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Mart Ustav

https://www.etis.ee/CV/Mart_Ustav_001/est
16.07.1949
+3725098600; +3725225418
+3725225418
mart.ustav@ut.ee; mart.ustav@icosagen.com

Teenistuskäik

 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
TÜ MRI Mikrobioloogia ja viroloogia õppetooli juhataja alates 1992.a.
2. TÜ MRI juhataja 1996 - 1999.
3. ETF Keemia ja molekulaarbioloogia ekspertkomisjoni liige, alamkomisjoni esimees
4. TÜMRI Nõukogu liige.
5. TÜ Bio.-Geo. Teaduskonna Nõukogu Liige.
6. EBK Nõukogu liige.
7. TÜ Strateegilise Kompetentsikeskuse Nõukogu liige.
8. Soome TA ekspertkomisjoni liige ja ekspertkomisjoni esimees

Kvalifikatsioon

Teaduspreemiad ja tunnustused
2001, Mart Ustav, Valgetähe 3. järgu orden
1996, Mart Ustav, Eesti teaduspreemia papilloomiviiruste replikatsiooni ja onkogeenide toimemehhanismide uurimise eest.
1980, Mart Ustav, Eesti NSV preemia valgu biosünteesi mehhanismide uurimise eest.
 
 
Lisainfo
Keemiakandidaat
1979

Publikatsioonid

17.02.2021

Mart Ustav

https://www.etis.ee/CV/Mart_Ustav_001/eng
16.07.1949
+3725098600; +3725225418
+3725225418
mart.ustav@ut.ee; mart.ustav@icosagen.com

Career

Institutions and positions
2008–...   
Icosagen Cell Factory OÜ, Chief Executive Officer (1,00)
01.01.2007–...   
University of Tartu, TUIT professor of Biomedical Technology (0,90)
2001–...   
Estonian Academy of Sciences, Academician (1,00)
2007–2012   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Professor (1,00)
01.09.2002–31.08.2007   
University of Tartu, Faculty of Science and Technology (old), Institute of Technology, University of Tartu, Director (1,00)
01.02.2002–31.01.2007   
University of Tartu, Faculty of Biology and Geography, Institute of Molecular and Cell Biology, Professor (1,00)
01.01.2002–31.12.2007   
Director of Tartu University Institute of Technology
2000–2011   
FIT Biotech Oyj Plc, Chief Scientific Officer (1,00)
1996–1999   
Tartu University Institute of Molecular and Cell Biology, Head of the Tartu University Institute of Molecular and Cell Biology (1,00)
1992–31.12.2007   
Department of Microbiology and Virology, Tartu University, Professor (1,00)
1989–1992   
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, Visiting scientist (1,00)
1985–1989   
Laboratory of Oncogenesis, Tartu University and Estonia Biocentre, Head of the Laboratory of Oncogenesis, Tartu University (1,00)
1982–1985   
Uppsala Ülikooli Meditsiinilise Geneetika Instituut, Post-doctoral training (1,00)
1979–1985   
University of Tartu, Senior Researcher (1,00)
1976–1979   
University of Tartu, Junior Researcher (1,00)
1974–1975   
Inst. of Cybernetics Estonian Academy of Sciences, Junior Scientist (1,00)
1972–1974   
Army, Service (1,00)
1967–1972   
TRÜ Füüsika-keemia teaduskond, keemiaosakonna üliõpilane (1,00)
 
 
R&D related managerial and administrative work
TÜ MRI Mikrobioloogia ja viroloogia õppetooli juhataja alates 1992.a.
2. TÜ MRI juhataja 1996 - 1999.
Chairman of the Chemistry and Molecular Biology subcommittee of the Estonian Science Foundation
Member of Council, Tartu University's Institute of Molecular and Cell Biology
Member of Council, Tartu University's Faculty of Biology and Geography
Member of Council of the Estonian Biocentre
Member of Council of Tartu University's Centre of Strategical Competence
Member of expert committe of the Finnish Academy of Sciences and the chairman of an expert committee

Qualifications

Academic degrees
Mart Ustav, Doctor's Degree, 1979, (sup) Richard Villems, The interaction of 5S RNA and tRNA with the ribosomal proteins of Escherichia coli (The interaction of 5S RNA and tRNA with the ribosomal proteins of Escherichia coli), Kiiev.
 
 
Honours & awards
2001, Mart Ustav, order of the white star 3 class
1996, Mart Ustav, Research Prize or Estonia for research in the field of papillomaviruses
1980, Mart Ustav, Research Prize of Estonia for research in the field of protein synthesis
 
