See veebileht kasutab küpsiseid kasutaja sessiooni andmete hoidmiseks. Veebilehe kasutamisega nõustute ETISe kasutustingimustega. Loe rohkem
Olen nõus

Kersti Tepp

https://www.etis.ee/CV/Kersti_Tepp/est
kersti.tepp@kbfi.ee
A-4829-2012

Teenistuskäik

Töökohad ja ametid
10.10.2011–...   
Keemilise ja Bioloogilise Füüsika Instituut, Teadur (1,00)
01.09.2007–09.10.2011   
Keemilise ja Bioloogilise Füüsika Instituut, vaneminsener (1,00)
 
 
Haridustee
2007–2011   
TTÜ doktorant
1985–1990   
Tartu Ülikool keemia
 
 
Teadusorganisatsiooniline ja -administratiivne tegevus
2011−...   
Eesti Biokeemia Seltsi liige
2008−...   
Mitochondrial Physiology Society liige
2016−2020   
COST Action CA152 Mitochondrial fitness mapping MITOEAGLE projekti juhtivkomitee asendusliige

Kvalifikatsioon

Teaduskraadid
Kersti Tepp, doktorikraad, 2011, (juh) Raivo Vilu; Valdur Saks, Molecular System Bioenergetics of Cardiac Cells: Quantitative Analysis of Structure-Function Relationship (Molekulaarne süsteemibioenergeetika: südamerakkude struktuuri ja funktsiooni vaheliste suhete kvantitatiivne analüüs), Tallinna Tehnikaülikool, Matemaatika-loodusteaduskond, Keemiainstituut, Biotehnoloogia õppetool
Kersti Tepp, magistrikraad, 1990, (juh) Õunapuu, Lapse minateadvuse kujunemise ja IQ vahelised seosed, Tartu Ülikool.
 
 
Teaduspreemiad ja tunnustused
2012, Kersti Tepp, Konverentsi korraldajate nõukogu toetus osalemaks ettekandega konverentsil 10th New Frontiers in Basic Cardiovascular Research: France - New EU Members Meeting Hradec Kralove
2011, Kersti Tepp, FEBS stipendium osalemaks ettekandega FEBS aastakonverentsil Torinos
2010, Kersti Tepp, Biokeemia ja Biotehnoloogia Doktorikooli stipendium
2010, Kersti Tepp, ESF DoRa programmi stipendium Tegevus 8 Noorteadlaste osalemine rahvusvahelises teadmisteringluses, osalemine EBEC konverentsil Varssavis.
2009, Kersti Tepp, ESF DoRa programmi stipendium Tegevus 6 Doktorantide õpiränne
2008, Kersti Tepp, ESF DoRa programmi stipendium Tegevus 8 Noorteadlaste osalemine rahvusvahelises teadmisteringluses
2007, Kersti Tepp, Kristjan Jaagu stipendium
 
 
Teadustöö põhisuunad
ETIS VALDKOND: 1. Bio- ja keskkonnateadused; 1.12. Bio- ja keskkonnateadustega seotud uuringud, näiteks biotehnoloogia, molekulaarbioloogia, rakubioloogia, biofüüsika, majandus- ja tehnoloogiauuringud; CERCS VALDKOND: P330 Bioenergeetika

