Knee Osteoarthritis (OA) is estimated as the fourth leading cause of disability. According to the World Health Organization, more than 150 million (± 2.5%) people suffer from OA worldwide (WHO 2004). This figure even rises to 10% for population above the age of 60 years (Symmons et al., 2003). In almost 30% of these cases, OA leads to moderate to severe disability. Diseases of muscle and bone tissues are the most common causes why patients seek for the medical aid and their impact for society is substantial. Thereby, it is the most common joint disease for the middle-aged and older population (Buckwalter and Martin 2006). Over the next 10-20 years the aging population will increase significantly, escalating the number of OA. Taken together, these factors are the main contributors to the progressive loss of quality of life in the most of the countries and musculoskeletal diseases are global health care problem. Overall Aim: To set up an international collaboration with the effort to perform mechanistic comprehensive analysis of knee OA for effective diagnosis and intervention.