See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Krista Fischer

https://www.etis.ee/CV/Krista_Fischer/est
5.08.1970
515 3679 (4446)
krista.fischer@ut.ee

Teenistuskäik

Töökohad ja ametid
01.01.2021–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, genoomika instituut, biostatistika kaasprofessor (0,20)
01.09.2018–...   
Tartu Ülikool, Loodus- ja täppisteaduste valdkond, matemaatika ja statistika instituut, matemaatilise statistika professor (0,80)
01.09.2018–31.12.2020   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, biostatistika vanemteadur (0,20)
01.01.2018–31.08.2018   
Tartu Ülikool, Tartu Ülikooli genoomika instituut, biostatistika vanemteadur (1,00)
01.02.2016–31.12.2017   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, biostatistika vanemteadur (1,00)
01.01.2016–31.01.2016   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, biostatistika peaspetsialist (1,00)
01.01.2013–31.12.2015   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, vanemteadur (1,00)
01.06.2010–31.12.2012   
Tartu Ülikool, Tartu Ülikooli Eesti Geenivaramu, genoomika vanemteadur (1,00)
01.01.2007–31.12.2010   
MRC (Medical Research Council) Biostatistika osakond, Cambridge, UK
01.09.2006–31.08.2009   
Tartu Ülikool, Arstiteaduskond, Tervishoiu instituut, biostatistika erakorraline dotsent (1,00)
01.09.2001–31.08.2006   
Tartu Ülikool, Arstiteaduskond, Tervishoiu instituut, biostatistika dotsent (1,00)
01.01.1999–31.12.2001   
teadur (järeldoktorantuuris), Genti ülikool, Belgia
1994–2000   
Tartu Ülikool, Matemaatika-informaatikateaduskond, Matemaatilise statistika instituut, Matemaatilise statistika õppetool, Teadur (1,00)
 
 
Haridustee
1994–1999   
doktoriõpe TÜ matemaatikateaduskonnas, matemaatilise statistika instituudi juures, spetsialiseerumine matemaatilise statistika erialal
1992–1994   
magistriõpe Belgias Limburgi ülikoolis programmi "Master of Science in Biostatistics" raames
1988–1992   
diplomiõpe Tartu Ülikooli matemaatikateaduskonnas rakendusmatemaatika erialal
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2020−...   
Tartu Ülikooli Senati liige
2015−...   
International Biometric Society: Member of the Executive Board
2002−...   
Rahvusvahelise kursuse "Statistical Practice in Epidemiology using R" (Tartu Ülikool, Tartu, IARC, Lyon) organiseerija.
2020−2020   
Konverentsi "41th Annual Conference of the International Society for Clinical Biostatistics" programmikomitee liige.
2017−2018   
Konverentsi "Nordstat 2018" kohaliku orgkomitee esimees ja programmikomitee liige
2016−2017   
Konverentsi "European Mathematical Genetics Meeting 2017" kohaliku orgkomitee juht
2013−2016   
Rahvusvahelise biomeetriaühingu "International Biometric Society" Põhja-Balti regiooni president
2011−2011   
Konverentsi "3rd Nordic-Baltic Biometric Conference" (Turu, Soome, 6.-9. juuni 2011) teadusliku programmikomitee esimees
2011−2014   
Rahvusvahelise biomeetriaühingu "International Biometric Society" hariduskomitee juhataja.
2009−2009   
Konverentsi "2nd Nordic-Baltic Biometric Conference" kohaliku orgkomitee esimees ja programmikomitee liige
2003−2005   
Järgmiste rahvusvaheliste konverentside teadusliku programmikomitee liige: "The 7th Tartu Conference on Multivariate Statistics (Tartu, 2003)", "26th Annual Conference of International Society for Clinical Biostatistics" (Szeged, 2005)
2002−2010   
Rahvusvahelise biomeetriaühingu "International Biometric Society" Balti grupi juhataja ja asutajaliige

Kvalifikatsioon

Teaduskraadid
Krista Fischer, doktorikraad, 1999, (juh) Els Goetghebeur; Tõnu Kollo, Structural Mean Models for Analyzing the Effect of Compliance in Clinical Trials, Tartu Ülikool, Matemaatika-informaatikateaduskond.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.11. Terviseuuringutega seotud uuringud, näiteks biokeemia, geneetika, mikrobioloogia, biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika ja bioinformaatika; TÄPSUSTUS: biostatistika, statistilised meetodid epidemioloogias ja kliinilistes uuringutes
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS KLASSIFIKAATOR: B110 Bioinformaatika, meditsiiniinformaatika, biomatemaatika, biomeetrika ; TÄPSUSTUS: Statistiline geneetika, geneetiline epidemioloogia
 
 
Lisainfo
filosoofiadoktor (Ph.D.) matemaatilise statistika erialal
teadusmagister (MSc) biostatistika erialal
Tartu Ülikool, 1999

