23S rRNA for ribosome assembly. Nucleic Acids Research, 45 (10), 6098−6108.10.1093/nar/gkx160.
1.1.
2016
Ainelo, Andres; Tamman, Hedvig; Leppik, Margus; Remme, Jaanus; Hõrak, Rita (2016). The toxin GraT inhibits ribosome biogenesis. Molecular Microbiology, 719−734.10.1111/mmi.13344.
1.1.
2016
Kisly, Ivan; Gulay, Suna P.; Mäeorg, Uno; Dinman, Jonathan D.; Remme, Jaanus; Tamm, Tiina. (2016). The Functional Role of eL19 and eB12 Intersubunit Bridge in the Eukaryotic Ribosome. Journal of Molecular Biology, 428 (10), 2203−2216.10.1016/j.jmb.2016.03.023.
1.1.
2014
Starosta, AL; Lassak, J; Peil, L; Atkinson, GC; Virumäe, K; Tenson, T; Remme, J; Jung, K; Wilson, DN. (2014). Translational stalling at polyproline stretches is modulated by the sequence context upstream of the stall site. Nucleic Acids Research, 42 (16), 10711−10719.10.1093/nar/gku768.
1.1.
2014
Piir, K.; Tamm, T.; Kisly, I.; Tammsalu, T.; Remme, J. (2014). Stepwise Splitting of Ribosomal Proteins from Yeast Ribosomes by LiCl. PLoS ONE, 9 (7), e101561.10.1371/journal.pone.0101561.
1.1.
2014
Starosta, Agata L.; Lassak, Jürgen; Peil, Lauri; Atkinson, Gemma C.; Woolstenhulme, Christopher J.; Virumäe, Kai; Buskirk, Allen; Tenson, Tanel; Remme, Jaanus; Jung, Kirsten; Wilson, Daniel N. (2014). A conserved proline triplet in Val-tRNA synthetase and the origin of elongation factor P. Cell Reports, 9 (2), 476−483.10.1016/j.celrep.2014.09.008.
1.1.
2013
Peil, L.; Starosta, AL.; Lassak, J.; Atkinson, GC; Virumäe, K.; Spitzer, M.; Tenson, T.; Jung, K.; Remme, J.; Wilson, DN. (2013). Distinct XPPX sequence motifs induce ribosome stalling, which is rescued by the translation elongation factor EF-P. Proceedings of the National Academy of Sciences of the United States of America, 110 (38), 15265−15270.10.1073/pnas.1310642110.
1.1.
2013
Samhita, L.; Virumäe, K.; Remme, J.; Varshney, U. (2013). Initiation with elongator tRNAs. Journal of Bacteriology, 195 (18), 4202−4209.10.1128/JB.00637-13.
1.1.
2012
Leppik, M., Ero, R., Liiv, A., Kipper, K., Remme, J. (2012). Different sensitivity of H69 modification enzymes RluD and RlmH to mutations in Escherichia coli 23S rRNA. Biochimie, 94 (5), 1080−1089.
1.1.
2012
Peil, L.; Starosta, A.; Virumäe, K.; Atkinson, G.C.; Tenson, T.; Remme, J.; Wilson, D.N. (2012). Lysine 34 of translation elongation factor EF-P is hydroxylated by YfcM. Nature Chemical Biology, 8 (8), 695−697.10.1038/nchembio.1001.
1.1.
2011
Remme, J. (2011). How to avoid undesirable interactions during ribosome assembly? Molecular Microbiology, 82 (2), 269−271.10.1111/j.1365-2958.2011.07838.x.
1.1.
2011
Siibak, T.; Peil, L.; Dönhofer, A.; Tats, A.; Remm, M.; Wilson, D.; Tenson, T.; Remme, J. (2011). Antibiotic-induced ribosomal assembly defects result from changes in the synthesis of ribosomal proteins. Molecular Microbiology, 80 (1), 54−67.10.1111/j.1365-2958.2011.07555.x.
1.1.
2011
Kipper, K., Sild, S., Hetenyi, C., Remme, J., Liiv, A. (2011). Pseudouridylation of 23S rRNA helix 69 promotes peptide release by release factor RF2 but not by release factor RF1. Biochimie, 93 (5), 834−844.10.1016/j.biochi.2010.12.018.
1.1.
2010
Ero, R.; Leppik, M.; Liiv, A.; Remme, J. (2010). Specificity and kinetics of 23S rRNA modification enzymes RlmH and RluD. RNA-A Publication of the RNA Society, 16 (11), 2075 −2084.10.1261/rna.2234310.
