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Olen nõus

Illar Pata

https://www.etis.ee/CV/Illar_Pata/est
4.07.1967
+372-6204443
+372-56677295
illar.pata@gmail.com

Teenistuskäik

Töökohad ja ametid
1997: EMBO stipendium F. Grosveldi laboris (Rotterdami Erasmuse Ülikool);
1997-99: külalisteadur H. Sariola laboris (Helsingi Ülikool);
2003-04: teadur R. Allikmetsa laboris (Columbia Ülikool, New York).
2009–2014   
Vähiuuringute Tehnoloogia Arenduskeskus AS, Teadur (0,50)
2005–31.12.2009   
Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut, Molekulaardiagnostika õppetool, erakorraline vanemteadur (1,00)
 
 
Haridustee
Tartu Ülikool, bioloogia 1991

Kvalifikatsioon

Teaduskraadid
Illar Pata, doktorikraad, 1996, (juh) Andres Metspalu, Cloning and characterization of human and mouse ribosomal protein S6-encoding genes, Tartu Ülikool, Loodus- ja tehnoloogiateaduskond, Tartu Ülikooli Molekulaar- ja Rakubioloogia Instituut, Biotehnoloogia õppetool.
 
 
Teadustöö põhisuunad
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; TÄPSUSTUS: Hh-Gli signaalirada organismi normaalses arengus ja vähi patoloogias
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; TÄPSUSTUS: Vähiteraapia vektorite arendamine
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS KLASSIFIKAATOR: B220 Geneetika, tsütogeneetika ; TÄPSUSTUS: Arengubioloogia, konditsionaalsed hiiremudelid.
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS KLASSIFIKAATOR: T490 Biotehnoloogia ; TÄPSUSTUS: Industeeritavad lentiviirusvektorid.
ETIS KLASSIFIKAATOR: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS KLASSIFIKAATOR: T490 Biotehnoloogia ; TÄPSUSTUS: Haigusmudelite eluskuvamist võimaldavate reporteritre arendamine: indutseeritavad lutsiferaasid ja fluorestseeruvad kaugpunavalgud.