Limburgi ülikool, Belgia, 1994

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2022
Macdonald-Dunlop, Erin; Taba, Nele; Klarić, Lucija; Frkatović, Azra; Walker, Rosie; Hayward, Caroline; Esko, Tõnu; Haley, Chris; Fischer, Krista; Wilson, James F.; Joshi, Peter K. (2022). A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk. Aging, 623−659. DOI: 10.18632/aging.203847.
1.1.
2022
Uusküla, A.; Kalda, R.; Solvak, M.; Jürisson, M.; Käärik, M.; Fischer, K.; Keis, A.; Raudvere, U.; Vilo, J.; Peterson, H.; Käärik, E.; Metspalu, M.; Jürgenson, T.; Milani, L.; Kolberg, L.; Tiit, E.-M.; Vassil, K. (2022). The 1st year of the COVID-19 epidemic in Estonia: a population-based nationwide sequential/consecutive cross-sectional study. Public Health, 205, 150−156. DOI: 10.1016/j.puhe.2022.02.004.
1.1.
2021
Barahona Ponce, Carol; Scherer, Dominique; Brinster, Regina; Boekstegers, Felix; Marcelain, Katherine; Gárate, Valentina; Müller, Bettina; de Toro, Gonzalo; Retamales, Javier; Barajas, Olga; Ahumada, Monica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo ... Lorenzo Bermejo, Justo (2021). Gallstones, Body Mass Index, C‐reactive Protein and Gallbladder Cancer – Mendelian Randomization Analysis of Chilean and European Genotype Data. Hepatology, 73 (5), 1783−1796. DOI: 10.1002/hep.31537.
1.1.
2021
Prins, Bram Peter; Leitsalu, Liis; Pärna, Katri; Fischer, Krista; Metspalu, Andres; Haller, Toomas; Snieder, Harold (2021). Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example. Journal of Personalized Medicine, 11 (5). DOI: 10.3390/jpm11050358.
1.1.
2021
Ojavee, Sven E.; Kousathanas, Athanasios; Trejo Banos, Daniel; Orliac, Etienne J.; Patxot, Marion; Laell, Kristi; Maegi, Reedik; Fischer, Krista; Kutalik, Zoltan; Robinson, Matthew R. (2021). Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. Nature Communications, 12 (1), ARTN 2337. DOI: 10.1038/s41467-021-22538-w.
1.1.
2021
Reintam Blaser, Annika; Padar, Martin; Mändul, Merli; Elke, Gunnar; Engel, Christoph; Fischer, Krista; Giabicani, Mikhael; Gold, Thomas; Hess, Benjamin; Hiesmayr, Michael; Jakob, Stephan M.; Loudet, Cecilia I.; Meesters, Dennis M.; Mongkolpun, Wasineenart; Paugam-Burtz, Catherine; Poeze, Martijn; Preiser, Jean-Charles; Renberg, Mattias; Rooijackers, Olav; Tamme, Kadri ... Starkopf, Joel (2021). Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients – A prospective multicenter observational study (iSOFA study). Clinical Nutrition, 40 (8), 4932−4940. DOI: 10.1016/j.clnu.2021.07.015.
1.1.
2021
Vojinovic, Dina; Kalaoja, Marita; Trompet, Stella; Fischer, Krista; Shipley, Martin J.; Li, Shuo; Havulinna, Aki S.; Perola, Markus; Salomaa, Veikko; Yang, Qiong; Sattar, Naveed; Jousilahti, Pekka; Amin, Najaf; Satizabal, Claudia L.; Taba, Nele; Sabayan, Behnam; Vasan, Ramachandran S.; Ikram, M. Arfan; Stott, David J.; Ala-Korpela, Mika ... van Duijn, Cornelia M. (2021). Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke. Neurology, 96 (8), e1110−e1123. DOI: 10.1212/WNL.0000000000011236.
1.1.
2021
Munn-Chernoff, Melissa A.; Johnson, Emma C.; Chou, Yi-Ling; Coleman, Jonathan R. I.; Thornton, Laura M.; Walters, Raymond K.; Yilmaz, Zeynep; Baker, Jessica H.; Hubel, Christopher; Gordon, Scott; Medland, Sarah E.; Watson, Hunna J.; Gaspar, Helena A.; Bryois, Julien; Hinney, Anke; Leppa, Virpi M.; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodriguez, Paola ... Agrawal, Arpana (2021). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, 26 (1), ARTN e12880. DOI: 10.1111/adb.12880.
1.1.
2021
Iurilli, Maria L. C.; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino; Chirita-Emandi, Adela; Hayes, Alison J.; Ikeda, Nayu ... Filippi, Sarah (2021). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC). eLife, 10 (e60060), ARTN e60060. DOI: 10.7554/eLife.60060.
1.1.
2021
Taba, Nele; Valge, Hanna-Kristel; Metspalu, Andres; Esko, Tonu; Wilson, James F.; Fischer, Krista; Pirastu, Nicola (2021). Mendelian Randomization Identifies the Potential Causal Impact of Dietary Patterns on Circulating Blood Metabolites. Frontiers in Genetics, 12, ARTN 738265. DOI: 10.3389/fgene.2021.738265.
1.1.
2021
Aasmets, Oliver; Lull, Kreete; Lang, Jennifer M.; Pan, Calvin; Kuusisto, Johanna; Fischer, Krista; Laakso, Markku; Lusis, Aldons J.; Org, Elin (2021). Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation. mSystems, 6 (1), ARTN e01191-20. DOI: 10.1128/mSystems.01191-20.
1.1.
2020
Saar, Aet; Läll, Kristi; Alver, Maris; Marandi, Toomas; Ainla, Tiia; Eha, Jaan; Metspalu, Andres; Fischer, Krista (2020). Estimating the performance of three cardiovascular disease risk scores: the Estonian Biobank cohort study. Journal of Epidemiology & Community Health, 73 (3). DOI: 10.1136/jech-2017-209965.
1.1.
2020
Munn-Chernoff, Melissa A; Johnson, Emma C; Chou, Yi-Ling; Coleman, Jonathan R I; Thornton, Laura M; Walters, Raymond K; Yilmaz, Zeynep; Baker, Jessica H; Hübel, Christopher; Gordon, Scott; Medland, Sarah E; Watson, Hunna J; Gaspar, Héléna A; Bryois, Julien; Hinney, Anke; Leppä, Virpi M; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola ... Agrawal, Arpana (2020). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, e12880−e12880. DOI: 10.1111/adb.12880.
1.1.
2020
Klarić, Lucija; Tsepilov, Yakov A; Stanton, Chloe M; Mangino, Massimo; Sikka, Timo Tõnis; Esko, Tõnu; Pakhomov, Eugene; Salo, Perttu; Deelen, Joris; McGurnaghan, Stuart J; Keser, Toma; Vučković, Frano; Ugrina, Ivo; Krištić, Jasminka; Gudelj, Ivan; Štambuk, Jerko; Plomp, Rosina; Pučić-Baković, Maja; Pavić, Tamara; Vilaj, Marija ... Hayward, Caroline (2020). Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Science Advances, 6 (8), eaax0301−eaax0301. DOI: 10.1126/sciadv.aax0301.
1.1.
2020
Bryois, Julien; Skene, Nathan G.; Hansen, Thomas Folkmann; Kogelman, Lisette J. A.; Watson, Hunna J.; Liu, Zijing; Brueggeman, Leo; Breen, Gerome; Bulik, Cynthia M.; Arenas, Ernest; Hjerling-Leffler, Jens; Sullivan, Patrick F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. Nature Genetics, 52 (5), 482−+. DOI: 10.1038/s41588-020-0610-9.
1.1.
2020
Marnetto, Davide; Pärna, Katri; Läll, Kristi; Molinaro, Ludovica; Montinaro, Francesco; Haller, Toomas; Metspalu, Mait; Mägi, Reedik; Fischer, Krista; Pagani, Luca (2020). Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals. Nature Communications, 11 (1), 1628−1628. DOI: 10.1038/s41467-020-15464-w.
1.1.
2020
Hsu, Yu-Han H.; Astley, Christina M.; Cole, Joanne B.; Vedantam, Sailaja; Mercader, Josep M.; Metspalu, Andres; Fischer, Krista; Fortney, Kristen; Morgen, Eric K.; Gonzalez, Clicerio; Gonzalez, Maria E.; Esko, Tonu; Hirschhorn, Joel N. (2020). Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome. International Journal of Obesity, 44 (7), 1596−1606. DOI: 10.1038/s41366-020-0603-x.
1.1.
2020
Parna, Katri; Snieder, Harold; Lall, Kristi; Fischer, Krista; Nolte, Ilja (2020). Validating the doubly weighted genetic risk score for the prediction of type 2 diabetes in the Lifelines and Estonian Biobank cohorts. Genetic Epidemiology, 44 (6), 589−600. DOI: 10.1002/gepi.22327.
1.1.
2020
Tillmann, Taavi; Läll, Kristi; Dukes, Oliver; Veronesi, Giovanni; Pikhart, Hynek; Peasey, Anne; Kubinova, Ruzena; Kozela, Magdalena; Pajak, Andrzej; Nikitin, Yuri; Malyutina, Sofia; Metspalu, Andres; Esko, Tõnu; Fischer, Krista; Kivimäki, Mika; Bobak, Martin (2020). Development and validation of two SCORE-based cardiovascular risk prediction models for Eastern Europe: a multicohort study. European Heart Journal, 41 (35), 3325−3333. DOI: 10.1093/eurheartj/ehaa571.
1.1.
2020
Rodriguez-Martinez, Andrea; Zhou, Bin; Sophiea, Marisa K; Bentham, James; Paciorek, Christopher J; Iurilli, Maria LC; Carrillo-Larco, Rodrigo M; Bennett, James E; Di Cesare, Mariachiara; Taddei, Cristina; Bixby, Honor; Stevens, Gretchen A; Riley, Leanne M; Cowan, Melanie J; Savin, Stefan; Danaei, Goodarz; Chirita-Emandi, Adela; Kengne, Andre P; Khang, Young-Ho; Laxmaiah, Avula ... Ezzati, Majid (2020). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. The Lancet, 396 (10261), 1511−1524. DOI: 10.1016/S0140-6736(20)31859-6.
5.1.
2020
Taba, N.; Fischer, K.; Esko, T.; Metspalu, A.; Pirastu, N. (2020). Causal Relationships between Dietary Items and Blood Metabolites Using Mendelian Randomization. Human Heredity, 84 (4-5), 225−226.
6.8.
2020
Ponce, Carol Barahona; Scherer, Dominique; Boekstegers, Felix; Garate-Calderon, Valentina; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Bonet, Catalina; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Schoettker, Ben; Holleczek, Bernd; Hveem, Kristian; Eklund, Niina; Voelker, Uwe; Waldenberger, Melanie; Bermejo, Justo Lorenzo (2020). Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data. International Journal of Cancer, 146 (9), 2648−2650. DOI: 10.1002/ijc.32837.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, 12 (5), 1050−1061. DOI: 10.1111/eva.12780.
1.1.
2019
Timmers, Paul Rhj; Mounier, Ninon; Lall, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew D; Clark, David W; ,; Agbessi, M; Ahsan, H; Alves, I; Andiappan, A; Awadalla, P; Battle, A; Bonder, M J; Boomsma, D; Christiansen, M; Claringbould, A; Deelen, P ... Joshi, Peter K (2019). Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife, 8, e39856. DOI: 10.7554/eLife.39856.
1.1.
2019
Läll, Kristi; Lepamets, Maarja; Palover, Marili; Esko, Tõnu; Metspalu, Andres; Tõnisson, Neeme; Padrik, Peeter; Mägi, Reedik; Fischer, Krista (2019). Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification. BMC Cancer, 19 (1), ARTN 557. DOI: 10.1186/s12885-019-5783-1.
1.1.
2019
Sarin, Heikki V; Taba, Nele; Fischer, Krista; Esko, Tonu; Kanerva, Noora; Moilanen, Leena; Saltevo, Juha; Joensuu, Anni; Borodulin, Katja; Männistö, Satu; Kristiansson, Kati; Perola, Markus (2019). Food neophobia associates with poorer dietary quality, metabolic risk factors, and increased disease outcome risk in population-based cohorts in a metabolomics study. American Journal of Clinical Nutrition, 110 (1), 233−245. DOI: 10.1093/ajcn/nqz100.
1.1.
2019
Bixby, Honor; Bentham, James; Zhou, Bin; Di Cesare, Mariachiara; Paciorek, Christopher J.; Bennett, James E.; Taddei, Cristina; Stevens, Gretchen A.; Rodriguez-Martinez, Andrea; Carrillo-Larco, Rodrigo M.; Khang, Young-Ho; Soric, Maroje; Gregg, Edward W.; Miranda, J. Jaime; Bhutta, Zulfiqar A.; Savin, Stefan; Sophiea, Marisa K.; Iurilli, Maria L. C.; Solomon, Bethlehem D.; Cowan, Melanie J. ... Ezzati, Majid (2019). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature, 569 (7755), 260−281. DOI: 10.1038/s41586-019-1171-x.
1.1.
2019
van der Lee, Sven J.; Teunissen, Charlotte E.; Pool, Rene; Shipley, Martin J.; Teumer, Alexander; Chouraki, Vincent; van Lent, Debora Melo; Tynkkynen, Juho; Fischer, Krista; Hernesniemi, Jussi; Haller, Toomas; Singh-Manoux, Archana; Verhoeven, Aswin; Willemsen, Gonneke; de Leeuw, Francisca A.; Wagner, Holger; van Dongen, Jenny; Hertel, Johannes; Budde, Kathrin; van Dijk, Ko Willems ... van Duijn, Cornelia M. (2019). Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies (vol 14, pg 707, 2018). In: (319−319). NEW YORK: ELSEVIER SCIENCE INC. (15). DOI: 10.1016/j.jalz.2019.01.002.
1.1.
2019
Hsu, Yu-Han H; Churchhouse, Claire; Pers, Tune H; Mercader, Josep M; Metspalu, Andres; Fischer, Krista; Fortney, Kristen; Morgen, Eric K; Gonzalez, Clicerio; Gonzalez, Maria E; Esko, Tonu; Hirschhorn, Joel N (2019). PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data. PLoS Computational Biology, 15 (1), e1006734−e1006734. DOI: 10.1371/journal.pcbi.1006734.
1.1.
2019
Deelen, Joris; Kettunen, Johannes; Fischer, Krista; van der Spek, Ashley; Trompet, Stella; Kastenmueller, Gabi; Boyd, Andy; Zierer, Jonas; van den Akker, Erik B.; Ala-Korpela, Mika; Amin, Najaf; Demirkan, Ayse; Ghanbari, Mohsen; van Heemst, Diana; Ikram, M. Arfan; van Klinken, Jan Bert; Mooijaart, Simon P.; Peters, Annette; Salomaa, Veikko; Sattar, Naveed ... Slagboom, P. Eline (2019). A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals. Nature Communications, 10, ARTN 3346. DOI: 10.1038/s41467-019-11311-9.
1.1.
2019
Ho, Andrew; Sinick, Jonah; Esko, Tonu; Fischer, Krista; Menni, Cristina; Zierer, Jonas; Matey-Hernandez, Maria; Fortney, Kristen; Morgen, Eric K. (2019). Circulating glucuronic acid predicts healthspan and longevity in humans and mice. Aging, 11 (18), 7694−7706. DOI: 10.18632/aging.102281.
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F.; Feufer, Arne P.; Marullo, Letizia; Magi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in Medicine, 13 (11), 931−940. DOI: 10.2217/bmm-2017-0431.
1.1.
2019
van der Spek, Ashley; Broer, Linda; Draisma, Harmen H. M.; Pool, Rene; Albrecht, Eva; Beekman, Marian; Mangino, Massimo; Raag, Mait; Nyholt, Dale R.; Dharuri, Harish K.; Codd, Veryan; Amin, Najaf; de Geus, Eco J. C.; Deelen, Joris; Demirkan, Ayse; Yet, Idil; Fischer, Krista; Haller, Toomas; Henders, Anjali K.; Isaacs, Aaron ... Gieger, Christian (2019). Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium. Scientific Reports, 9 (1), 1162323. DOI: 10.1038/s41598-019-47282-6.
1.1.
2019
Clark, David W.; Okada, Yukinori; Moore, Kristjan H. S.; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L. K.; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M. ... Wilson, James F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, ARTN 4957. DOI: 10.1038/s41467-019-12283-6.
1.1.
2019
Yao, Shuyang; Kuja-Halkola, Ralf; Martin, Joanna; Lu, Yi; Lichtenstein, Paul; Norring, Claes; Birgegard, Andreas; Yilmaz, Zeynep; Hubel, Christopher; Watson, Hunna; Baker, Jessica; Almqvist, Catarina; Thornton, Laura M.; Magnusson, Patrik K.; Bulik, Cynthia M.; Larsson, Henrik; Adan, Roger; Ando, Tetsuya; Bergen, Andrew; Berrettini, Wade ... Bulik, Cynthia (2019). Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry, 86 (8), 577−586. DOI: 10.1016/j.biopsych.2019.04.036.
1.1.
2019
Watson, Hunna J.; Yilmaz, Zeynep; Thorntont, Laura M.; Hubel, Christopher; Coleman, Jonathan R., I; Gaspar, Helena A.; Bryois, Julien; Hinney, Anke; Leppa, Virpi M.; Mattheisen, Manuel; Medland, Sarah E.; Ripke, Stephan; Yao, Shuyang; Giusti-Rodriguez, Paola; Hanscombe, Ken B.; Purves, Kirstin L.; Adan, Roger A. H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A. ... Bulik, Cynthia M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51 (8), 1207−+. DOI: 10.1038/s41588-019-0439-2.
1.3.
2019
Laas, Karin; Teär, Carmen Marianne; Pehme, Lea; Viiklepp, Piret; Fischer, Krista; Tammaru, Marika (2019). Reumatoidartriidi patsientide haigestumus tuberkuloosi enne ja pärast bioloogilise ravi kasutuselevõttu Eestis: kahe perioodi võrdlus. Eesti Arst.
5.1.
2019
Tõnisson, Neeme; Roht; Laura; Palover, Marili; Leitsalu, Liis; Läll, Kristi; Fischer; Kruuv-Käo, Krista; Eelma, Evelyn; Lehtsaar, Jaak; Jürgens, Hannes; Kütner, Riina; Valvere, Vahur; Nikopensius, Tiit; Reigo, Anu: Tammesoo, Mari-Liis; Esko, Tõnu; Metspalu, Andres; Padrik, Peeter (2019). Genotype first female breast cancer risk-based screening and management, initial lessons from a national pilot project. European Journal of Human Genetics, 10: European Human Genetics Conference, 15–18 juuni, 2019. Nature Research. (SUPPLEMENT).
1.1.
2018
Saar, Aet; Marandi, Toomas; Ainla, Tiia; Fischer, Krista; Blöndal, Mai; Eha, Jaan (2018). The risk-treatment paradox in non-ST-elevation myocardial infarction patients according to their estimated GRACE risk. International Journal of Cardiology, 272, 26−32. DOI: 10.1016/j.ijcard.2018.08.015.
1.1.
2018
Tynkkynen J., Chouraki V., van der Lee S.J, Hernesniemi J., Yang, Q., Li, S., Beiser, A., Larson, M.G., Sääksjärvi, K., Shipley, M.,J., Singh-Manoux, A., Gerszten, R.E., Wang T.J., Havulinna A.S., Würtz P., Fischer K., Demirkan A., Ikram M.A., Amin N., Lehtimäki T, Kähönen M., Perola M., Metspalu A., Kangas A., Soininen P., Ala-Korpela M., Vasan R.S., Kivimäki M., van Duijn C.M, Seshadri S., Salomaa V. (2018). Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimer's & Dementia, 723−733. DOI: 10.1016/j.jalz.2018.01.003.
1.1.
2018
Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516. DOI: 10.1038/s41588-018-0241-6.
1.1.
2018
van der Lee, Sven J.; Teunissen, Charlotte E.; Pool, Rene; Shipley, Martin J.; Teumer, Alexander; Chouraki, Vincent; van Lent, Debora Melo; Tynkkynen, Juho; Fischer, Krista; Hernesniemi, Jussi; Haller, Toomas; Singh-Manoux, Archana; Verhoeven, Aswin; Willemsen, Gonneke; de Leeuw, Francisca A.; Wagner, Holger; van Dongen, Jenny; Hertel, Johannes; Budde, Kathrin; van Dijk, Ko Willems ... van Duijn, Cornelia M. (2018). Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimer's & Dementia, 14 (6), 707−722. DOI: 10.1016/j.jalz.2017.11.012.
1.1.
2018
Parmar, Priyanka; Lowry, Estelle; Cugliari, Giovanni; Suderman, Matthew; Wilson, Rory; Karhunen, Ville; Andrew, Toby; Wiklund, Petri; Wielscher, Matthias; Guarrera, Simonetta; Teumer, Alexander; Lehne, Benjamin; Milani, Lili; de Klein, Niek; Mishra, Pashupati P.; Melton, Phillip E.; Mandaviya, Pooja R.; Kasela, Silva; Nano, Jana; Zhang, Weihua ... Sebert, Sylvain (2018). Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults. EBioMedicine, 38, 206−216. DOI: 10.1016/j.ebiom.2018.10.066.
1.1.
2018
Ligthart, Symen; Vaez, Ahmad; Võsa, Urmo; Stathopoulou, Maria G; de Vries, Paul S; Prins, Bram P; Van der Most, Peter J; Tanaka, Toshiko; Naderi, Elnaz; Rose, Lynda M; Wu, Ying; Karlsson, Robert; Barbalic, Maja; Lin, Honghuang; Pool, René; Zhu, Gu; Macé, Aurélien; Sidore, Carlo; Trompet, Stella; Mangino, Massimo ... Alizadeh, Behrooz Z (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. The American Journal of Human Genetics, 103 (5), 691−706. DOI: 10.1016/j.ajhg.2018.09.009.
1.1.
2018
Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571. DOI: 10.1038/s41588-018-0084-1.
1.1.
2018
Zhou, Bin; Bentham, James; Di Cesare, Mariachiara; Bixby, Honor; Danaei, Goodarz; Hajifathalian, Kaveh; Taddei, Cristina; Carrillo-Larco, Rodrigo M.; Djalalinia, Shirin; Khatibzadeh, Shahab; Lugero, Charles; Peykari, Niloofar; Zhang, Wan Zhu; Bennett, James; Bilano, Ver; Stevens, Gretchen A.; Cowan, Melanie J.; Riley, Leanne M.; Chen, Zhengming; Hambleton, Ian R. ... Cisneros, Julio Zuniga (2018). Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. International Journal of Epidemiology, 47 (3), 872−893. DOI: 10.1093/ije/dyy016.
5.2.
2018
Saar, A; Marandi, T; Ainla, T; Fischer, K; Blöndal, M, Eha, J (2018). The treatment and mortality of patients with non-ST-segment elevation myocardial infarction according to estimated risk - real world data from Estonian Myocardial Infarction Registry. European Heart Journal: Acute Cardiovascular Care: Acute Cardiovascular Care 2018, Milano. Sage Publications Ltd.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110. DOI: 10.1186/s12859-017-1530-2.
1.1.
2017
Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25. DOI: 10.1186/s12859-016-1437-3.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences, 114 (3), E327−E336. DOI: 10.1073/pnas.1619052114.
1.1.
2017
Haller, Toomas; Leitsalu, Liis; Fischer, Krista; Nuotio, Marja-Liisa; Esko, Tonu; Boomsma, Dorothea Irene; Kyvik, Kirsten Ohm; Spector, Tim D.; Perola, Markus; Metspalu, Andres (2017). MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies. PLoS ONE, 12 (1), ARTN e0170325. DOI: 10.1371/journal.pone.0170325.
1.1.
2017
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201. DOI: 10.1038/mp.2016.71.
1.1.
2017
Wahl, Simone; Drong, Alexander; Lehne, Benjamin; Loh, Marie; Scott, William R; Kunze, Sonja; Tsai, Pei-Chien; Ried, Janina S; Zhang, Weihua; Yang, Youwen; Tan, Sili; Fiorito, Giovanni; Franke, Lude; Guarrera, Simonetta; Kasela, Silva; Kriebel, Jennifer; Richmond, Rebecca C; Adamo, Marco; Afzal, Uzma; Ala-Korpela, Mika ... Chambers, John C (2017). Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541 (7635), 81−86. DOI: 10.1038/nature20784.
1.1.
2017
Reisberg, Sulev; Iljasenko, Tatjana; Läll, Kristi; Fischer, Krista; Vilo, Jaak (2017). Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations. PLoS ONE, 12 (7), e0179238−e0179238. DOI: 10.1371/journal.pone.0179238.
1.1.
2017
Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genetics, 13 (6), e1006812. DOI: 10.1371/journal.pgen.1006812.
1.1.
2017
Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark D.W., Nutile T., Barnes C.L.K., Timmers P.R.H.J., Shen X., Gandin I., McDaid A.F., Hansen T.F., Gordon S.D., Giulianini F., Boutin T.S., Abdellaoui A., Zhao W., Medina-Gomez C., Bartz T.M., Trompet S., Lange L.A., Raffield L., van der Spek A.,/.../,Bertram L., Pendleton N., Kardia S.L.R., Ciullo M., Becker D.M., Wong A., Psaty B.M., van Duijn C.M., Wilson J.G., Jukema J.W., Kiemeney L., Uitterlinden A.G, Franceschini N., North K.E., Weir D.R., Metspalu A., Boomsma D.I., Hayward C., Chasman D., Martin N.G., Sattar N., Campbell H., Esko T., Kutalik Z., Wilson J.F. (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, 910. DOI: 10.1038/s41467-017-00934-5.
1.1.
2017
Kõks G, Fischer K, Kõks S. (2017). Smoking-related general and cause-specific mortality in Estonia. BMC Public Health, 18 (1), 34. DOI: 10.1186/s12889-017-4590-3.
1.1.
2017
Tillmann T., Vaucher J., Okbay A., Pikhart H., Peasey A., Kubinova R., Pajak A., Tamosiunas A, Malyutina S., Hartwig F.P., Fischer K., Veronesi G., Palmer T., Bowden J., Davey Smith G., Bobak M., Holmes M.V. (2017). Education and coronary heart disease: mendelian randomisation study. British Medical Journal, 358, j3542. DOI: 10.1136/bmj.j3542.
1.1.
2017
Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltan; Xue, Luting; Mahajan, Anubha ... Cupples, L. Adrienne (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (14977), ARTN 14977. DOI: 10.1038/ncomms14977.
1.1.
2017
Kasela, Silva; Kisand, Kai; Tserel, Liina; Kaleviste, Epp; Remm, Anu; Fischer, Krista; Esko, Tõnu; Westra, Harm-Jan; Fairfax, Benjamin P; Makino, Seiko; Knight, Julian C; Franke, Lude; Metspalu, Andres; Peterson, Pärt; Milani, Lili (2017). Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells. PLoS Genetics, 13 (3, 3), ARTN e1006643. DOI: 10.1371/journal.pgen.1006643.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994. DOI: 10.1038/ejhg.2017.90.
1.1.
2017
Duncan, Laramie; Yilmaz, Zeynep; Gaspar, Helena; Walters, Raymond; Goldstein, Jackie; Anttila, Verneri; Bulik-Sullivan, Brendan; Ripke, Stephan; Thornton, Laura; Daly, Mark; Sullivan, Patrick F.; Zeggini, Eleftheria; Breen, Gerome; Bulik, Cynthia M.; Adan, Roger; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole; Aschauer, Harald; Baker, Jessica ... Bulik, Cynthia M. (2017). Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. American Journal of Psychiatry, 174 (9), 850−858. DOI: 10.1176/appi.ajp.2017.16121402.
1.1.
2017
Ezzati, M; Bentham, J; Di Cesare, M; Bilano, V; Bixby, H; Zhou, B; Stevens, G.A; Riley, L.M Taddei, C; Hajifathalian, K ... NCD-RisC Group (NCD-RisC incl. Veidebaum, T) (2017). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. The Lancet, 390 (10113), 2627−2642. DOI: 10.1016/S0140-6736(17)32129-3.
6.8.
2017
Lokk, Kaie; Vooder, Tonu; Kolde, Raivo; Valk, Kristjan; Vosa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tonisson, Neeme (2017). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer (vol 7, e39813, 2012). PLoS ONE, 1, ARTN e0170833. DOI: 10.1371/journal.pone.0170833.
1.1.
2016
Joshi, Peter K; Fischer, Krista; Schraut, Katharina E; Campbell, Harry; Esko, Tõnu; Wilson, James F (2016). Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan. Nature Communications, 7 (11174), 11174−11174. DOI: 10.1038/ncomms11174.
1.1.
2016
Elosua, Roberto; Lluís-Ganella, Carla; Subirana, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin; Sayols-Baixeras, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí, Mariano; Siscovick, David; Melander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat, Jaume (2016). Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater than the Parts? A Genetic Approach. Circulation Cardiovascular Genetics, 9 (3), 279−286.
1.1.
2016
Läll, Kristi; Mägi, Reedik; Morris, Andrew; Metspalu, Andres; Fischer, Krista (2016). Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores. Genetics in Medicine, 1−10. DOI: 10.1038/gim.2016.103.
1.1.
2016
Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G; Social Science Genetic Association Consortium, Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences, 113 (47), 13366−13371. DOI: 10.1073/pnas.1605334113.
1.1.
2016
Veerus, P; Fischer, K; Hemminki, E; Hovi, SL; Hakama, M. (2016). Effect of characteristics of women on attendance in blind and non-blind randomised trials: analysis of recruitment data from the EPHT Trial. BMJ Open, 6 (10), e011099. DOI: 10.1136/bmjopen-2016-011099.
1.1.
2016
NCD Risk Factor Collaboration. (2016). A century of trends in adult human height. eLife, 5, Article Number: e13410. DOI: 10.7554/eLife.13410.
1.1.
2015
Fall, T; Hägg, S; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Sarin, AP; Benyamin, B; Ladenvall, C; Åkerlund, M; Kals, M; Esko, T; Nelson, CP; Kaakinen, M; Huikari, V; Mangino, M; Meirhaeghe, A; Kristiansson, K; Nuotio, ML; Kobl, M ... ENGAGE, Consortium. (2015). Age- and sex-specific causal effects of adiposity on cardiovascular risk factors. Diabetes, 64 (5), 1841−1852. DOI: 10.2337/db14-0988.
1.1.
2015
Locke, AE.; Kahali, B.; Berndt, SI.; Justice, AE.; Pers, TH.; Day, FR.; Powell, C.; Vedantam, S.; Buchkovich, ML.; Yang, J.; Croteau-Chonka, DC.; Esko, T.; Fall, T.; Ferreira, T.; Gustafsson, S.; Kutalik, Z.; Luan, J.; Mägi, R.; Randall, JC.; Winkler, TW. ... Speliotes, EK. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197−206. DOI: 10.1038/nature14177.
1.1.
2015
The, Coffee, and, Caffeine, Genetics, Consortium; Cornelis, MC; Byrne, EM; Esko, T; Nalls, MA; Ganna, A; Paynter, N; Monda, KL; Amin, N; Fischer, K; Renstrom, F; Ngwa, JS; Huikari, V; Cavadino, A; Nolte, IM; Teumer, A; Yu, K; Marques-Vidal, P; Rawal, R; Manichaikul, A ... Chasman, DI. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647−656. DOI: 10.1038/mp.2014.107.
1.1.
2015
Saar, Aet; Marandi, Toomas; Ainla, Tiia; Fischer, Krista; Blöndal, Mai; Eha, Jaan (2015). Improved treatment and prognosis after acute myocardial infarction in Estonia: cross-sectional study from a high risk country. BMC Cardiovascular Disorders, 15 (1), 136. DOI: 10.1186/s12872-015-0129-7.
1.1.
2015
Haller, Toomas; Kals, Mart; Esko, Tonu; Maegi, Reedik; Fischer, Krista (2015). RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations. Briefings in Bioinformatics, 16 (1), 39−44. DOI: 10.1093/bib/bbt066.
1.1.
2015
Hägg, S; Fall, T; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Kals, M; de Vries, PS; Dehghan, A; Willems, SM; Sarin, AP; Kristiansson, K; Nuotio, ML; Havulinna, AS; de Bruijn, RF; Ikram, MA; Kuningas, M; Stricker, BH; Franco, OH; Benyamin, B ... European, Network, for, Genetic, and, Genomic, Epidemiology, (ENGAGE) consortium. (2015). Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. International Journal of Epidemiology, 44 (2), 578−586. DOI: 10.1093/ije/dyv094.
1.1.
2015
Leitsalu, Liis; Haller, Toomas; Esko, Tõnu; Tammesoo, Mari-Liis; Alavere, Helene; Snieder, Harold; Perola, Markus; Ng, Pauline C; Mägi, Reedik; Milani, Lili; Fischer, Krista; Metspalu, Andres (2015). Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu. International Journal of Epidemiology, 44 (4), 1137−1147. DOI: 10.1093/ije/dyt268.
1.1.
2015
Heesen, C.; Kasper, J.; Fischer, K.; Koepke, S.; Rahn, A.; Backhus, I.; Poettgen, J.; Vahter, L.; Drulovic, J.; Van Nunen, A.; Beckmann, Y.; Liethmann, K.; Giordano, A.; Fulcher, G.; Solari, A.; AutoMS-group (2015). Risk Knowledge in Relapsing Multiple Sclerosis (RIKNO 1.0) - Development of an Outcome Instrument for Educational Interventions. PLoS ONE, 10 (10), ARTN e0138364. DOI: 10.1371/journal.pone.0138364.
1.3.
2015
Saar, Aet; Marandi, Toomas; Alver, Maris; Ainla, Tiia; Fischer, Krista; Eha, Jaan (2015). Südame isheemiatõve riski ennustamine geneetiliste markerite abil. Eesti Arst, 94 (9), 522−529.
5.1.
2015
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2015). MARV: Anovel method and software tool for genome-wide multi-phenotype analysis of rare variants. Genetic Epidemiology, 39 (7), 560−560.
24.03.2022