Lõppenud projektid

Juhendamisel väitekirjad

Juhendatud väitekirjad

Publikatsioonid

Klass
Aasta
Publikatsioon
 
1.1.
2022
Tepp, Kersti; Aid-Vanakova, Jekaterina; Puurand, Marju; Timohhina, Natalja; Reinsalu, Leenu; Tein, Karin; Plaas, Mario; Shevchuk, Igor; Terasmaa, Anton; Kaambre, Tuuli; (2022). Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochemistry and Biophysics Reports (101250). DOI: 10.1016/j.bbrep.2022.101250.
1.1.
2021
Kaup, Karl Kristjan; Toom, Lauri; Truu, Laura; Miller,Sten; Puurand, Marju; Tepp, Kersti; Käämbre Tuuli; Reile, Indrek (2021). A line-broadening free real-time 31P Pure Shift NMR method for phosphometabolomic analysis. The Analyst, 1−5. DOI: 10.1039/D1AN01198G.
1.1.
2020
Tepp, Kersti; Puurand, Marju; Timohhina, Natalja; Aid-Vanakova, Jekaterina; Reile, Indrek; Shevchuk, Igor; Chekulayev, Vladimir; Eimre, Margus; Peet, Nadežda; Kadaja, Lumme; Paju, Kalju; Kaambre, Tuuli (2020). Adaptation of mice striated muscles to wolframin deficiency: alterations in cellular bioenergetics. Biochemica et Biophysica Acta. DOI: 10.1016/j.bbagen.2020.129523.
1.1.
2020
Rebane-Klemm, Egle; Truu, Laura; Reinsalu, Leenu; Puurand, Marju; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Tepp, Kersti; Bogovskaja, Jelena; Afanasjev, Vladimir; Suurmaa, Külliki; Valvere, Vahur; Käämbre, Tuuli (2020). Mitochondrial Respiration in KRAS and BRAF Mutated Colorectal Tumors and Polyps. Cancers, 12 (4), ARTN 815. DOI: 10.3390/cancers12040815.
1.1.
2020
Timohhina, Natalja; Cerrato, Carmine Pasquale; Kurrikoff, Kaido; Chekulayev, Vladimir; Aid-Vanakova, Jekaterina; Puurand, Marju; Tepp, Kersti; Shevchuk, Igor; Langel, Ulo; Kaambre, Tuuli (2020). Viability and mitochondrial bioenergetic functions in human colon cancer cells are not affected by treatment with peptides mtCPP1, UPF25, mtgCPP, and mtCPP1gHO. bioRxiv, 1−20. DOI: 10.1101/2020.07.03.185967.
1.1.
2019
Mado, Kati; Chekulayev, Vladimir; Shevchuk, Igor; Puurand, Marju; Tepp, Kersti; Kaambre, Tuuli (2019). On the role of tubulin, plectin, desmin and vimentin in the regulation of mitochondrial energy fluxes in muscle cells. American Journal of Physiology - Cell Physiology, 316 (5), C657−C667. DOI: 10.1152/ajpcell.00303.2018.
1.1.
2019
Puurand, Marju; Tepp, Kersti; Timohhina, Natalja; Aid, Jekaterina; Shevchuk, Igor; Chekulayev, Vladimir; Kaambre, Tuuli. (2019). Tubulin βII and βIII Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease. Cells. DOI: 10.3390/cells8030239.
1.1.
2019
Makrecka‐Kuka, Marina; Liepinsh, Edgars; Murray, Andrew J.; Lemieux, Hélène; Dambrova, Maija; Tepp, Kersti; Puurand, Marju; Käämbre, Tuuli; Han, Woo Hyun; de Goede, Paul; O’Brien, Katie A.; Turan, Belma; Tuncay, Erkan; Olgar, Yusuf; Rolo, Anabela P.; Palmeira, Carlos M.; Boardman, Neoma T; Wüst, Rob CI; Larsen, Terje S (2019). Altered mitochondrial metabolism in the insulin resistant heart. Acta Physiologica. DOI: 10.1111/apha.13430.
1.1.
2019
Gnaiger, E; Aasander, Frostner, E; Abumrad, NA; Acuna-Castroviejo, D; Adams, SH; Ahn, B; Ali, SS; Alves, MG; Amati, F; Amoedo, ND; Andreadou, I; Arago, Belenguer, M; Aral, C; Arandarcikaite, O; Armand, AS; Arnould, T; Avram, VF; Bailey, DM; Bajpeyi, S; Bajzikova, M ... Zvejniece, L (2019). Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology. 1−40. DOI: 10.26124/mitofit:190001.v6.
1.1.
2018
Puurand, Marju; Tepp, Kersti; Klepinin, Aleksandr; Klepinina, Lyudmila; Shevchuk, Igor; Kaambre, Tuuli (2018). Intracellular Energy-Transfer Networks and High-Resolution Respirometry: A Convenient Approach for Studying Their Function. International Journal of Molecular Sciences, 19 (10). DOI: 10.3390/ijms19102933.
1.1.
2018
Ounpuu, Lyudmila; Truu, Laura; Shevchuk, Igor; Chekulayev, Vladimir; Klepinin, Aleksandr; Koit, Andre; Tepp, Kersti; Puurand, Marju; Rebane-Klemm, Egle; Käämbre, Tuuli (2018). Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochemistry and Cell Biology. DOI: 10.1139/bcb-2018-0076.
1.1.
2018
Klepinin, Aleksandr; Ounpuu, Lyudmila; Mado, Kati; Truu, Laura; Chekulayev, Vladimir; Puurand, Marju; Shevchuk, Igor; Tepp, Kersti; Planken, Anu; Kaambre, Tuuli (2018). The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. Journal of Bioenergetics and Biomembranes. DOI: 10.1007/s10863-018-9765-9.
5.1.
2018
Tepp, Kersti; Puurand, Marju; Klepinin, Aleksandr; Reile, Indrek; Kaambre, Tuuli; (2018). Alterations in energy transfer pathways in Wfs1 deficient mice. Biochimica et Biophysica Acta (BBA) - Bioenergetics, Volume 1859, Supplement, September 2018,, 1859: 20th European Bioenergetics Conference, August 25-30, 2018. Budapest, Hungary: European Bioenergetics Conference, e92.
5.2.
2018
Tepp, Kersti; Puurand, Marju; Klepinin, Aleksandr; Kaambre, Tuuli; (2018). Energy transfer in development and pathology – valuable information from oxygraphic measurements. Emerging Concepts in Mitochondrial Biology. Rehovot, Israel: Weizmann Institute of Science, 136.
1.1.
2017
Ounpuu, Lyudmila; Klepinin, Aleksandr; Pook, Martin; Teino, Indrek; Peet, Nadezda; Paju, Kalju; Tepp, Kersti; Chekulayev, Vladimir; Shevchuk, Igor; Koks, Sulev; Maimets, Toivo; Kaambre, Tuuli (2017). 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochimica et Biophysica Acta (BBA) - General Subjects, 1861, 2146−2154. DOI: 10.1016/j.bbagen.2017.05.020.
1.1.
2017
Koit, Andre; Shevchuk, Igor; Ounpuu, Lyudmila; Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Tepp, Kersti; Puurand, Marju; Truu, Laura; Heck, Karoliina; Valvere, Vahur; Guzun, Rita; Kaambre, Tuuli (2017). Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently. Oxidative Medicine and Cellular Longevity, 2017 (1372640), 1−16. DOI: 10.1155/2017/1372640.
1.1.
2017
Tepp, K.; Puurand, M.; Timohhina, N.; Adamson, J.; Klepinin, A.; Truu, L.; Shevchuk, I.; Chekulayev, V.; Kaambre, T. (2017). Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Molecular and Cellular Biochemistry, 432 (1-2), 141−158. DOI: 10.1007/s11010-017-3005-1.
5.2.
2017
Puurand, Marju; Tepp, K.; Klepinin, A.; Kaambre, T. (2017). Cellular phosphotransfer networks as a target of bioenergetic research – methods of oxygraphic study. 12th Conference on Mitochondrial Physiology. The role of mitochondria in lifestyle and metabolic syndrome - COST MitoEAGLE perspectives: Hradec Králové, Czech Republic;15-18 November 2017. Hradec Králové, Czech Republic: 12th Conference on Mitochondrial Physiology, 64−65.
1.1.
2016
Tepp, K.; Timohhina, N.; Puurand, M.; Klepinin,A.; Chekulayev, V.; Shevchuk,I.; Kaambre, T. (2016). Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies. Ageing Research Reviews, 28, 1−14. DOI: 10.1016/j.arr.2016.04.001.
5.1.
2016
Kersti Tepp; Marju Puurand; Natalja Timohhina; Jasper Adamson; Aleksandr Klepinin; Igor Shevchuk; Vladimir Chekulayev; Tuuli Käämbre (2016). New aspects of the bioenergetics of the aging heart — Changes in Intracellular Energetic Unit. In: Paolo Bernardi (Ed.). Biochimica et Biophysica Acta (BBA) - Bioenergetics (e100). EBEC 2016: 19th European Bioenergetics Conference, 02-07 July 2016 Riva del Garda, Italy. Elsevier. (Supplement). DOI: 10.1016/j.bbabio.2016.04.338.
1.1.
2015
Guzun, Rita; Kaambre, Tuuli; Bagur, Rafaela; Grichine, Alexei; Usson, Yves; Varikmaa, Minna; Anmann, Tiia; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Boucher, Francois; Dos Santos, Pierre; Schlattner, Uwe; Wallimann, Theo; Kuznetsov, Andrey; Dzeja, Petras; Aliev, Mayis; Saks, Valdur (2015). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica, 213 (1), 84−106. DOI: 10.1111/apha.12287.
1.1.
2015
Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Koit, Andre; Kaldma, Andrus; Klepinin, Aleksandr; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Ounpuu, Lyudmila; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Kaambre, Tuuli (2015). Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochemistry and Biophysics Reports, 4, 111−125.
5.2.
2015
Tepp, K.; Klepinin, A.; Timohhina, N.; Chekulayev, V.; Shevchuk, I.; Kaambre, T. (2015). Changes in energy transfer regulation during development and aging. 11th MiPconference on Mitochondrial Physiology. Lucni­ Bouda, Pec pod Snezkou, Czech Republic: MiPsociety, 76−77.
1.1.
2014
Kaldma, Andrus; Klepinin, Aleksandr; Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Varikmaa, Minna; Koit, Andre; Planken, Margus; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Rebane, Egle; Kaambre, Tuuli. (2014). An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. The International Journal of Biochemistry & Cell Biology, 55, 171−186. DOI: 10.1016/j.biocel.2014.09.004.