 
Additional information
Ph.D. (Cand. Chem.Sciences in Molecular Biology)
1979

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2019
Tombak, EM.; Männik, A.; Burk, RD.; Le Grand, R.; Ustav, E.; Ustav M. (2019). The molecular biology and HPV drug responsiveness of cynomolgus macaque papillomaviruses support their use in the development of a relevant in vivo model for antiviral drug testing. PLoS ONE, 14 (1).10.1371/journal.pone.0211235.
1.1.
2018
Henno, Liisi; Tombak, Eva-Maria, Geimanen Jelizaveta; Orav, Marit; Ustav, Ene; Ustav, Mart. (2018). Analysis of human papillomavirus genome replication using two- and three-dimensional agarose gel-electrophoresis. Current Protocols in Microbiology, 45 (1), x−x.10.1002/cpmc.28.
1.1.
2017
Toots, Mart; Ustav, Mart Jr.; Männik, Andres; Mumm, Karl; Tämm, Kaido; Tamm, Tarmo; Ustav, Ene; Ustav, Mart. (2017). Identification of several high-risk HPV inhibitors and drug targets with a novel high-throughput screening assay. PLoS Pathogens, 13 (2), e1006168. DOI: 10.1371/journal.ppat.1006168.
1.1.
2016
Kurg, Reet; Reinsalu, Olavi; Jagur, Sergei; Õunap, Kadri; Võsa, Liisi; Kasvandik, Sergo; Padari, Kärt; Gildemann, Kiira; Ustav, Mart (2016). Biochemical and proteomic characterization of retrovirus Gag based microparticles carrying melanoma antigens. Scientific Reports, 6 (29245), 1−11. DOI: 10.1038/srep29425.
1.1.
2016
Kivi, Gaily; Teesalu, Kaupo; Parik, Jüri; Kontkar, Elen; Ustav, Mart; Noodla, Liis; Ustav, Mart; Männik, Andres (2016). HybriFree: a robust and rapid method for the development of monoclonal antibodies from different host species. BMC Biotechnology, 16 (1), 2−2. DOI: 10.1186/s12896-016-0232-6.
1.1.
2015
Reinson, Tormi; Toots, Mart; Ustav, Mart Jr;Ustav, Mart. (2015). The Cell Cycle Timing of Human Papillomavirus DNA Replication. PLoS ONE, 10 (7), 1−16.10.1371/journal.pone.0131675.
1.1.
2015
Ustav, Mart Jr; Castaneda, Fernando-Rodriguez; Reinson, Tormi; Männik, Andres; Ustav, Mart (2015). Human Papillomavirus Type 18 cis-Elements Crucial for Segregation and Latency. PLoS ONE, 10 (8), 1−24. DOI: 10.1371/journal.pone.0135770.
1.1.
2015
Kivipõld, P.; Võsa, L.; Ustav, M.; Kurg, R. (2015). DAXX modulates human papillomavirus early gene expression and genome replication in U2OS cells. Virology Journal, 12, 104.10.1186/s12985-015-0335-z.
1.1.
2015
Sankovski, Eve; Karro, Kristiina; Sepp, Mari; Kurg, Reet; Ustav, Mart; Abroi, Aare (2015). Characterization of the nuclear matrix targeting sequence (NMTS) of the BPV1 E8/E2 protein - the shortest known NMTS. Nucleus, 289−300. DOI: 10.1080/19491034.2015.1074359.
1.1.
2015
Isok-Paas, Helen; Männik, Andres; Ustav, Ene; Ustav, Mart. (2015). The transcription map of HPV11 in U2OS cells adequately reflects the initial and stable replication phases of the viral genome. Virology Journal, 1−15.
3.1.
2015
Karro, Kristiina; Männik, Tiiu; Männik, Andres; Ustav, Mart (2015). DNA Transfer into Animal Cells Using Stearylated CPP Based Transfection Reagent. In: Ülo Langel (Ed.). Cell-Penetrating Peptides (435−445). New York: Springer. (Methods in Molecular Biology; 1324).10.1007/978-1-4939-2806-4_29.
1.1.
2014
Toots, Mart; Männik, Andres; Kivi, Gaili; Ustav, Mart JR.; Ustav, Ene; Ustav, Mart (2014). The Transcription Map of Human Papillomavirus Type 18 during Genome Replication in U2OS Cells. PLoS ONE, 9 (12), 1−31.
1.1.
2014
Sankovski, Eve; Männik, Andres; Geimanen, Jelizaveta; Ustav, Ene; Ustav, Mart (2014). Mapping of Beta-Papillomavirus HPV5 Transcription and Characterization of Viral Genome Replication Function. Journal of Virology, 88 (2), 961−973.
6.6.
2014
Ustav, Mart; Soomere, Tarmo (2014). Eesti Teaduste Akadeemia presidendiks kandideerivad Mart Ustav ja Tarmo Soomere / Margus Maidla, intervjueerija. Sirp, 35−37.
1.1.
2013
Toots, Mart; Männik, Andres; Kivi, Gaily; Ustav Jr., Mart; Ustav, Ene; Ustav, Mart (2013). http://www.ncbi.nlm.nih.gov/pubmed/25548925. PLoS ONE, 9 (12), 1−31.10.1371/journal.pone.0116151.
1.1.
2013
Orav, Marit; Henno, Liisi; Isok-Paas, Helen; Geimanen, Jelizaveta; Ustav, Mart; Ustav, Ene (2013). Recombination-Dependent Oligomerization of Human Papillomavirus Genomes upon Transient DNA Replication. Journal of Virology, 87 (22), 12051−12068.10.1128/JVI.01798-13.
1.1.
2013
Nikonov, A.; Mölder, T.; Sikut, R.; Kiiver, K.; Männik, A.; Toots, U.; Lulla, A.; Lulla, V.; Utt, A.; Merits, A.; Ustav, M. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLoS Pathogens, 9 (9), e1003610.10.1371/journal.ppat.1003610.
