Anne Kuusksalu

https://www.etis.ee/CV/Anne_Kuusksalu/est
26.07.1959
6204432
anne.kuusksalu@ttu.ee

Teenistuskäik

Töökohad ja ametid
2005–31.12.2016   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool, Vanemteadur (1,00)
01.01.2004–31.12.2007   
Keemilise ja Bioloogilise Füüsika Instituut, molekulaargeneetika labor, vanemteadur
01.01.1986–31.12.2004   
Keemilise ja Bioloogilise Füüsika Instituut, molekulaargeneetika labor, teadur
01.01.1982–31.12.1986   
Eksperimentaalbioloogia Instituut, molekulaarbioloogia labor, nooremteadur
 
 
Haridustee
Tartu Riiklik Ülikool, füüsika-keemiateaduskond, 1982

Kvalifikatsioon

Teaduskraadid
Anne Kuusksalu, doktorikraad, 2003, (juh) Merike Kelve, 2-5A süntetaas merekäsnas Geodia Cydonium, Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.1. Biokeemia
 
 
Lisainfo
Ph.D.
Tallinna Tehnikaülikool, 2003

Lõppenud projektid

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2014
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Hansen Kjaer, Karina; Justesen, Just; Kelve, Merike (2014). Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage. Biochimie, 97, 200−209.10.1016/j.biochi.2013.10.015.
1.1.
2012
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; de Rosa, Salvatore; Kelve, Merike (2012). A novel endoribonuclease from the marine sponge Tethya aurantium specific to 2',5'-phosphodiester bond. Biochimie, 94, 1635−1646.10.1016/j.biochi.2012.04.002.
1.1.
2011
Vallmann, Kerli; Aas, Nele; Reintamm, Tõnu; Lopp, Annika; Kuusksalu, Anne; Kelve, Merike (2011). Expressed 2-5A synthetase genes and pseudogenes in the marine sponge Geodia barretti. Gene, 478, 42−49.10.1016/j.gene.2011.01.014.
1.1.
2010
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; Tammiste, Indrek; Pihlak, Arno; Kelve, Merike (2010). Natural Occurrence of 2′,5′-Linked Heteronucleotides in Marine Sponges. Marine Drugs, 8, 235−254.10.3390/md8020235.
5.1.
2009
Kuusksalu, A.; Lopp, A.; Päri, M.; Reintamm, T.; Kelve, M. (2009). Interferon-induced 2',5'-oligoadenylate synthetases versus those from sponges, evolutionarily lowest multicellyular animals. Cytokine, 48: Tri-Society Annual Conference 2009 of SLB, ICS and ISICR: Cellular and Cytokine Interactions in Health and Disease. Lisbon, Portugal. _EditorsAbbr Sir Gordon W. Duff; Scott K. Durum. Oxford, UK: Elsevier, 85−86. (1-2).10.1016/j.cyto.2009.07.308.
1.1.
2008
Reintamm, Tõnu; Kuusksalu, Anne; Metsis, Madis; Päri, Mailis; Vallmann, Kerli; Lopp, Annika; Justesen, Just; Kelve, Merike (2008). Sponge OAS has a distinct genomic structure within the 2-5A synthetase family. Molecular Genetics and Genomics, 280, 453−466.10.1007/s00438-008-0379-5.
1.1.
2007
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Reintamm, Tõnu; Justesen, Just; Kelve, Merike (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge < EM >Geodia cydonium< /EM >. FEBS Journal, 274, 3462−3474.10.1111/j.1742-4658.2007.05878.x.
1.3.
2007
Kuusksalu, Anne; Metsis, Madis; Reintamm, Tõnu; Kelve, Merike (2007). Construction and characterization of a cDNA library from the marine sponge Chondrosia reniformis. In: Custodio, M.R.; Lobo-Hajdu, G.; Hajdu, E.; Muricy, G (_EditorsAbbr). Porifera Research - Biodiversity, Innovation and Sustainability (405−412).. Rio de Janeiro: Museu Nacional. (Serie Livros).
5.1.
2007
Lopp, A.; Päri, M.; Kuusksalu, A.; Reintamm, T.; Justesen, J.; Kelve, M. (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge< EM > Geodia cydonium< /EM >. Journal of Interferon & Cytokine Reseach, 27: International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (50th Anniversary of the Discovery of Interferon), Sept. 16-19, 2007, Oxford, England. Mary Ann Liebert Inc, 719.
1.3.
2006
Roovere, T.; Lopp, A.; Reintamm, T.; Kuusksalu, A.; Richelle-Maurer, E.; Kelve, M. (2006). Freshwater sponges in Estonia: genetic and morphological identification. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 55, 216−227.
5.2.
2006
Kuusksalu, A., reintamm, T., Metsis, M., Kelve, M. (2006). Construction and screening of cDNA library from a marine sponge Chondrosia reniformis. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Buzios/Rio de Janeiro, Brazil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 157. (Serie Livros; 16).
3.4.
2004
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Rosa, S.; Kelve, M. (2004). Non-traditional enzymatic pathway of ATP utilization by the marine sponge Tedania sp. Proceedings of the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004: the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004. Sorrento, Italy, 65−65.
5.2.
2004
Kelve, M.; Lopp, A.; Reintamm, T.; Kuusksalu, A. (2004). Freshwater sponge cell cultures as model systems for biochemical pathways present in marine sponges. Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004. EAS (European Aquaculture Society) Special Publication, 34: Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004..
1.1.
2003
Kelve, M.; Kuusksalu, A.; Lopp, A.; Reintamm, T. (2003). Sponge (2',5')oligoadenylate synthetase activity in the whole sponge organism and in a primary cell culture. Journal of Biotechnology, 100, 177−180.