1.1.
2014
Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Shevchuk, Igor; Tepp, Kersti; Kaldma, Andrus; Koit, Andre; Saks, Valdur; Kaambre, Tuuli (2014). Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. Journal of Bioenergetics and Biomembranes, 46 (1), 17−31. DOI: 10.1007/s10863-013-9529-5.
1.1.
2014
Anmann, Tiia; Varikmaa, Minna; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor, Chekulayev, Vladimir'; Saks, Valdur; Kaambre, Tuuli. (2014). Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1837 (8), 1350−1361. DOI: 10.1016/j.bbabio.2014.03.015.
1.1.
2014
Varikmaa, Minna; Bagur, Rafaela; Käämbre, Tuuli; Grichine, Alexei; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Metsis, Madis; Boucher, Francois; Saks, Valdur; Kuznetsov, Andrey V.; Guzun, Rita (2014). Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1837 (2), 232−245. DOI: 10.1016/j.bbabio.2013.10.011.
1.1.
2014
Tepp, K.; Mado, K.; Varikmaa, M.; Klepinin, A.; Timohhina, N.; Shevchuk, I.; Chekulayev, V.; Kuznetsov, A. V.; Guzun, R.; Kaambre, T. (2014). The role of tubulin in the mitochondrial metabolism and arrangement in muscle cells. Journal of Bioenergetics and Biomembranes, 46, 421−434.
5.1.
2014
Timohhina, N; Tepp, K; Klepinin, A; Mado, K; Chekulayev, V; Shevchuk, I; Kaambre, T. (2014). Age-related changes in the cardiac cell functioning. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1837: 18th European Bioenergetics Conference, Lisbon, Portugal, 12-17 July 2014. Elsevier, e65.
1.1.
2013
Kaambre, Tuuli; Chekulayev, Vladimir; Shevchuk, Igor; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Bagur, Rafaela; Klepinin, Aleksandr; Anmann, Tiia; Koit, Andre; Kaldma, Andrus; Guzun, Rita; Valvere, Vahur; Saks, Valdur (2013). Metabolic Control Analysis of Respiration in Human Cancer Tissue. Frontiers in Physiology, 4, 1−6. DOI: 10.3389/fphys.2013.00151.
1.3.
2013
Käämbre, Tuuli; Koit, Andre; Ševtšuk, Igor; Tšekulajev, Vladimir; Tepp, Kersti; Timohhina, Natalja; Bogovskaja, Jelena; Valvere, Vahur; Saks, Valdur (2013). Uusi suundi kasvajate energiametabolismi uuringutes. Eesti Arst, 92 (5), 261−267.
1.3.
2013
Anmann, Tiia; Varikmaa, Minna; Tepp, Kersti; Timohhina, Natalja; Ševtšuk, Igor; Tšekulajev, Vladimir; Saks, Valdur; Käämbre, Tuuli (2013). Südamerakkude sünnijärgse arengu bioenergeetilised aspektid: struktuuri ja funktsiooni vaheliste seoste väljakujunemine. Eesti Arst, 92 (7), 372−381.
3.5.
2013
Varikmaa, M; Bagur, R; Metsis, M; Grichine, A; Tepp, K; Käämbre, T; Saks, V and Guzun, R. (2013). Fine-tuning mitochondria function by betaII tubulin in striated muscles. Barcelona BioMed Conference "The microtubule cytoskeleton in development and disease"..
5.1.
2013
Karu, M ; Bagun, R ; Metsis, M ; Grichine, A; Tepp, K ; Kaambre, T; Saks, V; Guzun, R (2013). Unpolymerized beta II Tubulin in Regulation of Mitocondrial Function in Muscle Cells. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. , 302A−302A. (2; 1).
5.1.
2013
Koit, Andre; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Bogovskaja, Jelena; Valvere, Vahur Saks, Valdur; Kaambre, Tuuli (2013). Bioenergetic profiling of human breast cancer: unusual organisation of the respiratory chain. Mitochondrion, 13(6): Mitochondrial Medicine 2013, Newport Beach, CA, USA. Newport Beach, CA, USA, 922. DOI: 10.1016/j.mito.2013.07.064.
5.1.
2013
Quetglas, RB; Karu-Varikmaa, M; Tepp, K; Metsis, M; Kaambre, T; Grichine, A; Boucher, F; Saks, V; Guzun, R (2013). Regulation of Respiration in Permeabilized Muscle Cells: Apparent KM for ADP Shows the Mitochondrial Outer Membrane Permeability. BIOPHYSICAL JOURNAL, 104: 57th Annual Meeting of the Biophysical-Society, Philadelphia, PA. , 447A−448A. (2; 1).
1.1.
2012
Käämbre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Tepp, K.; Bogovskaja, J.; Kütner, R.; Valvere, V.; Saks, V. (2012). Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. Journal of Bioenergetics and Biomembranes, 44 (5), 539−558. DOI: 10.1007/s10863-012-9457-9.
1.1.
2012
Gonzalez-Granillo, M.; Grichine, A.; Guzun, R.; Ussov, Y.; Tepp, K.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Kuznetsov, A.V.; Grimm, M.; Saks, V.; Käämbre, T. (2012). Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. Journal of Molecular and Cellular Cardiology, 52, 437−447. DOI: 10.1016/j.yjmcc.2011.07.027.
1.1.
2012
Saks, V.; Kuznetsov, A.V.; Gonzalez-Granillo, M.; Tepp, K.; Timohhina, N.; Karu-Varikmaa, M.; Käämbre, T.; Santos, P.D.; Boucher, F.; Guzun, R. (2012). Intracellular energetic Units regulate metabolism in cardiac cells. Journal of Molecular and Cellular Cardiology, 419−436. DOI: 10.1016/j.yjmcc.2011.07.015.
5.1.
2012
Tepp, K.; Kaambre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Valvere, V.; Saks, V. (2012). Comparative investigation of bioenergetic properties of human colorectal and breast cancer. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S136. (supplement to volume 1817).
5.2.
2012
Tepp, K.; Timohhina, N.; Chekulayev, V.; Saks, V.; Kaambre, T.; Shevchuk, I. (2012). Control Analysis of Intracellular Energetic Unit in cardiac cell. In New Frontiers in Basic Cardiovascular Research 2012 : 10th Meeting of France - New EU Countries. From Basic Cardiovascular Research Towards Effective Therapeutics. June 12-15, 2012; Hradec Kralove, Czech Republic, Hradec Kralove. , 39−39.
1.1.
2011
Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Kuznetsov, Andrey V.; Guzun, Rita; Saks, Valdur; Käämbre, Tuuli (2011). High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1807 (12), 1549−1561. DOI: 10.1016/j.bbabio.2011.08.005.
1.1.
2011
Guzun, R.; Timohhina, N.; Tepp, K.; Gonzalez-Granillo, M.; Shevchuk, I.; Chekulayev, V.; Kuznetsov, A.V.; Käämbre, T.; Saks, V.A. (2011). Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function. Amino Acids, 40, 1333−1348.
1.1.
2011
Martma, K.; Habicht, K.-L.; Martinez Ramirez, X.; Tepp, K.; Käämbre, T.; Volobujeva, O.; Shimmo, R. (2011). Polydopamine as an adhesive coating for open tubular capillary electrochromatography. Electrophoresis, 32 (9), 1054−1060. DOI: 10.1002/elps.201000569.
5.1.
2011
Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux control with mitochondrial interactosome in cardiac cell. FEBS Journal, 278, 377−377.
1.1.
2010
Tepp, Kersti; Timohhina, Natalya; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes - experimental study. Acta Biochimica Polonica, 57 (4), 421−430.
1.1.
2010
Saks, Valdur; Guzun, Rita; Timohhina, Natalja; Tepp, Kersti; Varikmaa, Minna; Monge, Claire; Beraud, Nathalie; Käämbre, Tuuli; Kuznetsov, Andrey; Kadaja, Lumme; Eimre, Margus; Seppet, Enn (2010). Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1797 (6-7), 678−697. DOI: 10.1016/j.bbabio.2010.01.011.
3.1.
2010
Monge, Claire; Guzun, Rita; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Sikk, Peeter; Käämbre, Tuuli; Saks, Valdur (2010). Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells. In: Oliver L. Svensson (Ed.). Mitochondria: Structure, Functions and Dysfunctions (441−470). . Nova Science Publisher Inc..
5.1.
2010
Tepp, Kersti; Timohhina, Natalja; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−139. (Supplement 1). DOI: 10.1016/j.bbabio.2010.04.413.
1.1.
2009
Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.
1.1.
2009
Guzun, R.; Timohhina, N.; Tepp, K.; Monge, C.; Käämbre, T.; Sikk, P.; Kuznetsov, AV.; Pison, C.; Saks, V. (2009). Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ importance of system level properties. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1787 (9), 1089−1105. DOI: 10.1016/j.bbabio.2009.03.024.
1.1.
2009
Monge, Claire; Beraud, Nathalie; Tepp, Kersti; Pelloux, Sophie; Chahboun, Siham; Käämbre, Tuuli; Kadaja, Lumme; Roosimaa, Mart; Piirsoo, Andres; Tourneur, Yves; Kuznetsov, Andrey V; Saks, Valdur; Seppet, Enn (2009). Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Canadian Journal of Physiology and Pharmacology, 87 (4), 318−326.
1.1.
2009
Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu; Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.
1.3.
2008
Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Tiivel, Toomas; Timohhina, Natalja; Nutt, Anu; Tepp, Kersti; Saks, Valdur (2008). Südamelihase rakkude struktuuri olulisusest rakuhingamise regulatsioonis. Eesti Arst, 1, 19−22.
21.03.2022

