Career

Institution and occupation

01.01.2007–... TUIT professor of Biomedicinetechnology

1992–... Department of Microbiology and Virology, Tartu University, Professor (1,00)

1986–... Estonian Biocentre, Head of the Laboratory of Oncogenesis (1,00)

2008–2015 Icosagen AS, Chief Executive Officer (1,00)

2007–2012 University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Professor (1,00)

01.09.2002–31.08.2007 University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Director (1,00)

01.02.2002–31.01.2007 University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Professor (1,00)

01.01.2002–31.12.2007 Director of Tartu University Institute of Technology

2001–2001 Estonian Science Academy, Academician (1,00)

2000–2011 FIT Biotech Oyj Plc, Chief Scientific Officer (1,00)

1996–1999 Tartu University Institute of Molecular and Cell Biology, Head of the Tartu University Institute of Molecular and Cell Biology (1,00)

1989–1992 Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, Visiting scientist (1,00)

1985–1989 Laboratory of Oncogenesis, Tartu University, Head of the Laboratory of Oncogenesis, Tartu University (1,00)

1984–1984 University of Tartu, Senior Researcher (1,00)

1982–1985 Uppsala Ülikooli Meditsiinilise Geneetika Instituut, Post-doctoral training (1,00)

1979–1985 University of Tartu, Senior Researcher (1,00)

1976–1982 University of Tartu, 1976-1982, Senior Ingenieur, Junior Researcher, Senior Researcher (1,00)

1976–1979 University of Tartu, Junior Researcher (1,00)

1975–1976 Inst. of Cybernetics Estonian Academy of Sciences, Junior Scientist (1,00)

1974–1975 Institute of Cybernetics, Senior Ingenieur (1,00)

1972–1974 Army, Service (1,00)

1967–1972 TRÜ Füüsika-keemia teaduskond, keemiaosakonna üliõpilane (1,00)

R&D related managerial and administrative work

Chairman of the Chemistry and Molecular Biology subcommittee of the Estonian Science Foundation

Member of Council, Tartu University's Institute of Molecular and Cell Biology

Member of Council, Tartu University's Faculty of Biology and Geography

Member of Council of the Estonian Biocentre

Member of Council of Tartu University's Centre of Strategical Competence

Member of expert committe of the Finnish Academy of Sciences and the chairman of an expert committee

Publications

Category

Year

Publication

1.1.

2017

Henno, Liisi; Tombak, Eva-Maria, Geimanen Jelizaveta; Orav, Marit; Ustav, Ene; Ustav, Mart. (2017). Analysis of human papillomavirus genome replication using two- and three-dimensional agarose gel-electrophoresis. Current Protocols in Microbiology, x−xx [ilmumas].

1.1.

2017

Toots, Mart; Ustav, Mart Jr.; Männik, Andres; Mumm, Karl; Tämm, Kaido; Tamm, Tarmo; Ustav, Ene; Ustav, Mart. (2017). Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay. PLoS Pathogens, 1−27.10.1371/journal.ppat.1006168 [ilmumas].

1.1.

2016

Kurg, Reet; Reinsalu, Olavi; Jagur, Sergei; Õunap, Kadri; Võsa, Liisi; Kasvandik, Sergo; Padari, Kärt; Gildemann, Kiira; Ustav, Mart (2016). Biochemical and proteomic characterization of retrovirus Gag based microparticles carrying melanoma antigens. Scientific Reports, 6 (29245), 1−11.10.1038/srep29425.

1.1.

2016

Kivi, Gaily; Teesalu, Kaupo; Parik, Jüri; Kontkar, Elen; Ustav, Mart; Noodla, Liis; Ustav, Mart; Männik, Andres (2016). HybriFree: a robust and rapid method for the development of monoclonal antibodies from different host species. BMC biotechnology, 16 (1), 2−2, 10.1186/s12896-016-0232-6.

1.1.

2015

Reinson, Tormi; Toots, Mart; Ustav, Mart Jr;Ustav, Mart. (2015). The Cell Cycle Timing of Human Papillomavirus DNA Replication. PLoS ONE, 10 (7), 1−16, 10.1371/journal.pone.0131675.

1.1.

2015

Ustav, Mart Jr; Castaneda, Fernando-Rodriguez; Reinson, Tormi; Männik, Andres; Ustav, Mart (2015). Human Papillomavirus Type 18 cis-Elements Crucial for Segregation and Latency. PLoS ONE, 10 (8), 1−24.10.1371/journal.pone0135770.eCollection2015.

1.1.

2015

Kivipõld, P.; Võsa, L.; Ustav, M.; Kurg, R. (2015). DAXX modulates human papillomavirus early gene expression and genome replication in U2OS cells. Virology Journal, 12, 104, 10.1186/s12985-015-0335-z.

1.1.

2015

Sankovski, Eve; Karro, Kristiina; Sepp, Mari; Kurg, Reet; Ustav, Mart; Abroi, Aare (2015). Characterization of the nuclear matrix targeting sequence (NMTS) of the BPV1 E8/E2 protein - the shortest known NMTS. Nucleus, 289−300.10.1080/19491034.2015.1074359.

1.1.

2015

Isok-Paas, Helen; Männik, Andres; Ustav, Ene; Ustav, Mart. (2015). The transcription map of HPV11 in U2OS cells adequately reflects the initial and stable replication phases of the viral genome. Virology Journal, 1−15.

3.1.

2015

Karro, Kristiina; Männik, Tiiu; Männik, Andres; Ustav, Mart (2015). DNA Transfer into Animal Cells Using Stearylated CPP Based Transfection Reagent. In: Ülo Langel (Ed.). Cell-Penetrating Peptides (435−445). New York: Springer. (Methods in Molecular Biology; 1324).

1.1.

2014

Toots, Mart; Männik, Andres; Kivi, Gaili; Ustav, Mart JR.; Ustav, Ene; Ustav, Mart (2014). The Transcription Map of Human Papillomavirus Type 18 during Genome Replication in U2OS Cells. PLoS ONE, 9 (12), 1−31.

1.1.

2014

Sankovski, Eve; Männik, Andres; Geimanen, Jelizaveta; Ustav, Ene; Ustav, Mart (2014). Mapping of Beta-Papillomavirus HPV5 Transcription and Characterization of Viral Genome Replication Function. Journal of Virology, 88 (2), 961−973.

6.6.

