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Olen nõus

Urmas Arumäe

https://www.etis.ee/CV/Urmas_Arumäe/est
17.01.1957
6204437
(372)56939121
urmas.arumae@ttu.ee
E-8290-2016

Teenistuskäik

Töökohad ja ametid
01.11.2020–...   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut, vanemlektor (1,00)
01.01.2017–31.10.2020   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut, Dotsent (1,00)
01.01.2017–06.09.2020   
Tallinna Tehnikaülikool, Loodusteaduskond, Loodusteaduskonna dekanaat, teadus- ja arendusprodekaan (1,00)
01.08.2015–31.12.2016   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaarbioloogia õppetool, Dotsent (0,75)
2012–2015   
Tallinna Tehnikaülikool, Vanemteadur (0,75)
01.01.2012–31.12.2015   
Biotehnoloogia Instituut, Helsingi Ülikool, Biotehnoloogia Instituut, Helsingi Ülikool; vanemteadur (0.25) (0,25)
01.01.2011–31.12.2012   
Biotehnoloogia Instituut, Helsingi Ülikool; vanemteadur (1.00)
01.01.2006–31.12.2011   
Soome Akadeemia vanemteadur (1.00)
01.01.1990–31.12.2006   
Biotehnoloogia Instituut, Helsingi Ülikool; vanemteadur (1.00)
01.09.1983–28.02.1990   
Keemilise ja Bioloogilise Füüsika Instituut, Teadur (1,00)
01.09.1980–31.08.1983   
Keemilise ja Bioloogilise Füüsika Instituut, Nooremteadur (1,00)
 
 
Haridustee
1975–1980   
Tartu Ülikool
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2017−...   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia- ja biotehnoloogia instituut, teadus- ja arendusprodekaan

Kvalifikatsioon

Teaduskraadid
Urmas Arumäe, doktorikraad, 1987, (juh) Mart Saarma, Characterisation of monoclonal antibodies to nerve growth factors (Närvikasvu faktori vastaste monoklonaalsete antikehade iseloomustamine), Tartu Ülikool.
 
 