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2018
Kovacovicova, K.; Skolnaja, M.; Heinmaa, M.; Mistrik, M.; Pata, P.; Pata, I.; Bartek, J.; Vinciguerra, M. (2018). Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer. Frontiers in Oncology.10.3389/fonc.2018.00459.
1.1.
2018
Teras, Marina; Viisileht, Edda; Pahtma-Hall, Merlis; Rump, Airi; Paalme, Viiu; Pata, Pille; Pata, Illar; Langevin, Christelle; Boudinot, Sirje Ruutel (2018). Porcine circovirus type 2 ORF3 protein induces apoptosis in melanoma cells. BMC Cancer, 18, ARTN 1237.10.1186/s12885-018-5090-2.
5.2.
2018
Silm, E.; Pata, P.; Kruis, J. C.; Sikerina, A.; Pata, I.; Kanger, T.; Gathergood, N. (2018). Catalysts derived from sustainable natural and value added alkaloids from poppies. IUPAC Postgraduate Summer School on Green Chemistry 7-14 July 2018 Venice, Italy. IUPAC , 24.
5.2.
2018
Silm, E.; Pata,P.; Kruis, J. C.; Sikerina, A.; Pata, I.; Kanger, T.; Gathergood, N. (2018). Catalysts derived from sustainable natural and value added alkaloids from poppies. 3rd Green and Sustainable Chemistry Conference, Berlin, 13-16th May 2018. Elsevier, p1.29.
1.1.
2017
Panebianco, C.; Kelman, E.; Vene, K.; Gioffreda, D.; Tavano, F.; Vilu, R.; Terracciano, F.; Pata, I.; Adamberg, K.; Andriulli, A.; Pazienza, V. (2017). Cancer sniffer dogs: how can we translate this peculiarity in the laboratory medicine? Results of a pilot study on gastrointestinal cancers. Clinical Chemistry and Laboratory Medicine, 36 (1), 138−146.10.1515/cclm-2016-1158.
1.1.
2017
Oriana Lo Re, Caterina Fusilli, Francesca Rappa, Matthias Van Haele, Julien Douet, Jana Pindjakova, Sura Wanessa Rocha, Illar Pata, Barbora Valčíková, Stjepan Uldrijan, Raymond S. Yeung, Christina Alves Peixoto, Tania Roskams, Marcus Buschbeck, Tommaso Mazza, Manlio Vinciguerra (2017). Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma. Hepatology, 67 (2), 636−650.10.1002/hep.29519.
5.2.
2017
Silm, E.; Pata, P.; Kruis, J. C.; Sikerina, A.; Pata, I.; Kanger, T.; Gathergood, N. (2017). Catalysts derived from sustainable natural and value added alkaloids from poppies. 20th European Symposium on Organic Chemistry 2-6 July 2017 Cologne, Germany. Universität zu Köln,.
1.1.
2016
Borghesan, M.; Fusilli, C.; Rappa, F.; Panebianco, C.; Rizzo, G.; Oben, J. A; Mazzoccoli, G.; Faulkes, C.; Pata, I.; Agodi, A.; Rezaee, F.; Minogue, S.; Warren, A.; Peterson, A.; Sedivy, J. M; Douet, J.; Buschbeck, M.; Cappello, F.; Mazza, T.; Pazienza, V. ... Vinciguerra, M. (2016). DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Cancer research, Jan 15.10.1158/0008-5472.CAN-15-1336.
1.1.
2016
Jueliger, Simone; Lyons, John; Cannito, Sara; Pata, Illar; Pata, Pille; Shkolnaya, Marianna; Lo Re, Oriana; Peyrou, Marion; Villarroya, Francesc; Pazienza, Valerio; Rappa, Francesca; Cappello, Francesco; Azab, Mohammad; Taverna, Pietro; Vinciguerra, Manlio (2016). Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma. Epigenetics, 11 (10), 709−720.10.1080/15592294.2016.1214781.
1.1.
2015
Luker, K. E.; Pata, P.; Shemiakina, I. I.; Pereverzeva, A.; Stacer, A. C.; Shcherbo, D. S.; Pletnev, V. Z.; Skolnaja, M.; Lukyanov, K. A.; Luker, G. D.; Pata, I.; Chudakov, D. M. (2015). Comparative study reveals better far-red fluorescent protein for whole body imaging. Scientific Reports, 5, ARTN 10332.10.1038/srep10332.
5.1.
2015
Vinciguerra, M.; Borghesan, M.; Rappa, F.; Panebianco, C.; Cappello, F.; Pata, I.; Buschbeck, M.; Sedivy, J.; Fusilli, C.; Mazza, T.; Pazienza, V. (2015). Histone Variant MacroH2A1 Marks Liver Aging and Orchestrates the Escape from Senescence Induced by DNA Hypomethylation in Hepatocellular Carcinoma. FASEB J, 29. FASEB Publications, LB445.
5.2.
2010
K. Kärblane, P. Pata, I. Pata, E. Truve and C. Sarmiento (2010). RNA silencing suppressors of plant viral and endogenous origin expressed in mammalian cells. Keystone Symposia "RNA silencing Mechanisms in Plants"; M. A. Matzke and J. C. Carrington; Feb 21-26, 2010; Santa Fe, New Mexico, USA. 87.
1.1.
2008
Kong, J; Kim, S.R.; Binley, K.; Pata, I.; Doi, K.; Mannik, J.; Zernant-Rajang, J.; Kan, O.; Iqball, S. et al. (2008). Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy. Gene Therapy, 15, 1311−1320.10.1038/gt.2008.78.
1.1.
2008
Kala, K; Jukkola, T; Pata, I; Partanen, J. (2008). Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain. Genesis, 46 (1), 29−36.
1.1.
2006
Speek M, Njunkova O, Pata I, Valdre E, Kogerman P. (2006). A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. BMC Molecular Biology, 7 (13), 1−13.10.1186/1471-2199-7-13.
1.1.
2001
Meng, XJ.; Pata, I.; Pedrono, E.; Popsueva, A.; de Rooij, DG.; Janne, M.; Rauvala, H.; Sariola, H. (2001). Transient disruption of spermatogenesis by deregulated expression of neurturin in testis. Molecular and Cellular Endocrinology, 184, 33−39.
1.1.
2001
Krinka, D.; Raid, R.; Pata, I.; Karner, J.; Maimets, T. (2001). In situ hybridisation of chick embryos with p53-specific probe and their immunostaining with anti-p53 antibodies. Anatomy and Embryology, 204 (3), 207−215.
1.1.
2001
Karis, A.; Pata, I.; van Doorninck, JH.; Grosveld, F.; de Zeeuw, CI.; de Caprona, D.; Fritzsch, B. (2001). Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. Journal of Comparative Neurology, 429 (4), 615−630.

