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Olen nõus

Joel Starkopf

https://www.etis.ee/CV/Joel_Starkopf/est
8.02.1966
731 8400
joel.starkopf@ut.ee
C-7538-2013

Teenistuskäik

Töökohad ja ametid
01.04.2021–...   
Tartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut, anestesioloogia ja intensiivravi professor (0,30)
2016–...   
Tartu Ülikool, kliinilise meditsiini instituudi juhataja
01.02.2004–...   
Tartu Ülikool, anestesioloogia ja intensiivravi professor (1,00)
01.01.2001–...   
Tartu Ülikool, anestesioloogia ja intensiivravi kliinik, kliiniku juhataja
01.01.2001–...   
SA Tartu Ülikooli Kliinikum, anestesioloogia ja intensiivravi kliinik, kliiniku juhataja (0,50)
2009–2016   
Tartu Ülikool, arstiteaduskonna dekaan
2001–2004   
Tartu Ülikool, Arstiteaduskond, anestesioloogia ja intensiivravi kliinik, Dotsent (1,00)
01.01.1999–31.12.2001   
Tartu Ülikooli Kliinikum, anestesioloogia ja intensiivravi kliinik, anestesioloog (0,50)
01.01.1996–31.12.2001   
Tartu Ülikool, Arstiteaduskond, anestesioloogia ja intensiivravi kliinik, assistent, vanemassistent (0,50)
01.01.1996–31.12.2001   
Tartu Ülikool, Arstiteaduskond, biokeemia instituut, assistent, vanemassistent (0,50)
01.01.1993–31.12.1999   
Tartu Maarjamõisa Haigla, Kardiokirurgia osakond; anestesioloog
 
 
Haridustee
1991–1992   
Tartu Ülikool, anestesioloogia ja intensiivravi internatuur
1991–1997   
Tartu Ülikool, doktorantuur arstiteaduskonnas
1983–1991   
Tartu Ülikool, arstiteaduskond
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2018−...   
SA Eesti Teadusagentuuri teadustaristu hindamiskomisjoni liige
2013−...   
Eesti Haigekassa ravikvaliteedi indikaatorite nõukoja esimees
2011−...   
Ajakirja Case Reports in Critical Care toimetuse liige
2010−...   
Euroopa Intensiivravi Seltsi töögrupi "Working group on abdominal problems" liige
2006−...   
Euroopa Anestesioloogide Seltsi koolitusvõrgu C.E.E.A. Continuous European Education in Anaesthesiology Eesti keskuse direktor
2005−...   
Euroopa Intensiivravi Seltsi liige
2004−...   
Euroopa Anestesioloogia Ühingu liige
2001−...   
SA Tartu Kiirabi nõukogu liige
2000−...   
EV Sotsiaalministeeriumi erialakomisjoni liige
2006−2017   
Anestesioloogia ja intensiivravi residentuuri üldjuhendaja, Tartu Ülikool
2003−2009   
Eesti Anestesioloogide Seltsi president
2000−2012   
Eesti Anestesioloogide Seltsi juhatuse liige

Kvalifikatsioon

Teaduskraadid
Joel Starkopf, doktorikraad, 1997, (juh) Mihkel Zilmer, Oxidative stress and ischaemia-reperfusion of the heart: a clinical and experimental study, Tartu Ülikool, Arstiteaduskond.
 
 
Teaduspreemiad ja tunnustused
2018, Joel Starkopf, Eesti riigi teaduspreemia arstiteaduse alal (koos A. Reintam Blaseriga) teemal "Kõhuõõnesisese rõhu tõus ja seedetrakti puudulikkus intensiivravi haigetel".
2018, Joel Starkopf, Tartu Ülikooli aasta õppejõud
2016, Joel Starkopf, Tartu Ülikooli aasta tudengisõber (üliõpilasorganisatsioonide tunnustus)
2015, Joel Starkopf, Tartu Ülikooli suur medal
2015, Joel Starkopf, Eesti Arstide Liidu aumärk
2011, Joel Starkopf, Eesti Arstiteaduse Üliõpilaste Seltsi auliige
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 3. Terviseuuringud; 3.7. Kliiniline meditsiin; CERCS KLASSIFIKAATOR: B590 Anestesioloogia, intensiivravi ; TÄPSUSTUS: Oksüdatiivne stress ja südamelihase isheemia-reperfusioon, hüperoksia kardioprotektiivne toime., Gastrointestinaalne puudulikkus ja intra-abdominaalne hüpertensioon intensiivravi haigetel. , Taaselustamise kaugtulemused ja elukvaliteet., Antibiootikumide farmakokineetika intensiivravi haigetel.

Jooksvad projektid

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

1.1. Teadusartiklid, mis on kajastatud Web of Science andmebaasides Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index ja/või andmebaasis Scopus (v.a. kogumikud)
 
Hallik, Maarja; Ilmoja, Mari-Liis; Standing, Joseph F; Soeorg, Hiie; Jalas, Tiiu; Raidmäe, Maila; Uibo, Karin; Köbas, Kristel; Sõnajalg, Margit; Takkis, Kalev; Veigure, Rūta; Kipper, Karin; Starkopf, Joel; Metsvaht, Tuuli (2020). Population Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates on the First Days of Life. British Journal of Clinical Pharmacology, 86 (2), 318−328. DOI: 10.1111/bcp.14146.
 
Kepler, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Vähi, Mare; Kals, Jaak (2020). Remote ischaemic preconditioning attenuates cardiac biomarkers during vascular surgery: a randomised clinical trial. European Journal of Vascular and Endovascular Surgery, 59 (2), 301−308. DOI: 10.1016/j.ejvs.2019.09.502.
 
Kasepalu, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Vähi, Mare; Kals, Jaak (2020). Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation: A Randomised Trial. Oxidative Medicine and Cellular Longevity, 2020, ARTN 7098505. DOI: 10.1155/2020/7098505.
 
Kasepalu, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Vähi, Mare; Kals, Jaak (2020). Remote ischaemic preconditioning influences the levels of acylcarnitines in vascular surgery: a randomised clinical trial. Nutrition & Metabolism. DOI: 10.1186/s12986-020-00495-3.
 
Keskpaik, Triinu; Starkopf, Joel; Kirsimägi, Ülle; Mihnovitš, Vladislav; Lomp, Andrus; Raamat, Eeva-Maarja; Saar, Sten; Talving, Peep. (2020). The role of elevated high-sensitivity cardiac troponin on outcomes following severe blunt chest trauma. Injury, 51 (5), 1177−1182. DOI: 10.1016/j.injury.2019.12.037.
 
Kepler, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Lieberg, Juri; Vahi, Mare; Kals, Jaak (2019). The Effect of Remote Ischaemic Preconditioning on Arterial Stiffness in Patients Undergoing Vascular Surgery: A Randomised Clinical Trial. European Journal of Vascular and Endovascular Surgery, 57 (6), 868−875. DOI: 10.1016/j.ejvs.2018.12.002.
 
Hallik, Maarja; Ilmoja, Mari-Liis; Tasa, Tõnis; Standing, Joseph F.; Takkis, Kalev; Veigure, Rūta; Kipper, Karin; Jalas, Tiiu; Raidmäe, Maila; Uibo, Karin; Starkopf, Joel; Metsvaht, Tuuli (2019). Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants. Pediatric Critical Care Medicine, 20 (7), 621−629. DOI: 10.1097/PCC.0000000000001879.
 
Reintam Blaser A, Regli A, De Keulenaer B, Kimball EJ, Starkopf L, Davis WA, Greiffenstein P, Starkopf J; Incidence, Risk Factors, and Outcomes of Intra-Abdominal (IROI) Study Investigators. (2019). Incidence, Risk Factors, and Outcomes of Intra-Abdominal Hypertension in Critically Ill Patients-A Prospective Multicenter Study (IROI Study). Critical Care Medicine, 47 (4), 535−542.10.1097/CCM.0000000000003623.
 
Eltermaa, Mall; Jakobson, Maili; Utt, Meeme; Kõks, Sulev; Mägi, Reedik; Starkopf, Joel (2019). Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease. BMC Research Notes, 12 (1), 759−759. DOI: 10.1186/s13104-019-4807-x.
 
Reintam Blaser, Annika; Deane, Adam M.; Starkopf, Joel (2019). Translating the European Society for Clinical Nutrition and Metabolism 2019 guidelines into practice. Current Opinion in Critical Care, 25 (4), 314−321.10.1097/MCC.0000000000000619.
 
Padar, Martin; Starkopf, Joel; Uusvel, Gerli; Blaser, Annika Reintam (2019). Gastrointestinal failure affects outcome of intensive care. Journal of Critical Care, 52, 103−108. DOI: 10.1016/j.jcrc.2019.04.001.
 
Padar, Martin; Blaser, Annika Reintam; Talving, Peep; Lipping, Edgar; Starkopf, Joel (2019). Abdominal Compartment Syndrome: Improving Outcomes With A Multidisciplinary Approach - A Narrative Review. Journal of Multidisciplinary Healthcare, 12, 1061−1074. DOI: 10.2147/JMDH.S205608.
 
Moonen, P.J.; Reintam Blaser, A; Starkopf, J.; Oudemans-van Straaten H.M.; Van der Mullen, J.; Vermeulen, G.; Malbrain, MLNG. (2018). The black box revelation: monitoring gastrointestinal function. Anaesthesiology Intensive Therapy, 50 (1), 72−81. DOI: 10.5603/AIT.a2017.0065.
 
Reintam Blaser, Annika; Starkopf, Joel; Moonen, Pieter-Jan; Malbrain, Manu LNG; Oudemans-van Straaten, Heleen M (2018). Perioperative gastrointestinal problems in the ICU. Anaesthesiology Intensive Therapy, 50 (1). DOI: 10.5603/AIT.a2017.0064.
 
Hallik, Maarja; Tasa, Tõnis; Starkopf, Joel; Metsvaht, Tuuli (2017). Dosing of Milrinone in Preterm Neonates to Prevent Postligation Cardiac Syndrome: Simulation Study Suggests Need for Bolus Infusion. Neonatology, 111 (1), 8−11. DOI: 10.1159/000447049.
 
Reintam Blaser A, Starkopf J, Alhazzani W, Berger MM, Casaer MP, Deane AM, Fruhwald S, Hiesmayr M, Ichai C, Jakob SM, Loudet CI, Malbrain ML, Montejo González JC, Paugam-Burtz C, Poeze M, Preiser JC, Singer P, van Zanten AR, De Waele J, Wendon J, Wernerman J, Whitehouse T, Wilmer A, Oudemans-van Straaten HM; ESICM Working Group on Gastrointestinal Function. (2017). Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Medicine, 43 (3), 380−389.10.1007/s00134-016-4665-0.
 