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2018
Božok, V.; Palgi, J.; Yu, L.; Arumäe, U. (2018). Antioxidative CXXC Peptide Motif From Mesencephalic Astrocyte-Derived Neurotrophic Factor Antagonizes Programmed Cell Death. Frontiers in Cell and Developmental Biology.10.3389/fcell.2018.00106.
1.1.
2018
Mätlik, K.; Anttila, J. E.; Kuan-Yin, T.; Smolander, O.-P.; Pakarinen, E.; Lehtonen, L.; Abo-Ramadan, U.; Lindholm, P.; Zheng, C.; Harvey, B.; Arumäe, U.; Lindahl, M.; Airavaara, M. (2018). Poststroke delivery of MANF promotes functional recovery in rats. Science Advances, 4 (5), #eaap8957.10.1126/sciadv.aap8957.
1.1.
2017
Mätlik, K.; Vihinen, H.; Bienemann, A.; Palgi, J.; Voutilainen, M.H.; Booms, S.; Lindahl, M.; Jokitalo, E.; Saarma, M., Huttunen, H.J.; Airavaara, M.; Arumäe, U. (2017). Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra. eNeuro, 4 (1), -.10.1523/ENEURO.0128-16.2017.
1.1.
2016
Raba, M.; Palgi, J.; Lehtivaara, M.; Arumäe, U. (2016). Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons. Frontiers in Cellular Neuroscience, 10 (66), 1−13.10.3389/fncel.2016.00066.
1.1.
2016
Pham DD, Do HT, Bruelle C, Kukkonen JP, Eriksson O, Mogollón I, Korhonen LT, Arumäe U, Lindholm D (2016). p75 neurotrophin receptor signaling activates sterol regulatory element-binding protein-2 in hepatocyte cells via p38 mitogen-activated protein kinase and caspase-3. Journal of Biological Chemistry, 291 (20), 10747−10758.10.1074/jbc.M116.722272.
1.1.
2015
Mätlik, K.; Yu, Li-Ying; Eesmaa, A.; Hellman, M.; Lindholm, P.; Peränen, J.; Galli, E.; Anttila, J.; Saarma, M.; Permi, P.; Airavaara, M.; Arumäe, U. (2015). Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity. Cell Death and Disease, 6, e2032−e2032.10.1038/cddis.2015.371.
1.1.
2015
Voutilainen, M. H; Arumäe, U.; Airavaara, M.; Saarma, M. (2015). Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease. FEBS Letters, 589 (24 Pt A), 3739−3748.10.1016/j.febslet.2015.09.031.
1.1.
2014
Mätlik, K; Abo-Ramadan, U; Harvey, BK; Arumäe, U; Airavaara, M.J (2014). AAV-mediated targeting of gene expression to the peri-infarct region in rat cortical stroke model. Journal of Neuroscience Methods, 236, 107−113.10.1016/j.jneumeth.2014.08.014.
1.1.
2013
Lindström, R.; Lindholm, P.; Kallijärvi, J.; Yu, L.Y.; Piepponen, T.P; Arumäe, U.; Saarma, M.; Heino, T.I. (2013). Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model. PLoS ONE, 8 (1), e73928. DOI: 10.1371/journal.pone.0054379.
1.1.
2013
Ichim, G; Genevois, AL; Menard, M; Yu, LY; Coelho-Aguiar, JM; Llambi, F; Jarrosson-Wuilleme, L; Lefebvre, J; Tulasne, D; Dupin, E; Le Douarin, N; Arumäe, U; Tauszig-Delamasure, S; Mehlen, P. (2013). The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment. Molecular Cell, 51 (5), 632−646.10.1016/j.molcel.2013.08.021.
1.1.
2013
Jakobson, M.; Jakobson, M.; Llano, O.; Palgi, J.; Arumäe, U. (2013). Multiple mechanisms repress N-Bak mRNA translation in the healthy and apoptotic neurons. Cell Death and Disease, 4, ARTN e777. DOI: 10.1038/cddis.2013.297.
1.1.
2013
Heermann, S.; Mätlik, K.; Hinz, U.; Fey, J.; Arumäe, U.; Krieglstein, K. (2013). GDNF mediates survival of murine sympathetic precursors. Journal of Neuroscience Research, 91 (6), 780−785.10.1002/jnr.23188.
1.1.
2012
Jakobson M, Lintulahti A, Arumäe U. (2012). mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in the neurons. Cell Death and Disease, 3:e269.
1.1.
2012
Kysenius K, Muggalla P, Mätlik K, Arumäe U, Huttunen H. (2012). PCSK9 regulates neuronal apoptosis by adjusting apoer2 levels and signaling. Cellular and Molecular Life Sciences, 69, 1903−1916.
1.1.
2012
Shulga, A; Magalhaes, A; Autio, H; Plantman, S; Di Lieto, A; Nykjaer, A; Carlstedt, T; Risling, M; Arumäe, U; Castren, E; Rivera, C. (2012). The loop diuretic bumetanide blocks post-traumatic p75NTR upregulation and rescues injured neurons. Journal of Neuroscience, 32, 1757−1770.
1.1.
2011
Autio H, Mätlik K, Rantamäki T, Lindemann L, Hoener MC, Chao M, Arumäe U, Castrén, E. (2011). Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology, 61, 1291−1296.
1.1.
2011
Hellman, M.; Arumäe, U.; Yu, L.Y.; Lindholm, P.; Peränen, J.; Saarma, M.; Permi, P. (2011). Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons. Journal of Biological Chemistry, 286 (4), 2675−2680.
1.1.
2010
Sidorova, Y A; Mätlik, K; Paveliev, M; Lindahl, M; Piranen, E; Milbrandt, J; Arumäe, U; Saarma, M; Bespalov, M M (2010). Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease. Molecular and Cellular Neuroscience, 44 (3), 223−232.
1.1.
2008