Kersti Tepp

https://www.etis.ee/CV/Kersti_Tepp/eng
kersti.tepp@kbfi.ee
A-4829-2012

Career

Institutions and positions
10.10.2011–...   
National Institute of Chemical Physics and Biophysics, Researcher (1,00)
01.09.2007–09.10.2011   
National Institute of Chemical Physics and Biophysics, senior engineer (1,00)
 
 
Education
2007–2011   
TTU PhD student
1985–1990   
The Universty of Tartu chemistry
 
 
R&D related managerial and administrative work
2011−...   
Member of Estonian Biochemical Society
2008−...   
Member of Mitochondrial Physiology Society
2016−2020   
Substitute member of the Management Committee of COST Action CA15203 Mitochondrial fitness mapping MITOEAGLE project

Qualifications

Academic degrees
Kersti Tepp, Doctor's Degree, 2011, (sup) Raivo Vilu; Valdur Saks, Molecular System Bioenergetics of Cardiac Cells: Quantitative Analysis of Structure-Function Relationship, Tallinn University of Technology Faculty of Science, Department of Chemistry, Chair of Biotechnology
Kersti Tepp, Master's Degree, 1990, (sup) Õunapuu, Lapse minateadvuse kujunemise ja IQ vahelised seosed, University of Tartu.
 