2014

Ustav, Mart; Soomere, Tarmo (2014). Eesti Teaduste Akadeemia presidendiks kandideerivad Mart Ustav ja Tarmo Soomere / Margus Maidla, intervjueerija. Sirp : Eesti kultuurileht, 35−37.

1.1.

2013

Toots, Mart; Männik, Andres; Kivi, Gaily; Ustav Jr., Mart; Ustav, Ene; Ustav, Mart (2013). http://www.ncbi.nlm.nih.gov/pubmed/25548925. PLoS ONE, 9 (12), 1−31, 10.1371/journal.pone.0116151.

1.1.

2013

Orav, Marit; Henno, Liisi; Isok-Paas, Helen; Geimanen, Jelizaveta; Ustav, Mart; Ustav, Ene (2013). Recombination-Dependent Oligomerization of Human Papillomavirus Genomes upon Transient DNA Replication. Journal of Virology, 87 (22), 12051−12068.10.1128/JVI.01798-13.

1.1.

2013

Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PloS Pathogens, 9 (9), e1003610.10.1371/journal.ppat.1003610.

1.1.

2013

Arukuusk, P.; Pärnaste, L.; Oskolkov, N.; Copolovici, D. M.; Margus, H.; Padari, K.; Möll, K.; Maslovskaja, J.; Tegova, R.; Kivi, G.; Tover, A.; Pooga, M.; Ustav, M.; Langel, Ü. (2013). New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. Biochimica et Biophysica Acta-Biomembranes, 1828 (5), 1365−1373.10.1016/j.bbamem.2013.01.011.

1.1.

2013

Reinson, Tormi; Toots, Mart; Kadaja, Meelis; Pipitch, Regina; Allik, Mihkel; Ustav, Ene; Ustav, Mart (2013). Engagement of the ATR-Dependent DNA Damage Response at the Human Papillomavirus 18 Replication Centers during the Initial Amplification. Journal of Virology, 87 (2), 951−964.10.1128/JVI.01943-12.

1.1.

2012

Võsa, L; Sudakov, A; Remm, M; Ustav, M; Kurg, R. (2012). Identification and analysis of papillomavirus E2 protein binding sites in the human genome. Journal of Virology, 86 (1), 348−357, 10.1128/JVI.05606-11.

1.1.

2012

Vardas, E.; Stanescu, I.; Leinonen, M.; Ellefsen, K.; Pantaleo, G.; Valtavaara, M.; Ustav, M.; Reijonen, K. (2012). Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU(®)-Multi-HIVB, in untreated HIV-1 infected subjects. Vaccine, 8, 4046−4054, 10.1016/j.vaccine.2012.04.007.

1.1.

2011

Geimanen, J.; Isok-Paas, H.; Pipitch, R.; Salk, K.; Laos, T.; Orav, M.; Reinson, T.; Ustav, M. Jr.; Ustav, M.; Ustav, E. (2011). Development of a cellular assay system to study the genome replication of high- and low-risk mucosal and cutaneous human papillomaviruses. Journal of Virology, 85 (7), 3315−3329.

1.1.

2010

Kurg, R; Uusen, P; Võsa, L; Ustav, M (2010). Human papillomavirus E2 protein with single activation domain initiates HPV18 genome replication, but is not sufficient for long-term maintenance of virus genome. Virology, 408 (2), 159−166, 10.1016/j.virol.2010.09.010.

1.1.

2010

Silla, Toomas; Männik, Andres; Ustav, Mart (2010). Effective Formation of the Segregation-competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome During Cell Division. Journal of Virology, 84 (21), 11175−11188, 10.1128/JVI.01366-10.

1.1.

2009

Martinon, F.; Kaldma, K.; Sikut, R.; Culina, S.; Romain, G.; Tuomela, M.; Adojaan, M.; Männik, A.; Toots, U.; Kivisild, T.; Morin, J.; Brochard, P.; Delache, B.; Tripiciano, A.; Ensoli, F.; Stanescu, I.; Le Grand, R.; Ustav, M. (2009). Persistent Immune Responses Induced by a Human Immunodeficiency Virus DNA Vaccine Delivered in Association with Electroporation in the Skin of Nonhuman Primates. Human Gene Therapy, 20 (11), 1291−1307, 10.1089/hum.2009.044.

1.1.

2009

Kadaja, M.; Isok-Paas, H.; Laos, T.; Ustav, E.; Ustav, M. (2009). Mechanism of Genomic Instability in Cells Infected with the High-Risk Human Papillomaviruses. PloS Pathogens, e1000397−e1000397, 10.1371/journal.ppat.1000397.

1.1.

2009

Kadaja, M; Silla, T; Ustav, E; Ustav, M. (2009). Papillomavirus DNA replication - from initiation to genomic instability. Virology, 384 (2), 360−368, 10.1016/j.virol.2008.11.032.

1.1.

2009

Kurg, R.; Uusen, P.; Sepp, T.; Sepp, M.; Abroi, A.; Ustav, M. (2009). Bovine papillomavirus type 1 E2 protein heterodimer is functional in papillomavirus DNA replication in vivo. Virology, 386 (2), 353−359.10.1016/j.virol.2009.01.025.

1.1.

2008

Nikonov, A.; Juronen, E.; Ustav, M. (2008). Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase. Journal of Biological Chemistry, 283 (35), 24089−24102, 10.1074/jbc.M803422200.

1.1.

2007

Rausalu, K.; Karo-Astover, L.; Kilk, A.; Ustav, M. (2007). CuZn-SOD suppresses the Bovine Papillomavirus-induced proliferation of fibroblasts. APMIS, 115 (12), 1415−1421, 10.1111/j.1600-0463.2007.00779.x.

1.1.

2007

Kadaja, M.; Sumerina, A.; Verst, T.; Ojarand, M.; Ustav, E.; Ustav, M. (2007). Genomic instability of the host cell induced by the human papillomavirus replication machinery. EMBO Journal, 26 (8), 2180−2191.

1.1.

2007

Adojaan, M.; Mölder, T.; Männik, A.; Kivisild, T.; Villems, R.; Krispin, T.; Ustav, M. (2007). High prevalence of the CCR5delta32 HIV-resistance mutation among Estonian HIV-1-infected individuals. Aids Research and Human Retroviruses, 23 (2), 193−197, 10.1089/aid.2006.0113.

1.1.