Saar, Sten; Sokirjanski, Maksim; Junkin, Liina-Kadi; Laos, Juhan; Laar, Anu-Liis; Merioja, Ingrid; Lepner, Urmas; Kukk, Leonhard; Remmelgas, Andrus; Asser, Toomas; Innos, Kaire; Starkopf, Joel; Talving, Peep. (2017). Evolution of severe trauma in Estonia comparing early versus established independence of the state. European Journal of Trauma and Emergency Surgery, 43 (6), 791−796. DOI: 10.1007/s00068-016-0731-0.
 
Sakr, Yasser; Birri, Paolo Nahuel Rubatto; Kotfis, Katarzyna; Nanchal, Rahul; Shah, Bhagyesh; Kluge, Stefan; Schroeder, Mary E.; Marshall, John C.; Vincent, Jean-Louis (2017). Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit. Critical Care Medicine, 45 (3), 386−394. DOI: 10.1097/CCM.0000000000002189.
 
Tamme, K.; Oselin, K.; Kipper, K.; Tasa, T.; Metsvaht, T.; Karjagin, J; Herodes, K.; Kern, H.; Starkopf J. (2016). Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam during high volume haemodiafiltration in patients with septic shock. Acta Anaesthesiologica Scandinavica, 60 (2), 230−240. DOI: 10.1111/aas.12629.
 
Kuslapuu, M.; Jõgela, K.; Starkopf, J.; Reintam Blaser, A. (2015). The reasons for insufficient enteral feeding in an intensive care unit: A prospective observational study. Intensive and Critical Care Nursing, 31 (5), 309−314.10.1016/j.iccn.2015.03.001.
 
Reintam Blaser, A.; Starkopf, J.; Malbrain, ML. (2015). Abdominal signs and symptoms in intensive care patients. Anaesthesiology Intensive Therapy, 47 (4), 379−387. DOI: 10.5603/AIT.a2015.0022.
 
Tamme, K.; Maddison, L.; Kruusat, R.; Ehrlich, H.E.; Viirelaid, M.; Kern, H.; Starkopf, J. (2015). Effects of High Volume Haemodiafiltration on Inflammatory Response Profile and Microcirculation in Patients with Septic Shock. BioMed Research International, 4, 125615.10.1155/2015/125615.
 
Tamme, K.; Oselin, K.; Kipper, K.; Low, K.; Standing, JF.; Metsvaht, T.; Karjagin, J.; Herodes, K.; Kern, H.; Starkopf, J. (2015). Pharmacokinetics of doripenem during high volume hemodiafiltration in patients with septic shock. Journal of Clinical Pharmacology, 55 (4), 438−446. DOI: 10.1002/jcph.432.
 
Klek, S.; Krznaric, Z.; Gundogdu, RH.; Chourdakis, M.; Kekstas, G.; Jakobson, T.; Paluszkiewicz, P.; Vranesic Bender, D.; Uyar, M.; Demirag, K.; Poulia, KA.; Klimasauskas, A.; Starkopf, J.; Galas, A. (2015). The Prevalence of Malnutrition in Various Political, Economic, and Geographic Settings. Journal of Parenteral and Enteral Nutrition, 39 (2), 200−210.10.1177/0148607113505860.
 
Reintam Blaser, A.; Starkopf, L.; Deane, AM.; Poeze, M.; Starkopf, J. (2015). Comparison of different definitions of feeding intolerance: A retrospective observational study. Clinical Nutrition, 34 (5), 956−961.10.1016/j.clnu.2014.10.006.
 
Gustot, T.; Felleiter, P.; Pickkers, P.; Sakr, Y.; Rello, J.; Velissaris, D.; Pierrakos, C.; Taccone, FS.; Sevcik, P.; Moreno, C.; Vincent, JL.; EPIC II Group of Investigators Autorite grupp:Reintam Blsaser, A.; Starkopf, J. (2014). Impact of infection on the prognosis of critically ill cirrhotic patients: results from a large worldwide study. Liver International, 34 (10), 1496−1503. DOI: 10.1111/liv.12520.
 
Vincent, JL.; Marshall, JC.; Namendys-Silva, SA.; François, B.; Martin-Loeches, I.; Lipman, J.; Reinhart, K.; Antonelli, M.; Pickkers, P.; Njimi, H.; Jimenez, E.; Sakr, Y.; ICON investigators. Autorite grupp:Starkopf, J. (2014). Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. The Lancet Respiratory Medicine, 2 (5), 380−386.10.1016/S2213-2600(14)70061-X.
 
De Waele, J.; Lipman, J.; Sakr, Y.; Marshall, JC.; Vanhems, P.; Barrera Groba, C.; Leone, M.; Vincent, JL.; EPIC II Investigators Autorite grupp: Reintam Blsaser, A.; Starkopf, J. (2014). Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome. BMC Infectious Diseases, 14, 420.10.1186/1471-2334-14-420.
 
Maddison, L.; Riigor, KM.; Karjagin, J.; Starkopf, J. (2014). Sublingual microcirculatory changes during transient intra-abdominal hypertension--a prospective observational study in laparoscopic surgery patients. Clinical Hemorheology and Microcirculation, 57 (4), 367−374.10.3233/CH-131791.
 
Maddison, L.; Karjagin, J.; Tenhunen, J.; Kirsimägi, U.; Starkopf, J. (2014). Moderate intra-abdominal hypertension leads to anaerobic metabolism in the rectus abdominis muscle tissue of critically ill patients: a prospective observational study. BioMed Research International, 857492.10.1155/2014/857492.
 
Jakobson, T.; Karjagin, J.; Vipp, L.; Padar, M.; Parik, AH.; Starkopf, L.; Kern, H.; Tammik, O.; Starkopf, J. (2014). Postoperative complications and mortality after major gastrointestinal surgery. Medicina (Kaunas), 50 (2), 111−117.10.1016/j.medici.2014.06.002.
 
Reintam Blaser, Annika; Starkopf, Joel; Kirsimägi, Ülle; Deane, Adam (2014). Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis. Acta Anaesthesiologica Scandinavica, 58 (8), 914−922.10.1111/aas.12302.
 
Lehmann, C.; Abdo, I.; Kern, H.; Maddison, L.; Pavlovic, D.; Sharawi, N; Starkopf, J.; Hall, R.; Johnson, P.; Williams, L; Cerny, V. (2014). Clinical evaluation of the intestinal microcirculation using sidestream dark field imaging - Recommendations of a round table meeting. Clinical Hemorheology and Microcirculation, 57 (2), 137−146.10.3233/CH-141810.
 
Malbrain, ML.; Chiumello, D.; Cesana, BM.; Reintam Blaser, A.; Starkopf, J.; Sugrue, M.; Pelosi, P.; Severgnini, P.; Hernandez, G.; Brienza, N.; Kirkpatrick, AW.; Schachtrupp, A.; Kempchen, J.; Estenssoro, E.; Vidal, MG.; De Laet, I.; De Keulenaer, BL. (2014). A Systematic Review And Individual Patient Data Meta-Analysis On Intraabdominal Hypertension In Critically Ill Patients: The Wake-Up Project World Initiative on Abdominal Hypertension Epidemiology, a Unifying Project (WAKE-Up!). Minerva Anestesiologica, 80 (3), 293−306.
 
Maddison, L.; Karjagin, J.; Buldakov, M.; Mäll, M.; Kruusat, R.; Lillemäe, K.; Kirsimägi, Ü.; Starkopf, J. (2014). Sublingual microcirculation in patients with intra-abdominal hypertension: a pilot study in 15 critically ill patients. Journal of Critical Care, 29 (1), 183.e1.10.1016/j.jcrc.2013.08.018.
 
Reintam Blaser, A.; Sarapuu, S.; Tamme, K.; Starkopf, J. (2014). Expanded measurements of intra-abdominal pressure do not increase the detection rate of intra-abdominal hypertension: a single-center observational study. Critical Care Medicine, 42 (2), 378−386.10.1097/CCM.0b013e3182a6459b.
 
Bero, Lisa A.; Hill, Suzanne; Habicht, Jarno; Mathiesen, Mari; Starkopf, Joel (2013). The updated clinical guideline development process in Estonia is an efficient method for developing evidence-based guidelines. Journal of Clinical Epidemiology, 66 (2), 132−139.10.1016/j.jclinepi.2012.07.007.
 
Holodinsky, JK.; Roberts, DJ.; Ball, CG.; Reintam Blaser, A.; Starkopf, J.; Zygun, DA.; Stelfox, HT.; Malbrain, ML.; Jaeschke, RC.; Kirkpatrick, AW. (2013). Risk factors for intra-abdominal hypertension and abdominal compartment syndrome among adult intensive care unit patients: a systematic review and meta-analysis. Critical Care, 17 (5), 249.10.1186/cc13075.
 
Karu, I.; Starkopf, J.; Zilmer, K.; Zilmer, M. (2013). Growth factors serum levels in coronary artery disease patients scheduled for bypass surgery: perioperative dynamics and comparisons with healthy volunteers. BioMed Research International, 5 pages.
 
Reintam Blaser, Annika; Starkopf, Joel (2013). Management of intensive care patients with open abdomen: evidence warranted. Minerva Anestesiologica, 79 (4), 339−341.
 
Reintam Blaser, Annika; Poeze, Martijn; Malbrain, Manu; Björck, Martin; Oudemans-van Straaten, Helena-Maria; Starkopf, Joel (2013). Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study. Intensive Care Medicine, 39 (5), 899−909.10.1007/s00134-013-2831-1.
 
Jakobson, T.; Svitškar, N.; Tamme, K.; Starkopf, J.; Karjagin, J. (2012). Two Cases of Takotsubo Syndrome Related to Tracheal Intubation/Extubation. Medicina (Kaunas), 48 (2), 77−79.
 
Reintam Blaser, A.; Malbrain, ML.; Starkopf, J.; Fruhwald, S.; Jakob, SM.; De Waele, J.; Braun, JP.; Poeze, M.; Spies, C. (2012). Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Medicine, 38 (3), 384−394.10.1007/s00134-011-2459-y.
 
Karu, Inga; Tähepõld, Peeter; Ruusalepp, Arno; Zilmer, Kersti; Zilmer, Mihkel; Starkopf, Joel (2012). Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury. Journal of Negative Results in Biomedicine, 11 (14), 14. DOI: 10.1186/1477-5751-11-14.
 