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Subbi, J.; Kelve, M. (2003). Qualitative and quantitative aspects of 2-5A synthesizing capacity of different marine sponges. Biomolecular Engineering, 20, 389−399.
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Pehk, T.; Kelve, M. (2003). ATP N-glycosidase – a novel ATP converting activity from marine sponge Axinella polypoides. European Journal of Biochemistry, 270, 4122−4132.
1.1.
2002
Grebenjuk, V.A.; Kuusksalu, A.; Kelve, M.; Schütze, J.; Schröder, H.C.; Müller, W.E. (2002). Induction of (2'-5')oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide. European Journal of Biochemistry, 269, 1382−1392.
1.1.
2002
Lopp, A.; Kuusksalu, A.; Reintamm, T.; Müller, W.E.; Kelve, M. (2002). 2',5'-oligoadenylate synthetase from a lower invertebrate, the marine sponge Geodia cydonium, does not need dsRNA for its enzymatic activity. Biochimica et Biophysica Acta, 1590, 140−149.
1.1.
2000
Lopp, A.; Kuusksalu, A.; Samuel, K.; Kelve, M. (2000). Expression and activity of 2-5A synthetase in the course of differentiation and apoptosis of PC12 cells. Cytokine, 12, 737−741.
1.1.
1999
Wiens, M.; Kuusksalu, A.; Kelve, M.; Müller, W.E.G. (1999). Origin of the interferon-inducible (2'-5')oligoadenylate synthetase in vertebrates : cloning of the (2'-5') oligoadenylate synthetase from the marine sponge Geodia cydonium. FEBS Letters, 462, 12−18.
1.3.
1999
Lopp, Annika; Kuusksalu, Anne; Samuel, Külli; Kelve, Merike (1999). 2-5A synthetase induction during PC12 cell death induced by serum starvation. Proceedings of the Estonian Academy of Sciences. Chemistry, 48, 109−118.
5.2.
1999
Nigul, Lenne;Aaspõllu, Anu;Aader, Ants;Kuusksalu, Anne;Truve, Erkki" (1999). 2-5A system - existence and applications in plants. EMBO workshop "Post-transcriptional regulation of gene expression in plants". Leysin, Switzerland.. cp1.
5.2.
1999
Sarmiento, Cecilia; Nigul, Lenne; Aader, Ants; Kuusksalu, Anne; Truve, Erkki (1999). Gene silencing in tobacco protoplasts. XIth International Congress of Virology. Abstract Book. Sydney, Australia. 163.
1.1.
1998
Kuusksalu, A.; Subbi, J.; Pehk, Tõnis; Reintamm, T.; Müller, W.E.G.; Kelve, Merike (1998). Identification of the reaction products of (2`-5`)-oligoadenylate synthetase in marine sponge. European Journal of Biochemistry, 257 (2), 420−426.
3.2.
1998
"Kelve, Merike;Kuusksalu, A." (1998). Modulation of (2`-5`)oligoadenylate synthetase by environmental stress in the marine sponge Geodia cydonium. (147−155).. TTY puuduv kirjastus.
5.2.
1998
Kuusksalu, A.; Subbi, J.; Pehk, Tõnis; Reintamm, T.; Kelve, Merike (1998). (2`-5`)-oligoadenylate system in marine sponges. 326−326.
1.1.
1997
Schröder, H.C.; Wiens, M.; Kuusksalu, A.; Kelve, M.; Mueller, W.E.G (1997). Modulation of 2´-5' oligoadenylate synthetase by environmental stress in the marine sponge Geodia cydonium. Environmental Toxicology and Chemistry, 16 (7), 1403−1409.
5.2.
1996
Truve, Erkki; Aaspõllu, Anu; Lopp, Annika; Kuusksalu, Anne; Tabler, Martin; Kelve, Merike (1996). Specific suppression of 2-5A system components by catalytic RNAs. The Uppsala BMC Summer program Workshop on Nucleic Acids: Chemistry, Structure and Biological Function. Sandhamn, 5-7 September.
1.1.
1995
Kuusksalu, A.; Pihlak, A.; Müller, W.E.; Kelve, M. (1995). The (2'-5')oligoadenylate synthetase is present in the lowest multicellular organisms, the marine sponges. Demonstration of the existence and identification of its reaction products. European Journal of Biochemistry, 232, 351−357.
1.1.
1995
Kuusksalu, A.; Truve, E.; Aaspõllu, A.; Kelve, M.; Scheffer, U.; Müller, W. E. G. (1995). Impairment of intracellular antiviral defence with age: age-dependent changes in expression of interferon-induced and double-stranded RNA-activated 2-5A synthetase in rat. Mechanisms of Ageing and Development, 78, 103−115.
1.1.
1994
Truve, E.; Kelve, M.; Aaspõllu, A.; Kuusksalu, A.; Seppänen, P.; Saarma, M. (1994). Principles and background for the construction of transgenic plants displaying multiple virus resistance. Archives of Virology, S9, 41−50.
1.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G.; Schröder, H. C. (1994). Rapid reduction of mRNA coding for 2'-5'-oligoadenylate synthetase in rat pheochromocytoma PC12 cells during apoptosis. Cellular and Molecular Biology, 40, 165−173.
3.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G. (1994). Reduction of 2’-5’-oligoadenylate synthetase mRNA level in rat pheochromocytoma PC12 cells during apoptosis. Müller, W. E. G.. Use of Aquatic Invertebrates as Tools for Monitoring of Environmental Hazards (97−108).. Gustav Fischer Verlag.
5.2.
1994
Schröder, H.C.; Kuusksalu, A.; Truve, E.; Aaspõllu, A.; Kelve, M.; Scheffer, U.; Dapper, J.; Müller, W.E.G. (1994). Intrazelluläre Immunität im Alter: Alternsabhängige Verringerung der Expression der 2-5A-Synthetase in Ratten. Deutsche Gesellschaft für Alternsforschung, 4. Tagung. Nürnberg, 11.-12. Nov.

