Pille Hallast

https://www.etis.ee/CV/Pille_Hallast/est
pille.hallast@ut.ee

Kvalifikatsioon

Teaduskraadid
Pille Hallast, doktorikraad, 2009, (juh) Maris Laan, Human and chimpanzee Luteinizing Hormone/ Chorionic Gonadotropin Beta (LHB/CGB) gene clusters: diversity and divergence of young duplicated genes, Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut.
Pille Hallast, magistrikraad (teaduskraad), 2004, (juh) Maris Laan, Geenikonversiooni roll lokaalsete alleelse aheldatuse (LD) mustrite kujundamises inimese genoomis kooriongonadotropiini beta subühiku (CGB) geeniperekonna näitel, Tartu Ülikool, Bioloogia-geograafiateaduskond.
 
 
Teadustöö põhisuunad
VALDKOND: 1. Bio- ja keskkonnateadused; 1.3. Geneetika

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2019
Shi, Wentao; Louzada, Sandra; Grigorova, Marina; Massaia, Andrea; Arciero, Elena; Kibena, Laura; Ge, Xiangyu Jack; Chen, Yuan; Ayub, Qasim; Poolamets, Olev; Tyler-Smith, Chris; Punab, Margus; Laan, Maris; Yang, Fengtang; Hallast, Pille; Xue, Yali (2019). Evolutionary and functional analysis of RBMY1 gene copy number variation on the human Y chromosome. Human Molecular Genetics, 1−14.10.1093/hmg/ddz101 [ilmumas].
1.1.
2018
Shi, Wentao; Massaia, Andrea; Louzada, Sandra; Banerjee, Ruby; Hallast, Pille; Chen, Yuan; Bergström, Anders; Gu, Yong; Leonard, Steven; Quail, Michael A; Ayub, Qasim; Yang, Fengtang; Tyler-Smith, Chris; Xue, Yali (2018). Copy number variation arising from gene conversion on the human Y chromosome. Human Genetics, 137 (1), 73−83.10.1007/s00439-017-1857-9.
1.1.
2017
Maisano Delser, P.; Neumann, R.; Ballereau, S.; Hallast, P.; Batini, C.; Zadik, D.; Jobling, MA. (2017). Signatures of human European Palaeolithic expansion shown by resequencing of non-recombining X-chromosome segments. European Journal of Human Genetics, 25 (4), 485−492.10.1038/ejhg.2016.207.
1.1.
2017
Hallast, Pille; Jobling, Mark A. (2017). The Y chromosomes of the great apes. Human Genetics, 136 (5, 5), 511−528.10.1007/s00439-017-1769-8.
1.1.
2017
Batini, Chiara; Hallast, Pille; Vågene, Åshild J; Zadik, Daniel; Eriksen, Heidi A; Pamjav, Horolma; Sajantila, Antti; Wetton, Jon H; Jobling, Mark A (2017). Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. Scientific Reports, 7 (1), 12086−12086.10.1038/s41598-017-11307-9.
1.1.
2016
Hallast, Pille; Maisano Delser, Pierpaolo; Batini, Chiara; Zadik, Daniel; Rocchi, Mariano; Schempp, Werner; Tyler-Smith, Chris; Jobling, Mark A (2016). Great ape Y Chromosome and mitochondrial DNA phylogenies reflect subspecies structure and patterns of mating and dispersal. Genome Research, 26 (4), 427−439.10.1101/gr.198754.115.
1.1.
2016
de Manuel, Marc; Kuhlwilm, Martin; Frandsen, Peter; Sousa, Vitor C; Desai, Tariq; Prado-Martinez, Javier; Hernandez-Rodriguez, Jessica; Dupanloup, Isabelle; Lao, Oscar; Hallast, Pille; Schmidt, Joshua M; Heredia-Genestar, José María; Benazzo, Andrea; Barbujani, Guido; Peter, Benjamin M; Kuderna, Lukas F K; Casals, Ferran; Angedakin, Samuel; Arandjelovic, Mimi; Boesch, Christophe ... Marques-Bonet, Tomas (2016). Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science (New York, N.Y.), 354 (6311), 477−481.10.1126/science.aag2602.
1.1.
2016
Haber, Marc; Mezzavilla, Massimo; Bergström, Anders; Prado-Martinez, Javier; Hallast, Pille; Saif-Ali, Riyadh; Al-Habori, Molham; Dedoussis, George; Zeggini, Eleftheria; Blue-Smith, Jason; Wells, R Spencer; Xue, Yali; Zalloua, Pierre A; Tyler-Smith, Chris (2016). Chad Genetic Diversity Reveals an African History Marked by Multiple Holocene Eurasian Migrations. American Journal of Human Genetics, 99 (6), 1316−1324.10.1016/j.ajhg.2016.10.012.
1.1.
2015
Batini, Chiara; Hallast, Pille; Zadik, Daniel; Maisano Delser, Pierpaolo; Benazzo, Andrea; Ghirotto, Silvia; Arroyo-Pardo, Eduardo; Cavalleri, Gianpiero L.; de Knijff, Peter; Dupuy, Berit Myhre; Eriksen, Heidi A.; King, Turi E.; López de Munain, Adolfo; López-Parra, Ana M.; Loutradis, Aphrodite; Milasin, Jelena; Novelletto, Andrea; Pamjav, Horolma; Sajantila, Antti; Tolun, Aslıhan ... Jobling, Mark A. (2015). Large-scale recent expansion of European patrilineages shown by population resequencing. Nature Communications, 6 (7152), x−x.10.1038/ncomms8152.
1.1.