Krista Fischer

https://www.etis.ee/CV/Krista_Fischer/eng
krista.fischer@ut.ee

Career

Institutions and positions
01.01.2021–...   
University of Tartu, Faculty of Science and Technology, Institute of Genomics, Associate Professor of Biostatistics (0,20)
01.09.2018–...   
University of Tartu, Faculty of Science and Technology, Institute of Mathematics and Statistics, Professor of Mathematical Statistics (0,80)
01.09.2018–31.12.2020   
University of Tartu, Institute of Genomics, Senior Research Fellow of Biostatistics (0,20)
01.01.2018–31.08.2018   
University of Tartu, Institute of Genomics, Senior Research Fellow of Biostatistics (1,00)
01.02.2016–31.12.2017   
University of Tartu, Estonian Genome Center , Senior Research Fellow of Biostatistics (1,00)
01.01.2016–31.01.2016   
University of Tartu, Estonian Genome Center , Senior Specialist of Biostatistics (1,00)
01.01.2013–31.12.2015   
University of Tartu, Estonian Genome Center , Senior Research Fellow (1,00)
01.06.2010–31.12.2012   
University of Tartu, Estonian Genome Center , Senior Research Fellow in Genomics (1,00)
01.01.2010–31.05.2010   
University of Tartu, Estonian Genome Center , Senior Research Fellow in Genomics (0,10)
01.01.2007–31.12.2010   
MRC Biostatistics Unit, Cambridge, UK
01.09.2001–31.08.2006   
University of Tartu, Faculty of Medicine, Department of Public Health, Associate Professor (1,00)
01.01.1999–31.12.2001   
post-doctoral researcher at the University of Ghent, Belgium
1994–2000   
University of Tartu, Faculty of Mathematics and Computer Science, Institute of Mathematical Statistics, Chair of Mathematical Statistics, Researcher (1,00)
 
 
Education
1994–1999   
doctoral studies at the Institute of Mathematical Statistics, Faculty of Mathematics, University of Tartu, Estonia
1992–1994   
Master of Science in Biostatistics, Limburg University, Belgium
1988–1992   
undergraduate studies in Applied Mathematics, Faculty of Mathematics, University of Tartu, specialization in mathematical statistics
 
 
R&D related managerial and administrative work
2020−...   
Member of the Senat of the University of Tartu
2015−...   
International Biometric Society: Member of the Executive Board
2002−...   
Organizer of the international course "Statistical Practice in Epidemiology using R" (Tartu University, IARC, Lyon).
2020−2020   
Member of the International Programme Committee of the 41th Annual Conference of the International Society for Clinical Biostatistics
2017−2018   
Chair of the local organizing committee and member of the programme committee of the conference "Nordstat 2018".
2016−2017   
Chair of the local organizing committee of the European Mathematical Genetics Meeting 2017
2013−2016   
President of the Nordic-Baltic Region of the International Biometric Society
2011−2011   
Chair of the Scientific Programme Committee of the 3rd Nordic-Baltic Biometric Conference (Turku, Finland, June 6-9, 2011)
2011−2014   
Chair of the Education Committee of the International Biometric Society
2009−2009   
Chair of the Local Organizing Committee and member of the Scientific Programme Committee of the 2nd Nordic-Baltic Biometric Conference (Tartu, Estonia, 2009)
2003−2005   
Member of the scientific programme committee in the 7th Tartu Conference on Multivariate Statistics (Tartu, 2003) and the 26th Annual Conference of International Society for Clinical Biostatistics (Szeged, 2005).
2002−2010   
National Secretary of the Baltic Group of the International Biometric Society

Qualifications

Academic degrees
Krista Fischer, Doctor's Degree, 1999, (sup) Els Goetghebeur; Tõnu Kollo, Structural Mean Models for Analyzing the Effect of Compliance in Clinical Trials, University of Tartu, Faculty of Mathematics and Computer Science.
 
 
Fields of research
ETIS CLASSIFICATION: 4. Natural Sciences and Engineering; 4.5. Statistics; SPECIFICATION: biostatistics, causal inference in randomized trials
ETIS CLASSIFICATION: 3. Health; 3.11. Biochemistry, Genetics, Microbiology, Biotechnology, Molecular Biology, Cell Biology, Biophysics and Bioinformatics relating to Health Studies; SPECIFICATION: biostatistics, statistical methods in epidemiology and clinical research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS CLASSIFICATION: B110 Bioinformatics, medical informatics, biomathematics, biometrics ; SPECIFICATION: Statistical genetics, genetic epidemiology
 
 
Additional information
Doctor of Philosophy in Mathematical Statistics
Master of Science in Biostatistics
University of Tartu, 1999