1.1.
2013
Arukuusk, P.; Pärnaste, L.; Oskolkov, N.; Copolovici, D. M.; Margus, H.; Padari, K.; Möll, K.; Maslovskaja, J.; Tegova, R.; Kivi, G.; Tover, A.; Pooga, M.; Ustav, M.; Langel, Ü. (2013). New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1828 (5), 1365−1373. DOI: 10.1016/j.bbamem.2013.01.011.
1.1.
2013
Reinson, Tormi; Toots, Mart; Kadaja, Meelis; Pipitch, Regina; Allik, Mihkel; Ustav, Ene; Ustav, Mart (2013). Engagement of the ATR-Dependent DNA Damage Response at the Human Papillomavirus 18 Replication Centers during the Initial Amplification. Journal of Virology, 87 (2), 951−964.10.1128/JVI.01943-12.
1.1.
2012
Võsa, L; Sudakov, A; Remm, M; Ustav, M; Kurg, R. (2012). Identification and analysis of papillomavirus E2 protein binding sites in the human genome. Journal of Virology, 86 (1), 348−357. DOI: 10.1128/JVI.05606-11.
1.1.
2012
Vardas, E.; Stanescu, I.; Leinonen, M.; Ellefsen, K.; Pantaleo, G.; Valtavaara, M.; Ustav, M.; Reijonen, K. (2012). Indicators of therapeutic effect in FIT-06, a Phase II trial of a DNA vaccine, GTU(®)-Multi-HIVB, in untreated HIV-1 infected subjects. Vaccine, 8, 4046−4054.10.1016/j.vaccine.2012.04.007.
1.1.
2011
Geimanen, J.; Isok-Paas, H.; Pipitch, R.; Salk, K.; Laos, T.; Orav, M.; Reinson, T.; Ustav, M. Jr.; Ustav, M.; Ustav, E. (2011). Development of a cellular assay system to study the genome replication of high- and low-risk mucosal and cutaneous human papillomaviruses. Journal of Virology, 85 (7), 3315−3329.
1.1.
2010
Kurg, R; Uusen, P; Võsa, L; Ustav, M (2010). Human papillomavirus E2 protein with single activation domain initiates HPV18 genome replication, but is not sufficient for long-term maintenance of virus genome. Virology, 408 (2), 159−166.10.1016/j.virol.2010.09.010.
1.1.
2010
Silla, Toomas; Männik, Andres; Ustav, Mart (2010). Effective Formation of the Segregation-Competent Complex Determines Successful Partitioning of the Bovine Papillomavirus Genome during Cell Division. Journal of Virology, 84 (21), 11175−11188. DOI: 10.1128/JVI.01366-10.
1.1.
2009
Martinon, F.; Kaldma, K.; Sikut, R.; Culina, S.; Romain, G.; Tuomela, M.; Adojaan, M.; Männik, A.; Toots, U.; Kivisild, T.; Morin, J.; Brochard, P.; Delache, B.; Tripiciano, A.; Ensoli, F.; Stanescu, I.; Le Grand, R.; Ustav, M. (2009). Persistent Immune Responses Induced by a Human Immunodeficiency Virus DNA Vaccine Delivered in Association with Electroporation in the Skin of Nonhuman Primates. Human Gene Therapy, 20 (11), 1291−1307. DOI: 10.1089/hum.2009.044.
1.1.
2009
Kadaja, M.; Isok-Paas, H.; Laos, T.; Ustav, E.; Ustav, M. (2009). Mechanism of Genomic Instability in Cells Infected with the High-Risk Human Papillomaviruses. PLoS Pathogens, e1000397−e1000397. DOI: 10.1371/journal.ppat.1000397.
1.1.
2009
Kadaja, M; Silla, T; Ustav, E; Ustav, M. (2009). Papillomavirus DNA replication - from initiation to genomic instability. Virology, 384 (2), 360−368. DOI: 10.1016/j.virol.2008.11.032.
1.1.
2009
Kurg, R.; Uusen, P.; Sepp, T.; Sepp, M.; Abroi, A.; Ustav, M. (2009). Bovine papillomavirus type 1 E2 protein heterodimer is functional in papillomavirus DNA replication in vivo. Virology, 386 (2), 353−359. DOI: 10.1016/j.virol.2009.01.025.
1.1.
2008
Nikonov, A.; Juronen, E.; Ustav, M. (2008). Functional characterization of fingers subdomain-specific monoclonal antibodies inhibiting the hepatitis C virus RNA-dependent RNA polymerase. Journal of Biological Chemistry, 283 (35), 24089−24102. DOI: 10.1074/jbc.M803422200.
1.1.
2007
Rausalu, K.; Karo-Astover, L.; Kilk, A.; Ustav, M. (2007). CuZn-SOD suppresses the Bovine Papillomavirus-induced proliferation of fibroblasts. Apmis, 115 (12), 1415−1421. DOI: 10.1111/j.1600-0463.2007.00779.x.
1.1.
2007
Kadaja, M.; Sumerina, A.; Verst, T.; Ojarand, M.; Ustav, E.; Ustav, M. (2007). Genomic instability of the host cell induced by the human papillomavirus replication machinery. EMBO Journal, 26 (8), 2180−2191.
1.1.
2007
Adojaan, M.; Mölder, T.; Männik, A.; Kivisild, T.; Villems, R.; Krispin, T.; Ustav, M. (2007). High prevalence of the CCR5delta32 HIV-resistance mutation among Estonian HIV-1-infected individuals. Aids Research and Human Retroviruses, 23 (2), 193−197. DOI: 10.1089/aid.2006.0113.
1.1.
2006
Kiiver, K.; Merits, A.; Ustav, M.; Žusinaite, E. (2006). Complex formation between hepatitis C virus NS2 and NS3 proteins. Virus Research, 117 (2), 264−272.
1.1.
2006