Tööstusomand

4.03.2020

Illar Pata

https://www.etis.ee/CV/Illar_Pata/eng
4.07.1967
+372-6204443
+372-56677295
illar.pata@gmail.com

Career

Institutions and positions
1997: EMBO fellowship at Frank Grosveld's lab (Erasmus University Rotterdam, Netherlands);
1997-99: visiting research fellow at Hannu Sariola’s lab (University of Helsinki, Finland);
2003-04: postdoctoral research scientist at Rando Allikmets’ lab (Columbia University, New York).
2009–2014   
Competence Center for Cancer Research, Researcher (0,50)
2005–31.12.2009   
Tallinn University of Technology , Faculty of Science, Department of Gene Technology, Chair of Molecular Diagnostics, Extraordinary Senior Researcher (1,00)
 
 
Education
University of Tartu, biology

Qualifications

Academic degrees
Illar Pata, Doctor's Degree, 1996, (sup) Andres Metspalu, Cloning and characterization of human and mouse ribosomal protein S6-encoding genes (Cloning and characterization of human and mouse ribosomal protein S6-encoding genes), University of Tartu, Faculty of Science and Technology (old), Institute of Molecular and Cell Biology, University of Tartu, Chair of Biotechnology.
 
 
Fields of research
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; SPECIFICATION: Hedgehog signalling in normal development and cancer
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; SPECIFICATION: Design and development of vectors for therapy of cancer
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS CLASSIFICATION: B220 Genetics, cytogenetics ; SPECIFICATION: Developmental biology, Conditional mouse models.
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS CLASSIFICATION: T490 Biotechnology ; SPECIFICATION: Inducible lentiviral vectors.
ETIS CLASSIFICATION: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS CLASSIFICATION: T490 Biotechnology ; SPECIFICATION: Development of reporter systems for in vivo imaging of disease models: inducible luciferases and near-infrared fluorescent proteins.
 
 