Yu, L.Y.; Saarma, M.; Arumäe, U. (2008). Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons. Journal of Neuroscience, 28 (30), 7467−7475.
1.1.
2008
Yu, L.Y.; Arumäe, U. (2008). Survival assay of transiently transfected dopaminergic neurons. Journal of Neuroscience Methods, 169 (1), 8−15.
1.1.
2007
Tauszig-Delamasure, S.; Yu, L. Y.; Cabrera, J. R.; Bouzas-Rodriguez, J.; Mermet-Bouvier, C.; Guix, C.; Bordeaux, M. C.; Arumäe, U.; Mehlen, P. (2007). The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proceedings of the National Academy of Sciences of the United States of America, 13361−13366.
1.1.
2007
Aalto, A.; Sarin, L. P.; van Dijk, A. A.; Saarma, M.; Poranen, M. M.; Arumäe, U.; Bamford, D. H. (2007). Large Scale Production of dsRNA and siRNA Pools for RNA Interference Utilizing Bacteriophage phi6 RNA-dependent RNA Polymerase. RNA, 13 (3), 422−429.
1.1.
2007
Paveliev, M.; Lume, M.; Velthut, A.; Phillips, M.; Arumäe, U.; Saarma, M. (2007). Neurotrophic factors switch between two signaling pathways that trigger axonal growth. Journal of Cell Science, 120, 2507−2516. DOI: 10.1242/jcs.003590.
1.1.
2004
Lindholm, D.; Arumäe, U. (2004). Cell differentiation: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins. Journal of Cell Biology, 167 (2), 193−195.
1.1.
2003
Yu, L.-Y.; Korhonen, L.; Martinez, R.; Jokitalo, E.; Chen, Y.; Arumäe, U.; Lindholm, D. (2003). Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells. Molecular and Cellular Neuroscience, 22 (3), 303−318.
1.1.
2003
Yu, Li-Ying; Jokitalo, E.; Sun, Yun-Fu; Mehlen, P.; Lindholm, D.; Saarma, Mart; Arumäe, Urmas (2003). GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway. Journal of Cell Biology, 163 (5), 987−997.
1.1.
2003
Sun, Yun-Fu; Yu, Li-Ying; Saarma, Mart; Arumäe, Urmas (2003). Mutational analysis of N-Bak reveals different structural requirements for antiapoptotic activity in neurons and proapoptotic activity in nonneuronal cells. Molecular and Cellular Neuroscience, 23 (1), 134−143.
1.1.
2002
Lindholm, D.; Mercer, E.A.; Yu, L-Y.; Chen, Y.; Kukkonen, J.; Korhonen, L.; Arumäe, U. (2002). Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF dependent sympathetic neurons. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 138−147. DOI: 10.1016/S1570-9639(02)00454-5.
1.1.
2001
Sun, Y.-F; Yu, L.-Y.; Saarma, M.; Timmusk, T.; Arumäe, U. (2001). Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells. Journal of Biological Chemistry, 276 (19), 16240−16247.
1.1.
2001
Lindahl, M.; Poteryaev, D.; Yu, L.; Arumäe, U.; Timmusk, T.; Bongarzone, I.; Aiello, A.; Pierotti, M. A.; Airaksinen, M. S.; Saarma, M. (2001). Human GFRα4 is the receptor for persephin, and is predominantly expressed in normal and malignant thyroid medullary cells. Journal of Biological Chemistry, 276 (12), 9344−9351.
1.1.
2001
Hamner, S.; Arumäe, Urmas; Li-Ying, Y.; Sun, Y.-F.; Saarma, Mart; Lindholm, D. (2001). Functional characterization of two splice variants of rat Bad and their interaction with Bcl-w in sympathetic neurons. Molecular and cellular neurosciences, 17 (1), 97−106.
1.1.
2000
Schober, A.; Arumäe, U.; Saarma, Mart; Unsicker, K. (2000). Expression of GFRa-1, GFRA-2, and c-Ret mRNAs in rat adrenal gland. Journal of neurocytology, 29 (3), 209−213.
1.1.
2000
Laurikainen, A.; Hiltunen, J.O.; Thomas-Crusells, J.; Vanhatalo, S.; Arumäe, U.; Airaksinen, M.S.; Klinge, E.; Saarma, Mart (2000). Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat. Journal of Neurobiology, 43 (2), 198−205.
1.1.
1999
Schober, A.; Hertel, R.; Arumäe, U.; Farkas, L.; Jaszai, J.; Krieglstein, K.; Saarma, M.; Unsicker, K. (1999). GDNF rescues target-deprived sympathetic spinal cord neurons but requires TGF-β as co-factor in vivo. Journal of Neuroscience, 19 (6), 2008−2015.
1.1.
1999
Rossi, J.; Luukko, K.; Poteriaev, D.; Sun, Y.F.; Laakso, T.; Eerikäinen, S.; Tuominen, R.; Lakso, M.; Rauvala, H.; Arumäe, U.; Pasternack, M.; Saarma, M.; Airaksinen, M.S. (1999). Retarded growth and deficits in the parasympathetic nervous system in mice lacking GFRα2, a functional neurturin receptor. Neuron, 22 (2), 243−252.
1.1.
1999
Poteriaev, D.; Titievsky, A.D.; Sun, Y.F.; Thomas-Crusells, J.; Lindahl, M.; Billaud, M.; Arumäe, U.; Saarma, Mart (1999). GDNF triggers a novel Ret-independent Src-kinase family-coupled signaling via a GPI-linked GDNF receptor a[alfa]1. FEBS Letters, 463, 63−66.
1.1.
1999
Haapasalo, A.; Saarelainen, T.; Moshnyakov, M.; Arumäe, U.; Kiema, T.-R.; Saarma, Mart; Wong, G.; Castren, E. (1999). Expression of the naturally occuring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. Oncogene, 18 (6), 1285−1296.
1.1.
1997