2015
Hallast, Pille; Batini, Chiara; Zadik, Daniel; Maisano Delser, Pierpaolo; Wetton, Jon H.; Arroyo-Pardo, Eduardo; Cavalleri, Gianpiero L.; de Knijff, Peter; Destro Bisol, Giovanni; Myhre Dupuy, Berit; Eriksen, Heidi A.; Jorde, Lynn B.; King, Turi E.; Larmuseau, Maarten H.; López de Munain, Adolfo; López-Parra, Ana M.; Loutradis, Aphrodite; Milasin, Jelena; Novelletto, Andrea; Pamjav, Horolma ... Jobling, Mark A. (2015). The Y-Chromosome Tree Bursts into Leaf: 13,000 High-Confidence SNPs Covering the Majority of Known Clades. Molecular Biology and Evolution, 32 (3), 661−673.10.1093/molbev/msu327.
5.2.
2015
Hallast, Pille; Maisano Delser, Pierpaolo; Batini, Chiara; Zadik, Daniel; Schempp, Werner; Rocchi, Mariano; Tyler-Smith, Chris; Jobling, Mark A. (2015). Great ape Y chromosome diversity reflects sub-species structure and sex-biased behaviours. Abstract book: The Biology of Genomes, Cold Spring Harbor, NY, USA, 05.05-09.05.2015; Society of Molecular Biology & Evolution (SMBE), Vienna, Austria, 12.-16. juuni 2015.
5.2.
2015
Batini, Chiara; Hallast, Pille; Zadik, Daniel; Maisano Delser, Pierpaolo; Benazzo, Andrea; Ghirotto, Silvia; Arroyo-Pardo, Eduardo; Cavalleri, Gianpiero L.; de Knijff, Peter; Dupuy, Berit Myhre; Eriksen, Heidi A.; King, Turi E.; López de Munain, Adolfo; López-Parra, Ana M.; Loutradis, Aphrodite; Milasin, Jelena; Novelletto, Andrea; Pamjav, Horolma; Sajantila, Antti; Tolun, Aslıhan ... Jobling, Mark A. (2015). Contrasting patterns in the high-resolution variation of uniparental markers in European populations highlight very recent male-specific expansions. Abstract books: The Biology of Genomes, Cold Spring Harbor, NY, USA, 05.05-09.05.2015; Society of Molecular Biology & Evolution (SMBE), Vienna, Austria, 12.-16. juuni 2015.
5.2.
2014
Batini, C.; Hallast, P.; Zadik, D.; Maisano Delser, P.; Wetton, JH.; Arroyo, E.; Bodmer, W.; Cavalleri, G.; de Knijff, P.; Destro Bisol, G.; Jobling, MA. (2014). Insights into the peopling of Europe through a high‐confidence Y‐chromosome phylogeny. Conference abstract book; abstract no 58: EMBO conference "Human evolution in the genomic era: Origins, populations and phenotypes", 1 – 4 April 2014, Leicester, UK.
5.2.
2014
Zadik, D.; Batini, C.; Hallast, P.; Maisano Delser, P.; Jobling, MA. (2014). Using cross‐species sequence‐capture and next‐generation sequencing to assess the role of gene conversion in the evolution of the human sex chromosomes. Conference abstract book; abstract no 76: EMBO conference "Human evolution in the genomic era: Origins, populations and phenotypes", 1 – 4 April 2014, Leicester, UK.
5.2.
2014
Maisano Delser, P.; Neumann, R.; Hallast, P.; Batini, C.; Lall, G.; Patel, S.; Zadik, D.; Ballereau, S.; Jobling, MA. (2014). Excavating European demographic history using NGS of X‐chromosomal haplotype blocks. Conference abstract book; abstract no 80: EMBO conference "Human evolution in the genomic era: Origins, populations and phenotypes", 1 – 4 April 2014, Leicester, UK.
1.1.
2013
Hallast, Pille; Balaresque, Patricia; Bowden, Georgina R; Ballereau, Stéphane; Jobling, Mark A (2013). Recombination Dynamics of a Human Y-Chromosomal Palindrome: Rapid GC-Biased Gene Conversion, Multi-kilobase Conversion Tracts, and Rare Inversions. Plos Genetics, 9 (7), e1003666.10.1371/journal.pgen.1003666.
5.2.
2012
Batini, Chiara; Zadik, Daniel; Hallast, Pille; Lall, Gurdeep; Jobling, Mark A (2012). Gene conversion and evolution of sex chromosomes: an NGS approach. Society of Molecular Biology & Evolution (SMBE), Dublin, Iirimaa, 23.-26. juuni 2012.
5.2.
2012
Maisano Delser, Pierpaolo; Hallast, Pille; Neumann, Rita; Ballereau, Stéphane; Jobling, Mark A (2012). X-chromosome haplotypes as markers for population historys. Society of Molecular Biology & Evolution (SMBE), Dublin, Iirimaa, 23.-26. juuni 2012.
5.2.
2012
Hallast, Pille; Bowden, Georgina; Balaresque, Patricia; Ballereau, Stéphane; Jobling, Mark A. (2012). Dynamics of intra-chromosomal recombination in human Y-chromosome palindrome P6. Society of Molecular Biology & Evolution (SMBE), Dublin, Iirimaa, 23.-26. juuni 2012.
1.1.
2011
Putku, M.; Kepp, K.; Org, E.; Sõber, S.; Comas, D.; Viigimaa, M.; Veldre, G.; Juhanson, P.; Hallast, P.; Tõnisson, N.; Shaw-Hawkins, S.; Caulfield, M.J.; Khusnutdinova, E.; Kožich, V.; Munroe, P.B.; Laan, M. (2011). Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans. Human Mutation, 32 (7), 806−814.10.1002/humu.21508.