Limburg University, Belgium, 1994

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2022
Macdonald-Dunlop, Erin; Taba, Nele; Klarić, Lucija; Frkatović, Azra; Walker, Rosie; Hayward, Caroline; Esko, Tõnu; Haley, Chris; Fischer, Krista; Wilson, James F.; Joshi, Peter K. (2022). A catalogue of omics biological ageing clocks reveals substantial commonality and associations with disease risk. Aging, 623−659. DOI: 10.18632/aging.203847.
1.1.
2022
Uusküla, A.; Kalda, R.; Solvak, M.; Jürisson, M.; Käärik, M.; Fischer, K.; Keis, A.; Raudvere, U.; Vilo, J.; Peterson, H.; Käärik, E.; Metspalu, M.; Jürgenson, T.; Milani, L.; Kolberg, L.; Tiit, E.-M.; Vassil, K. (2022). The 1st year of the COVID-19 epidemic in Estonia: a population-based nationwide sequential/consecutive cross-sectional study. Public Health, 205, 150−156. DOI: 10.1016/j.puhe.2022.02.004.
1.1.
2021
Barahona Ponce, Carol; Scherer, Dominique; Brinster, Regina; Boekstegers, Felix; Marcelain, Katherine; Gárate, Valentina; Müller, Bettina; de Toro, Gonzalo; Retamales, Javier; Barajas, Olga; Ahumada, Monica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo ... Lorenzo Bermejo, Justo (2021). Gallstones, Body Mass Index, C‐reactive Protein and Gallbladder Cancer – Mendelian Randomization Analysis of Chilean and European Genotype Data. Hepatology, 73 (5), 1783−1796. DOI: 10.1002/hep.31537.
1.1.
2021
Prins, Bram Peter; Leitsalu, Liis; Pärna, Katri; Fischer, Krista; Metspalu, Andres; Haller, Toomas; Snieder, Harold (2021). Advances in Genomic Discovery and Implications for Personalized Prevention and Medicine: Estonia as Example. Journal of Personalized Medicine, 11 (5). DOI: 10.3390/jpm11050358.
1.1.
2021
Ojavee, Sven E.; Kousathanas, Athanasios; Trejo Banos, Daniel; Orliac, Etienne J.; Patxot, Marion; Laell, Kristi; Maegi, Reedik; Fischer, Krista; Kutalik, Zoltan; Robinson, Matthew R. (2021). Genomic architecture and prediction of censored time-to-event phenotypes with a Bayesian genome-wide analysis. Nature Communications, 12 (1), ARTN 2337. DOI: 10.1038/s41467-021-22538-w.
1.1.
2021
Reintam Blaser, Annika; Padar, Martin; Mändul, Merli; Elke, Gunnar; Engel, Christoph; Fischer, Krista; Giabicani, Mikhael; Gold, Thomas; Hess, Benjamin; Hiesmayr, Michael; Jakob, Stephan M.; Loudet, Cecilia I.; Meesters, Dennis M.; Mongkolpun, Wasineenart; Paugam-Burtz, Catherine; Poeze, Martijn; Preiser, Jean-Charles; Renberg, Mattias; Rooijackers, Olav; Tamme, Kadri ... Starkopf, Joel (2021). Development of the Gastrointestinal Dysfunction Score (GIDS) for critically ill patients – A prospective multicenter observational study (iSOFA study). Clinical Nutrition, 40 (8), 4932−4940. DOI: 10.1016/j.clnu.2021.07.015.
1.1.
2021
Vojinovic, Dina; Kalaoja, Marita; Trompet, Stella; Fischer, Krista; Shipley, Martin J.; Li, Shuo; Havulinna, Aki S.; Perola, Markus; Salomaa, Veikko; Yang, Qiong; Sattar, Naveed; Jousilahti, Pekka; Amin, Najaf; Satizabal, Claudia L.; Taba, Nele; Sabayan, Behnam; Vasan, Ramachandran S.; Ikram, M. Arfan; Stott, David J.; Ala-Korpela, Mika ... van Duijn, Cornelia M. (2021). Association of Circulating Metabolites in Plasma or Serum and Risk of Stroke. Neurology, 96 (8), e1110−e1123. DOI: 10.1212/WNL.0000000000011236.
1.1.
2021
Munn-Chernoff, Melissa A.; Johnson, Emma C.; Chou, Yi-Ling; Coleman, Jonathan R. I.; Thornton, Laura M.; Walters, Raymond K.; Yilmaz, Zeynep; Baker, Jessica H.; Hubel, Christopher; Gordon, Scott; Medland, Sarah E.; Watson, Hunna J.; Gaspar, Helena A.; Bryois, Julien; Hinney, Anke; Leppa, Virpi M.; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodriguez, Paola ... Agrawal, Arpana (2021). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, 26 (1), ARTN e12880. DOI: 10.1111/adb.12880.
1.1.
2021
Iurilli, Maria L. C.; Zhou, Bin; Bennett, James E.; Carrillo-Larco, Rodrigo M.; Sophiea, Marisa K.; Rodriguez-Martinez, Andrea; Bixby, Honor; Solomon, Bethlehem D.; Taddei, Cristina; Danaei, Goodarz; Di Cesare, Mariachiara; Stevens, Gretchen A.; Riley, Leanne M.; Savin, Stefan; Cowan, Melanie J.; Bovet, Pascal; Damasceno, Albertino; Chirita-Emandi, Adela; Hayes, Alison J.; Ikeda, Nayu ... Filippi, Sarah (2021). Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC). eLife, 10 (e60060), ARTN e60060. DOI: 10.7554/eLife.60060.
1.1.
2021
Taba, Nele; Valge, Hanna-Kristel; Metspalu, Andres; Esko, Tonu; Wilson, James F.; Fischer, Krista; Pirastu, Nicola (2021). Mendelian Randomization Identifies the Potential Causal Impact of Dietary Patterns on Circulating Blood Metabolites. Frontiers in Genetics, 12, ARTN 738265. DOI: 10.3389/fgene.2021.738265.
1.1.
2021
Aasmets, Oliver; Lull, Kreete; Lang, Jennifer M.; Pan, Calvin; Kuusisto, Johanna; Fischer, Krista; Laakso, Markku; Lusis, Aldons J.; Org, Elin (2021). Machine Learning Reveals Time-Varying Microbial Predictors with Complex Effects on Glucose Regulation. mSystems, 6 (1), ARTN e01191-20. DOI: 10.1128/mSystems.01191-20.
1.1.
2020
Saar, Aet; Läll, Kristi; Alver, Maris; Marandi, Toomas; Ainla, Tiia; Eha, Jaan; Metspalu, Andres; Fischer, Krista (2020). Estimating the performance of three cardiovascular disease risk scores: the Estonian Biobank cohort study. Journal of Epidemiology & Community Health, 73 (3). DOI: 10.1136/jech-2017-209965.
1.1.
2020
Munn-Chernoff, Melissa A; Johnson, Emma C; Chou, Yi-Ling; Coleman, Jonathan R I; Thornton, Laura M; Walters, Raymond K; Yilmaz, Zeynep; Baker, Jessica H; Hübel, Christopher; Gordon, Scott; Medland, Sarah E; Watson, Hunna J; Gaspar, Héléna A; Bryois, Julien; Hinney, Anke; Leppä, Virpi M; Mattheisen, Manuel; Ripke, Stephan; Yao, Shuyang; Giusti-Rodríguez, Paola ... Agrawal, Arpana (2020). Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies. Addiction Biology, e12880−e12880. DOI: 10.1111/adb.12880.
1.1.
2020
Klarić, Lucija; Tsepilov, Yakov A; Stanton, Chloe M; Mangino, Massimo; Sikka, Timo Tõnis; Esko, Tõnu; Pakhomov, Eugene; Salo, Perttu; Deelen, Joris; McGurnaghan, Stuart J; Keser, Toma; Vučković, Frano; Ugrina, Ivo; Krištić, Jasminka; Gudelj, Ivan; Štambuk, Jerko; Plomp, Rosina; Pučić-Baković, Maja; Pavić, Tamara; Vilaj, Marija ... Hayward, Caroline (2020). Glycosylation of immunoglobulin G is regulated by a large network of genes pleiotropic with inflammatory diseases. Science Advances, 6 (8), eaax0301−eaax0301. DOI: 10.1126/sciadv.aax0301.
1.1.
2020
Bryois, Julien; Skene, Nathan G.; Hansen, Thomas Folkmann; Kogelman, Lisette J. A.; Watson, Hunna J.; Liu, Zijing; Brueggeman, Leo; Breen, Gerome; Bulik, Cynthia M.; Arenas, Ernest; Hjerling-Leffler, Jens; Sullivan, Patrick F. (2020). Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson's disease. Nature Genetics, 52 (5), 482−+. DOI: 10.1038/s41588-020-0610-9.
1.1.
2020
Marnetto, Davide; Pärna, Katri; Läll, Kristi; Molinaro, Ludovica; Montinaro, Francesco; Haller, Toomas; Metspalu, Mait; Mägi, Reedik; Fischer, Krista; Pagani, Luca (2020). Ancestry deconvolution and partial polygenic score can improve susceptibility predictions in recently admixed individuals. Nature Communications, 11 (1), 1628−1628. DOI: 10.1038/s41467-020-15464-w.
1.1.
2020
Hsu, Yu-Han H.; Astley, Christina M.; Cole, Joanne B.; Vedantam, Sailaja; Mercader, Josep M.; Metspalu, Andres; Fischer, Krista; Fortney, Kristen; Morgen, Eric K.; Gonzalez, Clicerio; Gonzalez, Maria E.; Esko, Tonu; Hirschhorn, Joel N. (2020). Integrating untargeted metabolomics, genetically informed causal inference, and pathway enrichment to define the obesity metabolome. International Journal of Obesity, 44 (7), 1596−1606. DOI: 10.1038/s41366-020-0603-x.
1.1.
2020
Parna, Katri; Snieder, Harold; Lall, Kristi; Fischer, Krista; Nolte, Ilja (2020). Validating the doubly weighted genetic risk score for the prediction of type 2 diabetes in the Lifelines and Estonian Biobank cohorts. Genetic Epidemiology, 44 (6), 589−600. DOI: 10.1002/gepi.22327.
1.1.
2020
Tillmann, Taavi; Läll, Kristi; Dukes, Oliver; Veronesi, Giovanni; Pikhart, Hynek; Peasey, Anne; Kubinova, Ruzena; Kozela, Magdalena; Pajak, Andrzej; Nikitin, Yuri; Malyutina, Sofia; Metspalu, Andres; Esko, Tõnu; Fischer, Krista; Kivimäki, Mika; Bobak, Martin (2020). Development and validation of two SCORE-based cardiovascular risk prediction models for Eastern Europe: a multicohort study. European Heart Journal, 41 (35), 3325−3333. DOI: 10.1093/eurheartj/ehaa571.
1.1.
2020
Rodriguez-Martinez, Andrea; Zhou, Bin; Sophiea, Marisa K; Bentham, James; Paciorek, Christopher J; Iurilli, Maria LC; Carrillo-Larco, Rodrigo M; Bennett, James E; Di Cesare, Mariachiara; Taddei, Cristina; Bixby, Honor; Stevens, Gretchen A; Riley, Leanne M; Cowan, Melanie J; Savin, Stefan; Danaei, Goodarz; Chirita-Emandi, Adela; Kengne, Andre P; Khang, Young-Ho; Laxmaiah, Avula ... Ezzati, Majid (2020). Height and body-mass index trajectories of school-aged children and adolescents from 1985 to 2019 in 200 countries and territories: a pooled analysis of 2181 population-based studies with 65 million participants. The Lancet, 396 (10261), 1511−1524. DOI: 10.1016/S0140-6736(20)31859-6.
5.1.
2020
Taba, N.; Fischer, K.; Esko, T.; Metspalu, A.; Pirastu, N. (2020). Causal Relationships between Dietary Items and Blood Metabolites Using Mendelian Randomization. Human Heredity, 84 (4-5), 225−226.
6.8.
2020
Ponce, Carol Barahona; Scherer, Dominique; Boekstegers, Felix; Garate-Calderon, Valentina; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Weiderpass, Elisabete; Bonet, Catalina; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Schoettker, Ben; Holleczek, Bernd; Hveem, Kristian; Eklund, Niina; Voelker, Uwe; Waldenberger, Melanie; Bermejo, Justo Lorenzo (2020). Arsenic and gallbladder cancer risk: Mendelian randomization analysis of European prospective data. International Journal of Cancer, 146 (9), 2648−2650. DOI: 10.1002/ijc.32837.
1.1.
2019
Hõrak, Peeter; Valge, Markus, Fischer, Krista; Mägi, Reedik; Kaart, Tanel (2019). Parents of early maturing girls die younger. Evolutionary Applications, 12 (5), 1050−1061. DOI: 10.1111/eva.12780.
1.1.
2019
Timmers, Paul Rhj; Mounier, Ninon; Lall, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew D; Clark, David W; ,; Agbessi, M; Ahsan, H; Alves, I; Andiappan, A; Awadalla, P; Battle, A; Bonder, M J; Boomsma, D; Christiansen, M; Claringbould, A; Deelen, P ... Joshi, Peter K (2019). Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances. eLife, 8, e39856. DOI: 10.7554/eLife.39856.
1.1.
2019
Läll, Kristi; Lepamets, Maarja; Palover, Marili; Esko, Tõnu; Metspalu, Andres; Tõnisson, Neeme; Padrik, Peeter; Mägi, Reedik; Fischer, Krista (2019). Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification. BMC Cancer, 19 (1), ARTN 557. DOI: 10.1186/s12885-019-5783-1.
1.1.
2019
Sarin, Heikki V; Taba, Nele; Fischer, Krista; Esko, Tonu; Kanerva, Noora; Moilanen, Leena; Saltevo, Juha; Joensuu, Anni; Borodulin, Katja; Männistö, Satu; Kristiansson, Kati; Perola, Markus (2019). Food neophobia associates with poorer dietary quality, metabolic risk factors, and increased disease outcome risk in population-based cohorts in a metabolomics study. American Journal of Clinical Nutrition, 110 (1), 233−245. DOI: 10.1093/ajcn/nqz100.
1.1.
2019
Bixby, Honor; Bentham, James; Zhou, Bin; Di Cesare, Mariachiara; Paciorek, Christopher J.; Bennett, James E.; Taddei, Cristina; Stevens, Gretchen A.; Rodriguez-Martinez, Andrea; Carrillo-Larco, Rodrigo M.; Khang, Young-Ho; Soric, Maroje; Gregg, Edward W.; Miranda, J. Jaime; Bhutta, Zulfiqar A.; Savin, Stefan; Sophiea, Marisa K.; Iurilli, Maria L. C.; Solomon, Bethlehem D.; Cowan, Melanie J. ... Ezzati, Majid (2019). Rising rural body-mass index is the main driver of the global obesity epidemic in adults. Nature, 569 (7755), 260−281. DOI: 10.1038/s41586-019-1171-x.
1.1.
2019
van der Lee, Sven J.; Teunissen, Charlotte E.; Pool, Rene; Shipley, Martin J.; Teumer, Alexander; Chouraki, Vincent; van Lent, Debora Melo; Tynkkynen, Juho; Fischer, Krista; Hernesniemi, Jussi; Haller, Toomas; Singh-Manoux, Archana; Verhoeven, Aswin; Willemsen, Gonneke; de Leeuw, Francisca A.; Wagner, Holger; van Dongen, Jenny; Hertel, Johannes; Budde, Kathrin; van Dijk, Ko Willems ... van Duijn, Cornelia M. (2019). Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies (vol 14, pg 707, 2018). In: (319−319). NEW YORK: ELSEVIER SCIENCE INC. (15). DOI: 10.1016/j.jalz.2019.01.002.
1.1.
2019
Hsu, Yu-Han H; Churchhouse, Claire; Pers, Tune H; Mercader, Josep M; Metspalu, Andres; Fischer, Krista; Fortney, Kristen; Morgen, Eric K; Gonzalez, Clicerio; Gonzalez, Maria E; Esko, Tonu; Hirschhorn, Joel N (2019). PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data. PLoS Computational Biology, 15 (1), e1006734−e1006734. DOI: 10.1371/journal.pcbi.1006734.
1.1.
2019
Deelen, Joris; Kettunen, Johannes; Fischer, Krista; van der Spek, Ashley; Trompet, Stella; Kastenmueller, Gabi; Boyd, Andy; Zierer, Jonas; van den Akker, Erik B.; Ala-Korpela, Mika; Amin, Najaf; Demirkan, Ayse; Ghanbari, Mohsen; van Heemst, Diana; Ikram, M. Arfan; van Klinken, Jan Bert; Mooijaart, Simon P.; Peters, Annette; Salomaa, Veikko; Sattar, Naveed ... Slagboom, P. Eline (2019). A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals. Nature Communications, 10, ARTN 3346. DOI: 10.1038/s41467-019-11311-9.
1.1.
2019
Ho, Andrew; Sinick, Jonah; Esko, Tonu; Fischer, Krista; Menni, Cristina; Zierer, Jonas; Matey-Hernandez, Maria; Fortney, Kristen; Morgen, Eric K. (2019). Circulating glucuronic acid predicts healthspan and longevity in humans and mice. Aging, 11 (18), 7694−7706. DOI: 10.18632/aging.102281.
1.1.
2019