Luukko, K.; Arumäe, U.; Karavanov, A.; Moshnyakov, M.; Sainio, K.; Sariola, H.; Saarma, M.; Thesleff, I. (1997). Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis. Developmental Dynamics, 210 (2), 117−129.
1.1.
1997
Suvanto, P.; Wartiovaara, K.; Lindahl, M.; Arumäe, U.; Moshnyakov, M.; Horellikuitunen, N.; Airaksinen, M. S.; Palotie, A.; Sariola, H.; Saarma, M. (1997). Cloning, mRNA distribution and chromosomal localization of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. Human Molecular Genetics, 6 (8), 1267−1273.
1.1.
1997
Sainio, K.; Suvanto, P.; Davies, J.; Wartiovaara, J.; Wartiovaara, K.; Saarma, M.; Arumäe, U.; Meng, X.; Lindahl, M.; Pachnis, V.; Sariola, H. (1997). Glial cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development, 124 (20), 4077−4087.
1.1.
1996
Trupp, M.; Arenas, E.; Fainzilber, M.; Nilsson, A.-S.; Sieber, B.-A.; Grigoriou, M.; Kilkenny, C.; Salazar-Crueso, E.; Pachnis, V.; Arumäe, U.; Sariola, H.; Saarma, M.; Ibáñez, C. F. (1996). Functional recptor for GDNF encoded by the c-ret proto-oncogene. Nature, 381 (6585), 785−789.
1.1.
1996
Moshnyakov, M.; Arumäe, U.; Saarma, M. (1996). mRNAs for one, two or three members of trk receptor family are expressed in single rat trigeminal ganglion neurons. Molecular Brain Research, 43, 141−148.
1.1.
1996
Hiltunen, J. O.; Arumäe, U.; Moshnyakov, M.; Saarma, M. (1996). Expression of mRNAs for neurotrophins and their receptors in developing rat heart. Circulation Research, 79 (5), 930−939.
1.1.
1996
Suvanto, P.; Hiltunen, J. O.; Arumäe, U.; Moshnyakov, M.; Sariola, H.; Sainio, K.; Saarma, M. (1996). Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization. European Journal of Neuroscience, 8 (4), 816−822.
1.1.
1996
Simonen, M.; Vihinen, H.; Jämsä, E.; Arumäe, U.; Kalkkinen, N.; Makarow, M. (1996). The hsp150Δ-carrier confers secretion competence to the rat nerve growth factor receptor ectodomain in Saccharomyces cerevisiae. Yeast, 12 (5), 457−466.
1.1.
1994
Pirvola, U.; Arumäe, U.; Moshnyakov, M.; Palgi, J.; Saarma, M.; Ylikoski, J. (1994). Coordinated expression and function of neurotrophic factors and their receptors in the rat inner ear during target innervation. Hearing research, 75, 131−144.
1.1.
1993
Arumäe, U.; Pirvola, U.; Palgi, J.; Kiema, T.-R.; Palm, K.; Moshnyakov, M.; Ylikoski, J.; Saarma, M. (1993). Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth. Journal of Cell Biology, 122 (5), 1053−1065.
1.1.
1993
Ylikoski, J.; Pirvola, U.; Moshnyakov, M.; Palgi, J.; Arumäe, U.; Saarma, M. (1993). Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear. Hearing research, 65, 69−78.
1.1.
1992
Pirvola, U.; Palgi, J.; Ylikoski, J.; Lehtonen, E.; Arumäe, U.; Saarma, M. (1992). Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in the peripheral target fields of developing inner ear ganglia. Proceedings of the National Academy of Sciences of the United States of America, 89 (20), 9915−9919.
1.1.
1991
Sariola, H.; Saarma, M.; Sainio, K.; Arumäe, U.; Palgi, J.; Vaahtokari, A.; Thesleff, I.; Karavanov, A. (1991). Dependence of kidney morphogenesis on the expression of nerve growth factor receptor. Science, 254 (5031), 571−573.
1.1.
1991
Joachimiak, A.; Giel, M.; Otwinowski, Z.; Arumäe, U.; Siigur, J.; Saarma, M.; Sigler, P. B.; Barciszewski, J. (1991). Crystallization and preliminary X-ray analysis of nerve growth factor from Vipera lebetina. Journal of Crystal Growth, 214−219.
1.1.
1989
Arumäe, U.; Neuman, T.; Sinijärv, R.; Saarma, M. (1989). Sensitive time-resolved fluoroimmunoassay of the nerve growth factor and the disappearance of the nerve growth factor from rat pheochromocytoma PC12 cell culture medium. Journal of Immunological Methods, 122 (1), 59−65.
1.1.
1987
Glinsky, G. V., Ivanova, A. B., Vinnitsky, P. V., Arumäe, U., Siigur, J., Neuman T. (1987). NGF may be the metastase growth factor. Annals of New York Academy of Sciences, 656−659.
1.1.
1987
Arumäe, Urmas; Siigur, Jüri; Neuman, Toomas; Saarma, Mart. (1987). Monoclonal antibodies against Vipera lebetina venom nerve growth factor cross-react with other snake venom nerve growth factors. Molecular Immunology, 24 (12), 1295−1302.
1.1.
1987
Siigur, Jüri; Arumäe, Urmas; Neuman, Toomas; Siigur, Ene; Saarma, Mart (1987). Monoclonal antibody immunoaffinity chromatography of the nerve growth factor from snake venoms. Comparative Biochemistry and Physiology, 87B (2), 329−384.
1.1.
1986
Siigur, J.; Arumäe, U.; Neuman, T.; Samel, M.; Siigur, E.; Saarma, M. (1986). Isolation and characterization of nerve growth factor from Vipera berus berus (common viper) venom. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 83 (3), 621−625.