Tööstusomand

12.11.2018

Anne Kuusksalu

https://www.etis.ee/CV/Anne_Kuusksalu/eng
26.07.1959
6204432
anne.kuusksalu@ttu.ee

Career

Institutions and positions
2005–31.12.2016   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Diagnostics, Senior Researcher (1,00)
01.01.2004–31.12.2007   
NICPB, senior research scientist
01.01.1986–31.12.2004   
National Institute of Chemical Physics and Biophysics (NICPB), laboratory of molecular genetics, research scientist
01.01.1982–31.12.1986   
Institute of Experimental Biology, laboratory of molecular biology, research scientist
 
 
Education
Tartu State University, department of physics and chemistry

Qualifications

Academic degrees
Anne Kuusksalu, Doctor's Degree, 2003, (sup) Merike Kelve, 2-5A süntetaas merekäsnas Geodia Cydonium (2-5A Synthetase from the Marine Sponge Geodia cydonium), Tallinn University of Technology Faculty of Science, Department of Gene Technology.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.1. Biochemistry; SPECIFICATION: Enzymes involved in animal molecular defence mechanisms, the diversity of their roles and gene regulation
 
 
Additional information
Ph.D.
Tallinn University of Technology, 2003

Completed projects

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2014
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Hansen Kjaer, Karina; Justesen, Just; Kelve, Merike (2014). Enzymatically active 2',5'-oligoadenylate synthetases are widely distributed among Metazoa, including protostome lineage. Biochimie, 97, 200−209.10.1016/j.biochi.2013.10.015.
1.1.
2012
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; de Rosa, Salvatore; Kelve, Merike (2012). A novel endoribonuclease from the marine sponge Tethya aurantium specific to 2',5'-phosphodiester bond. Biochimie, 94, 1635−1646.10.1016/j.biochi.2012.04.002.
1.1.
2011
Vallmann, Kerli; Aas, Nele; Reintamm, Tõnu; Lopp, Annika; Kuusksalu, Anne; Kelve, Merike (2011). Expressed 2-5A synthetase genes and pseudogenes in the marine sponge Geodia barretti. Gene, 478, 42−49.10.1016/j.gene.2011.01.014.
1.1.
2010
Lopp, Annika; Reintamm, Tõnu; Kuusksalu, Anne; Tammiste, Indrek; Pihlak, Arno; Kelve, Merike (2010). Natural Occurrence of 2′,5′-Linked Heteronucleotides in Marine Sponges. Marine Drugs, 8, 235−254.10.3390/md8020235.
5.1.
2009
Kuusksalu, A.; Lopp, A.; Päri, M.; Reintamm, T.; Kelve, M. (2009). Interferon-induced 2',5'-oligoadenylate synthetases versus those from sponges, evolutionarily lowest multicellyular animals. Cytokine, 48: Tri-Society Annual Conference 2009 of SLB, ICS and ISICR: Cellular and Cytokine Interactions in Health and Disease. Lisbon, Portugal. _EditorsAbbr Sir Gordon W. Duff; Scott K. Durum. Oxford, UK: Elsevier, 85−86. (1-2).10.1016/j.cyto.2009.07.308.
1.1.
2008
Reintamm, Tõnu; Kuusksalu, Anne; Metsis, Madis; Päri, Mailis; Vallmann, Kerli; Lopp, Annika; Justesen, Just; Kelve, Merike (2008). Sponge OAS has a distinct genomic structure within the 2-5A synthetase family. Molecular Genetics and Genomics, 280, 453−466.10.1007/s00438-008-0379-5.
1.1.
2007
Päri, Mailis; Kuusksalu, Anne; Lopp, Annika; Reintamm, Tõnu; Justesen, Just; Kelve, Merike (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge < EM >Geodia cydonium< /EM >. FEBS Journal, 274, 3462−3474.10.1111/j.1742-4658.2007.05878.x.
1.3.
2007
Kuusksalu, Anne; Metsis, Madis; Reintamm, Tõnu; Kelve, Merike (2007). Construction and characterization of a cDNA library from the marine sponge Chondrosia reniformis. In: Custodio, M.R.; Lobo-Hajdu, G.; Hajdu, E.; Muricy, G (_EditorsAbbr). Porifera Research - Biodiversity, Innovation and Sustainability (405−412).. Rio de Janeiro: Museu Nacional. (Serie Livros).