2006

Kiiver, K.; Merits, A.; Ustav, M.; Žusinaite, E. (2006). Complex formation between hepatitis C virus NS2 and NS3 proteins. Virus Research, 117 (2), 264−272.

1.1.

2006

Ilves, I.; Mäemets, K.; Silla, T.; Janikson, K.; Ustav, M. (2006). Brd4 is involved in multiple processes of bovine papillomavirus BPV1 life cycle. Journal of Virology, 80 (7), 3660−3665.

1.1.

2006

Kilk, A.; Rausalu, K.; Ustav, M. (2006). Bovine papillornavirus type 1 oncoprotein E5 stimulates the utilization of superoxide radicals in the mouse fibroblast cell line C127. Chemico-Biological Interactions, 159 (3), 205−212.

1.1.

2005

Kurg, R.; Sild, K.; Ilves, A.; Sepp, M.; Ustav, M. (2005). Association of bovine papillomavirus E2 protein with nuclear structures in vivo. Journal of Virology, 79 (16), 10528−10539.

1.1.

2005

Silla, T.; Haal, I.; Geimanen, J.; Janikson, K.; Abroi, A.; Ustav, E.; Ustav, M. (2005). Episomal maintenance of plasmids with hybrid origins in mouse cells. Journal of Virology, 79 (24), 15277−15288.

1.1.

2004

Abroi, A.; Kivi, S.; Ves, I. ; Ustav, M. (2004). Analysis of chromatin attachment and partitioning functions of bovine papillomavirus type 1 E2 protein. Journal of Virology, 78 (4), 2100−2113.

1.1.

2003

Ilves, I.; Kadaja, M.; Ustav, M. (2003). Two separate replication modes of the bovine papillomavirus BPV1 origin of replication that have different sensitivity to p53. Virus Research, 96, 75−84.

1.1.

2003

Mannik, A.; Piirsoo, M.; Nordstrom, K.; Ustav, E.; Vennstrom, B.; Ustav, M. (2003). Effective generation of transgenic mice by Bovine papillomavirus type 1 based self-replicating plasmid that is maintained as extrachromosomal genetic element in three generations of animals. Plasmid, 49 (3), 193−204.

1.1.

2003

Jaanson, N.; Moll, K.; Kulla, A.; Ustav, M. (2003). Identification of the immunodominant regions of the melanoma antigen tyrosinase by anti-tyrosinase monoclonal antibodies. Melanoma Research, 13 (5), 473−482.

1.1.

2002

Andreson, H.; Loivukene, K.; Sillakivi, T.; Maaroos, HI.; Ustav, M.; Peetsalu, A.; Mikelsaar, M. (2002). Association of cagA and vacA genotypes of Helicobacter pylori with gastric diseases in Estonia. Journal of Clinical Microbiology, 40 (1), 298−300.

1.1.

2002

Mannik, A.; Runkorg, K.; Jaanson, N.; Ustav, M.; Ustav, E. (2002). Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo. Journal of Virology, 76 (11), 5835−5845.

1.1.

2002

Tammur, J.; Sibul, H.; Ustav, E.; Ustav, M.; Metspalu, A. (2002). A bovine papillomavirus-I based vector restores the function of the low-density lipoprotein receptor in the receptor-deficient CHO-ldlA7 cell line (vol 3, art no 5, 2002). BMC Molecular Biology, 3, -.

1.1.

2002

Tammur, J.; Sibul, H.; Ustav, E.; Ustav, M.; Metspalu, A. (2002). A bovine papillomavirus-1 based vector restores the function of the low-density lipoprotein receptor in the receptor-deficient CHO-ldlA7 cell line. BMC Molecular Biology, 3, -.

1.1.

2001

Tähtinen, M.; Strengell, M.; Collings, A.; Pitkänen, J.; Hakkarainen, K.; Ustav, M.; Wahren, B.; Peterson, P.; Kohleisen, B.; Ranki, A.; Krohn, K. (2001). DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating bovine papilloma virus based pBN-vector. Vaccine, 19, 2039−2047.

1.1.

2001

Kivimae, S.; Allikas, A.; Kurg, R.; Ustav, M. (2001). Replication of a chimeric origin containing elements from Epstein-Barr virus ori P and bovine papillomavirus minimal origin. Virus Research, 75 (1), 1−11.

1.1.

2001

Sillakivi, T.; Aro, H.; Ustav, M.; Peetsalu, M.; Peetsalu, A.; Mikelsaar, M. (2001). Diversity of Helicobacter pylori genotypes among Estonian and Russian patients with perforated peptic ulcer, living in Southern Estonia. FEMS Microbiology Letters, 195 (1), 29−33.

1.1.

2001

Allikas, A.; Ord, D.; Kurg, R.; Kivi, S.; Ustav, M. (2001). Roles of the hinge region and the DNA binding domain of the bovine papillomavirus type 1 E2 protein in initiation of DNA replication. Virus Research, 75 (2), 95−106.

1.1.

2001

Lampela, P.; Ustav, E.; Ustav, M.; Niskanen, M.; Mannisto, PT.; Raasmaja, A. (2001). Efficient transfection of novel bovine papillomavirus 1 expression plasmids. Plasmid, 46 (3), 163−169.

1.1.

2001

Vali, U.; Kilk, A.; Ustav, M. (2001). Bovine papillomavirus oncoprotein E5 affects the arachidonic acid metabolism in cells. International Journal of Biochemistry & Cell Biology, 33 (3), 227−235.

1.1.

2001

Koljak, R.; Jarving, I.; Kurg, R.; Boeglin, WE.; Varvas, K.; Valmsen, K.; Ustav, M.; Brash, AR.; Samel, N. (2001). The basis of prostaglandin synthesis in coral - Molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. Journal of Biological Chemistry, 276 (10), 7033−7040.

1.2.

2001

Raasmaja, A.; Soosaar, A.; Lampela, P.; Kõks, S.; Männik, A.; Volke, V.; Huotari, M.; Joki, S.; Ustav, E.; Vasar, E.; Ustav, M.; Männistö, P. (2001). Tyrosine Hydroxylase gene Transfer to Rat Striatum Using Bovine Papilloma Virus-1 Expression Plasmids in the Experimental Model of Parkinson's Disease. In: Pharmaceutical and Pharmacological Letters (83−86). (2).

1.1.