 
Honours & awards
2012, Kersti Tepp, Scholarship of Conference for participation in 10th New Frontiers in Basic Cardiovascular Research: France - New EU Members Meeting Hradec Kralove
2011, Kersti Tepp, Scholarship of FEBS for participation in 30th FEBS conference in Torino
2010, Kersti Tepp, Scholarship of Doctoral School in Biomedicine and Biotechnology
2010, Kersti Tepp, Scholarship of Doctoral Studies and Internationalisation Programme DoRa Activity 8 Participation on International research conferences. Participation in EBEC conference in Warsaw.
2009, Kersti Tepp, Scholarship of Doctoral Studies and Internationalisation Programme DoRa Activity 6 Mobility of Estonian doctoral students
2008, Kersti Tepp, Scholarship of Doctoral Studies and Internationalisation Programme DoRa Activity 8 Participation on International research conferences
2007, Kersti Tepp, Archimedes Foundation Scholarship of Kristjan Jaak
 
 
Fields of research
ETIS RESEARCH FIELD: 1. Biosciences and Environment; 1.12. Biotechnology, Molecular Biology, Cell Biology, Biophysics and Economic and Technological Research relating to Bio- and Environmental Sciences; CERCS RESEARCH FIELD: P330 Bioenergetics
 
 

Completed projects

Dissertations under supervision

Supervised dissertations

Publications

Category
Year
Publication
 
1.1.
2022
Tepp, Kersti; Aid-Vanakova, Jekaterina; Puurand, Marju; Timohhina, Natalja; Reinsalu, Leenu; Tein, Karin; Plaas, Mario; Shevchuk, Igor; Terasmaa, Anton; Kaambre, Tuuli; (2022). Wolframin deficiency is accompanied with metabolic inflexibility in rat striated muscles. Biochemistry and Biophysics Reports (101250). DOI: 10.1016/j.bbrep.2022.101250.
1.1.
2021
Kaup, Karl Kristjan; Toom, Lauri; Truu, Laura; Miller,Sten; Puurand, Marju; Tepp, Kersti; Käämbre Tuuli; Reile, Indrek (2021). A line-broadening free real-time 31P Pure Shift NMR method for phosphometabolomic analysis. The Analyst, 1−5. DOI: 10.1039/D1AN01198G.
1.1.
2020
Tepp, Kersti; Puurand, Marju; Timohhina, Natalja; Aid-Vanakova, Jekaterina; Reile, Indrek; Shevchuk, Igor; Chekulayev, Vladimir; Eimre, Margus; Peet, Nadežda; Kadaja, Lumme; Paju, Kalju; Kaambre, Tuuli (2020). Adaptation of mice striated muscles to wolframin deficiency: alterations in cellular bioenergetics. Biochemica et Biophysica Acta. DOI: 10.1016/j.bbagen.2020.129523.
1.1.
2020
Rebane-Klemm, Egle; Truu, Laura; Reinsalu, Leenu; Puurand, Marju; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Tepp, Kersti; Bogovskaja, Jelena; Afanasjev, Vladimir; Suurmaa, Külliki; Valvere, Vahur; Käämbre, Tuuli (2020). Mitochondrial Respiration in KRAS and BRAF Mutated Colorectal Tumors and Polyps. Cancers, 12 (4), ARTN 815. DOI: 10.3390/cancers12040815.
1.1.
2020
Timohhina, Natalja; Cerrato, Carmine Pasquale; Kurrikoff, Kaido; Chekulayev, Vladimir; Aid-Vanakova, Jekaterina; Puurand, Marju; Tepp, Kersti; Shevchuk, Igor; Langel, Ulo; Kaambre, Tuuli (2020). Viability and mitochondrial bioenergetic functions in human colon cancer cells are not affected by treatment with peptides mtCPP1, UPF25, mtgCPP, and mtCPP1gHO. bioRxiv, 1−20. DOI: 10.1101/2020.07.03.185967.
1.1.
2019
Mado, Kati; Chekulayev, Vladimir; Shevchuk, Igor; Puurand, Marju; Tepp, Kersti; Kaambre, Tuuli (2019). On the role of tubulin, plectin, desmin and vimentin in the regulation of mitochondrial energy fluxes in muscle cells. American Journal of Physiology - Cell Physiology, 316 (5), C657−C667. DOI: 10.1152/ajpcell.00303.2018.
1.1.
2019
Puurand, Marju; Tepp, Kersti; Timohhina, Natalja; Aid, Jekaterina; Shevchuk, Igor; Chekulayev, Vladimir; Kaambre, Tuuli. (2019). Tubulin βII and βIII Isoforms as the Regulators of VDAC Channel Permeability in Health and Disease. Cells. DOI: 10.3390/cells8030239.
1.1.
2019
Makrecka‐Kuka, Marina; Liepinsh, Edgars; Murray, Andrew J.; Lemieux, Hélène; Dambrova, Maija; Tepp, Kersti; Puurand, Marju; Käämbre, Tuuli; Han, Woo Hyun; de Goede, Paul; O’Brien, Katie A.; Turan, Belma; Tuncay, Erkan; Olgar, Yusuf; Rolo, Anabela P.; Palmeira, Carlos M.; Boardman, Neoma T; Wüst, Rob CI; Larsen, Terje S (2019). Altered mitochondrial metabolism in the insulin resistant heart. Acta Physiologica. DOI: 10.1111/apha.13430.
1.1.
2019
Gnaiger, E; Aasander, Frostner, E; Abumrad, NA; Acuna-Castroviejo, D; Adams, SH; Ahn, B; Ali, SS; Alves, MG; Amati, F; Amoedo, ND; Andreadou, I; Arago, Belenguer, M; Aral, C; Arandarcikaite, O; Armand, AS; Arnould, T; Avram, VF; Bailey, DM; Bajpeyi, S; Bajzikova, M ... Zvejniece, L (2019). Mitochondrial respiratory states and rates: Building blocks of mitochondrial physiology. 1−40. DOI: 10.26124/mitofit:190001.v6.
1.1.
2018
Puurand, Marju; Tepp, Kersti; Klepinin, Aleksandr; Klepinina, Lyudmila; Shevchuk, Igor; Kaambre, Tuuli (2018). Intracellular Energy-Transfer Networks and High-Resolution Respirometry: A Convenient Approach for Studying Their Function. International Journal of Molecular Sciences, 19 (10). DOI: 10.3390/ijms19102933.
1.1.
2018
Ounpuu, Lyudmila; Truu, Laura; Shevchuk, Igor; Chekulayev, Vladimir; Klepinin, Aleksandr; Koit, Andre; Tepp, Kersti; Puurand, Marju; Rebane-Klemm, Egle; Käämbre, Tuuli (2018). Comparative analysis of the bioenergetics of human adenocarcinoma Caco-2 cell line and postoperative tissue samples from colorectal cancer patients. Biochemistry and Cell Biology. DOI: 10.1139/bcb-2018-0076.
1.1.
2018
Klepinin, Aleksandr; Ounpuu, Lyudmila; Mado, Kati; Truu, Laura; Chekulayev, Vladimir; Puurand, Marju; Shevchuk, Igor; Tepp, Kersti; Planken, Anu; Kaambre, Tuuli (2018). The complexity of mitochondrial outer membrane permeability and VDAC regulation by associated proteins. Journal of Bioenergetics and Biomembranes. DOI: 10.1007/s10863-018-9765-9.
5.1.
2018
Tepp, Kersti; Puurand, Marju; Klepinin, Aleksandr; Reile, Indrek; Kaambre, Tuuli; (2018). Alterations in energy transfer pathways in Wfs1 deficient mice. Biochimica et Biophysica Acta (BBA) - Bioenergetics, Volume 1859, Supplement, September 2018,, 1859: 20th European Bioenergetics Conference, August 25-30, 2018. Budapest, Hungary: European Bioenergetics Conference, e92.
5.2.
2018
Tepp, Kersti; Puurand, Marju; Klepinin, Aleksandr; Kaambre, Tuuli; (2018). Energy transfer in development and pathology – valuable information from oxygraphic measurements. Emerging Concepts in Mitochondrial Biology. Rehovot, Israel: Weizmann Institute of Science, 136.