5.1.
2007
Lopp, A.; Päri, M.; Kuusksalu, A.; Reintamm, T.; Justesen, J.; Kelve, M. (2007). Expression and characterization of recombinant 2',5'-oligoadenylate synthetase from the marine sponge< EM > Geodia cydonium< /EM >. Journal of Interferon & Cytokine Reseach, 27: International Society for Interferon and Cytokine Research, Interferon Anniversary Meeting (50th Anniversary of the Discovery of Interferon), Sept. 16-19, 2007, Oxford, England. Mary Ann Liebert Inc, 719.
1.3.
2006
Roovere, T.; Lopp, A.; Reintamm, T.; Kuusksalu, A.; Richelle-Maurer, E.; Kelve, M. (2006). Freshwater sponges in Estonia: genetic and morphological identification. Proceedings of the Estonian Academy of Sciences. Biology. Ecology, 55, 216−227.
5.2.
2006
Kuusksalu, A., reintamm, T., Metsis, M., Kelve, M. (2006). Construction and screening of cDNA library from a marine sponge Chondrosia reniformis. 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Book of Abstracts: 7th International Sponge Symposium. Biodiversity, Innovation, Sustainability. Buzios/Rio de Janeiro, Brazil. May 07-13, 2006. _EditorsAbbr Custodio, M.R., Lobo-Hajdu, G., Hajdu, E., Muricy, G. Rio de Janeiro: Museu Nacional, 157. (Serie Livros; 16).
3.4.
2004
Lopp, A.; Reintamm, T.; Kuusksalu, A.; Rosa, S.; Kelve, M. (2004). Non-traditional enzymatic pathway of ATP utilization by the marine sponge Tedania sp. Proceedings of the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004: the XI International Symposium on Marine Natural Products, Sorrento, Italy, Sept. 4th-9th, 2004. Sorrento, Italy, 65−65.
5.2.
2004
Kelve, M.; Lopp, A.; Reintamm, T.; Kuusksalu, A. (2004). Freshwater sponge cell cultures as model systems for biochemical pathways present in marine sponges. Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004. EAS (European Aquaculture Society) Special Publication, 34: Aquaculture Europe 2004 Conference “Biotechnologies for quality”, Barcelona, Spain, Oct. 20-23, 2004..
1.1.
2003
Kelve, M.; Kuusksalu, A.; Lopp, A.; Reintamm, T. (2003). Sponge (2',5')oligoadenylate synthetase activity in the whole sponge organism and in a primary cell culture. Journal of Biotechnology, 100, 177−180.
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Subbi, J.; Kelve, M. (2003). Qualitative and quantitative aspects of 2-5A synthesizing capacity of different marine sponges. Biomolecular Engineering, 20, 389−399.
1.1.
2003
Reintamm, T.; Lopp, A.; Kuusksalu, A.; Pehk, T.; Kelve, M. (2003). ATP N-glycosidase – a novel ATP converting activity from marine sponge Axinella polypoides. European Journal of Biochemistry, 270, 4122−4132.
1.1.
2002
Grebenjuk, V.A.; Kuusksalu, A.; Kelve, M.; Schütze, J.; Schröder, H.C.; Müller, W.E. (2002). Induction of (2'-5')oligoadenylate synthetase in the marine sponges Suberites domuncula and Geodia cydonium by the bacterial endotoxin lipopolysaccharide. European Journal of Biochemistry, 269, 1382−1392.
1.1.
2002
Lopp, A.; Kuusksalu, A.; Reintamm, T.; Müller, W.E.; Kelve, M. (2002). 2',5'-oligoadenylate synthetase from a lower invertebrate, the marine sponge Geodia cydonium, does not need dsRNA for its enzymatic activity. Biochimica et Biophysica Acta, 1590, 140−149.
1.1.
2000
Lopp, A.; Kuusksalu, A.; Samuel, K.; Kelve, M. (2000). Expression and activity of 2-5A synthetase in the course of differentiation and apoptosis of PC12 cells. Cytokine, 12, 737−741.
1.1.
1999
Wiens, M.; Kuusksalu, A.; Kelve, M.; Müller, W.E.G. (1999). Origin of the interferon-inducible (2'-5')oligoadenylate synthetase in vertebrates : cloning of the (2'-5') oligoadenylate synthetase from the marine sponge Geodia cydonium. FEBS Letters, 462, 12−18.