2000

Zusinaite, E.; Krispin, T.; Raukas, E.; Kiiver, K.; Salupere, R.; Ott, K.; Ustina, V.; Zilmer, K.; Schmidt, J.; Sizemski, L.; Jaago, K.; Luman, M.; Ilmoja, M.; Prukk, T.; Ustav, M. (2000). Hepatitis C virus genotypes in Estonia. APMIS, 108 (11), 739−746.

1.1.

2000

Kaldalu, N.; Toots, U.; de Lorenzo, V.; Ustav, M. (2000). Functional domains of the TOL plasmid transcription factor XylS. Journal of Bacteriology, 182 (4), 1118−1126.

1.1.

2000

Lepik, D.; Ustav, M. (2000). Cell-specific modulation of papovavirus replication by tumor suppressor protein p53. Journal of Virology, 74 (10), 4688−4697.

1.1.

2000

Loivukene, K.; Kolk, H.; Maaroos, HI.; Kasenomm, P.; Aro, H.; Ustav, M.; Mikelsaar, M. (2000). Metronidazole and clarithromycin susceptibility and the subtypes of VacA of Helicobacter pylori isolates in Estonia. Scandinavian Journal of Infectious Diseases, 32 (1), 59−62.

1.1.

2000

Kaldalu, N.; Lepik, D.; Kristjuhan, A.; Ustav, M. (2000). A Novel Immunotag System for Monitoring and Purification of Proteins. Biotechniques, 28 (3), 456−462.

3.2.

2000

Kurg, R; Ustav, M. (2000). Update to: Monitoring and Purification of Proteins Using Bovine Papillomavirus E2 Epitope Tags. Lu,Q.; M.P. Weiner. Cloning and Expression Vectors for Protein Studies (Chapter 27). Weiner: Eaton Publishing Co.

5.2.

2000

Zusinaite, E.; Krispin, T.; Raukas, E.; Kiiver, K.; Salupere, R.; Ott, K.; Ustina, V.; Zilmer, K.; Schmidt, J.; Zisemski, L.; Jaago, K.; Luman, M.; Ilmoja, M.; Prükk, T.; Ustav, M. (2000). Hepatitis C virus genotypes in Estonia. 4th Nordic-Baltic Congress on Infectious Diseases "Prudent use of antibiotics", 17.05.-19.05.2005, Tallinn. Tallinn: Oriola, 50.

1.1.

1999

Koljalc, S.; Sults, I.; Raukas, E.; Truu, J.; Ustav, M.; Mikelsaar, M. (1999). Distribution of Acinetobacter baumannii in a neurointensive care unit. Scandinavian Journal of Infectious Diseases, 31 (2), 145−150.

1.1.

1999

Collings, A.; Pitkanen, J.; Strengell, M.; Tahtinen, M.; Pitkanen, J.; Lagerstedt, A.; Hakkarainen, K.; Ovod, V.; Sutter, G.; Ustav, M.; Ustav, E.; Mannik, A; Ranki, A; Peterson, P.; Krohn, K. (1999). Humoral and cellular response to HIV-1 Nef in mice DNA-immunized with non-replicating and self-replicating expression vectors. Vaccine, 18, 460−467.

1.1.

1999

Prükk, T.; Raukas, E.; Martin, M.; Ustav, M. (1999). Prevalence of Ticks Infected with Borrelia burgdorferi in Estonia. Zentralblatt für Bakteriologie-International Journal of Medical Microbiology Virology Parasitology and Infectious Diseases, 289, 706−710.

1.1.

1999

Remm, M.; Remm, A.; Ustav, M. (1999). Human papillomavirus type 18 E1 protein is translated from polycistronic mRNA by a discontinuous scanning mechanism. Journal of Virology, 73 (4), 3062−3070.

1.1.

1999

Ilves, I.; Kivi, S.; Ustav, M. (1999). Long-term episomal maintenance of bovine papillomavirus type 1 plasmids is determined by attachment to host chromosomes, which is mediated by the viral E2 protein and its binding sites. Journal of Virology, 73 (5), 4404−4412.

5.1.

1999

Loivukene, K.; Kolk, H.; Mikelsaar, M.; Kasenomm, P.; Ustav, M.; Maaroos, HI. (1999). Comparison of metronidazole susceptibility and vacA subtypes of H-pylori strains in patients with gastritis and peptic ulcer. GUT, 45, A14−A14.

5.1.

1999

Kivi, S.; Ilves, I.; Ustav, M. (1999). Association of bovine papillomavirus type 1 plasmids to host chromosomes and their long-term episomal maintenance is mediated by the viral E2 protein and its binding sites. Cytogenetics and Cell Genetics, 85, 113−113.

5.1.

1999

Ustav, E.; Mannik, A.; Mandel, T.; Runkorg, K.; Piirsoo, M.; Nordstrom, K.; Vennstrom, B.; Ustav, M. (1999). Generation and analysis of the BPV-1 based vector system for gene therapy. Human Gene Therapy, 10 (5), 852−852.

1.1.

1998

Koks, S.; Soosaar, A.; Voikar, V.; Volke, V.; Ustav, M.; Mannisto, PT.; Bourin, M.; Vasar, E. (1998). Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze. Neuropeptides, 32 (3), 235−240.

1.1.

1998

Lepik, D.; Ilves, I.; Kristjuhan, A.; Maimets, T.; Ustav, M. (1998). p53 protein is a suppressor of papillomavirus DNA amplificational replication. Journal of Virology, 72 (8), 6822−6831.

1.2.

1998

Ustav, E.; Ustav, M. (1998). E2 protein as the master regulator of extrachromosomal replication of the papillomaviruses. Papillomavirus Report, 9, 145−152.

1.1.

1996

Piirsoo, M.; Ustav, E.; Mandel, T.; Stenlund, A.; Ustav, M. (1996). Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator. EMBO Journal, 15 (1), 1−11.

1.1.

1996

Kaldalu, N.; Mandel, T.; Ustav, M. (1996). TOL plasmid transcription factor XylS binds specifically to the Pm operator sequence. Molecular Microbiology, 20 (3), 569−579.

1.1.

1996

Kilk, A.; Talpsepp, T.; Vali, U.; Ustav, M. (1996). Bovine papillomavirus oncoprotein E5 induces the NF kappa B activation through superoxide radicals. Biochemistry and Molecular Biology International, 40 (4), 689−697.

1.1.