Tööstusomand

29.10.2020

Urmas Arumäe

https://www.etis.ee/CV/Urmas_Arumäe/eng
17.01.1957
6204437
(372)56939121
urmas.arumae@ttu.ee
E-8290-2016

Career

Institutions and positions
01.11.2020–...   
Tallinn University of Technology , School of Science, Department of Chemistry and Biotechnology, Senior Lecturer (1,00)
01.01.2017–31.10.2020   
Tallinn University of Technology , School of Science, Department of Chemistry and Biotechnology, Associate Professor (1,00)
01.01.2017–06.09.2020   
Tallinn University of Technology , School of Science, Loodusteaduskonna dekanaat, Vice-Dean for Research and Development (1,00)
01.08.2015–31.12.2016   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Biology, Associate Professor (0,75)
2012–2015   
Tallinn University of Technology , Senior Researcher (0,75)
01.01.2012–31.12.2015   
Institute of Biotechnology, University of Helsinki, Institute of Biotechnology, University of Helsinki; Senior research scientist (0,25) (0,25)
01.01.2011–31.12.2012   
Institute of Biotechnology, University of Helsinki; Senior research scientist (1.00)
01.01.2006–31.12.2011   
Research Fellow of the Academy of Finland (1.00)
01.01.1990–31.12.2006   
Institute of Biotechnology, University of Helsinki; Senior research scientist (1.00)
01.09.1983–28.02.1990   
National Institute of Chemical Physics and Biophysics, Research scientist (1,00)
01.09.1980–31.08.1983   
National Institute of Chemical Physics and Biophysics, Junior research scientist (1,00)
 
 
Education
1975–1980   
University of Tartu
 
 
R&D related managerial and administrative work
2017−...   
Tallinna Tehnikaülikool, Loodusteaduskond, Keemia- ja biotehnoloogia instituut, teadus- ja arendusprodekaan

Qualifications

Academic degrees
Urmas Arumäe, Doctor's Degree, 1987, (sup) Mart Saarma, Characterisation of monoclonal antibodies to nerve growth factors, University of Tartu.
 