Hallik, M.; Tamme, K.; Väli, T.; Starkopf, J. (2011). Successful liver transplantation after 21 days of hepatic coma. Journal of American Society of Artificial Internal Organs, 57 (6), 545−546. DOI: 10.1097/MAT.0b013e318230632e.
 
Bullock, A.; Wilde, JD.; Bion, JF.; Bion, J.; Bullock, A.; Clutton-Brock, T.; Flaatten, H.; Mathy, B.; Van Mook, W.; Schuwirth, L.; Marsh, B.; Phelan, D.; Shippey, B.; Nimmo, G.; Castel, S.; Hillion, Y.; Bonnet, J.; Chaumont, D.; Rothen, HU.; Reay, H. ... Ramsay, G. (2011). International standards for programmes of training in intensive care medicine in Europe. Intensive Care Medicine, 37 (3), 385−393.10.1007/s00134-010-2096-x.
 
Kett, DH.; Azoulay, E.; Echeverria, PM.; Vincent, JL.; Group authors incl. Starkopf, J. (2011). Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Critical Care Medicine, Apr; 39 (4), 665−670.
 
Reintam Blaser, A.; Parm, P.; Kitus, R.; Starkopf, J. (2011). Risk factors for intra-abdominal hypertension in mechanically ventilated patients. Acta Anaesthesiologica Scandinavica, 55 (5), 607−614.
 
Karu, I.; Tähepõld, P.; Ruusalepp, A.; Starkopf, J. (2010). Pretreatment by hyperoxia – a tool to reduce ischaemia-reperfusion injury in the myocardium. Current Clinical Pharmacology, 5 (2), 125−132. DOI: 10.2174/157488410791110788.
 
Karu, I.; Taal, G.; Zilmer, K.; Pruunsild, C.; Starkopf, J.; Zilmer, M. (2010). Inflammatory/oxidative stress during the first week after different types of cardiac surgery. Scandinavian Cardiovascular Journal, 44 (2), 119−124. DOI: 10.3109/14017430903490981.
 
Wilde, J.D.; Bion, J.F.; Bullock, A.; Bion, J.; Wilde, J.D.; Clutton-Brock, T.; Bullock, A.; Flaatten, H.; Mathy, N.; Van Mook, W.; Schuwirth, L.; Marsh, B.; Phelan, D.; Shippey, B.; Nimmo, G.; Castel, S.; Hillion, Y.; Frot, J.; Bonnet, J.; Rothen, H. ... Reay, H. (2009). The educational environment for training in intensive care medicine: structures, processes, outcomes and challenges in the European region. Intensive Care Medicine, 35 (9), 1575−1583. DOI: 10.1007/s00134-009-1514-4.
 
Reintam, A.; Parm, P.; Kitus, R.; Kern, H.; Starkopf, J. (2009). Gastrointestinal symptoms in intensive care patients. Acta Anaesthesiol. Scand., 53 (3), 318−324. DOI: 10.1111/j.1399-6576.2008.01860.x.
 
Reinhard, Veronika; Pärna, Kersti; Lang, Katrin; Pisarev, Heti; Sipria, Aleksander; Starkopf, Joel (2009). Long-term outcome of bystander-witnessed out-of-hospital cardiac arrest in Estonia from 1999 to 2002. Resuscitation, 80 (1), 73−78. DOI: 10.1016/j.resuscitation.2008.08.012.
 
Karu, I.; Tähepõld, P.; Sulling, TA.; Alver, M.; Zilmer, M.; Starkopf, J. (2009). Off-pump coronary surgery causes immediate release of myocardial damage markers. Asian Cardiovascular and Thoracic Annals, 17 (5), 494−499.
 
Reintam, A.; Parm, P.; Kitus, R.; Kern, H.; Starkopf, J. (2008). Primary and secondary intra-abdominal hypertension-different impact on ICU outcome. Intensive Care Medicine, 34 (9), 1624−1631. DOI: 10.1007/s00134-008-1134-4.
 
Reintam, A.; Parm, P.; Kitus, R.; Starkopf, J.; Kern, H. (2008). Gastrointestinal Failure score in critically ill patients: a prospective observational study. Critical Care, 12 (4), R90. DOI: 10.1186/cc6958.
 
Karjagin, J.; Lefeuvre, S.; Oselin, K.; Kipper, K.; Marchand, S.; Tikkerberi, A.; Starkopf, J.; Couet, W.; Sawchuk, R.J. (2008). Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock. Clinical Pharmacology & Therapeutics, 83 (3), 452−459. DOI: 10.1038/sj.clpt.6100312.
 
Kals, J.; Starkopf, J.; Zilmer, M.; Pruler, T.; Pulges, K.; Hallaste, M.; Kals, M.; Pulges, A.; Soomets, U. (2008). Antioxidant UPF1 attenuates myocardial stunning in isolated rat hearts. International Journal of Cardiology, 125 (1), 133−135. DOI: 10.1016/j.ijcard.2007.01.032.
 
Reintam, A.; Kern, H.; Starkopf, J. (2007). Defining gastrointestinal failure. Acta Clinica Belgica, 62, 168−172.
 
Karu, I.; Loit, R.; Zilmer, K.; Kairane, C.; Paapstel, A.; Zilmer, M.; Starkopf, J. (2007). Pre-treatment with hyperoxia before coronary artery bypass grafting – effects upon myocardial injury and inflammatory response. Acta Anaesthesiologica Scandinavica, 51 (10), 1305−1313.
 
Karu, I.; Zilmer, K.; Starkopf, J.; Zilmer, M. (2006). Changes of plasma asymmetric dimethylarginine levels after coronary artery bypass grafting. Scandinavian Cardiovascular Journal, 40 (6), 363−367.
 
Reintam, A.; Parm, P.; Redlich, U.; Tooding, L.M.; Starkopf, J.; Kohler, F.; Spies, C.; Kern, H. (2006). Gastrointestinal failure in intensive care: a retrospective clinical study in three different intensive care units in Germany and Estonia. BMC Gastroenterology, 6 (19), 1−7.
 
Starkopf, J.; Hegna, S.; Johanson, EO.; Munch-Ellingsen, J.; Mjøs, O.; Ytrehus, K. (2006). In vivo chronic carvedilol treatment in rats attenuates ex vivo regional infarction of the heart. Scandinavian Cardiovascular Journal, 40 (4), 240−247.
 
Karu, I.; Loit, R.; Paapstel, A.; Kairane, C.; Zilmer, M.; Starkopf, J. (2005). Early postoperative function of the heart after coronary artery bypass grafting is not predicted by myocardial necrosis and glutathione-associated oxidative stress. Clinica Chimica Acta, 359, 195−202.
 
Karjagin, J; Pähkla, R; Karki, T; Starkopf, J. (2005). Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro. Journal of Antimicrobial Chemotherapy, 55 (3), 341−346.
 
Poder, P.; Zilmer, M.; Starkopf, J.; Kals, J.; Talonpoika, A.; Pulges, A.; Langel, U.; Kullisaar, T.; Viirlaid, S.; Mahlapuu, R.; Zarkovski, A.; Arend, A.; Soomets, U. (2004). An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. Neuroscience Letters, 370 (1), 45−50.
 
Karjagin, J.; Pahkla, R.; Starkopf, J. (2004). Perioperative penetration of metronidazole into muscle tissue: a microdialysis study. European Journal of Clinical Pharmacology, 59 (11), 809−813.
 
Angdin, M.; Settergren, G.; Starkopf, J.; Zilmer, M.; Zilmer, K.; Vaage, J. (2003). Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia, 17 (3), 314−320.
 
Tahepold, P.; Vaage, J.; Starkopf, J.; Valen, G. (2003). Hyperoxia elicits myocardial protection through a nuclear factor kappa B-dependent mechanism in the rat heart. Journal of Thoracic and Cardiovascular Surgery, 125 (3), 650−660.
 
Tahepold, P.; Eha, I.; Kals, J.; Taal, G.; Talonpoika, A.; Valen, G.; Vaage, J.; Starkopf, J. (2002). Exposure of rats to hyperoxia enhances relaxation of isolated aortic rings and reduces infarct size of isolated hearts. Acta Physiologica Scandinavica, 175 (4), 271−277.
 
Tähepõld, P.; Ruusalepp, A.; Li, G.; Vaage, J.; Starkopf, J.; Valen, G. (2002). Cardioprotection by breathing hyperoxic gas - relation to oxygen concentration and exposure time in rats and mice. European Journal of Cardio-Thoracic Surgery, 21 (6), 987−994.
 
Tahepold, P.; Valen, G.; Starkopf, J.; Kairane, C.; Zilmer, M.; Vaage, J. (2001). Pretreating rats with hyperoxia attenuates ischemia-reperfusion injury of the heart. Life Sciences, 68 (14), 1629−1640.
 
Valen, G.; Kawakami, T.; Tahepold, P.; Starkopf, J.; Kairane, C.; Dumitrescu, A.; Lowbeer, C.; Zilmer, M.; Vaage, J. (2000). Pretreatment with methylprednisolone protects the isolated rat heart against ischaemic and oxidative damage. Free Radical Research, 33 (1), 31−43.
 
Starkopf, J.; Andreasen, TV.; Bugge, E.; Ytrehus, K. (1998). Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. Cardiovascular Research, 37 (1), 66−75.
 
Valen, G.; Starkopf, J.; Takeshima, S.; Kullisaar, T.; Vihalemm, T.; Kengsepp, AT.; Lowbeer, C.; Vaage, J.; Zilmer, M. (1998). Preconditioning with hydrogen peroxide (H2O2) or ischemia in H2O2-induced cardiac dysfunction. Free Radical Research, 29 (3), 235−245.
 
Starkopf, J.; Bugge, E.; Ytrehus, K. (1997). Preischaemic bradykinin and ischaemic preconditioning in functional recovery of the globally ischaemic rat heart. Cardiovascular Research, 33 (1), 63−70.
 
Starkopf, J.; Tamme, K.; Zilmer, M.; Talvik, R.; Samarutel, J. (1997). The evidence of oxidative stress in cardiac surgery and septic patients: A comparative study. Clinica Chimica Acta, 262, 77−88.
 
Starkopf, J.; Zilmer, K.; Vihalemm, T.; Kullisaar, T.; Zilmer, M.; Samarutel, J. (1995). Time course of oxidative stress during open-heart surgery. Scandinavian Journal of Thoracic and Cardiovascular Surgery, 29 (4), 181−186.
1.2. Teadusartiklid teistes rahvusvahelistes teadusajakirjades, millel on registreeritud kood, rahvusvaheline toimetus, rahvusvahelise kolleegiumiga eelretsenseerimine, rahvusvaheline levik ning kättesaadavus ja avatus kaastöödele
 
Lass, Jana; Tamme, Kadri; Kipper, Karin; Starkopf, Joel (2017). Dosing of Ertapenem in an Extreme Obesity: A Case Report of 250 kg Patient. Case Reports in Critical Care, 1−3. DOI: 10.1155/2017/5310768.
 