Rosticci, Martina; Pervjakova, Natalia; Kaakinen, Marika; Cicero, Arrigo F.; Feufer, Arne P.; Marullo, Letizia; Magi, Reedik; Fischer, Krista; Jiang, Longda; D'Addato, Sergio; Rizzoli, Elisabetta; Massimo, Gianmichele; Giovannini, Marina; Angelini, Sabrina; Hrelia, Patrizia; Scapoli, Chiara; Borghi, Claudio; Prokopenko, Inga (2019). A meta-analysis of Italian and Estonian individuals shows an effect of common variants in HMGCR on blood apoB levels. Biomarkers in Medicine, 13 (11), 931−940. DOI: 10.2217/bmm-2017-0431.
1.1.
2019
van der Spek, Ashley; Broer, Linda; Draisma, Harmen H. M.; Pool, Rene; Albrecht, Eva; Beekman, Marian; Mangino, Massimo; Raag, Mait; Nyholt, Dale R.; Dharuri, Harish K.; Codd, Veryan; Amin, Najaf; de Geus, Eco J. C.; Deelen, Joris; Demirkan, Ayse; Yet, Idil; Fischer, Krista; Haller, Toomas; Henders, Anjali K.; Isaacs, Aaron ... Gieger, Christian (2019). Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium. Scientific Reports, 9 (1), 1162323. DOI: 10.1038/s41598-019-47282-6.
1.1.
2019
Clark, David W.; Okada, Yukinori; Moore, Kristjan H. S.; Mason, Dan; Pirastu, Nicola; Gandin, Ilaria; Mattsson, Hannele; Barnes, Catriona L. K.; Lin, Kuang; Zhao, Jing Hua; Deelen, Patrick; Rohde, Rebecca; Schurmann, Claudia; Guo, Xiuqing; Giulianini, Franco; Zhang, Weihua; Medina-Gomez, Carolina; Karlsson, Robert; Bao, Yanchun; Bartz, Traci M. ... Wilson, James F. (2019). Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, ARTN 4957. DOI: 10.1038/s41467-019-12283-6.
1.1.
2019
Yao, Shuyang; Kuja-Halkola, Ralf; Martin, Joanna; Lu, Yi; Lichtenstein, Paul; Norring, Claes; Birgegard, Andreas; Yilmaz, Zeynep; Hubel, Christopher; Watson, Hunna; Baker, Jessica; Almqvist, Catarina; Thornton, Laura M.; Magnusson, Patrik K.; Bulik, Cynthia M.; Larsson, Henrik; Adan, Roger; Ando, Tetsuya; Bergen, Andrew; Berrettini, Wade ... Bulik, Cynthia (2019). Associations Between Attention-Deficit/Hyperactivity Disorder and Various Eating Disorders: A Swedish Nationwide Population Study Using Multiple Genetically Informative Approaches. Biological Psychiatry, 86 (8), 577−586. DOI: 10.1016/j.biopsych.2019.04.036.
1.1.
2019
Watson, Hunna J.; Yilmaz, Zeynep; Thorntont, Laura M.; Hubel, Christopher; Coleman, Jonathan R., I; Gaspar, Helena A.; Bryois, Julien; Hinney, Anke; Leppa, Virpi M.; Mattheisen, Manuel; Medland, Sarah E.; Ripke, Stephan; Yao, Shuyang; Giusti-Rodriguez, Paola; Hanscombe, Ken B.; Purves, Kirstin L.; Adan, Roger A. H.; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole A. ... Bulik, Cynthia M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51 (8), 1207−+. DOI: 10.1038/s41588-019-0439-2.
1.3.
2019
Laas, Karin; Teär, Carmen Marianne; Pehme, Lea; Viiklepp, Piret; Fischer, Krista; Tammaru, Marika (2019). Reumatoidartriidi patsientide haigestumus tuberkuloosi enne ja pärast bioloogilise ravi kasutuselevõttu Eestis: kahe perioodi võrdlus. Eesti Arst.
5.1.
2019
Tõnisson, Neeme; Roht; Laura; Palover, Marili; Leitsalu, Liis; Läll, Kristi; Fischer; Kruuv-Käo, Krista; Eelma, Evelyn; Lehtsaar, Jaak; Jürgens, Hannes; Kütner, Riina; Valvere, Vahur; Nikopensius, Tiit; Reigo, Anu: Tammesoo, Mari-Liis; Esko, Tõnu; Metspalu, Andres; Padrik, Peeter (2019). Genotype first female breast cancer risk-based screening and management, initial lessons from a national pilot project. European Journal of Human Genetics, 10: European Human Genetics Conference, 15–18 juuni, 2019. Nature Research. (SUPPLEMENT).
1.1.
2018
Saar, Aet; Marandi, Toomas; Ainla, Tiia; Fischer, Krista; Blöndal, Mai; Eha, Jaan (2018). The risk-treatment paradox in non-ST-elevation myocardial infarction patients according to their estimated GRACE risk. International Journal of Cardiology, 272, 26−32. DOI: 10.1016/j.ijcard.2018.08.015.
1.1.
2018
Tynkkynen J., Chouraki V., van der Lee S.J, Hernesniemi J., Yang, Q., Li, S., Beiser, A., Larson, M.G., Sääksjärvi, K., Shipley, M.,J., Singh-Manoux, A., Gerszten, R.E., Wang T.J., Havulinna A.S., Würtz P., Fischer K., Demirkan A., Ikram M.A., Amin N., Lehtimäki T, Kähönen M., Perola M., Metspalu A., Kangas A., Soininen P., Ala-Korpela M., Vasan R.S., Kivimäki M., van Duijn C.M, Seshadri S., Salomaa V. (2018). Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimer's & Dementia, 723−733. DOI: 10.1016/j.jalz.2018.01.003.
1.1.
2018
Mahajan, Anubha; Taliun, Daniel; Thurner, Matthias; Robertson, Neil R.; Torres, Jason M.; Rayner, N. William; Payne, Anthony J.; Steinthorsdottir, Valgerdur; Scott, Robert A.; Grarup, Niels; Cook, James P.; Schmidt, Ellen M.; Wuttke, Matthias; Sarnowski, Chloe; Magill, Reedik; Nano, Jana; Gieger, Christian; Trompet, Stella; Lecoeur, Cecile; Preuss, Michael H. ... McCarthy, Mark, I (2018). Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps. Nature Genetics, 50 (11), 1505−1516. DOI: 10.1038/s41588-018-0241-6.
1.1.
2018
van der Lee, Sven J.; Teunissen, Charlotte E.; Pool, Rene; Shipley, Martin J.; Teumer, Alexander; Chouraki, Vincent; van Lent, Debora Melo; Tynkkynen, Juho; Fischer, Krista; Hernesniemi, Jussi; Haller, Toomas; Singh-Manoux, Archana; Verhoeven, Aswin; Willemsen, Gonneke; de Leeuw, Francisca A.; Wagner, Holger; van Dongen, Jenny; Hertel, Johannes; Budde, Kathrin; van Dijk, Ko Willems ... van Duijn, Cornelia M. (2018). Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies. Alzheimer's & Dementia, 14 (6), 707−722. DOI: 10.1016/j.jalz.2017.11.012.
1.1.
2018
Parmar, Priyanka; Lowry, Estelle; Cugliari, Giovanni; Suderman, Matthew; Wilson, Rory; Karhunen, Ville; Andrew, Toby; Wiklund, Petri; Wielscher, Matthias; Guarrera, Simonetta; Teumer, Alexander; Lehne, Benjamin; Milani, Lili; de Klein, Niek; Mishra, Pashupati P.; Melton, Phillip E.; Mandaviya, Pooja R.; Kasela, Silva; Nano, Jana; Zhang, Weihua ... Sebert, Sylvain (2018). Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults. EBioMedicine, 38, 206−216. DOI: 10.1016/j.ebiom.2018.10.066.
1.1.
2018
Ligthart, Symen; Vaez, Ahmad; Võsa, Urmo; Stathopoulou, Maria G; de Vries, Paul S; Prins, Bram P; Van der Most, Peter J; Tanaka, Toshiko; Naderi, Elnaz; Rose, Lynda M; Wu, Ying; Karlsson, Robert; Barbalic, Maja; Lin, Honghuang; Pool, René; Zhu, Gu; Macé, Aurélien; Sidore, Carlo; Trompet, Stella; Mangino, Massimo ... Alizadeh, Behrooz Z (2018). Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders. The American Journal of Human Genetics, 103 (5), 691−706. DOI: 10.1016/j.ajhg.2018.09.009.
1.1.
2018
Mahajan, Anubha; Wessel, Jennifer; Willems, Sara M; Zhao, Wei; Robertson, Neil R; Chu, Audrey Y; Gan, Wei; Kitajima, Hidetoshi; Taliun, Daniel; Rayner, N William; Guo, Xiuqing; Lu, Yingchang; Li, Man; Jensen, Richard A; Hu, Yao; Huo, Shaofeng; Lohman, Kurt K; Zhang, Weihua; Cook, James P; Prins, Bram Peter ... McCarthy, Mark I (2018). Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. Nature Genetics, 50 (4), 559−571. DOI: 10.1038/s41588-018-0084-1.
1.1.
2018
Zhou, Bin; Bentham, James; Di Cesare, Mariachiara; Bixby, Honor; Danaei, Goodarz; Hajifathalian, Kaveh; Taddei, Cristina; Carrillo-Larco, Rodrigo M.; Djalalinia, Shirin; Khatibzadeh, Shahab; Lugero, Charles; Peykari, Niloofar; Zhang, Wan Zhu; Bennett, James; Bilano, Ver; Stevens, Gretchen A.; Cowan, Melanie J.; Riley, Leanne M.; Chen, Zhengming; Hambleton, Ian R. ... Cisneros, Julio Zuniga (2018). Contributions of mean and shape of blood pressure distribution to worldwide trends and variations in raised blood pressure: a pooled analysis of 1018 population-based measurement studies with 88.6 million participants. International Journal of Epidemiology, 47 (3), 872−893. DOI: 10.1093/ije/dyy016.
5.2.
2018
Saar, A; Marandi, T; Ainla, T; Fischer, K; Blöndal, M, Eha, J (2018). The treatment and mortality of patients with non-ST-segment elevation myocardial infarction according to estimated risk - real world data from Estonian Myocardial Infarction Registry. European Heart Journal: Acute Cardiovascular Care: Acute Cardiovascular Care 2018, Milano. Sage Publications Ltd.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). MARV: a tool for genome-wide multi-phenotype analysis of rare variants. BMC Bioinformatics, ARTN 110. DOI: 10.1186/s12859-017-1530-2.
1.1.
2017
Mägi, Reedik; Suleimanov, Yury V.; Clarke, Geraldine M.; Kaakinen, Marika; Fischer, Krista; Prokopenko, Inga; Morris, Andrew P. (2017). SCOPA and META-SCOPA: software for the analysis and aggregation of genome-wide association studies of multiple correlated phenotypes. BMC Bioinformatics, ARTN 25. DOI: 10.1186/s12859-016-1437-3.
1.1.
2017
Guo, Michael H.; Nandakumar, Satish K.; Ulirsch, Jacob C.; Zekavat, Seyedeh M.; Buenrostro, Jason D.; Natarajan, Pradeep; Salem, Rany M.; Chiarle, Roberto; Mitt, Mario; Kals, Mart; Parn, Kalle; Fischer, Krista; Milani, Lili; Magi, Reedik; Palta, Priit; Gabriel, Stacey B.; Metspalu, Andres; Lander, Eric S.; Kathiresan, Sekar; Hirschhorn, Joel N. ... Sankaran, Vijay G. (2017). Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences, 114 (3), E327−E336. DOI: 10.1073/pnas.1619052114.
1.1.
2017
Haller, Toomas; Leitsalu, Liis; Fischer, Krista; Nuotio, Marja-Liisa; Esko, Tonu; Boomsma, Dorothea Irene; Kyvik, Kirsten Ohm; Spector, Tim D.; Perola, Markus; Metspalu, Andres (2017). MixFit: Methodology for Computing Ancestry-Related Genetic Scores at the Individual Level and Its Application to the Estonian and Finnish Population Studies. PLoS ONE, 12 (1), ARTN e0170325. DOI: 10.1371/journal.pone.0170325.
1.1.
2017
Hinney A, Kesselmeier M, Jall S, Volckmar AL, Föcker M, Antel J; GCAN; WTCCC3, Heid IM, Winkler TW; GIANT, Grant SF; EGG, Guo Y, Bergen AW, Kaye W, Berrettini W, Hakonarson H; Price Foundation Collaborative Group; Children’s Hospital of Philadelphia/Price Foundation, Herpertz-Dahlmann B, de Zwaan M, Herzog W, Ehrlich S, Zipfel S, Egberts KM, Adan R, Brandys M, van Elburg A, Boraska Perica V, Franklin CS, Tschöp MH, Zeggini E, Bulik CM, Collier D, Scherag A, Müller TD, Hebebrand J. (2017). Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index. Molecular Psychiatry, 22 (2), 192−201. DOI: 10.1038/mp.2016.71.
1.1.
2017
Wahl, Simone; Drong, Alexander; Lehne, Benjamin; Loh, Marie; Scott, William R; Kunze, Sonja; Tsai, Pei-Chien; Ried, Janina S; Zhang, Weihua; Yang, Youwen; Tan, Sili; Fiorito, Giovanni; Franke, Lude; Guarrera, Simonetta; Kasela, Silva; Kriebel, Jennifer; Richmond, Rebecca C; Adamo, Marco; Afzal, Uzma; Ala-Korpela, Mika ... Chambers, John C (2017). Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity. Nature, 541 (7635), 81−86. DOI: 10.1038/nature20784.
1.1.
2017
Reisberg, Sulev; Iljasenko, Tatjana; Läll, Kristi; Fischer, Krista; Vilo, Jaak (2017). Comparing distributions of polygenic risk scores of type 2 diabetes and coronary heart disease within different populations. PLoS ONE, 12 (7), e0179238−e0179238. DOI: 10.1371/journal.pone.0179238.
1.1.
2017
Shungin, Dmitry; Deng, Wei Q.; Varga, Tibor V.; Luan, Jian'an; Mihailov, Evelin; Metspalu, Andres; Morris, Andrew P.; Forouhi, Nita G.; Lindgren, Cecilia; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Hallmans, Goran; Chu, Audrey Y.; Justice, Anne E.; Graff, Mariaelisa; Winkler, Thomas W.; Rose, Lynda M.; Langenberg, Claudia; Cupples, L. Adrienne; Ridker, Paul M. ... Franks, Paul W. (2017). Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genetics, 13 (6), e1006812. DOI: 10.1371/journal.pgen.1006812.
1.1.
2017
Joshi, P. K., Pirastu, N., Kentistou, K. A., Fischer, K., Hofer, E., Schraut, K. E., Clark D.W., Nutile T., Barnes C.L.K., Timmers P.R.H.J., Shen X., Gandin I., McDaid A.F., Hansen T.F., Gordon S.D., Giulianini F., Boutin T.S., Abdellaoui A., Zhao W., Medina-Gomez C., Bartz T.M., Trompet S., Lange L.A., Raffield L., van der Spek A.,/.../,Bertram L., Pendleton N., Kardia S.L.R., Ciullo M., Becker D.M., Wong A., Psaty B.M., van Duijn C.M., Wilson J.G., Jukema J.W., Kiemeney L., Uitterlinden A.G, Franceschini N., North K.E., Weir D.R., Metspalu A., Boomsma D.I., Hayward C., Chasman D., Martin N.G., Sattar N., Campbell H., Esko T., Kutalik Z., Wilson J.F. (2017). Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, 910. DOI: 10.1038/s41467-017-00934-5.
1.1.
2017
Kõks G, Fischer K, Kõks S. (2017). Smoking-related general and cause-specific mortality in Estonia. BMC Public Health, 18 (1), 34. DOI: 10.1186/s12889-017-4590-3.
1.1.
2017
Tillmann T., Vaucher J., Okbay A., Pikhart H., Peasey A., Kubinova R., Pajak A., Tamosiunas A, Malyutina S., Hartwig F.P., Fischer K., Veronesi G., Palmer T., Bowden J., Davey Smith G., Bobak M., Holmes M.V. (2017). Education and coronary heart disease: mendelian randomisation study. British Medical Journal, 358, j3542. DOI: 10.1136/bmj.j3542.
1.1.
2017
Justice, Anne E.; Winkler, Thomas W.; Feitosa, Mary F.; Graff, Misa; Fisher, Virginia A.; Young, Kristin; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S.; Ahluwalia, Tarunveer S.; Chu, Audrey Y.; Heard-Costa, Nancy L.; Lim, Elise; Perez, Jeremiah; Eicher, John D.; Kutalik, Zoltan; Xue, Luting; Mahajan, Anubha ... Cupples, L. Adrienne (2017). Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nature Communications, 8 (14977), ARTN 14977. DOI: 10.1038/ncomms14977.
1.1.
2017
Kasela, Silva; Kisand, Kai; Tserel, Liina; Kaleviste, Epp; Remm, Anu; Fischer, Krista; Esko, Tõnu; Westra, Harm-Jan; Fairfax, Benjamin P; Makino, Seiko; Knight, Julian C; Franke, Lude; Metspalu, Andres; Peterson, Pärt; Milani, Lili (2017). Pathogenic implications for autoimmune mechanisms derived by comparative eQTL analysis of CD4(+) versus CD8(+) T cells. PLoS Genetics, 13 (3, 3), ARTN e1006643. DOI: 10.1371/journal.pgen.1006643.
1.1.
2017
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Heikkinen, Jani; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2017). A rare-variant test for high-dimensional data. European Journal of Human Genetics, 25 (8), 988−994. DOI: 10.1038/ejhg.2017.90.
1.1.
2017