5.2.
2011
Hallast, P.; Bowden, G.; Balaresque, P.; Ballereau, S.; Jobling, M.A. (2011). Dynamics of intrachromosomal recombination in human Y-chromosome palindrome P6. Abstract book: The Biology of Genomes, Cold Spring Harbor, NY, USA, 10.05-14.05.2011.
1.1.
2010
Nagirnaja, Liina; Rull, Kristiina; Uusküla, Liis; Hallast, Pille; Grigorova, Marina; Laan, Maris. (2010). Genomics and genetics of gonadotropin beta subunit genes: unique FSHB and duplicated LHB/CGB loci. Molecular and Cellular Endocrinology, 329, 4−16.10.1016/j.mce.2010.04.024.
5.2.
2010
Putku, M.; Kepp, K.; Org, E.; Sõber, S.; Comas, D.; Viigimaa, M.; Veldre, G.; Kelgo, P.; Hallast, P.; Tõnisson, N.; Juhanson, P.; Khusnutdinova, E.; Kožich, V.; Laan, M. (2010). Novel polymorphic AluYb8 insertion in WNK1 Gene associated with blood pressure regulation. Journal of Hypertension, 28: 20th Annual Meeting of the European-Society-of-Hypertension, Oslo, Norway, June 18-21, 2010. Lippincott Williams & Wilkins, E347−E348.
2.3.
2009
Hallast, P. (2009). Human and chimpanzee Luteinizing hormone/ Chorionic Gonadotropin beta (LHB/CGB) gene clusters: diversity and divergence of young duplicated genes. (Tartu Ülikool). Tartu: Tartu Ülikooli Kirjastus.
5.2.
2009
Rull, K.; Nagirnaja, L.; Hallast, P.; Uusküla, L.; Margus, T.; Kaare, M.; Ulander, V.-M.; Aittomäki, K.; Campbell, R. K.; Laan, M. (2009). Human chorionic gonadotropin and reproductive failure: genetic variation and disease-specific gene expression. Journal of developmental origins of health and disease, 1: 6th World Congress on Developmental Origins of Health and Disease; Santiago, Tšiili; 19.-22.11.2009. Cambridge University Press, S145.10.1017/S2040174409990067.
6.1.
2009
Hallast, P.; Laan, M. (2009). Evolution of the chorionic gonadotropin beta genes in primates. In: Encyclopedia of Life Science (ELS) (1−12).. Wiley-Blackwell.10.1002/9780470015902.a0021966.
1.1.
2008
Hallast, P.; Saarela, J.; Palotie, A.; Laan, M. (2008). High divergence in primate-specific duplicated regions: Human and chimpanzee Chorionic Gonadotropin Beta genes. BMC Evolutionary Biology, 8 (195), 1−14.10.1186/1471-2148-8-195.
1.1.
2008
Rull, K.; Hallast, P.; Uusküla, L.; Jackson, J.; Punab, M.; Salumets, A.; Campbell, R.; Laan, M. (2008). Fine scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. Molecular Human Reproduction, 14 (1), 23−31.10.1093/molehr/gam082.
5.1.
2008
Rull, K.; Nagirnaja, L.; Hallast, P.; Uusküla, L.; Ulander, VM.; Margus, T.; Kelgo, P.; Campbell, RC.; Aittomäki, K.; Laan, M. (2008). Expressional profile and genetic variation of chorionic gonadotropin beta genes is associated to recurrent miscarriages. Placenta, 29: IFPA2008/ 12th EPG conference, Seggau castle, Austria 10-13.09.2008. Elsevier, A46. (8).
5.2.
2008
Rull, K.; Nagirnaja, L.; Hallast, P.; Uusküla, L.; Kelgo, P.; Ulander, V.-M.; Aittomäki, K.; Campbell, R.C.; Laan, M. (2008). Human Chorionic Gonadotropin Beta genes: expression, genetic variation and reproductive failure. Abstract Book: 2nd International Conference on Gonadotropins and Their Receptors; Theobalds Park, Hertfordshire, UK; 6.07-9.07.2008.
5.2.
2008
Hallast, P.; Saarela, J.; Palotie, A.; Laan, M. (2008). Accelerated evolution of duplicated gene regions in human and chimpanzee: LHB/CGB gene family as an example. Abstract book: Genes at work on time, Toriino, Itaalia, 15.-18.10.2008.
5.2.
2008
Hallast, P.; Palotie, A.; Laan, M. (2008). The role of gene conversion in shaping the human and chimpanzee duplicated LHB/CGB gene cluster. Abstract Book: 2nd international Conference on Gonadotropins and Their Receptors; Theobalds Park, Hertfordshire, UK; 6.-9.07.2008.
1.1.
2007
Hallast, P.; Rull, K.; Laan, M. (2007). The evolution and genomic landscape of CGB1 and CGB2 genes. Molecular and Cellular Endocrinology, 260-262, 2−11.
5.2.
2007
Hallast, P.; Palotie, A; Laan, M. (2007). The role of gene conversion in shaping the human and chimpanzee duplicated LHB/CGB gene cluster. Abstract Book: The 9th International Meeting on Human Genome Variation and Complex Genome Analysis; Barcelona, Hispaania; 6.-8.09.2007.
5.2.
2007
Hallast, P.; Palotie, A.; Laan, M. (2007). Evolution by recent gene duplication: comparison of human and chimpanzee Luteinizing/ Chorionic Gonadotropin hormone beta subunit (LHB/CGB) gene cluster. Abstract Book: The Biology of Genomes; Cold Spring Harbor, USA; 8.05.-12.05.2007.