Padar, Martin; Uusvel, Gerli; Starkopf, Liis; Starkopf, Joel; Reintam Blaser, Annika (2017). Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study. World Journal of Critical Care Medicine, 6 (1), 56−64. DOI: 10.5492/wjccm.v6.i1.56.
 
Maddison, Liivi; Starkopf, Joel; Reintam Blaser, Annika (2016). Mild to moderate intra-abdominal hypertension: Does it matter? World Journal of Critical Care Medicine, 5 (1), 96−102. DOI: 10.5492/wjccm.v5.i1.96.
 
Starkopf, J.; Tamme, K.; Blaser, A.R (2012). Should we measure intra-abdominal pressures in every intensive care patient? Annals of Intensive Care, 2 (1), S9.
 
Maddison Liivi,Karjagin Juri, Tenhunen Jyrki, Starkopf Joel (2012). Moderate intra-abdominal hypertension is associated with an increased lactate-pyruvate ratio in the rectus abdominis muscle tissue: a pilot study during laparoscopic surgery. Annals of Intensive Care, 2, S14. DOI: 10.1186/2110-5820-2-S1-S14.
 
Reintam Blaser, A.; Parm, P.; Kitus, R.; Starkopf, J. (2011). Intra-abdominal hypertension and gastrointestinal symptoms in mechanically ventilated patients. Critical Care Research and Practice, 2011, 982507. DOI: 10.1155/2011/982507.
 
Metsvaht, T.; Hermlin, T.; Kern, H.; Kahre, T.; Starkopf, J. (2006). Aortic Arch Thrombosis in a Neonate With Heterozygous Carrier Status of Factor V Leiden Mutation. Congenital Heart Disease, 1, 40−45.
1.3. Eelretsenseeritud teadusartiklid Eesti ja teiste riikide eelretsenseeritavates teadusajakirjades, millel on kohalik toimetuskolleegium, või eelretsenseeritud teadusartiklid Eesti kultuurile olulistes ajakirjades või teadusartiklid ajakirjades Akadeemia, Looming ja Vikerkaar.
 
Kroon, H.; Eltermaa, M.; Reigo, A.; Karu, I.; Ruusalepp, A.; Starkopf, J.; Kõks, S. (2017). Humaniin – väike peptiid, suured ülesanded? Ülevaateartikkel humaniini-nimelisest peptiidist. Eesti Arst, 96 (6), 328−333.
 
Fedossov, V.; Kirsimägi, Ü.; Starkopf, J.; Reintam Blaser, A. (2015). Mao jääkmahu mõõtmine intensiivravihaigetel. Eesti Arst, 94 (4), 40−45.
 
Teele Kepler, Karl Kuusik, Jaan Eha, Mihkel Zilmer, Urmas Lepner, Joel Starkopf, Jaak Kals (2015). Kaugisheemiline eelkohastamine – lihtne meetod elundikahjustuse vähendamiseks. Eesti Arst, 94 (11), 661−666.
 
Mathiesen, M.; Starkopf, J.; Habicht, J. (2011). Eesti ravijuhendite koostamise süsteem on ajakohastatud ja uus käsiraamat valminud. Eesti Arst, 8, 364−365.
 
Starkopf, J. (2011). Arstiteaduskond 2011/2012. õppeaasta hakul. Eesti Arst, 8, 355−356.
 
Koroljov, A.; Starkopf, J.; Reintam, A. (2010). Seedetraktipuudulikkuse levimus aparaadihingamisel intensiivravihaigetel. Eesti Arst, 89 (11), 708−716.
 
Lepner, U.; Murruste, M.; Vaasna, T.; Starkopf, J.; Nõmm, K.; Kadastik, Ü.; Kirss, F.; Majass, M.; Värimäe, E.-A. (2009). Ägeda kõhuvaluga haige käsitlus. Ravijuhend. Eesti Arst, 209−227.
 
Maddison Liivi, Tamme Kadri, Kitus Reet, Reintam Annika, Starkopf Joel (2009). Abdominaalse kompartmentsündroomi levimus ning ravitulemused TÜ Kliinikumi üldintensiivravi osakonnas aastatel 2004–2006. Eesti Arst, 234−241.
 
Starkopf, J. (2009). Arstiteaduskond uue õppeaasta hakul. Eesti Arst, 88 (9), 563−564.
 
Maddisson, L.; Tamme, K.; Kitus, R.; Reintam, A.; Starkopf, J. (2009). Abdominaalse kompartmentsündroomi esinemissagedus ning ravitulemused Tartu Ülikooli Kliinikumi üldintensiivravi osakonnas aastatel 2004 kuni 2006. Eesti Arst, 88 (4), 234−241.
 
Reintam, A.; Parm, P.; Kitus, R.; Tamme, K.; Starkopf, J. (2008). Intra-abdominaalse hüpertensiooni esinemissagedus intensiivravi haigetel ja mõju ravitulemustele. Eesti Arst, 87 (3), 191−197.
 
Starkopf, Joel (2008). Intensiivravi eile, täna ja homme. Eesti Arst, 87 (11), 830−831.
 
Reintam, A.; Parm, P.; Kitus, R.; Kern, H.; Starkopf, J. (2007). Gastrointestinal failure. Acta Medica Lituanica, 10, 36−37.
 
Starkopf, J. (2007). Use of scoring systems in intensive care. Acta Medica Lituanica, 10, 62−64.
 
Karjagin, J.; Pähkla, R.; Starkopf, J. (2004). Metronidasooli kontsentratsioon septilises šokis olevate patsientide vereplasmas ja lihaskoes. Eesti Arst, 83 (2), 87−92.
 
Reintam, A.; O'Konnel, N.; Jekimov, H.; Starkopf, J. (2004). Tsentraalvenoosse rõhu interpretatsioon sepsisega intensiivravihaigetel. Eesti Arst, 83 (3), 168−172.
 
Tähepõld, P.; Ruusalepp, A.; Zilmer, M.; Valen, G.; Vaage, J.; Starkopf, J. (2003). Hüperoksia - kas uus võimalus südamelihase kaitseks? Eesti Arst, 1, 22-28.
2.2. Monograafiad (sisestatud enne 1. juulit 2014. a.)
 
Soomets, U; Starkopf, J; Zilmer, Mihkel; Karelson, Ello-Rahel; Vihalemm, Tiiu; Zilmer, K; Valkna, A; Sillard, R; Langel, Ü (1996). Bioorganic chemistry for medical students. Tartu: Tartu University.
2.3. Dissertatsioonide seerias ilmunud dissertatsioonid (v.a. käsikirjalised);
 
Starkopf, J. (1997). Oxidative stress and ischaemia-reperfusion of the heart. A clinical and experimental study. (Doktoritöö, University of Tartu, University of Tromso). Tartu: Tartu University Press.
3.1. Artiklid/peatükid lisas loetletud kirjastuste välja antud kogumikes (kaasa arvatud Web of Science Book Citation Index, Web of Science Conference Proceedings Citation Index, Scopus refereeritud kogumikud)
 
Valen, G.; Tähepôld, P.; Starkopf, J.; Ruusalepp, A.; Vaage, J. (2003). Adaptation to ischemia by hyperoxia-signalling through mitogen activated protein kinases and nuclear factor kappa B. In: Dhalla, N.; Hryshko, L.; Kardami, E.; Singal, P.V. (Ed.). Signal transduction and cardiac hypertrophy (461−477). . Boston: Kluwer Academic Publishers.
 
Kokk, K.; Starkopf, J.; Sipria, A.; Zilmer, M.; Talvik, R. (1995). Compared evidence of oxidative stress in SIRS and cardiac surgery patients. Proceedings of 8th European Congress of Intensive Care Medicine, Athens: 8th European Congress of Intensive Care Medicine, Athens, 1995. , 69−73.
5.2. Konverentsiteesid, mis ei kuulu valdkonda 5.1
 
Eltermaa, Mall; Jakobson, Maili; Utt, Meeme; Kõks, Sulev; Mägi, Reedik; Starkopf, Joel (2019). Geneetilistel variantidel humaniini nukleaarsete isovormide geenides ei ole statistiliselt olulist seost koronaararteri haigusega. Eesti Arst, 98. OÜ Celsius Healthcare, 36−36.
6.2. Õpikud ja muud õppeotstarbelised publikatsioonid, v.a. kõrgkooliõpikud;
 
Starkopf, J.; Jekimov, H.; Karjagin, J.; Reinhard, V.; Saar, T.; Sõrmus, A.; Tamme, K.; Tähepõld, P. (2008). Valitud peatükke anestesioloogiast ja intensiivravist I. . Tartu Ülikooli Kirjastus.
 
Soomets, U.; Zilmer, M.; Starkopf, J.; Karelson, E.-R.; Vihalemm, T.; Zilmer, K.; Sillard, R.; Bourne, J; Langel, Ü. (1999). Selected knowledge for medical biochemistry. Tartu: Tartu Ülikooli Kirjastus.
9.07.2021

Joel Starkopf

https://www.etis.ee/CV/Joel_Starkopf/eng
8.02.1966
731 8400
joel.starkopf@ut.ee
http://
C-7538-2013

Career

Institutions and positions
01.04.2021–...   
University of Tartu, Faculty of Medicine, Institute of Clinical Medicine, Professor of Anaesthesiology and Intensive Care (0,30)
2016–...   
University of Tartu, Institute of Clinical Medicine, Head of Institute
01.02.2004–...   
University of Tartu, Professor of Anaesthesiology and Intensive Care (1,00)
01.01.2001–...   
University of Tartu, Department of Anaesthesiology and Intensive Care, Head of Department
01.01.2001–...   
Tartu University Hospital, Department of Anaesthesiology and Intensive Care, Head of Department (0,50)
2009–2016   
University of Tartu, Dean of Medical Faculty
2001–2004   
University of Tartu, Faculty of Medicine, Department of Anesthesiology and Intensive Care, associate professor (1,00)
01.01.1999–31.12.2001   
Tartu University Hospital, Department of Anaesthesiology and Intensive Care, anaesthesiologist (0,50)
01.01.1996–31.12.2001   
University of Tartu, Faculty of Medicine, Department of Anaesthesiology and Intensive Care, assistant, senior assistant (0,50)
01.01.1996–31.12.2001   
University of Tartu, Faculty of Medicine, Institute of Biochemistry, assistant, senior assistant (0,50)
01.01.1993–31.12.1999   
Tartu Maarjamõisa Hospital, Department of Cardiac Surgery; anaesthesiologist
 
 
Education
1991–1992   
University of Tartu, internship in anaesthesiology and intensive care
1991–1997   
University of Tartu, PhD in Medicine
1983–1991   
University of Tartu, Faculty of Medicine, MD
 
 
R&D related managerial and administrative work
2011−...   
Case Reports in Critical Care, member of editorial team
2010−...   
Active member of European Society of Intensive Care Medicine Working Group on Abdominal Problems
2006−...   
Committee for European Education in Anaesthesia (CEEA) Centre Director, Tartu, Estonia
2005−...   
Member of European Society of Intensive Care
2004−...   
Member of European Society of Anaesthesiology
2000−...   
Estonian Ministry of Social Affairs, member of expert committee in anaesthesiology
2003−2009   
President of the Society of Estonian Anaesthesiologists
2000−2012   
Board member of the Society of Estonian Anaesthesiologists

Qualifications

Academic degrees
Joel Starkopf, Doctor's Degree, 1997, (sup) Mihkel Zilmer, Oxidative stress and ischaemia-reperfusion of the heart: a clinical and experimental study (Oxidative stress and ischaemia-reperfusion of the heart: a clinical and experimental study), University of Tartu, Faculty of Medicine.
 