Ilves, I.; Mäemets, K.; Silla, T.; Janikson, K.; Ustav, M. (2006). Brd4 is involved in multiple processes of bovine papillomavirus BPV1 life cycle. Journal of Virology, 80 (7), 3660−3665.
1.1.
2006
Kilk, A.; Rausalu, K.; Ustav, M. (2006). Bovine papillornavirus type 1 oncoprotein E5 stimulates the utilization of superoxide radicals in the mouse fibroblast cell line C127. Chemico-Biological Interactions, 159 (3), 205−212.
1.1.
2005
Kurg, R.; Sild, K.; Ilves, A.; Sepp, M.; Ustav, M. (2005). Association of bovine papillomavirus E2 protein with nuclear structures in vivo. Journal of Virology, 79 (16), 10528−10539.
1.1.
2005
Silla, T.; Haal, I.; Geimanen, J.; Janikson, K.; Abroi, A.; Ustav, E.; Ustav, M. (2005). Episomal maintenance of plasmids with hybrid origins in mouse cells. Journal of Virology, 79 (24), 15277−15288.
1.1.
2004
Abroi, A.; Kivi, S.; Ves, I. ; Ustav, M. (2004). Analysis of chromatin attachment and partitioning functions of bovine papillomavirus type 1 E2 protein. Journal of Virology, 78 (4), 2100−2113.
1.1.
2003
Ilves, I.; Kadaja, M.; Ustav, M. (2003). Two separate replication modes of the bovine papillomavirus BPV1 origin of replication that have different sensitivity to p53. Virus Research, 96, 75−84.
1.1.
2003
Mannik, A.; Piirsoo, M.; Nordstrom, K.; Ustav, E.; Vennstrom, B.; Ustav, M. (2003). Effective generation of transgenic mice by Bovine papillomavirus type 1 based self-replicating plasmid that is maintained as extrachromosomal genetic element in three generations of animals. Plasmid, 49 (3), 193−204.
1.1.
2003
Jaanson, N.; Moll, K.; Kulla, A.; Ustav, M. (2003). Identification of the immunodominant regions of the melanoma antigen tyrosinase by anti-tyrosinase monoclonal antibodies. Melanoma Research, 13 (5), 473−482.
1.1.
2002
Andreson, H.; Loivukene, K.; Sillakivi, T.; Maaroos, HI.; Ustav, M.; Peetsalu, A.; Mikelsaar, M. (2002). Association of cagA and vacA genotypes of Helicobacter pylori with gastric diseases in Estonia. Journal of Clinical Microbiology, 40 (1), 298−300.
1.1.
2002
Mannik, A.; Runkorg, K.; Jaanson, N.; Ustav, M.; Ustav, E. (2002). Induction of the bovine papillomavirus origin "onion skin"-type DNA replication at high E1 protein concentrations in vivo. Journal of Virology, 76 (11), 5835−5845.
1.1.
2002
Tammur, J.; Sibul, H.; Ustav, E.; Ustav, M.; Metspalu, A. (2002). A bovine papillomavirus-I based vector restores the function of the low-density lipoprotein receptor in the receptor-deficient CHO-ldlA7 cell line (vol 3, art no 5, 2002). BMC Molecular Biology, 3, -.
1.1.
2002
Tammur, J.; Sibul, H.; Ustav, E.; Ustav, M.; Metspalu, A. (2002). A bovine papillomavirus-1 based vector restores the function of the low-density lipoprotein receptor in the receptor-deficient CHO-ldlA7 cell line. BMC Molecular Biology, 3, -.
1.1.
2001
Tähtinen, M.; Strengell, M.; Collings, A.; Pitkänen, J.; Hakkarainen, K.; Ustav, M.; Wahren, B.; Peterson, P.; Kohleisen, B.; Ranki, A.; Krohn, K. (2001). DNA vaccination in mice using HIV-1 nef, rev and tat genes in self-replicating bovine papilloma virus based pBN-vector. Vaccine, 19, 2039−2047.
1.1.
2001
Kivimae, S.; Allikas, A.; Kurg, R.; Ustav, M. (2001). Replication of a chimeric origin containing elements from Epstein-Barr virus ori P and bovine papillomavirus minimal origin. Virus Research, 75 (1), 1−11.
1.1.
2001
Sillakivi, T.; Aro, H.; Ustav, M.; Peetsalu, M.; Peetsalu, A.; Mikelsaar, M. (2001). Diversity of Helicobacter pylori genotypes among Estonian and Russian patients with perforated peptic ulcer, living in Southern Estonia. FEMS Microbiology Letters, 195 (1), 29−33.
1.1.
2001
Allikas, A.; Ord, D.; Kurg, R.; Kivi, S.; Ustav, M. (2001). Roles of the hinge region and the DNA binding domain of the bovine papillomavirus type 1 E2 protein in initiation of DNA replication. Virus Research, 75 (2), 95−106.
1.1.
2001
Vali, U.; Kilk, A.; Ustav, M. (2001). Bovine papillomavirus oncoprotein E5 affects the arachidonic acid metabolism in cells. The International Journal of Biochemistry & Cell Biology, 33 (3), 227−235.
1.1.
2001
Koljak, R.; Jarving, I.; Kurg, R.; Boeglin, WE.; Varvas, K.; Valmsen, K.; Ustav, M.; Brash, AR.; Samel, N. (2001). The basis of prostaglandin synthesis in coral - Molecular cloning and expression of a cyclooxygenase from the Arctic soft coral Gersemia fruticosa. Journal of Biological Chemistry, 276 (10), 7033−7040.
1.2.
2001