1.1.
2006
Koks, S.; Nikopensius, T.; Koido, K.; Maron, E.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Kurg, A.; Shlik, J.; Vasar, V.; Metspalu, A.; Vasar, E. (2006). Analysis of SNP profiles in patients with major depressive disorder. International Journal of Neuropsychopharmacology, 9 (2), 167−174.
5.2.
2006
Laan, M.; Hallast, P.; Grigorova, M.; Nagirnaja, L. (2006). Diversity patterns of gonadotropin hormone beta gene family: reflection of gene history, meiotic and evolutionary forces. Final programm and abstract book: 11th International Congress of Human Genetics; Brisbane, Australia; 6-10.08.2006. 193.
5.2.
2006
Hallast, P.; Laan, M. (2006). Comparison of CGB1, CGB2 and LHB genes in human and great apes. Abstract Book: The Human Genome Organisation (HUGO) 11th International Genome Meeting; Helsingi; 31.05-03.06.2006.
5.2.
2006
Laan, M.; Hallast, P.; Grigorova, M.;, Nagirnaja, L. (2006). Diversity patterns of gonadotropin hormone beta gene family: reflection of gene history, meiotic and evolutionary forces. Abstract Book: Human Genome Variation Society konverents “Copy number variation”; Helsingi; 31.05.2006.
1.1.
2005
Hallast, P.; Nagirnaja, L.; Margus, T.; Laan, M. (2005). Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin beta gene cluster. Genome Research, 15 (11), 1535−1546.
1.1.
2005
Maron, E.; Nikopensius, T.; Koks, S.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Koido, K.; Kurg, A.; Metspalu, A.; Vasar, E.; Vasar, V.; Shlik, J. (2005). Association study of 90 candidate gene polymorphisms in panic disorder. Psychiatric Genetics, 15 (1), 17−24.
1.1.
2005
Koido, K.; Kõks, S.; Nikopensius, T.; Maron, E.; Altmäe, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Kurg, A.; Shlik, J.; Vasar, V.; Metspalu, A.; Vasar, E. (2005). Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders. International Journal of Neuropsychopharmacology, 8 (2), 235−244.
5.1.
2005
Maron, E.; Koks, S.; Nikopensius, T.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Koido, K.; Kurg, A.; Shlik, J.; Vasar, V.; Metspalu, A.; Vasar, E. (2005). Association and haplotype analaysis of 90 single-nucleotide polymorphisms in mood disorders. European Neuropsychopharmacology, 15, S55−S56.
5.2.
2005
Hallast, P.; Laan, M. (2005). Role of gene conversion in shaping SNP and allelic association patterns of tandem duplicated genes: LHB/CGB gene cluster. Abstract book: International Conference on Gonadotropins and Receptors, Athens, GA, USA, 13.-17.04.2005.
5.1.
2004
Maron, E.; Nikopensius, T.; Koks, S.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Koido, K.; Kurg, A.; Metapalu, A.; Vasar, E.; Vasar, V.; Shlik, J. (2004). Association study of 90 candidate genetic polymorphisms in panic disorder: Positive findings with SNPs in serotonin, cholecystokinin and dopamine related genes. European Neuropsychopharmacology, 14, S317−S317.
5.2.
2004
Laan, M.; Hallast, P.; Grigorova, M. (2004). Allelic association and SNP patterns of tandemly duplicated LHB/CGB genes are potentially shaped by gene conversion. HGM 2004 Programme and Abstract book: HGM 2004: Human Genome meeting; Berlin, Saksamaa; 4 -7 Aprill 2004. 43−43.
5.1.
2002
Kurg, A.; Nikopensius, T.; Hallast, P.; Laan, M.; Koks, S.; Slik, J.; Maron, E.; Vasar, E.; Metspalu, A. (2002). Possible association of serotonin 1B receptor and cholecystolkinin 1 receptor gene polymorphisms in bipolar and unipolar affective disorder cases in Estonia. American Journal of Human Genetics, 71 (4), 484−484.
6.09.2019

Pille Hallast

https://www.etis.ee/CV/Pille_Hallast/eng
pille.hallast@ut.ee
http://

Qualifications

Academic degrees
Pille Hallast, Doctor's Degree, 2009, (sup) Maris Laan, Human and chimpanzee Luteinizing Hormone/ Chorionic Gonadotropin Beta (LHB/CGB) gene clusters: diversity and divergence of young duplicated genes, University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu.
Pille Hallast, Master's Degree, 2004, (sup) Maris Laan, Geenikonversiooni roll lokaalsete alleelse aheldatuse (LD) mustrite kujundamises inimese genoomis kooriongonadotropiini beta subühiku (CGB) geeniperekonna näitel (The role of gene conversion in shaping the local pattern of linkage disequilibrium in Human Chorionic gonadotropin b-subunit gene family), University of Tartu, Faculty of Biology and Geography.
 
 
Field of research
FIELD OF RESEARCH: 1. Biosciences and Environment; 1.3. Genetics

Publications

Category
Year
Publication
 
1.1.
2019
Shi, Wentao; Louzada, Sandra; Grigorova, Marina; Massaia, Andrea; Arciero, Elena; Kibena, Laura; Ge, Xiangyu Jack; Chen, Yuan; Ayub, Qasim; Poolamets, Olev; Tyler-Smith, Chris; Punab, Margus; Laan, Maris; Yang, Fengtang; Hallast, Pille; Xue, Yali (2019). Evolutionary and functional analysis of RBMY1 gene copy number variation on the human Y chromosome. Human Molecular Genetics, 1−14.10.1093/hmg/ddz101 [forthcoming].