1.1.
2010
Siibak, T.; Remme, J. (2010). Subribosomal particle analysis reveals the stages of bacterial ribosome assembly at which rRNA nucleotides are modified. RNA-A Publication of the RNA Society, 16 (10), 2023−2032.10.1261/rna.2160010.
1.1.
2010
Pulk, A.; Liiv, A.; Peil, L.; Maiväli, Ü.; Nierhaus, K.; Remme, J. (2010). Ribosome reactivation by replacement of damaged proteins. Molecular Microbiology, 75 (4), 801−814.10.1111/j.1365-2958.2009.07002.x.
1.1.
2009
Siibak, T; Peil, L;Xiong, L; Mankin, A;Remme, J;Tenson, T. (2009). Erythromycin- and Chloramphenicol-Induced Ribosomal Assembly Defects Are Secondary Effects of Protein Synthesis Inhibition. Chemotherapy Research and Practice, 53 (2), 563−571.
1.1.
2009
Kipper, K.; Hetényi, C.; Sild, S.; Remme, J.; Liiv, A. (2009). Ribosomal intersubunit bridge B2a is involved in factor-dependent translation initiation and translational processivity. Journal of Molecular Biology, 385 (2), 405−422.10.1016/j.jmb.2008.10.065.
1.1.
2008
Ero, R.; Peil, L.; Liiv, A.; Remme, J. (2008). Identification of pseudouridine methyltransferase in Escherichia coli. RNA-A Publication of the RNA Society, 14 (10), 2223−2233.10.1261/rna.1186608.
1.1.
2008
Peil, L.; Virumäe, K.; Remme, J. (2008). Ribosome assembly in Escherichia coli strains lacking the RNA helicase DeaD/CsdA or DbpA. FEBS Journal, 275 (15), 3772−3782.10.1111/j.1742-4658.2008.06523.x.
1.1.
2007
Leppik, Margus; Peil, Lauri; Kipper, Kalle; Liiv, Aivar; Remme, Jaanus (2007). Substrate specificity of the pseudouridine synthase RluD in Escherichia coli. FEBS Journal, 274 (21), 5759−5766.
6.3.
2007
Maiväli, Ü.; Remme, J. (2007). Elu piirid. Rohtmets, I., Kukk, T. (_EditorsAbbr). Lehed ja tähed IV (78−85).. MTÜ Loodusajakiri.
1.1.
2006
Iskakova, E.; Szaflarski, W.; Dreyfus, M.; Remme, J.; Nierhaus, K. (2006). Troubleshooting coupled in vitro transcription–translation system derived from Escherichia coli cells: synthesis of high-yield fully active proteins. Nucleic Acids Research, 34 (19), e135.
1.1.
2006
Pulk, A; Maiväli, Ü; Remme, J. (2006). Identification of nucleotides in E. coli 16S rRNA essential for ribosome subunit association. RNA-A Publication of the RNA Society, 12 (5), 790−796.
1.1.
2005
Xu, JH.; Golshani, A.; Aoki, H.; Remme, J.; Chosay, J.; Shinabarger, DL.; Ganoza, MC. (2005). Protected nucleotide G2608 in 23S rRNA confers resistance to oxazolidinones in E-coli. Biochemical and Biophysical Research Communications, 328 (2), 471−476.
1.1.
2005
Liiv, A.; Karitkina, D.; Maivali, U.; Remme, J. (2005). Analysis of the function of E-coli 23S rRNA helix-loop 69 by mutagenesis. BMC Molecular Biology, 6, -.
1.1.
2004
Ougland, R.; Zhang, CM.; Liiv, A.; Johansen, RF.; Seeberg, E.; Remme, J.; Falnes, PO. (2004). AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Molecular Cell, 16 (1), 107−116.
1.1.
2004
Liiv, A.; Remme, J. (2004). Importance of transient structures during post-transcriptional refolding of the pre-23 S rRNA and ribosomal large subunit assembly. Journal of Molecular Biology, 342 (3), 725−741.
1.1.
2004
Maiväli, U.; Remme, J. (2004). Definition of bases in 23S rRNA essential for ribosomal subunit association. RNA-A Publication of the RNA Society, 10 (4), 600−604.
1.1.
2003
Allas, U.; Liiv, A.; Remme, J. (2003). Functional interaction between RNase III and the Escherichia coli ribosome. BMC Molecular Biology, 4, -.
1.1.