Raasmaja, A.; Soosaar, A.; Lampela, P.; Kõks, S.; Männik, A.; Volke, V.; Huotari, M.; Joki, S.; Ustav, E.; Vasar, E.; Ustav, M.; Männistö, P. (2001). Tyrosine Hydroxylase gene Transfer to Rat Striatum Using Bovine Papilloma Virus-1 Expression Plasmids in the Experimental Model of Parkinson's Disease. In: Pharmaceutical and Pharmacological Letters (83−86). . (2).
1.1.
2000
Zusinaite, E.; Krispin, T.; Raukas, E.; Kiiver, K.; Salupere, R.; Ott, K.; Ustina, V.; Zilmer, K.; Schmidt, J.; Sizemski, L.; Jaago, K.; Luman, M.; Ilmoja, M.; Prukk, T.; Ustav, M. (2000). Hepatitis C virus genotypes in Estonia. Apmis, 108 (11), 739−746.
1.1.
2000
Kaldalu, N.; Toots, U.; de Lorenzo, V.; Ustav, M. (2000). Functional domains of the TOL plasmid transcription factor XylS. Journal of Bacteriology, 182 (4), 1118−1126.
1.1.
2000
Lepik, D.; Ustav, M. (2000). Cell-specific modulation of papovavirus replication by tumor suppressor protein p53. Journal of Virology, 74 (10), 4688−4697.
1.1.
2000
Loivukene, K.; Kolk, H.; Maaroos, HI.; Kasenomm, P.; Aro, H.; Ustav, M.; Mikelsaar, M. (2000). Metronidazole and clarithromycin susceptibility and the subtypes of VacA of Helicobacter pylori isolates in Estonia. Scandinavian Journal of Infectious Diseases, 32 (1), 59−62.
1.1.
2000
Kaldalu, N.; Lepik, D.; Kristjuhan, A.; Ustav, M. (2000). A Novel Immunotag System for Monitoring and Purification of Proteins. BioTechniques, 28 (3), 456−462.
3.2.
2000
Kurg, R; Ustav, M. (2000). Update to: Monitoring and Purification of Proteins Using Bovine Papillomavirus E2 Epitope Tags. Lu,Q.; M.P. Weiner. Cloning and Expression Vectors for Protein Studies (Chapter 27). . Weiner: Eaton Publishing Co.
5.2.
2000
Zusinaite, E.; Krispin, T.; Raukas, E.; Kiiver, K.; Salupere, R.; Ott, K.; Ustina, V.; Zilmer, K.; Schmidt, J.; Zisemski, L.; Jaago, K.; Luman, M.; Ilmoja, M.; Prükk, T.; Ustav, M. (2000). Hepatitis C virus genotypes in Estonia. 4th Nordic-Baltic Congress on Infectious Diseases "Prudent use of antibiotics", 17.05.-19.05.2005, Tallinn. Tallinn: Oriola, 50.
1.1.
1999
Koljalc, S.; Sults, I.; Raukas, E.; Truu, J.; Ustav, M.; Mikelsaar, M. (1999). Distribution of Acinetobacter baumannii in a neurointensive care unit. Scandinavian Journal of Infectious Diseases, 31 (2), 145−150.
1.1.
1999
Collings, A.; Pitkanen, J.; Strengell, M.; Tahtinen, M.; Pitkanen, J.; Lagerstedt, A.; Hakkarainen, K.; Ovod, V.; Sutter, G.; Ustav, M.; Ustav, E.; Mannik, A; Ranki, A; Peterson, P.; Krohn, K. (1999). Humoral and cellular response to HIV-1 Nef in mice DNA-immunized with non-replicating and self-replicating expression vectors. Vaccine, 18, 460−467.
1.1.
1999
Prükk, T.; Raukas, E.; Martin, M.; Ustav, M. (1999). Prevalence of Ticks Infected with Borrelia burgdorferi in Estonia. Zentralblatt für Bakteriologie-International Journal of Medical Microbiology Virology Parasitology and Infectious Diseases, 289, 706−710.
1.1.
1999
Remm, M.; Remm, A.; Ustav, M. (1999). Human papillomavirus type 18 E1 protein is translated from polycistronic mRNA by a discontinuous scanning mechanism. Journal of Virology, 73 (4), 3062−3070.
1.1.
1999
Ilves, I.; Kivi, S.; Ustav, M. (1999). Long-term episomal maintenance of bovine papillomavirus type 1 plasmids is determined by attachment to host chromosomes, which is mediated by the viral E2 protein and its binding sites. Journal of Virology, 73 (5), 4404−4412.
5.1.
1999
Loivukene, K.; Kolk, H.; Mikelsaar, M.; Kasenomm, P.; Ustav, M.; Maaroos, HI. (1999). Comparison of metronidazole susceptibility and vacA subtypes of H-pylori strains in patients with gastritis and peptic ulcer. Gut, 45, A14−A14.
5.1.
1999
Kivi, S.; Ilves, I.; Ustav, M. (1999). Association of bovine papillomavirus type 1 plasmids to host chromosomes and their long-term episomal maintenance is mediated by the viral E2 protein and its binding sites. Cytogenetics and Cell Genetics, 85, 113−113.
5.1.
1999
Ustav, E.; Mannik, A.; Mandel, T.; Runkorg, K.; Piirsoo, M.; Nordstrom, K.; Vennstrom, B.; Ustav, M. (1999). Generation and analysis of the BPV-1 based vector system for gene therapy. Human Gene Therapy, 10 (5), 852−852.
1.1.
1998
Koks, S.; Soosaar, A.; Voikar, V.; Volke, V.; Ustav, M.; Mannisto, PT.; Bourin, M.; Vasar, E. (1998). Opioid antagonist naloxone potentiates anxiogenic-like action of cholecystokinin agonists in elevated plus-maze. Neuropeptides, 32 (3), 235−240.
1.1.
1998
Lepik, D.; Ilves, I.; Kristjuhan, A.; Maimets, T.; Ustav, M. (1998). p53 protein is a suppressor of papillomavirus DNA amplificational replication. Journal of Virology, 72 (8), 6822−6831.