Duncan, Laramie; Yilmaz, Zeynep; Gaspar, Helena; Walters, Raymond; Goldstein, Jackie; Anttila, Verneri; Bulik-Sullivan, Brendan; Ripke, Stephan; Thornton, Laura; Daly, Mark; Sullivan, Patrick F.; Zeggini, Eleftheria; Breen, Gerome; Bulik, Cynthia M.; Adan, Roger; Alfredsson, Lars; Ando, Tetsuya; Andreassen, Ole; Aschauer, Harald; Baker, Jessica ... Bulik, Cynthia M. (2017). Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa. American Journal of Psychiatry, 174 (9), 850−858. DOI: 10.1176/appi.ajp.2017.16121402.
1.1.
2017
Ezzati, M; Bentham, J; Di Cesare, M; Bilano, V; Bixby, H; Zhou, B; Stevens, G.A; Riley, L.M Taddei, C; Hajifathalian, K ... NCD-RisC Group (NCD-RisC incl. Veidebaum, T) (2017). Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults. The Lancet, 390 (10113), 2627−2642. DOI: 10.1016/S0140-6736(17)32129-3.
5.1.
2017
Taba, Nele; Fischer, Krista; Esko, Tonu; Metspalu, Andres; Pirastu, Nicola (2017). Investigating Causal Relationships Between Dietary Items and Blood Metabolites Using 2-Sample Mendelian Randomization. Human Heredity, 83 (5), 244−245.
5.1.
2017
Taba, Nele; Esko, Tonu; Metspalu, Andres; Fischer, Krista (2017). Empirically Derived Dietary Patterns - Characteristics, Phenotypic Background, and Associations with NMR Metabolites and Health Outcomes in the Estonian Biobank Cohort. Human Heredity, 83 (1), 24−24.
5.1.
2017
Timmers, Paul R. H. J.; Mounier, Ninon; Lall, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew; Clark, David W.; Shen, Xia; Esko, Tonu; Kutalik, Zoltan; Wilson, James F.; Joshi, Peter K. (2017). The Genomic Basis of Human Lifespan. Human Heredity, 83 (1), 12−12.
5.1.
2017
Fischer, Krista; Lall, Kristi; Esko, Tonu (2017). Integration of Polygenic Risk Estimates into Personalized Risk Prediction Algorithms - Experience from the Estonian Biobank. Human Heredity, 83 (1), 7−7.
5.1.
2017
Mounier, Ninon; Timmers, Paul R. H. J.; Lall, Kristi; Fischer, Krista; Ning, Zheng; Feng, Xiao; Bretherick, Andrew; Clark, David W.; Shen, Xia; Esko, Tonu; Wilson, James F.; Joshi, Peter K.; Kutalik, Zoltan (2017). Bayesian Genome-Wide Association Study to Discover Novel Lifespan-Associated Loci. Human Heredity, 83 (1), 18−18.
5.1.
2017
Kaakinen, Marika; Magi, Reedik; Lagou, Vasiliki; Claringbould, Annique; Gaulton, Kyle; Fischer, Krista; Morris, Andrew; Prokopenko, Inga (2017). Multi-Phenotype Genome-Wide Meta-Analysis of Lipid Levels and BMI in 64,736 Europeans Suggests Shared Genetic Architecture. Genetic Epidemiology, 41 (7), 652−653.
6.8.
2017
Lokk, Kaie; Vooder, Tõnu; Kolde, Raivo; Välk, Kristjan; Võsa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tõnisson, Neeme (2017). Correction: Methylation Markers of Early-Stage Non-Small Cell Lung Cancer. PLoS ONE, 12 (1), e0170833−e0170833. DOI: 10.1371/journal.pone.0170833.
6.8.
2017
Lokk, Kaie; Vooder, Tonu; Kolde, Raivo; Valk, Kristjan; Vosa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltsina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tonisson, Neeme (2017). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer (vol 7, e39813, 2012). PLoS ONE, 1, ARTN e0170833. DOI: 10.1371/journal.pone.0170833.
1.1.
2016
Joshi, Peter K; Fischer, Krista; Schraut, Katharina E; Campbell, Harry; Esko, Tõnu; Wilson, James F (2016). Variants near CHRNA3/5 and APOE have age- and sex-related effects on human lifespan. Nature Communications, 7 (11174), 11174−11174. DOI: 10.1038/ncomms11174.
1.1.
2016
Elosua, Roberto; Lluís-Ganella, Carla; Subirana, Isaac; Havulinna, Aki; Läll, Kristi; Lucas, Gavin; Sayols-Baixeras, Sergi; Pietilä, Arto; Alver, Maris; Cabrera de León, Antonio; Sentí, Mariano; Siscovick, David; Melander, Olle; Fischer, Krista; Salomaa, Veikko; Marrugat, Jaume (2016). Cardiovascular Risk Factors and Ischemic Heart Disease: Is the Confluence of Risk Factors Greater than the Parts? A Genetic Approach. Circulation Cardiovascular Genetics, 9 (3), 279−286.
1.1.
2016
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A, Surendran P, Saleheen D, Trompet S, Jukema JW, De Craen A, Deloukas P, Sattar N, Ford I, Packard C, Majumder Aa, Alam DS, Di Angelantonio E, Abecasis G, Chowdhury R, Erdmann J, Nordestgaard BG, Nielsen SF, Tybjærg-Hansen A, Schmidt RF, Kuulasmaa K, Liu DJ, Perola M, Blankenberg S, Salomaa V, Männistö S, Amouyel P, Arveiler D, Ferrieres J, Müller-Nurasyid M, Ferrario M, Kee F, Willer CJ, Samani N, Schunkert H, Butterworth AS, Howson JM, Peloso GM, Stitziel NO, Danesh J, Kathiresan S, Rader DJ; CHD Exome+ Consortium; CARDIoGRAM Exome Consortium; Global Lipids Genetics Consortium. (2016). Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science, 351 (6278), 1166−1171. DOI: 10.1126/science.aad3517.
1.1.
2016
Läll, Kristi; Mägi, Reedik; Morris, Andrew; Metspalu, Andres; Fischer, Krista (2016). Personalized risk prediction for type 2 diabetes: the potential of genetic risk scores. Genetics in Medicine, 1−10. DOI: 10.1038/gim.2016.103.
1.1.
2016
Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N, Jia T, Preis S, Segura Lepe M, Akira S, Barbieri C, Baumeister S, Cauchi S, Clarke TK, Enroth S, Fischer K, Hällfors J, Harris SE, Hieber S, Hofer E, Hottenga JJ, Johansson Å, Joshi PK, Kaartinen N, Laitinen J, Lemaitre R, Loukola A, Luan J, Lyytikäinen LP, Mangino M, Manichaikul A, Mbarek H, Milaneschi Y, Moayyeri A, Mukamal K, Nelson C, Nettleton J, Partinen E, Rawal R, Robino A, Rose L, Sala C, Satoh T, Schmidt R, Schraut K, Scott R, Smith AV, Starr JM, Teumer A, Trompet S, Uitterlinden AG, Venturini C, Vergnaud AC, Verweij N, Vitart V, Vuckovic D, Wedenoja J, Yengo L, Yu B, Zhang W, Zhao JH, Boomsma DI, Chambers J, Chasman DI, Daniela T, de Geus E, Deary I, Eriksson JG, Esko T, Eulenburg V, Franco OH, Froguel P, Gieger C, Grabe HJ, Gudnason V, Gyllensten U, Harris TB, Hartikainen AL, Heath AC, Hocking L, Hofman A, Huth C, Jarvelin MR, Jukema JW, Kaprio J, Kooner JS, Kutalik Z, Lahti J, Langenberg C, Lehtimäki T, Liu Y, Madden PA, Martin N, Morrison A, Penninx B, Pirastu N, Psaty B, Raitakari O, Ridker P, Rose R, Rotter JI, Samani NJ, Schmidt H, Spector TD, Stott D, Strachan D, Tzoulaki I, van der Harst P, van Duijn CM, Marques-Vidal P, Vollenweider P, Wareham NJ, Whitfield JB, Wilson J, Wolffenbuttel B, Bakalkin G, Evangelou E, Liu Y, Rice KM, Desrivières S, Kliewer SA, Mangelsdorf DJ, Müller CP, Levy D, Elliott P. (2016). KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. Proceedings of the National Academy of Sciences, 113 (50), 14372−14377. DOI: 10.1073/pnas.1611243113.
1.1.
2016
Marioni RE, Ritchie SJ, Joshi PK, Hagenaars SP, Okbay A, Fischer K, Adams MJ, Hill WD, Davies G; Social Science Genetic Association Consortium, Nagy R, Amador C, Läll K, Metspalu A, Liewald DC, Campbell A, Wilson JF, Hayward C, Esko T, Porteous DJ, Gale CR, Deary IJ. (2016). Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences, 113 (47), 13366−13371. DOI: 10.1073/pnas.1605334113.
1.1.
2016
Veerus, P; Fischer, K; Hemminki, E; Hovi, SL; Hakama, M. (2016). Effect of characteristics of women on attendance in blind and non-blind randomised trials: analysis of recruitment data from the EPHT Trial. BMJ Open, 6 (10), e011099. DOI: 10.1136/bmjopen-2016-011099.
1.1.
2016
NCD Risk Factor Collaboration. (2016). A century of trends in adult human height. eLife, 5, Article Number: e13410. DOI: 10.7554/eLife.13410.
1.1.
2015
Fall, T; Hägg, S; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Sarin, AP; Benyamin, B; Ladenvall, C; Åkerlund, M; Kals, M; Esko, T; Nelson, CP; Kaakinen, M; Huikari, V; Mangino, M; Meirhaeghe, A; Kristiansson, K; Nuotio, ML; Kobl, M ... ENGAGE, Consortium. (2015). Age- and sex-specific causal effects of adiposity on cardiovascular risk factors. Diabetes, 64 (5), 1841−1852. DOI: 10.2337/db14-0988.
1.1.
2015
Peyrot, WJ; Lee, SH; Milaneschi, Y; Abdellaoui, A; Byrne, EM; Esko, T; de, Geus, EJ; Hemani, G; Hottenga, JJ; Kloiber, S; Levinson, DF; Lucae, S; Martin, NG; Medland, SE; Metspalu, A; Milani, L; Noethen, MM; Potash, JB; Rietschel, M; Rietveld, CA ... SSGAC, Corporate, Collaborator. (2015). The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25 000 subjects. Molecular Psychiatry, 20 (6), 735−743. DOI: 10.1038/mp.2015.50.
1.1.
2015
Shungin, D; Winkler, TW; Croteau-Chonka, DC; Ferreira, T; Locke, AE; Mägi, R; Strawbridge, RJ; Pers, TH; Fischer, K; Justice, AE; Workalemahu, T; Wu, JM; Buchkovich, ML; Heard-Costa, NL; Roman, TS; Drong, AW; Song, C; Gustafsson, S; Day, FR; Esko, T ... Mohlke, KL. (2015). New genetic loci link adipose and insulin biology to body fat distribution. Nature, 518 (7538), 187−196. DOI: 10.1038/nature14132.
1.1.
2015
Locke, AE.; Kahali, B.; Berndt, SI.; Justice, AE.; Pers, TH.; Day, FR.; Powell, C.; Vedantam, S.; Buchkovich, ML.; Yang, J.; Croteau-Chonka, DC.; Esko, T.; Fall, T.; Ferreira, T.; Gustafsson, S.; Kutalik, Z.; Luan, J.; Mägi, R.; Randall, JC.; Winkler, TW. ... Speliotes, EK. (2015). Genetic studies of body mass index yield new insights for obesity biology. Nature, 518 (7538), 197−206. DOI: 10.1038/nature14177.
1.1.
2015
The, Coffee, and, Caffeine, Genetics, Consortium; Cornelis, MC; Byrne, EM; Esko, T; Nalls, MA; Ganna, A; Paynter, N; Monda, KL; Amin, N; Fischer, K; Renstrom, F; Ngwa, JS; Huikari, V; Cavadino, A; Nolte, IM; Teumer, A; Yu, K; Marques-Vidal, P; Rawal, R; Manichaikul, A ... Chasman, DI. (2015). Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Molecular Psychiatry, 20 (5), 647−656. DOI: 10.1038/mp.2014.107.
1.1.
2015
Winkler, Thomas W.; Justice, Anne E.; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F.; Chu, Su; Czajkowski, Jacek; Esko, Tonu; Fall, Tove; Kilpelainen, Tuomas O.; Lu, Yingchang; Magi, Reedik; Mihailov, Evelin; Pers, Tune H.; Rueeger, Sina; Teumer, Alexander; Ehret, Georg B.; Ferreira, Teresa; Heard-Costa, Nancy L.; Karjalainen, Juha ... Loos, Ruth J. F. (2015). The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genetics, 11 (10), ARTN e1005378. DOI: 10.1371/journal.pgen.1005378.
1.1.
2015
Saar, Aet; Marandi, Toomas; Ainla, Tiia; Fischer, Krista; Blöndal, Mai; Eha, Jaan (2015). Improved treatment and prognosis after acute myocardial infarction in Estonia: cross-sectional study from a high risk country. BMC Cardiovascular Disorders, 15 (1), 136. DOI: 10.1186/s12872-015-0129-7.
1.1.
2015
Zimmermann, E; Angquist, LH; Mirza, S S; Zhao, J H; Chasman, D I; Fischer, K; Qi, Q; Smith, A V; Thinggaard, M; Jarczok, M N; Nalls, M A; Trompet, S; Timpson, N J; Schmidt, B; Jackson, A U; Lyytikainen, L P; Verweij, N; Mueller-Nurasyid, M; Vikstrom, M; Marques-Vidal, P ... Sorensen, TIA. (2015). Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. Obesity Reviews, 16 (4), 327−340. DOI: 10.1111/obr.12263.
1.1.
2015
Haller, Toomas; Kals, Mart; Esko, Tonu; Maegi, Reedik; Fischer, Krista (2015). RegScan: a GWAS tool for quick estimation of allele effects on continuous traits and their combinations. Briefings in Bioinformatics, 16 (1), 39−44. DOI: 10.1093/bib/bbt066.
1.1.
2015
Hägg, S; Fall, T; Ploner, A; Mägi, R; Fischer, K; Draisma, HH; Kals, M; de Vries, PS; Dehghan, A; Willems, SM; Sarin, AP; Kristiansson, K; Nuotio, ML; Havulinna, AS; de Bruijn, RF; Ikram, MA; Kuningas, M; Stricker, BH; Franco, OH; Benyamin, B ... European, Network, for, Genetic, and, Genomic, Epidemiology, (ENGAGE) consortium. (2015). Adiposity as a cause of cardiovascular disease: a Mendelian randomization study. International Journal of Epidemiology, 44 (2), 578−586. DOI: 10.1093/ije/dyv094.
1.1.
2015
Leitsalu, Liis; Haller, Toomas; Esko, Tõnu; Tammesoo, Mari-Liis; Alavere, Helene; Snieder, Harold; Perola, Markus; Ng, Pauline C; Mägi, Reedik; Milani, Lili; Fischer, Krista; Metspalu, Andres (2015). Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu. International Journal of Epidemiology, 44 (4), 1137−1147. DOI: 10.1093/ije/dyt268.
1.1.
2015
Heesen, C.; Kasper, J.; Fischer, K.; Koepke, S.; Rahn, A.; Backhus, I.; Poettgen, J.; Vahter, L.; Drulovic, J.; Van Nunen, A.; Beckmann, Y.; Liethmann, K.; Giordano, A.; Fulcher, G.; Solari, A.; AutoMS-group (2015). Risk Knowledge in Relapsing Multiple Sclerosis (RIKNO 1.0) - Development of an Outcome Instrument for Educational Interventions. PLoS ONE, 10 (10), ARTN e0138364. DOI: 10.1371/journal.pone.0138364.
1.3.
2015
Saar, Aet; Marandi, Toomas; Alver, Maris; Ainla, Tiia; Fischer, Krista; Eha, Jaan (2015). Südame isheemiatõve riski ennustamine geneetiliste markerite abil [Coronary artery disease risk prediction using genetic markers]. Eesti Arst, 94 (9), 522−529.
1.3.
2015
Meren, Ülle Helena; Metspalu, Andres; Tammaru, Marika; Volmer, Daisy; Hedman, Anu; Alavere, Helene; Leitsalu, Liis; Läll, Kristi; Alver, Maris; Fischer, Krista (2015). Personaalse geneetilise riskiteabe mõju hüpertensiooniravi järgimusele ja tulemuslikkusele Eesti patsientidel: juhuslikustatud uuringu metoodika ülevaade. Eesti Arst, 94, 118−122.
3.4.
2015
Saar, Aet; Marandi, Toomas; Blöndal, Mai; Ainla, Tiia; Fischer, Krista; Eha, Jaan. (2015). Improved Treatment and Prognosis after Myocardial Infarction in Estonia between 2001 and 2011. Cardiology: XXV Nordic-Baltic Congress of Cardiology 2015, Tallinn, Estonia. Karger, 31−32.
3.5.
2015
Saar, Aet; Marandi, Toomas; Ainla, Tiia; Blöndal, Mai; Fischer, Krista; Eha, Jaan (2015). Impact of national PCI network on prognosis after acute myocardial infarction in Estonia. European Heart Journal: ESC, London, Suurbritannia, 2015. , 188. (36 (Abstract Supplement)).
5.1.
2015
Kaakinen, M.; Maegi, R.; Fischer, K.; Jarvelin, M. -R.; Morris, A. P.; Prokopenko, I. (2015). A Novel Method and Software Tool for Genome-Wide Multi-Phenotype Analysis of Rare Variants. Human Heredity, 79: 43rd European Mathematical Genetics Meeting (EMGM), Brest, FRANCE, APR 16-17, 2015. Karger, 39−39. (1).
5.1.
2015