 
Honours & awards
2018, Joel Starkopf, Estonian State Prize in Medical Science (with A. Reintam Blaser) on "Intra-abdominal pressure and gastrointestinal failure in intensive care patients".
 
 
Fields of research
ETIS CLASSIFICATION: 3. Health; 3.7. Clinical Medicine; CERCS CLASSIFICATION: B590 Anaesthesiology, intensive care ; SPECIFICATION: Oxidative stress and ischaemia-reperfusion of the heart. Cardioprotection by hyperoxia., Gastrointestinal failure and intra-abdominal hypertension in critically ill patients., Long-term outcome after resuscitation from cardiac arrest., Pharmacokinetics of antimicrobial drugs in critically ill patients.
 
 

Projects in progress

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

1.1. Teadusartiklid, mis on kajastatud Web of Science andmebaasides Science Citation Index Expanded, Social Sciences Citation Index, Arts & Humanities Citation Index, Emerging Sources Citation Index ja/või andmebaasis Scopus (v.a. kogumikud)
 
Hallik, Maarja; Ilmoja, Mari-Liis; Standing, Joseph F; Soeorg, Hiie; Jalas, Tiiu; Raidmäe, Maila; Uibo, Karin; Köbas, Kristel; Sõnajalg, Margit; Takkis, Kalev; Veigure, Rūta; Kipper, Karin; Starkopf, Joel; Metsvaht, Tuuli (2020). Population Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates on the First Days of Life. British Journal of Clinical Pharmacology, 86 (2), 318−328. DOI: 10.1111/bcp.14146.
 
Kepler, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Vähi, Mare; Kals, Jaak (2020). Remote ischaemic preconditioning attenuates cardiac biomarkers during vascular surgery: a randomised clinical trial. European Journal of Vascular and Endovascular Surgery, 59 (2), 301−308. DOI: 10.1016/j.ejvs.2019.09.502.
 
Kasepalu, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Vähi, Mare; Kals, Jaak (2020). Remote Ischaemic Preconditioning Reduces Kidney Injury Biomarkers in Patients Undergoing Open Surgical Lower Limb Revascularisation: A Randomised Trial. Oxidative Medicine and Cellular Longevity, 2020, ARTN 7098505. DOI: 10.1155/2020/7098505.
 
Kasepalu, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Vähi, Mare; Kals, Jaak (2020). Remote ischaemic preconditioning influences the levels of acylcarnitines in vascular surgery: a randomised clinical trial. Nutrition & Metabolism. DOI: 10.1186/s12986-020-00495-3.
 
Keskpaik, Triinu; Starkopf, Joel; Kirsimägi, Ülle; Mihnovitš, Vladislav; Lomp, Andrus; Raamat, Eeva-Maarja; Saar, Sten; Talving, Peep. (2020). The role of elevated high-sensitivity cardiac troponin on outcomes following severe blunt chest trauma. Injury, 51 (5), 1177−1182. DOI: 10.1016/j.injury.2019.12.037.
 
Kepler, Teele; Kuusik, Karl; Lepner, Urmas; Starkopf, Joel; Zilmer, Mihkel; Eha, Jaan; Lieberg, Juri; Vahi, Mare; Kals, Jaak (2019). The Effect of Remote Ischaemic Preconditioning on Arterial Stiffness in Patients Undergoing Vascular Surgery: A Randomised Clinical Trial. European Journal of Vascular and Endovascular Surgery, 57 (6), 868−875. DOI: 10.1016/j.ejvs.2018.12.002.
 
Hallik, Maarja; Ilmoja, Mari-Liis; Tasa, Tõnis; Standing, Joseph F.; Takkis, Kalev; Veigure, Rūta; Kipper, Karin; Jalas, Tiiu; Raidmäe, Maila; Uibo, Karin; Starkopf, Joel; Metsvaht, Tuuli (2019). Population Pharmacokinetics and Dosing of Milrinone After Patent Ductus Arteriosus Ligation in Preterm Infants. Pediatric Critical Care Medicine, 20 (7), 621−629. DOI: 10.1097/PCC.0000000000001879.
 
Reintam Blaser A, Regli A, De Keulenaer B, Kimball EJ, Starkopf L, Davis WA, Greiffenstein P, Starkopf J; Incidence, Risk Factors, and Outcomes of Intra-Abdominal (IROI) Study Investigators. (2019). Incidence, Risk Factors, and Outcomes of Intra-Abdominal Hypertension in Critically Ill Patients-A Prospective Multicenter Study (IROI Study). Critical Care Medicine, 47 (4), 535−542.10.1097/CCM.0000000000003623.
 
Eltermaa, Mall; Jakobson, Maili; Utt, Meeme; Kõks, Sulev; Mägi, Reedik; Starkopf, Joel (2019). Genetic variants in humanin nuclear isoform gene regions show no association with coronary artery disease. BMC Research Notes, 12 (1), 759−759. DOI: 10.1186/s13104-019-4807-x.
 
Reintam Blaser, Annika; Deane, Adam M.; Starkopf, Joel (2019). Translating the European Society for Clinical Nutrition and Metabolism 2019 guidelines into practice. Current Opinion in Critical Care, 25 (4), 314−321.10.1097/MCC.0000000000000619.
 
Padar, Martin; Starkopf, Joel; Uusvel, Gerli; Blaser, Annika Reintam (2019). Gastrointestinal failure affects outcome of intensive care. Journal of Critical Care, 52, 103−108. DOI: 10.1016/j.jcrc.2019.04.001.
 
Padar, Martin; Blaser, Annika Reintam; Talving, Peep; Lipping, Edgar; Starkopf, Joel (2019). Abdominal Compartment Syndrome: Improving Outcomes With A Multidisciplinary Approach - A Narrative Review. Journal of Multidisciplinary Healthcare, 12, 1061−1074. DOI: 10.2147/JMDH.S205608.
 
Moonen, P.J.; Reintam Blaser, A; Starkopf, J.; Oudemans-van Straaten H.M.; Van der Mullen, J.; Vermeulen, G.; Malbrain, MLNG. (2018). The black box revelation: monitoring gastrointestinal function. Anaesthesiology Intensive Therapy, 50 (1), 72−81. DOI: 10.5603/AIT.a2017.0065.
 
Reintam Blaser, Annika; Starkopf, Joel; Moonen, Pieter-Jan; Malbrain, Manu LNG; Oudemans-van Straaten, Heleen M (2018). Perioperative gastrointestinal problems in the ICU. Anaesthesiology Intensive Therapy, 50 (1). DOI: 10.5603/AIT.a2017.0064.
 
Hallik, Maarja; Tasa, Tõnis; Starkopf, Joel; Metsvaht, Tuuli (2017). Dosing of Milrinone in Preterm Neonates to Prevent Postligation Cardiac Syndrome: Simulation Study Suggests Need for Bolus Infusion. Neonatology, 111 (1), 8−11. DOI: 10.1159/000447049.
 
Reintam Blaser A, Starkopf J, Alhazzani W, Berger MM, Casaer MP, Deane AM, Fruhwald S, Hiesmayr M, Ichai C, Jakob SM, Loudet CI, Malbrain ML, Montejo González JC, Paugam-Burtz C, Poeze M, Preiser JC, Singer P, van Zanten AR, De Waele J, Wendon J, Wernerman J, Whitehouse T, Wilmer A, Oudemans-van Straaten HM; ESICM Working Group on Gastrointestinal Function. (2017). Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Medicine, 43 (3), 380−389.10.1007/s00134-016-4665-0.
 
Saar, Sten; Sokirjanski, Maksim; Junkin, Liina-Kadi; Laos, Juhan; Laar, Anu-Liis; Merioja, Ingrid; Lepner, Urmas; Kukk, Leonhard; Remmelgas, Andrus; Asser, Toomas; Innos, Kaire; Starkopf, Joel; Talving, Peep. (2017). Evolution of severe trauma in Estonia comparing early versus established independence of the state. European Journal of Trauma and Emergency Surgery, 43 (6), 791−796. DOI: 10.1007/s00068-016-0731-0.
 
Sakr, Yasser; Birri, Paolo Nahuel Rubatto; Kotfis, Katarzyna; Nanchal, Rahul; Shah, Bhagyesh; Kluge, Stefan; Schroeder, Mary E.; Marshall, John C.; Vincent, Jean-Louis (2017). Higher Fluid Balance Increases the Risk of Death From Sepsis: Results From a Large International Audit. Critical Care Medicine, 45 (3), 386−394. DOI: 10.1097/CCM.0000000000002189.
 
Tamme, K.; Oselin, K.; Kipper, K.; Tasa, T.; Metsvaht, T.; Karjagin, J; Herodes, K.; Kern, H.; Starkopf J. (2016). Pharmacokinetics and pharmacodynamics of piperacillin/tazobactam during high volume haemodiafiltration in patients with septic shock. Acta Anaesthesiologica Scandinavica, 60 (2), 230−240. DOI: 10.1111/aas.12629.
 
Kuslapuu, M.; Jõgela, K.; Starkopf, J.; Reintam Blaser, A. (2015). The reasons for insufficient enteral feeding in an intensive care unit: A prospective observational study. Intensive and Critical Care Nursing, 31 (5), 309−314.10.1016/j.iccn.2015.03.001.
 
