"Muu" projekt SARMP12203E
SARMP12203E "EGIDA - Autoimmunsuse epigeneetilised mehhanismid (1.09.2012−31.12.2013)", Pärt Peterson, Tartu Ülikool, Tartu Ülikool, Arstiteaduskond.
SARMP12203E
EGIDA - Autoimmunsuse epigeneetilised mehhanismid
EGIDA - Epigenetic mechanisms in immune deviation during autoimmunity
1.09.2012
31.12.2013
Teadus- ja arendusprojekt
Muu
ValdkondAlamvaldkondCERCS erialaFrascati Manual’i erialaProtsent
3. Terviseuuringud3.7. Kliiniline meditsiinB500 Immunoloogia, seroloogia, transplantoloogia3.2. Kliiniline meditsiin (anestesioloogia, pediaatria, sünnitusabi ja günekoloogia, sisehaigused, kirurgia, stomatoloogia, neuroloogia, psühhiaatria, radioloogia, terapeutika, otorinolarüngoloogia, oftalmoloogia)100,0
AsutusRollPeriood
Tartu Ülikoolpartner01.09.2012−31.12.2013
Tartu Ülikool, Arstiteaduskondpartner01.09.2012−31.12.2013
AsutusRiikTüüp
Eesti Teadusagentuur
PerioodSumma
01.09.2012−31.12.201351 360,00 EUR
51 360,00 EUR

The role of epigenetics in thymic selection of T-cells has been proposed, however, the epigenetic patterns in thymic cell populations are poorly known. We aim to establish the epigenetic patterns, including CpG methylation and microRNA expression in thymic epithelial cells that are crucial for negative selection of autoreactive T cells to avoid autoimmunity and to maintain self-tolerance. To identify the epigenetic patterns of tissue-specific gene expression, we plan to sort out human thymic epithelial cells and thymocytes and to study their genome-wide methylation. Secondly we will study transcriptome analysis including microRNAs. The data collected from these experiments will reveal a collection of epigenetic patterns including CpG methylation and microRNA in thymic cells subsets.
The role of epigenetics in thymic selection of T-cells has been proposed, however, the epigenetic patterns in thymic cell populations are poorly known. We aim to establish the epigenetic patterns, including CpG methylation and microRNA expression in thymic epithelial cells that are crucial for negative selection of autoreactive T cells to avoid autoimmunity and to maintain self-tolerance. To identify the epigenetic patterns of tissue-specific gene expression, we plan to sort out human thymic epithelial cells and thymocytes and to study their genome-wide methylation. Secondly we will study transcriptome analysis including microRNAs. The data collected from these experiments will reveal a collection of epigenetic patterns including CpG methylation and microRNA in thymic cells subsets.
TegevusProtsent
Alusuuring100,0