 

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2018
Božok, V.; Palgi, J.; Yu, L.; Arumäe, U. (2018). Antioxidative CXXC Peptide Motif From Mesencephalic Astrocyte-Derived Neurotrophic Factor Antagonizes Programmed Cell Death. Frontiers in Cell and Developmental Biology.10.3389/fcell.2018.00106.
1.1.
2018
Mätlik, K.; Anttila, J. E.; Kuan-Yin, T.; Smolander, O.-P.; Pakarinen, E.; Lehtonen, L.; Abo-Ramadan, U.; Lindholm, P.; Zheng, C.; Harvey, B.; Arumäe, U.; Lindahl, M.; Airavaara, M. (2018). Poststroke delivery of MANF promotes functional recovery in rats. Science Advances, 4 (5), #eaap8957.10.1126/sciadv.aap8957.
1.1.
2017
Mätlik, K.; Vihinen, H.; Bienemann, A.; Palgi, J.; Voutilainen, M.H.; Booms, S.; Lindahl, M.; Jokitalo, E.; Saarma, M., Huttunen, H.J.; Airavaara, M.; Arumäe, U. (2017). Intrastriatally Infused Exogenous CDNF Is Endocytosed and Retrogradely Transported to Substantia Nigra. eNeuro, 4 (1), -.10.1523/ENEURO.0128-16.2017.
1.1.
2016
Raba, M.; Palgi, J.; Lehtivaara, M.; Arumäe, U. (2016). Microarray Analysis Reveals Increased Transcriptional Repression and Reduced Metabolic Activity but Not Major Changes in the Core Apoptotic Machinery during Maturation of Sympathetic Neurons. Frontiers in Cellular Neuroscience, 10 (66), 1−13.10.3389/fncel.2016.00066.
1.1.
2016
Pham DD, Do HT, Bruelle C, Kukkonen JP, Eriksson O, Mogollón I, Korhonen LT, Arumäe U, Lindholm D (2016). p75 neurotrophin receptor signaling activates sterol regulatory element-binding protein-2 in hepatocyte cells via p38 mitogen-activated protein kinase and caspase-3. Journal of Biological Chemistry, 291 (20), 10747−10758.10.1074/jbc.M116.722272.
1.1.
2015
Mätlik, K.; Yu, Li-Ying; Eesmaa, A.; Hellman, M.; Lindholm, P.; Peränen, J.; Galli, E.; Anttila, J.; Saarma, M.; Permi, P.; Airavaara, M.; Arumäe, U. (2015). Role of two sequence motifs of mesencephalic astrocyte-derived neurotrophic factor in its survival-promoting activity. Cell Death and Disease, 6, e2032−e2032.10.1038/cddis.2015.371.
1.1.
2015
Voutilainen, M. H; Arumäe, U.; Airavaara, M.; Saarma, M. (2015). Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease. FEBS Letters, 589 (24 Pt A), 3739−3748.10.1016/j.febslet.2015.09.031.
1.1.
2014
Mätlik, K; Abo-Ramadan, U; Harvey, BK; Arumäe, U; Airavaara, M.J (2014). AAV-mediated targeting of gene expression to the peri-infarct region in rat cortical stroke model. Journal of Neuroscience Methods, 236, 107−113.10.1016/j.jneumeth.2014.08.014.
1.1.
2013
Lindström, R.; Lindholm, P.; Kallijärvi, J.; Yu, L.Y.; Piepponen, T.P; Arumäe, U.; Saarma, M.; Heino, T.I. (2013). Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model. PLoS ONE, 8 (1), e73928. DOI: 10.1371/journal.pone.0054379.
1.1.
2013
Ichim, G; Genevois, AL; Menard, M; Yu, LY; Coelho-Aguiar, JM; Llambi, F; Jarrosson-Wuilleme, L; Lefebvre, J; Tulasne, D; Dupin, E; Le Douarin, N; Arumäe, U; Tauszig-Delamasure, S; Mehlen, P. (2013). The dependence receptor TrkC triggers mitochondria-dependent apoptosis upon Cobra-1 recruitment. Molecular Cell, 51 (5), 632−646.10.1016/j.molcel.2013.08.021.
1.1.
2013
Jakobson, M.; Jakobson, M.; Llano, O.; Palgi, J.; Arumäe, U. (2013). Multiple mechanisms repress N-Bak mRNA translation in the healthy and apoptotic neurons. Cell Death and Disease, 4, ARTN e777. DOI: 10.1038/cddis.2013.297.
1.1.
2013
Heermann, S.; Mätlik, K.; Hinz, U.; Fey, J.; Arumäe, U.; Krieglstein, K. (2013). GDNF mediates survival of murine sympathetic precursors. Journal of Neuroscience Research, 91 (6), 780−785.10.1002/jnr.23188.
1.1.
2012
Jakobson M, Lintulahti A, Arumäe U. (2012). mRNA for N-Bak, a neuron-specific BH3-only splice isoform of Bak, escapes nonsense-mediated decay and is translationally repressed in the neurons. Cell Death and Disease, 3:e269.
1.1.
2012
Kysenius K, Muggalla P, Mätlik K, Arumäe U, Huttunen H. (2012). PCSK9 regulates neuronal apoptosis by adjusting apoer2 levels and signaling. Cellular and Molecular Life Sciences, 69, 1903−1916.
1.1.
2012
Shulga, A; Magalhaes, A; Autio, H; Plantman, S; Di Lieto, A; Nykjaer, A; Carlstedt, T; Risling, M; Arumäe, U; Castren, E; Rivera, C. (2012). The loop diuretic bumetanide blocks post-traumatic p75NTR upregulation and rescues injured neurons. Journal of Neuroscience, 32, 1757−1770.
1.1.
2011
Autio H, Mätlik K, Rantamäki T, Lindemann L, Hoener MC, Chao M, Arumäe U, Castrén, E. (2011). Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus. Neuropharmacology, 61, 1291−1296.
1.1.
2011
Hellman, M.; Arumäe, U.; Yu, L.Y.; Lindholm, P.; Peränen, J.; Saarma, M.; Permi, P. (2011). Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons. Journal of Biological Chemistry, 286 (4), 2675−2680.
1.1.
2010
Sidorova, Y A; Mätlik, K; Paveliev, M; Lindahl, M; Piranen, E; Milbrandt, J; Arumäe, U; Saarma, M; Bespalov, M M (2010). Persephin signaling through GFRα1: The potential for the treatment of Parkinson's disease. Molecular and Cellular Neuroscience, 44 (3), 223−232.
1.1.
2008
Yu, L.Y.; Saarma, M.; Arumäe, U. (2008). Death receptors and caspases but not mitochondria are activated in the GDNF- or BDNF-deprived dopaminergic neurons. Journal of Neuroscience, 28 (30), 7467−7475.