1996

Abroi, A.; Kurg, R.; Ustav, M. (1996). Transcriptional and replicational activation functions in the bovine papillomavirus type 1 E2 protein are encoded by different structural determinants. Journal of Virology, 70 (9), 6169−6179.

5.1.

1995

Ustav, M.; Talpsepp, T.; Kilk, A.; Väli, Ü.; Burnett, S. (1995). Overexpression of the BPV-1 E5 oncoprotein induces an apoptosis. Abstracts of papers presented at the Imperail Cancer Research Fund Tumour Virus Meeting on PapovavirusesPapillomaviruses and Adenoviruses 17-22 July, 1995, Churchill College: Tumour Virus Meeting on Papovaviruses Papillomaviruses and Adenoviruses; Churchill College; 17-22 July, 1995. Cambridge, England, 137.

1.1.

1994

Aleshkov, SB.; Ustav, MB.; Baev, AA. (1994). Recombinant mouse-cell lines transformed with different type-1 bovine papilloma virus-based vectors and expressing human tissue-plasminogen activator. 1. Analysis of cell-lines producing recombinant tissue-plasminogen activator. Molecular Biology, 28 (3), 411−414.

5.1.

1994

Sedman, J.; Ustav, M.; Stenlund, A. (1994). Dna-replication of papillomaviruses. Journal of Cellular Biochemistry, 211−211.

1.1.

1993

Ustav, E.; Ustav, M.; Szymanski, P.; Stenlund, A. (1993). The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator. Proceedings of the National Academy of Sciences of the United States of America, 90 (3), 898−902.

5.2.

1993

Talpsepp, T.; Kilk, A.; Ustav, M.; Zilmer, M. (1993). The bovine papilloma virus encoded E5 oncoprotein action mechanism in cell transformation. Microbiological research in Estonia: information on research projects . Tartu: Estonian Society for Microbiology, 8.

1.1.

1991

Aleshkov, SB.; Ustav, MB.; Bayev, AA. (1991). Comparison of usual and modified bpv-based vector properties. Doklady Akademii Nauk SSSR, 318 (6), 1472−1475.

1.1.

1991

Aleshkov, SB.; Ustav, MB.; Baev, AA. (1991). Expression of human tissue plasminogen-activator by recombinant cell-lines of various animals. Molecular Biology, 25 (5), 960−970.

1.1.

1991

Aleshkov, SB.; Ustav, MB.; Baev, AA. (1991). Recombinant mouse-cell lines transformed by various vectors based on bovine type-1 papillomavirus and expressing human tissue plasminogen-activator. Molecular Biology, 25 (5), 971−977.

1.2.

1991

Ustav, M.; Ustav, E.; Szymanski, P.; Stenlund, A. (1991). Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1. EMBO Journal, 10 (13), 4321−4329.

1.1.

1989

Aleshkov, SB.; Ustav, MB.; Baev, AA. (1989). Expression of human tpa cdna in human-cells under different eukaryotic promoters. Doklady Akademii Nauk SSSR, 309 (3), 721.

1.1.

1988

Bergman, P.; Ustav, M.; Sedman, J.; Morenolopez, J.; Vennstrom, B.; Pettersson, U. (1988). The e5 gene of bovine papillomavirus type-1 is sufficient for complete oncogenic transformation of mouse fibroblasts. Oncogene, 2 (5), 453−459.

1.1.

1984

Maimets, T. O.; Ustav, M. B.; Remme, J. L.; Villems, R. L.-E. (1984). The L16 protein of the escherichia-coli ribosome: its possible role in protein biosynthesis. Molecular Biology, 18 (6), 1305−1313.

1.1.

1984

Maimets, TO.; Ustav, MB.; Remme, YL.; Villems, RlE. (1984). The l16 protein of the escherichia-coli ribosome - possible role in protein-biosynthesis. Molecular Biology, 18 (6), 1305−1313.

1.1.

1983

Metspalu, E.; Ustav, M.; Villems, R. (1983). 5-S RNA protein complex is involved in ribosomal-subunit association. FEBS Letters, 153 (1), 125−127.

1.1.

1983

Remme, J.; Maimets, T.; Ustav, M.; Villems, R. (1983). The interaction of ribosomal protein-l16 and its fragments with transfer-rna. FEBS Letters, 153 (2), 267−269.

1.1.

1983

Maimets, T.; Ustav, M.; Villems, R. (1983). The role of protein-l16 and its fragments in the peptidyltransferase activity of 50-s ribosomal-subunits. European Journal of Biochemistry, 135 (1), 127−130.

1.1.

1982

Metspalu, E.; Ustav, M.; Maimets, T.; Villems, R. (1982). The composition and properties of the escherichia-coli 5-s RNA- protein complex. European Journal of Biochemistry, 121 (2), 383−389.

1.1.

1982

Matspalu, E.; Ustav, M.; Villems, R. (1982). The properties of the transfer-RNA. Protein complex of the escherichia-coli ribosome interaction with transfer-rna, 5-s RNA and 30-s ribosomal-subunit. European Journal of Biochemistry, 124 (2), 269−273.

1.1.

1981

Maimets, T. O.; Ustav, M. B.; Villems, R. L.-E.; Saarma, M. J.; Lind, A. J. (1981). Binding of proteins of the Escherichia coli 50 S ribosomal subparticle to two large fragments of 5S RNA. Molecular Biology, 15 (3), 440−445.

1.1.

1981

Metspalu, E.; Maimets, T.; Ustav, M.; Villems, R. (1981). A quaternary complex consisting of 2 molecules of transfer-RNA and ribosomal-proteins L2 and L17. FEBS Letters, 132 (1), 105−108.

1.1.

1981

Maimets, TO.; Ustav, MB.; Villems, RlE.; Saarma, MY.; Lind, AY. (1981). Binding of proteins of the escherichia-coli 50s ribosomal subparticle to 2 large fragments of 5s-rna. Molecular Biology, 15 (3), 440−445.

1.1.

1981

Metspalu, EE.; Ustav, MB.; Villems, RlE. (1981). Complexes of immobilized transfer-RNA and 5s RNA with 50s ribosomal-subunit proteins bind 30s subunit of escherichia-coli ribosome. Bioorganicheskaya Khimiya, 7 (5), 784−786.

1.1.

1981

Sedman, J.; Maimets, T.; Ustav, M.; Villems, R. (1981). The interaction of 5-s-RNA and its large fragments with ribosomal-proteins. FEBS Letters, 136 (2), 251−254.

1.1.

