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"Muu" projekt MARTO13136R
MARTO13136R "HypOrth - Uus lähenemine hüpoallergilise implantaadi materjali arendamiseks ortopeedias. Sammud personaalse meditsiini suunas (1.08.2013−31.07.2018)", Aare Märtson, Sulev Kõks, Tartu Ülikool, Arstiteaduskond, Traumatoloogia ja ortopeedia kliinik, Tartu Ülikool, Meditsiiniteaduste valdkond, kliinilise meditsiini instituut.
MARTO13136R
HypOrth - Uus lähenemine hüpoallergilise implantaadi materjali arendamiseks ortopeedias. Sammud personaalse meditsiini suunas
HypOrth - New approaches in the development of Hypoallergenic implant material in Orthopedics: steps to personalised medicine
HypOrth - New approaches in the development of Hypoallergenic implant material in Orthopedics: steps to personalised medicine
1.08.2013
31.07.2018
Teadus- ja arendusprojekt
Muu
ETIS klassifikaatorAlamvaldkondCERCS klassifikaatorFrascati Manual’i klassifikaatorProtsent
3. Terviseuuringud3.7. Kliiniline meditsiinB600 Kirurgia, ortopeedia, traumatoloogia 3.2. Kliiniline meditsiin (anestesioloogia, pediaatria, sünnitusabi ja günekoloogia, sisehaigused, kirurgia, stomatoloogia, neuroloogia, psühhiaatria, radioloogia, terapeutika, otorinolarüngoloogia, oftalmoloogia)100,0
AsutusRiikTüüp
Euroopa Komisjon
PerioodSumma
01.08.2013−31.07.2018900 000,00 EUR
900 000,00 EUR
7.raamprogramm

Due to increasing life span of human beings in industrialized countries the diagnosis of osteoarthritis is the most common indication for implantation of artificial joints. The implantation of total hip (THA) and total knee arthroplasties (TKA) is based on 50 years of experience and is one of the most successful and most common treatments for osteoarthritis of the joint. Although the clinical results of total joint arthroplasty are usually excellent, some implants develop loosening and require revision. Revision surgery is more complex than primary joint replacement, takes longer to perform, implants are more expensive and the patient`s hospital stay is prolonged, incurring higher costs. Until now, no predictive measures or indicative markers are available to predict an adverse immune reaction (AIR) to implant material, since results of patch tests of skin for allergy do not correlate with potential of implant hypersensitivity. In addition, no clear strategic diagnostic methods have been found to differentiate prosthetic loosening caused by AIR from a low-grade infection. The materials used for artificial prosthesis by default are Titanium (TiAl6V4, TiAl6Nb7 – forged alloy), CoCrMo (forged alloy), ceramics and UHMWPE (Ultra High Molecular Weight PolyEthylene). Despite application of different biocompatible materials the ultimate material with properties of native joints has not been found to date. This project provides a comprehensive view on the problem of adverse immune reactions to implant material including immunological, genomic, reverse engineering, microbiological, epidemiological and clinical aspects. The ultimate goals of our project are the development of novel orthopaedic implant prototype based on hypoallergenic materials and to define individual predictive and general diagnostic biomarkers for AIR.
Due to increasing life span of human beings in industrialized countries the diagnosis of osteoarthritis is the most common indication for implantation of artificial joints. The implantation of total hip (THA) and total knee arthroplasties (TKA) is based on 50 years of experience and is one of the most successful and most common treatments for osteoarthritis of the joint. Although the clinical results of total joint arthroplasty are usually excellent, some implants develop loosening and require revision. Revision surgery is more complex than primary joint replacement, takes longer to perform, implants are more expensive and the patient`s hospital stay is prolonged, incurring higher costs. Until now, no predictive measures or indicative markers are available to predict an adverse immune reaction (AIR) to implant material, since results of patch tests of skin for allergy do not correlate with potential of implant hypersensitivity. In addition, no clear strategic diagnostic methods have been found to differentiate prosthetic loosening caused by AIR from a low-grade infection. The materials used for artificial prosthesis by default are Titanium (TiAl6V4, TiAl6Nb7 – forged alloy), CoCrMo (forged alloy), ceramics and UHMWPE (Ultra High Molecular Weight PolyEthylene). Despite application of different biocompatible materials the ultimate material with properties of native joints has not been found to date. This project provides a comprehensive view on the problem of adverse immune reactions to implant material including immunological, genomic, reverse engineering, microbiological, epidemiological and clinical aspects. The ultimate goals of our project are the development of novel orthopaedic implant prototype based on hypoallergenic materials and to define individual predictive and general diagnostic biomarkers for AIR.
KirjeldusProtsent
Alusuuring100,0