1.1.
2008
Yu, L.Y.; Arumäe, U. (2008). Survival assay of transiently transfected dopaminergic neurons. Journal of Neuroscience Methods, 169 (1), 8−15.
1.1.
2007
Tauszig-Delamasure, S.; Yu, L. Y.; Cabrera, J. R.; Bouzas-Rodriguez, J.; Mermet-Bouvier, C.; Guix, C.; Bordeaux, M. C.; Arumäe, U.; Mehlen, P. (2007). The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. Proceedings of the National Academy of Sciences of the United States of America, 13361−13366.
1.1.
2007
Aalto, A.; Sarin, L. P.; van Dijk, A. A.; Saarma, M.; Poranen, M. M.; Arumäe, U.; Bamford, D. H. (2007). Large Scale Production of dsRNA and siRNA Pools for RNA Interference Utilizing Bacteriophage phi6 RNA-dependent RNA Polymerase. RNA, 13 (3), 422−429.
1.1.
2007
Paveliev, M.; Lume, M.; Velthut, A.; Phillips, M.; Arumäe, U.; Saarma, M. (2007). Neurotrophic factors switch between two signaling pathways that trigger axonal growth. Journal of Cell Science, 120, 2507−2516. DOI: 10.1242/jcs.003590.
1.1.
2004
Lindholm, D.; Arumäe, U. (2004). Cell differentiation: reciprocal regulation of Apaf-1 and the inhibitor of apoptosis proteins. Journal of Cell Biology, 167 (2), 193−195.
1.1.
2003
Yu, L.-Y.; Korhonen, L.; Martinez, R.; Jokitalo, E.; Chen, Y.; Arumäe, U.; Lindholm, D. (2003). Regulation of sympathetic neuron and neuroblastoma cell death by XIAP and its association with proteasomes in neural cells. Molecular and Cellular Neuroscience, 22 (3), 303−318.
1.1.
2003
Yu, Li-Ying; Jokitalo, E.; Sun, Yun-Fu; Mehlen, P.; Lindholm, D.; Saarma, Mart; Arumäe, Urmas (2003). GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway. Journal of Cell Biology, 163 (5), 987−997.
1.1.
2003
Sun, Yun-Fu; Yu, Li-Ying; Saarma, Mart; Arumäe, Urmas (2003). Mutational analysis of N-Bak reveals different structural requirements for antiapoptotic activity in neurons and proapoptotic activity in nonneuronal cells. Molecular and Cellular Neuroscience, 23 (1), 134−143.
1.1.
2002
Lindholm, D.; Mercer, E.A.; Yu, L-Y.; Chen, Y.; Kukkonen, J.; Korhonen, L.; Arumäe, U. (2002). Neuronal apoptosis inhibitory protein: Structural requirements for hippocalcin binding and effects on survival of NGF dependent sympathetic neurons. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 138−147. DOI: 10.1016/S1570-9639(02)00454-5.
1.1.
2001
Sun, Y.-F; Yu, L.-Y.; Saarma, M.; Timmusk, T.; Arumäe, U. (2001). Neuron-specific Bcl-2 homology 3 domain-only splice variant of Bak is anti-apoptotic in neurons, but pro-apoptotic in non-neuronal cells. Journal of Biological Chemistry, 276 (19), 16240−16247.
1.1.
2001
Lindahl, M.; Poteryaev, D.; Yu, L.; Arumäe, U.; Timmusk, T.; Bongarzone, I.; Aiello, A.; Pierotti, M. A.; Airaksinen, M. S.; Saarma, M. (2001). Human GFRα4 is the receptor for persephin, and is predominantly expressed in normal and malignant thyroid medullary cells. Journal of Biological Chemistry, 276 (12), 9344−9351.
1.1.
2001
Hamner, S.; Arumäe, Urmas; Li-Ying, Y.; Sun, Y.-F.; Saarma, Mart; Lindholm, D. (2001). Functional characterization of two splice variants of rat Bad and their interaction with Bcl-w in sympathetic neurons. Molecular and cellular neurosciences, 17 (1), 97−106.
1.1.
2000
Schober, A.; Arumäe, U.; Saarma, Mart; Unsicker, K. (2000). Expression of GFRa-1, GFRA-2, and c-Ret mRNAs in rat adrenal gland. Journal of neurocytology, 29 (3), 209−213.
1.1.
2000
Laurikainen, A.; Hiltunen, J.O.; Thomas-Crusells, J.; Vanhatalo, S.; Arumäe, U.; Airaksinen, M.S.; Klinge, E.; Saarma, Mart (2000). Neurturin is a neurotrophic factor for penile parasympathetic neurons in adult rat. Journal of Neurobiology, 43 (2), 198−205.
1.1.
1999
Schober, A.; Hertel, R.; Arumäe, U.; Farkas, L.; Jaszai, J.; Krieglstein, K.; Saarma, M.; Unsicker, K. (1999). GDNF rescues target-deprived sympathetic spinal cord neurons but requires TGF-β as co-factor in vivo. Journal of Neuroscience, 19 (6), 2008−2015.
1.1.
1999
Rossi, J.; Luukko, K.; Poteriaev, D.; Sun, Y.F.; Laakso, T.; Eerikäinen, S.; Tuominen, R.; Lakso, M.; Rauvala, H.; Arumäe, U.; Pasternack, M.; Saarma, M.; Airaksinen, M.S. (1999). Retarded growth and deficits in the parasympathetic nervous system in mice lacking GFRα2, a functional neurturin receptor. Neuron, 22 (2), 243−252.
1.1.
1999
Poteriaev, D.; Titievsky, A.D.; Sun, Y.F.; Thomas-Crusells, J.; Lindahl, M.; Billaud, M.; Arumäe, U.; Saarma, Mart (1999). GDNF triggers a novel Ret-independent Src-kinase family-coupled signaling via a GPI-linked GDNF receptor a[alfa]1. FEBS Letters, 463, 63−66.
1.1.
1999
Haapasalo, A.; Saarelainen, T.; Moshnyakov, M.; Arumäe, U.; Kiema, T.-R.; Saarma, Mart; Wong, G.; Castren, E. (1999). Expression of the naturally occuring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. Oncogene, 18 (6), 1285−1296.
1.1.
1997
Luukko, K.; Arumäe, U.; Karavanov, A.; Moshnyakov, M.; Sainio, K.; Sariola, H.; Saarma, M.; Thesleff, I. (1997). Neurotrophin mRNA expression in the developing tooth suggests multiple roles in innervation and organogenesis. Developmental Dynamics, 210 (2), 117−129.
1.1.
1997