1.2.
1998
Ustav, E.; Ustav, M. (1998). E2 protein as the master regulator of extrachromosomal replication of the papillomaviruses. Papillomavirus Report, 9, 145−152.
1.1.
1996
Piirsoo, M.; Ustav, E.; Mandel, T.; Stenlund, A.; Ustav, M. (1996). Cis and trans requirements for stable episomal maintenance of the BPV-1 replicator. EMBO Journal, 15 (1), 1−11.
1.1.
1996
Kaldalu, N.; Mandel, T.; Ustav, M. (1996). TOL plasmid transcription factor XylS binds specifically to the Pm operator sequence. Molecular Microbiology, 20 (3), 569−579.
1.1.
1996
Kilk, A.; Talpsepp, T.; Vali, U.; Ustav, M. (1996). Bovine papillomavirus oncoprotein E5 induces the NF kappa B activation through superoxide radicals. Biochemistry and Molecular Biology International, 40 (4), 689−697.
1.1.
1996
Abroi, A.; Kurg, R.; Ustav, M. (1996). Transcriptional and replicational activation functions in the bovine papillomavirus type 1 E2 protein are encoded by different structural determinants. Journal of Virology, 70 (9), 6169−6179.
5.1.
1995
Ustav, M.; Talpsepp, T.; Kilk, A.; Väli, Ü.; Burnett, S. (1995). Overexpression of the BPV-1 E5 oncoprotein induces an apoptosis. Abstracts of papers presented at the Imperail Cancer Research Fund Tumour Virus Meeting on PapovavirusesPapillomaviruses and Adenoviruses 17-22 July, 1995, Churchill College: Tumour Virus Meeting on Papovaviruses Papillomaviruses and Adenoviruses; Churchill College; 17-22 July, 1995. Cambridge, England, 137.
1.1.
1994
Aleshkov, SB.; Ustav, MB.; Baev, AA. (1994). Recombinant mouse-cell lines transformed with different type-1 bovine papilloma virus-based vectors and expressing human tissue-plasminogen activator. 1. Analysis of cell-lines producing recombinant tissue-plasminogen activator. Molecular Biology, 28 (3), 411−414.
5.1.
1994
Sedman, J.; Ustav, M.; Stenlund, A. (1994). Dna-replication of papillomaviruses. Journal of Cellular Biochemistry, 211−211.
1.1.
1993
Ustav, E.; Ustav, M.; Szymanski, P.; Stenlund, A. (1993). The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator. Proceedings of the National Academy of Sciences, 90 (3), 898−902.
5.2.
1993
Talpsepp, T.; Kilk, A.; Ustav, M.; Zilmer, M. (1993). The bovine papilloma virus encoded E5 oncoprotein action mechanism in cell transformation. Microbiological research in Estonia: information on research projects. Tartu: Estonian Society for Microbiology, 8.
1.1.
1991
Aleshkov, SB.; Ustav, MB.; Bayev, AA. (1991). Comparison of usual and modified bpv-based vector properties. Doklady Akademii Nauk SSSR, 318 (6), 1472−1475.
1.1.
1991
Aleshkov, SB.; Ustav, MB.; Baev, AA. (1991). Expression of human tissue plasminogen-activator by recombinant cell-lines of various animals. Molecular Biology, 25 (5), 960−970.
1.1.
1991
Aleshkov, SB.; Ustav, MB.; Baev, AA. (1991). Recombinant mouse-cell lines transformed by various vectors based on bovine type-1 papillomavirus and expressing human tissue plasminogen-activator. Molecular Biology, 25 (5), 971−977.
1.2.
1991
Ustav, M.; Ustav, E.; Szymanski, P.; Stenlund, A. (1991). Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1. EMBO Journal, 10 (13), 4321−4329.
1.1.
1989
Aleshkov, SB.; Ustav, MB.; Baev, AA. (1989). Expression of human tpa cdna in human-cells under different eukaryotic promoters. Doklady Akademii Nauk SSSR, 309 (3), 721.
1.1.
1988
Bergman, P.; Ustav, M.; Sedman, J.; Morenolopez, J.; Vennstrom, B.; Pettersson, U. (1988). The e5 gene of bovine papillomavirus type-1 is sufficient for complete oncogenic transformation of mouse fibroblasts. Oncogene, 2 (5), 453−459.
1.1.
1984
Maimets, T. O.; Ustav, M. B.; Remme, J. L.; Villems, R. L.-E. (1984). The L16 protein of the escherichia-coli ribosome: its possible role in protein biosynthesis. Molecular Biology, 18 (6), 1305−1313.
1.1.
1984
Maimets, TO.; Ustav, MB.; Remme, YL.; Villems, RlE. (1984). The l16 protein of the escherichia-coli ribosome - possible role in protein-biosynthesis. Molecular Biology, 18 (6), 1305−1313.
1.1.
1983
Metspalu, E.; Ustav, M.; Villems, R. (1983). 5-S RNA protein complex is involved in ribosomal-subunit association. FEBS Letters, 153 (1), 125−127.
1.1.
1983
Remme, J.; Maimets, T.; Ustav, M.; Villems, R. (1983). The interaction of ribosomal protein-l16 and its fragments with transfer-rna. FEBS Letters, 153 (2), 267−269.
1.1.
1983
Maimets, T.; Ustav, M.; Villems, R. (1983). The role of protein-l16 and its fragments in the peptidyltransferase activity of 50-s ribosomal-subunits. European Journal of Biochemistry, 135 (1), 127−130.