1.1.
2018
Shi, Wentao; Massaia, Andrea; Louzada, Sandra; Banerjee, Ruby; Hallast, Pille; Chen, Yuan; Bergström, Anders; Gu, Yong; Leonard, Steven; Quail, Michael A; Ayub, Qasim; Yang, Fengtang; Tyler-Smith, Chris; Xue, Yali (2018). Copy number variation arising from gene conversion on the human Y chromosome. Human Genetics, 137 (1), 73−83.10.1007/s00439-017-1857-9.
1.1.
2017
Maisano Delser, P.; Neumann, R.; Ballereau, S.; Hallast, P.; Batini, C.; Zadik, D.; Jobling, MA. (2017). Signatures of human European Palaeolithic expansion shown by resequencing of non-recombining X-chromosome segments. European Journal of Human Genetics, 25 (4), 485−492.10.1038/ejhg.2016.207.
1.1.
2017
Hallast, Pille; Jobling, Mark A. (2017). The Y chromosomes of the great apes. Human Genetics, 136 (5, 5), 511−528.10.1007/s00439-017-1769-8.
1.1.
2017
Batini, Chiara; Hallast, Pille; Vågene, Åshild J; Zadik, Daniel; Eriksen, Heidi A; Pamjav, Horolma; Sajantila, Antti; Wetton, Jon H; Jobling, Mark A (2017). Population resequencing of European mitochondrial genomes highlights sex-bias in Bronze Age demographic expansions. Scientific Reports, 7 (1), 12086−12086.10.1038/s41598-017-11307-9.
1.1.
2016
Hallast, Pille; Maisano Delser, Pierpaolo; Batini, Chiara; Zadik, Daniel; Rocchi, Mariano; Schempp, Werner; Tyler-Smith, Chris; Jobling, Mark A (2016). Great ape Y Chromosome and mitochondrial DNA phylogenies reflect subspecies structure and patterns of mating and dispersal. Genome Research, 26 (4), 427−439.10.1101/gr.198754.115.
1.1.
2016
de Manuel, Marc; Kuhlwilm, Martin; Frandsen, Peter; Sousa, Vitor C; Desai, Tariq; Prado-Martinez, Javier; Hernandez-Rodriguez, Jessica; Dupanloup, Isabelle; Lao, Oscar; Hallast, Pille; Schmidt, Joshua M; Heredia-Genestar, José María; Benazzo, Andrea; Barbujani, Guido; Peter, Benjamin M; Kuderna, Lukas F K; Casals, Ferran; Angedakin, Samuel; Arandjelovic, Mimi; Boesch, Christophe ... Marques-Bonet, Tomas (2016). Chimpanzee genomic diversity reveals ancient admixture with bonobos. Science (New York, N.Y.), 354 (6311), 477−481.10.1126/science.aag2602.
1.1.
2016
Haber, Marc; Mezzavilla, Massimo; Bergström, Anders; Prado-Martinez, Javier; Hallast, Pille; Saif-Ali, Riyadh; Al-Habori, Molham; Dedoussis, George; Zeggini, Eleftheria; Blue-Smith, Jason; Wells, R Spencer; Xue, Yali; Zalloua, Pierre A; Tyler-Smith, Chris (2016). Chad Genetic Diversity Reveals an African History Marked by Multiple Holocene Eurasian Migrations. American Journal of Human Genetics, 99 (6), 1316−1324.10.1016/j.ajhg.2016.10.012.
1.1.
2015
Batini, Chiara; Hallast, Pille; Zadik, Daniel; Maisano Delser, Pierpaolo; Benazzo, Andrea; Ghirotto, Silvia; Arroyo-Pardo, Eduardo; Cavalleri, Gianpiero L.; de Knijff, Peter; Dupuy, Berit Myhre; Eriksen, Heidi A.; King, Turi E.; López de Munain, Adolfo; López-Parra, Ana M.; Loutradis, Aphrodite; Milasin, Jelena; Novelletto, Andrea; Pamjav, Horolma; Sajantila, Antti; Tolun, Aslıhan ... Jobling, Mark A. (2015). Large-scale recent expansion of European patrilineages shown by population resequencing. Nature Communications, 6 (7152), x−x.10.1038/ncomms8152.
1.1.
2015
Hallast, Pille; Batini, Chiara; Zadik, Daniel; Maisano Delser, Pierpaolo; Wetton, Jon H.; Arroyo-Pardo, Eduardo; Cavalleri, Gianpiero L.; de Knijff, Peter; Destro Bisol, Giovanni; Myhre Dupuy, Berit; Eriksen, Heidi A.; Jorde, Lynn B.; King, Turi E.; Larmuseau, Maarten H.; López de Munain, Adolfo; López-Parra, Ana M.; Loutradis, Aphrodite; Milasin, Jelena; Novelletto, Andrea; Pamjav, Horolma ... Jobling, Mark A. (2015). The Y-Chromosome Tree Bursts into Leaf: 13,000 High-Confidence SNPs Covering the Majority of Known Clades. Molecular Biology and Evolution, 32 (3), 661−673.10.1093/molbev/msu327.
5.2.
2015
Hallast, Pille; Maisano Delser, Pierpaolo; Batini, Chiara; Zadik, Daniel; Schempp, Werner; Rocchi, Mariano; Tyler-Smith, Chris; Jobling, Mark A. (2015). Great ape Y chromosome diversity reflects sub-species structure and sex-biased behaviours. Abstract book: The Biology of Genomes, Cold Spring Harbor, NY, USA, 05.05-09.05.2015; Society of Molecular Biology & Evolution (SMBE), Vienna, Austria, 12.-16. juuni 2015.