1.1.
2017
Ounpuu, Lyudmila; Klepinin, Aleksandr; Pook, Martin; Teino, Indrek; Peet, Nadezda; Paju, Kalju; Tepp, Kersti; Chekulayev, Vladimir; Shevchuk, Igor; Koks, Sulev; Maimets, Toivo; Kaambre, Tuuli (2017). 2102Ep embryonal carcinoma cells have compromised respiration and shifted bioenergetic profile distinct from H9 human embryonic stem cells. Biochimica et Biophysica Acta (BBA) - General Subjects, 1861, 2146−2154. DOI: 10.1016/j.bbagen.2017.05.020.
1.1.
2017
Koit, Andre; Shevchuk, Igor; Ounpuu, Lyudmila; Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Tepp, Kersti; Puurand, Marju; Truu, Laura; Heck, Karoliina; Valvere, Vahur; Guzun, Rita; Kaambre, Tuuli (2017). Mitochondrial Respiration in Human Colorectal and Breast Cancer Clinical Material Is Regulated Differently. Oxidative Medicine and Cellular Longevity, 2017 (1372640), 1−16. DOI: 10.1155/2017/1372640.
1.1.
2017
Tepp, K.; Puurand, M.; Timohhina, N.; Adamson, J.; Klepinin, A.; Truu, L.; Shevchuk, I.; Chekulayev, V.; Kaambre, T. (2017). Changes in the mitochondrial function and in the efficiency of energy transfer pathways during cardiomyocyte aging. Molecular and Cellular Biochemistry, 432 (1-2), 141−158. DOI: 10.1007/s11010-017-3005-1.
5.2.
2017
Puurand, Marju; Tepp, K.; Klepinin, A.; Kaambre, T. (2017). Cellular phosphotransfer networks as a target of bioenergetic research – methods of oxygraphic study. 12th Conference on Mitochondrial Physiology. The role of mitochondria in lifestyle and metabolic syndrome - COST MitoEAGLE perspectives: Hradec Králové, Czech Republic;15-18 November 2017. Hradec Králové, Czech Republic: 12th Conference on Mitochondrial Physiology, 64−65.
1.1.
2016
Tepp, K.; Timohhina, N.; Puurand, M.; Klepinin,A.; Chekulayev, V.; Shevchuk,I.; Kaambre, T. (2016). Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies. Ageing Research Reviews, 28, 1−14. DOI: 10.1016/j.arr.2016.04.001.
5.1.
2016
Kersti Tepp; Marju Puurand; Natalja Timohhina; Jasper Adamson; Aleksandr Klepinin; Igor Shevchuk; Vladimir Chekulayev; Tuuli Käämbre (2016). New aspects of the bioenergetics of the aging heart — Changes in Intracellular Energetic Unit. In: Paolo Bernardi (Ed.). Biochimica et Biophysica Acta (BBA) - Bioenergetics (e100). EBEC 2016: 19th European Bioenergetics Conference, 02-07 July 2016 Riva del Garda, Italy. Elsevier. (Supplement). DOI: 10.1016/j.bbabio.2016.04.338.
1.1.
2015
Guzun, Rita; Kaambre, Tuuli; Bagur, Rafaela; Grichine, Alexei; Usson, Yves; Varikmaa, Minna; Anmann, Tiia; Tepp, Kersti; Timohhina, Natalja; Shevchuk, Igor; Chekulayev, Vladimir; Boucher, Francois; Dos Santos, Pierre; Schlattner, Uwe; Wallimann, Theo; Kuznetsov, Andrey; Dzeja, Petras; Aliev, Mayis; Saks, Valdur (2015). Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation. Acta Physiologica, 213 (1), 84−106. DOI: 10.1111/apha.12287.
1.1.
2015
Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Koit, Andre; Kaldma, Andrus; Klepinin, Aleksandr; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Ounpuu, Lyudmila; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Kaambre, Tuuli (2015). Metabolic remodeling in human colorectal cancer and surrounding tissues: alterations in regulation of mitochondrial respiration and metabolic fluxes. Biochemistry and Biophysics Reports, 4, 111−125.
5.2.
2015
Tepp, K.; Klepinin, A.; Timohhina, N.; Chekulayev, V.; Shevchuk, I.; Kaambre, T. (2015). Changes in energy transfer regulation during development and aging. 11th MiPconference on Mitochondrial Physiology. Lucni­ Bouda, Pec pod Snezkou, Czech Republic: MiPsociety, 76−77.
1.1.
2014
Kaldma, Andrus; Klepinin, Aleksandr; Chekulayev, Vladimir; Mado, Kati; Shevchuk, Igor; Timohhina, Natalja; Tepp, Kersti; Kandashvili, Manana; Varikmaa, Minna; Koit, Andre; Planken, Margus; Heck, Karoliina; Truu, Laura; Planken, Anu; Valvere, Vahur; Rebane, Egle; Kaambre, Tuuli. (2014). An in situ study of bioenergetic properties of human colorectal cancer: The regulation of mitochondrial respiration and distribution of flux control among the components of ATP synthasome. The International Journal of Biochemistry & Cell Biology, 55, 171−186. DOI: 10.1016/j.biocel.2014.09.004.
1.1.
2014
Klepinin, Aleksandr; Chekulayev, Vladimir; Timohhina, Natalja; Shevchuk, Igor; Tepp, Kersti; Kaldma, Andrus; Koit, Andre; Saks, Valdur; Kaambre, Tuuli (2014). Comparative analysis of some aspects of mitochondrial metabolism in differentiated and undifferentiated neuroblastoma cells. Journal of Bioenergetics and Biomembranes, 46 (1), 17−31. DOI: 10.1007/s10863-013-9529-5.
1.1.
2014
Anmann, Tiia; Varikmaa, Minna; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor, Chekulayev, Vladimir'; Saks, Valdur; Kaambre, Tuuli. (2014). Formation of highly organized intracellular structure and energy metabolism in cardiac muscle cells during postnatal development of rat heart. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1837 (8), 1350−1361. DOI: 10.1016/j.bbabio.2014.03.015.
1.1.
2014
Varikmaa, Minna; Bagur, Rafaela; Käämbre, Tuuli; Grichine, Alexei; Timohhina, Natalja; Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Metsis, Madis; Boucher, Francois; Saks, Valdur; Kuznetsov, Andrey V.; Guzun, Rita (2014). Role of mitochondria-cytoskeleton interactions in respiration regulation and mitochondrial organization in striated muscles. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1837 (2), 232−245. DOI: 10.1016/j.bbabio.2013.10.011.
1.1.
2014
Tepp, K.; Mado, K.; Varikmaa, M.; Klepinin, A.; Timohhina, N.; Shevchuk, I.; Chekulayev, V.; Kuznetsov, A. V.; Guzun, R.; Kaambre, T. (2014). The role of tubulin in the mitochondrial metabolism and arrangement in muscle cells. Journal of Bioenergetics and Biomembranes, 46, 421−434.
5.1.
2014
Timohhina, N; Tepp, K; Klepinin, A; Mado, K; Chekulayev, V; Shevchuk, I; Kaambre, T. (2014). Age-related changes in the cardiac cell functioning. Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1837: 18th European Bioenergetics Conference, Lisbon, Portugal, 12-17 July 2014. Elsevier, e65.
1.1.
2013
Kaambre, Tuuli; Chekulayev, Vladimir; Shevchuk, Igor; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Bagur, Rafaela; Klepinin, Aleksandr; Anmann, Tiia; Koit, Andre; Kaldma, Andrus; Guzun, Rita; Valvere, Vahur; Saks, Valdur (2013). Metabolic Control Analysis of Respiration in Human Cancer Tissue. Frontiers in Physiology, 4, 1−6. DOI: 10.3389/fphys.2013.00151.