Meren Ü.H., Akavere, H., Fischer, K., Leitsalu, L., Tammaru, M., Volmer, D. (2015). Improving medication adherence in hypertension patients through genetic risk assessment. International Journal of Clinical Pharmacy, 37: Nordic Social Pharmacy and Health services Research Conference & The Nordic Networking Group for Clinical Pharmacy June 3-5, 2015, Tartu, Estonia. Springer, 28−29. (Suppl.1).
5.1.
2015
Kaakinen, Marika; Magi, Reedik; Fischer, Krista; Jarvelin, Marjo-Riitta; Morris, Andrew P.; Prokopenko, Inga (2015). MARV: Anovel method and software tool for genome-wide multi-phenotype analysis of rare variants. Genetic Epidemiology, 39 (7), 560−560.
1.1.
2014
Wood, AR; Esko, T; Yang, J; Vedantam, S; Pers, TH; Gustafsson, S; Chu, AY; Estrada, K; Luan, J; Kutalik, Z; Amin, N; Buchkovich, ML; Croteau-Chonka, DC; Day, FR; Duan, Y14; Fall, T; Fehrmann, R; Ferreira, T; Jackson, AU; Karjalainen, J ... Frayling, TM. (2014). Defining the role of common variation in the genomic and biological architecture of adult human height. Nature Genetics, 46 (11), 1173−1186. DOI: 10.1038/ng.3097.
1.1.
2014
Wiles, NJ.; Fischer, K.; Cowen, P.; Nutt, D.; Peters, TJ.; Lewis, G.; White, IR. (2014). Allowing for non-adherence to treatment in a randomized controlled trial of two antidepressants (citalopram versus reboxetine): an example from the GENPOD trial. Psychological Medicine, 44 (13), 2855−2866. DOI: 10.1017/S0033291714000221.
1.1.
2014
Boraska, V; Franklin, CS; Floyd, JA; Thornton, LM; Huckins, LM; Southam, L; Rayner, NW; Tachmazidou, I; Klump, KL; Treasure, J; Lewis, CM; Schmidt, U; Tozzi, F; Kiezebrink, K; Hebebrand, J; Gorwood, P; Adan, RA; Kas, MJ; Favaro, A; Santonastaso, P ... Bulik, CM. (2014). A genome-wide association study of anorexia nervosa. Molecular Psychiatry, 19 (10), 1085−1094. DOI: 10.1038/mp.2013.187.
1.1.
2014
Auro, K; Joensuu, A; Fischer, K; Kettunen, J; Salo, P; Mattsson, H; Niironen, M; Kaprio, J; Eriksson, JG; Lehtimaki, T; Raitakari, O; Jula, A; Tiitinen, A; Jauhiainen, M; Soininen, P; Kangas, AJ; Kahonen, M; Havulinna, AS; Ala-Korpela, M; Salomaa, V ... Perola, M. (2014). A metabolic view on menopause and ageing. Nature Communications, 5 (4708), 1−11. DOI: 10.1038/ncomms5708.
1.1.
2014
Walsh, KM; Codd, V; Smirnov, IV; Rice, T; Decker, PA; Hansen, HM; Kollmeyer, T; Kosel, ML; Molinaro, AM; McCoy, LS; Bracci, PM; Cabriga, BS; Pekmezci, M; Zheng, SC; Wiemels, JL; Pico, AR; Tihan, T; Berger, MS; Chang, SM; Prados, MD ... ENGAGE, Consortium, Teleomere, Grp. (2014). Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nature Genetics, 46 (7), 731−735. DOI: 10.1038/ng.3004.
1.1.
2014
Hoggart, CJ; Venturini, G; Mangino, M; Gomez, F; Ascari, G; Zhao, JH; Teumer, A; Winkler, TW; Tsernikova, N; Luan, J; Mihailov, E; Ehret, GB; Zhang, W; Lamparter, D; Esko, T; Mace, A; Rueger, S; Bochud, P-Y; Barcella, M; Dauvilliers, Y ... Kutalik, Z. (2014). Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index. PLoS Genetics, 10 (7), e1004508. DOI: 10.1371/journal.pgen.1004508.
1.1.
2014
Winkler, T.W.; Day, FR.; Croteau-Chonka, DC.; Wood, AR.; Locke, AE.; Magi, R.; Ferreira, T.; Fall, T.; Graff, M.; Justice, AE.; Luan, JA.; Gustafsson, S.; Randall, JC.; Vedantam, S.; Workalemahu, T.; Kilpelainen, TO.; Scherag, A.; Esko, T.; Kutalik, Z.; Heid, IM. ... Loos, RJF (2014). Quality control and conduct of genome-wide association meta-analyses. Nature Protocols, 9 (5), 1192−1212. DOI: 10.1038/nprot.2014.071.
1.1.
2014
Deelen, J; Beekman, M; Uh, HW; Broer, L; Ayers, KL; Tan, Q; Kamatani, Y; Bennet, AM; Tamm, R; Trompet, S; Guðbjartsson, DF; Flachsbart, F; Rose, G; Viktorin, A; Fischer, K; Nygaard, M; Cordell, HJ; Crocco, P; van den Akker, EB; Böhringer, S ... Slagboom, PE. (2014). Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Human Molecular Genetics, 23 (16), 4420−4432. DOI: 10.1093/hmg/ddu139.
1.1.
2014
van Vliet-Ostaptchouk, JV; Nuotio, ML; Slagter, SN; Doiron, D; Fischer, K; Foco, L; Gaye, A; Gögele, M; Heier, M; Hiekkalinna, T; Joensuu, A; Newby, C; Pang, C; Partinen, E; Reischl, E; Schwienbacher, C; Tammesoo, ML; Swertz, MA; Burton, P; Ferretti, V ... Wolffenbuttel, BH (2014). The prevalence of metabolic syndrome and metabolically healthy obesity in Europe: a collaborative analysis of ten large cohort studies. BMC Endocrine Disorders, 14 (9), 1−13. DOI: 10.1186/1472-6823-14-9.
1.1.
2014
Fischer, K.; Kettunen, J.; Würtz, P.; Haller, T.; Aki S. Havulinna, A.S.; Kangas, A.J.; Soininen, P.; Esko, T.; Tammesoo, M-L.; Mägi, R.; Smit, S.; Palotie, A.; SRipatti, S.; Veikko Salmaa, V.; Ala-Korpela, M.; Perola, M.; Metspalu, A. (2014). Biomarker Profiling by Nuclear Magnetic Resonance Spectroscopy for the Prediction of All-Cause Mortality: An Observational Study of 17,345 Persons. PLoS Medicine, 11 (2), e1001606. DOI: 10.1371/journal.pmed.1001606.
1.1.
2014
Deelen, J.; Beekman, M.; Codd, V.; Trompet, S.; Broer, L.; Hägg, S.; Fischer, K.; Thijssen, P.E.; Suchiman, H.E.; Postmus, I.; Uitterlinden, A.G.; Hofman, A.; de, Craen, A.J.; Metspalu, A.; Pedersen, NL.; van, Duijn, CM.; Wouter, Jukema, J.; Houwing-Duistermaat, JJ.; Samani, NJ.; Slagboom, EP. (2014). Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers. International Journal of Epidemiology, 43 (3), 878−886. DOI: 10.1093/ije/dyt267.
1.2.
2014
Fischer K., Berry, D. (2014). Statisticians Introduce Science to International Doping Agency: The Andrus Veerpalu Case. Chance, 27, 3.
1.1.
2013
Global, Lipids, Genetics, Consortium; Willer, CJ; Schmidt, EM; Sengupta, S; Peloso, GM; Gustafsson, S; Kanoni, S; Ganna, A; Chen, J; Buchkovich, ML; Mora, S; Beckmann, JS; Bragg-Gresham, JL; Chang, HY; Demirkan, A; Den, Hertog, HM; Do, R; Donnelly, LA; Ehret, GB; Esko, T ... Abecasis, GR. (2013). Discovery and refinement of loci associated with lipid levels. Nature Genetics, 45 (11), 1274−1283. DOI: 10.1038/ng.2797.
1.1.
2013
Do, R; Willer, CJ; Schmidt, EM; Sengupta, S; Gao, C; Peloso, GM; Gustafsson, S; Kanoni, S; Ganna, A; Chen, J; Buchkovich, ML; Mora, S; Beckmann, JS; Bragg-Gresham, JL; Chang, HY; Demirkan, A; Den, Hertog, HM; Donnelly, LA; Ehret, GB; Esko, T ... Kathiresan, S. (2013). Common variants associated with plasma triglycerides and risk for coronary artery disease. Nature Genetics, 45 (11), 1345−1352 . DOI: 10.1038/ng.2795.
1.1.
2013
Westra, HJ; Peters, MJ; Esko, T; Yaghootkar, H; Schurmann, C; Kettunen, J; Christiansen, MW; Fairfax, BP; Schramm, K; Powell, JE; Zhernakova, A; Zhernakova, DV; Veldink, JH; Van den Berg, LH; Karjalainen, J; Withoff, S; Uitterlinden, AG; Hofman, A; Rivadeneira, F; 't Hoen, PA ... Franke, L. (2013). Systematic identification of trans eQTLs as putative drivers of known disease associations. Nature Genetics, 45 (10), 1238−U195. DOI: 10.1038/ng.2756.
1.1.
2013
Tammiste, Anu; Jiang, Tao; Fischer, Krista; Mägi, Reedik; Krjutškov, Kaarel; Pettai, Kristi; Esko, Tõnu; Li, Yingrui; Tansey, Katherine E; Carroll, Liam S; Uher, Rudolf; McGuffin, Peter; Võsa, Urmo; Tšernikova, Natalia; Saria, Alois; Ng, Pauline C; Eller, Triin; Vasar, Veiko; Nutt, David J; Maron, Eduard ... Metspalu, Andres (2013). Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression. Journal of Psychopharmacology, 27 (10), 915−920. DOI: 10.1177/0269881113499829.
1.1.
2013
Fall, T.; Hagg, S.; Magi, R.; Ploner, A.; Fischer, K.; Horikoshi, M.; Sarin, AP.; Thorleifsson, G.; Ladenvall, C.; Kals, M.; Kuningas, M.; Draisma, HHM.; Ried, JS.; van Zuydam, NR.; Huikari, V.; Mangino, M.; Sonestedt, E.; Benyamin, B.; Nelson, CP.; Rivera, NV. ... Prokopenko, I. (2013). The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis. PLoS Medicine, 10 (6), e1001474−e1001474. DOI: 10.1371/journal.pmed.1001474.
1.1.
2013
Rietveld, CA; Medland, SE; Derringer, J; Yang, J; Esko, T; Martin, NW; Westra, HJ; Shakhbazov, K; Abdellaoui, A; Agrawal, A; Albrecht, E; Alizadeh, BZ; Amin, N; Barnard, J; Baumeister, SE; Benke, KS; Bielak, LF; Boatman, JA; Boyle, PA; Davies, G ... Koellinger, PD. (2013). GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment. Science, 340 (6139), 1467−1471. DOI: 10.1126/science.1235488.
1.1.
2013
den Hoed, M; Eijgelsheim, M; Esko, T; Brundel, BJ; Peal, DS; Evans, DM; Nolte, IM; Segrè, AV; Holm, H; Handsaker, RE; Westra, HJ; Johnson, T; Isaacs, A; Yang, J; Lundby, A; Zhao, JH; Kim, YJ; Go, MJ; Almgren, P; Bochud, M ... Loos, RJ. (2013). Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders. Nature Genetics, 45 (6), 621.
1.1.
2013
Berndt, SI; Gustafsson, S; Mägi, R; Ganna, A; Wheeler, E; Feitosa, MF; Justice, AE; Monda, KL; Croteau-Chonka, DC; Day, FR; Esko, T; Fall, T; Ferreira, T; Gentilini, D; Jackson, AU; Luan, J; Randall, JC; Vedantam, S; Willer, CJ; Winkler, TW ... Ingelsson, E. (2013). Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nature Genetics, 45 (5), 501−U69. DOI: 10.1038/ng.2606.
1.1.
2013
Codd, V; Nelson, CP; Albrecht, E; Mangino, M; Deelen, J; Buxton, JL; Hottenga, JJ; Fischer, K; Esko, T; Surakka, I; Broer, L; Nyholt, DR; Leach, IM; Salo, P; Hägg, S; Matthews, MK; Palmen, J; Norata, GD; O'Reilly, PF; Saleheen, D ... Samani, NJ (2013). Identification of seven loci affecting mean telomere length and their association with disease. Nature Genetics, 45 (4), 422−427. DOI: 10.1038/ng.2528.
1.1.
2013
Perry, JR; Corre, T; Esko, T; Chasman, DI; Fischer, K; Franceschini, N; He, C; Kutalik, Z; Mangino, M; Rose, LM; Smith, AV; Stolk, L; Sulem, P; Weedon, MN; Zhuang, WV; Arnold, A; Ashworth, A; Bergmann, S; Buring, JE; Burri, A ... Murray, A (2013). A genome-wide association study of early menopause and the combined impact of identified variants. Human Molecular Genetics, 22(7) (1), 1465−1472. DOI: 10.1093/hmg/dds551.
1.1.
2013
Deloukas, P; Kanoni, S; Willenborg, C; Farrall, M; Assimes, TL; Thompson, JR; Ingelsson, E; Saleheen, D; Erdmann, J; Goldstein, BA; Stirrups, K; König, IR; Cazier, JB; Johansson, A; Hall, AS; Lee, JY; Willer, CJ; Chambers, JC; Esko, T; Folkersen, L ... Samani, NJ (2013). Large-scale association analysis identifies new risk loci for coronary artery disease. Nature Genetics, 45 (1), 25−33. DOI: 10.1038/ng.2480.
1.1.
2013
Randall, JC; Winkler, TW; Kutalik, Z; Berndt, SI; Jackson, AU; Monda, KL; Kilpeläinen, TO; Esko, T; Mägi, R; Li, S; Workalemahu, T; Feitosa, MF; Croteau-Chonka, DC; Day, FR; Fall, T; Ferreira, T; Gustafsson, S; Locke, AE; Mathieson, I; Scherag, A ... Heid, IM (2013). Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits. PLoS Genetics, 9 (6), e1003500. DOI: 10.1371/journal.pgen.1003500.
1.1.
2013
Vimaleswaran, KS.; Berry, DJ.; Lu, C.; Tikkanen, E.; Pilz, S.; Hiraki, LT.; Cooper, JD.; Dastani, Z.; Li, R.; Houston, DK.; Wood, AR.; Michaëlsson, K.; Vandenput, L.; Zgaga, L.; Yerges-Armstrong, LM.; McCarthy, MI.; Dupuis, J.; Kaakinen, M.; Kleber, ME.; Jameson, K. ... Hyppönen, E. (2013). Causal relationship between obesity and vitamin D status: bi-directional Mendelian randomization analysis of multiple cohorts. PLoS Medicine, 10 (2), e1001383. DOI: 10.1371/journal.pmed.1001383.
5.2.
2013
Meren, Ü.H.; Alavere, H.; Fischer, K.; Leitsalu, L.; Tammaru, M.; Volmer, D. (2013). Genetic risk assessment as a tool for improving medication adherence in hypertension patients. 17th Annual ESPACOMP Meeting. Book of abstracts: 17th Annual ESPACOMP Meeting; Budapest, Hungary; 15-16 Nov 2013. ESPACOMP, 68.
1.1.
2012
van der Harst, P.; Zhang, W.; Mateo Leach, I.; Rendon, A.; Verweij, N.; Sehmi, J.; Paul, DS.; Elling, U.; Allayee, H.; Li, X.; Radhakrishnan, A.; Tan, ST.; Voss, K.; Weichenberger, CX.; Albers, CA.; Al-Hussani, A.; Asselbergs, FW.; Ciullo, M.; Danjou, F.; Dina, C. ... Chambers, JC. (2012). Seventy-five genetic loci influencing the human red blood cell. Nature, 492 (7429), 369−375. DOI: 10.1038/nature11677.
1.1.
2012
Yang, J; Loos, RJ; Powell, JE; Medland, SE; Speliotes, EK; Chasman, DI; Rose, LM; Thorleifsson, G; Steinthorsdottir, V; Mägi, R; Waite, L; Vernon, Smith, A; Yerges-Armstrong, LM; Monda, KL; Hadley, D; Mahajan, A; Li, G; Kapur, K; Vitart, V; Huffman, JE ... Visscher, PM (2012). FTO genotype is associated with phenotypic variability of body mass index. Nature, 490 (7419), 267−272. DOI: 10.1038/nature11401.
1.1.
2012
McQuillan, R.; Eklund, N.; Pirastu, N.; Kuningas, M.; McEvoy, BP.; Esko, T.; Corre, T.; Davies, G.; Kaakinen, M.; Lyytikäinen, LP.; Kristiansson, K.; Havulinna, AS.; Gögele, M.; Vitart, V.; Tenesa, A.; Aulchenko, Y.; Hayward, C.; Johansson, A.; Boban, M.; Ulivi, S. ... on behalf of the ROHgen, Consortium. (2012). Evidence of Inbreeding Depression on Human Height. PLoS Genetics, 8 (7), e1002655. DOI: 10.1371/journal.pgen.1002655.
1.1.
2012
Boraska, V; Jeroncic, A; Colonna, V; Southam, L; Nyholt, DR; William, Rayner, N; Perry, JR; Toniolo, D; Albrecht, E; Ang, W; Bandinelli, S; Barbalic, M; Barroso, I; Beckmann, JS; Biffar, R; Boomsma, D; Campbell, H; Corre, T; Erdmann, J; Esko, T ... Zeggini, E (2012). Genome-wide meta-analysis of common variant differences between men and women. Human Molecular Genetics, 4805−4815. DOI: 10.1093/hmg/dds304.
1.1.
2012
the DIAbetes Genetics Replication And Meta-analysis (DIAGRAM), Consortium; Morris, AP; Voight, BF; Teslovich, TM; Ferreira, T; Segrè, AV; Steinthorsdottir, V; Strawbridge, RJ; Khan, H; Grallert, H; Mahajan, A; Prokopenko, I; Kang, HM; Dina, C; Esko, T; Fraser, RM; Kanoni, S; Kumar, A; Lagou, V; Langenberg, C ... McCarthy, MI. (2012). Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nature Genetics, 981−990. DOI: 10.1038/ng.2383.
1.1.
2012
Lokk, Kaie; Vooder, Tõnu; Kolde, Raivo; Välk, Kristjan; Võsa, Urmo; Roosipuu, Retlav; Milani, Lili; Fischer, Krista; Koltšina, Marina; Urgard, Egon; Annilo, Tarmo; Metspalu, Andres; Tõnisson, Neeme (2012). Methylation Markers of Early-Stage Non-Small Cell Lung Cancer. PLoS ONE, 7 (6), e39813− . DOI: 10.1371/journal.pone.0039813.
1.1.
2012