1.3.
1999
Lopp, Annika; Kuusksalu, Anne; Samuel, Külli; Kelve, Merike (1999). 2-5A synthetase induction during PC12 cell death induced by serum starvation. Proceedings of the Estonian Academy of Sciences. Chemistry, 48, 109−118.
5.2.
1999
Nigul, Lenne;Aaspõllu, Anu;Aader, Ants;Kuusksalu, Anne;Truve, Erkki" (1999). 2-5A system - existence and applications in plants. EMBO workshop "Post-transcriptional regulation of gene expression in plants". Leysin, Switzerland.. cp1.
5.2.
1999
Sarmiento, Cecilia; Nigul, Lenne; Aader, Ants; Kuusksalu, Anne; Truve, Erkki (1999). Gene silencing in tobacco protoplasts. XIth International Congress of Virology. Abstract Book. Sydney, Australia. 163.
1.1.
1998
Kuusksalu, A.; Subbi, J.; Pehk, Tõnis; Reintamm, T.; Müller, W.E.G.; Kelve, Merike (1998). Identification of the reaction products of (2`-5`)-oligoadenylate synthetase in marine sponge. European Journal of Biochemistry, 257 (2), 420−426.
3.2.
1998
"Kelve, Merike;Kuusksalu, A." (1998). Modulation of (2`-5`)oligoadenylate synthetase by environmental stress in the marine sponge Geodia cydonium. (147−155).. TTY puuduv kirjastus.
5.2.
1998
Kuusksalu, A.; Subbi, J.; Pehk, Tõnis; Reintamm, T.; Kelve, Merike (1998). (2`-5`)-oligoadenylate system in marine sponges. 326−326.
1.1.
1997
Schröder, H.C.; Wiens, M.; Kuusksalu, A.; Kelve, M.; Mueller, W.E.G (1997). Modulation of 2´-5' oligoadenylate synthetase by environmental stress in the marine sponge Geodia cydonium. Environmental Toxicology and Chemistry, 16 (7), 1403−1409.
5.2.
1996
Truve, Erkki; Aaspõllu, Anu; Lopp, Annika; Kuusksalu, Anne; Tabler, Martin; Kelve, Merike (1996). Specific suppression of 2-5A system components by catalytic RNAs. The Uppsala BMC Summer program Workshop on Nucleic Acids: Chemistry, Structure and Biological Function. Sandhamn, 5-7 September.
1.1.
1995
Kuusksalu, A.; Pihlak, A.; Müller, W.E.; Kelve, M. (1995). The (2'-5')oligoadenylate synthetase is present in the lowest multicellular organisms, the marine sponges. Demonstration of the existence and identification of its reaction products. European Journal of Biochemistry, 232, 351−357.
1.1.
1995
Kuusksalu, A.; Truve, E.; Aaspõllu, A.; Kelve, M.; Scheffer, U.; Müller, W. E. G. (1995). Impairment of intracellular antiviral defence with age: age-dependent changes in expression of interferon-induced and double-stranded RNA-activated 2-5A synthetase in rat. Mechanisms of Ageing and Development, 78, 103−115.
1.1.
1994
Truve, E.; Kelve, M.; Aaspõllu, A.; Kuusksalu, A.; Seppänen, P.; Saarma, M. (1994). Principles and background for the construction of transgenic plants displaying multiple virus resistance. Archives of Virology, S9, 41−50.
1.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G.; Schröder, H. C. (1994). Rapid reduction of mRNA coding for 2'-5'-oligoadenylate synthetase in rat pheochromocytoma PC12 cells during apoptosis. Cellular and Molecular Biology, 40, 165−173.
3.1.
1994
Kelve, M.; Truve, E.; Aaspõllu, A.; Kuusksalu, A.; Dapper, J.; Perovic, S.; Müller, W. E. G. (1994). Reduction of 2’-5’-oligoadenylate synthetase mRNA level in rat pheochromocytoma PC12 cells during apoptosis. Müller, W. E. G.. Use of Aquatic Invertebrates as Tools for Monitoring of Environmental Hazards (97−108).. Gustav Fischer Verlag.
5.2.
1994
Schröder, H.C.; Kuusksalu, A.; Truve, E.; Aaspõllu, A.; Kelve, M.; Scheffer, U.; Dapper, J.; Müller, W.E.G. (1994). Intrazelluläre Immunität im Alter: Alternsabhängige Verringerung der Expression der 2-5A-Synthetase in Ratten. Deutsche Gesellschaft für Alternsforschung, 4. Tagung. Nürnberg, 11.-12. Nov.