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2018
Kovacovicova, K.; Skolnaja, M.; Heinmaa, M.; Mistrik, M.; Pata, P.; Pata, I.; Bartek, J.; Vinciguerra, M. (2018). Senolytic Cocktail Dasatinib+Quercetin (D+Q) Does Not Enhance the Efficacy of Senescence-Inducing Chemotherapy in Liver Cancer. Frontiers in Oncology.10.3389/fonc.2018.00459.
1.1.
2018
Teras, Marina; Viisileht, Edda; Pahtma-Hall, Merlis; Rump, Airi; Paalme, Viiu; Pata, Pille; Pata, Illar; Langevin, Christelle; Boudinot, Sirje Ruutel (2018). Porcine circovirus type 2 ORF3 protein induces apoptosis in melanoma cells. BMC Cancer, 18, ARTN 1237.10.1186/s12885-018-5090-2.
5.2.
2018
Silm, E.; Pata, P.; Kruis, J. C.; Sikerina, A.; Pata, I.; Kanger, T.; Gathergood, N. (2018). Catalysts derived from sustainable natural and value added alkaloids from poppies. IUPAC Postgraduate Summer School on Green Chemistry 7-14 July 2018 Venice, Italy. IUPAC , 24.
5.2.
2018
Silm, E.; Pata,P.; Kruis, J. C.; Sikerina, A.; Pata, I.; Kanger, T.; Gathergood, N. (2018). Catalysts derived from sustainable natural and value added alkaloids from poppies. 3rd Green and Sustainable Chemistry Conference, Berlin, 13-16th May 2018. Elsevier, p1.29.
1.1.
2017
Panebianco, C.; Kelman, E.; Vene, K.; Gioffreda, D.; Tavano, F.; Vilu, R.; Terracciano, F.; Pata, I.; Adamberg, K.; Andriulli, A.; Pazienza, V. (2017). Cancer sniffer dogs: how can we translate this peculiarity in the laboratory medicine? Results of a pilot study on gastrointestinal cancers. Clinical Chemistry and Laboratory Medicine, 36 (1), 138−146.10.1515/cclm-2016-1158.
1.1.
2017
Oriana Lo Re, Caterina Fusilli, Francesca Rappa, Matthias Van Haele, Julien Douet, Jana Pindjakova, Sura Wanessa Rocha, Illar Pata, Barbora Valčíková, Stjepan Uldrijan, Raymond S. Yeung, Christina Alves Peixoto, Tania Roskams, Marcus Buschbeck, Tommaso Mazza, Manlio Vinciguerra (2017). Induction of cancer cell stemness by depletion of macrohistone H2A1 in hepatocellular carcinoma. Hepatology, 67 (2), 636−650.10.1002/hep.29519.
5.2.
2017
Silm, E.; Pata, P.; Kruis, J. C.; Sikerina, A.; Pata, I.; Kanger, T.; Gathergood, N. (2017). Catalysts derived from sustainable natural and value added alkaloids from poppies. 20th European Symposium on Organic Chemistry 2-6 July 2017 Cologne, Germany. Universität zu Köln,.
1.1.
2016
Borghesan, M.; Fusilli, C.; Rappa, F.; Panebianco, C.; Rizzo, G.; Oben, J. A; Mazzoccoli, G.; Faulkes, C.; Pata, I.; Agodi, A.; Rezaee, F.; Minogue, S.; Warren, A.; Peterson, A.; Sedivy, J. M; Douet, J.; Buschbeck, M.; Cappello, F.; Mazza, T.; Pazienza, V. ... Vinciguerra, M. (2016). DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression. Cancer research, Jan 15.10.1158/0008-5472.CAN-15-1336.
1.1.
2016
Jueliger, Simone; Lyons, John; Cannito, Sara; Pata, Illar; Pata, Pille; Shkolnaya, Marianna; Lo Re, Oriana; Peyrou, Marion; Villarroya, Francesc; Pazienza, Valerio; Rappa, Francesca; Cappello, Francesco; Azab, Mohammad; Taverna, Pietro; Vinciguerra, Manlio (2016). Efficacy and epigenetic interactions of novel DNA hypomethylating agent guadecitabine (SGI-110) in preclinical models of hepatocellular carcinoma. Epigenetics, 11 (10), 709−720.10.1080/15592294.2016.1214781.
1.1.
2015
Luker, K. E.; Pata, P.; Shemiakina, I. I.; Pereverzeva, A.; Stacer, A. C.; Shcherbo, D. S.; Pletnev, V. Z.; Skolnaja, M.; Lukyanov, K. A.; Luker, G. D.; Pata, I.; Chudakov, D. M. (2015). Comparative study reveals better far-red fluorescent protein for whole body imaging. Scientific Reports, 5, ARTN 10332.10.1038/srep10332.
5.1.
2015
Vinciguerra, M.; Borghesan, M.; Rappa, F.; Panebianco, C.; Cappello, F.; Pata, I.; Buschbeck, M.; Sedivy, J.; Fusilli, C.; Mazza, T.; Pazienza, V. (2015). Histone Variant MacroH2A1 Marks Liver Aging and Orchestrates the Escape from Senescence Induced by DNA Hypomethylation in Hepatocellular Carcinoma. FASEB J, 29. FASEB Publications, LB445.
5.2.
2010
K. Kärblane, P. Pata, I. Pata, E. Truve and C. Sarmiento (2010). RNA silencing suppressors of plant viral and endogenous origin expressed in mammalian cells. Keystone Symposia "RNA silencing Mechanisms in Plants"; M. A. Matzke and J. C. Carrington; Feb 21-26, 2010; Santa Fe, New Mexico, USA. 87.
1.1.
2008
Kong, J; Kim, S.R.; Binley, K.; Pata, I.; Doi, K.; Mannik, J.; Zernant-Rajang, J.; Kan, O.; Iqball, S. et al. (2008). Correction of the disease phenotype in the mouse model of Stargardt disease by lentiviral gene therapy. Gene Therapy, 15, 1311−1320.10.1038/gt.2008.78.
1.1.
2008
Kala, K; Jukkola, T; Pata, I; Partanen, J. (2008). Analysis of the midbrain-hindbrain boundary cell fate using a boundary cell-specific Cre-mouse strain. Genesis, 46 (1), 29−36.
1.1.
2006
Speek M, Njunkova O, Pata I, Valdre E, Kogerman P. (2006). A potential role of alternative splicing in the regulation of the transcriptional activity of human GLI2 in gonadal tissues. BMC Molecular Biology, 7 (13), 1−13.10.1186/1471-2199-7-13.
1.1.
2001
Meng, XJ.; Pata, I.; Pedrono, E.; Popsueva, A.; de Rooij, DG.; Janne, M.; Rauvala, H.; Sariola, H. (2001). Transient disruption of spermatogenesis by deregulated expression of neurturin in testis. Molecular and Cellular Endocrinology, 184, 33−39.
1.1.
2001
Krinka, D.; Raid, R.; Pata, I.; Karner, J.; Maimets, T. (2001). In situ hybridisation of chick embryos with p53-specific probe and their immunostaining with anti-p53 antibodies. Anatomy and Embryology, 204 (3), 207−215.
1.1.
2001
Karis, A.; Pata, I.; van Doorninck, JH.; Grosveld, F.; de Zeeuw, CI.; de Caprona, D.; Fritzsch, B. (2001). Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. Journal of Comparative Neurology, 429 (4), 615−630.