2002
Virumae, K.; Saarma, U.; Horowitz, J.; Remme, J. (2002). Functional importance of the 3 '-terminal adenosine of tRNA in ribosomal translation. Journal of Biological Chemistry, 277 (27), 24128−24134.
1.1.
2002
Maiväli, Ü.; Pulk, A.; Loogväli, EL.; Remme, J. (2002). Accessibility of phosphates in domain I of 23 S rRNA in the ribosomal 50 S subunit as detected by R-p phosphorothioates. Biochimica et Biophysica Acta - Gene Structure and Expression, 1579 (1), 1−7.
1.1.
2001
Ofengand, J.; Malhotra, A.; Remme, J.; Gutgsell, NS.; Del Campo, M.; Jean-Charles, S.; Peil, L.; Kaya, Y. (2001). Pseudouridines and psendouridine synthases of the ribosome. Cold Spring Harbor Symposia on Quantitative Biology, 66, 147−159.
1.1.
2001
Maivali, U.; Saarma, U.; Remme, J. (2001). Mutations in the Escherichia coli 23S rRNA increase the rate of peptidyl-tRNA dissociation from the ribosome. Molecular Biology, 35 (4), 569−574.
6.3.
1999
Remme, J.; Zobel, K. (1999). Uus aastatuhat ja loodusteaduste lõhenemine. Horisont, 5, 12−15.
1.1.
1998
Saarma, U.; Spahn, CMT.; Nierhaus, KH.; Remme, J. (1998). Mutational analysis of the donor substrate binding site of the ribosomal peptidyltransferase center. RNA-A Publication of the RNA Society, 4 (2), 189−194.
1.1.
1998
Liiv, A.; Remme, J. (1998). Base-pairing of 23 S rRNA ends is essential for ribosomal large subunit assembly. Journal of Molecular Biology, 276 (3), 537−545.
1.1.
1998
Liiv, A.; Tenson, T.; Margus, T.; Remme, J. (1998). Multiple functions of the transcribed spacers in ribosomal RNA operons. Biological Chemistry, 379 (7), 783−793.
1.1.
1997
Saarma, U.; Remme, J.; Ehrenberg, M.; Bilgin, N. (1997). An A to U transversion at position 1067 of 23 S rRNA from Escherichia coli impairs EF-Tu and EF-G function. Journal of Molecular Biology, 272 (3), 327−335.
1.1.
1996
Liiv, A.; Tenson, T.; Remme, J. (1996). Analysis of the ribosome large subunit assembly and 23 S rRNA stability in vivo. Journal of Molecular Biology, 263 (3), 396−410.
1.1.
1996
Spahn, CMT.; Remme, J.; Schafer, MA.; Nierhaus, KH. (1996). Mutational analysis of two highly conserved UGG sequences of 23 S rRNA from Escherichia coli. Journal of Biological Chemistry, 271 (51), 32849−32856.
1.1.
1993
Lewicki, BTU.; Margus, T.; Remme, J.; Nierhaus, KH. (1993). Coupling of ribosomal-RNA transcription and ribosomal assembly invivo - formation of active ribosomal-subunits in escherichia-coli requires transcription of ribosomal-RNA genes by host RNA- polymerase which cannot be replaced by bacteriophage-t7 RNA- polyme. Journal of Molecular Biology, 231 (3), 581−593.
3.1.
1993
Saarma, U.; Lewicki, BTU.; Margus, T.; Nigul, S.; Remme, J. (1993). Analysis of mutations in the 23S rRNA. Nierhaus, K.H.; Franchesci, F.; Subramanian, A.R.; Erdmann, V.A.; Wittmann-Liebold, B.. The Translational Apparatus: structure, function, regulation, evolution (445−454).. New York: Plenum Press.
1.1.
1992
Saarma, U.; Remme, J. (1992). Novel mutants of 23s RNA - characterization of functional-properties. Nucleic Acids Research, 20 (12), 3147−3152.
3.1.
1990
Rheinberger, H.-J.; Geigenmüller, U.; Gnirke, A.; Hausner, T.-P.; Remme, J.; Saruyama, H.; Nierhaus, K. H. (1990). Allosteric three-site model for the ribosomal elongation cycle. The Ribosomes, Structure, Function and Genetics. _EditorsAbbr Hill, W.E.; Dahlberg, A.; Garrett, R.A.; Moore, P.B.; Schlessinger, D.; Warner, J.R. Washington, D.C.: American Society of Microbiology, 318−330.