1.3.
2013
Anmann, Tiia; Varikmaa, Minna; Tepp, Kersti; Timohhina, Natalja; Ševtšuk, Igor; Tšekulajev, Vladimir; Saks, Valdur; Käämbre, Tuuli (2013). Südamerakkude sünnijärgse arengu bioenergeetilised aspektid: struktuuri ja funktsiooni vaheliste seoste väljakujunemine [Bioenergetic aspects of postnatal development of cardiac cells: formation of structure-function relationship]. Eesti Arst, 92 (7), 372−381.
1.1.
2012
Käämbre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Tepp, K.; Bogovskaja, J.; Kütner, R.; Valvere, V.; Saks, V. (2012). Metabolic control analysis of cellular respiration in situ in intraoperational samples of human breast cancer. Journal of Bioenergetics and Biomembranes, 44 (5), 539−558. DOI: 10.1007/s10863-012-9457-9.
1.1.
2012
Gonzalez-Granillo, M.; Grichine, A.; Guzun, R.; Ussov, Y.; Tepp, K.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Kuznetsov, A.V.; Grimm, M.; Saks, V.; Käämbre, T. (2012). Studies of the role of tubulin beta II isotype in regulation of mitochondrial respiration in intracellular energetic units in cardiac cells. Journal of Molecular and Cellular Cardiology, 52, 437−447. DOI: 10.1016/j.yjmcc.2011.07.027.
1.1.
2012
Saks, V.; Kuznetsov, A.V.; Gonzalez-Granillo, M.; Tepp, K.; Timohhina, N.; Karu-Varikmaa, M.; Käämbre, T.; Santos, P.D.; Boucher, F.; Guzun, R. (2012). Intracellular energetic Units regulate metabolism in cardiac cells. Journal of Molecular and Cellular Cardiology, 419−436. DOI: 10.1016/j.yjmcc.2011.07.015.
5.1.
2012
Tepp, K.; Kaambre, T.; Chekulayev, V.; Shevchuk, I.; Karu-Varikmaa, M.; Timohhina, N.; Valvere, V.; Saks, V. (2012). Comparative investigation of bioenergetic properties of human colorectal and breast cancer. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1817: 17th European Bioenergetics Conference (EBEC), Freiburg, 15. - 20. September 2012. Elsevier, S135−S136. (supplement to volume 1817).
1.1.
2011
Tepp, Kersti; Shevchuk, Igor; Chekulayev, Vladimir; Timohhina, Natalja; Kuznetsov, Andrey V.; Guzun, Rita; Saks, Valdur; Käämbre, Tuuli (2011). High efficiency of energy flux controls within mitochondrial interactosome in cardiac intracellular energetic units. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1807 (12), 1549−1561. DOI: 10.1016/j.bbabio.2011.08.005.
1.1.
2011
Guzun, R.; Timohhina, N.; Tepp, K.; Gonzalez-Granillo, M.; Shevchuk, I.; Chekulayev, V.; Kuznetsov, A.V.; Käämbre, T.; Saks, V.A. (2011). Systems bioenergetics of creatine kinase networks: physiological roles of creatine and phosphocreatine in regulation of cardiac cell function. Amino Acids, 40, 1333−1348.
1.1.
2011
Martma, K.; Habicht, K.-L.; Martinez Ramirez, X.; Tepp, K.; Käämbre, T.; Volobujeva, O.; Shimmo, R. (2011). Polydopamine as an adhesive coating for open tubular capillary electrochromatography. Electrophoresis, 32 (9), 1054−1060. DOI: 10.1002/elps.201000569.
5.1.
2011
Tepp, K.; Shevchuk, I.; Chekulayev, V.; Timohhina, N.; Saks, V.; Käämbre, T. (2011). High efficiency of energy flux control with mitochondrial interactosome in cardiac cell. FEBS Journal, 278, 377−377.
1.1.
2010
Tepp, Kersti; Timohhina, Natalya; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes - experimental study. Acta Biochimica Polonica, 57 (4), 421−430.
1.1.
2010
Saks, Valdur; Guzun, Rita; Timohhina, Natalja; Tepp, Kersti; Varikmaa, Minna; Monge, Claire; Beraud, Nathalie; Käämbre, Tuuli; Kuznetsov, Andrey; Kadaja, Lumme; Eimre, Margus; Seppet, Enn (2010). Structure-function relationships in feedback regulation of energy fluxes in vivo in health and disease: Mitochondrial Interactosome. Biochimica et Biophysica Acta, 1797 (6-7), 678−697. DOI: 10.1016/j.bbabio.2010.01.011.
3.1.
2010
Monge, Claire; Guzun, Rita; Tepp, Kersti; Timohhina, Natalja; Varikmaa, Minna; Sikk, Peeter; Käämbre, Tuuli; Saks, Valdur (2010). Mitochondrial Interactosome in Health and Disease: Structural and Functional Aspects of Molecular System Bioenergetics of Muscle and Neuronal Cells. In: Oliver L. Svensson (Ed.). Mitochondria: Structure, Functions and Dysfunctions (441−470). . Nova Science Publisher Inc..
5.1.
2010
Tepp, Kersti; Timohhina, Natalja; Chekulayev, Vladimir; Shevchuk, Igor; Kaambre, Tuuli; Saks, Valdur (2010). Metabolic control analysis of integrated energy metabolism in permeabilized cardiomyocytes. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1797: 16th European Bioenergetics Conference - Warsaw, 17-22 July 2010. Ed. L. Wojtczak and K. Zabłocki. Elsevier Sci, 138−139. (Supplement 1). DOI: 10.1016/j.bbabio.2010.04.413.
1.1.
2009
Timohhina, Natalja; Guzun, Rita; Tepp, Kersti; Monge, Claire; Varikmaa, Minna; Vija, Heiki; Sikk, Peeter; Käämbre, Tuuli; Sackett, Dan; Saks, Valdur (2009). Direct measurement of energy fluxes from mitochondria into cytoplasm in permeabilized cardiac cells in situ: some evidence for mitochondrial interactosome. Journal of Bioenergetics and Biomembranes, 41 (3), 259−275.
1.1.
2009
Guzun, R.; Timohhina, N.; Tepp, K.; Monge, C.; Käämbre, T.; Sikk, P.; Kuznetsov, AV.; Pison, C.; Saks, V. (2009). Regulation of respiration controlled by mitochondrial creatine kinase in permeabilized cardiac cells in situ importance of system level properties. Biochimica et Biophysica Acta (BBA) - Bioenergetics, 1787 (9), 1089−1105. DOI: 10.1016/j.bbabio.2009.03.024.
1.1.
2009
Monge, Claire; Beraud, Nathalie; Tepp, Kersti; Pelloux, Sophie; Chahboun, Siham; Käämbre, Tuuli; Kadaja, Lumme; Roosimaa, Mart; Piirsoo, Andres; Tourneur, Yves; Kuznetsov, Andrey V; Saks, Valdur; Seppet, Enn (2009). Comparative analysis of the bioenergetics of adult cardiomyocytes and nonbeating HL-1 cells: respiratory chain activities, glycolytic enzyme profiles, and metabolic fluxes. Canadian Journal of Physiology and Pharmacology, 87 (4), 318−326.
1.1.
2009
Sikk, Peeter; Käämbre, Tuuli; Vija, Heiki; Tepp, Kersti; Tiivel, Toomas; Nutt, Anu; Saks, Valdur (2009). Ultra performance liquid chromatography analysis of adenine nucleotides and creatine derivatives for kinetic studies. Proceedings of the Estonian Academy of Sciences, 58 (2), 122−131.
1.3.
2008
Käämbre, Tuuli; Sikk, Peeter; Anmann, Tiia; Tiivel, Toomas; Timohhina, Natalja; Nutt, Anu; Tepp, Kersti; Saks, Valdur (2008). Südamelihase rakkude struktuuri olulisusest rakuhingamise regulatsioonis. Eesti Arst, 1, 19−22.
21.03.2022