1980

Speek, M.; Ustav, M.; Lind, A.; Saarma, M. (1980). Characterization of the secondary structure of the Escherichia coli 5S RNA using S1 nuclease and cobra venom endonuclease. Bioorganicheskaya Khimiya, 6 (12), 1877−1880.

1.1.

1980

Speek, MA.; Ustav, MB.; Lind, AJ.; Saarma, MJ. (1980). Structural studies of escherichia-coli 5s RNA with s1 nuclease and endonuclease from cobra venom. Bioorganicheskaya Khimiya, 6 (12), 1877−1880.

3.1.

1980

Villems, R.; Koger, A.; Lind, A.; Maimets, T.; Metspalu, E.; Saarma, M.; Sarapuu, T.; Ustav, M. (1980). Affinity chromatography of Escherichia coli ribosomal protein on the immobilized ribonucleic acids. Properties of the complexes. In: Augustyniak, J. (Ed.). Biological implications of protein-nucleic acid interactions (91−99). Amsterdam: Elsevier.

1.1.

1979

Kesvatera, T.; Ustav, M.; Aaviksaar, A. (1979). Cobra venom acetylcholinesterase. 2. Substrate-specificity. Comparative Biochemistry and Physiology C-Pharmacology Toxicology & Endocrinology, 62 (2), 193−197.

1.1.

1979

Ustav, MB.; Remme, JL.; Lind, AJ.; Villems, RlE. (1979). New efficient route to immobilization of ribonucleic-acids and nucleotides on agarose. Bioorganicheskaya Khimiya, 5 (3), 365−369.

1.2.

1979

Saarma, M.; Villems, R.; Laving, A.; Metspalu, A.; Toots, I.; Ustav, M.; Lind, A. (1979). On the origin of eukaryotic 5.8S RNA. Hoppe-Seylers Zeitschrift für Physiologische Chemie, 360, 1040−1041.

1.1.

1978

Ustav, M.; Saarma, M.; Lind, A.; Villems, R. (1978). Domain for transfer ribonucleic-acid binding to escherichia-coli ribosome. FEBS Letters, 87 (2), 315−317.

1.1.

1978

Metspalu, A.; Saarma, M.; Villems, R.; Ustav, M.; Lind, A. (1978). Interaction of 5-s RNA,5.8-s RNA and transfer-RNA with rat-liver ribosomal-proteins. European Journal of Biochemistry, 91 (1), 73−81.

1.1.

1977

Ustav, MB.; Lind, AJ.; Saarma, MJ.; Villems, RlE. (1977). Interaction of 5s RNA with escherichia-coli 30s ribosomal-subunit proteins. Bioorganicheskaya Khimiya, 3 (12), 1699−1701.

1.1.

1977

Ustav, M.; Villems, R.; Lind, A. (1977). Interaction of transfer ribonucleic-acid with 30 s ribosomal-subunit proteins. FEBS Letters, 82 (2), 259−262.

1.1.

1977

Ustav, M.; Villems, R.; Saarma, M.; Lind, A. (1977). Interaction of transfer ribonucleic-acid with 50-s ribosomal-subunit proteins. FEBS Letters, 83 (2), 353−356.

1.1.

1977

Lind, A.; Metspalu, A.; Saarma, M.; Toots, I.; Ustav, M.; Villems, R. (1977). Universal structure of peptidyl transferase center in ribosomes and function of eukaryotic 5.8s ribosomal ribonucleic-acid. Bioorganicheskaya Khimiya, 3 (8), 1138−1140.

1.2.

1977

Lind, A.; Metspalu, A.; Saarma, M.; Toots, I.; Ustav, M.; Villems, R. (1977). Universal structure of the ribosomal peptidyltransferase center and function of the eukaryotic 5,8S rRNA. Bioorganic Chemistry, 3, 1138−1140.

Programm	Number	Nimi	Projekti algus	Projekti lõpp	Vastutav täitja	Asutus	Rahastamine kokku

