See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus
"Muu" projekt MARLA11135
MARLA11135 "Krambisündroomi mõju väikelastele ja lastele isheemilisele insuldi korral (1.07.2011−31.07.2014)", Anneli Kolk, Tartu Ülikool, Tartu Ülikool, Arstiteaduskond, Lastekliinik.
MARLA11135
Krambisündroomi mõju väikelastele ja lastele isheemilisele insuldi korral
SIPS - Impact of Seizures in Infants and Children with Ischemic Stroke
SIPS - Impact of Seizures in Infants and Children with Ischemic Stroke
1.07.2011
31.07.2014
Teadus- ja arendusprojekt
Muu
ETIS klassifikaatorAlamvaldkondCERCS klassifikaatorFrascati Manual’i klassifikaatorProtsent
3. Terviseuuringud3.7. Kliiniline meditsiinB640 Neuroloogia, neuropsühholoogia, neurofüsioloogia 3.2. Kliiniline meditsiin (anestesioloogia, pediaatria, sünnitusabi ja günekoloogia, sisehaigused, kirurgia, stomatoloogia, neuroloogia, psühhiaatria, radioloogia, terapeutika, otorinolarüngoloogia, oftalmoloogia)100,0
AsutusRollPeriood
Tartu Ülikoolpartner01.07.2011−31.07.2014
Tartu Ülikool, Arstiteaduskond, Lastekliinikpartner01.07.2011−31.07.2014
AsutusRiikTüüp
Pediatric Epilepsy Research Foundation
PerioodSumma
01.07.2011−31.07.20141 202,00 EUR
1 202,00 EUR

Despite a growing understanding of the significance of pediatric stroke, we have limited data on acute management, and on factors influencing long-term outcomes after stroke, including epilepsy. Information about how early seizures modify outcomes after childhood stroke is limited. Besides, occurrence and severity of post stroke epilepsy is poorly examined. Studies have found that cortical lesions and persistence of seizures beyond two weeks of the acute insult have previously been identified as risk factors for epilepsy, which appears to be an important determinant of cognitive outcome and treatment itself may adversely affect behavior and recovery. How epilepsy might modify long-term outcome after stroke is a critically important question. In this study, we propose to determine the importance of seizures in children with ischemic stroke in a multi-center, muiti-national study utilizing the existing International Pediatric Stroke Study (IPSS) infrastructure. The aims of study is to measure in neonates and children with arterial ischemic stroke (AIS) the frequency, characteristics and predictors of early (< 14 days) seizures and chronic seizures (occurring 14 days or longer after stroke) on the outcomes, including death and neurological disability at 3 months and 1 year. The study population will consist of a prospective cohort of neonatal and childhood AIS and cerebral sinovenous thrombosis (CSVT) patients enrolled at a subset of 15 IPSS sites over a one year period (anticipated start date July 2011, with follow-up continuing untii July 2013). Investigators collect additional seizure-related information acutely, at 3 months and 12 months post stroke. Follow-up data will be collection after 3 months bytelephone interview, after 12 m. during clinical visit. The initial datafrom this study will form the basis for future studies in this area and submission of a multicenter grant to the National Institute of Neurological Disorders and Stroke and to the American Heart Association. Projekti eelarve on tehtud ühe patsiendi kohta ja see pole ette teada, mitu sobivat patsienti uuringusse leida õnnestub. Kompensatsioon 1 patsiendi kohta kokku on arvestatud $850 USD. Omafinantseering projektis puudub. Üldkulu on 12% laekumiselt.
Despite a growing understanding of the significance of pediatric stroke, we have limited data on acute management, and on factors influencing long-term outcomes after stroke, including epilepsy. Information about how early seizures modify outcomes after childhood stroke is limited. Besides, occurrence and severity of post stroke epilepsy is poorly examined. Studies have found that cortical lesions and persistence of seizures beyond two weeks of the acute insult have previously been identified as risk factors for epilepsy, which appears to be an important determinant of cognitive outcome and treatment itself may adversely affect behavior and recovery. How epilepsy might modify long-term outcome after stroke is a critically important question. In this study, we propose to determine the importance of seizures in children with ischemic stroke in a multi-center, muiti-national study utilizing the existing International Pediatric Stroke Study (IPSS) infrastructure. The aims of study is to measure in neonates and children with arterial ischemic stroke (AIS) the frequency, characteristics and predictors of early (< 14 days) seizures and chronic seizures (occurring 14 days or longer after stroke) on the outcomes, including death and neurological disability at 3 months and 1 year. The study population will consist of a prospective cohort of neonatal and childhood AIS and cerebral sinovenous thrombosis (CSVT) patients enrolled at a subset of 15 IPSS sites over a one year period (anticipated start date July 2011, with follow-up continuing untii July 2013). Investigators collect additional seizure-related information acutely, at 3 months and 12 months post stroke. Follow-up data will be collection after 3 months bytelephone interview, after 12 m. during clinical visit. The initial datafrom this study will form the basis for future studies in this area and submission of a multicenter grant to the National Institute of Neurological Disorders and Stroke and to the American Heart Association.
KirjeldusProtsent
Alusuuring40,0
Rakendusuuring60,0