Otsi projekti

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Uus Frascati (2015)
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  • Leitud 7 kirjet
ProgrammLiikNumberNimiProjekti algusProjekti lõppVastutav täitjaAsutusFinantseerijapoolne rahastamine
ETFETF7117Energeetilise metabolismi kompartmentaliseeritud süsteemid ja nende häired südame-, maoepiteeli- ja ajurakkudes01.01.200731.12.2010Enn SeppetTartu Ülikool, Arstiteaduskond75 160,08 EUR
IUTIUT23-1Integreeritud energeetilise metabolismi regulatsioonimehhanismid kasvaja- ning lihasrakkudes. 01.01.201431.12.2019Tuuli KäämbreKeemilise ja Bioloogilise Füüsika Instituut1 013 400,00 EUR
SFSF0180114Bs08Integreeritud energeetilise metabolismi regulatsioonimehhanismid lihasrakkudes01.01.200831.12.2013Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut657 119,57 EUR
ETFETF6142Kompartmentaliseeritud energia transpordi võrgud kardiomüotsüütides ja eelkohastumise mehhanismid01.01.200531.12.2008Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut91 581,62 EUR
ETFETF7823Raku energiaühikute moodustumise dünaamika tüvirakkude differentseerumise protsessis lihasrakkudeks ja nende degradatsioon vananemise käigus01.01.200931.12.2012Valdur SaksKeemilise ja Bioloogilise Füüsika Instituut88 352,54 EUR
PRGPRG1035Rinna- ja soolevähi onkobioenergeetika in vitro mudelites ja kliinilisel materjalil: “oomikteadusest” matemaatilise modelleerimiseni01.01.202131.12.2021Tuuli KäämbreKeemilise ja Bioloogilise Füüsika Instituut257 125,00 EUR
ETFETF8987Vähirakkude bioenergeetilise profiili määramine diagnostikas ja ravis. 01.01.201231.12.2015Tuuli KäämbreKeemilise ja Bioloogilise Füüsika Instituut69 600,00 EUR