MUU	IARAR06122	Biomeditsiini ning molekulaar- ja rakubioloogia tuumiklaborite käivitamine	07.03.2006	30.06.2008	Mart Ustav	Tartu Ülikool	862 353,48 EUR
MUU	ISOCK06119	Biomeditsiini ning molekulaar- ja rakubioloogia tuumiklaborite käivitamine	07.03.2006	30.06.2008	Mart Ustav	Tartu Ülikool	424 526,73 EUR
MUU	IBGMR06120	Biomeditsiini ning molekulaar- ja rakubioloogia tuumiklaborite käivitamine	07.03.2006	30.06.2008	Mart Ustav	Tartu Ülikool	854 115,27 EUR
MUU	IP1TI06121	Biomeditsiini ning molekulaar- ja rakubioloogia tuumiklaborite käivitamine	07.03.2006	30.06.2008	Mart Ustav	Tartu Ülikool	1 556 229,47 EUR
MUU	SLOTI12206T (3.2.0701.12-0038)	Biotehnoloogiliste meetodite arendus toiduallergeenide seireks	01.12.2012	31.08.2015	Mart Ustav	Tartu Ülikool	530 136,63 EUR
MUU	MP1TI06246R	Development of multi-step improved epidermis-specific vaccine candidate against HIV1/AIDS	01.01.2007	31.12.2010	Mart Ustav	Tartu Ülikool	301 951,73 EUR
MUU	SLOTI11182T (3.2.0701.11-0016)	Hepatiit C viiruse vastaste ravimikandidaatide väljatöötamise platvorm	01.01.2012	31.12.2013	Andres Merits	Tartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond	872 230,20 EUR
MJD	MJD228	Identification of the mammalian chromatin host factor involved in the segregation of the human papillomavirus genome	10.02.2012	21.11.2014	Fernando Rodriguez-Castaneda	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	100 580,00 EUR
ETF	ETF9467	Inimese papilloomiviiruse genoomi segregatsiooni uurimine latentse nakkuse faasis	01.01.2012	31.12.2015	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	76 800,00 EUR
ETF	ETF7670	Inimese papilloomiviiruse genoomi stabiilse episomaalse säilumise mehhanismi väljaselgitamine ja ravimiarenduseks sobilike rakuliinide konstrueerimine	01.01.2008	31.12.2011	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond	73 885,16 EUR
ETF	ETF5998	Papilloomiviiruste genoomi mitootilise retseptori uurimine	01.01.2004	31.12.2007	Mart Ustav	Tartu Ülikool; Tartu Ülikool; Tartu Ülikool	51 040,75 EUR
MUU	ILOTI09106K	Rakupõhine skriinimismeetod HPV DNA replikatsiooni inhibiitorite leidmiseks (eeluuring)	01.06.2009	30.11.2009	Mart Ustav	Tartu Ülikool	18 965,65 EUR
SF	SF_0182566As03	RNA ja DNA genoomiga viiruste replikatsioonimehhanismide uurimine ja geeniteraapia ning geenvaktsineerimise uute meetodite väljatöötamine	01.01.2003	31.12.2007	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	0,00 EUR
SF	SF0182566As03	RNA ja DNA genoomiga viiruste replikatsioonimehhanismide uurimine ja geeniteraapia ning geenvaktsineerimise uute meetodite väljatöötamine A	01.01.2003	31.12.2007	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	267 534,17 EUR
SF	SF0182566Bs03	RNA ja DNA genoomiga viiruste replikatsioonimehhanismide uurimine ja geeniteraapia ning geenvaktsineerimise uute meetodite väljatöötamine B	01.01.2003	31.12.2007	Mart Ustav	Tartu Ülikool, Bioloogia-geograafiateaduskond	309 651,94 EUR
SF	SF0182566Cs03	RNA ja DNA genoomiga viiruste replikatsioonimehhanismide uurimine ja geeniteraapia ning geenvaktsineerimise uute meetodite väljatöötamine C	01.01.2003	31.12.2007	Mart Ustav	Eesti Biokeskus	259 673,02 EUR
SF	SF0180175s08	Signaaliülekande, apoptoosi, genoomi intaktsuse ja viirusvastaste aktiivsuste regulatsioon viirus-peremees interaktsioonide mõjul	01.01.2008	31.12.2013	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	0,00 EUR
SF	SF0180175As08	Signaaliülekande, apoptoosi, genoomi intaktsuse ja viirusvastaste aktiivsuste regulatsioon viirus-peremees interaktsioonide mõjul TÜTI	01.01.2008	31.12.2013	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	653 945,96 EUR
ETF	ETF5999	Terapeutiliste märklaudade identifitseerimise süsteemi konstrueerimine	01.01.2004	31.12.2007	Mart Ustav	Eesti Biokeskus	50 308,23 EUR
MUU	INTNL 55000339	The analysis of the mechanisms of extrachromosomal replication of the bovine papillomavirus genome	01.01.2001	31.12.2005	Mart Ustav	Eesti Biokeskus	238 869,79 EUR
MUU	ILOTI09107K	Uudne diagnostika ja prognostika meetod emakakaela vähieelsete seisundite tuvastamiseks (eeluuring)	01.06.2009	30.11.2009	Mart Ustav	Tartu Ülikool	18 684,38 EUR
MUU	SLOTI12105T	Uudne melanoomi patogeneesi immuunogeneetiline iseloomustamine	01.04.2012	15.09.2015	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	525 000,00 EUR
IUT	IUT20-27	Viiruse ja peremehe vaheliste interaktsioonide uurimine ja kasutamine biomeditsiinitehnoloogias	01.01.2014	31.12.2019	Andres Merits	Tartu Ülikool, Loodus- ja täppisteaduste valdkond, Tehnoloogiainstituut	1 560 800,00 EUR
AP	SF0180175As08AP12	Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180175As08 raames	01.01.2012	31.12.2012	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	57 950,00 EUR
AP	SF0180175As08AP	Väikesemahulise teaduse infrastruktuuri kaasajastamine teadusteema SF0180175As08 raames	01.01.2010	31.12.2011	Mart Ustav	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut	63 911,65 EUR

Pealkiri	Juhendatav	Kraad	Juhendaja	Kaitsmise staatus	Kaitsmise aasta	Asutus

Design and characterization of a novel vector system based on the stable replicator of bovine papillomavirus type 1	-	doktorikraad	Mart Ustav	Kaitstud	2003	Tartu Ülikool
Design, construction and production of cell penetrating recombinant proteins	-	doktorikraad	Ülo Langel; Mart Ustav; Andres Tover	Juhendamisel		Tartu Ülikool
DNA vaktsiinide erinevate manustamismeetodite ja geneetiliste adjuvantide toime uurimine immuunvastuse kujunemisele	-	doktorikraad	Mart Ustav; Rein Sikut	Juhendamisel		Tartu Ülikool
E2 as the modulator of the BPV1 DNA replication	-	doktorikraad	Mart Ustav	Kaitstud	1996	Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut
Episomaalsete DNA viiruste replikatsiooni- ja segregatsioonifunktsiooni uurimine	-	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	2004	Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut
Hepatiit C viiruse genotüpeerimine ja mittestruktuursete valkude omaduste uurimine	-	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	2001	Tartu Ülikool
Human papillomavirus type 18: replication, transformation and gene expression	-	doktorikraad	Mart Ustav	Kaitstud	1997	Tartu Ülikool
Inimese neutrofiilide tuumaantigeeni IGR-2 2F1 iseloomustamine.	-	magistrikraad	Sulev Ingerpuu; Mart Ustav	Kaitstud	2001	Tartu Ülikool, Bioloogia-geograafiateaduskond
Inimese papilloomiviiruse (HPV) genoomi stabiilse replikatsiooni uurimine	-	magistrikraad	Mart Ustav	Kaitstud	2009	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut
Inimese papilloomiviiruse E1 valgu replikatsioonifunktsiooni uurimine	-	doktorikraad	Ene Ustav; Mart Ustav	Juhendamisel		Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut
Melanoomi antigeeni türosinaasi immuundominantsete regioonide kindlakstegemine kasutades türosinaasi-vastaseid monoklonaalseid antikehi	Nele Jaanson	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	2006	Tartu Ülikool, Arstiteaduskond
Modulation of viral DNA replication by tumor suppressor protein p53	-	doktorikraad	Mart Ustav	Kaitstud	2000	Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut
Molecular Studies of HPV-18 Segregation and Stable Replication	Ustav, Mart	doktorikraad	Andres Männik; Mart Ustav	Kaitstud	2016	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Molecular variation of HIV-1 and the use of this knowledge in vaccine development	-	doktorikraad	Richard Villems; Mart Ustav	Kaitstud	2009	Tartu Ülikool
Mudelsüsteemi loomine koletsüstokiniiniretseptorite CCK-A ja CCK-B signaaliülekande radade uurimiseks	-	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	1999	Tartu Ülikool
Multiepitoopse antigeeni konstrueerimine ja sünteetilise antigeeni vastase immuunvastuse analüüs	-	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	2003	Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut
Nakkushaiguste molekulaardiagnostiliste meetodite väljatöötamine	-	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	2003	Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut
NMR spectroscopic studies of calmodulin plasticity in calcium signalling	-	doktorikraad	Mart Ustav	Kaitstud	2007	Georg August Universität Göttingen
Novel means to target Human Papillomavirus infection	Mart Toots	doktorikraad	Ene Ustav; Mart Ustav	Kaitstud	2016	Tartu Ülikool, Loodus- ja täppisteaduste valdkond, Tehnoloogiainstituut
p53 blokeerib papilloomiviiruste amplifikatsioonilist replikatsiooni	-	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	1998	Tartu Ülikool
Papillomavirus Replication Machinery Induces Genomic Instability in its Host Cell	-	doktorikraad	Mart Ustav	Kaitstud	2009	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut
Papilloomiviiruse L1 valgul põhinevate viiruslaadsete partiklite moodustamine in vitro	-	magistrikraad (teaduskraad)	Reet Kurg; Mart Ustav	Kaitstud	2004	Tartu Ülikool, Bioloogia-geograafiateaduskond
RNA-Dependent RNA Polymerase Activity as a Basis for the Detection of Positive-Strand RNA Viruses by Vertebrate Host Cells	-	doktorikraad	Mart Ustav	Kaitstud	2014	Tartu Ülikool, Loodus- ja tehnoloogiateaduskond
Role of virus - host interactions in the regulation of human papillomavirus genome replication	-	doktorikraad	Mart Ustav; Ene Ustav	Juhendamisel		Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut
Specific Monoclonal Antibodies as Tools for Studying Structure-function Relationship of HCV RNA-dependent RNA-polymerase	-	magistrikraad (teaduskraad)	Mart Ustav	Kaitstud	2004	Tartu Ülikool, Bioloogia-geograafiateaduskond, Molekulaar- ja rakubioloogia instituut

