Antud projekti eesmärgiks on uurida tüseduse ja geneetiliste markerite vahelist seost. Selle raames keskendutakase kandidaatlookustele, mis on tuvastatud suurte ülegenoomsete analüüside raameis.
Aim of the project is to investigating the genetic basis of obesity by applying the data from genome wide association analyses in a canditate gene approach. Over the five years, the University of Tartu investigators will select, plate and transfer 1,000 samples to Boston, including 250 samples each from the top and bottom 1% of the BMI (which is the proxy to obesity), stratified by gender. University of Tartu investigators will assemble, curate and share phenotype data on these samples with the Boston group, receive sequencing and genotyping data, and participate in the analysis of the genotype and phenotype data. University of Tartu investigators will also provide expert input on the Estonia Biobank cohort phenotype data and epidemiologic considerations relevant to analysis of these data.