Industrial property

12.11.2018
Detailne otsing
  • Leitud 6 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF5932Adenosiiniderivaatide ebatraditsioonilised signaalrajad alamates loomades01.01.200431.12.2007Merike KelveKeemilise ja Bioloogilise Füüsika Instituut51 970,40 EUR
MUUVFP599BluePharmTrain01.09.201331.08.2017Merike KelveTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool197 029,36 EUR
SFSF0222603s03Funktsionaalne proteoomika - struktuuri-aktiivsuse seosed ning molekulaarne äratundmine looduslikes valgukooslustes01.01.200331.12.2007Jüri SiigurKeemilise ja Bioloogilise Füüsika Instituut643 270,75 EUR
ETFETF9185Käsna ja mikroobi sümbioosi funktsionaalsed aspektid puriinide põhiainevahetuse näitel 01.01.201231.12.2015Merike KelveTallinna Tehnikaülikool, Matemaatika-loodusteaduskond69 600,00 EUR
SFSF0140108s08Nukleotiidide metabolismis osalevad ensüümid - võrdlev biokeemia, molekulaarbioloogia ja evolutsioonilised aspektid 01.01.200831.12.2013Merike KelveTallinna Tehnikaülikool, Matemaatika-loodusteaduskond302 690,08 EUR
ETFETF7421Nukleotiidide metabolismis osalevate ensüümide genoomse struktuuri ja aktiivsuse iseloomustamine madalaimates hulkraksetes loomades - käsnades 01.01.200831.12.2011Merike KelveTallinna Tehnikaülikool, Matemaatika-loodusteaduskond86 296,05 EUR