5.2.
2015
Batini, Chiara; Hallast, Pille; Zadik, Daniel; Maisano Delser, Pierpaolo; Benazzo, Andrea; Ghirotto, Silvia; Arroyo-Pardo, Eduardo; Cavalleri, Gianpiero L.; de Knijff, Peter; Dupuy, Berit Myhre; Eriksen, Heidi A.; King, Turi E.; López de Munain, Adolfo; López-Parra, Ana M.; Loutradis, Aphrodite; Milasin, Jelena; Novelletto, Andrea; Pamjav, Horolma; Sajantila, Antti; Tolun, Aslıhan ... Jobling, Mark A. (2015). Contrasting patterns in the high-resolution variation of uniparental markers in European populations highlight very recent male-specific expansions. Abstract books: The Biology of Genomes, Cold Spring Harbor, NY, USA, 05.05-09.05.2015; Society of Molecular Biology & Evolution (SMBE), Vienna, Austria, 12.-16. juuni 2015.
5.2.
2014
Batini, C.; Hallast, P.; Zadik, D.; Maisano Delser, P.; Wetton, JH.; Arroyo, E.; Bodmer, W.; Cavalleri, G.; de Knijff, P.; Destro Bisol, G.; Jobling, MA. (2014). Insights into the peopling of Europe through a high‐confidence Y‐chromosome phylogeny. Conference abstract book; abstract no 58: EMBO conference "Human evolution in the genomic era: Origins, populations and phenotypes", 1 – 4 April 2014, Leicester, UK.
5.2.
2014
Zadik, D.; Batini, C.; Hallast, P.; Maisano Delser, P.; Jobling, MA. (2014). Using cross‐species sequence‐capture and next‐generation sequencing to assess the role of gene conversion in the evolution of the human sex chromosomes. Conference abstract book; abstract no 76: EMBO conference "Human evolution in the genomic era: Origins, populations and phenotypes", 1 – 4 April 2014, Leicester, UK.
5.2.
2014
Maisano Delser, P.; Neumann, R.; Hallast, P.; Batini, C.; Lall, G.; Patel, S.; Zadik, D.; Ballereau, S.; Jobling, MA. (2014). Excavating European demographic history using NGS of X‐chromosomal haplotype blocks. Conference abstract book; abstract no 80: EMBO conference "Human evolution in the genomic era: Origins, populations and phenotypes", 1 – 4 April 2014, Leicester, UK.
1.1.
2013
Hallast, Pille; Balaresque, Patricia; Bowden, Georgina R; Ballereau, Stéphane; Jobling, Mark A (2013). Recombination Dynamics of a Human Y-Chromosomal Palindrome: Rapid GC-Biased Gene Conversion, Multi-kilobase Conversion Tracts, and Rare Inversions. Plos Genetics, 9 (7), e1003666.10.1371/journal.pgen.1003666.
5.2.
2012
Batini, Chiara; Zadik, Daniel; Hallast, Pille; Lall, Gurdeep; Jobling, Mark A (2012). Gene conversion and evolution of sex chromosomes: an NGS approach. Society of Molecular Biology & Evolution (SMBE), Dublin, Iirimaa, 23.-26. juuni 2012.
5.2.
2012
Maisano Delser, Pierpaolo; Hallast, Pille; Neumann, Rita; Ballereau, Stéphane; Jobling, Mark A (2012). X-chromosome haplotypes as markers for population historys. Society of Molecular Biology & Evolution (SMBE), Dublin, Iirimaa, 23.-26. juuni 2012.
5.2.
2012
Hallast, Pille; Bowden, Georgina; Balaresque, Patricia; Ballereau, Stéphane; Jobling, Mark A. (2012). Dynamics of intra-chromosomal recombination in human Y-chromosome palindrome P6. Society of Molecular Biology & Evolution (SMBE), Dublin, Iirimaa, 23.-26. juuni 2012.
1.1.
2011
Putku, M.; Kepp, K.; Org, E.; Sõber, S.; Comas, D.; Viigimaa, M.; Veldre, G.; Juhanson, P.; Hallast, P.; Tõnisson, N.; Shaw-Hawkins, S.; Caulfield, M.J.; Khusnutdinova, E.; Kožich, V.; Munroe, P.B.; Laan, M. (2011). Novel polymorphic AluYb8 insertion in the WNK1 gene is associated with blood pressure variation in Europeans. Human Mutation, 32 (7), 806−814.10.1002/humu.21508.
5.2.
2011
Hallast, P.; Bowden, G.; Balaresque, P.; Ballereau, S.; Jobling, M.A. (2011). Dynamics of intrachromosomal recombination in human Y-chromosome palindrome P6. Abstract book: The Biology of Genomes, Cold Spring Harbor, NY, USA, 10.05-14.05.2011.
1.1.
2010
Nagirnaja, Liina; Rull, Kristiina; Uusküla, Liis; Hallast, Pille; Grigorova, Marina; Laan, Maris. (2010). Genomics and genetics of gonadotropin beta subunit genes: unique FSHB and duplicated LHB/CGB loci. Molecular and Cellular Endocrinology, 329, 4−16.10.1016/j.mce.2010.04.024.
5.2.
2010
Putku, M.; Kepp, K.; Org, E.; Sõber, S.; Comas, D.; Viigimaa, M.; Veldre, G.; Kelgo, P.; Hallast, P.; Tõnisson, N.; Juhanson, P.; Khusnutdinova, E.; Kožich, V.; Laan, M. (2010). Novel polymorphic AluYb8 insertion in WNK1 Gene associated with blood pressure regulation. Journal of Hypertension, 28: 20th Annual Meeting of the European-Society-of-Hypertension, Oslo, Norway, June 18-21, 2010. Lippincott Williams & Wilkins, E347−E348.