1.1.
1982
Metspalu, E.; Ustav, M.; Maimets, T.; Villems, R. (1982). The composition and properties of the escherichia-coli 5-s RNA- protein complex. European Journal of Biochemistry, 121 (2), 383−389.
1.1.
1982
Matspalu, E.; Ustav, M.; Villems, R. (1982). The properties of the transfer-RNA. Protein complex of the escherichia-coli ribosome interaction with transfer-rna, 5-s RNA and 30-s ribosomal-subunit. European Journal of Biochemistry, 124 (2), 269−273.
1.1.
1981
Maimets, T. O.; Ustav, M. B.; Villems, R. L.-E.; Saarma, M. J.; Lind, A. J. (1981). Binding of proteins of the Escherichia coli 50 S ribosomal subparticle to two large fragments of 5S RNA. Molecular Biology, 15 (3), 440−445.
1.1.
1981
Metspalu, E.; Maimets, T.; Ustav, M.; Villems, R. (1981). A quaternary complex consisting of 2 molecules of transfer-RNA and ribosomal-proteins L2 and L17. FEBS Letters, 132 (1), 105−108.
1.1.
1981
Maimets, TO.; Ustav, MB.; Villems, RlE.; Saarma, MY.; Lind, AY. (1981). Binding of proteins of the escherichia-coli 50s ribosomal subparticle to 2 large fragments of 5s-rna. Molecular Biology, 15 (3), 440−445.
1.1.
1981
Metspalu, EE.; Ustav, MB.; Villems, RlE. (1981). Complexes of immobilized transfer-RNA and 5s RNA with 50s ribosomal-subunit proteins bind 30s subunit of escherichia-coli ribosome. Биоорганическая химия, 7 (5), 784−786.
1.1.
1981
Sedman, J.; Maimets, T.; Ustav, M.; Villems, R. (1981). The interaction of 5-s-RNA and its large fragments with ribosomal-proteins. FEBS Letters, 136 (2), 251−254.
1.1.
1980
Speek, M.; Ustav, M.; Lind, A.; Saarma, M. (1980). Characterization of the secondary structure of the Escherichia coli 5S RNA using S1 nuclease and cobra venom endonuclease. Bioorganicheskaya Khimiya, 6 (12), 1877−1880.
1.1.
1980
Speek, MA.; Ustav, MB.; Lind, AJ.; Saarma, MJ. (1980). Structural studies of escherichia-coli 5s RNA with s1 nuclease and endonuclease from cobra venom. Bioorganicheskaya Khimiya, 6 (12), 1877−1880.
3.1.
1980
Villems, R.; Koger, A.; Lind, A.; Maimets, T.; Metspalu, E.; Saarma, M.; Sarapuu, T.; Ustav, M. (1980). Affinity chromatography of Escherichia coli ribosomal protein on the immobilized ribonucleic acids. Properties of the complexes. In: Augustyniak, J. (Ed.). Biological implications of protein-nucleic acid interactions (91−99).. Amsterdam: Elsevier.
1.1.
1979
Kesvatera, T.; Ustav, M.; Aaviksaar, A. (1979). Cobra venom acetylcholinesterase. 2. Substrate-specificity. Comparative Biochemistry and Physiology Part C: Comparative Pharmacology, 62 (2), 193−197. DOI: 10.1016/0306-4492(79)90009-1.
1.1.
1979
Ustav, MB.; Remme, JL.; Lind, AJ.; Villems, RlE. (1979). New efficient route to immobilization of ribonucleic-acids and nucleotides on agarose. Bioorganicheskaya Khimiya, 5 (3), 365−369.
1.2.
1979
Saarma, M.; Villems, R.; Laving, A.; Metspalu, A.; Toots, I.; Ustav, M.; Lind, A. (1979). On the origin of eukaryotic 5.8S RNA. Hoppe-Seylers Zeitschrift für Physiologische Chemie, 360, 1040−1041.
1.1.
1978
Ustav, M.; Saarma, M.; Lind, A.; Villems, R. (1978). Domain for transfer ribonucleic-acid binding to escherichia-coli ribosome. FEBS Letters, 87 (2), 315−317.
1.1.
1978
Metspalu, A.; Saarma, M.; Villems, R.; Ustav, M.; Lind, A. (1978). Interaction of 5-s RNA,5.8-s RNA and transfer-RNA with rat-liver ribosomal-proteins. European Journal of Biochemistry, 91 (1), 73−81.
1.1.
1977
Ustav, MB.; Lind, AJ.; Saarma, MJ.; Villems, RlE. (1977). Interaction of 5s RNA with escherichia-coli 30s ribosomal-subunit proteins. Bioorganicheskaya Khimiya, 3 (12), 1699−1701.
1.1.
1977
Ustav, M.; Villems, R.; Lind, A. (1977). Interaction of transfer ribonucleic-acid with 30 s ribosomal-subunit proteins. FEBS Letters, 82 (2), 259−262.
1.1.
1977
Ustav, M.; Villems, R.; Saarma, M.; Lind, A. (1977). Interaction of transfer ribonucleic-acid with 50-s ribosomal-subunit proteins. FEBS Letters, 83 (2), 353−356.
1.1.
1977
Lind, A.; Metspalu, A.; Saarma, M.; Toots, I.; Ustav, M.; Villems, R. (1977). Universal structure of peptidyl transferase center in ribosomes and function of eukaryotic 5.8s ribosomal ribonucleic-acid. Биоорганическая химия, 3 (8), 1138−1140.
1.2.
1977
Lind, A.; Metspalu, A.; Saarma, M.; Toots, I.; Ustav, M.; Villems, R. (1977). Universal structure of the ribosomal peptidyltransferase center and function of the eukaryotic 5,8S rRNA. Bioorganic Chemistry, 3, 1138−1140.

