"ERMOS järeldoktori uurimistoetus" projekt ERMOS139
ERMOS139 (ERMOS139) "The role of mTERF protein family members in the mitochondrial function of Drosophila melanogaster (1.01.2013−31.12.2014)", Priit Jõers, Eesti Biokeskus.
ERMOS139
The role of mTERF protein family members in the mitochondrial function of Drosophila melanogaster
1.01.2013
31.12.2014
Teadus- ja arendusprojekt
ERMOS järeldoktori uurimistoetus
ETIS klassifikaatorAlamvaldkondCERCS klassifikaatorFrascati Manual’i klassifikaatorProtsent
1. Bio- ja keskkonnateadused1.1. BiokeemiaP320 Nukleiinhappesüntees, proteiinisüntees 1.5. Bioteadused (bioloogia, botaanika, bakterioloogia, mikrobioloogia, zooloogia, entomoloogia, geneetika, biokeemia, biofüüsika jt34,0
1. Bio- ja keskkonnateadused1.3. GeneetikaB220 Geneetika, tsütogeneetika 1.5. Bioteadused (bioloogia, botaanika, bakterioloogia, mikrobioloogia, zooloogia, entomoloogia, geneetika, biokeemia, biofüüsika jt33,0
1. Bio- ja keskkonnateadused1.1. BiokeemiaP310 Proteiinid, ensümoloogia1.5. Bioteadused (bioloogia, botaanika, bakterioloogia, mikrobioloogia, zooloogia, entomoloogia, geneetika, biokeemia, biofüüsika jt33,0
AsutusRollPeriood
Eesti Biokeskuskoordinaator01.09.2012−31.08.2014
PerioodSumma
01.01.2014−31.12.201469 220,00 EUR
69 220,00 EUR

Mitochondria, eukaryotic organelles, perform a range of essential tasks in cells, perhaps the best known is ATP production through oxydative phosphorylation. Their dysfunction have been implicated in a number of fatal inherited disorders, in tumorigenesis (Warburg effect), in apoptosis and also as a theoretical cause for ageing. Since this organelle carries a certain number of essential genes in its genome, which is a heavily reduced remnant of its ancestor’s genome, proper synthesis, repair and expression of this mitochondrial DNA (mtDNA) is vital for proper mitochondrial function. A family of DNA-binding proteins, mTERF’s, is drawing increasingly more attention among factors of mitochondrial replication and transcription machineries. Originally named after it first discovered member, a mitochondrial transcription termination factor 1 (mTERF1), their function has been described to be much broader than just transcription termination, extending to mtDNA synthesis, mt gene expression regulation and even mitoribosomal RNA methylation. I have been studying the mTERF1 homologue in Drosophila melanogaster (DmTTF) and found this protein in addition to transcription termination to be essential for coordinating the passage of transcription and replication machineries, regulating the recombination levels of mtDNA and modulating the use of RNA as an intermediate in lagging strand synthesis. However, despite being implicated in a number of essential processes in mt genome maintenance, its precise function and possible association with other members of mtDNA maintenance complex remains elusive. By building on my previous work, I apply for ERMOS postdoctoral grant to study the role of DmTTF in mitochondrial (dys)function in D. melanogaster.