2.3.
2009
Hallast, P. (2009). Human and chimpanzee Luteinizing hormone/ Chorionic Gonadotropin beta (LHB/CGB) gene clusters: diversity and divergence of young duplicated genes. (Tartu Ülikool). Tartu: Tartu Ülikooli Kirjastus.
5.2.
2009
Rull, K.; Nagirnaja, L.; Hallast, P.; Uusküla, L.; Margus, T.; Kaare, M.; Ulander, V.-M.; Aittomäki, K.; Campbell, R. K.; Laan, M. (2009). Human chorionic gonadotropin and reproductive failure: genetic variation and disease-specific gene expression. Journal of developmental origins of health and disease, 1: 6th World Congress on Developmental Origins of Health and Disease; Santiago, Tšiili; 19.-22.11.2009. Cambridge University Press, S145.10.1017/S2040174409990067.
6.1.
2009
Hallast, P.; Laan, M. (2009). Evolution of the chorionic gonadotropin beta genes in primates. In: Encyclopedia of Life Science (ELS) (1−12).. Wiley-Blackwell.10.1002/9780470015902.a0021966.
1.1.
2008
Hallast, P.; Saarela, J.; Palotie, A.; Laan, M. (2008). High divergence in primate-specific duplicated regions: Human and chimpanzee Chorionic Gonadotropin Beta genes. BMC Evolutionary Biology, 8 (195), 1−14.10.1186/1471-2148-8-195.
1.1.
2008
Rull, K.; Hallast, P.; Uusküla, L.; Jackson, J.; Punab, M.; Salumets, A.; Campbell, R.; Laan, M. (2008). Fine scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. Molecular Human Reproduction, 14 (1), 23−31.10.1093/molehr/gam082.
5.1.
2008
Rull, K.; Nagirnaja, L.; Hallast, P.; Uusküla, L.; Ulander, VM.; Margus, T.; Kelgo, P.; Campbell, RC.; Aittomäki, K.; Laan, M. (2008). Expressional profile and genetic variation of chorionic gonadotropin beta genes is associated to recurrent miscarriages. Placenta, 29: IFPA2008/ 12th EPG conference, Seggau castle, Austria 10-13.09.2008. Elsevier, A46. (8).
5.2.
2008
Rull, K.; Nagirnaja, L.; Hallast, P.; Uusküla, L.; Kelgo, P.; Ulander, V.-M.; Aittomäki, K.; Campbell, R.C.; Laan, M. (2008). Human Chorionic Gonadotropin Beta genes: expression, genetic variation and reproductive failure. Abstract Book: 2nd International Conference on Gonadotropins and Their Receptors; Theobalds Park, Hertfordshire, UK; 6.07-9.07.2008.
5.2.
2008
Hallast, P.; Saarela, J.; Palotie, A.; Laan, M. (2008). Accelerated evolution of duplicated gene regions in human and chimpanzee: LHB/CGB gene family as an example. Abstract book: Genes at work on time, Toriino, Itaalia, 15.-18.10.2008.
5.2.
2008
Hallast, P.; Palotie, A.; Laan, M. (2008). The role of gene conversion in shaping the human and chimpanzee duplicated LHB/CGB gene cluster. Abstract Book: 2nd international Conference on Gonadotropins and Their Receptors; Theobalds Park, Hertfordshire, UK; 6.-9.07.2008.
1.1.
2007
Hallast, P.; Rull, K.; Laan, M. (2007). The evolution and genomic landscape of CGB1 and CGB2 genes. Molecular and Cellular Endocrinology, 260-262, 2−11.
5.2.
2007
Hallast, P.; Palotie, A; Laan, M. (2007). The role of gene conversion in shaping the human and chimpanzee duplicated LHB/CGB gene cluster. Abstract Book: The 9th International Meeting on Human Genome Variation and Complex Genome Analysis; Barcelona, Hispaania; 6.-8.09.2007.
5.2.
2007
Hallast, P.; Palotie, A.; Laan, M. (2007). Evolution by recent gene duplication: comparison of human and chimpanzee Luteinizing/ Chorionic Gonadotropin hormone beta subunit (LHB/CGB) gene cluster. Abstract Book: The Biology of Genomes; Cold Spring Harbor, USA; 8.05.-12.05.2007.
1.1.
2006
Koks, S.; Nikopensius, T.; Koido, K.; Maron, E.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Kurg, A.; Shlik, J.; Vasar, V.; Metspalu, A.; Vasar, E. (2006). Analysis of SNP profiles in patients with major depressive disorder. International Journal of Neuropsychopharmacology, 9 (2), 167−174.
5.2.
2006
Laan, M.; Hallast, P.; Grigorova, M.; Nagirnaja, L. (2006). Diversity patterns of gonadotropin hormone beta gene family: reflection of gene history, meiotic and evolutionary forces. Final programm and abstract book: 11th International Congress of Human Genetics; Brisbane, Australia; 6-10.08.2006. 193.
5.2.
2006
Hallast, P.; Laan, M. (2006). Comparison of CGB1, CGB2 and LHB genes in human and great apes. Abstract Book: The Human Genome Organisation (HUGO) 11th International Genome Meeting; Helsingi; 31.05-03.06.2006.
5.2.
2006
Laan, M.; Hallast, P.; Grigorova, M.;, Nagirnaja, L. (2006). Diversity patterns of gonadotropin hormone beta gene family: reflection of gene history, meiotic and evolutionary forces. Abstract Book: Human Genome Variation Society konverents “Copy number variation”; Helsingi; 31.05.2006.