Reintam Blaser, A.; Starkopf, J.; Malbrain, ML. (2015). Abdominal signs and symptoms in intensive care patients. Anaesthesiology Intensive Therapy, 47 (4), 379−387. DOI: 10.5603/AIT.a2015.0022.
 
Tamme, K.; Maddison, L.; Kruusat, R.; Ehrlich, H.E.; Viirelaid, M.; Kern, H.; Starkopf, J. (2015). Effects of High Volume Haemodiafiltration on Inflammatory Response Profile and Microcirculation in Patients with Septic Shock. BioMed Research International, 4, 125615.10.1155/2015/125615.
 
Tamme, K.; Oselin, K.; Kipper, K.; Low, K.; Standing, JF.; Metsvaht, T.; Karjagin, J.; Herodes, K.; Kern, H.; Starkopf, J. (2015). Pharmacokinetics of doripenem during high volume hemodiafiltration in patients with septic shock. Journal of Clinical Pharmacology, 55 (4), 438−446. DOI: 10.1002/jcph.432.
 
Klek, S.; Krznaric, Z.; Gundogdu, RH.; Chourdakis, M.; Kekstas, G.; Jakobson, T.; Paluszkiewicz, P.; Vranesic Bender, D.; Uyar, M.; Demirag, K.; Poulia, KA.; Klimasauskas, A.; Starkopf, J.; Galas, A. (2015). The Prevalence of Malnutrition in Various Political, Economic, and Geographic Settings. Journal of Parenteral and Enteral Nutrition, 39 (2), 200−210.10.1177/0148607113505860.
 
Reintam Blaser, A.; Starkopf, L.; Deane, AM.; Poeze, M.; Starkopf, J. (2015). Comparison of different definitions of feeding intolerance: A retrospective observational study. Clinical Nutrition, 34 (5), 956−961.10.1016/j.clnu.2014.10.006.
 
Gustot, T.; Felleiter, P.; Pickkers, P.; Sakr, Y.; Rello, J.; Velissaris, D.; Pierrakos, C.; Taccone, FS.; Sevcik, P.; Moreno, C.; Vincent, JL.; EPIC II Group of Investigators Autorite grupp:Reintam Blsaser, A.; Starkopf, J. (2014). Impact of infection on the prognosis of critically ill cirrhotic patients: results from a large worldwide study. Liver International, 34 (10), 1496−1503. DOI: 10.1111/liv.12520.
 
Vincent, JL.; Marshall, JC.; Namendys-Silva, SA.; François, B.; Martin-Loeches, I.; Lipman, J.; Reinhart, K.; Antonelli, M.; Pickkers, P.; Njimi, H.; Jimenez, E.; Sakr, Y.; ICON investigators. Autorite grupp:Starkopf, J. (2014). Assessment of the worldwide burden of critical illness: the intensive care over nations (ICON) audit. The Lancet Respiratory Medicine, 2 (5), 380−386.10.1016/S2213-2600(14)70061-X.
 
De Waele, J.; Lipman, J.; Sakr, Y.; Marshall, JC.; Vanhems, P.; Barrera Groba, C.; Leone, M.; Vincent, JL.; EPIC II Investigators Autorite grupp: Reintam Blsaser, A.; Starkopf, J. (2014). Abdominal infections in the intensive care unit: characteristics, treatment and determinants of outcome. BMC Infectious Diseases, 14, 420.10.1186/1471-2334-14-420.
 
Maddison, L.; Riigor, KM.; Karjagin, J.; Starkopf, J. (2014). Sublingual microcirculatory changes during transient intra-abdominal hypertension--a prospective observational study in laparoscopic surgery patients. Clinical Hemorheology and Microcirculation, 57 (4), 367−374.10.3233/CH-131791.
 
Maddison, L.; Karjagin, J.; Tenhunen, J.; Kirsimägi, U.; Starkopf, J. (2014). Moderate intra-abdominal hypertension leads to anaerobic metabolism in the rectus abdominis muscle tissue of critically ill patients: a prospective observational study. BioMed Research International, 857492.10.1155/2014/857492.
 
Jakobson, T.; Karjagin, J.; Vipp, L.; Padar, M.; Parik, AH.; Starkopf, L.; Kern, H.; Tammik, O.; Starkopf, J. (2014). Postoperative complications and mortality after major gastrointestinal surgery. Medicina (Kaunas), 50 (2), 111−117.10.1016/j.medici.2014.06.002.
 
Reintam Blaser, Annika; Starkopf, Joel; Kirsimägi, Ülle; Deane, Adam (2014). Definition, prevalence, and outcome of feeding intolerance in intensive care: a systematic review and meta-analysis. Acta Anaesthesiologica Scandinavica, 58 (8), 914−922.10.1111/aas.12302.
 
Lehmann, C.; Abdo, I.; Kern, H.; Maddison, L.; Pavlovic, D.; Sharawi, N; Starkopf, J.; Hall, R.; Johnson, P.; Williams, L; Cerny, V. (2014). Clinical evaluation of the intestinal microcirculation using sidestream dark field imaging - Recommendations of a round table meeting. Clinical Hemorheology and Microcirculation, 57 (2), 137−146.10.3233/CH-141810.
 
Malbrain, ML.; Chiumello, D.; Cesana, BM.; Reintam Blaser, A.; Starkopf, J.; Sugrue, M.; Pelosi, P.; Severgnini, P.; Hernandez, G.; Brienza, N.; Kirkpatrick, AW.; Schachtrupp, A.; Kempchen, J.; Estenssoro, E.; Vidal, MG.; De Laet, I.; De Keulenaer, BL. (2014). A Systematic Review And Individual Patient Data Meta-Analysis On Intraabdominal Hypertension In Critically Ill Patients: The Wake-Up Project World Initiative on Abdominal Hypertension Epidemiology, a Unifying Project (WAKE-Up!). Minerva Anestesiologica, 80 (3), 293−306.
 
Maddison, L.; Karjagin, J.; Buldakov, M.; Mäll, M.; Kruusat, R.; Lillemäe, K.; Kirsimägi, Ü.; Starkopf, J. (2014). Sublingual microcirculation in patients with intra-abdominal hypertension: a pilot study in 15 critically ill patients. Journal of Critical Care, 29 (1), 183.e1.10.1016/j.jcrc.2013.08.018.
 
Reintam Blaser, A.; Sarapuu, S.; Tamme, K.; Starkopf, J. (2014). Expanded measurements of intra-abdominal pressure do not increase the detection rate of intra-abdominal hypertension: a single-center observational study. Critical Care Medicine, 42 (2), 378−386.10.1097/CCM.0b013e3182a6459b.
 
Bero, Lisa A.; Hill, Suzanne; Habicht, Jarno; Mathiesen, Mari; Starkopf, Joel (2013). The updated clinical guideline development process in Estonia is an efficient method for developing evidence-based guidelines. Journal of Clinical Epidemiology, 66 (2), 132−139.10.1016/j.jclinepi.2012.07.007.
 
Holodinsky, JK.; Roberts, DJ.; Ball, CG.; Reintam Blaser, A.; Starkopf, J.; Zygun, DA.; Stelfox, HT.; Malbrain, ML.; Jaeschke, RC.; Kirkpatrick, AW. (2013). Risk factors for intra-abdominal hypertension and abdominal compartment syndrome among adult intensive care unit patients: a systematic review and meta-analysis. Critical Care, 17 (5), 249.10.1186/cc13075.
 
Karu, I.; Starkopf, J.; Zilmer, K.; Zilmer, M. (2013). Growth factors serum levels in coronary artery disease patients scheduled for bypass surgery: perioperative dynamics and comparisons with healthy volunteers. BioMed Research International, 5 pages.
 
Reintam Blaser, Annika; Starkopf, Joel (2013). Management of intensive care patients with open abdomen: evidence warranted. Minerva Anestesiologica, 79 (4), 339−341.
 
Reintam Blaser, Annika; Poeze, Martijn; Malbrain, Manu; Björck, Martin; Oudemans-van Straaten, Helena-Maria; Starkopf, Joel (2013). Gastrointestinal symptoms during the first week of intensive care are associated with poor outcome: a prospective multicentre study. Intensive Care Medicine, 39 (5), 899−909.10.1007/s00134-013-2831-1.
 
Jakobson, T.; Svitškar, N.; Tamme, K.; Starkopf, J.; Karjagin, J. (2012). Two Cases of Takotsubo Syndrome Related to Tracheal Intubation/Extubation. Medicina (Kaunas), 48 (2), 77−79.
 
Reintam Blaser, A.; Malbrain, ML.; Starkopf, J.; Fruhwald, S.; Jakob, SM.; De Waele, J.; Braun, JP.; Poeze, M.; Spies, C. (2012). Gastrointestinal function in intensive care patients: terminology, definitions and management. Recommendations of the ESICM Working Group on Abdominal Problems. Intensive Care Medicine, 38 (3), 384−394.10.1007/s00134-011-2459-y.
 
Karu, Inga; Tähepõld, Peeter; Ruusalepp, Arno; Zilmer, Kersti; Zilmer, Mihkel; Starkopf, Joel (2012). Effects of 60 minutes of hyperoxia followed by normoxia before coronary artery bypass grafting on the inflammatory response profile and myocardial injury. Journal of Negative Results in Biomedicine, 11 (14), 14. DOI: 10.1186/1477-5751-11-14.
 
Hallik, M.; Tamme, K.; Väli, T.; Starkopf, J. (2011). Successful liver transplantation after 21 days of hepatic coma. Journal of American Society of Artificial Internal Organs, 57 (6), 545−546. DOI: 10.1097/MAT.0b013e318230632e.
 
Bullock, A.; Wilde, JD.; Bion, JF.; Bion, J.; Bullock, A.; Clutton-Brock, T.; Flaatten, H.; Mathy, B.; Van Mook, W.; Schuwirth, L.; Marsh, B.; Phelan, D.; Shippey, B.; Nimmo, G.; Castel, S.; Hillion, Y.; Bonnet, J.; Chaumont, D.; Rothen, HU.; Reay, H. ... Ramsay, G. (2011). International standards for programmes of training in intensive care medicine in Europe. Intensive Care Medicine, 37 (3), 385−393.10.1007/s00134-010-2096-x.
 
Kett, DH.; Azoulay, E.; Echeverria, PM.; Vincent, JL.; Group authors incl. Starkopf, J. (2011). Candida bloodstream infections in intensive care units: analysis of the extended prevalence of infection in intensive care unit study. Critical Care Medicine, Apr; 39 (4), 665−670.
 