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MJDMJD228Identification of the mammalian chromatin host factor involved in the segregation of the human papillomavirus genome10.02.201221.11.2014Fernando Rodriguez-CastanedaTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut100 580,00 EUR
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ETFETF7670Inimese papilloomiviiruse genoomi stabiilse episomaalse säilumise mehhanismi väljaselgitamine ja ravimiarenduseks sobilike rakuliinide konstrueerimine01.01.200831.12.2011Mart UstavTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond73 885,16 EUR
PRGPRG198Inimese papilloomiviirusega (HPV) nakatumise ja replikatsiooni inhibiitorite märklaudade ja ravimite otsinguks kõrge läbilaskvusega rakulise süsteemi konstrueerimine ning loommudeli loomine pre-kliiniliseks HPV ravimite testimiseks.01.01.201831.12.2022Marko PiirsooTartu Ülikool, Loodus- ja täppisteaduste valdkond, tehnoloogiainstituut914 250,00 EUR
TKRLOTITIPPKeemilise bioloogia tippkeskus07.07.200831.08.2015Tanel TensonTartu Ülikool; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut5 597 382,18 EUR
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1.1.5.2.1.3.IMGEMELNovel immunogenomic approach for characterization of melanoma pathogenesis 01.05.201230.04.2015Mart UstavIcosagen Cell Factory OÜ0,00 EUR
ETFETF5998Papilloomiviiruste genoomi mitootilise retseptori uurimine01.01.200431.12.2007Mart UstavTartu Ülikool; Tartu Ülikool; Tartu Ülikool51 040,75 EUR
1.1.5.2.ILOTI09106KRakupõhine skriinimismeetod HPV DNA replikatsiooni inhibiitorite leidmiseks (eeluuring)01.06.200930.11.2009Mart UstavTartu Ülikool18 965,65 EUR
SFSF_0182566As03RNA ja DNA genoomiga viiruste replikatsioonimehhanismide uurimine ja geeniteraapia ning geenvaktsineerimise uute meetodite väljatöötamine01.01.200331.12.2007Mart UstavTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Tehnoloogiainstituut0,00 EUR
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