Tüüp	Prioriteedi number	Prioriteedi kuupäev	Prioriteedi klassifikaator	Pealkiri	Autorid	Asutused

Patentne leiutis	PCT/EE01/00001	26.02.2001	Rahvusvaheline (IPC)	Peptide tag for monitoring and purification of proteins	Mart Ustav; Niilo Kaldalu; Reet Kurg	Quattromed OÜ
Patentne leiutis		14.07.2011	Rahvusvaheline (IPC)	Alfaviiruse replikaasi kodeeriv ekspressioonivektor ja selle kasutamine immunoloogilise adjuvandina	Katrin Kaldma; Rein Sikut; Kaja Kiiver; Tarmo Mölder; Andres Männik; Mart Ustav	FIT Biotech Oyj Plc Eesti filiaal
Patentne leiutis	P200700012	28.03.2007	Rahvusvaheline (IPC)	Meetod muudatuste sisseviimiseks eukarüootsesse genoomi in vivo ja vastav vahend	Mart Ustav; Ene Ustav; Meelis Kadaja; Alina Sumerina	Tartu Ülikool, Loodus- ja täppisteaduste valdkond, Füüsika instituut; Eesti Nanotehnoloogiate Arenduskeskuse AS
Patentne leiutis	PCT/EE2010/000010	19.05.2010	Rahvusvaheline (IPC)	Method and a kit for identifying compounds capable of inhibiting human papilloma virus replication	Mart Ustav; Ene Ustav; Jelizaveta Geimanen; Regina Pipitš; Helen Isok-Paas; Tormi Reinson; Mart Ustav; Triin Laos; Marit Orav; Anu Remm; Kristiina Salk; Andres Männik	Icosagen Cell Factory OÜ
Patentne leiutis	20010922	3.05.2001	Rahvusvaheline (IPC)	Novel expression vectors and uses thereof	Andres Männik; Kai Krohn; Vesna Blazevic; Marja Tähtinen; Mart Ustav; Urve Toots; Annamari Ranki; Ene Ustav; Mart Ustav; Ene Ustav; Urve Toots	FIT BIOTECH OYJ PLC
Patentne leiutis	US2003170615	26.02.2001	Rahvusvaheline (IPC)	Peptide tag for monitoring and purification of proteins	Mart Ustav; Reet Kurg; Niilo Kaldalu	Quattromed AS
Patentne leiutis	20031319	15.09.2003	Rahvusvaheline (IPC)	SELECTION SYSTEM CONTAINING NON-ANTIBIOTIC RESISTANCE SELECTION MARKER.	Tanel Tenson; Tenson, Laht, Adojaan, Männik, Toots, Ustav; Silja Laht; Maarja Adojaan; Andres Männik; Urve Toots; Mart Ustav; Tanel Tenson; Maarja Adojaan; Urve Toots; Mart Ustav; Silja Laht	Finnish Immunotechnology; FIT BIOTECH OYJ PLC
Patentne leiutis		2.04.2007	Rahvusvaheline (IPC)	Transreplicase Constructs	Andres Merits; Mart Ustav; Andres Männik; Rein Sikut; Kaja Kiiver; Valeria Lulla; Aleksei Lulla; Liane Viru; Tarmo Mölder; Urve Toots	FIT Biotech Oyj Plc Eesti filiaal
Patentne leiutis	60/434,666	20.12.2002	Rahvusvaheline (IPC)	VECTORS LACKING AN ORIGIN OF REPLICATION FUNCTIONING IN MAMMALIAN CELLS AND EXPRESSING GROWTH FACTORS	Andres Männik; Urve Toots; Rein Sikut; Urve Toots; Urve Toots; Rein Sikut; Mart Ustav	FIT BIOTECH OYJ PLC
Muu ...	60/652390	11.02.2005	USA (USPC)	Vektorid ja rakuliinid hübriidsete plasmiidide pikaajaliseks episomaalseks paljundamiseks ja geeniproduktide tootmiseks	Toomas Silla; Ingrid Tagen; Jelizaveta Geimanen; Kadri Janikson; Aare Abroi; Ene Ustav; Mart Ustav; Tiiu Mandel	Rakuvabrik OÜ

Eesti Teadusinfosüsteem

Mart Ustav

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Mart Ustav

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