Veerus, P.; Fischer, K.; Hakama, M.; Hemminki, E. (2012). Results from a blind and a non-blind randomised trial run in parallel: experience from the Estonian Postmenopausal Hormone Therapy (EPHT) Trial. BMC Medical Research Methodology, 12, 44. DOI: 10.1186/1471-2288-12-44.
1.1.
2012
Stolk, L.; Perry, JR.; Chasman, DI.; He, C.; Mangino, M.; Sulem, P.; Barbalic, M.; Broer, L.; Byrne, EM.; Ernst, F.; Esko, T.; Franceschini, N.; Gudbjartsson, DF.; Hottenga, JJ.; Kraft, P.; McArdle, PF.; Porcu, E.; Shin, SY.; Smith, AV.; van Wingerden, S. ... Lunetta, KL. (2012). Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. Nature Genetics, 44 (3), 260−268. DOI: 10.1038/ng.1051.
1.3.
2012
Alavere, H; Fischer, K; Esko, T; Leitsalu-Moynihan, L; Metspalu, A (2012). Tartu Ülikooli Eesti geenivaramu on teadlaste käsutuses [The Estonian Genome Center of the University of Tartu at the disposal of scientists]. Eesti Arst, 91 (4), 190−198.
5.2.
2012
Tõnisson, N.; Lokk, K.; Vooder, T.; Kolde, R.; Välk, K.; Roosipuu, R.; Võsa, U.; Milani, L.; Fischer, K.; Koltšina, M.; Urgard, E.; Annilo, T.; Metspalu, A. (2012). Altered DNA methylation in early-stage non-small-cell lung cancer. European Journal of Human Genetics: European Human Genetics Conference; Nürnberg, Saksamaa; 23.–26. juuni, 2012. Nature Publishing Group, 174−174. (20; Suppl 1).
6.7.
2012
Kaasik, Aidula-Taie; Keis, Aime; Metspalu, Andres; Allik, Annely; Mölder, Ene; Leego, Erkki; Alavere, Helene; Lilienthal, Kadri Fischer, Krista; Leitsalu-Moynihan, Liis; Milani, Lili; Tammesoo, Mari-Liis; Väli-Täht, Maris; Leego, Merike; Hass, Merli; Tamm, Riin; Nikopensius, Tiit; Esko, Tõnu; Haller, Toomas (2012). Estonian Genome Center : 2001-2011. Tartu: University of Tartu.
1.1.
2011
Võsa, Urmo; Vooder, Tõnu; Kolde, Raivo; Fischer, Krista; Välk, Kristjan; Tõnisson, Neeme; Roosipuu, Retlav; Vilo, Jaak; Metspalu, Andres; Annilo, Tarmo (2011). Identification of miR-374a as a prognostic marker for survival in patients with early-stage nonsmall cell lung cancer. Genes Chromosomes and Cancer, 50 (10), 812−822. DOI: 10.1002/gcc.20902.
1.1.
2011
Fischer, K.; Goetghebeur, E.; Vrijens, B.; White, I. (2011). A structural mean model to allow for noncompliance in a randomized trial comparing 2 active treatments . Biostatistics, 12 (2), 247−257. DOI: 10.1093/biostatistics/kxq053.
3.2.
2011
Metspalu, A.; Leitsalu, L.; Milani, L.; Esko, T.; Allik, A.; Lilienthal, M.-L.; Haller, T.; Kaasik, A.-T.;Nelis, M.; Hass, M.; Fischer, K.; Krjutškov, K.; Leego, E.; Alavere, H.; Perola, M. (2011). The Estonian biobank - the gateway for the stratified medicine. In: Engelbrecht, J. (Ed.). Research in Estonia. Present and future. (283−301). . Tallinn: Estonian Academy of Sciences.
1.3.
2009
Fischer K, Veerus P, Rahu M. (2009). Postmenopausis naiste tervise enesehinnangu ja elukvaliteedi seos [Relationship between subjective well-being and quality of life in postmenopausal women.]. Eesti Arst, 12, 790−796.
1.1.
2008
Uusküla, A.; Fischer, K.; Raudne, R.; Kilgi, H.; Krylov, R.; Salminen, M.; Brummer-Korvenkontio, H.; St Lawrence, J.; Aral, S. (2008). A study on HIV and hepatitis C virus among commercial sex workers in Tallinn. Sexually Transmitted Infections, 84 (3), 189−191. DOI: 10.1136/sti.2007.027664.
1.2.
2008
Veerus, P.; Fischer, K.; Hovi, S.L.; Karro, H.; Rahu, M.; Hemminki, E. (2008). Symptom reporting and quality of life in the Estonian Postmenopausal Hormone Therapy Trial. BMC Women's Health, 8, 5. DOI: 10.1186/1472-6874-8-5.
1.1.
2007
Liskmann, S.; Vihalemm, T.; Salum, O.; Zilmer, K.; Fischer, K.; Zilmer, M. (2007). Characterization of the antioxidant profile of human saliva in peri-implant health and disease. Clinical Oral Implants Research, 18 (1), 27−33. DOI: 10.1111/j.1600-0501.2006.01296.x.
1.1.
2007
Veerus, P.; Fischer, K.; Hovi, S.L.; Karro, H.; Hemminki, E. (2007). Does hormone replacement therapy affect the use of prescription medicines in postmenopausal women: experience from the Estonian Postmenopausal Hormone Therapy Trial [ISRCTN35338757]. BJOG: An International Journal of Obstetrics & Gynaecology, 114 (5), 548−554. DOI: 10.1111/j.1471-0528.2007.01292.x.
1.1.
2007
Viru, A.; Viru, M.; Karelson, K.; Janson, T.; Siim, K.; Fischer, K.; Hackney, A.C. (2007). Adrenergic effects on adrenocortical cortisol response to incremental exercise to exhaustion. European Journal of Applied Physiology, 100 (2), 241−245.
1.1.
2007
Uusküla, A.; McNutt, L.A.; Dehovitz, J.; Fischer, K.; Heimer, R. (2007). High prevalence of blood-borne virus infections and high-risk behaviour among injecting drug users in Tallinn, Estonia. International Journal of STD & AIDS, 18 (1), 41−46.
1.1.
2007
Kiive, E.; Fischer, K.; Harro, M.; Harro, J. (2007). Platelet monoamine oxidase activity in association with adolescent inattentive and hyperactive behaviour: A prospective longitudinal study. Personality and Individual Differences, 43, 155−166.
1.1.
2007
Sterne, J.A.C.; May, M.; Sabin, C.; Phillips, A.; Costagliola, D.; Chêne, G.; Justice, A.C.; De Wolf, F.; Hogg, R.; Battegay, M.; Monforte, A.D.; Fa, G.; Staszewski, S.; Gill, J.; Egger, M.; Casabona, J.; Dabis, F.; Kitahata, M.; Leport, C.; Lundgren, J. ... Wohrmann, A. (2007). Importance of Baseline Prognostic Factors With Increasing Time Since Initiation of Highly Active Antiretroviral Therapy: Collaborative Analysis of Cohorts of HIV-1-Infected Patients. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 46 (5), 607−615.
1.3.
2007
Veerus P., Fischer K., Rahu M., Karro H., Hovi SL., Hemminki E. (2007). Hormoonravi efekt vereringehaiguste, luumurdude ja vähi esinemisele: juhuslikustatud kliiniline uuring EPHT [ISRCTN35338757] postmenopausis Eesti naiste hulgas. Eesti Arst, 86 (7), 441−449.
1.3.
2007
Veerus, P.; Fischer, K.; Rahu, M.; Karro, H.; Hovi, S.-L.; Hemminki, E. (2007). Hormoonravi efekt vereringehaiguste, luumurdude ja vähi esinemisele: juhuslikustatud kliiniline uuring EPHT [ISRCTN35338757] postmenopausis Eesti naiste hulgas. Eesti Arst, 86 (7), 441−448.
1.1.
2006
Muda, P.; Kampus, P.; Teesalu, R.; Zilmer, K.; Ristimäe, T.; Fischer, K.; Zilmer, M. (2006). Effects of amlodipine and candesartan on oxidized low-density lipoprotein level in patients with mild to moderate essential hypertension. Blood Pressure, 15 (5), 313−318.
1.1.
2006
Veerus, P.; Hovi, S.L.; Fischer, K.; Rahu, M.; Hakama, M.; Hemminki, E. (2006). Results from the Estonian postmenopausal hormone therapy trial [ISRCTN35338757]. Maturitas, 55 (2), 162−173.
1.1.
2006
Veerus, P.; Fischer, K.; Hovi, S.L.; Hakama, M.; Rahu, M.; Hemminki, E. (2006). Postmenopausal hormone therapy increases use of health services: experience from the Estonian Postmenopausal Hormone Therapy Trial [ISRCTN35338757]. American Journal of Obstetrics and Gynecology, 195 (1), 62−71.
1.1.
2006
Kampus, P.; Muda, P.; Kals, J.; Ristimäe, T.; Fischer, K.; Teesalu, R.; Zilmer, M. (2006). The relationship between inflammation and arterial stiffness in patients with essential hypertension. International Journal of Cardiology, 112 (1), 46−51.
1.1.
2006
Uuskula, A.; Heimer, R.; DeHovitz, J.; Fischer, K.; McNutt, LA. (2006). Surveillance of HIV, hepatitis B virus, and hepatitis c virus in an Estonian injection drug-using population: Sensitivity and specificity of testing syringes for public health surveillance. The Journal of Infectious Diseases, 193 (3), 455−457.
1.2.
2006
Raal, A.; Fischer, K.; Irs, A. (2006). Determination of drug information needs of health care professionals in Estonia. Medicina (Kaunas), 42 (12), 1030−1034.
1.3.
2006
Toom, A.; Möls, M.; Fischer, K.; Veske, K.; Uibo, R.; Haviko, T.; Rips, L.; Arend, A.; Märtson, A. (2006). Hinnangute kokkulangevus ortopeedilises röntgendiagnostikas. Eesti Arst, 85, 54−58.
3.4.
2006
Ulber, B.; Fischer, K.; Klukowski, Z.; Luik, A.; Veromann, E.; Nilsson, C.; Ahman, B.; Williams, I.; Ferguson, A.; Barari, H. (2006). Identity and potential of parasitoids for oilseed rape pests in Europe. Proceedings of International Symposium on Integrated Pest Management in Oilseed Rape: International Symposium on Integrated Pest Management in Oilseed Rape, 3-5 April, 2006, Göttingen, Germany. Ed. Alford, David.
6.3.
2006
Fischer, K.; Kollo, T.; Lember, J.; Tiit, E.-M. (2006). Matemaatilise statistika ja tõenäosusteooria alastest uuringutest Eestis. Koppel, I.; Saari, P. (Toim.). Teadusmõte Eestis: Täppisteadused (147−152). . Tallinn: Eesti Teaduste Akadeemia.
1.1.
2005
Muda, P.; Kampus, P.; Zilmer, A. ; Ristimae, T.; Fischer, K.; Zilmer, K.; Kairane, C.; Teesalu, R. (2005). Effect of antihypertensive treatment with candesartan or amlodipine on glutathione and its redox status, homocysteine and vitamin concentrations in patients with essential hypertension. Journal of Hypertension, 23 (1), 105−112.
1.1.
2005
Toom, A.; Fischer, K.; Martson, A.; Rips, L.; Haviko, T. (2005). Inter-observer reliability in the assessment of heterotopic ossification: proposal of a combined classification. International Orthopaedics, 29 (3), 156−159.
2.5.
2005
Uusküla, Anneli; Abel, Katri; Rajaleid, Kristiina; Rüütel, Kristi; Talu, Ave; Fischer, Krista; Boborova, Natalia (2005). HIV levimuse ja riskikäitumise uuring Eesti kahe linna (Tallinna ja Kohtla-Järve) süstivate narkomaanide seas. 1−34.
3.4.
2005
Fischer, K.; Pisarev, H.; Veerus, P. (2005). Methodological challenges in the analysis of randomized study with complicated design and low adherence rates. International Biometric Society, Nordic Regional Conference, June 2-4, 2005, Oslo, Norway.
5.1.
2005
Muda, R.; Kampus, P.; Teesalu, R.; Zilmer, K.; Ristimae, T.; Fischer, K.; Zilmer, M. (2005). Effects of candesartan and amlodipine on oxidized low-density lipoprotein level in patients with mild to moderate essential hypertension. Journal of Hypertension, 23, S68−S68.
1.1.
2004
Harro, J.; Fischer, K.; Vansteelandt, S.; Harro, M. (2004). Both low and high activities of platelet monoamine oxidase increase the probability of becoming a smoker. European Neuropsychopharmacology, 14 (1), 65−69.
1.1.
2004
Liskmann, S.; Zilmer, M.; Vihalemm, T.; Salum, O.; Fischer, K. (2004). Correlation of peri-implant health and myeloperoxidase levels: a cross-sectional clinical study. Clinical Oral Implants Research, 15 (5), 546−552.
1.1.
2004
Fischer, K.; Goetghebeur, E. (2004). Structural mean effects of noncompliance: Estimating interaction with baseline prognosis and selection effects. Journal of the American Statistical Association, 99 (468), 918−928.
1.1.
2004
Kampus, P.; Kals, J.; Ristmae, T.; Fischer, K.; Zilmer, M.; Teesalu, R. (2004). High-sensitivity C-reactive protein affects central haemodynamics and augmentation index in apparently healthy persons. Journal of Hypertension, 22 (6), 1133−1139.
1.1.
2004
Ledergerber, B.; Lundgren, J.D.; Sarah Walker, A.; Sabin, C.; Justice, A.; Reiss, P.; Mussini, C.; Wit, F.; d'Arminio Monforte, A.; Weber, R.; Fusco, G.; Staszewski, S.; Law, M.; Hogg, R.; Lampe, F.; John Gill, M.; Castelli, F.; Phillips, A.N.; Rooney, P.; Taylor, S. ... Esposito, R. (2004). Predictors of trend in CD4-positive T-cell count and mortality among HIV-1-infected individuals with virological failure to all three antiretroviral-drug classes (Lancet). The Lancet, 364 (9428), 51−62.
5.1.
2004
Muda, P.; Kampus, P.; Zilmer, M.; Fischer, K.; Ristimae, I.; Zilmer, K.; Kairane, C.; Teesalu, R. (2004). Antihypertensive treatment - Homocysteine, folic acid and glutathione status. Journal of Hypertension, 22, S94−S95.
5.2.
2004
Kirsimägi, Ülle; Lõhmus, Aleksdander; Lõhmus, Karina; Ilmoja, Madis; Kahu, Jaanus; Peetsalu, Ants; Fischer, Krista (2004). The results of kidney transplantation in Estonia: Patient and graft survival and patient assessment of their health status. XXII International Biometric Conference,Cairns, Queensland, Australia 11.-16.07.2004. Ed. International Biometric Society., 470−470.
1.1.
2003
Muda, P.; Kampus, P.; Zilmer, M.; Zilmer, K.; Kairane, C.; Ristimae, T.; Fischer, K.; Teesalu, R. (2003). Homocysteine and red blood cell glutathione as indices for middle-aged untreated essential hypertension patients. Journal of Hypertension, 21 (12), 2329−2333.
1.1.
2003
Pärna, K.; Rahu, K.; Fischer, K.; Mussalo-Rauhamaa, H.; Zhuravleva, I.; Umbleja, T.; Rahu, M. (2003). Smoking and associated factors among adolescents in Tallinn, Helsinki and Moscow: a multilevel analysis. Scandinavian Journal of Public Health, 31 (5), 350−358.
5.2.
2003
Fischer, K.; Ringmets, I.; Meiesaar, K. (2003). Torasemiidi kasutamine kroonilise südamepuudulikkuse ravis. Farmakoökonoomiline hinnang. Eesti Arst, 82 (9), 40−41.
3.4.
2001
Pisarev, H.; Fischer, K.; Goetghebeur, E. (2001). Structural Nested Mean Models in a Repeated Measures Setting. International Society for Clinical Biostatistics 22nd Annual Conference, Stockholm, 19.-23.august 2001, Abstracts: International Society for Clinical Biostatistics 22nd Annual Conference, Stockholm, 19.-23.august 2001. , 202−202.
1.1.
1999
Fischer-Lapp, K.; Goetghebeur, E. (1999). Practical properties of some structural mean analyses of the effect of compliance in randomized trials. Controlled Clinical Trials, 20 (6), 531−546.
1.1.
1998
Lapp, K.; Molenberghs, G.; Lesaffre, E. (1998). Models for the association between ordinal variables. Computational Statistics & Data Analysis, 28 (4), 387−411.
1.1.
1997
Goetghebeur, E.; Lapp, K. (1997). The effect of treatment compliance in a placebo-controlled trial: Regression with unpaired data. Journal of the Royal Statistical Society Series C (Applied Statistics), 46 (3), 351−364.
5.1.
1994
Genicot, B.; Lapp, K.; Close, R.; Lindsey, JK.; Lambert, P.; Lekeux, P. (1994). Physical-properties of drug particles generated, under different high working pressures, by equipment for delivering atomized drug in calves. Pflugers Archiv-European Journal of Physiology, 427, R63−R63.
24.03.2022