Industrial property

4.03.2020

Otsi projekti

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Asutus on projekti finantseerija   Asutus on projekti teostaja  
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Kõik   Tavaprojektid   Ülemprojektid   Alamprojektid  
Uus Frascati (2015)
Uus ja vana Frascati (otsing uue järgi väljastab ka seotud vanad)
Kõik
Käimasolevad
Lõppenud
Algus
Hajus
Täpne
Lihtotsing Tühjenda
  • Leitud 7 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
MUUV286'Repressorite teke ja funktsioon hedgehog signaali ülekandes01.06.200530.09.2007Priit KogermanTallinna Tehnikaülikool414 336,34 EUR
ETFETF6139Hedgehogi signaaliraja aktiivsuse moduleerimine in vivo: selle võimalused kasvajate ravis01.01.200531.12.2008Illar PataTallinna Tehnikaülikool, Matemaatika-loodusteaduskond26 270,25 EUR
MUUBF59In vivo bioluminestsents-kuvamise mudelite arendamine vähiteraapia mõju hindamiseks01.01.200731.12.2008Illar PataTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Geenitehnoloogia instituut15 977,91 EUR
ETFETF8116KASVAJA METASTASEERUMISE MOLEKULAARSED MEHHANISMID: OPTILISED KUVAMISMEETODID TEADAOLEVATE JA UUDSETE MOLEKULIDE ROLLIDE SELGITAMISEKS01.01.200931.12.2013Andres VeskeTallinna Tehnikaülikool; Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum; Tallinna Tehnikaülikool, TTÜ Tehnomeedikum70 093,28 EUR
SFSF0140145As08Tuumorprogressiooni molekulaarbioloogia: molekulaarsed mehhanismid ja biomeditsiinilised rakendused01.01.200831.12.2013Andres ValknaTallinna Tehnikaülikool, Matemaatika-loodusteaduskond616 089,84 EUR
SFSF_0222601As03Vähktõve molekulaarbioloogia: molekulaarsed mehhanismid ja biomeditsiinilised rakendused01.01.200331.12.2007Priit KogermanTallinna Tehnikaülikool, Matemaatika-loodusteaduskond0,00 EUR
SFSF0222601As03Vähktõve molekulaarbioloogia: molekulaarsed mehhanismid ja biomeditsiinilised rakendused01.01.200331.12.2007Priit KogermanTallinna Tehnikaülikool, Matemaatika-loodusteaduskond518 195,64 EUR