Reintam Blaser, A.; Parm, P.; Kitus, R.; Starkopf, J. (2011). Risk factors for intra-abdominal hypertension in mechanically ventilated patients. Acta Anaesthesiologica Scandinavica, 55 (5), 607−614.
 
Karu, I.; Tähepõld, P.; Ruusalepp, A.; Starkopf, J. (2010). Pretreatment by hyperoxia – a tool to reduce ischaemia-reperfusion injury in the myocardium. Current Clinical Pharmacology, 5 (2), 125−132. DOI: 10.2174/157488410791110788.
 
Karu, I.; Taal, G.; Zilmer, K.; Pruunsild, C.; Starkopf, J.; Zilmer, M. (2010). Inflammatory/oxidative stress during the first week after different types of cardiac surgery. Scandinavian Cardiovascular Journal, 44 (2), 119−124. DOI: 10.3109/14017430903490981.
 
Wilde, J.D.; Bion, J.F.; Bullock, A.; Bion, J.; Wilde, J.D.; Clutton-Brock, T.; Bullock, A.; Flaatten, H.; Mathy, N.; Van Mook, W.; Schuwirth, L.; Marsh, B.; Phelan, D.; Shippey, B.; Nimmo, G.; Castel, S.; Hillion, Y.; Frot, J.; Bonnet, J.; Rothen, H. ... Reay, H. (2009). The educational environment for training in intensive care medicine: structures, processes, outcomes and challenges in the European region. Intensive Care Medicine, 35 (9), 1575−1583. DOI: 10.1007/s00134-009-1514-4.
 
Reintam, A.; Parm, P.; Kitus, R.; Kern, H.; Starkopf, J. (2009). Gastrointestinal symptoms in intensive care patients. Acta Anaesthesiol. Scand., 53 (3), 318−324. DOI: 10.1111/j.1399-6576.2008.01860.x.
 
Reinhard, Veronika; Pärna, Kersti; Lang, Katrin; Pisarev, Heti; Sipria, Aleksander; Starkopf, Joel (2009). Long-term outcome of bystander-witnessed out-of-hospital cardiac arrest in Estonia from 1999 to 2002. Resuscitation, 80 (1), 73−78. DOI: 10.1016/j.resuscitation.2008.08.012.
 
Karu, I.; Tähepõld, P.; Sulling, TA.; Alver, M.; Zilmer, M.; Starkopf, J. (2009). Off-pump coronary surgery causes immediate release of myocardial damage markers. Asian Cardiovascular and Thoracic Annals, 17 (5), 494−499.
 
Reintam, A.; Parm, P.; Kitus, R.; Kern, H.; Starkopf, J. (2008). Primary and secondary intra-abdominal hypertension-different impact on ICU outcome. Intensive Care Medicine, 34 (9), 1624−1631. DOI: 10.1007/s00134-008-1134-4.
 
Reintam, A.; Parm, P.; Kitus, R.; Starkopf, J.; Kern, H. (2008). Gastrointestinal Failure score in critically ill patients: a prospective observational study. Critical Care, 12 (4), R90. DOI: 10.1186/cc6958.
 
Karjagin, J.; Lefeuvre, S.; Oselin, K.; Kipper, K.; Marchand, S.; Tikkerberi, A.; Starkopf, J.; Couet, W.; Sawchuk, R.J. (2008). Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock. Clinical Pharmacology & Therapeutics, 83 (3), 452−459. DOI: 10.1038/sj.clpt.6100312.
 
Kals, J.; Starkopf, J.; Zilmer, M.; Pruler, T.; Pulges, K.; Hallaste, M.; Kals, M.; Pulges, A.; Soomets, U. (2008). Antioxidant UPF1 attenuates myocardial stunning in isolated rat hearts. International Journal of Cardiology, 125 (1), 133−135. DOI: 10.1016/j.ijcard.2007.01.032.
 
Reintam, A.; Kern, H.; Starkopf, J. (2007). Defining gastrointestinal failure. Acta Clinica Belgica, 62, 168−172.
 
Karu, I.; Loit, R.; Zilmer, K.; Kairane, C.; Paapstel, A.; Zilmer, M.; Starkopf, J. (2007). Pre-treatment with hyperoxia before coronary artery bypass grafting – effects upon myocardial injury and inflammatory response. Acta Anaesthesiologica Scandinavica, 51 (10), 1305−1313.
 
Karu, I.; Zilmer, K.; Starkopf, J.; Zilmer, M. (2006). Changes of plasma asymmetric dimethylarginine levels after coronary artery bypass grafting. Scandinavian Cardiovascular Journal, 40 (6), 363−367.
 
Reintam, A.; Parm, P.; Redlich, U.; Tooding, L.M.; Starkopf, J.; Kohler, F.; Spies, C.; Kern, H. (2006). Gastrointestinal failure in intensive care: a retrospective clinical study in three different intensive care units in Germany and Estonia. BMC Gastroenterology, 6 (19), 1−7.
 
Starkopf, J.; Hegna, S.; Johanson, EO.; Munch-Ellingsen, J.; Mjøs, O.; Ytrehus, K. (2006). In vivo chronic carvedilol treatment in rats attenuates ex vivo regional infarction of the heart. Scandinavian Cardiovascular Journal, 40 (4), 240−247.
 
Karu, I.; Loit, R.; Paapstel, A.; Kairane, C.; Zilmer, M.; Starkopf, J. (2005). Early postoperative function of the heart after coronary artery bypass grafting is not predicted by myocardial necrosis and glutathione-associated oxidative stress. Clinica Chimica Acta, 359, 195−202.
 
Karjagin, J; Pähkla, R; Karki, T; Starkopf, J. (2005). Distribution of metronidazole in muscle tissue of patients with septic shock and its efficacy against Bacteroides fragilis in vitro. Journal of Antimicrobial Chemotherapy, 55 (3), 341−346.
 
Poder, P.; Zilmer, M.; Starkopf, J.; Kals, J.; Talonpoika, A.; Pulges, A.; Langel, U.; Kullisaar, T.; Viirlaid, S.; Mahlapuu, R.; Zarkovski, A.; Arend, A.; Soomets, U. (2004). An antioxidant tetrapeptide UPF1 in rats has a neuroprotective effect in transient global brain ischemia. Neuroscience Letters, 370 (1), 45−50.
 
Karjagin, J.; Pahkla, R.; Starkopf, J. (2004). Perioperative penetration of metronidazole into muscle tissue: a microdialysis study. European Journal of Clinical Pharmacology, 59 (11), 809−813.
 
Angdin, M.; Settergren, G.; Starkopf, J.; Zilmer, M.; Zilmer, K.; Vaage, J. (2003). Protective effect of antioxidants on pulmonary endothelial function after cardiopulmonary bypass. Journal of Cardiothoracic and Vascular Anesthesia, 17 (3), 314−320.
 
Tahepold, P.; Vaage, J.; Starkopf, J.; Valen, G. (2003). Hyperoxia elicits myocardial protection through a nuclear factor kappa B-dependent mechanism in the rat heart. Journal of Thoracic and Cardiovascular Surgery, 125 (3), 650−660.
 
Tahepold, P.; Eha, I.; Kals, J.; Taal, G.; Talonpoika, A.; Valen, G.; Vaage, J.; Starkopf, J. (2002). Exposure of rats to hyperoxia enhances relaxation of isolated aortic rings and reduces infarct size of isolated hearts. Acta Physiologica Scandinavica, 175 (4), 271−277.
 
Tähepõld, P.; Ruusalepp, A.; Li, G.; Vaage, J.; Starkopf, J.; Valen, G. (2002). Cardioprotection by breathing hyperoxic gas - relation to oxygen concentration and exposure time in rats and mice. European Journal of Cardio-Thoracic Surgery, 21 (6), 987−994.
 
Tahepold, P.; Valen, G.; Starkopf, J.; Kairane, C.; Zilmer, M.; Vaage, J. (2001). Pretreating rats with hyperoxia attenuates ischemia-reperfusion injury of the heart. Life Sciences, 68 (14), 1629−1640.
 
Valen, G.; Kawakami, T.; Tahepold, P.; Starkopf, J.; Kairane, C.; Dumitrescu, A.; Lowbeer, C.; Zilmer, M.; Vaage, J. (2000). Pretreatment with methylprednisolone protects the isolated rat heart against ischaemic and oxidative damage. Free Radical Research, 33 (1), 31−43.
 
Starkopf, J.; Andreasen, TV.; Bugge, E.; Ytrehus, K. (1998). Lipid peroxidation, arachidonic acid and products of the lipoxygenase pathway in ischaemic preconditioning of rat heart. Cardiovascular Research, 37 (1), 66−75.
 
Valen, G.; Starkopf, J.; Takeshima, S.; Kullisaar, T.; Vihalemm, T.; Kengsepp, AT.; Lowbeer, C.; Vaage, J.; Zilmer, M. (1998). Preconditioning with hydrogen peroxide (H2O2) or ischemia in H2O2-induced cardiac dysfunction. Free Radical Research, 29 (3), 235−245.
 
Starkopf, J.; Bugge, E.; Ytrehus, K. (1997). Preischaemic bradykinin and ischaemic preconditioning in functional recovery of the globally ischaemic rat heart. Cardiovascular Research, 33 (1), 63−70.
 
Starkopf, J.; Tamme, K.; Zilmer, M.; Talvik, R.; Samarutel, J. (1997). The evidence of oxidative stress in cardiac surgery and septic patients: A comparative study. Clinica Chimica Acta, 262, 77−88.
 
Starkopf, J.; Zilmer, K.; Vihalemm, T.; Kullisaar, T.; Zilmer, M.; Samarutel, J. (1995). Time course of oxidative stress during open-heart surgery. Scandinavian Journal of Thoracic and Cardiovascular Surgery, 29 (4), 181−186.
1.2. Teadusartiklid teistes rahvusvahelistes teadusajakirjades, millel on registreeritud kood, rahvusvaheline toimetus, rahvusvahelise kolleegiumiga eelretsenseerimine, rahvusvaheline levik ning kättesaadavus ja avatus kaastöödele
 
Lass, Jana; Tamme, Kadri; Kipper, Karin; Starkopf, Joel (2017). Dosing of Ertapenem in an Extreme Obesity: A Case Report of 250 kg Patient. Case Reports in Critical Care, 1−3. DOI: 10.1155/2017/5310768.
 
Padar, Martin; Uusvel, Gerli; Starkopf, Liis; Starkopf, Joel; Reintam Blaser, Annika (2017). Implementation of enteral feeding protocol in an intensive care unit: Before-and-after study. World Journal of Critical Care Medicine, 6 (1), 56−64. DOI: 10.5492/wjccm.v6.i1.56.
 