1.1.
1989
Remme, J.; Margus, T.; Villems, R.; Nierhaus, KH. (1989). The 3rd ribosomal transfer RNA- binding site, the e-site, is occupied in native polysomes. European Journal of Biochemistry, 183 (2), 281−284.
1.1.
1986
Iusupova, GZ.; Remme, JL.; Belitsina, NV.; Spirin, AS. (1986). Template-free ribosomal synthesis of polylysine from individual lysyl-transfer RNA lys. Doklady Akademii Nauk SSSR, 289 (3), 725−728.
1.1.
1985
Maimets, T.O.; Remme, J. L.; Villems, R. L.-E. (1985). Stimulation of 50S subparticle peptidyl transferase activity of with alcohols. Molecular Biology, 19 (3), 510−515.
1.1.
1985
Remme, J.; Villems, R. (1985). On the physicochemical rationale of the genetic-code. FEBS Letters, 189 (2), 159−162.
1.1.
1985
Maimets, TO.; Remme, YL.; Villems, RlE. (1985). Stimulation of 50s-subparticle peptidyl transferase-activity with alcohols. Molecular Biology, 19 (3), 510−515.
1.1.
1985
Remme, J.; Metspalu, E.; Maimets, T.; Villems, R. (1985). The properties of the complex between ribosomal protein-l2 and transfer-rna. FEBS Letters, 190 (2), 275−278.
1.1.
1984
Maimets, T. O.; Ustav, M. B.; Remme, J. L.; Villems, R. L.-E. (1984). The L16 protein of the escherichia-coli ribosome: its possible role in protein biosynthesis. Molecular Biology, 18 (6), 1305−1313.
1.1.
1984
Maimets, T.; Remme, J.; Villems, R. (1984). Ribosomal protein L16 binds to the 3'-end of transfer-rna. FEBS Letters, 166 (1), 53−56.
1.1.
1984
Maimets, TO.; Ustav, MB.; Remme, YL.; Villems, RlE. (1984). The l16 protein of the escherichia-coli ribosome - possible role in protein-biosynthesis. Molecular Biology, 18 (6), 1305−1313.
1.1.
1983
Remme, J.; Maimets, T.; Ustav, M.; Villems, R. (1983). The interaction of ribosomal protein-l16 and its fragments with transfer-rna. FEBS Letters, 153 (2), 267−269.
1.1.
1979
Ustav, MB.; Remme, JL.; Lind, AJ.; Villems, RlE. (1979). New efficient route to immobilization of ribonucleic-acids and nucleotides on agarose. Bioorganicheskaya Khimiya, 5 (3), 365−369.
18.04.2019
Detailne otsing
  • Leitud 10 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
SFSF0182550As03Makromolekulide biosüntees ja degradatsioon01.01.200331.12.2007Jaanus RemmeEesti Biokeskus142 523,00 EUR
SFSF_0182550As03Makromolekulide biosüntees ja degradatsioon01.01.200331.12.2007Jaanus RemmeEesti Biokeskus0,00 EUR
SFSF0182550Bs03Makromolekulide biosüntees ja degradatsioon01.01.200331.12.2007Jaanus RemmeTartu Ülikool, Bioloogia-geograafiateaduskond250 917,13 EUR
IUTIUT20-21Makromolekulide biosüntees ja selle masinavärgi funktsiooni säilitamine01.01.201431.12.2019Jaanus RemmeTartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut1 203 000,00 EUR
SFSF0180164s08Makromolekulide biosünteesi mehhanismid01.01.200831.12.2013Jaanus RemmeTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut705 840,56 EUR
ETFETF5822Modifitseeritud nukleosiidide roll ribosoomides01.01.200431.12.2007Jaanus RemmeTartu Ülikool, Bioloogia-geograafiateaduskond46 677,01 EUR
ETFETF7509Ribosomaalse RNA modifitseeritud nukleosiidide ja modifikatsiooniensüümide funktsioon01.01.200831.12.2011Jaanus RemmeTartu Ülikool, Bioloogia-geograafiateaduskond; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond80 047,58 EUR
ETFETF9289Ribosoomide reparatsioon01.01.201231.12.2015Jaanus RemmeTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut69 600,00 EUR
APSF0180164s08AP12Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180164s08 raames01.03.201231.12.2012Jaanus RemmeTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut64 000,00 EUR
APSF0180164s08APVäikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180164s08 raames01.01.201031.12.2011Jaanus RemmeTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut63 911,65 EUR