1.1.
2005
Hallast, P.; Nagirnaja, L.; Margus, T.; Laan, M. (2005). Segmental duplications and gene conversion: Human luteinizing hormone/chorionic gonadotropin beta gene cluster. Genome Research, 15 (11), 1535−1546.
1.1.
2005
Maron, E.; Nikopensius, T.; Koks, S.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Koido, K.; Kurg, A.; Metspalu, A.; Vasar, E.; Vasar, V.; Shlik, J. (2005). Association study of 90 candidate gene polymorphisms in panic disorder. Psychiatric Genetics, 15 (1), 17−24.
1.1.
2005
Koido, K.; Kõks, S.; Nikopensius, T.; Maron, E.; Altmäe, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Kurg, A.; Shlik, J.; Vasar, V.; Metspalu, A.; Vasar, E. (2005). Polymorphisms in wolframin (WFS1) gene are possibly related to increased risk for mood disorders. International Journal of Neuropsychopharmacology, 8 (2), 235−244.
5.1.
2005
Maron, E.; Koks, S.; Nikopensius, T.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Koido, K.; Kurg, A.; Shlik, J.; Vasar, V.; Metspalu, A.; Vasar, E. (2005). Association and haplotype analaysis of 90 single-nucleotide polymorphisms in mood disorders. European Neuropsychopharmacology, 15, S55−S56.
5.2.
2005
Hallast, P.; Laan, M. (2005). Role of gene conversion in shaping SNP and allelic association patterns of tandem duplicated genes: LHB/CGB gene cluster. Abstract book: International Conference on Gonadotropins and Receptors, Athens, GA, USA, 13.-17.04.2005.
5.1.
2004
Maron, E.; Nikopensius, T.; Koks, S.; Altmae, S.; Heinaste, E.; Vabrit, K.; Tammekivi, V.; Hallast, P.; Koido, K.; Kurg, A.; Metapalu, A.; Vasar, E.; Vasar, V.; Shlik, J. (2004). Association study of 90 candidate genetic polymorphisms in panic disorder: Positive findings with SNPs in serotonin, cholecystokinin and dopamine related genes. European Neuropsychopharmacology, 14, S317−S317.
5.2.
2004
Laan, M.; Hallast, P.; Grigorova, M. (2004). Allelic association and SNP patterns of tandemly duplicated LHB/CGB genes are potentially shaped by gene conversion. HGM 2004 Programme and Abstract book: HGM 2004: Human Genome meeting; Berlin, Saksamaa; 4 -7 Aprill 2004. 43−43.
5.1.
2002
Kurg, A.; Nikopensius, T.; Hallast, P.; Laan, M.; Koks, S.; Slik, J.; Maron, E.; Vasar, E.; Metspalu, A. (2002). Possible association of serotonin 1B receptor and cholecystolkinin 1 receptor gene polymorphisms in bipolar and unipolar affective disorder cases in Estonia. American Journal of Human Genetics, 71 (4), 484−484.
6.09.2019
Detailne otsing
  • Leitud 8 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
PUT; PUT_SPPUT1036Dünaamilised sugu-kromosoomid ja meeste viljatus: uue-generatsiooni lähenemine01.01.201605.06.2021Pille HallastTartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut; Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut133 200,00 EUR
MUULSSG-CT-2006-037654Funktsionaalse genoomika ajaline dimensioon (PROUST)01.01.200728.02.2009Maris LaanEesti Biokeskus50 331,32 EUR
SFSF0182721s06Genoomi ülesehitus ja varieeruvus: evolutsiooni- ja rekombinatsiooni protsesside peegeldus ning seos normaalse ja patoloogilise funktsiooniga01.01.200631.12.2011Maris LaanTartu Ülikool, Bioloogia-geograafiateaduskond; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond418 383,64 EUR
SFSF0182582As03Inimese Genoom II01.01.200331.12.2007Andres MetspaluTartu Ülikool, Bioloogia-geograafiateaduskond328 505,88 EUR
ETFETF7471INIMESE KASVUHORMOONI/ KOORIONI SOMATOMAMMOTROPIINI GENOOMI KLASTER: varieeruvuse ja ekspressiooni seos üsasisese kasvu, loote-ema metabolismi ja soodumusega kardiovaskulaarhaigustele täiskasvanueas. 01.01.200831.12.2011Maris LaanTartu Ülikool, Bioloogia-geograafiateaduskond; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut; Tartu Ülikool, Loodus- ja tehnoloogiateaduskond119 028,97 EUR
ETFETF5796Inimese lutropiini/kooriongonadotropiini ß-subühiku genoomiklaster (I) Genoomne varieeruvus, LD struktuur ning mittehomoloogilise ristsiirde ja geenikonversiooni roll nende kujundamisel.01.01.200431.12.2007Maris LaanTartu Ülikool, Bioloogia-geograafiateaduskond54 007,15 EUR
SFSF0180022s12Inimese reproduktiiv- ja metaboolne funktsioon: genoomi ekspressioon, varieeruvus ja pleiotroopsed effektid01.01.201231.12.2014Maris LaanTartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut374 340,00 EUR
IUTIUT34-12Inimese reproduktiivset edukust määravad geneetilised ja molekulaarsed tegurid01.01.201531.12.2020Maris LaanTartu Ülikool, Loodus- ja täppisteaduste valdkond, molekulaar- ja rakubioloogia instituut; Tartu Ülikool, Meditsiiniteaduste valdkond, bio- ja siirdemeditsiini instituut704 000,00 EUR