Suvanto, P.; Wartiovaara, K.; Lindahl, M.; Arumäe, U.; Moshnyakov, M.; Horellikuitunen, N.; Airaksinen, M. S.; Palotie, A.; Sariola, H.; Saarma, M. (1997). Cloning, mRNA distribution and chromosomal localization of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha. Human Molecular Genetics, 6 (8), 1267−1273.
1.1.
1997
Sainio, K.; Suvanto, P.; Davies, J.; Wartiovaara, J.; Wartiovaara, K.; Saarma, M.; Arumäe, U.; Meng, X.; Lindahl, M.; Pachnis, V.; Sariola, H. (1997). Glial cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development, 124 (20), 4077−4087.
1.1.
1996
Trupp, M.; Arenas, E.; Fainzilber, M.; Nilsson, A.-S.; Sieber, B.-A.; Grigoriou, M.; Kilkenny, C.; Salazar-Crueso, E.; Pachnis, V.; Arumäe, U.; Sariola, H.; Saarma, M.; Ibáñez, C. F. (1996). Functional recptor for GDNF encoded by the c-ret proto-oncogene. Nature, 381 (6585), 785−789.
1.1.
1996
Moshnyakov, M.; Arumäe, U.; Saarma, M. (1996). mRNAs for one, two or three members of trk receptor family are expressed in single rat trigeminal ganglion neurons. Molecular Brain Research, 43, 141−148.
1.1.
1996
Hiltunen, J. O.; Arumäe, U.; Moshnyakov, M.; Saarma, M. (1996). Expression of mRNAs for neurotrophins and their receptors in developing rat heart. Circulation Research, 79 (5), 930−939.
1.1.
1996
Suvanto, P.; Hiltunen, J. O.; Arumäe, U.; Moshnyakov, M.; Sariola, H.; Sainio, K.; Saarma, M. (1996). Localization of glial cell line-derived neurotrophic factor (GDNF) mRNA in embryonic rat by in situ hybridization. European Journal of Neuroscience, 8 (4), 816−822.
1.1.
1996
Simonen, M.; Vihinen, H.; Jämsä, E.; Arumäe, U.; Kalkkinen, N.; Makarow, M. (1996). The hsp150Δ-carrier confers secretion competence to the rat nerve growth factor receptor ectodomain in Saccharomyces cerevisiae. Yeast, 12 (5), 457−466.
1.1.
1994
Pirvola, U.; Arumäe, U.; Moshnyakov, M.; Palgi, J.; Saarma, M.; Ylikoski, J. (1994). Coordinated expression and function of neurotrophic factors and their receptors in the rat inner ear during target innervation. Hearing research, 75, 131−144.
1.1.
1993
Arumäe, U.; Pirvola, U.; Palgi, J.; Kiema, T.-R.; Palm, K.; Moshnyakov, M.; Ylikoski, J.; Saarma, M. (1993). Neurotrophins and their receptors in rat peripheral trigeminal system during maxillary nerve growth. Journal of Cell Biology, 122 (5), 1053−1065.
1.1.
1993
Ylikoski, J.; Pirvola, U.; Moshnyakov, M.; Palgi, J.; Arumäe, U.; Saarma, M. (1993). Expression patterns of neurotrophin and their receptor mRNAs in the rat inner ear. Hearing research, 65, 69−78.
1.1.
1992
Pirvola, U.; Palgi, J.; Ylikoski, J.; Lehtonen, E.; Arumäe, U.; Saarma, M. (1992). Brain-derived neurotrophic factor and neurotrophin-3 mRNAs are expressed in the peripheral target fields of developing inner ear ganglia. Proceedings of the National Academy of Sciences of the United States of America, 89 (20), 9915−9919.
1.1.
1991
Sariola, H.; Saarma, M.; Sainio, K.; Arumäe, U.; Palgi, J.; Vaahtokari, A.; Thesleff, I.; Karavanov, A. (1991). Dependence of kidney morphogenesis on the expression of nerve growth factor receptor. Science, 254 (5031), 571−573.
1.1.
1991
Joachimiak, A.; Giel, M.; Otwinowski, Z.; Arumäe, U.; Siigur, J.; Saarma, M.; Sigler, P. B.; Barciszewski, J. (1991). Crystallization and preliminary X-ray analysis of nerve growth factor from Vipera lebetina. Journal of Crystal Growth, 214−219.
1.1.
1989
Arumäe, U.; Neuman, T.; Sinijärv, R.; Saarma, M. (1989). Sensitive time-resolved fluoroimmunoassay of the nerve growth factor and the disappearance of the nerve growth factor from rat pheochromocytoma PC12 cell culture medium. Journal of Immunological Methods, 122 (1), 59−65.
1.1.
1987
Glinsky, G. V., Ivanova, A. B., Vinnitsky, P. V., Arumäe, U., Siigur, J., Neuman T. (1987). NGF may be the metastase growth factor. Annals of New York Academy of Sciences, 656−659.
1.1.
1987
Arumäe, Urmas; Siigur, Jüri; Neuman, Toomas; Saarma, Mart. (1987). Monoclonal antibodies against Vipera lebetina venom nerve growth factor cross-react with other snake venom nerve growth factors. Molecular Immunology, 24 (12), 1295−1302.
1.1.
1987
Siigur, Jüri; Arumäe, Urmas; Neuman, Toomas; Siigur, Ene; Saarma, Mart (1987). Monoclonal antibody immunoaffinity chromatography of the nerve growth factor from snake venoms. Comparative Biochemistry and Physiology, 87B (2), 329−384.
1.1.
1986
Siigur, J.; Arumäe, U.; Neuman, T.; Samel, M.; Siigur, E.; Saarma, M. (1986). Isolation and characterization of nerve growth factor from Vipera berus berus (common viper) venom. Comparative Biochemistry and Physiology. B-Biochemistry and Molecular Biology, 83 (3), 621−625.

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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
MTTMTT84MANF neurotrophic factor: novel mode of action and therapeutic potential01.08.201231.10.2015Urmas ArumäeTallinna Tehnikaülikool, Matemaatika-loodusteaduskond416 001,00 EUR
PUT; PUT_OPPUT1417Neuronite ja lümfotsüütide elu ja programmeeritud surma mehhanismid 01.01.201731.12.2020Urmas ArumäeTallinna Tehnikaülikool, Loodusteaduskond, Keemia ja biotehnoloogia instituut211 200,00 EUR
PUT; PUT_OPPUT110Neuroprotektiivse peptiidi terapeutiline potentsiaal ja toimemehhanism01.01.201331.12.2016Urmas ArumäeTallinna Tehnikaülikool, Matemaatika-loodusteaduskond225 600,00 EUR