Maddison, Liivi; Starkopf, Joel; Reintam Blaser, Annika (2016). Mild to moderate intra-abdominal hypertension: Does it matter? World Journal of Critical Care Medicine, 5 (1), 96−102. DOI: 10.5492/wjccm.v5.i1.96.
 
Starkopf, J.; Tamme, K.; Blaser, A.R (2012). Should we measure intra-abdominal pressures in every intensive care patient? Annals of Intensive Care, 2 (1), S9.
 
Maddison Liivi,Karjagin Juri, Tenhunen Jyrki, Starkopf Joel (2012). Moderate intra-abdominal hypertension is associated with an increased lactate-pyruvate ratio in the rectus abdominis muscle tissue: a pilot study during laparoscopic surgery. Annals of Intensive Care, 2, S14. DOI: 10.1186/2110-5820-2-S1-S14.
 
Reintam Blaser, A.; Parm, P.; Kitus, R.; Starkopf, J. (2011). Intra-abdominal hypertension and gastrointestinal symptoms in mechanically ventilated patients. Critical Care Research and Practice, 2011, 982507. DOI: 10.1155/2011/982507.
 
Metsvaht, T.; Hermlin, T.; Kern, H.; Kahre, T.; Starkopf, J. (2006). Aortic Arch Thrombosis in a Neonate With Heterozygous Carrier Status of Factor V Leiden Mutation. Congenital Heart Disease, 1, 40−45.
1.3. Eelretsenseeritud teadusartiklid Eesti ja teiste riikide eelretsenseeritavates teadusajakirjades, millel on kohalik toimetuskolleegium, või eelretsenseeritud teadusartiklid Eesti kultuurile olulistes ajakirjades või teadusartiklid ajakirjades Akadeemia, Looming ja Vikerkaar.
 
Kroon, H.; Eltermaa, M.; Reigo, A.; Karu, I.; Ruusalepp, A.; Starkopf, J.; Kõks, S. (2017). Humaniin – väike peptiid, suured ülesanded? Ülevaateartikkel humaniini-nimelisest peptiidist. Eesti Arst, 96 (6), 328−333.
 
Fedossov, V.; Kirsimägi, Ü.; Starkopf, J.; Reintam Blaser, A. (2015). Mao jääkmahu mõõtmine intensiivravihaigetel. Eesti Arst, 94 (4), 40−45.
 
Teele Kepler, Karl Kuusik, Jaan Eha, Mihkel Zilmer, Urmas Lepner, Joel Starkopf, Jaak Kals (2015). Kaugisheemiline eelkohastamine – lihtne meetod elundikahjustuse vähendamiseks. Eesti Arst, 94 (11), 661−666.
 
Mathiesen, M.; Starkopf, J.; Habicht, J. (2011). Eesti ravijuhendite koostamise süsteem on ajakohastatud ja uus käsiraamat valminud. Eesti Arst, 8, 364−365.
 
Starkopf, J. (2011). Arstiteaduskond 2011/2012. õppeaasta hakul. Eesti Arst, 8, 355−356.
 
Koroljov, A.; Starkopf, J.; Reintam, A. (2010). Seedetraktipuudulikkuse levimus aparaadihingamisel intensiivravihaigetel. Eesti Arst, 89 (11), 708−716.
 
Lepner, U.; Murruste, M.; Vaasna, T.; Starkopf, J.; Nõmm, K.; Kadastik, Ü.; Kirss, F.; Majass, M.; Värimäe, E.-A. (2009). Ägeda kõhuvaluga haige käsitlus. Ravijuhend. Eesti Arst, 209−227.
 
Maddison Liivi, Tamme Kadri, Kitus Reet, Reintam Annika, Starkopf Joel (2009). Abdominaalse kompartmentsündroomi levimus ning ravitulemused TÜ Kliinikumi üldintensiivravi osakonnas aastatel 2004–2006. Eesti Arst, 234−241.
 
Starkopf, J. (2009). Arstiteaduskond uue õppeaasta hakul. Eesti Arst, 88 (9), 563−564.
 
Maddisson, L.; Tamme, K.; Kitus, R.; Reintam, A.; Starkopf, J. (2009). Abdominaalse kompartmentsündroomi esinemissagedus ning ravitulemused Tartu Ülikooli Kliinikumi üldintensiivravi osakonnas aastatel 2004 kuni 2006. Eesti Arst, 88 (4), 234−241.
 
Reintam, A.; Parm, P.; Kitus, R.; Tamme, K.; Starkopf, J. (2008). Intra-abdominaalse hüpertensiooni esinemissagedus intensiivravi haigetel ja mõju ravitulemustele. Eesti Arst, 87 (3), 191−197.
 
Starkopf, Joel (2008). Intensiivravi eile, täna ja homme. Eesti Arst, 87 (11), 830−831.
 
Reintam, A.; Parm, P.; Kitus, R.; Kern, H.; Starkopf, J. (2007). Gastrointestinal failure. Acta Medica Lituanica, 10, 36−37.
 
Starkopf, J. (2007). Use of scoring systems in intensive care. Acta Medica Lituanica, 10, 62−64.
 
Karjagin, J.; Pähkla, R.; Starkopf, J. (2004). Metronidasooli kontsentratsioon septilises šokis olevate patsientide vereplasmas ja lihaskoes. Eesti Arst, 83 (2), 87−92.
 
Reintam, A.; O'Konnel, N.; Jekimov, H.; Starkopf, J. (2004). Tsentraalvenoosse rõhu interpretatsioon sepsisega intensiivravihaigetel. Eesti Arst, 83 (3), 168−172.
 
Tähepõld, P.; Ruusalepp, A.; Zilmer, M.; Valen, G.; Vaage, J.; Starkopf, J. (2003). Hüperoksia - kas uus võimalus südamelihase kaitseks? Eesti Arst, 1, 22-28.
2.2. Monograafiad (sisestatud enne 1. juulit 2014. a.)
 
Soomets, U; Starkopf, J; Zilmer, Mihkel; Karelson, Ello-Rahel; Vihalemm, Tiiu; Zilmer, K; Valkna, A; Sillard, R; Langel, Ü (1996). Bioorganic chemistry for medical students. Tartu: Tartu University.
2.3. Dissertatsioonide seerias ilmunud dissertatsioonid (v.a. käsikirjalised);
 
Starkopf, J. (1997). Oxidative stress and ischaemia-reperfusion of the heart. A clinical and experimental study. (Doktoritöö, University of Tartu, University of Tromso). Tartu: Tartu University Press.
3.1. Artiklid/peatükid lisas loetletud kirjastuste välja antud kogumikes (kaasa arvatud Web of Science Book Citation Index, Web of Science Conference Proceedings Citation Index, Scopus refereeritud kogumikud)
 
Valen, G.; Tähepôld, P.; Starkopf, J.; Ruusalepp, A.; Vaage, J. (2003). Adaptation to ischemia by hyperoxia-signalling through mitogen activated protein kinases and nuclear factor kappa B. In: Dhalla, N.; Hryshko, L.; Kardami, E.; Singal, P.V. (Ed.). Signal transduction and cardiac hypertrophy (461−477). . Boston: Kluwer Academic Publishers.
 
Kokk, K.; Starkopf, J.; Sipria, A.; Zilmer, M.; Talvik, R. (1995). Compared evidence of oxidative stress in SIRS and cardiac surgery patients. Proceedings of 8th European Congress of Intensive Care Medicine, Athens: 8th European Congress of Intensive Care Medicine, Athens, 1995. , 69−73.
5.2. Konverentsiteesid, mis ei kuulu valdkonda 5.1
 
Eltermaa, Mall; Jakobson, Maili; Utt, Meeme; Kõks, Sulev; Mägi, Reedik; Starkopf, Joel (2019). Geneetilistel variantidel humaniini nukleaarsete isovormide geenides ei ole statistiliselt olulist seost koronaararteri haigusega. Eesti Arst, 98. OÜ Celsius Healthcare, 36−36.
6.2. Õpikud ja muud õppeotstarbelised publikatsioonid, v.a. kõrgkooliõpikud;
 
Starkopf, J.; Jekimov, H.; Karjagin, J.; Reinhard, V.; Saar, T.; Sõrmus, A.; Tamme, K.; Tähepõld, P. (2008). Valitud peatükke anestesioloogiast ja intensiivravist I. . Tartu Ülikooli Kirjastus.
 
Soomets, U.; Zilmer, M.; Starkopf, J.; Karelson, E.-R.; Vihalemm, T.; Zilmer, K.; Sillard, R.; Bourne, J; Langel, Ü. (1999). Selected knowledge for medical biochemistry. Tartu: Tartu Ülikooli Kirjastus.
9.07.2021

Otsi projekti

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Uus Frascati (2015)
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ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
1.1.5.2.SARAI120119T (3.2.1001.11-0032)Antibiootikumide doseerimine raskete infektsioonide korral01.01.201231.08.2015Joel StarkopfTartu Ülikool; Tartu Ülikool, Arstiteaduskond434 558,70 EUR
SFSF_0182548As03Endoteeli düsfunktsionaalsuse ja neurodegeneratsiooni oksüdatiivse stressi põhine mudel01.01.200331.12.2007Mihkel ZilmerTartu Ülikool, Arstiteaduskond0,00 EUR
SFSF0182548As03Endoteeli düsfunktsionaalsuse ja neurodegeneratsiooni oksüdatiivse stressi põhine mudel01.01.200331.12.2007Mihkel ZilmerTartu Ülikool, Arstiteaduskond433 704,46 EUR
ETFETF6950Gastrointestinaalne puudulikkus ja intra-abdominaalne hüpertensioon intensiivravi haigetel01.01.200731.12.2009Joel StarkopfTartu Ülikool, Arstiteaduskond51 078,20 EUR
PUT; PUT_OPPUT1160Humaniinid - uued võimalused kardiovaskulaarsüsteemi haiguste ravis01.01.201631.12.2019Joel StarkopfTartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut196 754,40 EUR
ETFETF8227Hüperoksia poolt esilekutsutud eelkohastumuslik geeniekspressioon südamelihases ja põletikureaktsioon koronaaroperatsioonidel01.01.201031.12.2013Inga KaruTartu Ülikool, Arstiteaduskond47 927,90 EUR
ETFETF7080Hüperoksiline eelkohastumus ja südamelihase isheemia-reperfusiooni kahjustus – kliiniline uuring01.01.200731.12.2009Peeter TähepõldTartu Ülikool, Arstiteaduskond44 040,75 EUR
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